Phosphatase Subfamily CUT

Phosphatase Classification: Fold HAD: Superfamily HAD: Family NagD: Subfamily CUT

Cut genes are related to other eukaryotic NagD phosphatases, but have not been shown to have protein phosphatase activity.

Evolution

This family is present throughout eukaryotes, mostly single-copy but with several duplications. It is lost from Drosophila but present in other arthropods.

Domain

CUT has a single domain, HAD domain.

Function

Cut proteins are localized to the mitochondria [1, 2]. CECR5, the human Cut gene, has been shown to associate with ICT1, a mitochondrial peptidyl-tRNA hydrolase [3] and yeast Cut (YKR070W) genetically interacts with PTH1, a related aminoacyl tRNA hydrolase. A Neurospora homolog, cut-1 is expressed in a light-dependent manner and required for response to osmotic stress [4]. An PhD thesis reports that YKR070W shows phosphatase activity against sugar and glycerol phosphates (https://tspace.library.utoronto.ca/bitstream/1807/19048/1/Kuznetsova_Ekaterina_200911_PhD_thesis.pdf, p129).

References

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