Phosphatase Gene PTPN1

Phosphatase Classification: Fold CC1: Superfamily CC1: Family PTP: Subfamily PTPN1: Gene PTPN1

Evolution

See evolution section on page of Subfamily PTPN1.

Functions

PTPN1 is perhaps the best understood classical PTP. It is a critical negative regulator of insulin and leptin signaling, as well as other receptor tyrosine kinases and cytokine receptors, and is known to undergo reversible oxidation (see review [1]). Recently, it has been reported that inactivation of PTP1B by reactive oxygen species is essential for oncogene-induced senescence (OIS), which prevents the progression of preneoplastic cells harboring oncogenic mutations [2].