Phosphatase Subfamily PTPRB
From PhosphataseWiki
Phosphatase Classification: Fold CC1: Superfamily CC1: Family PTP: Subfamily PTPRB
PTPRC (CD45) is a vertebrate-specific receptor PTP involved in immune signaling.
Evolution
PTPRB subfamily is found across metazoan. It has multiple copies per genomes in bilateral.
Domain Structure
Functions
CD45 modulates immune function [1]. It is selectively expressed on lymphocytes and dephosphorylates and activates the src family tyrosine kinases lck, fyn and lyn in B and T cells.