Phosphatase Superfamily CC2

Phosphatase Classification: Fold CC2: Superfamily CC2

This superfamily has a unique fold, but shares the common CX5R catalytic motif with another two cysteine-based superfamilies, CC1 and CC3.

CC2 consists of two member families in human low molecular weight PTP (LWMPTP) and SSU72. Despite having only 15% sequence identity, human LMWPTP and SSU72 structures superimpose with an rmsd of 1.7 Å [1].

A third family, arsenate reductase (ArsC) [2], is only found in prokaryotes. While known to reduce arsenate to arsenite (a similar reaction to the phosphatase reaction), the B. subtilis gene also has in vitro phosphatase activity. A different phosphatase fold, CDC25/Rhodanese also has members in plants and yeast (ACR2) that are capable of arsenate reductase activity, highlighting the similarity of the protein phosphatase and arsenate reductase activities.

Phosphatase domain structure

The two families LWMPTP and SSU72 has a common fold.

The SSU72 family has a secondary structure combination of E1, H1, E2, E3, E4, H2, H3, H4, E5, H5, E6, H6, H7, E7.

The LWMPTP family has a secondary structure combination of E1, H1, E2, H4 (or H3), E5, H5, E6, H6.

References

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