Gene MTMR10-2 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR10
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP027_AA protein Get Run
AqueP027_AA_573-1045 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Death Death domain 26-101 3.5e-10 27.6 Pfam-A 11-81 (83) alignment 
Range on Protein: 26-101
Range on HMM: 11-81/83.0
TTSDWRKFGSVAGLKYNTLNNIQENKTKVEDRFEECLACWLRRkddvdSKGKPSWRRLVEILEELGERALADKISN
...||.....  ||.......|... ......  | |  |  |      . . . ..|.|.|..|| | .|.|. .
lgkdWkeLarkLglsedeideiesenprlreqtyelLqlWeqr.....egknatlgaLleaLrklgrrdaaekles
GRAM GRAM domain 431-466 9.4e-06 16.5 Pfam-A 28-53 (69) alignment 
Range on Protein: 431-466
Range on HMM: 28-53/69.0
GYIYGTLYITNHRLSFKPAPFNTDKlspldrssvvK
|  .|.||.||.|| |.. .. . |           
gpvqGrlYlTnyrliFrSdklddsk..........v
Myotub-related Myotubularin-like phosphatase domain 543-655 3.6e-23 74.9 Pfam-A 2-103 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 543-655 3.6e-23 74.9 In-house 2-103 (353) alignment
subfamily_MTMR10_pd Subfamily MTMR10 544-668 1.4e-27 88.5 In-house 174-311 (380) alignment 
Range on Protein: 544-668
Range on HMM: 174-311/380.0
FAFDYARVVHKTKDTHSSSSSSSQDVI------------PTYFNPRDWQKELDRLGVNQKQWRVTEANQHFLLCDSLPPYIVVPYNISDDTLE-YAAGLH
.|.|....|...|.......|...|..            |.|.. ...|..... .|..............  ..|..|.........|..|| ... ..
tasdavktvvekkrsvilqesegrDlscvvaSLaqlmldphyrtisGfqsliqkewvaaghpfldrlghikpseksespvfllFldcvdqlleqfpseFe

FKNRLPVWCWSHSVTGVSLTRGSLPDEDRLEAPDPSYM
|........|..|..|. ||. .  .| ||.| . | .
FtetfLialwdsshsgifltflfnseeqrlkavvsssp
0040695 (Phosphotyrosine protein) phosphatases II 572-1043 5.1e-79 259.7 In-house 6-387 (388) alignment 
Range on Protein: 572-1043
Range on HMM: 6-387/388.0
TYFNPRDWQKELDRLGVNQKQWRVTEANQHFLLCDSLPPYIVVPYNISDDTLEYAAGLHFKNRLPVWCWSHSVTGVSLTRGS------------------
 . . .|. .|| |||.. . ||..  |... ||.|.|...|||. |||..|...|    |.|.||....|. .| .|.| |                  
egwslydilrelkrlglgldlwrisivNenyelcpsYPallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplvglllsrsledekll

------LPDEDRLEAPDPSYMYAVAMARNLEVQVEN-KLVRQYRVQEYVAATAREIQTAYSKLMEVCtISTCHDLaradqKWLATLDSSHWLHYVKSCLS
      ||. ..|   |   .. . ..| |. .||| .. ...... .     . .. .. ||...| .... .|     ..|  |..|.||...|..|.
eailkllpnlskllivdlrpklnalanralgggvenedaypnaeliflnipnihvvreslqklldac.lnvpdsl.....nllslleesgwldliklile

LASDIVKTLCEKRTSCVLLDQNDRDLACVISSLVQIMADPHYRTISGFESLVQKEWVAMGHPFTTRSGLITDAPsneelVPDGQAPVFVLFCDCVWQLTV
||  ||| |  . .|... . ...|. ...|||.|.. ||.|||. || .|..|||...||.| .|.|.  .        ... .|||.|| ||||||. 
lavlivklldlgnssvlvhcsdgwdrtsqlssLaqllldPyYRTleGFqvLiekeWlsfghkfadRlghlesei.....dskefsPvFllFLdcvwqLlr

QFPSAFQFTPSFLVKFVSLTASSIYSNFVFDSAKARVEASNHSKRSSYyvsqlvdlqsshsdaekyegplvsawgkWRSSLT---AeetenWLNPFYYIF
|||.||.|.. .|. ..  . |.....|.|.| | |.|.| .....|                             |.  |          .|||.|  .
qfPtaFeFnerlLlfLadhlyscrfgtFlfnsekerlelsvsertlsl............................wsyllsrkse.....flnplYdps

GsgdahneftftgnllpfessvfnllfsdmlpdktsggnfglysdqplplplssheltperaeqvslhsisssspSPLLLPNTAMPSLVFWADYFFRFIP
                                                                           . .|||.. ...|..| .|..|..|
s..........................................................................levllpslsvldlllWleyylrwlp
subfamily_MTMR9_pd Subfamily MTMR9 572-655 1e-14 46.4 In-house 13-96 (393) alignment 
Range on Protein: 572-655
Range on HMM: 13-96/393.0
TYFNPRDWQKELDRLGVNQKQWRVTEANQHFLLCDSLPPYIVVPYNISDDTLEYAAGLHFKNRLPVWCWSHSVTGVSLTRGSLP
. ..  | ..|. .| . ...||... |..| .| | |. ..|| .|.|..|.  |    . |.|| .. |. |.  | | | |
dgysafdrenefaklisasdewRissvNknfkvcasypesvivPkaiddeelkasaafreggrfPvLsylhketkavllrssqp
subfamily_MTMR6_pd Subfamily MTMR6 574-655 2.1e-11 35.8 In-house 19-100 (397) alignment 
Range on Protein: 574-655
Range on HMM: 19-100/397.0
FNPRDWQKELDRLGVNQKQWRVTEANQHFLLCDSLPPYIVVPYNISDDTLEYAAGLHFKNRLPVWCWSHSVTGVSLTRGSLP
..  |...|. |.|| ...| .|..|... |||. |  ..|| ... ..|  .. .  |.||||  . |  .  .. | | |
wklldlkaeytrmgvpnekwtltdlnkdyelcdtyprelyvPksatkevlvgsskfrskgrlPvlsylhkeneaaicrcsqp
subfamily_MTMR3_pd Subfamily MTMR3 576-656 1.1e-15 50.4 In-house 26-107 (442) alignment 
Range on Protein: 576-656
Range on HMM: 26-107/442.0
PRDWQKELDRLGVN-QKQWRVTEANQHFLLCDSLPPYIVVPYNISDDTLEYAAGLHFKNRLPVWCWSHSVTGVSLTRGSLPD
  . ..|..||| . ...||....|..| || | |  ..||  |.||.|. .|     .|||.  | |  .|  |.| | |.
eeklkeeverlGfdlkeawrisdvnsdfklCssyPkklivPksitdddlkkvasfrslkrlPavvwrhkkngavlarcsqPe
subfamily_MTMR1_pd Subfamily MTMR1 578-893 1.6e-63 207.3 In-house 11-341 (389) alignment 
Range on Protein: 578-893
Range on HMM: 11-341/389.0
DWQKELDRLGVNQK-QWRVTEANQHFLLCDSLPPYIVVPYNISDDTLEYAAGLHFKNRLPVWCWSHSVTGVSLTRGSLPD---EDRLEAPDPSYMYAVAM
| ..||.|||. .. .||.|. |... |||. |. .||| ..||..|. .| .. |.|||| .| .  .. ...| | |    ... .. |  |. |.  
dpeaelerlgllneklWritklnkkyelcdtYpavlvvpkvvsdedlkkvaafrskgRlPvlswlnkenqavilrasqplvGlsgkrskedekylqaile

ARN--LEVQVENKLVRQYRVQEYVAATAREIQTAYSKL----MEVCTISTC-------HDLAR---ADQKWLATLDSSHWLHYVKSCLSLASDIVKTLCE
| .   .. . ..  .   |.. . .   | ..|| .     ... .| .        ..|.     |.|||..|.|..||...|. |. |  ||... .
anaqsekllildarssvnavankakgkgyeseeaYknaelifldihnihvvReslkklkelvlpnvddkkwlsalestkWlehiklilagavkivekvet

KRTSCVLLDQNDRDLACVISSLVQIMADPHYRTISGFESLVQKEWVAMGHPFTTRSGLitdapSNEELVPDGQAPVFVLFCDCVWQLTVQFPSAFQFTPS
..|| ..  ..  |    . || ... |..||||.||| |..|||...||.|..| |      ....  .. ..|||. |.||||||| |||.||.|. .
ektsvlvhcsdGWDRtaqltsLamlllDsyyRtieGfevliekeWlsfGHkfkeRlgh.....gdknssdaersPvFlqfiDcvwqltrqfptAFefnee

FLVKFVSLTASSIYSNFVFDSAKARVEASNHSKRSS
||. ..    |... .|.|.| |.||... ..|  |
fLitlldhlysclfGtflfnsekervkekvkektvs
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 578-655 2.7e-18 58.3 In-house 20-98 (404) alignment 
Range on Protein: 578-655
Range on HMM: 20-98/404.0
DWQKELDRLGVNQK-QWRVTEANQHFLLCDSLPPYIVVPYNISDDTLEYAAGLHFKNRLPVWCWSHSVTGVSLTRGSLP
| ..|  |||.... .||....|... ||.. | ..||| .|||. |. .|    |.|.|| .| |  .....|| | |
daeeEykRlgikseseWriskinsdyelcetYPkllvvPesisDeelkkvasfRskgRiPvlswrhrsknstitRssqp
subfamily_MTMR5_pd Subfamily MTMR5 581-654 4.3e-16 50.8 In-house 12-92 (483) alignment 
Range on Protein: 581-654
Range on HMM: 12-92/483.0
KELDRLGVN-------QKQWRVTEANQHFLLCDSLPPYIVVPYNISDDTLEYAAGLHFKNRLPVWCWSHSVTGVSLTRGSL
.. .|||..       ....|..|.|... .|.| |  |||| ..|||...  |  . .||||| .| |. ..  | |.. 
qdykRlGlgalngaskrgkfrisevNkkytvcrsYPalivvPsevsddsiarvakcfrqnRlPvvtWrhernkalLiRsgg
subfamily_pats1_pd Subfamily pats1 581-650 1.4e-07 22.3 In-house 13-81 (691) alignment 
Range on Protein: 581-650
Range on HMM: 13-81/691.0
KELDRLGVNQKQ-WRVTEANQHFlLCDSLPPYIVVPYNISDDTLEYAAgLHFKNRLPVWCWSHSVTGVSLT
.| .||...  . |||.|  ..  |..  |. |.||  .||. |   .  . . ..|| .||.     || 
iegqrlkldldkdwrvveflsrd.lseiyPkrilvPklvsdellvsyv.rkrsskiPvlswsnqnnksslf
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 589-655 2.2e-06 18.7 In-house 38-104 (405) alignment 
Range on Protein: 589-655
Range on HMM: 38-104/405.0
NQKQWRVTEANQHFLLCDSLPPYIVVPYNISDDTLEYAAGLHFKNRLPVWCWSHSVTGVSLTRGSLP
..  |.||. |... .| | .  .||  .  |  ||    .. | |.|   |    .  |..| | |
sncywkvtsinkeykmcssyssslvvlskaldkdlekifsfrskgripslswkdpssnasisrcsqp
subfamily_MTMR9_pd Subfamily MTMR9 672-895 1.8e-47 154.3 In-house 136-349 (393) alignment 
Range on Protein: 672-895
Range on HMM: 136-349/393.0
AMARNLEVQVENKLVRQYRVQEYVaATAREIQTAYSKLMEVCTistchDLARADQKWLATLDSSHWLHYVKSCLSLASDIVKTLCEKRTSCVLLDQNDRD
|.... ....|.| .   .... . .  ..|| ...||.|.|.     |.    .|.|  |..| ||. |.  |..|  ....| |. .. |. ...  |
arskgggietevkysqwkkasrsl.esvasiqdslaklleacs.....daglstdkflsrleksgwlsqvadlleaalvvaqcldeegapvvvhgeeGlD

LACVISSLVQIMADPHYRTISGFESLVQKEWVAMGHPFTTRSGLITDAPSNEELvpdgQAPVFVLFCDCVWQLTVQFPSAFQFTPSFLVKFVSLTASSIY
 .....||.|.. ||..||. |||.|...||.  ||||..|   .. .. ...|    ..|||.|| |||.|.  ||| .| |  ..|. .   . || .
atlqvtsLaqlildpdaRtvrgfealiereWiqaGHPFasRaskvaaketkkkl....sgpvfllFLDcvyqilsqfpasFEFneelLillfehsyssqf

SNFVFDSAKARVEASNHSKRSSYY
..|. |... | |.  ..|  | .
gtflcdneaerkelklkkktvslw
Myotub-related Myotubularin-like phosphatase domain 685-884 9.9e-54 175.4 Pfam-A 161-352 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 685-884 9.9e-54 175.4 In-house 161-352 (353) alignment
subfamily_MTMR10_pd Subfamily MTMR10 686-1043 1e-84 276.6 In-house 113-379 (380) alignment 
Range on Protein: 686-1043
Range on HMM: 113-379/380.0
VRQYRVQEYVAATAREIQTAYSKLMEVCTISTCHDLARADQKWLATLDSSHWLHYVKSCLSLASDIVKTLCEKRTSCVLLDQNDRDLACVISSLVQIMAD
. ... ... ... ...|.||.||.|.|.|.|.......|.|||..|....||.||. |||.|||.|||..||..|..| ....|||.||..||.|.|.|
dvklvdlsdelpsiqdvqkaylklreLcvidtseefvtlddkwlssLektrWLayvrlclstasdavktvvekkrsvilqesegrDlscvvaSLaqlmld

PHYRTISGFESLVQKEWVAMGHPFTTRSGLITDAPSNEElvpdgqaPVFVLFCDCVWQLTVQFPSAFQFTPSFLVKFVSLTASSIYSNFVFDSAKARVEA
|||||||||.||.||||||.||||..| | |......|.       |||.||.|||.||. ||||.|.||..||........|.|...|.|.|...|..|
phyrtisGfqsliqkewvaaghpfldrlghikpsekses.......pvfllFldcvdqlleqfpseFeFtetfLialwdsshsgifltflfnseeqrlka

SNHSKRSSYYVSQLVDlQSSHSDAEKYEGPLVSawGKWRSSLTAEETENWLNPfyyifgsgdahneftftgnllpfessvfnllfsdmlpdktsggnfgl
...|.     .|.|   ...  |   |. .|    .. .|      ....|.                                                
vvsssplliakselke.ndllkdeldyrqglya..eiiksirrlaaaksylrs...............................................

ysdqplplplssheltperaeqvslhsisssspsPLLLPNTAMPSLVFWADYFFRFIP
                                   .. | . .| .  | . ..|..|
..................................eiirPllqipdiqlWdeCYlRWvP
subfamily_MTMR5_pd Subfamily MTMR5 696-887 7.2e-42 135.8 In-house 235-419 (483) alignment 
Range on Protein: 696-887
Range on HMM: 235-419/483.0
AATAREIQTAYSKLMEVCTISTCHDlARADQKWLATLDSSHWLHYVKSCLSLASDIVKtLCEKRTSCVLLD-QNDRDLACVISSLVQIMADPHYRTISGF
   .|...... ||. .|. ||  .  .  | .| ... | ||. ..| | |.. .|. | . . | ||.   . .|.   .|||.|.. ||.|||. ||
lveirqvkasfkkllraClpstave.eaesqsFlksvedseWlqqissllqlsgavvd.lldlqgssvlvslEdGwdvtaqvsslaqllldpyYRtleGF

ESLVQKEWVAMGHPFTTRSGLITDAPSNeelvpdGQAPVFVLFCDCVWQLTVQFPSAFQFTPSFLVKFVSLTASSIYSNFVFDSAKARVEASN
. ||.|||.|.|| || || ... | |       | ||||. | |||.|.. ||| || |   .|  .     |  .  |..|| . |.|.. 
kvLveKEWLafGHrFtkrsnqtlsaqss......gfaPvFlqFLDcvhqvsrqfPlafefndfylkflayhsvsnrfrtfllDseyerlesgl
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 699-896 2.2e-44 144.2 In-house 167-353 (404) alignment 
Range on Protein: 699-896
Range on HMM: 167-353/404.0
AREIQTAYSKLMEVCtistcHDLARADQKWLATLDSSHWLHYVKSCLSLASDIVKTLCEKRTSCVLLDQNDRDLACVISSLVQIMADPHYRTISGFESLV
  |.. .. || ...     ..  . ...||  |.||.||  .|. |. . .||... ....|...   .  |  . .|||.|...||.||||.||..|.
ihelreslkklkkav.....nsiiekeknwlselessrWldhiklllegskriveliekekssvlvhcsdgwDrtsqlsslsqllldpyyrtiegFivli

QKEWVAMGHPFTTRSGLitdapsNEELVPDGQAPVFVLFCDCVWQLTVQFPSAFQFTPSFLVKFVSLTASSIYSNFVFDSAKARVEASNHSKRSSYYV
.|||. .|| |..|.|       ..|   | ..|.|. | |||.||| |||. |.|  .||.| .    |. . .|..|| | |...  ...  | . 
ekewlsfGhkfaqRigq......ttekssdersPiflqFidcvyqltkqfptsFeFnekflikildalyscrfgtFLydsekeRqqnnlaketvslWa
subfamily_MTMR6_pd Subfamily MTMR6 706-895 8.9e-38 122.6 In-house 175-352 (397) alignment 
Range on Protein: 706-895
Range on HMM: 175-352/397.0
YSKLMEVCTistchDLARADQKWLATLDSSHWLHYVKSCLSLASDIVKTLCEKRTSCVLLDQNDRDLACVISSLVQIMADPHYRTISGFESLVQKEWVAM
 .||.||.        ... ...| .|.|| ||...|. |  .  | |.. |...|...   .  | .. . || ... ||.|||| ||  |..|||...
lqkllevve.....lksksvseflsglessgwlkhikavldasifiakavaeegasvlvhcsdGwdrtaqvcslasllldpyyrtikGflvliekewlsf

GHPFTTRSGLITDAPsnEELvpdgqAPVFVLFCDCVWQLTVQFPSAFQFTPSFLVKFVSLTASSIYSNFVFDSAKARVEASNHSKRSSYY
|| |..|.||. ...   |.     .|.|  | .|||||. ||| ||.|  .||...     |. . .|. .. |.| ..  . .  | .
GhkfsercGlldeds..kev.....sPiftqflecvwqlleqfpkafefnerfllelhdhvyscqfGtflgncekdrrdlklkertkslw
subfamily_MTMR3_pd Subfamily MTMR3 719-891 1.2e-37 122.8 In-house 230-396 (442) alignment 
Range on Protein: 719-891
Range on HMM: 230-396/442.0
HdLARADQKWLATLDSSHWLHYVKSCLSLASDIVKTLCEKRTSCVLLDQNDRDLACVISSLVQIMADPHYRTISGFESLVQKEWVAMGHPFTTRSGLITD
.  .  ...||..|.. .||. .   |  |  .|... ..  . ..   .  | .  | .| ... ||.|||. ||. ||..||...|| |. |.|   .
s.qspdesnwlsalektkWlqnlsvllkaavkvveavdkegrpvlvhCsdGWdrttqivalakllldpyyrtleGfkvlvereWldfGhkfadrcghgen

APSNEElvpdgQAPVFVLFCDCVWQLTVQFPSAFQFTPSFLVKFVSLTASSIYSNFVFDSAKARVEASNHSKR
   ..|     ..|||. . |.| ||. |||..|.|. .||||.|  | |...  |...|.|.| | . ... 
vddane.....rcPvflqwldavhqlqrqfPtsfefneaflvklvqhtysclfGtflansekereeekvkert
subfamily_pats1_pd Subfamily pats1 720-812 1.3e-15 48.8 In-house 362-456 (691) alignment 
Range on Protein: 720-812
Range on HMM: 362-456/691.0
DLARADQKWLATLdSSHWLHYVKSCLSLASDIVKTLCEKRtScVLL----DQNDRDLAC-VISSLVQIMADPHYRTISGFESLVQKEWVAMGHPFTTR
.|  .|..|  .   |.|.  ||  |. | .. . | | . | |||    |  . .|    |||| |...||.|||. ||  |..|||.  |.||. .
sldgsddewkeie.eskwvdsvkllleaavkvsnlldeGs.s.vllknsidsPlieldlasisslaqvlsdPfyrtldGfkvliekewlsyGfPfski
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 722-895 1.9e-29 94.6 In-house 197-362 (405) alignment 
Range on Protein: 722-895
Range on HMM: 197-362/405.0
ARADQKWLATLDSSHWLHYVKSCLSLASdIVKTLCEKRTSCVLLDQNDRDLACVISSLVQIMADPHYRTISGFESLVQKEWVAMGHPFTTRSGLItdaPS
  .| ..  ... . |. ..|| |  |. .   |  |  | ..   .  | .  |.|| ||. ||.|||| ||. |..|||...|| |. | | .   | 
estdmrfwgyieetgwishiksileaat.fsaelilkgnsilvhcsdgwdrtpqitsltqilldpyyrtivgfqvliekewlsfghkfslrlghl...pg

NEElvpdGQAPVFVLFCDCVWQLTVQFPSAFQFTPSFLVKFVSLTASSIYSNFVFDSAKARVEASNHSKRSSYY
|||     ..|.|  | ||..||  |||  |.||||.|.       |  |  |. .  | ||.   . |  | .
nee....erspifqqfldccfqllsqfpllfeftpslllfisdnihsckygtflnncekdrvqdqvktktisiw
subfamily_pats1_pd Subfamily pats1 819-895 9.7e-12 36.0 In-house 541-617 (691) alignment 
Range on Protein: 819-895
Range on HMM: 541-617/691.0
APSNEELVPDGQAPVFVLFCDCVWQLTVQFPSAFQFTPSFLVKFVSLTASSIYSNFVFDSAKARVEASNHSKRSSYY
   .  ||  . .|.|| | | ||||  .||  |.|  |.|. .|  . || . ||... || ..|    ..  |..
qyessilvnrsfsPifvqfldlvwqlqkefPfhfefneslllllvkesfssrfGnflyseakrdserkvlkrsksiw
DUF3584 Protein of unknown function (DUF3584) 1057-1174 2.3e-06 12.5 Pfam-A 816-937 (1201) alignment 
Range on Protein: 1057-1174
Range on HMM: 816-937/1201.0
QLQSKLVKEVRKLKEALNDLELERGEQTSDFSRFIREIMKARDEE-KRLRKLKRDAS--HEIARRMsAFITMSSEDEDCDRSLDKLNSPVGSVHDKAKTL
. . .| .....|...|..|| |......|  . .....|.|.   |.| .|.   .  ..  ... |.. .. ..|. . .... .. .  . .| | |
eerpalkeqleelessleeleqelarlikdlklerkklekerkalekqldqldeelrklrdelskl.aelkldknaeqaegevserlaaleelkrkrkrl

PAKLDDSLSKFADEL--HNNGEV
 ...   |..|   |  |.  |.
seavkkalerfkgvlkdhsgsel