Difference between revisions of "Phosphatase Subfamily PTPRB"

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(Domain Structure)
(Functions)
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===Functions===
 
===Functions===
CD45 modulates immune function <cite>furlan14</cite>. It is selectively expressed on lymphocytes and dephosphorylates and activates the [http://kinase.com/wiki/index.php/Kinase_Family_Src src family] tyrosine kinases lck, fyn and lyn in B and T cells.
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(summary)
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===== PTPRB (VE-PTP) =====
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PTPRB is glycosylated (phosphacan).
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PTPRB interacts with neuronal receptors and promotes neurite outgrowth <cite>Garwood03</cite>.
  
 
===References===
 
===References===

Revision as of 00:58, 25 February 2015


Phosphatase Classification: Fold CC1: Superfamily CC1: Family PTP: Subfamily PTPRB


PTPRC (CD45) is a vertebrate-specific receptor PTP involved in immune signaling.

Evolution

PTPRB subfamily is found across metazoan. It has multiple copies per genomes in bilateral.

Domain Structure

Functions

(summary)

PTPRB (VE-PTP)

PTPRB is glycosylated (phosphacan).

PTPRB interacts with neuronal receptors and promotes neurite outgrowth [1].

References

  1. Furlan G, Minowa T, Hanagata N, Kataoka-Hamai C, and Kaizuka Y. Phosphatase CD45 both positively and negatively regulates T cell receptor phosphorylation in reconstituted membrane protein clusters. J Biol Chem. 2014 Oct 10;289(41):28514-25. DOI:10.1074/jbc.M114.574319 | PubMed ID:25128530 | HubMed [furlan14]