Difference between revisions of "Phosphatase Subfamily PTPRB"
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Revision as of 00:59, 25 February 2015
Phosphatase Classification: Fold CC1: Superfamily CC1: Family PTP: Subfamily PTPRB
PTPRC (CD45) is a vertebrate-specific receptor PTP involved in immune signaling.
Evolution
PTPRB subfamily is found across metazoan. It has multiple copies per genomes in bilateral.
Domain Structure
Functions
(summary)
PTPRB (VE-PTP)
PTPRB is glycosylated (phosphacan).
PTPRB interacts with neuronal receptors and promotes neurite outgrowth [1].
References
- Garwood J, Heck N, Reichardt F, and Faissner A. Phosphacan short isoform, a novel non-proteoglycan variant of phosphacan/receptor protein tyrosine phosphatase-beta, interacts with neuronal receptors and promotes neurite outgrowth. J Biol Chem. 2003 Jun 27;278(26):24164-73. DOI:10.1074/jbc.M211721200 |
