Difference between revisions of "Phosphatase Superfamily HAD"

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[[Phosphatase classification|Phosphatase Classification]]:  [[Phosphatase_Group_HAD|HAD]]
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__NOTOC__
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[[Phosphatase classification|Phosphatase Classification]]:  [[Phosphatase_Fold_HAD|Fold HAD]]: [[Phosphatase_Superfamily_HAD|Superfamily HAD]]
  
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=== Families ===
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The HAD (HaloAcid Dehalogenase) superfamily contains many different hydrolase enzymes, including three with reported protein phosphatase activity <cite>Koonin, Burroughs</cite>:
  
The HAD (HaloAcid Dehalogenase) superfamily contains an array of different hydrolase enzymes, including several that are known to have protein phosphatase or other phosphatase activites <cite>Koonin, Burroughs</cite>. The following HAD families have reported protein phosphatase activity:
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* '''[[Phosphatase_Family_EYA|EYA family]]'''
  
[[Phosphatase_Family_EYA|EYA]] (Eyes Absent)
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* '''[[Phosphatase_Family_FCP|FCP family]]'''
  
[[Phosphatase_Family_FCP|FCP]]
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* '''[[Phosphatase_Family_NagD|NagD family]]'''
  
[[Phosphatase_Family_NagD|NagD]]
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Note: The [[Phosphatase_Family_MDP1|MDP1 family]] has been removed from the protein phosphatome, because it has been confirmed as a protein-fructosamine-6-phosphatase.
  
[[Phosphatase_Family_MDP1|MDP1]]
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=== Unclassifed HADs ===
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* Yeast SER2 is a putative protein serine phosphatase <cite>Kuznetsova15</cite>. It does not belong to any family above.
  
== References ==
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=== References ===
 
<biblio>
 
<biblio>
 
#Burroughs pmid=16889794
 
#Burroughs pmid=16889794
 
#Koonin pmid=7966317
 
#Koonin pmid=7966317
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#Kuznetsova15 pmid=26071590
 
</biblio>
 
</biblio>

Latest revision as of 04:40, 9 May 2016

Phosphatase Classification: Fold HAD: Superfamily HAD

Families

The HAD (HaloAcid Dehalogenase) superfamily contains many different hydrolase enzymes, including three with reported protein phosphatase activity [1, 2]:

Note: The MDP1 family has been removed from the protein phosphatome, because it has been confirmed as a protein-fructosamine-6-phosphatase.

Unclassifed HADs

  • Yeast SER2 is a putative protein serine phosphatase [3]. It does not belong to any family above.

References

  1. Koonin EV and Tatusov RL. Computer analysis of bacterial haloacid dehalogenases defines a large superfamily of hydrolases with diverse specificity. Application of an iterative approach to database search. J Mol Biol. 1994 Nov 18;244(1):125-32. DOI:10.1006/jmbi.1994.1711 | PubMed ID:7966317 | HubMed [Koonin]
  2. Burroughs AM, Allen KN, Dunaway-Mariano D, and Aravind L. Evolutionary genomics of the HAD superfamily: understanding the structural adaptations and catalytic diversity in a superfamily of phosphoesterases and allied enzymes. J Mol Biol. 2006 Sep 1;361(5):1003-34. DOI:10.1016/j.jmb.2006.06.049 | PubMed ID:16889794 | HubMed [Burroughs]
  3. Kuznetsova E, Nocek B, Brown G, Makarova KS, Flick R, Wolf YI, Khusnutdinova A, Evdokimova E, Jin K, Tan K, Hanson AD, Hasnain G, Zallot R, de Crécy-Lagard V, Babu M, Savchenko A, Joachimiak A, Edwards AM, Koonin EV, and Yakunin AF. Functional Diversity of Haloacid Dehalogenase Superfamily Phosphatases from Saccharomyces cerevisiae: BIOCHEMICAL, STRUCTURAL, AND EVOLUTIONARY INSIGHTS. J Biol Chem. 2015 Jul 24;290(30):18678-98. DOI:10.1074/jbc.M115.657916 | PubMed ID:26071590 | HubMed [Kuznetsova15]
All Medline abstracts: PubMed | HubMed