Difference between revisions of "Phosphatase Family NagD"

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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_HAD|Fold HAD]]: [[Phosphatase_Superfamily_HAD|Superfamily HAD]]: [[Phosphatase_Family_NagD|Family NagD]]
 
[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_HAD|Fold HAD]]: [[Phosphatase_Superfamily_HAD|Superfamily HAD]]: [[Phosphatase_Family_NagD|Family NagD]]
  
The NagD family of HAD-fold phosphatases has three eukaryotic subfamilies containing protein phosphatases:
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The NagD family of HAD-fold phosphatases has three eukaryotic subfamilies:
  
* [[Phosphatase_Subfamily_PGP|PGP]]
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* [[Phosphatase_Subfamily_PGP|PGP]] is ubiquitous in eukaryotes. The two members in human have distinct functions: PGP is a putative tyrosine-specific protein phosphatase, and PDXP (chronophin) dephosphorylates cofilin on serine, and also dephosphorylates pyridoxal 5'-phosphate. PDXP is mainly expressed in brain; PGP is widely expressed in different tissues.
  
* [[Phosphatase_Subfamily_LHPP|LHPP]] is a protein histidine phosphatase subfamily conserved in holozoan.
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* [[Phosphatase_Subfamily_LHPP|LHPP]] is a protein histidine phosphatase subfamily conserved in holozoa.
  
* [[Phosphatase_Subfamily_CUT|CUT]] - no strong evidence supports it has protein phosphatase activity.
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* [[Phosphatase_Subfamily_CUT|CUT]] is a mitochondrial-associated probable non-protein phosphatase.

Latest revision as of 20:15, 21 March 2015

Phosphatase Classification: Fold HAD: Superfamily HAD: Family NagD

The NagD family of HAD-fold phosphatases has three eukaryotic subfamilies:

  • PGP is ubiquitous in eukaryotes. The two members in human have distinct functions: PGP is a putative tyrosine-specific protein phosphatase, and PDXP (chronophin) dephosphorylates cofilin on serine, and also dephosphorylates pyridoxal 5'-phosphate. PDXP is mainly expressed in brain; PGP is widely expressed in different tissues.
  • LHPP is a protein histidine phosphatase subfamily conserved in holozoa.
  • CUT is a mitochondrial-associated probable non-protein phosphatase.