Phosphatase Subfamily MTMR6

Phosphatase Classification: FoldCC1: Superfamily CC1: Family Myotubularin: Subfamily MTMR6

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Evolution

MTMR6 subfamily is found throughout holozoan. Human and most if not all vertebrates has three members per genome: MTMR6, MTMR7 and MTMR8. Other metazoan such as fruit fly and C elegans has a single member.

Domain Structure

MTMR6 subfamily has three domains: PH/GRAM, phosphatase domain and coiled-coil domain. The GRAM domain is similar to PH domain in structure and is found in membrane-associated proteins. As shown in MTMR3 subfamily, PH/GRAM domain can bind to phosphoinositide lipids. Coiled-coil domain has been shown to mediate the interaction with MTMR9 in human [1, 2, 3].

Catalytic activity and functions

The enzymatic activity of all three human MTMR6s are up-regulated by pseudophosphatase MTMR9 through protein interactions[1, 2, 3]. The interaction between MTMR9 and MTMR6 subfamily is also observed in C elegans [4].

References

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