Difference between revisions of "Phosphatase Subfamily DSP19"
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| + | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_DSP|Family DSP]]: [[Phosphatase_Subfamily_DSP19|Subfamily DSP19]] | ||
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| + | DSP19 is a phosphatase subfamily widely found in eukaryotes but absent from fungi. It functions in the regulation of JNK signaling but the precise molecular mechanism is unclear. | ||
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| + | === Evolution === | ||
| + | DSP19 subfamily is found in most eukaryotes except fungi ([http://resdev.gene.com/gOrtholog/view/cluster/MC0004288/overview unpublished data from gOrtholog]). | ||
| + | |||
| + | === Domain === | ||
| + | DSP19 has a single domain: phosphatase domain. | ||
| + | |||
| + | === Function === | ||
| + | Human DUSP19 (SKRP1) appears to play a specific role in the regulation of jun-kinase (JNK) signaling; however, the precise mechanism is unclear. | ||
| + | DUSP19 interacts physically with the MAPK kinase (MAPKK) MKK7, a c-Jun N-terminal kinase (JNK) activator, and inactivates the MAPK JNK pathway <cite>Zama02a</cite>. DUSP19 also interacted with the MAPKKK, apoptosis signal-regulating kinase 1 (ASK1), but not with MAP kinase kinase kinase 1 (MEKK1) <cite>Zama02b</cite> | ||
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| + | |||
| + | === References === | ||
| + | <biblio> | ||
| + | #Zama02a pmid= 11959861 | ||
| + | #Zama02b pmid= 11959862 | ||
| + | </biblio> | ||
Revision as of 03:38, 3 March 2015
Phosphatase Classification: Fold CC1: Superfamily CC1: Family DSP: Subfamily DSP19
DSP19 is a phosphatase subfamily widely found in eukaryotes but absent from fungi. It functions in the regulation of JNK signaling but the precise molecular mechanism is unclear.
Evolution
DSP19 subfamily is found in most eukaryotes except fungi (unpublished data from gOrtholog).
Domain
DSP19 has a single domain: phosphatase domain.
Function
Human DUSP19 (SKRP1) appears to play a specific role in the regulation of jun-kinase (JNK) signaling; however, the precise mechanism is unclear. DUSP19 interacts physically with the MAPK kinase (MAPKK) MKK7, a c-Jun N-terminal kinase (JNK) activator, and inactivates the MAPK JNK pathway [1]. DUSP19 also interacted with the MAPKKK, apoptosis signal-regulating kinase 1 (ASK1), but not with MAP kinase kinase kinase 1 (MEKK1) [2]
References
- pmid= 11959861
- pmid= 11959862
