Difference between revisions of "Phosphatase Subfamily DSP23"
| Line 2: | Line 2: | ||
[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_DSP|Family DSP]]: [[Phosphatase_Subfamily_DSP23|Subfamily DSP23]] | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_DSP|Family DSP]]: [[Phosphatase_Subfamily_DSP23|Subfamily DSP23]] | ||
| − | DSP23 is a nuclear phosphatase found in metazoan but lost in | + | DSP23 is a nuclear phosphatase found in metazoan but lost in most ecdysozoa. |
=== Evolution === | === Evolution === | ||
| − | DSP23 is found in | + | DSP23 is found in metazoa but lost in nematodes and most arthropods ([http://resdev.gene.com/gOrtholog/view/cluster/MC0006453/overview unpublished data from gOrtholog]). It has a single human member, DUSP23. |
=== Domain === | === Domain === | ||
| Line 11: | Line 11: | ||
=== Function === | === Function === | ||
| − | Human DUSP23 dephosphorylates Ser322 on Glial cells missing homolog 1 | + | Human DUSP23 dephosphorylates Ser322 on GCM1 (Glial cells missing homolog 1), a transcription factor essential for placental development. The dephosphorylation promotes GCM1 acetylation <cite>Lin11</cite>. |
DSP23 is also called VHZ for its similarity with VHR phosphatase. Different from MAP kinases phosphatases which negatively regulate MAP kinases such as JNK and p38, DSP23 has been reported to enhance activation of JNK and p38 <cite>Takagaki04</cite>. Human DSP23 locates at centrosome in [http://en.wikipedia.org/wiki/MCF-7 MCF-7] cells and is proposed to be involved in cell growth and human primary cancers. <cite>Tang10</cite>. | DSP23 is also called VHZ for its similarity with VHR phosphatase. Different from MAP kinases phosphatases which negatively regulate MAP kinases such as JNK and p38, DSP23 has been reported to enhance activation of JNK and p38 <cite>Takagaki04</cite>. Human DSP23 locates at centrosome in [http://en.wikipedia.org/wiki/MCF-7 MCF-7] cells and is proposed to be involved in cell growth and human primary cancers. <cite>Tang10</cite>. | ||
Revision as of 05:30, 22 March 2017
Phosphatase Classification: Fold CC1: Superfamily CC1: Family DSP: Subfamily DSP23
DSP23 is a nuclear phosphatase found in metazoan but lost in most ecdysozoa.
Evolution
DSP23 is found in metazoa but lost in nematodes and most arthropods (unpublished data from gOrtholog). It has a single human member, DUSP23.
Domain
DSP23 has a single domain, the phosphatase domain. Actually, it is the shortest within DSP family [1].
Function
Human DUSP23 dephosphorylates Ser322 on GCM1 (Glial cells missing homolog 1), a transcription factor essential for placental development. The dephosphorylation promotes GCM1 acetylation [2].
DSP23 is also called VHZ for its similarity with VHR phosphatase. Different from MAP kinases phosphatases which negatively regulate MAP kinases such as JNK and p38, DSP23 has been reported to enhance activation of JNK and p38 [3]. Human DSP23 locates at centrosome in MCF-7 cells and is proposed to be involved in cell growth and human primary cancers. [4].
References
Error fetching PMID 20855292:
Error fetching PMID 15281913:
Error fetching PMID 20509867:
- Error fetching PMID 15201283:
- Error fetching PMID 20855292:
- Error fetching PMID 15281913:
- Error fetching PMID 20509867:
