Phosphatase Subfamily PTPRB

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Phosphatase Classification: Fold CC1: Superfamily CC1: Family PTP: Subfamily PTPRB


PTPRC (CD45) is a vertebrate-specific receptor PTP involved in immune signaling.

Evolution

PTPRB subfamily is found across metazoan. It has multiple copies per genomes in bilateral.

Domain Structure

Functions

CD45 modulates immune function [1]. It is selectively expressed on lymphocytes and dephosphorylates and activates the src family tyrosine kinases lck, fyn and lyn in B and T cells.

References

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  1. Error fetching PMID 25128530: [furlan14]
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