Gene DSP1 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP1
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP004_AA protein Get Run
AqueP004_AA_184-329 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Rhodanese Rhodanese-like domain 29-148 4.4e-12 38.5 Pfam-A 3-112 (113) alignment 
Range on Protein: 29-148
Range on HMM: 3-112/113.0
SELAKKIeeDREQWLLLDTRSFSLYSGKHIDNARSFAFAPMlmkrlLKGTASLDSLILRLTDTSLLSSIGAAERIVLYDSNSTPSETKADLVKLVETLQA
.||....  . |...|||.||.. |.. || .|.....  .      . ... .   |     ..  ...   ..|.|..... |.. | |..  .  ..
kelkell..ekekvvllDvRspeeyakghIpgAvnvpldsl.....yprrdlffkdklaeeleesgkkldkdktvvvycrsgnrsggaaalllalilkel

RFEnklNIRVLLGGMETFQE
 ..   |..|| ||.| ...
gyk...nvyvLdGGfeawka
subfamily_DSP1_pd Subfamily DSP1 178-330 4.4e-65 212.7 In-house 13-161 (163) alignment 
Range on Protein: 178-330
Range on HMM: 13-161/163.0
TGYDtpegtPVE-ILPFLYLGSAKDSSDLRILKKMNITAVLNITTSCPNHFEPYLEYKSIPVEDTHQADLLSRLQTAINFIDEIKSKGGRVFVHCHAGIS
. ||     ||| ||.||||||....|.|.|||...|||.||......|.|| ..|||....||...||. . ....|.||||.|.|.|.|..||.||||
klyd.....PvekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGis

RSATVCIAYLMQHKKVTMTEAYKYVQSRRPIISPNLGFMGQLMVHQKNLELHWT
||.|.|.||||..|.|...||...|..||.|||||.||..||. ..|.|.|...
RsstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekklllele
0045098 (Phosphotyrosine protein) phosphatases II 178-324 3.5e-34 113.9 In-house 13-270 (278) alignment 
Range on Protein: 178-324
Range on HMM: 13-270/278.0
TGYDTPEGTPVEILPFLYLGSAK-----------------------------------------DSSDLRILKKMNITAVLNIT----------------
. .  . | | ||.|.||||...                                          ....| |....||.....|                
fefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe

------------------------------------TSCPNHFEPYLEYKSIPVEDTHQADLLSRLQTAINFIDEIKS--------------KGGRVFVH
                                    .......  .| |...|  ...  ..|. .. ...||.|  .              .||.|.||
ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVH

CHAGISRSATVCIAYLMQHK---KVTMTEAYKYVQSRRPI-ISPNLGFMGQLMVHQKN
|.||..|..|...|||| .    .|.. ||.|...|.||. . .||... .|.  .  
CsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyeflle
0037934 (Phosphotyrosine protein) phosphatases II 178-321 9.2e-31 102.7 In-house 30-237 (243) alignment 
Range on Protein: 178-321
Range on HMM: 30-237/243.0
TGYDTPEGTPVEILPFLYLGSA--------KDSSDLRILKKMNITAVLNITTSC---------------------------------------------P
 | |   .  ....| |.....        .. |..| |.. .||.....|. .                                             .
egsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldld

NHFEPYLEYKSIPVED----THQADLLSRLQTAINFIDE-----IKSKGGRVFVHCHAGISRSATVCIAYLMQHK-KVTMTEAYKYVQSRRPI-ISPNLG
...     |  .|. |    .. .|||. |. ...||.|       ..||.| |||.||..|..|...|||| .. .|.. ||.|.....||  . ....
dltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtps

FMGQLMVH
.. .|. .
qyrflyea
PTEN_1 183-319 1.2e-37 124.7 In-house 35-185 (196) alignment 
Range on Protein: 183-319
Range on HMM: 35-185/196.0
P------EgtpvEILPFLYLGSAKDS-SDLRILKKMNITAVLNITTSCPN---------HFEPYLEYKSIPVEDTHQADLLSRLQTAINFIDEIKS--KG
.           || ..||.||.||  .||. ||...||.|.| .  ...         .|.  .||...|.|| .  .| . .  . .||. ..|  .|
apsrpllq....eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpng

GRVFVHCHAGISRSATVCIAYLMQHKKVTMTEAYKYVQSRRPIISPNLGFMGQLM
. | |||.||..||.||..||||...| |. || ..|...|| ..|| ... .|.
nvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerll
0046846 (Phosphotyrosine protein) phosphatases II 183-321 2.9e-34 113.7 In-house 8-168 (176) alignment 
Range on Protein: 183-321
Range on HMM: 8-168/176.0
PEGTPVEILPFLYLGSAK----------DSSDLRILKKMNITAVLNITTSC-----------PNHFEPYLEYKSIPVEDTHQADLlSRLQTAINFIDEIK
... ...|.. |.|||.             ..|. ||...||||.|.|.             |   .. ..|. .|..| .  || . |.....||.|  
ldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefireal

SKGGRVFVHCHAGISRSATVCIAYLMQH-KKVTMTEAYKYVQSRRP-IISPNLGFMGQLMVH
..||.| |||.|||.|..|...|||... | ... ||...|...||  . .. ... .|.  
keggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyef
subfamily_DSP6_pd Subfamily DSP6 184-327 2.2e-52 170.7 In-house 11-156 (158) alignment 
Range on Protein: 184-327
Range on HMM: 11-156/158.0
EGTPVEILPFLYLGSAKDSSDLRILKKMNITAVLNITTSCPNHFEP--YLEYKSIPVEDTHQADLLSRLQTAINFIDEIKSKGGRVFVHCHAGISRSATV
. .||||||.||||||||.|.| .|||..|  |||.|.  || ||    |.|. ||.|| ....| . .  ||.|||| .||   |.|||.|||||| ||
aefpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtv

CIAYLMQHKKVTMTEAYKYVQSRRPIISPNLGFMGQLMVHQKNLEL
..||||....... .||..|..|.. ||||. |||||. ....|.|
tlaylmkklalslndaydlvkkrksnisPnfnfmgqlldferslrl
subfamily_DSP10_pd Subfamily DSP10 186-326 3.6e-60 196.4 In-house 13-154 (159) alignment 
Range on Protein: 186-326
Range on HMM: 13-154/159.0
TPVEILPFLYLGSAKDSSDLRILKKMNITAVLNITTSCPNHFEP-YLEYKSIPVEDTHQADLLSRLQTAINFIDEIKSKGGRVFVHCHAGISRSATVCIA
  ...||||.|||.||..|| .|...|||||||.|||.||.||   |.|| |||.||.. .|  . . |..||.|...|| ||.|||.||||||||| ||
pasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvvia

YLMQHKKVTMTEAYKYVQSRRPIISPNLGFMGQLMVHQKNLE
|||.|.......|||.|...||||||||.|||||. . |.|.
YlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekeln
subfamily_DSP8_pd Subfamily DSP8 186-327 2.5e-45 147.9 In-house 14-156 (159) alignment 
Range on Protein: 186-327
Range on HMM: 14-156/159.0
TPVEILPFLYLGSAKDSSDLRILKKMNITAVLNITTSCPNH-FEPYLEYKSIPVEDTHQADLLSRLQTAINFIDEIKSKGGRVFVHCHAGISRSATVCIA
 | .||..||||| ||. .  .|.|..|. |||. .|||.  . .  ..  .||.|... .||  ......||| .||. |||.||..||||||||| ||
gptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaia

YLMQHKKVTMTEAYKYVQSRRPIISPNLGFMGQLMVHQKNLEL
|.|.. .... |||..|...|| ||||| |.|||. ..|.|.|
yimktlemsldeayrfvkekrptispnlnflgqLleyekelkl
0044763 (Phosphotyrosine protein) phosphatases II 186-325 1.5e-44 147.0 In-house 22-170 (178) alignment 
Range on Protein: 186-325
Range on HMM: 22-170/178.0
TPVEILPFLYLGSAKDSSDLRILKKMNITAVLNITTSCPNHFEPY---------LEYKSIPVEDTHQADLLSRLQTAINFIDEIK-SKGGRVFVHCHAGI
 ..||||.|||||. ...||. ||...||...|.|. ....|...         ..|. ||..| .  |||. .. ...||.|.  .|||.|.|||.||.
naseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGv

SRSATVCIAYLMQHKKVTMTEAYKYVQSRRPiISPNLGFMGQLMVHQKNL
.||.|...|||| . .... ||...|..||| |.|| |.. ||.  .. |
gRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrl
0048076 (Phosphotyrosine protein) phosphatases II 186-323 5.3e-40 131.7 In-house 3-140 (145) alignment 
Range on Protein: 186-323
Range on HMM: 3-140/145.0
TPVEILPFLYLGSAKDSSDLRILKKMNITAVLNITTSCPNHFEPYLEYKSIPVEDTHQADLLSRLQTAINFIDEIKSKGGRVFVHCHAGISRSATVCIAY
 | |||| |||||  . .||. ||...||.|||.|. ......  ..|  .|..| .  |||. |.....||.|. ..||.|.|||.||..|..|...||
wpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaay

LMQHKKVTMTEAYKYVQSRRPIISPNLGFMGQLMVHQK
|| ...|.. ||...|.|.||.. || |.. .|.  ..
lmlllgvsleealelvrsqrpgavpnpgqlrflyefel
0048179 (Phosphotyrosine protein) phosphatases II 186-323 3e-39 129.3 In-house 3-142 (144) alignment 
Range on Protein: 186-323
Range on HMM: 3-142/144.0
TPVEILPFLYLGSAKDSSDLRILKKMNITAVLNITTSCPNHFEPYL--EYKSIPVEDTHQADLLSRLQTAINFIDEIKSKGGRVFVHCHAGISRSATVCI
 |.|||| |||||  ...||  |||..||.|.|.|......|.     .|  .|..| .  |||. |.....||.|. ..||.|.|||.||..|..|...
npseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlva

AYLMQHKKVTMTEAYKYVQSRRPIISPNLGFMGQLMVHQK
|||| ...... ||...|.||||.. || |.. .|.  .|
aylmkklglsleealalvrsrrpgavpnpgqlrfLleyek
0041856 (Phosphotyrosine protein) phosphatases II 186-325 3.6e-38 126.3 In-house 18-172 (182) alignment 
Range on Protein: 186-325
Range on HMM: 18-172/182.0
TPVEILPFLYLGSAKD--------------SSDLRILKKMNITAVLNITtsCPNHFEPYL-----EYKSIPVEDTHQADllsrLQTAINFIDEIKSKGGR
 . .|.. ||||| ..               ..|| ||...||...|.|  .....  .|     .|. .|..| .  |    |.....||.|....||.
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggp

VFVHCHAGISRSATVCIAYLMQHKKVTMTEAYKYVQSRRP--IISPNLGFMGQLMVHQKNL
|.|||.||..|..|...|||| ...|...||.|.|.||||  .|.|| .|. ||..... |
vlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallelll
subfamily_STYXL1_pd Subfamily STYXL1 186-324 6.1e-32 104.0 In-house 10-152 (157) alignment 
Range on Protein: 186-324
Range on HMM: 10-152/157.0
TPVEILP-FLYLGSAKDSSDLRILKKMNITAVLNITTSCPNHFEPYLE---YKSIPVEDTHQADLLSRLQTAINFIDEIKSKGGRVFVHCHAGISRSATV
 |||.|| .||||  |.. . .| | . . |..|... . . ..   .      |.|||. .||||.||. |..||.. | .|  |.|  . ||||||.|
yPvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaav

CIAYLMQHKKVTMTEAYKYVQSRRPIISPNLGFMGQLMVHQKN
 ||||| .||.|. .||||..  .. . || .|. ||   .|.
iiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekq
PTPc_motif_SM00404 187-323 3.3e-46 151.7 In-house 2-139 (140) alignment 
Range on Protein: 187-323
Range on HMM: 2-139/140.0
PVEILPFLYLGSAKDSSDLRILKKMNITAVLNITTSCPN-HFEPYLEYKSIPVEDTHQADLLSRLQTAINFIDEIKSKGGRVFVHCHAGISRSATVCIAY
| .||| |||||.........|||..||.|.|.|.....   ..  ....||..|.....|.  |. ...||.....|||.|.||| ||.|||||..|||
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

LMQHKKVTMTEAYKYVQSRRPIISPNLGFMGQLMVHQK
||. ..... |||..|..|||||||||.|. ||. ..|
lmryrqlslaeayefvkerRpiispnlnfvrqLieyek
subfamily_Slingshot_pd Subfamily Slingshot 187-325 3.9e-39 127.7 In-house 19-157 (169) alignment 
Range on Protein: 187-325
Range on HMM: 19-157/169.0
PVEILPFLYLGSAKDSSDLRILKKMNITAVLNITTSCPNHFEPYLEYKSIPVEDTHQADLLSRLQTAINFIDEIKSKGGRVFVHCHAGISRSATVCIAYL
. .|  ..||||  ..|.|  ||..... .||.|  . |.|.  .||. | | |....|||.  ... .||.. |.|| .|.|||  |.||||.. ||| 
askifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviaya

MQHKKVTMTEAYKYVQSRRPIISPNLGFMGQLMVHQKNL
|.. .... ||..||..|| .| || ||. || ...  |
mkeyglsleealeyvkerrsvikPnkgflkqleeyeGil
0043147 (Phosphotyrosine protein) phosphatases II 187-326 3.9e-37 123.0 In-house 19-161 (172) alignment 
Range on Protein: 187-326
Range on HMM: 19-161/172.0
PVEILPFLYLGSAKDSSDLRILKKMNITAVLNITTS---CPNHFEPYLEYKSIPVEDTHQAdLLSRLQTAINFIDE--IKSKGGRVFVHCHAGISRSATV
| ..........  .....| ||...||...|.|.    ... .. ...|  .|..| .   ||. |. ...||||  ..|.||.| |||.||..|..|.
pdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtl

CIAYLMQhKKVTMTEAYKYVQSRRPIISPNLGFMGQLMVHQKNLE
..||||. ..... ||...|...||....| ... .|. ..| | 
vaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfeklll
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 187-321 9.4e-37 119.8 In-house 7-143 (148) alignment 
Range on Protein: 187-321
Range on HMM: 7-143/148.0
PVEILP-FLYLGSAKDSSDLRILKKMNITAVLNITTSCPNHFEPY-LEYKSIPVEDTHQADLLSRLQTAINFIDEIKSKGGRVFVHCHAGISRSATVCIA
| || . ||.||| |  .||  ||....|.. | | ...| ..   .||  ....|  . || .  ...|.|... |..|.|| ||.. |.|||. . ..
pseikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalall

YLMQHKKVTMTEAYKYVQSRRPIISPNLGFMGQLMVH
.|...|.|.. ||. .|.|.|. . |||||. ||   
wlidfkrvslkealalvkskrryvdpnlgfLkqLael
0049260 (Phosphotyrosine protein) phosphatases II 187-321 1.7e-34 114.0 In-house 8-145 (152) alignment 
Range on Protein: 187-321
Range on HMM: 8-145/152.0
PVEILPFLYLGSAKDSSDLRILKKMNITAVLNITTSCPN---HFEPYLEYKSIPVEDTHQADLLSRLQTAINFIDE-IKSKGGRVFVHCHAGISRSATVC
| |.......|.   ....| ||...||.....|. ...    .| | .|. .|..| .  ||   |. .. ||.. ...|||.|.|||.||..|..|..
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlv

IAYLMQhKKVTMTEAYKYVQSRRPIISPNLGFMGQLMVH
.||||  ..|.. ||...|...||.. || |.. .|.  
aaylml.lgvsleeavalvrekRpgavpnpgqlrflyef
0049772 (Phosphotyrosine protein) phosphatases II 187-325 2.6e-34 114.7 In-house 155-273 (314) alignment 
Range on Protein: 187-325
Range on HMM: 155-273/314.0
PveilpflylgSAKDSSDLRILKkmnitavlnitTSC--PNHFEPY-LEYKSIPVEDtHQADLLSRLQTAINFIDEIkSKGGRVFVHCHAGISRSAT-VC
.          .  . .||  ||           . .  |..|| . ..|. |||.| ..|.||. .. ...||.|  .|||.|.|||.||..|..| |.
g..........neptaadlellk...........eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvv

IAYLMQHKKVTMTEAYKYVQSRRPiISPNLGFMGQLMVHQKNL
.|||| . .|.. ||...|...|| |.|| ||. ||.  .. |
aaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefil
subfamily_LRR-DSP_pd Subfamily LRR-DSP 187-325 2.4e-32 106.1 In-house 120-258 (263) alignment 
Range on Protein: 187-325
Range on HMM: 120-258/263.0
PVEILPFLYLGSAKDSSDLRILKKMNITAVLNITTSCPNHFEPYLEYKSI-PVEDTHQADLLSRLQTAINFIDEIKSKGGrVFVHCHAGISRSATVCIAY
| ||.. |.||. . . .  |||....| .|   . .   |   . | ||  .||. .||.   ..    ||.| . ||| |.||| ||.|||.|. |.|
PdeiidklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGvsrsstlvisy

LMQHKKVTMTEAYKYVQSRRPIISPNLGFMGQLMVHQKNL
||....... ||.  |...|| | || ||. ||. ..|.|
lmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekkl
subfamily_DSP19_pd Subfamily DSP19 188-324 2e-45 148.8 In-house 13-149 (152) alignment 
Range on Protein: 188-324
Range on HMM: 13-149/152.0
VEILPFLYLGSAKDSSDLRILKKMNITAVLNITTSCPNHFEPYLEYKSIPVEDTHQADLLSRLQTAINFIDEIKSKGGRVFVHCHAGISRSATVCIAYLM
.|. | |||||    .| .|||. .|| .||..|  ||.|   ..|.||.. |. ..|||| |..|..||.| .|| |.|.|||.||.||||.| |||||
geveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylm

QHKKVTMTEAYKYVQSRRPIISPNLGFMGQLMVHQKN
........||...|.. || |.|| ||. ||  ....
kkeelsleealelvrearpcikPneGFikqLkeyeae
subfamily_DSP14_pd Subfamily DSP14 188-327 7.4e-43 140.2 In-house 8-146 (157) alignment 
Range on Protein: 188-327
Range on HMM: 8-146/157.0
VEILPFLYLGsAKDSSDLRILKKMNITAVLNITTSCPNHFEPYLEYKSIPVEDTHQADLLSRLQTAINFIDEIKSKGGRVFVHCHAGISRSATVCIAYLM
..| | |.|. .  ... . ||| .||...|.|.  ||.  . .|.  .||||...|.| . ...... |.|.| |||.. ||| ||.||||..|.||||
sqitpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylm

QHKKVTMTEAYKYVQSRRPIISPNLGFMGQLMVHQKNLEL
...|... ||||.|.|.||||.||.||  ||. . |.|. 
kyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkg
0036282 (Phosphotyrosine protein) phosphatases II 188-319 1.4e-29 98.4 In-house 13-163 (174) alignment 
Range on Protein: 188-319
Range on HMM: 13-163/174.0
VEILPFLYLGSAKDSsDLRILKKMNITAVLNITTSCPNH---------------FEPYLEYKSIPVEDTHQADLLSrLQTAINFIDEIKSK--GGRVFVH
..|.| |..|..  . ... ||. .||.|.. .......                .  ..|. .|..| .  ||   |.....|..|. |.  || | ||
syitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVH

CHAGISRSATVCIAYLMQHKKV-TMTEAYKYVQSRR---PIISPNLGFMGQLM
|.||..|..|...|||| . .  .. .|...|...|   | . .. ... .| 
CsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrfly
subfamily_DSP12_pd Subfamily DSP12 189-323 1.5e-39 129.9 In-house 4-141 (155) alignment 
Range on Protein: 189-323
Range on HMM: 4-141/155.0
EILPFLYLGSAKDSSDLRILKKMNITAVLNITTSC-PNHF--EPYLEYKSIPVEDTHQADLLSRLQTAINFIDEIKSKGGRVFVHCHAGISRSATVCIAY
.||| ||||....  . . ||...||.|| ...   |.|   . ....|.|.. |. ..|.|| |..|..||.|  ...| |.|||.||.|||.|..|||
rilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAY

LMQHKKVTMTEAYKYVQSRRPIISPNLGFMGQLMVHQK
||...|. ...|.| |.. .| |.|| ||. || ...|
lmkkeklslekAlklvkekkpeiepNegFleQLklfek
subfamily_DSP15_pd Subfamily DSP15 189-323 9.9e-37 120.3 In-house 4-137 (151) alignment 
Range on Protein: 189-323
Range on HMM: 4-137/151.0
EILPFLYLGSAKDSSDLRILKKMNITAVLNITTSCPNHFEPyLEYKSIPVEDTHQADLLSRLQTAINFIDEIKSKGGRVFVHCHAGISRSATVCIAYLMQ
..|| ||||  .||.|   ||. ||| .|..  .  ....  .||| |...|| .|.| . .. ...|| . ..|.. |.||| ||.|||.|...|||| 
kvlpglylgnfrdskdeelLkeknithilsvhdnakkllkd.ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmt

HKKVTMTEAYKYVQSRRPIISPNLGFMGQLMVHQK
  ..   .| . .. .| .  ||.||  ||....|
vtelnwrdalevikaaRsvanPnfGfkrqlkeyek
subfamily_DSP3_pd Subfamily DSP3 189-326 1.5e-33 109.7 In-house 13-158 (162) alignment 
Range on Protein: 189-326
Range on HMM: 13-158/162.0
EILPFLYLGSAKDSSDLRILKKMNITAVLNITTSC-------PNHFE-PYLEYKSIPVEDTHQADLLSRLQTAINFIDE-IKSKGGRVFVHCHAGISRSA
|. | ||.| .. ..| . |||. || ||| . .        .....   ..|  ..|.|. ..||    .|| .|||| ...| |.|.|||..|.||||
evypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsa

TVCIAYLMQHKKVTMTEAYKYVQSRRPIiSPNLGFMGQLMVHQKNLE
|. .|||| ..|.|..|| . |...| |  || ||. ||.  ...|.
tlvlayLmirrkmtlveairtvrkkRei.lPneGFlkqLaeldeelk
0051082 (Phosphotyrosine protein) phosphatases II 189-320 2.9e-27 90.5 In-house 10-148 (151) alignment 
Range on Protein: 189-320
Range on HMM: 10-148/151.0
EILPFLYLGSAKDSSDLRILKKMNITAVLNITT-----SCPNHFEP-YLEYKSIPVEDTHQADLLSRLQTAINFIDEIKSK-GGRVFVHCHAGISRSATV
 . ..||....  . .|. ||...|....|...      ||. ..   .|.. ||..|..  .|   ......|.... .| .| |.|||.||..|..|.
yvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtl

CIAYLMQhKKVTMTEAYKYVQSRRP-IISPNLGFMGQLMV
...|||   .|.. ||.......|| .. || .|. ||..
valylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfa
subfamily_STYX_pd Subfamily STYX 189-323 6.1e-27 87.7 In-house 14-155 (166) alignment 
Range on Protein: 189-323
Range on HMM: 14-155/166.0
EILPFLYLG--SAKDSSDLRILKKMNITAVLNITTSCP-----NHFEPYLEYKSIPVEDTHQADLLSRLQTAINFIDEIKSKGGRVFVHCHAGISRSATV
|||| |.||  ||   | | .|||  || .. |  .         |.  . |  . | |.   ...  | |  .|||.  .|||.|.||  |||||||..
eilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaal

CIAYLMQHKKVTMTEAYKYVQSRRPIISPNLGFMGQLMVHQK
 |||.|.   .   ||..||| ||  |.|| ||. ||.... 
viayimetyglkyreafayvqerrfcinpnegfvsqlkeyea
0042113 (Phosphotyrosine protein) phosphatases II 189-319 1.4e-26 88.8 In-house 49-236 (245) alignment 
Range on Protein: 189-319
Range on HMM: 49-236/245.0
EILPFLYLGSAKDSSDLR----ILKKMNITAVLNITTSCPNHFEP----------------------------------------------YLEYKSIPV
.| | ......  ....      |.. .||.....|.  .....                                                . |  .|.
ritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpw

EDTHQADLLSRLQTAINFIDEIKS--KGGRVFVHCHAGISRSATVCIAYLM-----QHKKVTMTEAYKYVQSRRPIISPNLGFMGQLM
.| . .|||. |. ...|.... .  ..|.|.|||.||..|..|...||||      ...|.. ||.|...|.|| . ...... .|.
pdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrfly
subfamily_MKPLT_pd Subfamily MKPLT 193-321 2.2e-35 115.6 In-house 28-156 (164) alignment 
Range on Protein: 193-321
Range on HMM: 28-156/164.0
FLYLGSAKDSSDLRILKKMNITAVLNITTSCPNHFEPYLEYKSIPVEDTHQADLLSRLQTAINFIDEIKSKGGRVFVHCHAGISRSATVCIAYLMQHKKV
 |||| ||.. . ..||...|| ..|... . . |   .||  . |||. .  | | |. | .|. .    ||||.|||  | |||..| .|.|.. |. 
tlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgw

TMTEAYKYVQSRRPIISPNLGFMGQLMVH
|. |||.|.. || |..|| ||. ||  .
tlkeayeylkerrsivapnrGflkqlakf
subfamily_MKPLV_pd Subfamily MKPLV 193-321 2.2e-35 115.6 In-house 28-156 (164) alignment 
Range on Protein: 193-321
Range on HMM: 28-156/164.0
FLYLGSAKDSSDLRILKKMNITAVLNITTSCPNHFEPYLEYKSIPVEDTHQADLLSRLQTAINFIDEIKSKGGRVFVHCHAGISRSATVCIAYLMQHKKV
 |||| ||.. . ..||...|| ..|... . . |   .||  . |||. .  | | |. | .|. .    ||||.|||  | |||..| .|.|.. |. 
tlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgw

TMTEAYKYVQSRRPIISPNLGFMGQLMVH
|. |||.|.. || |..|| ||. ||  .
tlkeayeylkerrsivapnrGflkqlakf
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 193-325 2.8e-28 92.2 In-house 9-152 (154) alignment 
Range on Protein: 193-325
Range on HMM: 9-152/154.0
FLYLGSAKDSSDLRILKKMNITAVLNITTSCPNHFEPY---------LEYKSIPVEDTHQADLLSRLQTAINFIDEIK--SKGGRVFVHCHAGISRSATV
|||..| . . .   |.. ||. .||. .  .| |            .||  . . |  . |.. .|. | .|||.     . ..|.||...|.||||..
flyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaal

CIAYLMQHKKVTMTEAYKYVQSRRPIISPNLGFMGQLMVHQKNL
 |.|||...|... .|.. ... |.||.|| ||. || ...|.|
lisylmdklkislslalellkdsryiikPnqGflkqleifekel
0051429 (Phosphotyrosine protein) phosphatases II 193-331 2.9e-22 75.1 In-house 22-230 (272) alignment 
Range on Protein: 193-331
Range on HMM: 22-230/272.0
F-LYLGSAK---DSSDLRILKKMNITAVLNITTSCPNHFEP------YLEYKSIPVEDTHQADLLSRL--------------------------------
  ||....    .  |.. ||...|........ .   ...       ..|  .|..|..  . |                                   
grlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsageare

----------------QTAINFIDEIKSkGGRVFVHCHAGISRSATVCIAYLMQhKKVT--------------MTEAYKYVQSRRPIISPNLGFMGQLMV
                .. ....... . ||.| |||.||..|..||. ..|.    |.              . ||.......|| . .. ... .|. 
vmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflye

HQKNLELHWTT
  ..|   ...
allellrslls
DSPc Dual specificity phosphatase, catalytic domain 194-323 1.7e-44 145.9 Pfam-A 1-132 (133) alignment 
Range on Protein: 194-323
Range on HMM: 1-132/133.0
LYLGSAKDSSdLRILKKMNITAVLNITTSCPN-HF--EPYLEYKSIPVEDTHQADLLSRLQTAINFIDEIKSKGGRVFVHCHAGISRSATVCIAYLMQHK
|||||....| |..|.|..||.|.|.|...|| ..  ..  || .|||||...... . |. |..||.....||..|.||| ||||||||..|||||. |
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

KVTMTEAYKYVQSRRPIISPNLGFMGQLMVHQK
.....|||..|..||..|||| ||..||. ...
nlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 194-323 1.7e-44 145.9 In-house 1-132 (133) alignment 
Range on Protein: 194-323
Range on HMM: 1-132/133.0
LYLGSAKDSSdLRILKKMNITAVLNITTSCPN-HF--EPYLEYKSIPVEDTHQADLLSRLQTAINFIDEIKSKGGRVFVHCHAGISRSATVCIAYLMQHK
|||||....| |..|.|..||.|.|.|...|| ..  ..  || .|||||...... . |. |..||.....||..|.||| ||||||||..|||||. |
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

KVTMTEAYKYVQSRRPIISPNLGFMGQLMVHQK
.....|||..|..||..|||| ||..||. ...
nlslneAyefvkerrskispnagflrqLleyer
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 194-325 4.5e-23 75.0 In-house 6-141 (145) alignment 
Range on Protein: 194-325
Range on HMM: 6-141/145.0
LYLGSAKDSSDLRILKKMNITAVLNITTS----CPNHFEPYLEYKSIPVEDTHQADLLSRLQTAINFIDEIKSKGGRVFVHCHAGISRSATVCIAYLMQH
|| |||  ..|. .|... |. ..|....    . .     .|   |  || .  ||   ..   .|||  | .|  ||||| ||.||| || .|.||..
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

KKVTMTEAYKYVQSRRPIISPNLGFMGQLMVHQKNL
 ..|..|| . |.|.|    ||. |. .|.  .|.|
cnmtlseaarqvrsnrllaypnvtflknllnlekql
0038934 (Phosphotyrosine protein) phosphatases II 199-326 6.3e-23 76.9 In-house 43-177 (194) alignment 
Range on Protein: 199-326
Range on HMM: 43-177/194.0
AKDSSDLRILKKMNITAVLNITTSC----PNHFEP-YLEYKSIPVEDTHQADLLSRLQTAINFIDEIKSK--GGRVFVHCHAGISRSATVCIAYLMQHKK
 .|  ..  |.......|...| .     |..||   .|| ..|..| . .  |. |.. ....||. ..  || | |||.||..|..|...|||... .
pedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlg

VTMTEAYKYVQSRRPIISPNLGFMGQLMVHQKNLE
 .. ||.......|| . || ... .|... |.|.
msaeeAialfrekRpgaipnqdyleallkrykelr
0040439 (Phosphotyrosine protein) phosphatases II 203-319 1.3e-28 95.7 In-house 69-239 (249) alignment 
Range on Protein: 203-319
Range on HMM: 69-239/249.0
SDLRILKKMNITAVLNITTSCPN-------------------------------------------HFEPYLEYKSIPVEDTHQADLLSRLQTAINFIDE
...| |.. .||.....|. ...                                            . . .... |.. | .  .. . ......||..
dfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfiea

IKS------KGGRVFVHCHAGISRSATVCIAYLM-----QHKKVTMTEAYKYVQSRRPIISPNLGFMGQLM
...      |||.|.|||.||..|..|...||||      ...|.. ||.|...|.|| . .|.... .|.
vrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrfly
subfamily_DSP23_pd Subfamily DSP23 203-306 1e-10 36.5 In-house 22-126 (148) alignment 
Range on Protein: 203-306
Range on HMM: 22-126/148.0
SDLRILKKMNITAVLNITTSCPNHFE--PYLEYKSIPVEDTHQAdLLSRLQTAINFIDEIKSKGGRVFVHCHAGISRSATVCIAYLMQHKKVTMTEAYKY
...| |  . .  .. .|. .. | |  | | .. . ..| |    | ...  .. ..| ..|.  | |||  |  |. |.   ||....|.. .||   
dqyrylldlgvrylvslteegrphveatpnltlvrlriddyhpp.aleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiae

VQSRRP
|. .||
vrrlrp
0039614 (Phosphotyrosine protein) phosphatases II 205-321 2.8e-24 81.6 In-house 118-284 (297) alignment 
Range on Protein: 205-321
Range on HMM: 118-284/297.0
LRILKKMNITAVLNITTSCPNHF--------------------------------------------EPYLEYKSIPveDTHQADLLSRLQTAINFIDEI
.| ... ..|.....|. ...                                                 . | ..|  | .  ..|. |. ......|.
wrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwp..dhgvppslellleflelvrea

KS---KGGRVFVHCHAGISRSATVCIAYLM-----QHKKVTMTEAYKYVQSRRPIISPNLGFMGQLMVH
 .   |||.| |||.||..|..|...||||      ...|.. ||.|.....|| . ...... .|.  
laelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflyda
0036941 (Phosphotyrosine protein) phosphatases II 205-330 9.3e-23 76.4 In-house 37-281 (297) alignment 
Range on Protein: 205-330
Range on HMM: 37-281/297.0
LR----------------------------------------------------------ILKKMNITAVLNITTSCPNHFEPYLEYKSIP---------
..                                                           . . |.| ....|.  .. .| . .| .           
penleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygd

----------------------VED----------------THQADLLSRLQTAINFIDEIKS------KGGRVFVHCHAGISRSATVCIAYLM------
                      |.|                    .. .  .. ..||.....      .||.| |||.||..||.|...|.||      
ftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqled

--QHKKVTMTEAYKYVQSRRPIISPNLGFMGQLMVHQKNLELHWT
   ...|.. ||.|.. ..|| . ..|... .|     .| .. .
klkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl
0045450 (Phosphotyrosine protein) phosphatases II 206-319 9.3e-28 93.3 In-house 125-297 (307) alignment 
Range on Protein: 206-319
Range on HMM: 125-297/307.0
RILKKMNITAVLNITTSCPN-----------------------------HfEPYLEYKSIPVEDT-----------------HQADLLSRLQTAINFIDE
| |.. ..|.....|.....                             | .... .  ..|.|.                    .. . ......||.|
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfiee

IKS------KGGRVFVHCHAGISRSATVCIAYLMQHKK--------VTMTEAYKYVQSRRPIISPNLGFMGQLM
...      |||.| |||.||..|..|...|||| .          |.. ||.|.....|| . .|.... .|.
vrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrfly
0040438 (Phosphotyrosine protein) phosphatases II 206-324 1.1e-24 82.7 In-house 104-274 (317) alignment 
Range on Protein: 206-324
Range on HMM: 104-274/317.0
RILKKMNITAVLNITTSCPNH---------------------------FEPYLEYKSIPVEDT----------------HQADLLSRLQTAINFIDEIKS
| ... ..| ....|.....                             ... ..  ..|||.                   .. . ... ..|......
rmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavre

K----GGRVFVHCHAGISRSATVCIAYLM-----QHKKVTMTEAYKYVQSRRPIISPNLGFMGQLMVHQKN
.    || | |||.||..|..|...||||     ....|...||.|.....|| . ...... .|.    .
aledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalle
0043336 (Phosphotyrosine protein) phosphatases II 206-319 9.8e-20 66.6 In-house 106-270 (278) alignment 
Range on Protein: 206-319
Range on HMM: 106-270/278.0
RILKKMNITAVLNITTSC-----------------------------------------------PNHFEPYLEYKSIPveDTHQADLLSRLQTAINFID
| ... ..| ....|.                                                 . ..   . |...|  | .  . || |.  .....
rmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp..dhgvpeslsllldflkavr

EIK-SKGGRVFVHCHAGISRSATVCIAYLM-----QHKKVTMTEAYKYVQSRRPIISPNLGFMGQLM
|.  ...| | |||.||..|..|....||.      ...|.. ||.|.....|| . ... .. .| 
ealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrfly
subfamily_MSG5_pd Subfamily MSG5 212-325 1.1e-18 60.9 In-house 47-160 (165) alignment 
Range on Protein: 212-325
Range on HMM: 47-160/165.0
NITAVLNITTSCPNH--FEPYLEYKSIpvEDTHQADLLSRLQTAINFIDEIKSKGGRVFVHCHAGISRSATVCIAYLMQHKKVTMTEAYKYVQSRRPIIS
..  |.|..   ..     | ..|  |  | .|.. .   | .  . |   .||. ...|||  |.||||.. .||.|.. .... .||. ..|.   ||
sfdlvinvakeindlellvpavkyyhi..ewehdskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddis

PNLGFMGQLMVHQKNL
|..|.. |||  .  |
psiglifqlmeweval
0047943 (Phosphotyrosine protein) phosphatases II 213-318 3.9e-17 58.0 In-house 102-264 (273) alignment 
Range on Protein: 213-318
Range on HMM: 102-264/273.0
ITAVLNITTSCPNHFEPYLEYKSIPVED----------------------------------------------THQADLLSRLQTAINFIDEIKS----
.. .  .|.   .. | .  | .  ...                                                  .  . |.  ..||.....    
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalea

--KGGRVFVHCHAGISRSATVCIAYLM-----QHKKVTMTEAYKYVQSRRPIISPNLGFMGQL
  ..| | |||.||..|..|.....|.      ...|.. ||.|...|.|| . ... .. .|
lpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
subfamily_PTPMT1_pd Subfamily PTPMT1 230-310 4.2e-21 70.1 In-house 73-153 (171) alignment 
Range on Protein: 230-310
Range on HMM: 73-153/171.0
YLEYKSIPVEDTHQADLLSRLQTAINFIDEIKSKGGRVFVHCHAGISRSATVCIAYLMQHKKVTMTEAYKYVQSRRPIISP
 .|. .... |  .|  | .|. ...||....||| ||.|||.|| .||||. ..|||...|... || |.....|.||  
gveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirl
0046845 (Phosphotyrosine protein) phosphatases II 230-308 1.4e-13 46.3 In-house 169-256 (284) alignment 
Range on Protein: 230-308
Range on HMM: 169-256/284.0
YLEYKSIPveDTHQADLlsrLQTAINFIDEIKSK------GGRVFVHCHAGISRSATVCIAYLMQHK--------KVTMTEAYKYVQSRRPII
.. |.|.|  | .  .    ..  ..|......       || . |||.||..|..|.....|. .         .|.. ||.|.. ..||  
hfhytswp..dhgvpps...pedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgm
subfamily_Laforin_pd Subfamily Laforin 231-308 1.7e-09 30.8 In-house 77-154 (183) alignment 
Range on Protein: 231-308
Range on HMM: 77-154/183.0
LEYKSIPVEDTHQADLLSRLQTAINFIDEIKSKGGRVFVHCHAGISRSATVCIAYLMQHKKVTMTEAYKYVQSRRPII
| |  .|.||      .  |  |. ..  .  || .|.||| ||. ||...   .|.   . ...    .. ..||..
layiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvv
subfamily_PTEN_pd Subfamily PTEN 235-305 2.3e-06 22.7 In-house 84-156 (184) alignment 
Range on Protein: 235-305
Range on HMM: 84-156/184.0
SIPVEDtHQADLLSRLQTAINFIDEIKS--KGGRVFVHCHAGISRSATVCIAYLMQHKKVTMT-EAYKYVQSRR
 .|..| |..  |. |..... |..  .  |   | |||.||  |. .. .|||....... . || .. .. |
vypfdD.hnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaR
PTPc_DSPc_SM00012 237-290 2.1e-08 29.6 In-house 16-65 (105) alignment 
Range on Protein: 237-290
Range on HMM: 16-65/105.0
PVEDTHQADLLSRLQTAINFIDEikskGGRVFVHCHAGISRSATVCIAYLMQHK
| | ..  .||  ...  | ...    .. | |||.||..|..|.. .... ..
Peesdsilellravkknknkses....skpvvVhCsaGvgRtgtfvaldillqq
0051299 (Phosphotyrosine protein) phosphatases II 239-312 4.1e-15 51.5 In-house 190-272 (288) alignment 
Range on Protein: 239-312
Range on HMM: 190-272/288.0
EDTHQADLLSRLQTAINFIDEIKSK----GGRVFVHCHAGISRSATVCIAYLM-----QHKKVTMTEAYKYVQSRRPIISPNL
 .    .  . ..  ..|. .....    || | |||.||..|..|.....|.     ....|.. ||.|.. ..|| . ...
tnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp
0050432 (Phosphotyrosine protein) phosphatases II 243-311 1.6e-14 49.4 In-house 209-284 (308) alignment 
Range on Protein: 243-311
Range on HMM: 209-284/308.0
QADLLSRLQTAINFIDEIKSK--GGRVFVHCHAGISRSATVCIAYLM-----QHKKVTMTEAYKYVQSRRPIISPN
  .  . ..  ..|.......  || . |||.||..|..|.....|.     ....|.. ||.|.. ..||   ..
dhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqt
subfamily_PTPDC1_pd Subfamily PTPDC1 248-306 1.7e-09 32.4 In-house 99-156 (182) alignment 
Range on Protein: 248-306
Range on HMM: 99-156/182.0
SRLQTAINFIDEIKSKGgRVFVHCHAGISRSATVCIAYLMQHKKVTMTEAYKYVQSRRP
 |. . .  ..   ..| .| ||||||  |   .  .||. .|..|  .| | |.|.||
eriLdivkvvafalqeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrp
Y_phosphatase Protein-tyrosine phosphatase 249-304 1.6e-06 23.1 Pfam-A 151-215 (235) alignment 
Range on Protein: 249-304
Range on HMM: 151-215/235.0
RLQTAINFIDEIKSKG----GRVFVHCHAGISRSATVCIAYLMQHK-----KVTMTEAYKYVQSR
  .  ...|......     | | ||| ||..|..|.. . .. ..     .| . .. | ....
spkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkq
Y_phosphatase Protein-tyrosine phosphatase 249-304 1.6e-06 23.1 In-house 151-215 (235) alignment 
Range on Protein: 249-304
Range on HMM: 151-215/235.0
RLQTAINFIDEIKSKG----GRVFVHCHAGISRSATVCIAYLMQHK-----KVTMTEAYKYVQSR
  .  ...|......     | | ||| ||..|..|.. . .. ..     .| . .. | ....
spkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkq
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 250-305 5.1e-07 24.1 In-house 177-238 (290) alignment 
Range on Protein: 250-305
Range on HMM: 177-238/290.0
LQTAINFIDEIKSKGGRVFVHCHAGISRSAT---VCIAYLMQH---KKVTMTEAYKYVQSRR
 .|... |. .| ..  | |||. ||||||.   . ..| .     ..|..... |.....|
tktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqr
DSPc_SM00195 250-290 3.4e-06 21.9 In-house 177-221 (263) alignment 
Range on Protein: 250-290
Range on HMM: 177-221/263.0
LQTAINFIDEIKSK----GGRVFVHCHAGISRSATVCIAYLMQHK
 .  .... ..|..     | . |||.||..|..|.. . .. .|
tksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilsk
PTPc_SM00194 250-290 3.4e-06 21.9 In-house 177-221 (263) alignment 
Range on Protein: 250-290
Range on HMM: 177-221/263.0
LQTAINFIDEIKSK----GGRVFVHCHAGISRSATVCIAYLMQHK
 .  .... ..|..     | . |||.||..|..|.. . .. .|
tksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilsk
0048567 (Phosphotyrosine protein) phosphatases II 252-306 1.2e-09 32.7 In-house 62-119 (157) alignment 
Range on Protein: 252-306
Range on HMM: 62-119/157.0
TAINFIDEIKSKGGRVFVHCHAGI---SRSATVCIAYLMQHKKVTMTEAYKYVQSRRP
 . .|.. .. .|... |||.||    .|.||.. .||. | . |  ||.....  ||
klnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrp
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 252-288 3.3e-06 21.3 In-house 197-234 (307) alignment 
Range on Protein: 252-288
Range on HMM: 197-234/307.0
TAINFIDEIKSKGGRVFVHCHAGISRSATV-CIAYLMQ
||||... .. .   | ||| ||. || |. .|.....
tainlleavrydtnpvvvhcsaGvGrsGtivaislvqd
subfamily_CDC14_pd Subfamily CDC14 255-315 7.7e-09 29.8 In-house 254-316 (328) alignment 
Range on Protein: 255-315
Range on HMM: 254-316/328.0
NFIDEIKSKGGRVFVHCHAGISRSATVCIAYLMQHKKVTMTEAYKYVQSRRP--IISPNLGFM
.|.. ...  | . |||.||. |  |.  .|||.| ..| .||  ...  ||  .|.|   |.
kfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGsvigpqqkfl
subfamily_RNGTT_pd Subfamily RNGTT 255-306 9.2e-06 19.5 In-house 106-155 (189) alignment 
Range on Protein: 255-306
Range on HMM: 106-155/189.0
NFIDeiKSKGGRVFVHCHAGISRSATVCIAYLMQHKKVTMTEAYKYVQSRRP
.|..  |.    . |||. |  |.  . ..||...... . .| .  .. ||
effk..knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRp