Gene DSP19 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP19
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP009_AA protein Get Run
AqueP009_AA_70-214 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
PTEN_1 55-213 6.4e-27 89.6 In-house 26-191 (196) alignment 
Range on Protein: 55-213
Range on HMM: 26-191/196.0
QQEGKSLGFCPDLRPDKeigVALPRLFIASQDVA-YDKSALSVLGVTHILNVAADLPN---------AFPSDYVYCSVPMYDDEDEVLMQHYSKCQDFID
  .    |..|.. . .    . ..|.. |.. .  |.  |   |.|...|.. . ..         .| |.. | ..|. |.    | ..   | .||.
tsriiamgkapsrpllq...eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfie

EALSKE-DGRLLVHCRAGRSRSVSIAVAYMMHKDKsLTVEEALGKIRETRPNADPNAGFFKQLKALEIEL
 .||..  .  ||||.||..||. .. ||.|.| | ||..|||  .|| ||.. || .. ..|.  . ||
wllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapnspsqerlleyfael
subfamily_DSP19_pd Subfamily DSP19 62-214 7.4e-63 205.4 In-house 1-151 (152) alignment 
Range on Protein: 62-214
Range on HMM: 1-151/152.0
GFCPDLRPDKEIGVALPRLFIASQDVAYDKSALSVLGVTHILNVAADLPNAFPSDYVYCSVPMYDDEDEVLMQHYSKCQDFIDEALSKEdGRLLVHCRAG
||..||..|.|.|.. |||...|||||.||..|.  ..|||||||...||.||.|. |.|....|.... |........|||.||.||. |..||||.||
gfveDlkedlevgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskd.gavlvHCnAG

RSRSVSIAVAYMMHkDKSLTVEEALGKIRETRPNADPNAGFFKQLKALEIELQ
.|||.|...||.|. ...|..|||| ..||.||...||.||.||||..|.||.
vSRsasvviaylmk.keelsleealelvrearpcikPneGFikqLkeyeaell
subfamily_STYX_pd Subfamily STYX 72-211 2.5e-18 59.7 In-house 11-155 (166) alignment 
Range on Protein: 72-211
Range on HMM: 11-155/166.0
EIGVALPRLFIASQDVAyDKSALSVL---GVTHILNVAAD-----LPNAFPSDYVYCSVPMYDDEDEVLMQHYSKCQDFIDEALSKeDGRLLVHCRAGRS
|.   || ||.     |  || | ||   |.|||. .  .     .   || .. |  . . |.  | ..... . ..|||..|.|  |..|||  || |
emqeilpglflgpysaa.mksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqk.ggkvlvhgnagis

RSVSIAVAYMMHKdKSLTVEEALGKIRETRPNADPNAGFFKQLKALEI
|| .. .||.|     |   ||   ..| |   .||.|| .|||  |.
rsaalviayimet.yglkyreafayvqerrfcinpnegfvsqlkeyea
subfamily_DSP3_pd Subfamily DSP3 75-214 2.4e-35 115.6 In-house 13-158 (162) alignment 
Range on Protein: 75-214
Range on HMM: 13-158/162.0
VALPRLFIASQDVAYDKSALSVLGVTHILNVAAD-L------PNAFP-SDYVYCSVPMYDDEDEVLMQHYSKCQDFIDEALSKEDGRLLVHCRAGRSRSV
   |.|... ..|| ||| |  ||.||.|| |.  .      .. .  ..  |. ... |     | .....  .|||||||...|..||||..| ||| 
evypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsa

SIAVAYMMHKdKSLTVEEALGKIRETRpNADPNAGFFKQLKALEIELQ
 ...||.| . ...|. ||. ..|. | .  || ||.|||..|. ||.
tlvlayLmir.rkmtlveairtvrkkR.eilPneGFlkqLaeldeelk
subfamily_DSP10_pd Subfamily DSP10 75-214 7.4e-32 104.4 In-house 16-154 (159) alignment 
Range on Protein: 75-214
Range on HMM: 16-154/159.0
VALPRLFIASQDVAYDKSALSVLGVTHILNVAADLPNAFPS-DYVYCSVPMYDDEDEVLMQHYSKCQDFIDEAlSKEDGRLLVHCRAGRSRSVSIAVAYM
  || ||. |.  | |..||  |..|..|||....|| |   .  |  .|. | . . | |.. .  .||.||  |.. |.||||.|| |||.....||.
qvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieea.rkkgsrvLvhCqaGisrsatvviaYl

MHkDKSLTVEEALGKIRETRPNADPNAGFFKQLKALEIELQ
|.  ..|....|   ..|.||   || .|  ||. .| ||.
mk.hlnlslndaykfvkekrpiisPnLnfmGqLlefekeln
subfamily_DSP8_pd Subfamily DSP8 75-213 8.7e-27 87.6 In-house 17-154 (159) alignment 
Range on Protein: 75-213
Range on HMM: 17-154/159.0
VALPRLFIASQDVAYDKSALSVLGVTHILNVAADLPN-AFPSDYVYCSVPMYDDEDEVLMQHYSKCQDFIDEALsKEDGRLLVHCRAGRSRSVSIAVAYM
  |. |.. || .. ....|| ||....||.    |.  . ..  .  ||. |. || |.. . |  .||| |  .|.|| |||. ||.||| ..|.||.
rilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkak.sengrvlvhvlaGisrsatvaiayi

MhKDKSLTVEEALGKIRETRPNADPNAGFFKQLKALEIEL
| |  .....||   ..| ||  .||  | .||   | ||
m.ktlemsldeayrfvkekrptispnlnflgqLleyekel
0045098 (Phosphotyrosine protein) phosphatases II 75-213 6.5e-23 76.9 In-house 24-271 (278) alignment 
Range on Protein: 75-213
Range on HMM: 24-271/278.0
VALPRLFIASQD-----------------------------------------VAYDKSALSVLGVTHILNVA---------------------------
  .| |.. ..|                                         || .   |  ||.|.|....                           
eitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftv

-------------------------ADLPNAFPSDYVYCSVPMYDDEDEVLMQHYSKCQDFIDEALSK-------------EDGRLLVHCRAGRSRSVSI
                         .||....   . | ..| ..  .. ....  .. .||.|||..             ..|. ||||.|| .|.  .
tllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtl

AVAYMMHKD--KSLTVEEALGKIRETRPN-ADPNAGFFKQLKALEIEL
..||.| .   . ....||. ..|. ||. | .| .....|  ...||
vaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllel
subfamily_DSP15_pd Subfamily DSP15 76-210 5.2e-28 92.0 In-house 5-136 (151) alignment 
Range on Protein: 76-210
Range on HMM: 5-136/151.0
ALPRLFIASQDVAYDKSALSVLGVTHILNVAaDLPNAFPSDYVYCSVPMYDDEDEVLMQHYSKCQDFIDEALSKEDGrLLVHCRAGRSRSVSIAVAYMMH
 || |...   .. |.  |.   .||||.|  | .. .  |  |  ... |  .  |....... .|| .. .||..  |||| || |||| ..|||.| 
vlpglylgnfrdskdeelLkeknithilsvh.dnakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeen.vlvhClaGvsRsvtlvvaYlmt

KdKSLTVEEALGKIRETRPNADPNAGFFKQLKALE
   .|  ..||  |...|  |.||.|| .|||  |
v.telnwrdalevikaaRsvanPnfGfkrqlkeye
0051429 (Phosphotyrosine protein) phosphatases II 76-212 1.5e-18 62.9 In-house 19-223 (272) alignment 
Range on Protein: 76-212
Range on HMM: 19-223/272.0
ALPRLFIASQDV----AYDKSALSVLGVTHILNVAADLPNAFPS------DYVYCSVPMYDDEDEVLMQHY-----------------------------
 .|.....|.      | |  .|  ||...|...  .   ..        .  |. .|..||...   ...                             
vkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsage

-------------------SKCQDFIDEALSkeDGRLLVHCRAGRSRSVSIAVAYMMHKDKSLT------------VEEALGKIRETRPNADPNAGFFKQ
                   . . ..... |.  .|..||||.||..|.  .......  . ||.            .|||. ..|. ||.| .. .....
arevmhlhytdwpdhgvpqeallellellld..ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylf

LKALEIE
|   ..|
lyealle
subfamily_DSP1_pd Subfamily DSP1 77-214 9.9e-34 110.8 In-house 22-157 (163) alignment 
Range on Protein: 77-214
Range on HMM: 22-157/163.0
LPRLFIASQDVAYDKSALSVLGVTHILNVAADLPNAFPSDYVYCSVPMYDDEDEVLMQHYSKCQDFIDEAlSKEDGRLLVHCRAGRSRSVSIAVAYMMHK
|. |.. |. || ... |. ||.|.||||...|.|.|.. . | .... | ... .......  .||||.  |..|..|.||.|| ||| .. .||.|..
ldfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidev.kkknGkvlihCqaGisRsstlclaylmkt

DKsLTVEEALGKIRETRPNADPNAGFFKQLKALEIELQ
.. ...|||   ... |.   ||||| .||.  |..|.
kr.vsleeafdfvkqrRsiisPnagFvlqLlnyekkll
0044763 (Phosphotyrosine protein) phosphatases II 77-214 1.5e-32 108.0 In-house 27-171 (178) alignment 
Range on Protein: 77-214
Range on HMM: 27-171/178.0
LPRLFIASQDVAYDKSALSVLGVTHILNVAADLPNAFPSD---------YVYCSVPMYDDEDEVLMQHYSKCQDFIDEALSKEDGRLLVHCRAGRSRSVS
||.|...|.  | |.  |  ||.|||.|.. .|.. |...         . |. .|. |. .  |..|  .. .||.|||....|. ||||.||..|| .
lpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgt

IAVAYMMHKDkSLTVEEALGKIRETRPnADPNAGFFKQLKALEIELQ
...||.|.|  .|..|||.  .|| || . || |. .||. .| .|.
lvaaylmkkl.glsleeaielvrerRp.ivpnpgqlrqLyefelrll
subfamily_DSP12_pd Subfamily DSP12 77-209 1.8e-32 106.9 In-house 6-139 (155) alignment 
Range on Protein: 77-209
Range on HMM: 6-139/155.0
LPRLFIASQDVAYDKSALSVLGVTHILNVAAD-LP--NAFPSDYVYCSVPMYDDEDEVLMQHYSKCQDFIDEALsKEDGRLLVHCRAGRSRSVSIAVAYM
||.|....   . ... |. |..||.| |.   ||  .. ..   . .....|...| ...|. .. |||.||| .|.| .|||| || ||||.| .||.
lpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieeal.eeegavlvHCqagvSRSvtiviAYl

MHKDKsLTVEEALGKIRETRPNADPNAGFFKQLKAL
|.|.| | .|.|| ...| .|.. ||.|| .|||  
mkkek.lslekAlklvkekkpeiepNegFleQLklf
subfamily_DSP6_pd Subfamily DSP6 77-214 4.4e-31 101.5 In-house 18-155 (158) alignment 
Range on Protein: 77-214
Range on HMM: 18-155/158.0
LPRLFIASQDVAYDKSALSVLGVTHILNVAADLPNAFPSD--YVYCSVPMYDDEDEVLMQHYSKCQDFIDEALSKEDgRLLVHCRAGRSRSVSIAVAYMM
||.|.. |.. | .  .|. |.. ..|||. .|||.| ..    |  .|. |   . |.... .  .||||| ||.   .|||| || |||| ...||.|
lpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskks.kvlvhClaGisrsvtvtlaylm

HKdKSLTVEEALGKIRETRPNADPNAGFFKQLKALEIELQ
.| . |....|   ... ..|  ||  |..||.  | .|.
kk.lalslndaydlvkkrksnisPnfnfmgqlldferslr
0048076 (Phosphotyrosine protein) phosphatases II 77-213 1.5e-30 101.1 In-house 8-142 (145) alignment 
Range on Protein: 77-213
Range on HMM: 8-142/145.0
LPRLFIASQDVAYDKSALSVLGVTHILNVAADLPNAFPSDYVYCSVPMYDDEDEVLMQHYSKCQDFIDEALSKEdGRLLVHCRAGRSRSVSIAVAYMMHK
||.|.. |. .|.|   |  ||.|..||.. .|.. .. .. |. .|. | .   |...  .. .||.|||... |. ||||.||..|. ....||.|..
lpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll

DKsLTVEEALGKIRETRPNADPNAGFFKQLKALEIEL
 . ...|||| ..|. ||.| || |....|. .| ||
lg.vsleealelvrsqrpgavpnpgqlrflyefelel
subfamily_LRR-DSP_pd Subfamily LRR-DSP 77-215 1.8e-30 99.9 In-house 124-260 (263) alignment 
Range on Protein: 77-215
Range on HMM: 124-260/263.0
LPRLFIASQDVAYDKSALSVLGVTHILNVAADLPNAFPSDYVYCSVPMYDD-EDEVLMQHYSKCQDFIDEAlsKEDGRLLVHCRAGRSRSVSIAVAYMMH
...||. ..| | .|| |  |||||||   ||.   ||  . | |.   .| ..  . ||. .   ||.|   .. | .||||||| ||| .. ..|.|.
idklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeG..rkkGGvlvhcraGvsrsstlvisylmk

KdKSLTVEEALGKIRETRPNADPNAGFFKQLKALEIELQG
| ..|. .|||  . . ||.  || || .|||  | .|  
k.qrlkfkealdlvikkrpriqPnpGfkdqlkkyekklfc
PTPc_motif_SM00404 77-210 2e-30 100.5 In-house 6-138 (140) alignment 
Range on Protein: 77-210
Range on HMM: 6-138/140.0
LPRLFIASQDVAYDKSALSVLGVTHILNVAADLPN-AFPSDYVYCSVPMYDDEDEVLMQHYSKCQDFIDEAlSKEDGRLLVHCRAGRSRSVSIAVAYMMH
||.|...|.. | ..  |. ||.||..||.   ..    |.. ....|. |.| . | .. .|. |||..|  |. |. ||||.|| |||.....||.|.
lphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfiena.ekkggkvlVHCqaGvSRSatliiaYlmr

KdKSLTVEEALGKIRETRPNADPNAGFFKQLKALE
. ..|...||.  ..| ||. .||..|..||  .|
y.rqlslaeayefvkerRpiispnlnfvrqLieye
0048179 (Phosphotyrosine protein) phosphatases II 77-210 1.7e-28 94.5 In-house 8-141 (144) alignment 
Range on Protein: 77-210
Range on HMM: 8-141/144.0
LPRLFIASQDVAYDKSALSVLGVTHILNVAADLPNAFPSDY--VYCSVPMYDDEDEVLMQHYSKCQDFIDEALSkEDGRLLVHCRAGRSRSVSIAVAYMM
||.|.. |. .|.|   |  ||.|...|.. . ...|. ..   |. .|. | .   |...  .. .||.|||. |.|. ||||.||..|. ....||.|
lpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylm

HKDKsLTVEEALGKIRETRPNADPNAGFFKQLKALE
.| . |..||||  .|. ||.| || |....|. .|
kklg.lsleealalvrsrrpgavpnpgqlrfLleye
0049260 (Phosphotyrosine protein) phosphatases II 77-208 4.4e-26 86.8 In-house 12-144 (152) alignment 
Range on Protein: 77-208
Range on HMM: 12-144/152.0
LPRLFIASQDVAYDKSALSVLGVTHILNVAADLPNA---FPSDYVYCSVPMYDDEDEVLMQHYSKCQDFIDEALSKEDGRLLVHCRAGRSRSVSIAVAYM
.. ... ....| ..  |  ||.|.|...  .|...   ..  . |. .|. |.    | |.   . .||.... ...|. ||||.|| .|.  ...||.
iatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaayl

MHkdKSLTVEEALGKIRETRPNADPNAGFFKQLKA
|.  . ...|||.  .|| ||.| || |. ..|. 
ml..lgvsleeavalvrekRpgavpnpgqlrflye
0051082 (Phosphotyrosine protein) phosphatases II 77-209 1.8e-21 71.8 In-house 12-149 (151) alignment 
Range on Protein: 77-209
Range on HMM: 12-149/151.0
LPRLFIASQDVAYDKSALSVLGVTHILNVAADLPNAFPSDY------VYCSVPMYDDEDEVLMQHYSKCQDFIDEALSKEDGRLLVHCRAGRSRSVSIAV
 ..|.. ..  | .   |  ||...|.|.  . ....  .|       .. .|. |. |  | ...  ...|....|.|..| .||||.||..|.  ...
tgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlva

AYMMHkdKSLTVEEALGKIRETRP-NADPNAGFFKQLKAL
.|.|.    ...||||  .|..||    || .|..||.||
lylml..lgvsleealeeyrlkrpgvvqpnqqflfqlfal
subfamily_DSP14_pd Subfamily DSP14 78-216 4.7e-33 108.3 In-house 12-147 (157) alignment 
Range on Protein: 78-216
Range on HMM: 12-147/157.0
PRLFIAsQDVAYDKSALSVLGVTHILNVAADLPNAFPSDYVYCSVPMYDDEDEVLMQHYSKCQDFIDEaLSKEDGRLLVHCRAGRSRSVSIAVAYMMhKD
| ||..   .| .|..|.  ..|.|.||. .|||   .|  .  ||. |.... |..|. .  | |.| ..|..|. |||| ||.||| |...||.| | 
psLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkiee.vkkkggktlvhCvaGvSRSAslclaylm.ky

KSLTVEEALGKIRETRPNADPNAGFFKQLKALEIELQGT
..|. .||   ....||   || ||.||| ..| .|.|.
eklsLreayklvksaRpiirPNvGFwkqlidyEkklkgk
0043147 (Phosphotyrosine protein) phosphatases II 78-208 1.4e-26 88.7 In-house 24-155 (172) alignment 
Range on Protein: 78-208
Range on HMM: 24-155/172.0
PRLFIASQDVAYDKSALSVLGVTHILNVAAD---LPNAFPSDYVYCSVPMYDDEDEvLMQHYSKCQDFIDE-ALSKEDGRLLVHCRAGRSRSVSIAVAYM
. ..  . ..| .   |  ||.|||.|.       .. ..... |. .|..|     |...  .. .|||| .. ...|. ||||.|| .|.. ...||.
atqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaayl

MHkdKSLTVEEALGKIRETRPNADPNAGFFKQLKA
|.  ..|..|||.  .|| ||.| .| .. ..|. 
ml..lglsleeavalvrekRpgavqnpsqyrflyy
0041856 (Phosphotyrosine protein) phosphatases II 78-213 1.7e-24 81.8 In-house 24-172 (182) alignment 
Range on Protein: 78-213
Range on HMM: 24-172/182.0
PRLFIASQDV--------------AYDKSALSVLGVTHILNVAadLPNAFPSDY-----VYCSVPMYDDEDEVlmqhYSKCQDFIDEALSkEDGRLLVHC
..|.. |.                | .   |  ||.|.|.|..   .. .|...      |. .|. |..        ... |||.|.|. |.|. ||||
anlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd....ldelldfieevle.eggpvlVHC

RAGRSRSVSIAVAYMMHKDKsLTVEEALGKIRETRP--NADPNAGFFKQLKALEIEL
.||..|. ....||.|.| . ...|||.  .|. ||     || .|| ||..||. |
saGvgRtgtlvaaylmkklg.vsleeavklvrsrRpgmvitpnqyfflqlallelll
0037934 (Phosphotyrosine protein) phosphatases II 78-212 3.3e-22 74.7 In-house 44-240 (243) alignment 
Range on Protein: 78-212
Range on HMM: 44-240/243.0
PRLFIASQ--------DVAYDKSALSVLGVTHILNVAADL---------------------------------------------PNAFPSDYVYCSVPM
|||.. ..        |.| .   |  ||.|.|...  .                                              .. .  .. |. .|.
prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpw

YD----DEDEVLMQHYSKCQDFIDEA----LSKEDGRLLVHCRAGRSRSVSIAVAYMMHKDKSLTVEEALGKIRETRPN-ADPNAGFFKQLKALEIE
 |    |. | |... .....||.|.      ...|..||||.||..|.  ...||.|..  ....|||. ..|| ||. | .. .....|  ...|
pdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyealle
0036282 (Phosphotyrosine protein) phosphatases II 78-210 4.1e-21 70.9 In-house 17-166 (174) alignment 
Range on Protein: 78-210
Range on HMM: 17-166/174.0
PRLFIASQDVAyDKSALSVLGVTHILNVAADLPNA---------------FPSDYVYCSVPMYDDEDEVLMQhYSKCQDFIDEALSK-EDGRLLVHCRAG
|||.. .   | .   |  ||.|.....    ..                 .... |. .|. |..   | .   .. .|..||||. ..| .||||.||
prliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaG

RSRSVSIAVAYMMHKDKSLTVEEALGKIRETR---PNADPNAGFFKQLKALE
..|.  ...||.|.. .  ....||  .|| |   |.. .. .....|  .|
vgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfe
subfamily_Slingshot_pd Subfamily Slingshot 79-210 1.3e-29 96.7 In-house 25-154 (169) alignment 
Range on Protein: 79-210
Range on HMM: 25-154/169.0
RLFIASQDVAYDKSALSVLGVTHILNVAADLPNAFPSDYVYCSVPMYDDEDEVLMQHYSKCQDFIDEAlSKEDGRLLVHCRAGRSRSVSIAVAYMMhKDK
 ... |.  | .   |.  ||..||||. .. | || .. |. . .||.|.. |.... .  .||..|  |.. ..||||. | ||| |. .|| | |. 
hvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfieka.kkkgskvlvhckmGvsrsastviayam.key

SLTVEEALGKIRETRPNADPNAGFFKQLKALE
.|..||||  ..| |  . ||.||.|||.. |
glsleealeyvkerrsvikPnkgflkqleeye
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 79-213 5.7e-18 58.4 In-house 5-141 (145) alignment 
Range on Protein: 79-213
Range on HMM: 5-141/145.0
RLFIASQDVAYDKSALSVLGVTHILNVAADLPN----AFPSDYVYCSVPMYDDEDEVLMQHYSKCQDFIDEAlsKEDG-RLLVHCRAGRSRSVSIAVAYM
||.. |   | | ..|  ||.. |.|.||        .   ..    .   | |   | ||. .  ||||    ||.|  ..||| || ||||...||..
rlyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkg..keegagvfvhcmagvsrsvtvsvafl

MhKDKSLTVEEALGKIRETRPNADPNAGFFKQLKALEIEL
| |  ..|. ||  ..|  |  | ||  |.|.|  || .|
m.kycnmtlseaarqvrsnrllaypnvtflknllnlekql
subfamily_STYXL1_pd Subfamily STYXL1 79-214 9.2e-17 54.7 In-house 18-154 (157) alignment 
Range on Protein: 79-214
Range on HMM: 18-154/157.0
RLFIASQDVAYDKSALSVLGVTHILNVAAD---LPNAFPSDYVYCSVPMYDDEDEVLMQHYSKCQDFIDEALSkEDGRLLVHCRAGRSRSVSIAVAYMMH
.|..     |....    | |   .||. |   | .. .       ... |...  |... ..  .||..    |.  .||    | |||.....||.|.
klylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkk.egevvlvfsnkGisrsaaviiaylmy

KDKsLTVEEALGKIRETRPNADPNAGFFKQLKALEIELQ
. | .| ..|. .... ..|  || .| .||.  | .| 
skk.itlkkaykylkkCkenvkPnrafveqlseWekqll
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 80-213 3.9e-31 101.5 In-house 10-152 (154) alignment 
Range on Protein: 80-213
Range on HMM: 10-152/154.0
LFIASQDVAYDKSALSVLGVTHILNVAADLPNAFPSD---------YVYCSVPMYDDEDEVLMQHYSKCQDFIDEAL-SKEDGRLLVHCRAGRSRSVSIA
|.|.|.| |..|  |    ...||||.   .|.|. .         . |. . ..|| .  ......|. .|||.|. . |....|||. .| ||| ...
lyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaall

VAYMMHKdKSLTVEEALGKIRETRPNADPNAGFFKQLKALEIEL
..|.|.| ..... .||  ....|.   || || |||.  | ||
isylmdk.lkislslalellkdsryiikPnqGflkqleifekel
DSPc Dual specificity phosphatase, catalytic domain 80-210 2.2e-28 93.8 Pfam-A 1-131 (133) alignment 
Range on Protein: 80-210
Range on HMM: 1-131/133.0
LFIASQDVAYdKSALSVLGVTHILNVAADLPN---AFPSDYVYCSVPMYDDEDEVLMQHYSKCQDFIDEAlSKEDGRLLVHCRAGRSRSVSIAVAYMMHK
|...|.  |  .. |. ||.|...||.   ||     .|.. | ..|. |.... . .. ... .||..|  .. .. ||||.|| ||| ....||.| .
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefieka.eqkgkkvlVHCqaGisRSatliiaYlmkt

DKSlTVEEALGKIRETRPNADPNAGFFKQLKALE
..  ...||.  ..| |..  ||||| .|| ..|
knl.slneAyefvkerrskispnagflrqLleye
DSPc Dual specificity phosphatase, catalytic domain 80-210 2.2e-28 93.8 In-house 1-131 (133) alignment 
Range on Protein: 80-210
Range on HMM: 1-131/133.0
LFIASQDVAYdKSALSVLGVTHILNVAADLPN---AFPSDYVYCSVPMYDDEDEVLMQHYSKCQDFIDEAlSKEDGRLLVHCRAGRSRSVSIAVAYMMHK
|...|.  |  .. |. ||.|...||.   ||     .|.. | ..|. |.... . .. ... .||..|  .. .. ||||.|| ||| ....||.| .
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefieka.eqkgkkvlVHCqaGisRSatliiaYlmkt

DKSlTVEEALGKIRETRPNADPNAGFFKQLKALE
..  ...||.  ..| |..  ||||| .|| ..|
knl.slneAyefvkerrskispnagflrqLleye
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 80-210 6.3e-28 91.1 In-house 15-144 (148) alignment 
Range on Protein: 80-210
Range on HMM: 15-144/148.0
LFIASQDVAYDKSALSVLGVTHILNVAADLPNAFPSDYV-YCSVPMYDDEDEVLMQHYSKCQDFIDEAlSKEDGRLLVHCRAGRSRSVSIAVAYMMHKdK
||. |.  | | .||  ||||.| | ... .||.    . |  |.. |...| | . . .  .|...|  .| .| |||.. |.|||  .|......  |
LFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrka.kdeGrrvLvhlqmGvsrssalallwlidf.k

SLTVEEALGKIRETRPNADPNAGFFKQLKALE
  ...|||  ... |.  ||| || |||  ||
rvslkealalvkskrryvdpnlgfLkqLaele
subfamily_MKPLT_pd Subfamily MKPLT 80-210 8e-26 84.5 In-house 29-157 (164) alignment 
Range on Protein: 80-210
Range on HMM: 29-157/164.0
LFIASQDVAYDKSALSVLGVTHILNVAADLPNAFPSDYVYCSVPMYDDEDEVLMQHYSKCQDFIDEALSkEDGRLLVHCRAGRSRSVSIAVAYMMHKDKS
|.    . | ..  |  | .|||.||. .  .|||   .|  | . |  || |...  . ..|. .|.    ||.||||  |.||| |..||....  . 
lylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaid.sGGrvlvhcvqGksrsssvtvafLikskgw

lTVEEALGKIRETRPNADPNAGFFKQLKALE
 |..||   ..| |  . || ||.|||   |
.tlkeayeylkerrsivapnrGflkqlakfe
subfamily_MKPLV_pd Subfamily MKPLV 80-210 8e-26 84.5 In-house 29-157 (164) alignment 
Range on Protein: 80-210
Range on HMM: 29-157/164.0
LFIASQDVAYDKSALSVLGVTHILNVAADLPNAFPSDYVYCSVPMYDDEDEVLMQHYSKCQDFIDEALSkEDGRLLVHCRAGRSRSVSIAVAYMMHKDKS
|.    . | ..  |  | .|||.||. .  .|||   .|  | . |  || |...  . ..|. .|.    ||.||||  |.||| |..||....  . 
lylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaid.sGGrvlvhcvqGksrsssvtvafLikskgw

lTVEEALGKIRETRPNADPNAGFFKQLKALE
 |..||   ..| |  . || ||.|||   |
.tlkeayeylkerrsivapnrGflkqlakfe
0046846 (Phosphotyrosine protein) phosphatases II 85-214 3.8e-24 80.8 In-house 29-173 (176) alignment 
Range on Protein: 85-214
Range on HMM: 29-173/176.0
Q-----DVAYDKSALSVLGVTHILNVAADL-----------PNAFPSDYVYCSVPMYDDEDEVLmQHYSKCQDFIDEALSKEdGRLLVHCRAGRSRSVSI
|     ..| .   |  ||.|...|.  .            |     .. |. .|. |     | ..  .. .||.|||..  |. ||||.||..|.  .
qgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtl

AVAYMMHKDKSLTVEEALGKIRETRP-NADPNAGFFKQLKALEIELQ
..||.....| |.||||| ..|| || .| .. .. ..|.  | .|.
vaayllelekglsveealalvreqRplgavqtpeQyrflyefellll
0040439 (Phosphotyrosine protein) phosphatases II 86-213 3e-21 71.6 In-house 66-245 (249) alignment 
Range on Protein: 86-213
Range on HMM: 66-245/249.0
DVAYDKSALSVLGVTHILNVAADLPN-------------------------------------------AFPSDYVYCSVPMYDDEDEVLMQHYSKCQDF
 |. .   |  ||.|.|...  . ..                                            ..... .  ....|  |  . .. . . ||
tvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldf

IDEALS-----KEDGRLLVHCRAGRSRSVSIAVAYMMH----KDKSLTVEEALGKIRETRPNADPNAGFFKQLKALEIEL
|.....     ...|..|||| || .|.  ...||.|.    | . ...|||. ..|. ||.| .| .....|  ...||
ieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
0042113 (Phosphotyrosine protein) phosphatases II 93-212 8.8e-19 63.3 In-house 71-241 (245) alignment 
Range on Protein: 93-212
Range on HMM: 71-241/245.0
ALSVLGVTHILNVAADLP----------------------------------------------NAFPSDYVYCSVPMYDDEDEVLMQHYSKCQDFIDEA
 |  ||.|.|...  . .                                              .    ...|. .|. |.    |...  .. .|...|
mlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrka

LS-KEDGRLLVHCRAGRSRSVSIAVAYMMH----KDKSLTVEEALGKIRETRPNADPNAGFFKQLKALEIE
|. ...|..||||.||..|.  ...||.|.    | . ...|||. ..|. ||.| .. .....|  ...|
laedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
0045450 (Phosphotyrosine protein) phosphatases II 97-213 1.6e-19 66.3 In-house 130-303 (307) alignment 
Range on Protein: 97-213
Range on HMM: 130-303/307.0
LGVTHILNVAADLPNAF----------------------------PSDYVYCSVPMYDD-----------------EDEVLMQHYSKCQDFIDEALS---
.|||.|...  . ....                             ..|..  ... |                   |  . .. . . |||.|...   
qgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkale

--KEDGRLLVHCRAGRSRSVSIAVAYMMHKDKS-------LTVEEALGKIRETRPNADPNAGFFKQLKALEIEL
  ...|. ||||.|| .|. ....||.| .          ....||. ..|| ||.| .| .....|  ...||
elpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
0040438 (Phosphotyrosine protein) phosphatases II 97-212 1.1e-18 63.0 In-house 109-274 (317) alignment 
Range on Protein: 97-212
Range on HMM: 109-274/317.0
LGVTHILNVAADLPNA---------------------------FPSDYVYCSVPMYDD----------------EDEVLMQHYSKCQDFIDEALSK---E
.|||.|...    ..                              .....  ....|.                 |  . .. . ..||.... ..   .
qgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedp

DGRLLVHCRAGRSRSVSIAVAYMMH----KDKSLTVEEALGKIRETRPNADPNAGFFKQLKALEIE
.| .|||| || .|. ....||.|.    | . ..||||. ..|| ||.| .. .....|  ...|
ggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalle
0039614 (Phosphotyrosine protein) phosphatases II 98-213 3.4e-17 58.3 In-house 125-288 (297) alignment 
Range on Protein: 98-213
Range on HMM: 125-288/297.0
GVTHILNVAADLPNAF-------------------------PSDYV-----------------YCSVPMYDDEDEVLMQHYSKCQDFIDEALSK--EDGR
|||.|...    ..                            ..|.                 .. ... |.    ....  .  ....|||..  ..|.
gvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggp

LLVHCRAGRSRSVSIAVAYMMH----KDKSLTVEEALGKIRETRPNADPNAGFFKQLKALEIEL
 |||| || .|. ....||.|.    | . ..|.||. ..|| ||.| .. .....|  ...||
vlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel
0036941 (Phosphotyrosine protein) phosphatases II 98-213 6.5e-16 53.9 In-house 102-276 (297) alignment 
Range on Protein: 98-213
Range on HMM: 102-276/297.0
GVTHILNVAADLPNAF-------------------------------PSDYVYCSVPMYD----------------DEDEVLMQHYSKCQDFIDEALS--
.||.|...  . .. .                                .||..  . ..|                  |  . .... . |||.....  
nvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl

---KEDGRLLVHCRAGRSRSVSIAVAYMM----H---KDKSLTVEEALGKIRETRPNADPNAGFFKQLKALEIEL
    ..|. ||||.|| .|| ....|..|    .   | . ... ||. |.|| ||.| .. .....|  ...||
kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallel
0049772 (Phosphotyrosine protein) phosphatases II 110-213 1.6e-26 89.2 In-house 173-273 (314) alignment 
Range on Protein: 110-213
Range on HMM: 173-273/314.0
PNAFPSD-YVYCSVPMYDdEDEVLMQHYSKCQDFIDEAlsKEDGRLLVHCRAGRSRSVS-IAVAYMMHKDkSLTVEEALGKIRETRPnADPNAGFFKQLK
|. |.   . |. .|..| ... | ... .. .||.||  ...|..||||.||..|. . ...||.|..   ...||||  .|..|| . || ||..||.
pelferlgikylripvpD.gsaplledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll.gvsleealedvrlkRp.inpnpgfieqle

ALEIEL
 .| .|
qyefil
subfamily_PTEN_pd Subfamily PTEN 113-194 3.6e-07 25.3 In-house 73-157 (184) alignment 
Range on Protein: 113-194
Range on HMM: 73-157/184.0
FPSDYVYCSVPMYDDEDE--VLMQHYSKCQDFIDEALSKEDGRL-LVHCRAGRSRSVSIAVAYMMHKDKSLTVEEALGKIRETRP
. |. . . |..|. .|.    ..  ... . |.. |.... ..  |||.||. |.  . |||.... .  . ||||    |.| 
ydskkfdgrvavypfdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRt
0038934 (Phosphotyrosine protein) phosphatases II 116-208 2.3e-16 55.5 In-house 79-171 (194) alignment 
Range on Protein: 116-208
Range on HMM: 79-171/194.0
DYVYCSVPMYDD----EDEVLMQHYSKCQDFIDEalsKEDGRLLVHCRAGRSRSVSIAVAYMMHKDKSlTVEEALGKIRETRPNADPNAGFFKQLKA
.. | . |. ||     .|.|.. .. ...|..|   ...|  .||| ||..|.  ...||.... .  ..|||.. .|| ||.| || .....|  
gieylklpfpddgtvPsleillrfldlvdeflne...dpggvvaVHCkaGlgRtGtlvaaYLiyrlgm.saeeAialfrekRpgaipnqdyleallk
0043336 (Phosphotyrosine protein) phosphatases II 116-212 6.2e-15 50.9 In-house 177-275 (278) alignment 
Range on Protein: 116-212
Range on HMM: 177-275/278.0
DYVYCSVPmyDDEDEVLMQHYSKCQDFIDEALSKEDGRLLVHCRAGRSRSVSIAVAYMMH----KDKSLTVEEALGKIRETRPNADPNAGFFKQLKALEI
 | | ..|  |..    .... .   ...|||....| .||||.|| .|.  ....|...    | . ...|||. ..|| ||.| ..  ....|  ...
hyhylgwp..dhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall

E
|
e
subfamily_PTPMT1_pd Subfamily PTPMT1 121-199 7.5e-13 43.3 In-house 78-154 (171) alignment 
Range on Protein: 121-199
Range on HMM: 78-154/171.0
SVPMYDDEDEVLMQHYSKCQDFIDEALSKEDgRLLVHCRAGRSRSVSIAVAYMMHKdKSLTVEEALGKIRETRPNADPN
.... |  ... ... .|  .||..  || . |. |||.|||.|| ... .|.|.| . |. ||||  ... |.    .
qlatvDfteapdleklekgvefiekvaskgk.rvYvHCkaGrgRsatlvacylmkk.eklspeeAlkalkkkRkiirla
subfamily_MSG5_pd Subfamily MSG5 128-214 9.5e-11 35.1 In-house 77-161 (165) alignment 
Range on Protein: 128-214
Range on HMM: 77-161/165.0
EDEVLMQHYSKCQDFIDEALSKEDgRLLVHCRAGRSRSVSIAVAYMMhKDKSLTVEEALGKIRETRPNADPNAGFFKQLKALEIELQ
 |  ...  |.    |  | ||.. ..||||. | ||| |. |||.| |  .|....|  |..    . .|. |.  ||   |. |.
hdskivkdlsrltriihaatskrk.kilvhcqcglsrsaslivayim.kyynlslrdaydklksvaddispsiglifqlmewevals
0048567 (Phosphotyrosine protein) phosphatases II 128-196 8.6e-08 26.7 In-house 37-121 (157) alignment 
Range on Protein: 128-196
Range on HMM: 37-121/157.0
EDevlMQHYSKCQDF-----------------IDEALSKEDGRLLVHCRAGR---SRSVSIAVAYMMHKDKsLTVEEALGKIRETRPNA
..   ..... ..||                 . . |....... ||| ||.   .|.. .. .|.. . . .| |||.. .|  ||. 
dg...lvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlg.ftpeeaiaplrivrpgs
PTPc_DSPc_SM00012 134-196 4.8e-07 25.3 In-house 24-89 (105) alignment 
Range on Protein: 134-196
Range on HMM: 24-89/105.0
QHYSKCQDFIDEALSkeDGRLLVHCRAGRSRSVSIAVAYMMHKD-----KSLTVEEALGKIRETRPNA
..  .....  .. |   . ..|||.|| .|.  ..........     |.. ... . ..|. ||..
ellravkknknkses..skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgm
0047943 (Phosphotyrosine protein) phosphatases II 135-206 5.2e-13 44.5 In-house 187-264 (273) alignment 
Range on Protein: 135-206
Range on HMM: 187-264/273.0
HYSKCQDFIDEALSK--EDGRLLVHCRAGRSRSVSIAVAYMMH----KDKSLTVEEALGKIRETRPNADPNAGFFKQL
.  .. .....||..  ..|  .|||.|| .|. .........    | . ..|.||. ..|. ||.. ..  ....|
sllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
0046845 (Phosphotyrosine protein) phosphatases II 135-199 2.6e-09 32.4 In-house 190-259 (284) alignment 
Range on Protein: 135-199
Range on HMM: 190-259/284.0
HYSKCQDFIDEalSKEDGRLLVHCRAGRSRSVSIAVAYMMHKD----K---SLTVEEALGKIRETRPNADPN
 . ........  .. .|  .|||.|| .|.  .........     .    ..|.||. ..|| ||..  .
flrlvrellen..lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqt
Y_phosphatase Protein-tyrosine phosphatase 136-196 7.7e-06 20.8 Pfam-A 152-219 (235) alignment 
Range on Protein: 136-196
Range on HMM: 152-219/235.0
YSKCQDFIDEALSKE---DGRLLVHCRAGRSRSVSIAV-AYMMHKD---KSLTVEEALGKIRETRPNA
...  |.|..  ...   .| ..||| || .|. ....  .....    ... | ... ..|. ||..
pkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgm
Y_phosphatase Protein-tyrosine phosphatase 136-196 7.7e-06 20.8 In-house 152-219 (235) alignment 
Range on Protein: 136-196
Range on HMM: 152-219/235.0
YSKCQDFIDEALSKE---DGRLLVHCRAGRSRSVSIAV-AYMMHKD---KSLTVEEALGKIRETRPNA
...  |.|..  ...   .| ..||| || .|. ....  .....    ... | ... ..|. ||..
pkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgm
0050432 (Phosphotyrosine protein) phosphatases II 138-200 4.3e-11 38.2 In-house 218-285 (308) alignment 
Range on Protein: 138-200
Range on HMM: 218-285/308.0
KCQDFIDEALSK-EDGRLLVHCRAGRSRSVSIAVAYMM----HKDKSLTVEEALGKIRETRPNADPNA
 . ||.... .. ..|  .|||.|| .|.  .......    .|.. ..|.||. |.|| ||.. .. 
illdflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp
0051299 (Phosphotyrosine protein) phosphatases II 140-200 2.7e-11 39.0 In-house 208-272 (288) alignment 
Range on Protein: 140-200
Range on HMM: 208-272/288.0
QDFIDEALSKEDGRLLVHCRAGRSRSVSIAVAYMM----HKDKSLTVEEALGKIRETRPNADPNA
  ....||.. .|  .|||.|| .|.  .......    .| . ..|.||. ..|| ||.. .. 
lrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp
subfamily_PTPDC1_pd Subfamily PTPDC1 141-196 2.5e-08 28.6 In-house 106-158 (182) alignment 
Range on Protein: 141-196
Range on HMM: 106-158/182.0
DFIDEALSKEdgRLLVHCRAGRSRSVSIAVAYMMHKDKsLTVEEALGKIRETRPNA
  .. ||...  .. ||| ||. |   .  .|...... || |.|. ..|. ||..
kvvafalqeg..kvavhChaGlGrtGvliacylvyakr.ltaekaiklvrskrpks
subfamily_CDC14_pd Subfamily CDC14 146-195 8.2e-07 23.2 In-house 258-306 (328) alignment 
Range on Protein: 146-195
Range on HMM: 258-306/328.0
ALSKEDGRLLVHCRAGRSRSVSIAVAYMMhKDKSLTVEEALGKIRETRPN
.. | .| . |||.||  |  ..  .|.| |.  .| .||.. .| .|| 
iaekaeGaiavhCkaGLGrtGtLiacylm.khyrftaaeaiawlricrPG