Difference between revisions of "Phosphatase Subfamily PTPN1"
From PhosphataseWiki
| Line 1: | Line 1: | ||
| − | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[ | + | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_CC1|Fold CC1]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_PTPN1|Subfamily PTPN1]] |
Two copies in human, [[Phosphatase_Gene_PTPN1|PTPN1 (PTP1B)]] and [[Phosphatase_Gene_PTPN2|PTPN2]]. It contains a single phosphatase domain. They dephoshorylate kinases of various families, including Insulin receptor kinase (InsR), epidermal growth factor receptor kinase (EGFR), JAK (JAK2 and TYK2). The phosphatase emerged later than the related kinases. The phosphatase first emerged in Trichoplax. EGFR is conserved from sponge to human but lost in Trichoplax, and InsR is conserved from Trichoplax to human. | Two copies in human, [[Phosphatase_Gene_PTPN1|PTPN1 (PTP1B)]] and [[Phosphatase_Gene_PTPN2|PTPN2]]. It contains a single phosphatase domain. They dephoshorylate kinases of various families, including Insulin receptor kinase (InsR), epidermal growth factor receptor kinase (EGFR), JAK (JAK2 and TYK2). The phosphatase emerged later than the related kinases. The phosphatase first emerged in Trichoplax. EGFR is conserved from sponge to human but lost in Trichoplax, and InsR is conserved from Trichoplax to human. | ||
| + | |||
| + | (PS: Why PTPN1 and PTPN2 have different functions?) | ||
Revision as of 20:48, 17 December 2014
Phosphatase Classification: Fold CC1: Superfamily CC1: Family PTP: Subfamily PTPN1
Two copies in human, PTPN1 (PTP1B) and PTPN2. It contains a single phosphatase domain. They dephoshorylate kinases of various families, including Insulin receptor kinase (InsR), epidermal growth factor receptor kinase (EGFR), JAK (JAK2 and TYK2). The phosphatase emerged later than the related kinases. The phosphatase first emerged in Trichoplax. EGFR is conserved from sponge to human but lost in Trichoplax, and InsR is conserved from Trichoplax to human.
(PS: Why PTPN1 and PTPN2 have different functions?)
