Difference between revisions of "Phosphatase Subfamily PTPRB"

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===Domain Structure===
 
===Domain Structure===
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PTPRC has twin intracellular PTP phosphatase domains, and extracellular FN3 domains, plus a CD45-specific and a PTP-N-terminal domain found specifically in PTPRC, as annotated by InterPro. CD45 is extensively alternatively spliced.
 
  
 
===Functions===
 
===Functions===

Revision as of 00:41, 25 February 2015


Phosphatase Classification: Fold CC1: Superfamily CC1: Family PTP: Subfamily PTPRB


PTPRC (CD45) is a vertebrate-specific receptor PTP involved in immune signaling.

Evolution

PTPRB subfamily is found across metazoan. It has multiple copies per genomes in bilateral.

Domain Structure

Functions

CD45 modulates immune function [1]. It is selectively expressed on lymphocytes and dephosphorylates and activates the src family tyrosine kinases lck, fyn and lyn in B and T cells.

References

  1. Furlan G, Minowa T, Hanagata N, Kataoka-Hamai C, and Kaizuka Y. Phosphatase CD45 both positively and negatively regulates T cell receptor phosphorylation in reconstituted membrane protein clusters. J Biol Chem. 2014 Oct 10;289(41):28514-25. DOI:10.1074/jbc.M114.574319 | PubMed ID:25128530 | HubMed [furlan14]
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