Difference between revisions of "Phosphatase Subfamily PTPRB"
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===Evolution=== | ===Evolution=== | ||
| − | + | PTPRB subfamily is found across metazoan. It has multiple copies per genomes in bilateral. | |
===Domain Structure=== | ===Domain Structure=== | ||
Revision as of 00:41, 25 February 2015
Phosphatase Classification: Fold CC1: Superfamily CC1: Family PTP: Subfamily PTPRB
PTPRC (CD45) is a vertebrate-specific receptor PTP involved in immune signaling.
Evolution
PTPRB subfamily is found across metazoan. It has multiple copies per genomes in bilateral.
Domain Structure
PTPRC has twin intracellular PTP phosphatase domains, and extracellular FN3 domains, plus a CD45-specific and a PTP-N-terminal domain found specifically in PTPRC, as annotated by InterPro. CD45 is extensively alternatively spliced.
Functions
CD45 modulates immune function [1]. It is selectively expressed on lymphocytes and dephosphorylates and activates the src family tyrosine kinases lck, fyn and lyn in B and T cells.
