Gene PTPRB in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRB
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP061_AA protein Get Run
AqueP061_AA_863-1137 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
fn3 Fibronectin type III domain 2-71 1.4e-10 34.4 Pfam-A 15-84 (85) alignment
Range on Protein: 2-71
Range on HMM: 15-84/85.0
SLRITWTELLedDQNGVIIGYNISYFSLPAVG--QPINNFTSDTSYNISGLDVYTDYNVSVAAYTSAGTGPF
||...|..    |..| | ||.. | .    .  . ...  . ||....||  .|.|...|.|.. ||.||.
sltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe

fn3 Fibronectin type III domain 85-167 3.6e-16 52.2 Pfam-A 2-85 (85) alignment
Range on Protein: 85-167
Range on HMM: 2-85/85.0
SPSDVSYINISSTSIEVSWNPPTDFNGPNEGYVITYIRLESDT-ESMSTNRLTGTSFVIENLEKYEQYSVTVVAFTDKGPGASS
.|...| ....|||...||.||.| .|| .|| ..|   ..   .   |.  | ||.....|. . .|...| | ...| | .|
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS

fn3 Fibronectin type III domain 181-267 4.7e-11 35.9 Pfam-A 2-84 (85) alignment
Range on Protein: 181-267
Range on HMM: 2-84/85.0
PPSNVSTMS-TNTSISITWSPPLDPNGLLLSYSINVTLNSTYAqylsfDVMTMSVSQNIFSYTLFDLLPFAGYDISLQASTSVGLGTP
.|.|.|  . |.||....|||| |..| . .|.. .   ..       .  . .|. .  |.|| .| | . | ...|| . .| | .
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge.....ewkeftvprtttsvtltgLkpgteYefrVqavngagegpe

fn3 Fibronectin type III domain 282-379 2.2e-09 30.5 Pfam-A 2-80 (85) alignment
Range on Protein: 282-379
Range on HMM: 2-80/85.0
PVANPMASPVSSTAVNVSWLPPNlsNWNGLITNYTIEYRTNDEYIrpsievtatlssfansdDPRAATTPLQLESIIIPSLHEFVNYSFIITLSNSIG
.. |. .|.|.|| ...|| ||.  ...| ||.|..|||. ..                   ...  |.| . .| ... | .  .|.| ..  |  |
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekggge.................ewkeftvprtttsvtltgLkpgteYefrVqavngag

fn3 Fibronectin type III domain 398-483 1.7e-11 37.3 Pfam-A 2-85 (85) alignment
Range on Protein: 398-483
Range on HMM: 2-85/85.0
PPLDVSVIVDSPSTARISWSPPMyiDRNGIIVNYTVRIITTVRGT-IRETNISNVSGnYYDASDLPQFASFNVTVAAATSVGLGPYS
.| ..||.  .......|||||   |..| |..|.|.  ..  |   .| .... .   .  ..|   ......|.| . .| ||.|
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngagegpeS

fn3 Fibronectin type III domain 496-586 1.8e-14 46.8 Pfam-A 1-82 (85) alignment
Range on Protein: 496-586
Range on HMM: 1-82/85.0
SAPDPVIVKRRNDTAIQVNWTRPAEPNGIILGYLIYYIGTKNNTgteysninvlIIINVTDPNTL-SYLITNLLADTQYFINVTAYTSAGLG
|||  . |. ...| ....|. |....| | || . |  . ..              ..| |.|  |. .|.| ..|.| ..|.|.. || |
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge..........ewkeftvprtttsvtltgLkpgteYefrVqavngageg

Uroplakin_II Uroplakin II 720-793 9e-06 11.5 Pfam-A 109-180 (184) alignment
Range on Protein: 720-793
Range on HMM: 109-180/184.0
LKPGTQYQFKYRVYNSDDDDSYVESqysgPIRTDPIAEENNTGTTIVIAVVVVLLVIILLIAIL--VIVVIIVLKR
| |||.|   |.| .    .|  |     |. | |  . .. | ..  .  .|.. ..| .|..  |. .|| |. 
lvpgtkyyisylvkkgastessrei....pmstlprknmesiglgmartggmvvitvllsvamfllvlgliialal

m04gp34like Immune evasion protein 733-798 8.3e-06 11.6 Pfam-A 201-266 (272) alignment
Range on Protein: 733-798
Range on HMM: 201-266/272.0
YNSDDDDSYVESQYSGPIRTDPIAEENNTGTTIVIAVVVVLLVIILLIAILVIVVIIVLKRRKRKA
|.. |. ... ..|. .. | ..  ..|... . |. |.| |.|......| ..    | ||....
yevpdtlpkkrvaydyasetkredvsdnrallvtilsvivvllivvvllvLaylYgpsllrrlssr

Herpes_gE Alphaherpesvirus glycoprotein E 737-804 2.5e-06 16.1 Pfam-A 323-388 (439) alignment
Range on Protein: 737-804
Range on HMM: 323-388/439.0
DDDSYVESQYSGPIRTDPIAEENNTGTTIVIAVVVVLLVIILLIAILVIVVIIVLKRRKRKAYSfaAS
..|| ....   | ... .|....  ..  . ...|| ...||. .|..|...| |||.||||   ..
aadseesdppatpapsaepakpeartapyllllaavlgaavlllvvlllvlvcvtkrrrrkaye..kr

Rifin_STEVOR Rifin/stevor family 742-797 5.9e-06 16.9 Pfam-A 231-286 (299) alignment
Range on Protein: 742-797
Range on HMM: 231-286/299.0
VESQYSGPIRTDPIAEENNTGTTIVIAVVVVLLVIILLIAILVIVVIIVLKRRKRK
.|..  . | .  .|  ...  ..  |...  ..|.. .....|.  | . |||.|
aeedvteaikkketalieskfaslttaIiasviailiIvlvmlIIylilrYRRKkK

DUF4064 Protein of unknown function (DUF4064) 752-799 2.8e-06 15.4 Pfam-A 46-86 (100) alignment
Range on Protein: 752-799
Range on HMM: 46-86/100.0
TdpiaeeNNTGTTIVIAVVVVLLVIILLIAILVIVVIIVLKRrKRKAY
.      ..|.....  .|..|....... || |...|..|. |.| .
k......eetildllstlvlilgilaiilsilgiigsilvkk.kpkls

DUF912 Nucleopolyhedrovirus protein of unknown function (DUF912) 752-796 5.3e-06 16.9 Pfam-A 54-92 (101) alignment
Range on Protein: 752-796
Range on HMM: 54-92/101.0
TdpiAEENNTGTTIVIAVVVVLLVIILLIAILVIVviiVLKRRKR
.   ||....  ...|....|| |..||..|. .|   .|..|..
k...aekaqatnillisllavlcvlvllyviyYFv...ilrerqk

TMEM154 TMEM154 protein family 757-798 9.3e-06 17.0 Pfam-A 51-89 (146) alignment
Range on Protein: 757-798
Range on HMM: 51-89/146.0
EENNTGTTIVIAVVVVLLVIILLiaiLVIVVIIVLKRRKRKA
..... . ..|..  |.|...||   .|....|. ||..|| 
sadqaelvlmiiiPsvvLillll...vvvilvikkkrkrrKq

0050432 (Phosphotyrosine protein) phosphatases II 854-1139 8.8e-104 342.4 In-house 19-302 (308) alignment
Range on Protein: 854-1139
Range on HMM: 19-302/308.0
ATPNSRKVYLRDFPSYVEDmlNDAGFKFSEEYEKVSAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLesiddEPGSDYINANYIPGY--RMRRAYI
 ...| |... |.  ..|.   .   ...||.|.. .|  ... ...|||||. ||||..||.||||||||     ..|||||||.|..||  . .|..|
ilvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfI

ATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGA---QPEVYGEINVDMLSETEKSDWIVRKFKITK--EKRSRTITHYQFVSWPDHG
|||||||.|..||||| ||||..||||||.|||.|| ||..|||     ....|| . | .|||....|..||....|.  .. |||.||... .|||||
atqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhg

VPDEAGPALDFVREVHEVASSafGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKSS
||... . |||...|... ..  ||..|||||||||||||||| .||.... . .||.|..   .|..|..|.||. ||.|...|... .|. 
vPpspeilldflelvrkslpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklk

0045450 (Phosphotyrosine protein) phosphatases II 856-1135 1e-93 309.7 In-house 4-303 (307) alignment
Range on Protein: 856-1135
Range on HMM: 4-303/307.0
PNSRKVYLRDFPSYVEDMLNDAGFKFSEEYEKVSAVGL--DHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDE-PGSDYINANYI--------PGY
| |... .... ..|  .| |   .. .|.||.  |     .. ...|||||. ||||..||.|||.|||| |.|.. ..||||||.|.        .||
plslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgy

RMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGA-QPEVYGEINVDMLSETEKSDWIVRKFKIT---KEKRSRTITHYQFV
.  |..||||||||.|..||||| |||...||||||.|||.|| ||..|||   .. .||.. | .|||.......||....|   ... |||.||... 
dlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhyt

SWPDHGVPDEAGPALDFVREVHEVASS--AFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDW---VDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDA
.|||||||.   ..|||..||... ..    |||.|||||||||||||||. ..|...... .   |||.   ...|..| ...|.. ||.|...|. . 
gwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel





subfamily_PTPRB_pd Subfamily PTPRB 857-1141 4.1e-135 444.5 In-house 3-290 (293) alignment
Range on Protein: 857-1141
Range on HMM: 3-290/293.0
NSRKVYLRDFPSYVEDMLNDAGFKFSEEYEKVSAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGP
.|... |..| ..|..| .|. ..||||||...||| |....|. |..|||||||||||.||||||||....||.|||||||||||||...| .||||||
kskpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGP

LPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGA-QPEVYGEINVDMLSETEKSDWIVRKFKITKEKRSRTITHYQFVSWPDHGVPDEAGPAL
||.|.||||||.||..|..|||||||||.|..||..|||   .| .||.|.|....|.|..||..|..||.|||..|....|.|.||||||||... . |
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktll

DFVREVHEVA--SSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKSSMS
||||.|.|..  ... .|..|||||||||||||||| .|||.|...|.||.||. .|.|..||...||| ||.|||....| ......
dfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkkee

0039614 (Phosphotyrosine protein) phosphatases II 857-1136 4.3e-95 313.8 In-house 10-289 (297) alignment
Range on Protein: 857-1136
Range on HMM: 10-289/297.0
NSRKVYLRDFPSYVEDMLNDAGFKFSEEYEKVSAVGLDhsKDASLLPENRAKNRYTNILAYDHSRVKLESIDDE-PGSDYINANYIPGYRM-RRAYIATQ
.|  ..|. .. ..  .  .   .. .|.|..  .  |  .  .|||||. ||||..||.|||||||| ..|.  ..||||||.|..||..  |..||||
esipiplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatq

GPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRtKCHRYWPGAQPeVYGEINVDMLSETEKSDWIVRKFKITKEKRSRTITHYQFVSWPDHGVPDEAGPA
||||.|..||||| |||...||||||.|||.|| ||..|||  .  .||.. | .|.........||....|... |||.||.|...|||||||. .   
gPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslell

LDFVREVHEVASS--AFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDAC
|.|...|.|. ..    |||.|||||||||||||||. ..|.... .  ||..   .|.|..|....||. ||.|...|... .
leflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 859-946 4.4e-15 49.9 In-house 4-88 (440) alignment
Range on Protein: 859-946
Range on HMM: 4-88/440.0
RKVYLRDFPSYVEDmlNDAGFKFSEEYEKVsAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRM
| . . ||  ||..  |     | .|.  .   || .  | . ||.|. |||| |||||||||| || .   | |||||| || |   
rpiivadfadyvqn..nrrsrafedewsll.psglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingies

subfamily_PTPRD_pd Subfamily PTPRD 860-1138 6.4e-125 412.9 In-house 4-283 (564) alignment
Range on Protein: 860-1138
Range on HMM: 4-283/564.0
KVYLRDFPSYVEDMLNDAGFKFSEEYEKVSAVgLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPS
..   .....|. .  . ..||.|||.|..     ....|.  |.|.||||| ||.|||||||.|.... ..|||||||..| ||| |.|||||||||..
pipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlae

TFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPEVYGEINVDMLSETEKSDWIVRKFKITK--EKRSRTITHYQFVSWPDHGVPDEAGPALDF
|..||||| |||||..|||||.|.|.|..|||.|||  ..| |||. |.. .|.|..| ..|.||..|  .. ||......|.||||||||..| . ||.
tiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdl

VREVHEVASSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKS
.|.|......  ||..||||||||||||||..  .|. ||. . ||...  ...|..||.|.||| ||.|||.|...| ..
irkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealac

0051299 (Phosphotyrosine protein) phosphatases II 860-1136 1.8e-106 351.1 In-house 4-286 (288) alignment
Range on Protein: 860-1136
Range on HMM: 4-286/288.0
KVYLRDFPSYVEDMLNDAGFKFSEEYEKVSAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPS
 . .... ..|. .| .   .. ||.|.. ..  |..  |.|||||. ||||..||.|||||||| ..|...|||||||.||.||.. |..||||||||.
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn

TFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPEVYGEINVDMLSETEKSDWIVRKFKIT------KEKRSRTITHYQFVSWPDHGVPDEAGP
|..||||| ||||..||||||.|||.||.||..|||  ....||.| | .|||....|..||....|      ... |||.||... .|||||||| . .
tvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspel

ALDFVREVHEVASSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDAC
 |||.|.|... .|  |||.|||||||||||||||| .||.... . .||....   .|..|..|.||. ||.|...|.....
lldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

subfamily_Ptp69D_pd Subfamily Ptp69D 861-1137 1e-85 282.6 In-house 4-287 (307) alignment
Range on Protein: 861-1137
Range on HMM: 4-287/307.0
VYLRDFPSYVEDMLNDAGFKFSEEYEKVSAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPST
. . | .. ..   .|. | . .||||. |   |.|  .|   ||  |||| .| |.|. ||||. |  .  ||||||..| ||. .. .|| |.|. .|
iaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveat

FDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPEVYGEINVDMLSETEKSDWIVRKFKITKEK-------RSRTITHYQFVSWPDHGVPDEAGP
 .||||| .||....||||..| |  | ||..|||  .   ||.|.|.. || ..||.| |.....| |        || .. |.. .|.|  ||. |  
igDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevarg

ALDFVREVHEVASSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACK
 |.....|.|. .   .|..|||||||||.|.|.||  |||..|  | ||.|    ..|..|| ..|   ||||...|..|  .
llklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss

subfamily_PTPRG_pd Subfamily PTPRG 862-1139 2.2e-98 324.9 In-house 2-290 (563) alignment
Range on Protein: 862-1139
Range on HMM: 2-290/563.0
YLRDFPSYVEDMLNDAGFKFSEEYEKVS--AVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGS-DYINANYIPGYRMRRAYIATQGPLP
 ...| ..| ..  |.  .||||.|..    .  |   ..|  |||. ||||.||.|||.|||||... .. .. |||||||| ||.  .|.|||||||.
pvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplk

STFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPEVYGEINVDMLSETEKSDWIVRKFKITK-----EK---RSRTITHYQFVSWPDHGVPDE
.|||||||| ||||...|||.|.|||||| ||..|||  ..| ||...| . .|  ..   ||...| .     .|     .....|.. .|||||||. 
dtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPeh

AGPALDFVREVHEVASSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKSS
. | | ||.       .. ||..||||||||||||.|.| |||. |.... |..||..  .| .||...||| ||.|.|.|...| .| 
slpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiask

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 862-1138 2e-83 275.0 In-house 5-285 (305) alignment
Range on Protein: 862-1138
Range on HMM: 5-285/305.0
YLRDFPSYVEDMLNDAGFKFSEEYEKVSAVglDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTF
 | |. .|....  .   .. ..|...     ..| |     .|.||||...|  .|..|..|   .... ||||||.|. ||. . .||..||||..| 
alddlaayikearvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntv

DDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPE--VYGEINVDMLSETEKSDWIVRKFKITK---EKRSRTITHYQFVSWPDHGVPDEAGPALD
.||||. .|   ..|||||.||| |. ||..|||... |   .||..| . ||.. ||.| ||.||..   .| |||...||. .|||||||..|.  |.
adfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatslls

FVREVHEVASSAFG-PVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKS
....|..  ..  | |..|||||||||||.|||.   |...|  . ||.|..  ..|..|  |.||  ||||.| |. .  ..
likrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitc

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 862-955 4.4e-11 36.8 In-house 6-95 (95) alignment
Range on Protein: 862-955
Range on HMM: 6-95/95.0
YLRDFPSYVEDMLNDAGFKFSEEYEKVSAV-GLDHSKDASllPENRAKNRYTNILAYDHSRVKLESIDDepgSDYINANYIPGYRMRRAYIATQG
..  | |.| .|  ..  .| .|.  .|   |  ..  .|    |  |||. ||. || .|| | .  |   |||||| .. ||  . .|||.||
hvsvfhshvlemhsnsdqefdnefksismtsgapytvgss..eanipknrflnifpydatrvvlttkrd...sdyinacfvdgyarkncyiaaqg

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 863-1139 1.9e-113 373.7 In-house 4-283 (318) alignment
Range on Protein: 863-1139
Range on HMM: 4-283/318.0
LRDFPSYVEDMLNDAGFKFSEEYEKVSAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFD
..|. | |. . ..   ..|||||..| .    ..  || | |.|||||.|||||||.||||. ...|.||||||||||.||| ..||||.|.||| |..
vedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetie

DFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPEVYGEINVDMLSETEKSDWIVRKFKITK--EKRSRTITHYQFVSWPDHGVPDEAGPALDFVRE
||||| ||||| |||||||..|||..|.|||||. ... ||.. |.. .|.| ||...|.||.|.  |. ||..  |.. ||||.|||....  ||.||.
DfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrq

VHEVA-SSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKSS
|...  .|  ||..|||||||||||.|||. .||..||.   ||.|.  ...|..|| |.||| ||.||......| .| 
vskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasg

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 863-1134 8.4e-79 259.6 In-house 5-275 (315) alignment
Range on Protein: 863-1134
Range on HMM: 5-275/315.0
LRDFPSYVEDmlNDAGFKFSEEYEKVSAVGLDHSKdASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFD
. .||..|.   |     ||||.  .      . . ..  ..|  |||| ||| .|..||||| |||.| |||||| ||...   .||||.||||... |
vaqfpafvnk..nrhtalfseefhdlpdPdiyrqr.varetinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvd

DFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPG--AQPEVYGEINVDMLSETEKSDWIVRKFKITKEKRSRTITHYQFVSWPDHGVPDEAGPALDFVRE
||||| ....   |||.|.. |  . || .|||   |.   .|.|.|..||    .| ..||. . | . |||.| .||  |||.||. ...  | ...|
dfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklike

VHEVASSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVD
|     .   ...||||||||||| .|..   ...||. . ||.| .  ..|..| ...||| .| ||. |. .
vkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavle

0043336 (Phosphotyrosine protein) phosphatases II 864-1134 3e-97 320.7 In-house 5-275 (278) alignment
Range on Protein: 864-1134
Range on HMM: 5-275/278.0
RDFPSYVEDMLNDAGFKFSEEYEKVSAVGLdHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDD
 |.. .....| .   ....|.|..  . |  ... .|||||. ||||..||.||||||||.... ...||||||.|..||.. |..||||||||.|..|
kdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetved

FWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPgAQPEVYGEINVDMLSETEKSDWIVRKFKIT--KEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREV
|||| ||.....|||||.|||.||.||..|||  ....||.. | .|.|....|..||....|  ... |||.|||....|||||||.   . |||...|
FwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkav

HEVASSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVD
.|. ..  |||.|||||||||||||||| .||......  |||.   .|.|..| ...||. ||.|...|. .
realedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 864-1158 8.8e-82 270.0 In-house 14-308 (319) alignment
Range on Protein: 864-1158
Range on HMM: 14-308/319.0
RDFPSYVEDM-----LNDAGFKFSEEYEKVSAVGLDHS-KDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPL
.||| |  ..     ..|   |.  |. ... .| . . .. . |..|. |||..||||.|...|||| .. | .|||||| .. ||. .  |||.||||
pdfpayyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPl

PSTFDDFWRMTWEQNSHVIVMLTqlvergRTKCHRYWPGAQPEVYGEINVDMLSETEKSDWIVRKFKITK---EKRSRTITHYQFVSWPDHGVPDEAGPA
. | .||||| ||.|.  ||.||      . || .|||    . ... .|.. | .| ....||......   ||  | || . |  |||.|||| . . 
dntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdl

LDFVREVHEVASSAF--GPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACkssmsKFGGGIKVLPS
. .|. |. . |      ...|||||||||||..|.| .||. .|. . ||.. .  ..|| ||...|   || ||. |...        ||    ..| 
mrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh.....lfghsdvampd

FPIYSN
|| | .
fpayle

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 864-1134 2.4e-79 261.8 In-house 5-274 (515) alignment
Range on Protein: 864-1134
Range on HMM: 5-274/515.0
RDFPSYVEDmlNDAGFKFSEEYEKVSAVGLDHSKdASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDD
 .||..|.   |     ||||.  .    .      .    |  |||| ||| || .||||| |.|.| |||.|| |||..   .||||.|||.... ||
aqfPafvnk..nrhttlfseefhdlpgpniypqt.vaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvdd

FWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPG--AQPEVYGEINVDMLSETEKSDWIVRKFKITKEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREV
|||. ...|   |.|.|.| |  . || .|||   ..   .|.|.|...|    .. | ||....|.. |||.| ..|  |||.||| ..   | ...||
fWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikev

HEVASSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVD
    .    |.|.|||||||||| .|..   . |.|. . ||.| .   .||.| ...||. || ||. |. .
kadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavle

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 864-1138 5.5e-68 223.9 In-house 5-285 (290) alignment
Range on Protein: 864-1138
Range on HMM: 5-285/290.0
RDFPSYVEDMLNDAGFKFSEEYEKVSAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPG--SDYINANYIPGYRMRRAYIATQGPLPSTF
 .|  .|.        .| ...... .   .|.    | ..|. .||..||. ||  |. |  | ...    .|||| || ||. ...|||||||...| 
dkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntl

DDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPEVYGEINVDMLSETEKSDWIVRKFKITKEKR---SRTITHYQFVSWPDHG-VPDEAGPALDF
 |||.. |.... .|||||. .| |..||. ||| .. . |||... .|.|.. .. | ||.......    ....|.||. .|...| |.....  | .
vdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvi

VREVHEVASSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKS
 . ..    .  ....||||..|||...|.|. | ... |    .|.| .  ..|. .  ..||. || .|.. .. . .|
eemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 864-1134 7.3e-61 200.7 In-house 7-234 (392) alignment
Range on Protein: 864-1134
Range on HMM: 7-234/392.0
RDFPSYVEDMLNDAgfKFSEEYEKVSAVGLDHSKDAsLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDD
 .||..||.    |   |.||.  .    . . . |   . |  |||| ||| || .||||| ||| | |||.|| |||..   .||||.||| ....||
aqfpafveknrhsa..lffeefhdlpgpdiypqtva.qkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaasldd

FWRMTWEQNSHVIVMLTQLVERGrtkchrywpgaqpevygeinvdmlseteksdwivrkfkitKEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHE
|||| ...|   |.|.|.| |                                          | .  ||.. ..|. |||..||  .   | |..||. 
fwrmvfqenvttiamvtklkegd........................................kgddartvaqfhftewPdkdvpkhtssllkfikevka

VASSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVD
   .   |.|.||||||||||  |.. ... | |    ||.| . ...|..| .|.||. || ||. |...
dfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle

0040438 (Phosphotyrosine protein) phosphatases II 865-1138 1.9e-99 328.2 In-house 4-278 (317) alignment
Range on Protein: 865-1138
Range on HMM: 4-278/317.0
DFPSYVEDMLNDAGFKFSEEYEKVSAVGLDhSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDF
|.. ...|.|.    ...||.|..  . || . . ..||||. ||||..|| |||||||| ...  ..||||||.|..|.. .|..||||||||.|..||
dlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedF

WRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPEVYGEINVDMLSETEKSDWIVRKFKIT--KEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVH
||| |||...||||||.|.|.|| ||..|||  .. .||.. | .|||.|......|.....  ... |||.||... .|||||||.   . |||...|.
wrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavr

EVASSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKS
|. ..  |||.|||||||||||||||. ..|.... .  ||..    |.|..|....||. ||.|...|. . .| 
ealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkr

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 865-1135 3.4e-65 215.2 In-house 6-278 (439) alignment
Range on Protein: 865-1135
Range on HMM: 6-278/439.0
DFPSYVEDMLNDAGFKFSEEYEKVSAVGLDHSKDASLLPEN--RAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFD
.|  .||.. ..    |.|..||....  |.. .|||. ..  ..|||| .. |.||.|| |. |   | | ||||||| ||   . |||||||   | |
efqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettd

DFWRMTWEQNSHVIVMLTQLVERGRtkchrYWPGAQPEVYGEINVDMLSETEKSDWIVRKFKITKE----KRSRTITHYQFVSWPDHGVPDEAGPALDFV
||||. .|...  |||||.|||  .     |||  .  .||.| | .  . |  ....| ||. .|    .. ||. ......|||. || .|   |||.
dfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldfl

REVHEVA-SSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDA
| .     .  .|||.|||||||||||| |||   |...|  . ||. |. . .|..|..|.|.  |||||..|... 
rainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavled

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 867-1139 6.8e-97 319.4 In-house 11-286 (319) alignment
Range on Protein: 867-1139
Range on HMM: 11-286/319.0
PSYVEDMLNDAGFKFSEEYEKVSAVGLDhSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWR
 .... . . .  .. .|.....  . | . | .  .||. ||||.||||||..||.| ..|. .|||||||..| ||. |...||||.||  |..||||
kerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWr

MTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPEVYGEINVDMLSETEKSDWIVRKFKITKEK---RSRTITHYQFVSWPDHGVPDEAGPALDFVREVHE
| ||..|...||||.|||... |...||| ...|.||.. |....| |..|.|.||.|. | .    .|...|.|. .||||.||..|   ||.......
mvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirk

VASS-AFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKSS
  .    ||..||||||||||||||.|   |...|    .|.|  .|..|  || |.|.. || ||..|...| .. 
srektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveag

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 868-1138 2.1e-92 304.6 In-house 16-292 (298) alignment
Range on Protein: 868-1138
Range on HMM: 16-292/298.0
SYVEDMLNDAGFKFSEEYEKVSAVGL---DHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDF
 ... . .    ....|......|     ...|...  |||. ||||..|.|.|.||| ||..|..  |||||| .. .|. | |.||||.||..|. ||
klaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedF

WRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPEVYGEINVDMLSETEKSDWIVRKFKITKEK--RSRTITHYQFVSWPDHGVPDEAGPALDFVREVH
||| .|... .|||||.|.| ..||.|.|||  . | ||||.|..||. |..| ||||.|..|.|  ..|.. . .|.||||.||| .|   ||..|.|.
WrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvr

EvASSAFG--PVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKS
    .  |  ||||.|||||||.|||||. ..|...|    ||.|     .|..| ...||| |||||..|. .| .|
a.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealds

subfamily_PTPRN_pd Subfamily PTPRN 868-1135 2.8e-61 201.8 In-house 19-291 (297) alignment
Range on Protein: 868-1135
Range on HMM: 19-291/297.0
SYVEDMLNDAGfKFSEEYEKVSAVGLDH-SKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRR-AYIATQGPLPSTFDDFW
||.|| |..   ....|.| . |   .  .|...  ..|  |||....|.||||||||..  ..  ||||||  |     |. |||||||||.||  |||
syledhlknkd.rlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfw

RMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPEVYGEINVDMLSETEK-SDWIVRKFKI--TKEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVH
.| ||| . |||.||.| | | ..|.||||    |||.  .|...||     |..|| | .   . ...||.| . |.|||..||| .| . |.| | | 
qmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvn

EVASSAFGPVIVHCSAGVGRTGTFIALGTLLQHI-KDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDA
        |..||||.|.||||..|..  .|... |    .|.      .|. |.....|. |. |. .|... 
ksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 869-1139 2.6e-66 218.5 In-house 10-281 (287) alignment
Range on Protein: 869-1139
Range on HMM: 10-281/287.0
YVEDMLNDAGFKFSEEYEKVSAVGL-DHSKDASLLPENRAKNRYTNILAYDHSRVKLEsiddEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRM
.|..  .     |.. .  .  |.  ...   .. ..|. |||.|.|| .|  || |.    .   ||||| .| ||. ..|.|....|. .|  .||..
fvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkl

TWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPEVYGEINVDMLSETEKSDWIVRKFKITKEK---RSRTITHYQFVSWPDHG-VPDEAGPALDFVREVHE
 ...| ..||||.|. |  . .|..|||  .  |.|| |. .|.|. ....|.||.......     .... ||. .|...| |.. .   | . . ...
iddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemykt

VASSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKSS
   .. ....||||..|||...|.|  | ... |    .|.| .  ..|. . ...||  || || ....   .| 
qrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsf

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 869-1133 3.1e-49 162.7 In-house 6-274 (307) alignment
Range on Protein: 869-1133
Range on HMM: 6-274/307.0
YVEDMLNDAGFKFSEEYEKVSAVGLDHsKDASLLPENRAKNRYTNILAYDHSRVKLESidDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMT
.|.  |.    .. .|.....    .    .  .  |  ||||... . |..|. ..   |   |||| |||.      . .|..|||| .|  .|| |.
wvqrtldkgvqalvdefrvlakktpeg.vtveafsantdknryqdvkcqdkgrivvkf..dglasdyihanylgiaikpkkficaqgplentqysfwama

WEQNSHVIVMLTQLVERGRTKCHRYWPGA--QPEVYGE----INVDMLSETE---KSDWI-VRKFKITKEKRSRTITHYQFVSWPDHGVPDEAGPALDFV
 ...   ..|| ...| .. ||..|||    |  |.||    |.|. |   .     | | | ..|.   ..||||.|.|.  |||.|||.    |....
iqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainll

REVHevasSAFGPVIVHCSAGVGRTGTFIALGTLLQH-IKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMV
  |.        ||.|||||||||.|| .|.  . .  |.  .  |.  |  |.|..|.. |||| ||...|. ..
eavr....ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvll

subfamily_PTPRK_pd Subfamily PTPRK 870-1138 4.7e-88 290.0 In-house 13-279 (314) alignment
Range on Protein: 870-1138
Range on HMM: 13-279/314.0
VEDMLNDAGFKFSEEYEKVSAvGldhsKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTW
.  .    |. | |||| .   |     ||.   |||.|||...|||||.|||.| .||..| ||||||..| .|.  .|.|.|||||..|  ||||. .
iallkraegygfkeeyeslfe.g....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvy

EQNSHVIVMLTQLVERGRTKCHRYWPGAQPEvYGEINVDMLSETEKSDWIVRKFKITK----EKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVA
..|.  |||||.||| || || .|||      ||.|.| ... . ... .|| |...|     .  |.. ..||..||||.|| .|   |..||.|..  
dencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksq

SSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKS
    |...|||||| ||||||||. ..|. |. .. ||.|  . ..|...  |..|| ||.||. ....||  
eeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclc

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 873-1136 2.3e-100 330.4 In-house 15-279 (288) alignment
Range on Protein: 873-1136
Range on HMM: 15-279/288.0
MLNDAGFKFSEEYEKVSAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQN
.  ..   |||||....|.. ..|..|. |..|  |||| |||.||. ||||.  ..|.|.|||||.|| |.. ...||||||||..| .|||.. .|..
ksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenk

SHVIVMLTQLVERGRTKCHRYWPGAQ-PEVYGEINVDMLSETEKSDWIVRKFKITKEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAFGP
.. |||||.|||.|.|||..||| |. |. ||...| .... |. |...||. . |.|  ..||.||. .|||||||. . | |...| |.   ..  ||
tstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgp

VIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDAC
.||||||||||||||||| .|..... .| .|..|  ...|..|. ..||. ||.||......  
iivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli

0045098 (Phosphotyrosine protein) phosphatases II 875-1134 3.2e-87 287.7 In-house 3-270 (278) alignment
Range on Protein: 875-1134
Range on HMM: 3-270/278.0
NDAGFKFSEEYEKVSAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKlesiddepgsDYINANYIPGYrmRRAYIATQGPLPSTFDDFWRMTWEQNSH
..|  ... |.| . . |   .   .|...|..||||..||.|||||||          |||||.||.||  ....||||||||||..||||| ||....
alasldlllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgit

VIVMLTQLVERGRTKCHRYWPGAQPEVYGEINVDMLSETEKSDWIVRKFKIT------KEKRSRTITHYQFVSWPDHGVPDEA--GPALDFVREVHEVAS
||||||.|||.|| ||..|||  ....||.. | .|||.. .|...|....|      ..  ||..||.....|||||||..    . |.......|. .
vivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealk

-------------SAFGPVIVHCSAGVGRTGTFIALGTLLQHIkdHDWVDLFGLASEMRQHRNH-MIQTEPQYVFIHKAMVD
             .  |||.||||||||||||..|. ..|...  .. |||.   .|.|..|.. ..|.. ||.|.......
llaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyeflle

subfamily_PTPRA_pd Subfamily PTPRA 875-1134 4.8e-87 286.9 In-house 28-293 (330) alignment
Range on Protein: 875-1134
Range on HMM: 28-293/330.0
NDAGFKFSEEYEKVSAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSH
 |   .| ||.. . |  .. . ...   ||. |||. ||| ||.||| |  .. .. |||||| .| ||. .  .||.|||.  | .||||| |||.|.
addnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksa

VIVMLTQLVERGRTKCHRYWPGAQPEVYGEINVDMLSETEKSDWIVRKFKIT------KEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSA
 |||||.| || ..||..|||      ||.|.| .  ||.  |. |||| ..      .||.|| .. . | |||| ||| |.   |.....|...    
tivmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqs

FGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVD
 ||..||||||||||||||.| ..|. .|    ||.|.  ...|. | .|.||. ||.||.|.. .
agpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlle

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 875-1135 1.2e-77 255.9 In-house 20-278 (315) alignment
Range on Protein: 875-1135
Range on HMM: 20-278/315.0
NDAGFKFSEEYEKVSAvGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSH
  .   | ..|| .   |  |  | .   ||. |||| ||.|||.|||.|  .. .|.|||.|||.|.||  .| |||.|||.... .||||. .|..  
astkngfkqdyesipg.gqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedig

VIVMLTQLVERGRTKCHRYWPGAqPEVYGEINVDMLSETEKSDWIVRKFKITKEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAFGPVIV
 |||||.|||. . |. .|||     .||.| | . ||  .... || . .. ... |..  ... |||| |||  . | ....| |.    .. |...|
kivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivv

HCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDA
|||||||||||||.| ..|....  . .|.. .   .|| | .|.|.  || ||..|....
hcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 878-1138 4.8e-95 312.9 In-house 14-278 (281) alignment
Range on Protein: 878-1138
Range on HMM: 14-278/281.0
GFKFSEEYEKVSAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIV
   | |||||..|.|.|..  ||  .||. ||||.|| |||..|||..  ...  .||||||..|||.  ..|||||||.|.....||.| |||. ..||
naGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaiv

MLTQLVERGRTKCHRYWPGAQ-PEVYGEINVDMLSETEKSDWIVRKFKI-TKEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAF-GPVIV
|.|. .| |. |||||||  .    ||.. | ...|.||. .| ||||. ...  .|.... ....|||||||...   |.| .||... ..    |...
mvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvi

HCSAGVGRTGTFIALGTLLQHI-KDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKS
|||||||||||.||| .|.... ...  .|.  .  |.|..|| |.||  || |..||..|| . 
hCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 878-1137 9.8e-42 137.8 In-house 5-260 (267) alignment
Range on Protein: 878-1137
Range on HMM: 5-260/267.0
GFKFSEEYEKVSAVGLDHSK-DASLLPENRAKNRYTNILAYDHSRVKLESIDDEpgsdYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVI
  .. .|.|..  .  ..|.   |.  .|...||. . | ||..|| |   ..|    |||| |. ||. ..|.|.||.||  |  ||. .  .|.  ||
eceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvi

VMLTQLverGRTKCHRYWPGA--QPEVYGEINVDMLSETEKSDWIVRKFKIT-KEKRSRTITHYQFVSWPdhgVPDEAGPALDFVREV--HEVASSAFGP
|.||.    .  . ...||    | . | .. |.   | |. |. .  ...  |.. .. .| | .  |    .  .  | |  .  .  ..    .  |
vlltkv...ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwn...intnnkpylkplfgilaknqlengnrP

VIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACK
..|.||.||||.|||. . . |. .|  . .|.| .  ..|. |  ...|  .|..||. ...  .
lvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyae

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 879-1132 2.7e-18 60.6 In-house 22-275 (303) alignment
Range on Protein: 879-1132
Range on HMM: 22-275/303.0
FKFSEEYEKVSAVGLDHSKDaSLLPENRAKNRYTNILAYDHSRVKLEsiDdepgSDYINANYIPGYRMRRAyIATQGPLPSTFDDFWRMTWEQNSHVIVM
    .|.|||..    .      . .|  |||.....  |||.|||   |    | || |.|.     ..| | || ||. |  |||.|  ||. .....
niavnefekvvsylppsvsk.nqfvknmdknrfvdvicldhskvkls..d....ssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvll

LTQLVERGRTKCHRYWPGAQPEVYGE---INVDMLSETEKSD-WIVRKFKITKEKRSRTITHYQFVSWPDHGVPDEAGPalDFVREVHEVASS-----AF
|    |  .   .  .|  |  .  |   | |  . . | .| | ..   ... .    .  ... .||   .| .. |   ||... .. |        
lltdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgsp..kfvkqiwqlqsvlrkysds

GPVIVHCSAGVGRTGTFIALGTLLQHI-KDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAM
 | .    .|.||.|||  . |    . ..   .||      .|. | | .|   |. ...  .
tptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytll

0047943 (Phosphotyrosine protein) phosphatases II 880-1134 1e-96 318.8 In-house 13-270 (273) alignment
Range on Protein: 880-1134
Range on HMM: 13-270/273.0
KFSEEYEKVSAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLesidDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVML
.. ||.|..  .  .... ..|||||. ||||..||.||||||||    ...|||||||.|..||.. |..||||||||.|..||||| ||||..|||||
llleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmL

TQLVERGRTKCHRYWPGAQ---PEVYGEINVDMLSETEKSDWIVRKFKITK--EKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASS--AFGPV
|.|||.|| ||..|||  .   ...||.. | .|||..|.|..||....|.   . |||.||... .|||||||.   . |.|...|... ..    |||
telvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpv

IVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVD
.|||||||||||||||| .||.... .  ||.. .   .|..| .|.||. ||.|...|...
vVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle

0036941 (Phosphotyrosine protein) phosphatases II 880-1137 1.7e-96 318.3 In-house 14-278 (297) alignment
Range on Protein: 880-1137
Range on HMM: 14-278/297.0
KFSEEYEKVSAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLesidDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVML
....|.|..  . |. |....|||||. ||||..||.|||.||||    |..|||||||.|..||.  |..||||||||.|..||||| ||||..|||||
lllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvml

TQLVERGRTKCHRYWPGA--QPEVYGEINVDMLSETE--KSDWIVRKFKITK--EKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASS--AFGP
|.|||.|| ||..|||    .. .||.. | .||...  ..|...|....|.  .. |||.||... .|||||||. . . |||...|..| .     ||
telvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggp

VIVHCSAGVGRTGTFIALGTLLQHIK---DHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACK
|.|||||||||.|||||. ..|| ..    .  ||.. .  ..|..|....||. ||.|.. |. . .|
vlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellk

DSPc_SM00195 880-1136 4.3e-94 310.1 In-house 1-262 (263) alignment
Range on Protein: 880-1136
Range on HMM: 1-262/263.0
KFSEEYEKVSAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVML
|..||.||. .   ..... .  ..|..||||.||| |||.||||.......|||||||||| |.. ...|||||||||||..||||| ||.....||||
klkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

TQLVERGRTKCHRYWPGA--QPEVYGEINVDMLSETEKS-DWIVRKFKITKEK--RSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAFGPVIV
|. .|.|..||.||||    ..|..|.|.| . ....|. ..|.|....|||.   .|..|.||. .||||||||.. . |...|.|..  |.  ||..|
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDAC
||||||||||||... ..|....... ||.| . .|.|..| .|.||. || ||..|.....
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 880-1136 4.3e-94 310.1 In-house 1-262 (263) alignment
Range on Protein: 880-1136
Range on HMM: 1-262/263.0
KFSEEYEKVSAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVML
|..||.||. .   ..... .  ..|..||||.||| |||.||||.......|||||||||| |.. ...|||||||||||..||||| ||.....||||
klkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

TQLVERGRTKCHRYWPGA--QPEVYGEINVDMLSETEKS-DWIVRKFKITKEK--RSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAFGPVIV
|. .|.|..||.||||    ..|..|.|.| . ....|. ..|.|....|||.   .|..|.||. .||||||||.. . |...|.|..  |.  ||..|
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDAC
||||||||||||... ..|....... ||.| . .|.|..| .|.||. || ||..|.....
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_PTPN6_pd Subfamily PTPN6 880-1134 3e-86 284.2 In-house 27-295 (306) alignment
Range on Protein: 880-1134
Range on HMM: 27-295/306.0
KFSEEYEKVSAV--GLDHSKDASLLPENRAKNRYTNILAYDHSRVKLEsIDDEPGSDYINANYIPGY--RMRRAYIATQGPLPSTFDDFWRMTWEQNSHV
 |.||.|...       .|.. .  |||. |||| ||| .||.||.|.  .. ||||||||||| .     ...|||||| |..|  ||||| |..||.|
gfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrv

IVMLTQLVERGRTKCHRYWPGA-QPEVYGEINVDMLSETEKSDWIVRKFKIT---KEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAF--
|||.|. ||||. || |||| . . | ||.|.| ..||....|.|.|.....   |.|..|.. .|.| |||||||| . |  |||...|.. ...    
ivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleea

--GPVIVHCSAGVGRTGTFIALGTLLQHIKDHDW---VDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVD
  ||..||||||.||||||| . .||. |. . .   .|.  |   .|..|. ..||| || |..||.  
eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 880-1139 6.2e-69 227.6 In-house 24-291 (325) alignment
Range on Protein: 880-1139
Range on HMM: 24-291/325.0
KFSEEYEKVSAVGlDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVML
 |. |.. . ...   .| .. .|||.||||. |..|.|.||| ||. .|.| ||||||.|.  .. .  ..|.| ||..| .|.||.  . .. |.|.|
gfahefgllpsdd.giakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvl

TQLvERGRTKCHRYWPGA--QPEVYGEINVDMLSETEKSDWIVRKFKITKEKRS--RTITHYQFVSWPDHGVPDEA---GPALDFVREVHEVAS---SAF
 .| . |  .|  |||    .   .| ..| . .  | ||.. |.... . |.   |..  .|. ||.| ||.       . |. | .|.|       | 
nel.dlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkas

GPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKSS
.|..|||||||||||.||.| ..|... ..  ||.||    .|..|  |..|  ||..|..|.|.|  |.
tpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsg

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 880-1132 2.3e-51 169.3 In-house 16-289 (301) alignment
Range on Protein: 880-1132
Range on HMM: 16-289/301.0
KFSEEYEKVSAvGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESI--DDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIV
||.|.|....  | |.| . .|  ||.| ||. ||  ||. |. |.     |    .||||.|| ||. ....||.|||. .|  ||||. |..    ||
kfeeqykelke.gedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsiv

MLTQLVERGRTKCHRYWPGA--QPEVYGEINVDMLSETEKSD-----------------WIVRKFKITKEKRSRTITHYQFVSWPDHGVPDEAGPALDFV
|.|.| |. ..||..||| .  . | .|...| . .|.   |                  | ||||....| |.... .| ..||..||  |    |  .
mvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqvi

RE-VHEVASSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAM
 . .|   .   |||.||||..|.|.|.....   |   |    ||.|..   .|. .  ...|  ||..|....
ddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvi

0046845 (Phosphotyrosine protein) phosphatases II 881-1138 4.9e-99 326.5 In-house 2-276 (284) alignment
Range on Protein: 881-1138
Range on HMM: 2-276/284.0
FSEEYEKVSAVGLDH--SKDASLLPENRAKNRYTNILAYDHSRVKLESIDDE-PGSDYINANYIPGY-----RMRRAYIATQGPLPSTFDDFWRMTWEQN
. ||.|..  .  ..  | ...|||||. ||||..||.|||||||| |.|.. ..||||||.|..||     . ....||||||||.|..||||| ||||
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

SHVIVMLTQLVERGRTKCHRYWPGAQ-PEVYGEINVDMLSETEKSDWIVRKFKITK---EKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVAS--
..||||||.|||.||.||..|||  . . .||.. | .|||..|.|..||....|.   .. |||.||... ||||||||... . |.|.|.|.|. .  
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

SAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHD---WVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKS
.  ||..|||||||||||||||| .||.... ..    ||.... . .|..|..|.||. ||.|...|.....|.
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl

subfamily_PTPN9_pd Subfamily PTPN9 881-1136 2e-85 281.4 In-house 18-290 (297) alignment
Range on Protein: 881-1136
Range on HMM: 18-290/297.0
FSEEYEKVSAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLT
 |.||... .       .|| |. |  |||||..| ||..||.|...|... |||||||.. ||. ..|.|||||||. |..||||| |||.  |||| |
lskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmtt

QLVERGRTKCHRYWPG--AQPEVYGEINVDMLSETEKSDWIVRKFKIT--KEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSA---F----
..||||| || .|||    . . .|...|  ..  |..|. ||...|.  |...||..||.||.||||.|||..|   ||....| |  ..|   .    
rvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdew

------GPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDAC
       |..||||||.|||||||.|   |..... . ||..   . .|. | ..|||. ||.| ..|...  
kghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya

subfamily_PTPN14_pd Subfamily PTPN14 881-1139 2.2e-61 202.5 In-house 25-299 (300) alignment
Range on Protein: 881-1139
Range on HMM: 25-299/300.0
FSEEYEKVSAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEpGSDYINANYIPG--YRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVM
   |||...   .|   ... ||||  |||. ..| |...||.| .  ..  ..||||  |       .| ||..||||. |  |||.| |||. ..|||
vfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivm

LTQLVERGRTKCHRYWPGA----QPEVYGEINVDMLSETEKSDWIVRKFKIT--KEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVAS---SAF
||.  | |..|...|.|      .   .|. .|     .. .  | ...|.     |. ||. | |.. |||||||..  . |....||. |     |  
lteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnsev

------GPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKSS
       ||.|||||||||||  |    |.. ..  . .|.    . .|. | ...||  || |..|...   |.|
eskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkns

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 881-1134 5.9e-57 187.7 In-house 11-264 (283) alignment
Range on Protein: 881-1134
Range on HMM: 11-264/283.0
FSEEYEKVSAVGLDHSKDASllPENRAKNRYTNILAYDHSRVKLESIDDepgsDYINANYIP---GYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIV
| | ....|   ||   ...   ||. |||. .|...|  ||.|.|       ||||| .||    |.  . ||..|.||  |  |||.| ....   ||
frevlkrlsvpdldadiasa..denkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaiv

MLTQLVERGRTKCHRYWPGAQPEVYGEINVDMLSETEKSDWIVRKFKITKE---KRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAFGPVIV
|||.| |  | || .|||    | |||  | .  || .  .|.... . ..   | .  ..|||.. | . |        . | . .     |  ||..|
mltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivv

HCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVD
|||.|.|||..|||. . ..... .  ||.|     ||..|  ..||  || ..|.....
hCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle

subfamily_CG7180_pd Subfamily CG7180 881-1135 3.7e-56 184.9 In-house 19-289 (296) alignment
Range on Protein: 881-1135
Range on HMM: 19-289/296.0
FSEEYEKVSAVGLDHSKDaSLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLT
.  |..... .  .. .   |  ||| |||. ... ||. || ||..| |  |||||| |. ..   ..|| |..|  .| |.|||. ...... .|.||
yklelkltprleigdCag.glrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLt

QLVERGRtKCHRYWPGAQPEVYGEINVDMLSETEKSDWIVRKFKITKE------------KRSRTITHYQFVSWPD-HGVPDEAGPALDFVREVHEVASS
.  .  . ... |||  . | |||| |....| . ..   |.||.||.               |.....|.  |.  . ||  .   ....| |. .   
ktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrek

A-----FGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDA
.      |||.|..| |..|.| ..|.   |. .. .. ||.|. .  .|..|......  .| .|   . .|
vdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 881-1135 3.1e-31 103.2 In-house 21-275 (312) alignment
Range on Protein: 881-1135
Range on HMM: 21-275/312.0
FSEEYEKVSAVGLDHSKDASLlpENRAKNRYTNILAYDHSRVKLESidDEpgSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLT
.. ||  |  .  |    | |    .  ||| ||  .|  |  |    ||    || ||..        ...||||| .|   ||...    |  |..|.
ltkeykavgnivsdsectafl..kfkdlnrypniqcwdrgrftlag..de..nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillc

QLVERGRTKCHRYWPGA-------QPEVYGEINVDMLSETEKSDWIV---RKFKITKEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEvassAFG
 .|| |  || .|           .  || |   ..       | |     |  .    .   . |||. ||||||.||    || ..  |.        
gfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkk....dkk

PVIVHCSAGVGRTGTFIALGTL---LQHIKDHDWVDLFGLaseMRQHRNHMIQTEPQYVFIHKAMVDA
||| |||||||||||.. . ..   |.| .  .  | | |   .|. |   ... ||||.  ..... 
pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvl...lrkdrarsvrvfpqyvyalrcvlef

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 881-1140 2.9e-18 60.3 In-house 28-289 (302) alignment
Range on Protein: 881-1140
Range on HMM: 28-289/302.0
FSEEYEKVSAVGLDHSKdASLLPENRAKNRYTNILAYDHSRVKLESIDDepgsDYINANYIPGYRMRRAYIATQGPLPSTF---DDFWRMTWEQNSHVIV
  .|..|....  |  |  ..  .| .||. ... ..|. .||||   |    .|.||  .    ..|  | .| |  ..    ..|||| ....   .|
vkkefkkidtmkvdlek.Ckafkknlkknqsedvpildsnlvkleaepd....syvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvv

MLTQLVERGRtKCHRYWP--GAQPEVYGEINVDMLSeTEKSDWIVRKFKI--TKEKRSR--TITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAFGP
.| .  |  .   . ..|    . . ||.. |      ||..  . .. |    |  |    .. | .  |... ||.. . .   . .|..  ..|  .
ilvgeeelkk.tlselfpkksgdykeygkmfvNnrk.VekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikaden

VIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKSSM
...    |.|| |.|..| . ........ .    ..  .|. | .....  |||... |..   |  .
tvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkkv

subfamily_PTPN13_pd Subfamily PTPN13 882-1137 2.2e-72 238.6 In-house 14-270 (273) alignment
Range on Protein: 882-1137
Range on HMM: 14-270/273.0
SEEYEKVSAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLEsidDEPGsdYINANYI--PGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVML
.||....  .    . . .   ||..|||| |.| ||..||||.   || |  ||||..|  |    .  |||.||||| | .|||.| |||...||.|.
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklg...degg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv

TQLVERGRTKCHRYWPGAQP---EVYGEINVDMLSETEKSDWIVRKFKITKE--KRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASsAFGPVIV
|. .|.|. |||||||  .     |.. ..|..|  ...... ||......   ..|| ..| .||.||||||| .| . | ||.|| ....   ||..|
tlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivv

HCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACK
|||||.||.||.|.. ..|. |.    .|.  .  ..|. |. ..||. ||.|..||.... |
hcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk

subfamily_PTPN1_pd Subfamily PTPN1 883-1138 1.3e-67 222.5 In-house 10-273 (290) alignment
Range on Protein: 883-1138
Range on HMM: 10-273/290.0
EEYEKVSAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDepgsDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQL
| |....    |..  .. |||||..||| ..  |||||.|||. |     |||||. .   ...| || ||||||.| | ||.| |||.|. .||| ..
eiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkv

VERGRTKCHRYWPGAQP--EVYGE---INVDMLSETEKSDWIVRKFKITK--EKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVA--SSAFGPVI
||....||..|||  .   |.  |   ..|...|| .|| ..||......   ...|.|.|. ...||| |||.  .  |.|. .| |    ||  ||..
vekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpav

VHCSAGVGRTGTFIALGTLLQHIKDHDW---VDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKS
.|||||.||.|||. . |.| .|...|    ||.     |.|..|  .|||  |  | . |...  | 
ihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakv

subfamily_CG42327_pd Subfamily CG42327 883-1064 5e-33 109.1 In-house 9-193 (319) alignment
Range on Protein: 883-1064
Range on HMM: 9-193/319.0
EEYEKVSavGLDHSKDaSLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMR-RAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQ
||....    |  . |  . .  . |.|. |..   ..|| |..| |.. . |..|.|. ||.     |||.| .| ..  ||||. |||.| ||| ||.
eefrdlP..qliarad.evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltd

LVERGRTKCHRYWPGA----QPEVYGEINVDMLSETEKSDWIVRKFKIT--KEKRSRTITHYQFvSWPDHGVPDEAGPALDFVREVHEV
| | |  .| .|.|      . ..||.| | .     |  ...  . .   ... || .||| .  |.. .|| |  . .  . ||.. 
lselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 883-944 3.8e-09 30.5 In-house 17-77 (244) alignment
Range on Protein: 883-944
Range on HMM: 17-77/244.0
EEYEKVSAVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDEpGSDYINANYIPGY
||.  .|    .  .  ..|  | .|||| ||| .|..|| | |   | |||||||||| | 
eefvglsdhtreflqtnavlsanatknryinilpfdetrvilssskke.gsdyinanyiqgs

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 885-1158 1.2e-79 262.8 In-house 4-272 (284) alignment
Range on Protein: 885-1158
Range on HMM: 4-272/284.0
YEKVSAVGLDHS-KDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTqlv
. ... .| . . .  . |..|. |||...|||.|...|||| .. | .|||||| .| ||. .  ||||||||. | .||||| ||.|.  ||.||   
frracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt...

ergRTKCHRYWPGAQPEVYGEINVDMLSETEKSDWIVRKFKITK---EKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAF--GPVIVHCSA
   . || .|||    . ... .|.. | .| ....||......   ||  |.|. . |  |||.|||| . . . .|. |. . |      ...|||||
...kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsa

GVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACkssmsKFGGGIKVLPSFPIYSN
||||||..|.| .||. .|. . ||.. .  ..|| ||...|   || ||. |...        ||    .|| || | .
gvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh.....lfghsdvalpdfpayle

subfamily_egg_pd Subfamily egg 887-1133 1.9e-28 94.0 In-house 26-267 (307) alignment
Range on Protein: 887-1133
Range on HMM: 26-267/307.0
KVSAVGLDHSKDAsllpENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERg
 |  . | .. ..    .|. | |   .   | ||||||        |.| ||.. |  .   .| .| ||  | |||||| .... . |||||  .|  
svdeislttaasd....nnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes.

rTKCHRYWPGAQPE--VY--GEINVDMLSETEKSDWIV--RKFKI-TKEKRSRTITHYQFvswpDHGVPDEAGPALDFVREVHEVASsafgPVIVHCSAG
  .|. ||| |. .  |.  | .... |   .|.| .    |.|.   ..  | . |.|     |     .    |  .| . ...     ||.|..  |
.erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg....dvnnssdvysplrvlrklrnlsk....pvvvqdilG

VGRTGTFIALGTLLQHIKDHDW-VDLFG-LASEMRQHRNHMIQTEPQYVFIHKAMV
| ...|..|. . | ..        |       .|..|.  ...  .|.|... ..
vskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 888-1128 2.6e-36 119.9 In-house 34-273 (301) alignment
Range on Protein: 888-1128
Range on HMM: 34-273/301.0
VSAVGLDHS-KDASLLPENraKNRYTNILAYDHSRVklESIDDEPgSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERG
|...  ||  .  . ||..  |.|| ..    .. |  | |.|      | ||.||     . .|||||||..| .||| |    . . ||||.| ||. 
vttidkdhitesyaylpkd..khryptvPckPstav..evivdGk.rvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekl

RTKCHRYWPGAQPEVY--GEINVDMLSE--TEKSDWIVRKFKI---TKEKRSRTITHYQFVSWPDHGVPDEAGPALDFVrevhEVASSAFGPVIVHCSAG
 .||. | |   .|    |  .. . ..    . . . |....   |..  .||.||||...|.|.|||       |..    |..  .  |..||||||
eekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlm....elvkksekPivvhcsaG

VGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFI
.||. .||.   | .... .  ..|     ..|.|| . .||. |  ..
iGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywm

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 890-1137 1e-79 262.5 In-house 13-269 (274) alignment
Range on Protein: 890-1137
Range on HMM: 13-269/274.0
AVGLDHSKDASLLPENRAKNRYTNILAYDHSRVKLESI-DDEPGSDYINANYIPGYRM-RRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGR
 . |.....   .. .  ||||..||  ..||| |||   ... |.||||||| ||.   .||.|||||||.| .||||| ......||||||.| |. .
elPlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeane

TKCHRYWPGAQP----EVYGEINVDMLSETEKSDWIVRKFKITKEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASS---AFGPVIVHCSAGV
.||..|.| |.     | ||.... . . .|. |. |||. . . .|.|...|| . .|||| .||.| . ||.|.||.| ...     .||.||||||.
qkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGi

GRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACK
|||| |||    .......  ||.... ...|..|  |.||. || .||.|..   |
GrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk

subfamily_PTPN3_pd Subfamily PTPN3 894-1137 1.1e-78 259.0 In-house 30-276 (280) alignment
Range on Protein: 894-1137
Range on HMM: 30-276/280.0
DHSKDASLLPENRAKNRYTNILAYDHSRVKLESIDDepgsDYINANY----IPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTK
. . .|. .||| .|||| .||.||. ||||.. .     |||||||    ||.  .   ||||||||..|  |||.|.|||.|..|||||.||||||.|
glaisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvk

CHRYWPGAQPEV-YGEINVDMLSETEKSDWIVRKFKITKEK--RSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAFGPVIVHCSAGVGRTGTF
||.|||  . |. |||..| . .| |.. ...|.. .....  ..|.|.. |...||||||||..   |.||..|... |..  ||.||||||.|||| .
ChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvl

IALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACK
|.| | |. |  .. |    . ..||. |  ..||. || |. .|.. . .
illetalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvye

0049772 (Phosphotyrosine protein) phosphatases II 894-1140 4.4e-50 166.5 In-house 35-284 (314) alignment
Range on Protein: 894-1140
Range on HMM: 35-284/314.0
DHSKDASLLPENRAKNRYTNILAYDhSRVKLeSIDDEPGSDYINANYIPGYrmrRAYIATQGPLPSTFDDF----------WRMT--WEQNSHVIVM---
...  .. |..|| ||||..|| .| .||.| .  .  |||||||.|. |.   ...|||||||. |..||          |||.  ...|...|||   
eltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrd

------------------LTQLVERGrtkchrywpgaqpevygeinvD--------MLSeteksdwivrkfKIT--KEKRSRTITHYQFVSWPDHGVPdE
                  |..| ..|                     .        .|             ...  .|. .|.. .|  . .||...|  
evladelsrLdaAlgKtpllildgng.....................neptaadlellk............eelydpelferlgikylripvpDgsap.l

AGPALDFVREVHEVasSAFGPVIVHCSAGVGRTGTFIALGTLLQHIkdhdWVDLFGLASEMRQHRN-----HMIQTEPQYVFIHKAMVDACKSSM
    ..|.. ..|.  .. |||.|||.||.||||||.... |. .     .|.|    ...|. |      ..|..  ||.||..|. ...|  .
ledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylkflk

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 894-1134 1e-39 131.0 In-house 41-288 (310) alignment
Range on Protein: 894-1134
Range on HMM: 41-288/310.0
DHSKDASLLPENRAKNRYTNILAYDHSRVKLEsIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRY
| |       ..  ||||....  | |||||. ||     ||| |||.    .| ..| .||||  |  ||||| ... .  |..| . .| || ||  |
dssltyeaykkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgy

WPGA-QPEVYGEINVDMLSETEKSDWIVrKFKIT--------KE----KRSRTITHYQFVSWPDHGVPDEAGPALDfvreVHEVASSAFGPVIVHCSAGV
||     | || | |  |||. .   |. .. .|         |     .   ..  ..  ||| |||||   ..        .|    ||..||||||.
wpslgvtetygcirvtnlsesseefeic.nlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp....qrllaqvrhgpcvvhcsagk

GRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVD
.|... .||   .....  . ||.  . .|....|   |||| ||..|.. .. 
drlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvrii

subfamily_PTPN23_pd Subfamily PTPN23 895-1144 7.4e-63 207.0 In-house 31-288 (288) alignment
Range on Protein: 895-1144
Range on HMM: 31-288/288.0
HSKDASL--LPENRAKNRYTNILAYDHSRVKLESIDDepgsDYINANYIPGYR-MRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCH
.... |.     .  |||...|| |||.||||..  |    ||||| .. .   .   .||||.||.||  |||.| .|| | |||||..  |.|..|..
earkrsiaiaklyseknrsrdilPyDhnRvklrgskD....DYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvd

RYWPGA--QPEVYGEINVDMLSETEKSDWIVRKFKITKEK--RSRTITHYQFVSWPDHGVPDEAGPALDFVREVHE----VASSAFGPVIVHCSAGVGRT
|||| .  .....|...| . |..| . .. |..|.. ..  . ....| |. |||..|||.  .  |.|. ||..    |   .  |..||||||||||
rYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRt

GTFIALGTLLQHIKDHD-WVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKSSMSKFG
|.|  . . .. .. ..  .|.  . | .|. | .|.|.. |. |  .|.. | .  . | |
gvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvldkrG

subfamily_PTPN12_pd Subfamily PTPN12 897-1141 2.4e-83 274.4 In-house 32-282 (290) alignment
Range on Protein: 897-1141
Range on HMM: 32-282/290.0
KDASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPG
..|.  .||..|||| .|| ||.|||.|. |..|.||||||||.| |   . .|||.||||| | |||||| ||.| ...||. ..|| |..||.|||| 
teagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpe

A-QPE-VYGEINVDMLSETEKS-DWIVRKFKITKEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAFGPVIVHCSAGVGRTGTFIALGTLL
  . |  .||..|.. .|   . |...| .|....| ||... ... .|||||||  | . |.....|.|. .|   |..|||||||||||| ||.    
egeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvr

QHIK---DHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKSSMS
. .|     . .|.| |  |.|..|. ..||. ||....||... ......
ellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkele

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 897-1137 1.3e-47 156.9 In-house 46-284 (290) alignment
Range on Protein: 897-1137
Range on HMM: 46-284/290.0
KDASLLPENR--AKNRYTNILAYDHSRVKLEsiDDEPGsDYINANYIPGyrMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYW
 . ... .|    |||| ..   | .|| |.  |  .| ||. |||. |  ..  .| |||.| .|  |.|||  ...  .|||| .|.| |..||..|.
lerkifdkntefkknrykdvvcndktrvilk..dGydG.dyvhanyvkG..lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyy

PGAQPEV--YGEINVDMLSETEKSDWIVRKFKITKE---KRSRTITHYQFVSWPDHGVPDEAgpaLDFVREVHEVAsSAFGPVIVHCSAGVGRTGTFIAL
|  . ||  .||| |    |..| . |..|    ..    ..  . |.. .||||. |.  .   | ..| .. .   | |||.||||||.||||||.|.
pekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalst...lallrtlrilr.kasGpvvvhcsaGiGrtGtfvai

GTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACK
 . || . |   .|| .|   .|. |   .| . ||. . ....|  |
evglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGk

0040439 (Phosphotyrosine protein) phosphatases II 898-1135 9.1e-88 289.3 In-house 4-245 (249) alignment
Range on Protein: 898-1135
Range on HMM: 4-245/249.0
DASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGA
. .|||||. ||||..||.||||||||..... ..||||||.||.||.. |..||||||||.|..||||| ||....||||||.|||.|| ||..|||  
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplg

QPEVYGEINVDMLSETEKSDWIVRKFKIT--KEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASS--AFGPVIVHCSAGVGRTGTFIALGTLL
.. .||.. | .||...|.|..||....|  ... |||..|.|...|||||||.   ..|||...|... ..    |||.|||||||||||||||. ..|
gsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylml

QHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDA
.... .  |||.   ...|..|....|.. ||.|...|. . 
eqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel

0042113 (Phosphotyrosine protein) phosphatases II 899-1134 2.3e-87 287.7 In-house 3-241 (245) alignment
Range on Protein: 899-1134
Range on HMM: 3-241/245.0
ASLLPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQ
 .|||||. ||||..||.|||.|||| ... ...||||||.|..|||. . .||||||||.|..||||| ||.....|||||...|.|| ||..|||  .
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplge

PEVYGEINVDMLSETEKSDWIVRKFKIT--KEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVAS-SAFGPVIVHCSAGVGRTGTFIALGTLLQH
. .||.. | .|||. ..|..||....|  ... ||...||....||||||||     |||...|... . .. |||.|||||||||||||||. ..|..
sltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleq

IKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVD
.. .  |.|.    |.|..| ...||. ||.|...|. .
lekelgvsleeavkelrsqRpgavqtpsqyrflyealle

0037934 (Phosphotyrosine protein) phosphatases II 899-1133 3.5e-81 267.6 In-house 4-239 (243) alignment
Range on Protein: 899-1133
Range on HMM: 4-239/243.0
ASLLPENRAKNRYTNILAYDHSRVKLesiddePGSDYINANYIPGYRmrRaYIATQGPLPSTFDD----FWRMTWEQNSHVIVMLTQLVERGRTKCHRYW
 .|||||. ||||..||.||||||||      .||||||||.|....  | .||||||||.|..|    |||| ||....||||||.|||.|| ||..||
iallpenlsknrysdilpydhsrvkl......egsdyinanliyvtp..r.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PgaQPEVYGEINVDMLSETEKSDWIVRKFKITK---EKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEV--------ASSAFGPVIVHCSAGVGRT
|  ....||.. | .|||....|..||.....    .. .|...||....||||||||.  . |||..||.|.        | .  |||.||||||||||
p..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRt

GTFIALGTLLQHIkdhDwVDLFGLASEMRQHRNH-MIQTEPQYVFIHKAMV
||.||. ..|...   . |||.    ..|..|.. ..||. ||.|...|. 
Gtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeall

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 899-1133 2.5e-22 74.4 In-house 13-256 (290) alignment
Range on Protein: 899-1133
Range on HMM: 13-256/290.0
ASLLPENRAKNRYTNILAYdHSRVKLESIDDEPGSDYINANYIPgYRMRRAYIATQGPLP-------STFDDFWRMTWEQNSHVIVMLTQLVERGRT---
. .. ..  ..|... |.  ..|| |.       .||| ||..  .    . |.|| |.        ||  .|| |  . ... .||| .  |. .    
tdyvkkhemdqRlevpLve.atrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantsl

-KCHRYWPGAQPE--VYGEINVDMLSETEKSDWIVRKFKITKEK-RSRTITHYQFVSWPDHGVPDEAGPALDFVREVHevASSAfgPVIVHCSAGVGRTG
  | .| | .  |   .. ..|   |  .. | ..|.  .. .. .  |.||.....| .  |...   .|. .. |.  || .  ||||||  |. |  
faCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk..askt..pvivHcvdGiSrsA

TFIALGTLLQHIK-DHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMV
.. |.    | |   .. | |  . ...|..|...|... .. |.  ..|
alaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 902-982 2.6e-10 33.5 In-house 24-77 (169) alignment
Range on Protein: 902-982
Range on HMM: 24-77/169.0
LPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINAnyipgyrmrrayiatqgplpstfddfwRMTWEQNSHVIVMLTQL
|  | .||| .  ||  | ||||. . .. |||||||                           || || |. |||.| . 
ltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdt

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 902-982 3.1e-10 33.1 In-house 23-76 (169) alignment
Range on Protein: 902-982
Range on HMM: 23-76/169.0
LPENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINAnyipgyrmrrayiatqgplpstfddfwRMTWEQNSHVIVMLTQL
|  | .||| .  ||  | ||||. . .. |||||||                           || || |. |||.| . 
ltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdt

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 903-1138 1.4e-85 281.5 In-house 7-244 (250) alignment
Range on Protein: 903-1138
Range on HMM: 7-244/250.0
PENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTkCHRYWPGAQPEVY
|.|. ||||..|.|.|.||| ||. . .  |||||| .. ||. |.|.|||||||..|. ||||| .|..| .|||||.|.| ..| .|.|||  ..| |
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaeky

GEINVDMLSETEKSDWIVRKFKITKEKRSRT--ITHYQFVSWPDHGVPDEAGPALDFVREVHEVASS-AFGPVIVHCSAGVGRTGTFIALGTLLQHIKDH
|.. |..||. |..|...||.|..|.|..    . ...||.||| |||..|  .|.....|.        .||||.|||||||.|.|||. ..|...|  
GdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkke

DWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKS
  ||.| .   .|..| |..... ||||.....  | .|
kvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 903-1138 1.4e-73 242.6 In-house 46-286 (297) alignment
Range on Protein: 903-1138
Range on HMM: 46-286/297.0
PENR---AKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRMrrAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRtKCHRYWPGAQP
 |..    |.||.||| || |||||....|.| |||.|| ...|..    .|.|| | ..| .|||.| ....  .||||... || . || |||.    
aekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgv

EVYGEINVDMLSETEKSDWIVRKFKITKEK--RSRTITHYQFVSWPDHGVPD--EAGPALDFVREVHEVASSAF-GPVIVHCSAGVGRTGTFIALGTLLQ
  .|.. | .|| .|..  | |....||.|    | .  ||||.|||. |.   .|   |... ||... |.   ||..|||.||||||| ....   . 
ttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvva

HIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKS
..|... ||.||| . .||.| ...||. || |...|...|  |
eakrekevdifglvkklrqerpylvqtkeqykfvyvavlealls

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 903-1133 3.1e-67 221.3 In-house 1-236 (237) alignment
Range on Protein: 903-1133
Range on HMM: 1-236/237.0
PENRAKNRYTNILAYDHSRVKLESIDDEpgSDYINANYIPGYR-MRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPG-AQPE
.||..|||| || ||||||| |.    .  ||||||.|. |.    . |||.|||| |. ||||.| |...  |||||| |.|. . |||.|||   ||.
senkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpa

VYGEINVDMLSETEKSDWIVRKFKITKE---KRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASS--AFGPVIVHCSAGVGRTGTFIALGTLLQH
 || . | .  . | ||. || . ..|.   |  | |  ||| ||||.|||...   | | ... . .      || |.|||||||||| |. . ..|..
aygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq

IKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMV
 |..  ||..     . . | ..|||. ||||||....
akekkvvdiynyvysieedrpyiiqtkdqyvfihqtil

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 903-1135 6.6e-45 147.9 In-house 35-268 (281) alignment
Range on Protein: 903-1135
Range on HMM: 35-268/281.0
PENRAKNRYTNILAYDHSRVKLES-IDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQP--
| |  ||||.|| . | |||.|.  . ..  .||| ||||    ..| || ||||   |  ||||| |..|.  |||| |..|  | ||  |.|      
pvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcc

EVYGEINVDMLSETEKSDWIVRKFKITKEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHevASSAfgPVIVHCSAGVGRTGTFIALGTLLQHIKDH
  . .. |.    | .   .  ..... |  .| |||. .  |||  ||. .   |  .|...  | |.  | ..||||||||.||..|.   || |. |
lqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkir..arst..ppvihcsagvgrsgtlmaveialqsihsh

D-WVDLFGLASEMRQ-HRNHMIQTEPQYVFIHKAMVDA
    |.  . | .|   |   .||  ||..| | ..| 
ftlpdikqivshlrvtgraasvqtlqqymliwkvlldf

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 904-1138 2.3e-71 234.9 In-house 19-266 (270) alignment
Range on Protein: 904-1138
Range on HMM: 19-266/270.0
ENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRM-RRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPE--
 ... |||..||   ..||.||...... . ||||||..|.   ...|||..||||.|  .|||| ||.... |||.|.|.|.||.|| ||||  . |  
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekv

--VYGEINVDMLSETEKSDWIVRKFKITKEKRSRTITHYQFVSWPDHGVPDEAG------PALDFVREVHEVASSA--FGPVIVHCSAGVGRTGTFIALG
   .|.|.|  |||. .. .|... .....  .| ..|.....||||||| |..        |  .|.|... ..    .|..||||||||||||.||| 
kledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialD

TLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKS
. .. .. .  ||.  . .|.|..|  ..|.  || |..||.|  .. 
iavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer

subfamily_ptpA1_pd Subfamily ptpA1 904-1096 5.5e-50 165.3 In-house 46-256 (418) alignment
Range on Protein: 904-1096
Range on HMM: 46-256/418.0
ENRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYRmRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWP----GAQ-
 | .||||||||  .|.||.|. |.|. |||||||||| |    . .|.|||||| |  ||||| ||.  ..||||..  |  | || ||||    | | 
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqf

------PEVYGEINVDMLSE--TEKSDWIVRKFKITKEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHE-----VAS-SAFGPVIVHCSAGVGRTG
       ||.|  .|...      . . | |. ..| |  .| ||.||.  |||| .|| . |  .... . .     . |     |.||||||||||||
siygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtg

TFIALGTLLQHI
|| .   .....
tfctavimmkkl

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 904-1132 1.8e-39 130.5 In-house 42-267 (288) alignment
Range on Protein: 904-1132
Range on HMM: 42-267/288.0
ENRAKNRYTNILAYDHSRVKLEsidDEPgSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPEV--
.| ...||.|.   | .||||.   |.|   ||.|| ..  . .|  | .| || .| . .|.|  |.. . ||||..|.|.|. |   |.|  . |   
anptrdryenlprcditrvkls...ddp.dfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

YGEINVDMLSETEKSDWIV--RKFKITKEKRSRT-ITHYQFVSWPDHGVPDEAGPALDFVREVhevaSSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKD
.| .  ..  . .  | .|    ..|.||   .  . .  .  |.|.|||..  . | ..  .     |   |..||.|||||||||.|     |. .. 
igrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlililialeslrl

HDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAM
.| . .  | ...|..| . |||| ||...|. .
ddflgirsllaklreerfkaiqtemqylyvhrcv

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 904-1137 1.4e-38 127.4 In-house 47-288 (305) alignment
Range on Protein: 904-1137
Range on HMM: 47-288/305.0
ENRAKNRYTNILAYDHSRVKLESiddEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPEVY-
... |||| ..   |. |||||.       .|| |||.      . .| || ||  |  ||| | .... . | || .|.|.|  ||. |..  . .|  
qeagknrykdvgcldnnrvkleg...pwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvle

-G----EINVDMLSE-----TEKSDWIVRKFKITKE---KRSRTITHYQFVSWPDHGVPDeagpALDFVREVHEVASSAFGPVIVHCSAGVGRTGTFIAL
       | | . |      .....  |.. ... |   ...| .||| .. ||| |||     |   . |. | | .. ||..||||||.||||. . |
feekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpa....adlailellekarpskgpivvhcsagigrtgsvvml

GTLLQHIKDHDWVDL-FGLASEMRQHRNHMIQTEPQYVFIHKAMVDACK
  .|. .   . ..    .   .|. ||  |||. ||.|.|. ... ..
eyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr

subfamily_eak_pd Subfamily eak 904-1139 1.2e-16 55.1 In-house 51-308 (332) alignment
Range on Protein: 904-1139
Range on HMM: 51-308/332.0
ENRAKNrYTNILAYDHSRVKLESIDDEPgSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPE--V
|.  .|   .|. ||.  |.| |   ..   ||||  .    . | || |  .  .    ||.|  ||.|  ||.| . || .  |  .|.|    |   
eavnrn.vvkivpydrylvrltssqlnr.lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelk

YGEINVDMLSETEKSDWIVRKFKITKEKRSRTITHYQFVSWPDHGVPDE------------AGpALDFVREVHEVASS----------AFGPvIVHCSAG
.| ..|.  .  ...   .|.....|   .  . ||..  | .  .|              .| .| ..    .. ||          .| | |. .. |
fGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedflalrkvmkevG.vlllivmksallsstlkkyihtppsfap.iiqsarG

VGRTGTFIALGTLLQHIkDHDWVDLFG---LASEMRQHRNHMIQTEPQYVFIHKAMVDACKSS
  |.|.|. .  |.. | |    .|.    |   ....|.| . .. |. ||.....|  .  
saraGvfvvidllirli.dnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrr

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 904-1028 2.5e-11 37.6 In-house 33-158 (332) alignment
Range on Protein: 904-1028
Range on HMM: 33-158/332.0
ENRAKNRYTNILAYDHSRVKLESIDDEpgSDYINANYIPGYRMRRAYIATQGPLPST-FDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRY--WPGAQPE
.|   ||   . ..|||||.|   | .   |. ||... ||  . ||| .| |.       ||||  |..  .|... .. |. . |.       | .  
nnmdmnriphlycfdhsrvelapqdgk..ddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapydisdrgfeks

VYGEINVDMLSETEKSDWIVRKFKITKE
.  |.    | | |    |.|||   |.
flhefgaksleecelkakicrkfwpekr

Y_phosphatase Protein-tyrosine phosphatase 905-1133 7.8e-86 282.7 Pfam-A 1-234 (235) alignment
Range on Protein: 905-1133
Range on HMM: 1-234/235.0
NRAKNRYTNILAYDHSRVKLesiDDEPG-SDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWP--GAQPEV
|. ||||..||.||..||||   ....| ||||||||. ||.  ...|||||||.||..||||| |.....||||||.|.|.||.||..|||    ... 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGEINVDML-SET-EKSDWIVRKFKITKEKRS---RTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAFGPVIVHCSAGVGRTGTFIALGTLLQHI
||.|.| .  .|. .......||....|.|..   |....... .|||||||... . ||..|.|..  ..  |||.|||||||||||||.|| .||...
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMV
.... ||.. . .|.|..|..|.|.. ||.|..||..
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 905-1133 7.8e-86 282.7 In-house 1-234 (235) alignment
Range on Protein: 905-1133
Range on HMM: 1-234/235.0
NRAKNRYTNILAYDHSRVKLesiDDEPG-SDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWP--GAQPEV
|. ||||..||.||..||||   ....| ||||||||. ||.  ...|||||||.||..||||| |.....||||||.|.|.||.||..|||    ... 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGEINVDML-SET-EKSDWIVRKFKITKEKRS---RTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAFGPVIVHCSAGVGRTGTFIALGTLLQHI
||.|.| .  .|. .......||....|.|..   |....... .|||||||... . ||..|.|..  ..  |||.|||||||||||||.|| .||...
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMV
.... ||.. . .|.|..|..|.|.. ||.|..||..
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 905-1135 5.3e-63 207.3 In-house 7-239 (239) alignment
Range on Protein: 905-1135
Range on HMM: 7-239/239.0
NRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYR-MRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQpEVYG
|.|||||.||..|||||| || . ..| ||||||.|.  |    .||||||| .  .  ||||| |..   |||||| |.|  . |||.||| .    | 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.skyc

EINVDMLSETEKSDWIVRKFKITK--EKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDW
.. | .      .|.|.| | ...  .   | . .|.|  |||.|||. |   | . |.. . .     | ..||||||||||.|. . ..|.. | .  
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqkt

VDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDA
||.|     .|. | ||.||  |||||| |...|
vdifnyvkairedrphmvqtseqyvfihlavlea

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 905-1133 1.1e-62 206.3 In-house 8-238 (239) alignment
Range on Protein: 905-1133
Range on HMM: 8-238/239.0
NRAKNRYTNILAYDHSRVKLESIDDEPGSDYINANYIPGYR-MRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQpEVYG
|.|||||.||..|||||| || . ..| ||||||.|.  |    .||||||| .  .  ||||| |..   |||||| |.|  . |||.||| .    | 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.skyc

EINVDMLSETEKSDWIVRKFKITK--EKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDW
.. | .      .|.|.| | ...  .   | . .|.|  |||.|||. |   | . |.. . .     | ..||||||||||.|. . ..|.. | .  
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqkt

VDLFGLASEMRQHRNHMIQTEPQYVFIHKAMV
||.|     .|. | ||.||  |||||| |..
vdifnyvkairedrphmvqtseqyvfihlavl

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 905-1137 1.9e-59 195.8 In-house 38-278 (287) alignment
Range on Protein: 905-1137
Range on HMM: 38-278/287.0
NRAKNRYTNILAYDHSRVKLeSIDDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGA-QPEVYG
.  ||||...| .|..|| | | . | |||||||||...|.   |.||.|||...|  ||||. .|..| .....|. || .| ||..|||   .|   |
avkknryadvlPiddtrvll.saegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvG

EINVDMLSETEKS-DWIVRKFKITK-EKRS-RTITHYQFVSWPDHGVPDEAGPALDFVREV---HEVA--SSAFGPVIVHCSAGVGRTGTFIALGTLLQH
   | .|. . |. .. || ... . | |  | .  ....||||....  |   . || .|    |.|  .|  ||..||...|.||.|...|. .|.. 
GysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsr

IKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACK
 .|   ||       .|..|. ..|.  |. .. .|.|   |
ledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk

0041856 (Phosphotyrosine protein) phosphatases II 905-1136 2.6e-54 178.9 In-house 1-171 (182) alignment
Range on Protein: 905-1136
Range on HMM: 1-171/182.0
NRAKNRYTNILAYDHSRvklesiddepGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTqlvergrtkCHRYWPgaqpevyge
|. ||||..|| |||||          ..||||||.. |..  . .|||||||.||. ||.|| .|.. ..||.||         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

invdmlseteksdwivrkfkitkEKRSRTITHYQFVSWPDHGVPDeAGPALDFVREVHEvassAFGPVIVHCSAGVGRTGTFIALGTLLQHikdhDwVDL
                       |.  |....|....||||||||    .|||..||.|      |||.||||||||||||..|.  ....    . |.|
.......................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsl

FGLASEMRQHRNHMIQTEPQYVFIHKAMVDAC
.   ...|..|..|..|. ||.|.. |. . .
eeavklvrsrRpgmvitpnqyfflqlallell

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 905-1051 1.3e-40 134.1 In-house 33-183 (297) alignment
Range on Protein: 905-1051
Range on HMM: 33-183/297.0
NRAKNRYTNILAYDHSRVKLESIddEPGSDYINANYI--PGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPEV-
   ||||..|||.| .||||      ...|||||.|.  |       || .|||| .| ||||.. .||.  ||||...| | || ||  ||| .. |  
slrknryrdilatddtrvkllrv..iterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerl

-YGEINVDMLSETEK--SDWIVRKFKITKEKRSRTITHYQFVSWPDHGVPDEA
  |.. |. ||.|       |. ....   ..|| ..| ||.|||||||| . 
kagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdl

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 905-1134 1.9e-40 133.4 In-house 55-287 (305) alignment
Range on Protein: 905-1134
Range on HMM: 55-287/305.0
NRAKNRYTNILAYDHSRVKLesiDDEPGSDYINANYIPGYRM-RRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPE---
. .||||... . |.| |||   |. . |||| |||.    .  . .|..||||  | |.|| |  ...   |||| . || |. || .||| || |   
aitknryqdvpcqdqsavkl...dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

VYGEINVDMLSETEKSD----WIVRKFKITK-EKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHevaSSAfGPVIVHCSAGVGRTGTFIALGTLLQH
. . | |. .| .   .      .  ...|   ... .. | |.  ||| |||     .|...  .     |   |..||||||.||||| .|.  .|..
lksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair...gsk.vpivvhcsagigrtgtivaieyilek

IKDHD-WVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVD
| .      .  |   .|..| . ||.. ||.|||. |..
iaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 905-1133 4.8e-31 102.8 In-house 35-267 (285) alignment
Range on Protein: 905-1133
Range on HMM: 35-267/285.0
NRAKNRYTNILAYDHSRVKLESIDdepgSDYINANYI--PGyRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPEV-
|   |||... . . .|| |.  |     ||| |...  || . . .||.|||||| |. |||.| ....   ..||  |.| |  ||  |.|    || 
npdlnryadvrcieetrvvlknhd....rdyihaswmrmpg.kdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevv

-YGEINV--DMLSETEKSDWIVRKFKITKEK--RSR--TITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAfGPVIVHCSAGVGRTGTFIALGTLLQ
 .|. ..      |   .  |.  . ... .   |    . | |   |||.  |..| | ... . |..|      |. |||||||||| ||. .     
kfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpke.kpicvhcsagvgrtatfvgidyati

HIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMV
.| .   .... .  |||  | . .|.  |..|..  ..
rimenpniemldivremramrfqavqshmqflflyvvlm

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 905-1009 4.3e-28 93.0 In-house 47-162 (350) alignment
Range on Protein: 905-1009
Range on HMM: 47-162/350.0
NRAKNRYTNILAYDHSRVKLE-S------I-DDEPGSDYINANYIP----GYRMRRA--YIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKC
  |||||.||| |.||||||. |      .     ..|||||||.     . ..     |||||.|||||.|||...  . . .||..||..|| .. ||
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

HRYWPGAQpevYGEINVDM
.|||.  .   | .|.| .
yrYWqegs...ydditvkl

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 905-996 6.6e-19 62.4 In-house 48-155 (349) alignment
Range on Protein: 905-996
Range on HMM: 48-155/349.0
NRAKNRYTNILAYDHSRVKLESIDDEP--------------GSDYINANYI--PGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRT
  ||||| .|| |.||||||.     .                |||||||.  . . . . ||||| ||||| |||...   .. .... |..  | .  
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsle

KCHRYWPG
||..||  
kcdiywqe

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 906-972 1.2e-07 25.6 In-house 38-109 (347) alignment
Range on Protein: 906-972
Range on HMM: 38-109/347.0
RAKNRYTNILAYDHSRVKLESI-----DDEPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQN
 .|||  .    | .|| |          ..   |||| .|     .. || || |||.|  |||.|    .
lsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtk

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 915-1047 3e-11 37.8 In-house 3-126 (130) alignment
Range on Protein: 915-1047
Range on HMM: 3-126/130.0
LAYDHSRVKlesiddepGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERgrtkcHRYWPGAQPEV-YGEINVDMLSET
| .. ||..        | .||||...      . |. || ||  |  |||.|  |.   |.|.|  . |        ||| ..|   | |  .  |.. 
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdr

EKSDWIVR-KFKITKEKRS--RTITHYQFVSWPDHGV
.... |   ...| ..     ...| .|   ||  | 
defknikasnleiesdlneshqaltmfqisnwpsdgt

0044763 (Phosphotyrosine protein) phosphatases II 917-1130 3e-38 126.6 In-house 2-165 (178) alignment
Range on Protein: 917-1130
Range on HMM: 2-165/178.0
YDHSRVKLESIDDEPGSDYINANYIPGYrmrrAYIATQGPlpstfDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPevygeinvdmlseteks
.|..||.|... ....||||||..| ..     |.....|      |.... .|.. ..||.||. .|.|. ||..|||                     
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

dwivrkfkitkekrsrtiTHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAFGPVIVHCSAGVGRTGTFIALGTLLQHikdhDWvDLFGLASEMRQHRN
                   .|... .|||||||     |.||. ..|. ..  |||.|||||||||.||..|.  ....    .. .|.   ...|..|.
..................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp

hMIQTEPQYVFIHK
 ..... |. ....
.ivpnpgqlrqLye

0046846 (Phosphotyrosine protein) phosphatases II 928-1132 5.1e-46 151.9 In-house 7-169 (176) alignment
Range on Protein: 928-1132
Range on HMM: 7-169/176.0
DDEPGSDYINANYIPGYRmrraYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPEVYgeinvdmlseteksdwivrkfkitk
 .....||||||.| |.|    .||||||||.|. ||..| .|.. ...|.||..|| || ||..|||  . . .                         
gldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.........................

ekrsrtitHYQFVSWPDHGVPDEaGPALDFVREVHEVASSAfGPVIVHCSAGVGRTGTFIALGtllqHIKDHDWVDLFGLASEMRQHRN-HMIQTEPQYV
        .|... ||||||||     |.......|. ..  |||.||||||.|||||..|.      .. .  ....   ...|..|  ...||. || 
........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyr

FIHKAM
|.....
flyefe

0043147 (Phosphotyrosine protein) phosphatases II 930-1129 1.1e-46 154.0 In-house 2-154 (172) alignment
Range on Protein: 930-1129
Range on HMM: 2-154/172.0
EPGSDYINANYIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLvergrtkchrywpgaqpevygeinvdmlseteksdwivrkfKITKEK
..|||||||.|...|.  . .|||||||..|..||||| .|.. ..||.||.|                                           ..|.
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.........................................lydpel

RSRTITHYQFVSWPDHGVPdEAGPALDFVREVHE-VASSAFGPVIVHCSAGVGRTGTFIALGTLLqhikdHDWvDLFGLASEMRQHRNHMIQTEPQYVFI
 .|.. .|....|||||||  .   |.|.. ..| .| |  |||.||||||||||||..|.  .|     ... .|.   ...|..|....|.. || |.
lerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl.sleeavalvrekRpgavqnpsqyrfl

H
.
y

0051429 (Phosphotyrosine protein) phosphatases II 931-1138 1.9e-57 190.2 In-house 2-227 (272) alignment
Range on Protein: 931-1138
Range on HMM: 2-227/272.0
PGSDYINANYIPGYRM---RRAYIATQGPLPSTFDDFWRMtWEQNSHVIVMLTQLVERGRTKCHRYWP------------GAQPEVYGEINVDMLSETEK
| |.||||....||     ........|||| | .||||. .|.. ..||.|....|||| ||.||||            .|..  || . | .|||. .
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

SDWIVRKFKIT---KEKRSRTITHYQFVSWPDHGVPDEAgpALDFVREVHEvassaFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVD--------L
.|.|.|.. .|   . . .|...|... .|||||||.||   |........      |||.||||||..||||..||  ||. . ... ||        |
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

FGLASEMRQHRNHMIQTEPQYVFIHKAMVDACKS
..  .|.|..| ...||| ||.|...|.... .|
eeaveelraqrpgavqteeqylflyeallellrs

0036282 (Phosphotyrosine protein) phosphatases II 932-1130 3.8e-51 168.5 In-house 1-164 (174) alignment
Range on Protein: 932-1130
Range on HMM: 1-164/174.0
GSDYINANYIPGYRMRRAYIATQGPLPstfddFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGaqpevygeinvdmlseteksdwivrkfkiTKEKRS
|||||||... ...  . .||.||||.     ||.| .|......|||....|.|..||..|||                              ..|  .
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.............................lredle

RTITHYQFVSWPDHGVPDEAGpALDFVREVHEVASS-AFGPVIVHCSAGVGRTGTFIALGTLLQHIKdHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHK
|.. .|... |||||||| .   |.||..|.|. |.   |||.||||||||||||..|.  .|.... .. || . |  |.|..| .|.||. || |...
rlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy





0051082 (Phosphotyrosine protein) phosphatases II 932-1131 5.7e-38 125.2 In-house 2-148 (151) alignment
Range on Protein: 932-1131
Range on HMM: 2-148/151.0
GSDYINANYIPGYrmrraYIATQGPLPstfdDFWRMTWEQNSHVIVMLTQLVERGrtKCHRYWPGAQpevygeinvdmlseteksdwivrkfkitkekrs
 |||||..|. |.     .....|||.    ||... .|..  .||.|....|||  .|..|.| ..                                 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

RTITHYQFVSWPDHGVPDEAGPALDFVREVHEvasSAFGPVIVHCSAGVGRTGTFIALGTLLQHikdhdwVDLFGLASEMRQHRNHMIQTEPQYVFIHKA
....|.....|||.|.|.    .|.|.... .      |||.||||||.|||||..||  .|..      |.|.   .|.|..| ...|.. |..|...|
ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfa





0049260 (Phosphotyrosine protein) phosphatases II 940-1130 7.4e-44 144.4 In-house 1-144 (152) alignment
Range on Protein: 940-1130
Range on HMM: 1-144/152.0
YIPGYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWpgaqpevygeinvdmlseteksdwivrkfkitkekrsrtitHYQF
.|.||.| ...||||||.| |..||||| .|.. ..|||||.|.|.|. ||..|.                                         .|..
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.........................................qylh

VSWPDHGVPDEAGPALDFVREVHEVASSAFGPVIVHCSAGVGRTGTFIALGTLLqhikdhDWVDLFGLASEMRQHRNHMIQTEPQYVFIHK
. |||||||| .   |.... ... | .  |||.||||||||||||..|.  .|        |.|.   . .|..|....... |. |...
lpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 943-996 3.5e-09 30.5 In-house 231-281 (440) alignment
Range on Protein: 943-996
Range on HMM: 231-281/440.0
GYRMRRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERgrtKCHRYWPG
||  . |.|||| || ||  ||||.  . .   |.|| || ..    |  ||| 
gyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpv

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 947-1130 2.7e-27 90.3 In-house 4-198 (199) alignment
Range on Protein: 947-1130
Range on HMM: 4-198/199.0
RRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQP--EVYGEINVDMLSETEKSDWIVRKFKITK----EKRSRTITHYQFV
.| ||||| ||  |. |||.| ||  |  |||. .      .    ||| ..     || ..|   . | |.|. .  . .|.       .| |.|||| 
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWPDHGVPDEAGpALDFVREVHEVAS----SAFGPVIVHCSAGVGRTGTFIALGTLLQHI--KDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHK
|| ..  |. |   . ||    ||.         ||||||| | | || |.||   ..         |||| .|  .|| |  .| . ..| ||..
swkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 947-1130 3.3e-27 89.9 In-house 3-197 (198) alignment
Range on Protein: 947-1130
Range on HMM: 3-197/198.0
RRAYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQP--EVYGEINVDMLSETEKSDWIVRKFKITK----EKRSRTITHYQFV
.| ||||| ||  |. |||.| ||  |  |||. .      .    ||| ..     || ..|   . | |.|. .  . .|.       .| |.|||| 
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWPDHGVPDEAGpALDFVREVHEVAS----SAFGPVIVHCSAGVGRTGTFIALGTLLQHI--KDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHK
|| ..  |. |   . ||    ||.         ||||||| | | || |.||   ..         |||| .|  .|| |  .| . ..| ||..
swkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 949-1047 5.2e-07 23.5 In-house 138-235 (244) alignment
Range on Protein: 949-1047
Range on HMM: 138-235/244.0
AYIATQGPLPSTFDDFWRMTWEQNSHVIVMLTQLVERgrtkcHRYWPGAQP-EVYGE-INVDMLSETEKSDWIVRKFKITKE--KRSRTITHYQFVSWPD
 || || ||  |  |||.|  |.   |.|.|  . |        ||| ..| | | | | | .    |  .    ...|  .  .  ...| .|   || 
eyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwps

HGV
 | 
dgt

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 956-1142 6.3e-22 72.4 In-house 99-291 (302) alignment
Range on Protein: 956-1142
Range on HMM: 99-291/302.0
PLPSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPEV--YG-------EINVDMLSETEKSDWIVRKFKITKEK----RSRTITHYQFVSW
|  || . .| .  . |  ..| |...|| .  ||  |.     ..  .|       ... |.   |.| .  . . .|. ||      .|.   .| .|
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDHGVPDEAGPALDFVREVHEVASSafgpVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIhkaMVDACKSSMSK
|||| |.|| .||| ..       .    |.||||||||||||..|.   .|  . ..  ||  .   .|| |   .|.| | ...   ..   |. | |
pdhGapkeaytaldilkfcesykkn....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl...llcvtkglmek





subfamily_hpo-7_pd Subfamily hpo-7 958-1127 1.1e-18 62.1 In-house 44-218 (263) alignment
Range on Protein: 958-1127
Range on HMM: 44-218/263.0
PSTFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPEVYGEINVDMLSETEKSDWIVRKFKITK----EKRSRTITHYQFVSWPDHGVPDEAGP
  | | |...   ....|.|||.   | |. || .|.|  . |     ||.. .   .|| ...  ....     |. .|..||... |...  | .|  
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelare

ALDFVRevheVASSAfGPVIVHCSAGVGRTGTFIALGTLLQ----HIKDHDWV--DLFGLASEMRQHRNHMIQTEPQYVF
 |  ..    ||     ...||||.|.||.  |    .. |     ..  . |  |   |  |.|..|.  |.|  |  |
ilnilk....varns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLaf

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 960-1127 1.1e-21 72.1 In-house 40-212 (255) alignment
Range on Protein: 960-1127
Range on HMM: 40-212/255.0
TFDDFWRMTWEQNSHVIVMLTQLVERGRTKCHRYWPGAQPEVYGEINVDMLSETEKSDWIVRKFKIT----KEKRSRTITHYQFVSWPDHGVPDEAGPAL
| | |...   ....|.|||. . | |. ||..|.|  . |     .|.. .    .| ..|  .||    . |. .|..||..  |...  |..|   |
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

DFVRevheVASSAfGPVIVHCSAGVGRTGTFIALGTLLQ----HIKDHDWV--DLFGLASEMRQHRNHMIQTEPQYVF
  ..    |.  .  .|.||||.|.||. .|.    . |     ..  . |  |   |  |.|..|.  |.|  |  |
nilk....vvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlaf

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1015-1135 8.1e-26 85.3 In-house 74-193 (440) alignment
Range on Protein: 1015-1135
Range on HMM: 74-193/440.0
KSDWIVRKFKitKEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASS-AFGPVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQ
.||.|   .   .   |||. .|.. .|||.|||  ||| | ....| |     . ||..||||||.||||  ||. ..|.. |  | .|.| . . ||.
dsdyinasyi..ngiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrn

HRNHMIQTEPQYVFIHKAMVDA
 | .|.||  ||.|.|.|....
nrpqmvqtpeqyafvheavleg

0048076 (Phosphotyrosine protein) phosphatases II 1024-1131 2.8e-25 84.1 In-house 37-138 (145) alignment
Range on Protein: 1024-1131
Range on HMM: 37-138/145.0
KITKEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAfGPVIVHCSAGVGRTGTFIALGTLLQhikdHDwVDLFGLASEMRQHRNHMIQTEP
  ..|  .|....|....|||||||| .   |.|.. ..|. ..  |||.||||||||||||..|.  .|.    .. |.|.    ..|..| ...... 
tselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpnpg

QYVFIHKA
|. |....
qlrflyef

0048179 (Phosphotyrosine protein) phosphatases II 1025-1130 6.6e-24 79.7 In-house 40-139 (144) alignment
Range on Protein: 1025-1130
Range on HMM: 40-139/144.0
ITKEKRSRTITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAfGPVIVHCSAGVGRTGTFIALGTLLqhikDHDwVDLFGLASEMRQHRNHMIQTEPQ
  .|   |....|....|||||||| .   |.|.. ..|. ..  |||.||||||||||||..|.  ..     .. ..|.    ..|..| ...... |
yepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgq

YVFIHK
. |...
lrfLle

PTEN_1 1028-1088 6.9e-08 27.5 In-house 89-149 (196) alignment
Range on Protein: 1028-1088
Range on HMM: 89-149/196.0
EKRSRTITHYQFvSWPDHGVPDEAgPALDFVREVHEVASSAF--GPVIVHCSAGVGRTGTFIA
| . . .....| ...|||.|. .   .|......| ..|.   . |.||| ||.||.|| .|
effksgveylhf.pieDhgapsls.elfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva

subfamily_PTPDC1_pd Subfamily PTPDC1 1031-1129 3.9e-08 27.9 In-house 80-169 (182) alignment
Range on Protein: 1031-1129
Range on HMM: 80-169/182.0
SRTITHYQFvSWPDHGVPDeAGPALDFVREVHEVASSAfgPVIVHCSAGVGRTGTFIALGTLlqHIKDHDWVDlfgLASEMRQHRNHMIQTEPQYVFIH
 . |..|.| .|.|.||.     .|| |. |. . .     | ||| || ||||  ||   .  . |. .  .     . .|..| . |||  |  ...
eqgiyvynf.gwkDygvas.leriLdivkvvafalqeg..kvavhChaGlGrtGvliacylv..yakrltaek...aiklvrskrpksiqtreqvelvk

PTPc_DSPc_SM00012 1033-1133 5.6e-34 111.9 In-house 1-104 (105) alignment
Range on Protein: 1033-1133
Range on HMM: 1-104/105.0
TITHYQFVSWPDHGVPDEAGPALDFVREVHEVASSAF--GPVIVHCSAGVGRTGTFIALGTLLQHIKDH-DWVDLFGLASEMRQHRNHMIQTEPQYVFIH
|..||.. .|||||||.|. . |...|.|... . .   .||.|||||||||||||.|| .|||..... . ||.| . .|.|..|..|.||| ||.|..
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

KAMV
.|. 
rall

0038934 (Phosphotyrosine protein) phosphatases II 1036-1129 2.3e-09 32.7 In-house 81-170 (194) alignment
Range on Protein: 1036-1129
Range on HMM: 81-170/194.0
HYQFVSWPDHGVPDEAGPALDFVREVHEVASS-AFGPVIVHCSAGVGRTGTFIALgtLLQHIKDHdwvDLFGLASEMRQHRNHMIQTEPQYVFIH
.|    .||.|..      |.|.. |.|. .  . | | ||| ||.|||||..|    | .  .    ..      .|. |...|..  ..  ..
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa..YLiyrlgm...saeeAialfrekRpgaipnqdyleall

subfamily_CDC14_pd Subfamily CDC14 1049-1089 6.4e-07 23.5 In-house 243-283 (328) alignment
Range on Protein: 1049-1089
Range on HMM: 243-283/328.0
DEAGPALDFVREVHEVASSAFGPVIVHCSAGVGRTGTFIAL
| . |    |..  |.| .| | ..||| ||.|||||.|| 
DGstPsdaivkkfleiaekaeGaiavhCkaGLGrtGtLiac

subfamily_CG42327_pd Subfamily CG42327 1066-1133 1.5e-14 48.4 In-house 244-312 (319) alignment
Range on Protein: 1066-1133
Range on HMM: 244-312/319.0
SSAFGPVIVHCSAGVGRTGTFIALGTLLQHIKDH-DWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMV
 . .||..|||| ||||||. ||    ......    ||.  | | .|. | . ..|  || ||.| . 
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvls

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1066-1132 3.5e-11 37.4 In-house 259-340 (350) alignment
Range on Protein: 1066-1132
Range on HMM: 259-340/350.0
SSAFGPVIVHCSAGVGRTGTFIALGTLLQ------HIKD-----HDWVDLFG----LASEMRQHRNHMIQTEPQYVFIHKAM
..   |..||||||||||||...|  ||.      ....     . .  ..     .  |.|. |  |.|.  |..||..|.
narsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeal

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1068-1099 1.4e-06 21.9 In-house 264-297 (349) alignment
Range on Protein: 1068-1099
Range on HMM: 264-297/349.0
AFGPVIVHCSAGVGRTGTFIALGTLLQ--HIKDH
   ...|||||| ||||... |  ||.  .   .
qlstllvhcsaGcGrtGvlvtldlllsileplqn

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1071-1134 3.3e-09 31.0 In-house 230-293 (297) alignment
Range on Protein: 1071-1134
Range on HMM: 230-293/297.0
PVIVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVD
...|||||||||.|  .   ..|. .. .   |   . | .|. |  ..||  |. ....|.. 
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1073-1137 2.9e-17 56.8 In-house 2-66 (69) alignment
Range on Protein: 1073-1137
Range on HMM: 2-66/69.0
IVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACK
.||||.| ||||||||.   .  ||    ||.|     ||. |  |.  | .|.||| |.|.| |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealk

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1073-1137 1.5e-16 54.5 In-house 1-65 (69) alignment
Range on Protein: 1073-1137
Range on HMM: 1-65/69.0
IVHCSAGVGRTGTFIALGTLLQHIKDHDWVDLFGLASEMRQHRNHMIQTEPQYVFIHKAMVDACK
.||||.| ||||||||.   .  ||    ||.|     ||. |  |.  | .|.||| |.|.| |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealk