Gene dep-1 in Caenorhabditis elegans

Synonym: CELE_F44G4.8, dep-1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRB
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP049_AA protein Get Run
CeleP049_AA_1054-1336 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
fn3 Fibronectin type III domain 642-730 2.7e-13 43.0 Pfam-A 2-85 (85) alignment
Range on Protein: 642-730
Range on HMM: 2-85/85.0
AVQDLKVEPLNSYSVMLTWLPPALPNGILTHYAVNVTKIGSDEtrtidVGVSSNRSDHTVQVVIDELFGGHTYSFSVRAVTEAGFGENS
|...|.|.. .| |..|.| ||. ..| .|.| | . . |. |     . .. ... .| .|.. .|  | .|.|.|.||..|| |. |
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge.....ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS

0050432 (Phosphotyrosine protein) phosphatases II 1038-1335 4.3e-93 307.3 In-house 12-299 (308) alignment
Range on Protein: 1038-1335
Range on HMM: 12-299/308.0
YTVVTGANTNKSRPVRIEDFADHVrlMSADSDFRFSEEYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLsnpnNiEGGDYINANYVPGF--
....    ...| .....|.. ..  ..|..  ...||.  ...| .  .  ...|| |..|||...|. ||||||||    . || |||||.||.|.  
llfrdtsilvsslklsvldllkll..ekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyss

SSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHEN-VPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDgrVTRFVRHW
 ..|.|||.|||||.| ..||.| |||... |. |||.||.|| ||.||||. ..  .. ||.. ||.. |...|....| ..|...| .   .|.|.|.
klprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg..esrtvthf

HYMAWPDFGAPSHPNGIIQFSRMFRHHLphspHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQV
||..|||.|.|..|. ...| .. |..|     . |..|||||||||.|||| .| ||.    .  .|||..|. .|  |..|||...||.|.....|  
hytnWpdhgvPpspeilldflelvrksl....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralley

L
|
l

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1042-1219 2.3e-13 44.3 In-house 36-212 (244) alignment
Range on Protein: 1042-1219
Range on HMM: 36-212/244.0
TGANTNKSRPVRIEDFADHVRLMSA----DSDFRFSEEYDMMRNVGV-GQSVAA-SELPINRPKNRFTNIPSYDHSRVKLSNPNniEGGDYINANYVPGF
  ||. |.| . |  | .   ..|.     ||.  ..  .  .|.     ||   .  | |  |||      .| .|| ||. .   |  |||| .|  .
lsanatknryinilpfdetrvilssskkegsdyinanyiqgsqniirpdpsvmkdafnpnnswknregaglpfdfnrvplskgs..mgntyinasfvgcl

SSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKcVEKGrdkcHQYWPDHENVPVLYGDIEVTIVAEKEFDEFVIRDIRLE
    |.| .| ||  |   ||.|  |.    .. |   ||.      .|||| | .     || ||.    || .    .. .|
grtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgs.veee....deywpdseplewyeeditvtltdrdefknikasnleie

0045450 (Phosphotyrosine protein) phosphatases II 1045-1335 7e-88 290.6 In-house 2-304 (307) alignment
Range on Protein: 1045-1335
Range on HMM: 2-304/307.0
NTNKSRPVRIEDFADHVRLMSADSDFRFSEEYDMMRNVGV--GQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNI-EGGDYINANYV--------P
... |........  .|.|. .|.  .. .|. ....| |    .  ...|| |..|||...|. |||.|||||....  |..|||||.||        .
dlplslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllld

GFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHeNVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSgPDGRVTRFVRH
|. . |.|||.||||| | ..||.| |||.. .|. ||..||.|| ||.|||||  . .. ||.. || . |.. |....| .... .      .|.|.|
gydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdl.dgtgesrtvth

WHYMAWPDFGAPSHPNGIIQFSRMFRHHLPHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDP---IDVFGTVCEMRYERCQMVQNEQQYIFIHYC
.|| .|||.|.|.... ...| .. |..| ..| . |..|||||||||.|||| .. .|.    .     .|.. .|...|  |...|||..||.|....
fhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyea

ILQVL
.|. |
llell

subfamily_PTPRA_pd Subfamily PTPRA 1046-1334 1.4e-76 252.5 In-house 7-294 (330) alignment
Range on Protein: 1046-1334
Range on HMM: 7-294/330.0
TN-KSRPVRIEDFADHVRLMSADSDFRFSEEYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAA
.| |  |. .|.. . .|  |||   .| ||.. .    .  .. ...   |. |||. ||  ||.||| ||. . .|  ||||| .. |.  . .||||
gnkkyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaa

QGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENvpVLYGDIEVTIVAEKEFDEFVIRDIRLEkSGPDG---RVTRFVRHWHYMAWPD
|||.  | . ||.| |||.  .|. ||.  |. ..||.|||||.    | ||.| |..  |..  .. .|.. ..   ||.   . .| || .|. .|||
qGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGl..vtyGnirvevedetvlvdytvrkflvq.qlpdatrekksrlvrqfhftswPd

FGAPSHPNGIIQFSRMFRHHLPHSPHnaPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQV
.| |..| |.... .  ..  . |    | .|||||||||.|||| .| .|.       .|||..| ..|  |.|||| ..|| ||.  .|. 
vGvPfepiGmlkllkkvkklnqqsag..pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley

subfamily_PTPRB_pd Subfamily PTPRB 1047-1338 4.3e-129 424.7 In-house 2-288 (293) alignment
Range on Protein: 1047-1338
Range on HMM: 2-288/293.0
NKSRPVRIEDFADHVRLMSADSDFRFSEEYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQG
.||.|...|.|..||. |.||||.||||||.....||  |.|.|.||..|| |||.||| .||||||||.. .. .| |||||||.||..|.|||||.||
kkskpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqG

PLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENvPVLYGDIEVTIVAEKEFDEFVIRDIRLEKsgpdGRVTRFVRHWHYMAWPDFGAPS
|||.|.|.||.|.||... .|. ||..||||. ||..|||..|. |||||||.||.|||.| ...|||....||    .. .| ||..|...|||.| |.
PlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadee.pvlyGdikvtlvaeeeledwvirelkiek....ekeerkvrqyhftsWpdhgvPe

HPNGIIQFSRMFRHHLPHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQGS
... ...| |..|... .. ...|..|||||||||.||||..|||||. .  | .|.||.|.|.| ||...||.|.|||||| |.|..|. .
ktktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkk

0039614 (Phosphotyrosine protein) phosphatases II 1048-1336 4.7e-88 290.8 In-house 10-290 (297) alignment
Range on Protein: 1048-1336
Range on HMM: 10-290/297.0
KSRPVRIEDFADHVRLMSADSDFRFSEEYDMMRNVGVGqsVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNI-EGGDYINANYVPGFSS-RREFIAAQ
.| |.... .. ...|. |.|  .. .|. .. .. .      ..|| |..|||...|. ||||||||. ...  .. |||||.||.|..   |.|||.|
esipiplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatq

GPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRdKCHQYWPDHENvpvLYGDIEVTIVAEKEFDEFVIRDIRLEKsgpdGRVTRFVRHWHYMAWPDFGAP
|||| | ..||.| |||....|. |||.||.|| ||.||||. ..    |||. || . ... | ...| .....    .  .|.|.|..|. |||.|.|
gPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn....ngesrtvthfqytgwpdhgvp

SHPNGIIQFSRMFRHHLPHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQ
.... ...| .. |..| ..| . |..|||||||||.|||| ....|.    .  .||. .|.|.|  |...||...||.|.....|. |.
pslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1048-1336 1.7e-57 189.8 In-house 6-285 (297) alignment
Range on Protein: 1048-1336
Range on HMM: 6-285/297.0
KSRPVRIEDFADHVRlMSADSDFRFSEEYDMMRNVGVGQSVAasELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSrrEFIAAQGP
. ||. . |||  |.  . ..|.   |  .. .     | ||  |  .| .|.|..||  || |||||   |.    ||.|| .|.|.    ..|. | |
errpiplsdfatlvq.knrhtdvfseeflclpeaniqpqtva..ekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmP

LPTTRDHFWQMTWEQQCPAIIALTKCVEKGRdKCHQYWPDHENVPvlYGDIEVTIVAEKEFDEFVIRDIRLEKSGPdgRVTRFVRHWHYMAWPDFGAPS-
 ..| . ||.| ...|  .|. |..  |. . || .||.|.  ..  .||. |.. . .|   |. |.. ..|. .  ...|.|. .... |||   .  
mkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt..fGdvsvvllsvsereGfikrelevtkgka..karrvvkqyqfveWPdkaverk

-HPNGIIQFSRMFRHHlpHSPHNA-PTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQ
 . . ....    |..  .| ..  | .|||.||||| | ...||  .      . .|.||.|  .| || ..|| ..|| |..  .|..| 
dsassllklisevrkd..fsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleall

subfamily_PTPRD_pd Subfamily PTPRD 1049-1336 7.6e-107 353.3 In-house 2-282 (564) alignment
Range on Protein: 1049-1336
Range on HMM: 2-282/564.0
SRPVRIEDFADHVRLMSADSDFRFSEEYDMMRNVgVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPL
|.|. ......||. . |.||..|.|||  ...     .. |.. |.|..|||. ||  ||||||.||. .. || |||||... |. .|...||.||||
skpipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPl

PTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHeNvPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDGRvtRFVRHWHYMAWPDFGAPSHP
..| . ||.| |||..  |. |||..|||..|||.|||.. . .  ||...||...|.|. ...||...|.|.  .    | ||..|...||| |.| ..
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkksses..reVrqFhFtsWPdhgvpesa

NGIIQFSRMFRHHLPhsPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQ
...... |  |.. .  |.. |..|||||||||.|||| || .|.     . .|....| ..| .|  |||.|.||||||. ||. |.
tslLdlirkvralne..pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaileala

0051299 (Phosphotyrosine protein) phosphatases II 1049-1334 3.1e-96 317.5 In-house 2-285 (288) alignment
Range on Protein: 1049-1334
Range on HMM: 2-285/288.0
SRPVRIEDFADHVRLMSADSDFRFSEEYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPL
......|.....|. . |..  .. ||....... .  .. |. || |..|||...|. |||||||||.....||.|||||.|..|. . |.|||.||||
dteisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPl

PTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDheNVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSG--PDGRVTRFVRHWHYMAWPDFGAPS
|.| ..||.| |||... |. |||.||.|| ||.||||.  . .. |||| ||.. |...|....| ..... .    .  .|.|.|.||..|||.|.|.
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpd

HPNGIIQFSRMFRHHLPhsPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQV
.|. ...| |..|..|.  ... |..|||||||||.|||| .| ||.   ..  .||...|. .|  |..|||...||.|.....|  
spellldflrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1049-1138 1.3e-11 38.6 In-house 3-89 (440) alignment
Range on Protein: 1049-1138
Range on HMM: 3-89/440.0
SRPVRIEDFADHVRLMSadSDFRFSEEYDMMrNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSR
 ||. . ||||.|.         | .|. ..   |. |    . || |. |||. || .|||||| | . . .   ||||| |. |  ||
qrpiivadfadyvqnnr..rsrafedewsll.psglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingiesr

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1050-1336 8.6e-80 263.2 In-house 3-284 (319) alignment
Range on Protein: 1050-1336
Range on HMM: 3-284/319.0
RPVRIEDFADHVRLMSADSDFRFSEEYDMMRNvGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLP
............. . . ..  . .|. .... .| ...  .. ..|..|||..|| .||..||.||. ...|| |||||... |.  |..|||.|.|| 
teievqeLkerlkalastgetllekefkllke.avndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPle

TTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHEnvPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDgrV-TRFVRHWHYMAWPDFGAPSHP
.| . ||.| ||...  .. ||| |||.. |...|||...  .. || . ||.  |.| ....||.. |.|   .  | || | |..|..||| . | . 
ntiedfWrmvWeeessivvmltklveklkvklkkywpeen..feeyGrlivtleeeeeledyiirklklnkksse..vetRevkhfqyteWpdhdvPeka

NGIIQFSRMFRHHLpHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQ
 ..... .  |.   . ... | .||||||||| |||| .|  |.  .    .||| || ..|  |  |||...||.||.. .|....
tslldllkrirksr.ektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1050-1334 1.4e-62 206.4 In-house 4-278 (315) alignment
Range on Protein: 1050-1334
Range on HMM: 4-278/315.0
RPVRIEDFADHVRLMSADSDFRFSEEYDMMRNvGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLP
.|. ....  .|    | .   | ..|. .   |  . .  .    |. |||. || .||.|||.|   .| .. ||.|||...|.. .| .||||||..
qpipldqlityvaqkkastkngfkqdyesipg.gqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnv

TTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHenvPVLYGDIEVTIVAEKEFDEFVIRDIrlekSGPDGRVTRFVRHWHYMAWPDFGAPSHPN
.. . ||.. .|...  |. ||. ||. . |. .||||.    |.|| | || . |. ..|. .| .    |   |   | |  .|| .||| | | .  
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtl....svvfgdnirevvqlhytswpdmgvpkyti

GIIQFSRMFRHHLPHSPhnAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQV
 .... |  . |   |   .. .|||||||||.||||..| .|.     . |||.  .  .|  | .|||  .|| ||.  .|. 
plmnlirtvkqhhtnsv..gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1050-1146 5.6e-14 46.1 In-house 3-95 (95) alignment
Range on Protein: 1050-1146
Range on HMM: 3-95/95.0
RPVRIEDFADHVRLMSADSDFRFSEEYDMMR-NVGVGQSVAASElpINRPKNRFTNIPSYDHSRVKLSNPNNiegGDYINANYVPGFSSRREFIAAQG
.|. .  |  ||  | ..||  | .|.  .    |   .| .||   | ||||| ||  || .|| |.   .    ||||| .| |.. .  .|||||
kpihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsse..anipknrflnifpydatrvvlttkrd...sdyinacfvdgyarkncyiaaqg

subfamily_Ptp69D_pd Subfamily Ptp69D 1051-1334 1e-74 246.5 In-house 3-285 (307) alignment
Range on Protein: 1051-1334
Range on HMM: 3-285/307.0
PVRIEDFADHVRLMSADSDFRFSEEYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPT
.. |.| .. ..    |.|| . .||... .  . .|  .||   |  |||. .| ..|. ||||.. |  |  |||||... |.  ...|||||.|. .
aiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPvea

TRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHenVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSG---PDGRVTRFVRHWHYMAWPDFGAPSH
| . ||.| .||.   |. |..  || |.||..|||.     | |||| |..| |.. ....||.. . | .   ..   .| |  .||..|.|. .| .
tigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPev

PNGIIQFSRMFRHHLPHSphNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQV
..|.... .. |..  ..  ..| .|||||||||||.|...| |||     | .|.| ||...| .|  .||. .||.|..  .|. 
argllklieqvrelykln..rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldy

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1051-1336 5e-68 224.5 In-house 3-284 (305) alignment
Range on Protein: 1051-1336
Range on HMM: 3-284/305.0
PVRIEDFADHVRLMSADSDFRFSEEYDMMRNVgvGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPT
.. ..|.| ... ....||  . ..|... .   ..|.   .   |. |||...|  .|..|..|.. .. .  |||||.|| |.... ..|.|||||..
iialddlaayikearvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkn

TRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPdGRVTRFVRHWHYMAWPDFGAPSHPNG
| . ||.. .| .   |. ||| || |.|||.||||. .. .. .|...|..  ||.. ....|.... .     . .| | ...   ||| | |  .  
tvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede.dkesrtvlqyqltdWPdhGvpqfats

IIQFSRMFRHHLPHSpHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQ
.... .  ...  .. .. | .|||||||||.|.||..|  |.     . .|||. . ..| .| .|||. .|| |.|  . . ..
llslikrvqkdqkkd.kgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelit

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1052-1338 2.4e-91 301.1 In-house 2-283 (318) alignment
Range on Protein: 1052-1338
Range on HMM: 2-283/318.0
VRIEDFADHVRLMSADSDFRFSEEYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTT
. .||...||| . .. .  .||||...  .    .   |  |.|. |||..|| .|||.||||.. .. || |||||||..|. .....||||.||| |
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

RDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHEnvPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDgrVTRFVRHWHYMAWPDFGAPSHPNGI
 . ||.| |||..  |. ||...|.|..|.|.|||...  .  ||.. |..  |.|....|.| ....... .   .| || .|| .||| | |... ..
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskg..srsygklvvelkeevelsdyvlrefkvtrteee..esrqvrqyhytsWpdegvpesgasl

IQFSRMFRHhLPHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQGS
... |  ..   ... . |..||||||||| |.|| .| ||.       .|||.|| ..| .|  ||| |.||.||.  .|. |.  
ldlvrqvsk.aqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasg

0043336 (Phosphotyrosine protein) phosphatases II 1052-1333 1.7e-86 285.4 In-house 2-275 (278) alignment
Range on Protein: 1052-1333
Range on HMM: 2-275/278.0
VRIEDFADHVRLMSADSDFRFSEEYDMMRNVGVgQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTT
....|...... . ...  ....|.  .... .  .   ..|| |..|||...|. |||||||||. .. .. |||||.||.|..  |.|||.||||| |
isvkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

RDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPdheNVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDGRvtRFVRHWHYMAWPDFGAPSHPNGI
 ..||.| ||.... |. ||..||.|| ||.||||   . .. |||. || . |...| ...|...... | .    |.|.|.||..|||.|.|.... .
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdges..rtvthyhylgwpdhgvpeslsll

IQFSRMFRHHLPhsPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQ
..| ...|..|.  . | |..|||||||||.|||| ...||.    .  .|.. .|.|.|  |...||...||.|.....|.
ldflkavreale..dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle

subfamily_PTPRG_pd Subfamily PTPRG 1052-1337 1.2e-76 253.2 In-house 1-289 (563) alignment
Range on Protein: 1052-1337
Range on HMM: 1-289/563.0
VRIEDFADHVRLMSADSDFRFSEEYDMMRNVGVGQ--SVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGG-DYINANYVPGFSSRREFIAAQGPL
| ...|| ||  . ||.| .||||.. . .  . .   . .|. | |. ||| .|| .||.||||||.  ....  |||||||. |.   ..|||.||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

PTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDheNVPVLYGDIEVTIVAEKEF-----DEFVIRDIRLEKSgPDGRVTRFVRHWHYMAWPDFG
..| | ||.| |||.   |. .|. ||.|| ||..|||   . .. || ..||...|. .      ..||....|.|   .    . ||..||  ||| |
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkk.kqcdteklvrqyhytkWPdhg

APSHPNGIIQFSRmfRHHLPHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQG
.|.|.   ..| .  ..   .  .  |..|||||||||.||.| .| ||.     . ..|||..  .| .|  .||.| ||||.|  .|.....
vPehslpvLifvk..kssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias

subfamily_PTPRK_pd Subfamily PTPRK 1052-1348 1.1e-70 233.0 In-house 4-291 (314) alignment
Range on Protein: 1052-1348
Range on HMM: 4-291/314.0
VRIEDFADHVRLMSADSDFRFSEEYDMMRNVgvgqsVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTT
.|..|  ... |. .   . | |||. . .        |.    || |||...| .||.|||.|   ..    |||||... ..   ..||..||||. |
irvadllqsiallkraegygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqet

RDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENVpvlYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDGRVTRFVRHWHYMAWPDFGAPSHPNGI
   ||.. ....| .|. ||. ||.|| || .|||.. .|   ||||.|..|  .   |.|.|  |.||.      .| ||......|||.. | . .|.
vkdfWrlvydencasivmltelvevgrvkClkyWPedtev...ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgl

IQFSRMFRHHLPHspHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQ-VLQGSSPSPTSTSTG
... |   .. ..  .. ...|||||| ||.|||| || .|.     . .||| .| ..| ..  ||. |.||.||.  ||. .| | .  |.|    
lklvrrvkksqee..eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefka

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1052-1336 1.6e-61 202.7 In-house 2-284 (290) alignment
Range on Protein: 1052-1336
Range on HMM: 2-284/290.0
VRIEDFADHVRLMSADSDFRFSEEYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIE--GGDYINANYVPGFSSRREFIAAQGPLP
.....|...|    |  . .| ... |. .    ..|     . |...|||.||  ||  |. | . .. .    .|||| |. |.. ....||.|||..
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

TTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHeNVPVlYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDgRVTRFVRHWHYMAWPDFGAPSHPN
 |  .||.. |......|. ||. .|.|..||.|||||. ..   || ...... |....|...| ......  .   .. | ...  .|.. |   .|.
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds.dtka.ygefsikllneetlneyierklevknknsa.gakqsvtqyqitnwdstgkvtnpq

G-IIQFSRMFRHHlpHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQ
. ......| . .  . . | . .||||..||||..|....  ..       ||||  . ..|  . ..|| .||| .|.. .|. |.
tillvieemyktq..rkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1053-1336 3e-58 192.1 In-house 3-279 (287) alignment
Range on Protein: 1053-1336
Range on HMM: 3-279/287.0
RIEDFADHVRLMSADSDFRFSEEYDMMRNVGVGQ-SVAASELPINRPKNRFTNIPSYDHSRVKLSnpnnIEGGDYINANYVPGFSSRREFIAAQGPLPTT
 .| |.. |.   | ..  |.. . .. .|.  . .|  .  . |..|||.|.|  .|  || |      |  ||||| .. |......||.|..|.  |
pvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfnt

RDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENvpVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDGRvTRFVRHWHYMAWPDFG-APSHPNG
   ||.. .... .||. |..  |. ...|.||||....  |..|. ..... |.  .....|........ .|  .. |. ... .|.. |  ...   
arnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagd.kqqvkqyqitnWdstgkvtepqti

IIQFSRMFRHHlpHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQ
.... .|.. .  . . |.. .||||..||||..|....  .. .     ||||  . ..|  . ..||  .||.||   .|. |.
llvieemyktq..rkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyld

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1054-1337 2.4e-84 277.8 In-house 6-281 (288) alignment
Range on Protein: 1054-1337
Range on HMM: 6-281/288.0
IEDFaDHVRLMSADSDFRFSEEYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRD
|..  ..|  .||..   |||||. . ...  .|| |..|. | .|||. || .||. |||| . .. .| |||||.|. |  .....||.||||. | .
ispv.akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvn

HFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENvPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDgrvtRFVRHWHYMAWPDFGAPSHPNGIIQ
.||.. .|..   |. ||. ||.|. ||..|||| .. |..||...||.| .|| ..|| | . |||.. .    . . ...|.|||| | |   . ...
dfWelvyenktstivmltelveggktkCeeYWPdadk.pknyGsvtvtlveskeledfvlrklllekkkte....leitqyqylaWpdhgvPeskaplle

FSRMFRHHLPHSphNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQG
. |.     .      | ||||||||||.||||..| |..     | |||.|||...| .| ..||...||.||. ..|.. . 
llrqvkvanqad..tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsliee

subfamily_PTPN9_pd Subfamily PTPN9 1054-1333 6.2e-71 233.8 In-house 3-288 (297) alignment
Range on Protein: 1054-1333
Range on HMM: 3-288/297.0
IEDFADHVRLMSADSdfrFSEEYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRD
||.. ..|. .        |.||  .||  |   . ||.|. |  |||.|..  ||..||.|.. .. |  ||||||.| |.  .. |||.||||. | .
ieelvayvkekgkrG...lskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvs

HFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSgpDGRVTRFVRHWHYMAWPDFGAPSHPNGIIQ
 ||.| |||..  |.  |..||.|| || ||||..|.    .||..|. |  .| .....| . ....  . . .| | |. ...|||.| ||  . ...
dfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknv..kteesrkvthfqflsWPdyGvPssaaslld

FSRMFRHHL-----------PHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQ
. .. |..               |.. | .||||||.||.||||..|  |.     . .||. ||  .|  |  ..| ..|| | . ..|.
vlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1054-1355 4.3e-51 168.7 In-house 4-299 (439) alignment
Range on Protein: 1054-1355
Range on HMM: 4-299/439.0
IEDFADHVRLMSADSDFRFSEEYDMMRNVGVGQSVAASEL--PINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTT
 ..| .||  .  . .  |.|.....  .    .. || .    ...|||. .. ..||.|| | .   .    ||||||. |.   . .||.|||   |
rdefqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkket

RDHFWQMTWEQQCPAIIALTKCVEKGRdkchqYWPDHENvpVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDGRVTRFVRHWHYMAWPDFGAPSHPNGI
 |.||.. .|...  |. ||. ||  .     |||  ..  | |||| | .  . |. ..||| ... .    ..  | | ..||.||||   |..   .
tddfwrlviekktvtivmltnlvesyk.....ywpsdae..vcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashv

IQFSRMFRHHlPHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQGSSPSPTSTSTGAHH
..| |        .    | .|||||||||.|| |..|  |.     . .|. | |  .| .| ||||.  ||.||. ..|. ..    . |      . 
ldflrainsa.ndkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkkef

NAGF
||||
nagf

0040438 (Phosphotyrosine protein) phosphatases II 1055-1336 6.1e-92 303.5 In-house 3-277 (317) alignment
Range on Protein: 1055-1336
Range on HMM: 3-277/317.0
EDFADHVRLMSADSDFRFSEEYDMMRNVGVGqSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDH
.|. ... .. . .  ...||. ..... .  .   .||| |..|||...|. |||||||||....... |||||.||.|.. .|.|||.||||| | ..
ldlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntved

FWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDheNVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSgpDGRVTRFVRHWHYMAWPDFGAPSHPNGIIQF
||.| |||..  |. ||...|.|| ||.||||.  . .. |||. ||.. |.| .....| ...|..  ..  .|.|.|.||..|||.|.|..|. ...|
FwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedl..gdsesrtvthfhytgWpdhgvppspdllldf

SRMFRHHLPhsPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQ
 .. |..|.  ... |..|||||||||.|||| ....|.    .  .||. .|.|.|  |...||...||.|.....|. |.
leavreale..dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylk

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1056-1344 1.8e-60 199.7 In-house 9-298 (325) alignment
Range on Protein: 1056-1344
Range on HMM: 9-298/325.0
DFADHVRLMSADSDFRFSEEYDMMRNVGvGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHF
.. .||    |. .  |. |.... ... |..  .. .| |. |||| |. ..|.||| |   ..    |||||.|.  .  .  |.||| ||..| . .
nlvehvekkkaqdqdgfahefgllpsdd.giakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindl

WQMTWEQQCPAIIaLTKCVEKGRDKCHQYWPDHENVPVLYGDIEVTIVAEKEFDEFVIRDirLEKSGPDGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFS
|..  . .|. .. ..  ...| |.| .|||..    . .| .|| ... .|. ..| |   |.  ....  || |. .....|.|.| . .|  .| . 
WrlvldWrcsvvv.vlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrv..ldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisil

RMFRHHLP----HSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVL-QGSSPSPTS
..  .        .   .| .|||||||||.|.|||.  .|.       .|.|| |  .| .| .||.   |||.|. .. ...  | .  | |
qlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvs

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1058-1337 1.2e-73 243.0 In-house 15-292 (298) alignment
Range on Protein: 1058-1337
Range on HMM: 15-292/298.0
ADHVRLMSADSDFRFSEEYDMMRNVGV---GQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDH
   .  . . .  ....|.  ...|      ..  ... | |. |||...| ..|.||| |.. .. | .||||| .. ... |  |||.|.||..|   
qklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetved

FWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENvpVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDgrVTRFVRHWHYMAWPDFGAPSHPNGIIQF
||.| .|..  .|. ||. .|... |.|.||||...    ||.|.|.. ...|| ....| . ..|.  .   .| ||. |.. ||| |.|.. . ....
FWrmvteedigtiVmltnleeldktkyhkywPdegk..etygeitvsllskeefadlivrklkvskkkee..kerevrqlhftsWpdkgvpenatsvldl

SRMFRHhLPHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQG
 |  |   ..   |.| ||.|||||||||||| || .|.       .||| .|  .| .|...|| |.||.||.. .|..|. 
lrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealds

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1060-1336 2.2e-82 271.4 In-house 5-277 (281) alignment
Range on Protein: 1060-1336
Range on HMM: 5-277/281.0
HVRLMSADSDFRFSEEYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMT
|.. .|....  | |||. ....||...  ||. . |. |||..|| .||..|||... .. .  ||||||.|||... .|.||.|||.|.. ..|||| 
hlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmv

WEQQCPAIIALTKCVEKGRDKCHQYWPdHENVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDgrvTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFR
|||.  ||. .|. .|.|. |||.|||  .|  . |||. |. .||.|  ... | ..||... .   || |.. .|.|||| |.|. .. ...| .  .
weqkvsaivmvtreieagklkChrYWP.ddnselkygdvtvkstaeeekatyierkfkleresge...treveqlaytaWPdhGvPattkellefrkevl

HHlPHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSS-SFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQ
.   .. ..|| ..||||||||.||.|..|||...  .   ..||  .| |.| ||  |||   || |..  .|..|.
kl.tekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald

0036941 (Phosphotyrosine protein) phosphatases II 1063-1335 2e-89 295.1 In-house 6-277 (297) alignment
Range on Protein: 1063-1335
Range on HMM: 6-277/297.0
LMSADSDFRFSEEYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLsnPNniEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQ
|.....  ....|.. . .. .  |  ...|| |..|||...|. |||.||||  ..  || |||||.||.|..  |.|||.|||||.| ..||.| |||
lekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl..dd..egsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweq

QCPAIIALTKCVEKGRDKCHQYWPDHENVPVLYGDIEVTIVAEKE--FDEFVIRDIRLEKSGPDgrVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRH
... |. ||..||.|| ||.||||. |. .. |||. || . ...  .|....| ..... | .   .|.|.|.||. |||.|.|..|. ...| ...|.
nvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng..esrtvthfhytgwpdhgvpespaslldfielvrk

HLPHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSS---FGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVL
.|...| . |..|||||||||||||| .| .||          .|.. .|...|  |...||...||.|.....|. |
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell

0047943 (Phosphotyrosine protein) phosphatases II 1063-1334 4.4e-89 293.8 In-house 5-271 (273) alignment
Range on Protein: 1063-1334
Range on HMM: 5-271/273.0
LMSADSDFRFSEEYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLsnpnNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQ
|.....  .. ||....... .  .  ...|| |. |||...|. ||||||||    . .| |||||.||.|. . |.|||.||||| | ..||.| |||
lekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

QCPAIIALTKCVEKGRDKCHQYWPDHENV-PVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDGrvTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHH
... |. ||..||.|| ||.||||. ..  .. ||.. ||.. |...| ...| ..|...| .   .|.|.|.||. |||.|.|.... ...| .. |..
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge..srtvthfhytgwpdhgvppslesllefielvrka

LPHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQV
| ..|.| |..|||||||||.|||| .| ||.    .  .||. .|. .|  |. |||...||.|.....|  
lealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley

0045098 (Phosphotyrosine protein) phosphatases II 1066-1335 4.9e-78 257.6 In-house 3-272 (278) alignment
Range on Protein: 1066-1335
Range on HMM: 3-272/278.0
ADSDFRFSEEYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKlsnpnnieggDYINANYVPGFssRREFIAAQGPLPTTRDHFWQMTWEQQCP
|... ... |..  .  |  ...  . .. |..|||...|. |||||||          |||||.|..|.  ...|||.|||||.| ..||.| ||....
alasldlllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgit

AIIALTKCVEKGRDKCHQYWPDheNVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKS--GPDGRVTRFVRHWHYMAWPDFGAPSHP--NGIIQFSRMFRHH
.|. ||..||.|| ||.||||.  . .. |||..||.. |...|....|.....     . .  .|.|.|.||. |||.|.||.|  . .... .. |..
vivmltelvelgrekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirea

LP-----------HSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSsfGDPIDVFGTVCEMRYERCQ-MVQNEQQYIFIHYCILQVL
|            . ... |..|||||||||.||.. .. .|.    .. .|.. .|.|.|  |.. .|||..||.|.....|..|
lkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1067-1337 7.9e-70 230.7 In-house 31-294 (319) alignment
Range on Protein: 1067-1337
Range on HMM: 31-294/319.0
DSDFRFSEEYDMMRNVGVG-QSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCP
|   ..  |.  . ..||     . ..|. |. |||..|| ..|...||| . . .|. ||||| .| |. ..  .|||||||. | . ||.| ||..| 
ddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncs

AIIALTkcvekgRDKCHQYWPDHENVPVLYGDIEVTIVAEKEfdEFVIRDIRLEKSGPDgRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPHS
.|. ||      .||| |||| . ..    ....|. | | .  |.|.|||.| . |   .  | .. .|.. ||| | | .|  .... .  ||   . 
tivllt......kdkcsqywplkivikeerfkvkvdsveeta..eyvvrdielsedgke.kdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltske

PHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQ-VLQG
 |.|. .|||||||||.|..| .| ||.     . .||. .| ..| .| ..||.  || ||.  .|.  | |
nhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfg

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1067-1332 7e-37 121.9 In-house 3-256 (267) alignment
Range on Protein: 1067-1332
Range on HMM: 3-256/267.0
DSDFRFSEEYDMMRNVGVGQSVAASELPI-NRPKNRFTNIPSYDHSRVKLSNPNNIeggdYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCP
|..  . .|.......   .|  .  ..  |. .||. .   ||..|| |.. ..     |||| || |.  .. ||. |.||  |  .|...  .|..|
deeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvp

AIIALTKCvekGRDKCHQYWPDHENVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSgpdGRVTRFVRHWHYMAWpDFGAPSHPNGIIQFSRMFRHHLPHs
 |. |||    . |. ...|| .      | |. |    ||| ... |  . |.        .. |  ..|  | .  .  .|     |  . . .|   
vivlltkv...ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfk...nesahnvtlyyykkw.nintnnkpylkplfgilaknqlen.

pHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCIL
  | | .|.||.||||||||. ||  |.     .  |.|  . ..|  |  .|.  ..||.||  . 
.gnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihella

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1068-1336 1.8e-41 136.8 In-house 16-294 (301) alignment
Range on Protein: 1068-1336
Range on HMM: 16-294/301.0
SdfrFSEEYDMMRNVGVgQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNN--IEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCP
.   |.|.|. ....   .|   .    |.. ||| ||  ||. |. |.. .|  .   .||||.|. |.|....|||||||.  |   ||.. |...  
k...feeqykelkeged.ksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpv

AIIALTKCVEKGRDKCHQYWPDHENVPVLYGDIEVTIVAEKEFDEFVIRDIR--LEKSGPDGRVTRFV-----------RHWHYMAWPDFGAPSHPNGII
.|. .|.  |. ..||.||||. |.    .| ..||.| |. . .||||..   ....  .|.. | .             ..   ||. |    |. ..
sivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvL

QFSRMFRHHlPHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQ
|      |   ...  .| .||||..|.|||...|..  |        .|||. .  .|  .  .|.  .||..|.  | . ||
qviddvihr.qqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq

subfamily_PTPN6_pd Subfamily PTPN6 1071-1337 5.5e-71 234.1 In-house 27-299 (306) alignment
Range on Protein: 1071-1337
Range on HMM: 27-299/306.0
RFSEEYDMMRNVGVGQS--VAASELPINRPKNRFTNIPSYDHSRVKLSnPNNIEGGDYINANYVPG--FSSRREFIAAQGPLPTTRDHFWQMTWEQQCPA
 |.||.. ...  . .      .. | |. |||. ||  .||.||.|.  ... | |||||||. .   .|....||.|| |.||   ||.| |....  
gfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrv

IIALTKCVEKGRDKCHQYWPDHENVPVlYGDIEVTIVAEKEFDEFVIRDIRLEKSgPDGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPHSP
|. .|| ||.|..|| .||||.|. .  ||.|.|| |.||. .....|.....|   ... .| |...|. .||| | |..|. ...| .  ...  .. 
ivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskk.kkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeele

--HNAPTIVHCSAGVGRSGTFISIDRLLQ---SSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQG
  .. |..||||||.|| |||| || ||.   .. .  .||.  .|  .|  | ..|| |||| |... | . .. 
eaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1071-1336 1.8e-60 199.4 In-house 20-278 (315) alignment
Range on Protein: 1071-1336
Range on HMM: 20-278/315.0
RFSEEYDMMRNVGVGQSVAASElPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIAL
 ||||.  . .  . .  .| | .|| .|||. ||  .|..||||   ...   ||||| |.... . . .||.||||... | ||.| ....  .|. .
lfseefhdlpdPdiyrqrvare.tinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmv

TKCVEKGRDKCHQYWPDHENVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDGRVTRFvrhwHYMAWPDFGAPSHPNGIIQFSRMFRHHlpHSPHNAP
||  |  . || |||||..   | .| |.|...  .   . |.| . . ||    .||.|    ..  ||| |.. .   .... .  .    . ... .
tkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqf....qftewPdkGvdkqtssllklikevkad..ngkkefs

TIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQ
 .|||||||||.| .||||  ..    .. .||| .| ..| .| ..|| |..| ||.  .|. |.
llvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll

subfamily_CG7180_pd Subfamily CG7180 1071-1332 1.1e-51 170.3 In-house 18-287 (296) alignment
Range on Protein: 1071-1332
Range on HMM: 18-287/296.0
RFSEEYDMMRNVGVGQSVAASELpINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIAL
 .  |. .  ..  |.  .. ..  || |||  ..  ||. || |.. .  |  ||||| || .|   .|.|  ..|   | | ||.. ..... |.. |
eyklelkltprleigdCagglrk.enreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvL

TKCVEKGRdKCHQYWPDHEnvPVLYGDIEVTIVAEKEFDEFVIRDIRLEKS--------GPDGRVTRFVRHWHYMAWPD-FGAPSHPNGIIQFSRMFRHH
||  .  . ....||| .      ||.|.| || ||.. ...|| ..| |          .    || |.. ..  |.     |.  |..|.. |. |  
tktfdfak.mypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlw

LPHS---PHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCIL
  .    |...|..|..| |..||| ...||  |.  .  . .|||. |  .| .| |.|.| ..| .|   .|
rekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvll

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1071-1334 6.2e-44 145.0 In-house 21-235 (392) alignment
Range on Protein: 1071-1334
Range on HMM: 21-235/392.0
RFSEEYDMMRNVGVGQSVAAsELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIAL
 |.||.  . .  . .  .| . .|| .|||. ||  || .||||   ..|   ||.|| |.|.| . . .||.||| ... | ||.| ....  .|. .
lffeefhdlpgpdiypqtva.qkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamv

TKCVEKGrdkchqywpdhenvpvlygdievtivaekefdefvirdirleksgpDGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHlpHSPHNAP
||  |                                                 |  .| |  .|.  ||| . | | . ...| .  . .  .  .  |
tklkegd..............................................kgddartvaqfhftewPdkdvpkhtssllkfikevkad..fGqythp

TIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQV
 |.||||||||.|  |||| ..  .     .|||  | ..| .|  ||| ..|| ||. ..|. 
liihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavled

0046845 (Phosphotyrosine protein) phosphatases II 1072-1335 8.1e-90 296.3 In-house 2-274 (284) alignment
Range on Protein: 1072-1335
Range on HMM: 2-274/284.0
FSEEYDMMRNVGVGQ--SVAASELPINRPKNRFTNIPSYDHSRVKLSNPNN-IEGGDYINANYVPGF-----SSRREFIAAQGPLPTTRDHFWQMTWEQQ
. ||. ..... | .  |. .. || |. |||...|. ||||||||..... .|..|||||.||.|.      ....|||.|||||.| ..||.| |||.
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

CPAIIALTKCVEKGRDKCHQYWPDHeNVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDGrVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLP
.. |. ||..||.|| ||.||||.  . .. |||. ||.. |...| ...| ..|.. |..|  .|.|.|.||..|||.|.|..|. ...| |. |..|.
vrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytg.esrtvthfhytswpdhgvppspedlleflrlvrelle

HSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGD---PIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVL
..| . |..|||||||||.|||| .| ||.    ..    .||...|. .|  |..|||...||.|.....|  |
nlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl

DSPc_SM00195 1072-1335 2.1e-84 278.3 In-house 2-262 (263) alignment
Range on Protein: 1072-1335
Range on HMM: 2-262/263.0
FSEEYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALT
..||.. ...    ...  .| . |. |||..||. |||.||||..... || |||||||. | ......||.|||||.| ..||.| ||.... |. ||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

KCVEKGRDKCHQYWPDHENVPVLYGDIEVTIVAEKEFD-EFVIRDIRLEKSGPdgRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPHSphNAP
...|.|. ||..|||. .. .  .|.|.|..| ... . |...|...|.| |.  . ||.|....| .||| |.|.... .... |.....  .|  ..|
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgp

TIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVL
..|||||||||.|||..|| .|.. . .. .|.| .|.|.| .|..|||...||.||. .||...
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 1072-1335 2.1e-84 278.3 In-house 2-262 (263) alignment
Range on Protein: 1072-1335
Range on HMM: 2-262/263.0
FSEEYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALT
..||.. ...    ...  .| . |. |||..||. |||.||||..... || |||||||. | ......||.|||||.| ..||.| ||.... |. ||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

KCVEKGRDKCHQYWPDHENVPVLYGDIEVTIVAEKEFD-EFVIRDIRLEKSGPdgRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPHSphNAP
...|.|. ||..|||. .. .  .|.|.|..| ... . |...|...|.| |.  . ||.|....| .||| |.|.... .... |.....  .|  ..|
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgp

TIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVL
..|||||||||.|||..|| .|.. . .. .|.| .|.|.| .|..|||...||.||. .||...
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1072-1335 5.7e-60 197.8 In-house 20-276 (515) alignment
Range on Protein: 1072-1335
Range on HMM: 20-276/515.0
FSEEYDMMR-NVGVGQSVAASElpINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIAL
||||.  .       |.||  |  || .|||. ||  || .||||   |.    ||.|| |.|.| . . .||.|||.... | ||.. ....  .|. .
fseefhdlpgpniypqtvaqee..infkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamv

TKCVEKGRDKCHQYWPDHENVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPdgrvTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHlpHSPHNAP
||  |  . || .||||.    | .| |.| .|. .   . ..| ... |.      .| |  .|.  ||| |.| | . .... .  .    |.  . |
tklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd....srtvtqfhfteWPdkGvpkhtssllklikevkad..hgqythp

TIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVL
 |.|||||||| | .||||  .     .. .||| .|  .| .| ..|| ..|| ||.  .|. |
liihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1072-1336 9.2e-24 78.7 In-house 21-277 (312) alignment
Range on Protein: 1072-1336
Range on HMM: 21-277/312.0
FSEEYDMMRNVgVGQSVAASELPInRPKNRFTNIPSYDHSRVKLSNPNNIeggdYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALT
.. ||  . |. | .|  .. | . .  ||. ||  .|  |  |.  .|.    || ||.|   .    |...||||  |  ||||..    . .|| |.
ltkeykavgni.vsdsectaflkf.kdlnrypniqcwdrgrftlagdenf....yihanfvkictkperfvctqgplentcthfwqlalslgstsiillc

KCVEKGRDKCHQYWPDHEN------VPVlYGDIE-VTIVAEKEFDEFVIRDIRLEKSgPDGRVTRfVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHhlph
  || | .|| .|  |           | | .      .  |  |    | ...      |. .. . |. . .||| | |   .   ..    ..    
gfvedgsekcakyisdivgfvdledhrv.yteycteieiggkskdkithrvlkvvvk.atgqesk.lnhyqwaswpdhgmpdscdtalrllsavkk....

spHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQ
   . | | ||||||||.||.. |. .. .       .|  .   .| .|.. |.   ||..   |.|..| 
..dkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefly

subfamily_PTPN13_pd Subfamily PTPN13 1073-1336 4.1e-63 208.2 In-house 14-270 (273) alignment
Range on Protein: 1073-1336
Range on HMM: 14-270/273.0
SEEYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNpnniEGGdYINANYVP--GFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIAL
.||.. .|..   ...  ..   |. |||. |.  ||..||||..    ||| ||||...       . |.||.|||||.| . |||| |||..  |. .
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgd....egg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv

TKCVEKGRDKCHQYWPDHENVPVLYGD-IEVTIVAEKEFDEFVIRDIRLEKSgpDGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHlpHSpHNA
|. .|||. |||.|||...| ..   . .||. .  .. |.||.|.. ...|  . . .| | | ....||| | ||... ..|| .  |.   .. ...
tlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkds..esgesrevahlnfvkwPdhgvPssaaellqfvaevrrl..qt.dag

PTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQ
| .||||||.|||||.|.|| .|.  .   ..||  .| ..|  |  .|| ..||||..  ||.||.
PivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk

subfamily_ptpA1_pd Subfamily ptpA1 1073-1287 5.4e-38 125.8 In-house 24-248 (418) alignment
Range on Protein: 1073-1287
Range on HMM: 24-248/418.0
SEEYDMMRNvGVGQS-VAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSsRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALT
 ||. .. .  || |  .  .   |  |||.|||   .|.||.| . .. || |||||||. |    ..||..||||| |   ||.| ||..|  |. |.
keefrllee.svgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmls

KCVEKGRDKCHQYWPDHE---------NVPVLYGD--IEVTIVAEKEFDEFVIRDIRLEKSGPdgrvTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMF--
.  |. | || .|||..          |   ..|   .|.  | .    | . |.|||   |     || . ...|  |||.  | | . . |. .    
resencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfege....trditqyqyegwpdhnipdhtqpfrqllhsitn

--RHHLPHSPHNAPTIVHCSAGVGRSGTFIS
   . .| | .| | ||||||||||.||| .
rqnqiipssdrnvpiivhcsagvgrtgtfct

subfamily_PTPN14_pd Subfamily PTPN14 1074-1338 8.5e-52 171.0 In-house 27-299 (300) alignment
Range on Protein: 1074-1338
Range on HMM: 27-299/300.0
EEYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIeGGDYINANYVP--GFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALT
 ||. . .      . ...|| | .|||| ..  |...||.||  ..    .||||  .     ...|..|.|||||..|   |||| |||.   |. ||
teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlt

KCVEKGRDKCHQYWPDH--ENVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSgPdGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFR---HHLPHSP
.  |.|..|...|.|..  ..  | .|  .||    .. | .. . ..|.   |  .  | | |  |. ||| | |. ..| ... ....   ..  .. 
eeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhl.p.skeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnsev

----HNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQGS
    .. | .|||||||||.|  |  | |...   .. ||.  ..  .|  |  .||.  || |..  ... |. |
eskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkns

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1074-1254 2.5e-33 110.2 In-house 11-189 (297) alignment
Range on Protein: 1074-1254
Range on HMM: 11-189/297.0
EEYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNpnNIEGGDYINANYV--PGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALT
.|.|.. .   |.| ...  .    |||...| ..| .|||| .   | . |||||.||  |   .   .| ||||| .| | ||.. .||.  .|. ..
aekdllldeargesfssakrnsslrknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmva

KCVEKGRDKCHQYWPDHENVPVLYGDIEVTIVAE--KEFDEFVIRDIRLEKSgpdgRVTRFVRHWHYMAWPDFGAPSHPNGIIQF
|  | |||||  |||. ..     ||. |  ...   |||  .. ...|         .| |||  ...||| | ||  . . .|
klqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyr....sesrvvrhvqflswpdhGvpsdledlvrf

subfamily_PTPN3_pd Subfamily PTPN3 1075-1336 2.5e-66 218.4 In-house 20-276 (280) alignment
Range on Protein: 1075-1336
Range on HMM: 20-276/280.0
EYDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNieggDYINANYV----PGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIAL
.....     | .. |. .| | .|||. .| .||. ||||.. ..    ||||||||    |. .    .||.||||..|  .||||.|||..  |. |
qfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivml

TKCVEKGRDKCHQYWPDHENVpVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGpdGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHlpHSPHNAP
|  ||.|| |||||||..|.  . ||...|..  |.|  ..|.|.. |...    .  | . .  |.|||| | |.... ...| .  |.   .| .. |
ttlverGrvkChqyWPetede.leygefsvkcekedetksyvlrelvlkdke..tkeerkilqlqylaWpdhgvPddsadflefvervrkl..rsgkeeP

TIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQ
..||||||.||.| .| ..  |.     .|. .   | .||  |  .||...|| |.  .||.| .
vvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvye

subfamily_PTPN1_pd Subfamily PTPN1 1076-1333 3.8e-67 221.0 In-house 12-269 (290) alignment
Range on Protein: 1076-1333
Range on HMM: 12-269/290.0
YDMMRNVGVGQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNieggDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVE
|  .|.     ......|| ||..||. ..  |||||.|| . .|    |||||. |     .|..| .||||| | |||||| |||.. |.. | |.||
yldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvve

KGRDKCHQYWPDHENVPVLY-G--DIEVTIVAEKEFDEFVIRDIRLEKSgpDGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPHSPHNAPTI
|.. ||.|||| .|..  |      ..|....|.. .....| ..||.     . || . |.||..||||| |. |.  ..|    |.    |..  |..
keqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenl..ktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpav

VHCSAGVGRSGTFISIDRLLQS-SSFGD--PIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQ
.|||||.||||||. .| .|      .|   .|.  ...|.|  |  ..|  .|  | .  ||.
ihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1076-1335 4.9e-49 161.7 In-house 12-267 (283) alignment
Range on Protein: 1076-1335
Range on HMM: 12-267/283.0
YDMMRNVGVGQSVAASE-LPINRPKNRFTNIPSYDHSRVKLSNPNNieggDYINANYVP---GFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALT
........| .  |  .    |..|||. .| ..|  ||.| . ..    ||||| ..|        ...|.||.||  |.  ||.| ....  ||. ||
revlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmlt

KCVEKGRDKCHQYWPDHENvpVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPdGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPHspHNAPT
|  |  | || |||| .    . ||.  ||.  |   . |.|. . | ...   . | .. |. .  | ..|  .  | ...| ..      .  ...| 
klqedlrikCsqyWPkrGs..edyGeftvtlrkettsnsfiikelllrvnss.akstlllahyqvidWleygeqaiinslvkfnkvislqtes..kkgPi

IVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCIL-QVL
.||||.|.||...||..   ..       .||| .|  || .|  .||. .|| ..|  .| | |
vvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqal

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1077-1249 8.4e-07 22.0 In-house 9-158 (169) alignment
Range on Protein: 1077-1249
Range on HMM: 9-158/169.0
DMMRNVGVGQSvaASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINAnyvpgfssrrefiaaqgplpttrdhfwQMTWEQQCPAIIALTKCvek
..|. .   .    .|| .|  ||| .   .  | ||||    .  | |||||                           .| || .   |. |  .   
efmktieynnf..maeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdt...

grDKCHQYWPDHENVP----VLYGDIEV--TIVAEKEFD-----EFVIRDIRLEKSGPDGRVTRFVRHWHYMAWPDFGAPSHPN
  |   ..||..|.      |. |.       |    ..        . .. | .   |  ||. .. .|| .||. | |  | 
..ddknnfwpekedyqlhpavilGewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspv

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1077-1248 1.3e-06 21.4 In-house 10-158 (169) alignment
Range on Protein: 1077-1248
Range on HMM: 10-158/169.0
DMMRNVGVGQSvaASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINAnyvpgfssrrefiaaqgplpttrdhfwQMTWEQQCPAIIALTKCvek
..|. .   .    .|| .|  ||| .   .  | ||||    .  | |||||                           .| || .   |. |  .   
efmktieynnf..maeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdt...

grDKCHQYWPDHENVPVlygdIEVTIVAEKEFDEFVIRDIRLEK--SG-------------PDGRVTRFVRHWHYMAWPDFGAPSHP
  |   ..||..|.  .        |. |   | . .|  ....  ||              |  ||  .. .|| .||. | |  |
..ddknnfwpekedyql....hpavilgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqsp

subfamily_PTPRN_pd Subfamily PTPRN 1078-1333 1.7e-48 159.8 In-house 37-290 (297) alignment
Range on Protein: 1078-1333
Range on HMM: 37-290/297.0
MMRNVGVGQSVA-ASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRR-EFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVE
 . .    .|.. ... . |  ||| ... .||||||||.. .. |  |||||  .     |.  .||.||||..|  .|||| ||| .  |..||.  |
alcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrlee

KGRDKCHQYWPDHENvpVLYGDIEVTIVAEKEF-DEFVIRDIRLEKSgpDGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHlpHSPHNAPTIVH
.|  .|..||||. .   .|.  || .|.|. . |....| . |     . . || |  .|...||. |.|. .. ...| |       .    .| .||
egvkqckrywpdeGs..evyhiyevhlvsehiwcddylvrsfylknl..qtsetrtvtqfhflswpeegvPasaksllefrrkvnks..yrGrscpivvh

CSAGVGRSGTFISIDRLLQSSSFG-DPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQ
||.|.||.|..| || .|.    |   ||.  |.  .| .| ..|. ..|. |.  .. .
csdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1080-1337 4e-68 225.0 In-house 8-258 (284) alignment
Range on Protein: 1080-1337
Range on HMM: 8-258/284.0
RNVGV-GQSVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTkcvekgR
 ..|| |   . ..|. |. |||...| ..|...||| .   .|. ||||| .. |. ..  .||.||||. | . ||.| ||..| .|. ||      .
cklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......k

DKCHQYWPDHENVPVLYGDIEVTIVAEKEfdEFVIRDIRLEKSGPDgRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPHSPHNAPTIVHCSAG
||| |||| . ..    ....|. | | |  |.|.|||.| . |   .  | .| .|.. ||| | | .|  .... .  ||   .  |.|. .||||||
dkcsqywplkivikeerfkvkvdsveese..eyvvrdielsedgke.kdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsag

VGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQ-VLQG
|||.|..| .| ||.     . .||. .| ..| .| ..||.  || ||.  .|.  | |
vgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfg

subfamily_PTPN23_pd Subfamily PTPN23 1085-1333 1.3e-54 180.0 In-house 34-278 (288) alignment
Range on Protein: 1085-1333
Range on HMM: 34-278/288.0
GQSVAASELpiNRPKNRFTNIPSYDHSRVKLSnpnnIEGGDYINANYVPGFSSR-REFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQ
..|.|...|  .  |||...|  |||.||||      .  ||||| .| . |.   .|||.|.||..|   ||.| .||. . |. |..  |.|. |...
krsiaiakl..yseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdr

YWPDHENVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDgrVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRH--HLPHSPHNAPTIVHCSAGVGR
||| ... .| .||..||.  ..| ...| |...||  ..|   .. |.| ....||..|.|. |. ..||    ..  .  . . ..| .|||||||||
YwPedkgetvkfgdlsvtlksvretethvervlkletldad..avksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgR

SGTFISIDRLLQSSSFGDPI-DVFGTVCEMRYERCQMVQNEQQYIFIHYCILQ
.|.|  .   ..  . |. . |.   |  .| .|  |||...|. |    .|.
tgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle

0049772 (Phosphotyrosine protein) phosphatases II 1086-1336 8.4e-42 139.3 In-house 36-281 (314) alignment
Range on Protein: 1086-1336
Range on HMM: 36-281/314.0
QSVAASELPINRPKNRFTNIPSYDhSRVKLsNPNNIEGGDYINANYVPGFssrREFIAAQGPLPTTRDHF----------WQMT--WEQQCPAIIA----
... .. |. || |||...|. .| .||.| .  ...| |||||.|| ||   . |||.||||. | . |          |.|.  .....  |      
ltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrde

-----------------LTKCVEKGRDKCHQYWPDHEnvpvlygdievtivaekefdefvirdirlEKSGPDGRVTRFVRHWHYMAWPDFGAPsHPNGII
                 |... ..|   . .......                             |   .. ...| . ..... .||..||  .. . 
vladelsrLdaAlgKtpllildgngneptaadlellk.............................eelydpelferlgikylripvpDgsap.lledfd

QFSRMFRHHlphsPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFgDPIDVFGTVCEMRYeRC---QMVQNEQQYIFIHYCILQVLQ
.| .... .    . . |..|||.||.||.|||. .. |.    . .. ...  | ..|.  .    .... .||.||....|. |.
eflefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRp.inpnpgfieqleqyefilealleylk

subfamily_CG42327_pd Subfamily CG42327 1086-1253 4.8e-27 89.4 In-house 16-185 (319) alignment
Range on Protein: 1086-1253
Range on HMM: 16-185/319.0
QSVAAS-ELPI-NRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFS-SRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCH
| .| . |.|.  ..|.|. |.    ..|| | .  . .   |..|.|| |.  ..  .|||| .|  .   ||.. ||||   |. ||.  |.| ..| 
qliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvca

QYWPDHENVP--VLYGDIEVTIVAEKEFDEFVIRDIRLEKSgpDGRVTRFVRHWHYmAWPDFGAPSHPNGIIQ
.|.| .|  .   ||||| ||.   .  |...|  . | .   |.  .| . |. |  |.. . |.... .| 
eylPtketldntslyGdilvtlkgrevkdryaistlllkrv..dkeesrelthywy.kwleaevPaeeaalia

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1087-1333 7.4e-41 135.1 In-house 32-275 (307) alignment
Range on Protein: 1087-1333
Range on HMM: 32-275/307.0
SVAASELPINRPKNRFTNIPSYDHSRVKLSNPNNieGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWP
.|..  .  |  |||.....  |..|. .  .      ||| |||.      . ||.||||| .|. .|| |. ...  ..| | |..| .. ||.||||
gvtveafsantdknryqdvkcqdkgrivvkfdgl..asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywp

DHENVPVLYGDIEVTIVA------EKEFDEFVIRDIRLEKSGpdGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHhlphspHNAPTIVHCSAGVG
  |     .|.   ||        .   || .|    |.     .. .| ..|. .  ||| |.|    . | .    |       .. | .||||||||
leegqklvfgeapntisvanlgakklapdedlinvttlkvdw..aqksrtiqhlqwenwpdrgvpqinltainlleavry......dtnpvvvhcsaGvG

RSGTFISIDRLLQSSSFGDP-IDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQ
|||| ..|  . .    |    |.   | |.| .|   .|.| ||...|  .|.
rsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1087-1333 6.2e-39 128.3 In-house 28-267 (281) alignment
Range on Protein: 1087-1333
Range on HMM: 28-267/281.0
SVAASELPINRPKNRFTNIPSYDHSRVKLSN-PNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYW
 ... . |.|  |||..|||  | |||.|     | .  ||| |||.     .| .| .|||   ||  ||.| |...  ||. | . .|  |.|| .|.
lctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyf

PDHENVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGpdgrVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHhlphspHNAPTIVHCSAGVGRSGTF
|    . . .  . |.         .|   . |   |     ||.. || .  |||.  |   . ...  |  |       . .| ..|||||||||||.
prnahcclqfdklsvsyedstvnkslvttrlnlsyeg....etrlithwlwkewpdwqvpessevmlkilrkira......rstppvihcsagvgrsgtl

ISIDRLLQS--SSFGDPiDVFGTVCEMRY-ERCQMVQNEQQYIFIHYCILQ
....  |||  | |  | |.   |  .|   |.  ||  |||..|   .|.
maveialqsihshftlp.dikqivshlrvtgraasvqtlqqymliwkvlld

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1087-1331 9.7e-18 58.8 In-house 38-275 (303) alignment
Range on Protein: 1087-1331
Range on HMM: 38-275/303.0
SVAASELPINRPKNRFTNIPSYDHSRVKLSNpnniegGDYINANYVPgFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWP
||.  ..  |  ||||...   |||.||||.        || |.|.  . |..  | .| ||. |   ||||  ||.   .. |    |  .   .  .|
svsknqfvknmdknrfvdvicldhskvklsd......ssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfp

DHENVpvLygDIEVTIVAEKEFDEFVIRDIRLEK--SGPDGRVTRFVRHWHYMAWPDFGAPSH--PNGIIQFSRMfRHHLPHSPHNAPTIVHCSAGVGRS
  ..   |  ..|   .   || .  . |    |  |  .|    |.   || |||    ||.  |. . |  .. .  | .  .. ||.    .|.||.
rnqdf..l..kfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwql.qsvlrkysdstptvymslsgcgra

GTFISIDRLLQS-SSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCI
|||  ..    |  |    .|.   .  .|  | . |||  |. ...  .
gtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytll

subfamily_PTPN12_pd Subfamily PTPN12 1089-1336 5.5e-71 233.8 In-house 33-278 (290) alignment
Range on Protein: 1089-1336
Range on HMM: 33-278/290.0
AASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDH
.|.| . |. |||. .|  ||.|||.||. .. || ||||||.. | ... |.||||||||.| | ||.| ||..   .. . . || |. ||..|||..
eagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpee

ENVPVLYGDIEVTIVAEKEFD-EFVIRDIRLEKSgpdgRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPhsPHNAPTIVHCSAGVGRSGTFIS
 . .. .|..|||  .|| .| .|.|| ...|..    . .| |. .||.|||| | || .. .... ...|..     ..|| .||||||||| || |.
geeelefgefevtleeekavdddflirtLkveaq....kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGrtGtiia

ID---RLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQ
||   .||..    . .|||  | |.| .|  .|| ..|| ... ......|
idyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq

0040439 (Phosphotyrosine protein) phosphatases II 1090-1334 3.2e-79 261.3 In-house 5-245 (249) alignment
Range on Protein: 1090-1334
Range on HMM: 5-245/249.0
ASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDhe
 ..|| |..|||...|. |||||||||  .. ...|||||.|..|. . |.|||.||||| | ..||.| ||... .|. ||..||.|| ||.||||.  
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..

NVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSgpDGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPHSPHNAPTIVHCSAGVGRSGTFISID
. .. |||. || . ....|....| ..|...      .| |.|..|  |||.|.|.... ...| .. |..| . | . |..|||||||||.|||| ..
ggsleygdftvtllsvevkddytvrtleltnl..ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaay

RLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQV
 .|.       .|.. .|...|  |...|||..||.|.....|. 
lmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1090-1333 1.6e-62 206.1 In-house 22-266 (274) alignment
Range on Protein: 1090-1333
Range on HMM: 22-266/274.0
ASELPINRPKNRFTNIPSYDHSRVKLSNPNNIEG-GDYINANYVPGFSSR-REFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPD
  ... .  |||...|   ..||| |.. .. .   .||||||. |.. . . ..|.|||||.| . ||.| ...... |. |||  |. ..||..|.||
eldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPd

HENV--PVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPdgrvTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPH-SPHNAPTIVHCSAGVGRSGT
.|..     |||.|....  .| ... .| . |...      .| | |. | .|||  .| ..| .... .  ..   . . . ||..||||||.|| | 
aedyeiserygdveikvekiverndysvrklvlkyler....ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGc

FISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQ
||.|.  ..       .||...||..| .|  |||...|| .||  . .
fiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl

0037934 (Phosphotyrosine protein) phosphatases II 1091-1333 6.7e-73 240.5 In-house 5-240 (243) alignment
Range on Protein: 1091-1333
Range on HMM: 5-240/243.0
SELPINRPKNRFTNIPSYDHSRVKLsnpnniEGGDYINANYVPGFssRReFIAAQGPLPTTRDH----FWQMTWEQQCPAIIALTKCVEKGRDKCHQYWP
. || |..|||...|. ||||||||      ||.||||||.....  .| .|| ||||| | ..    ||.| ||... .|. ||..||.|| ||.||||
allpenlsknrysdilpydhsrvkl......egsdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

dhENVpvLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDGRVtRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPH------SPHNAPTIVHCSAGVG
  ..|   |||..||.. |...|....| ..||  ..|. . |.|.|.||..|||.|.|..|. ...| .. | ..         ... |..||||||||
..gev..tygdftvtllseehlddytvrtlllenldlddlt.rlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RSGTFISIDRLLQSSsfgDpIDVFGTVCEMRYERCQ-MVQNEQQYIFIHYCILQ
|.||.| .. .|.     . .|.. .|...|  |.. .||...||.|.....|.
RtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle

0042113 (Phosphotyrosine protein) phosphatases II 1092-1335 2.1e-77 255.1 In-house 5-243 (245) alignment
Range on Protein: 1092-1335
Range on HMM: 5-243/245.0
ELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDheNV
.|| |..|||...|. |||.|||||.... .. |||||.||.|.   . |||.||||| | ..||.| ||... .|. ||...|.|| ||.||||.  . 
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..ge

PVLYGDIEVTIVAEKEFDEFVIRDIRLEKSgpDGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPHsPHNAPTIVHCSAGVGRSGTFISIDRL
.. |||. || . |. .|....| .....       .|.|.|.||. |||.|.|.... ...| .. |..|   . | |..|||||||||.|||| ....
sltygdftvtllseehlddytvrtlevtnl..gddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylm

LQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVL
|.       .... .| |.|  |...||...||.|.....|. |
leqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1092-1337 1.7e-66 219.0 In-house 5-244 (250) alignment
Range on Protein: 1092-1337
Range on HMM: 5-244/250.0
ELPINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDkCHQYWP-DHen
. | |. |||...| ..|.||| | . .  .  ||||| .. |.. |. |||.||||..|  .||.| .|..  .|. ||. .|...  .||||| ..  
kkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek..

vPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDGrvTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPHSpHNAPTIVHCSAGVGRSGTFISIDR
 .  |||. |..  ..|| ....| . | |    .   | ||. |...||| | | . . .... .  .   ... .||| ||.|||||||||.|| || 
.aekyGdvtvsllskeefadytkrklklskakkad..erivrqlhfvvWPdkgvPevatavLellkkvqasqqqa.gnaPvivqCsaGvgrsGafiaida

LLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQG
.|.       .|||  .  .| .| ..|. ..||.|..  ||. |. 
vlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1092-1335 3.2e-35 116.3 In-house 44-287 (305) alignment
Range on Protein: 1092-1335
Range on HMM: 44-287/305.0
ELPINRPKNRFTNIPSYDHSRVKLSNPNNiegGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENV
    .. |||. ..   |. |||| .|      .|| ||||   .  . || .| ||  |   || | ....  ||. | . .|||  ||..|.. ... 
keaqeagknrykdvgcldnnrvklegpwp...heyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkd

PVLYG--DIEVTIVAEK----EF---DEFVIRDIRLEKSGPdGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRhhlphsPHNAPTIVHCSAGVGRS
 . .   .  ...  |     .|    . ....  |   || |  .| | |.|.. ||| | |.  . |...    |      |   |..||||||.||.
vlefeekgqkisvkfessvtlkfrkdakakvtetvlviegp.gekarkvthyhwidwpdrgvpaadlailellekar......pskgpivvhcsagigrt

GTFISIDRLLQSSSFGDPIDVFGT-VCEMRYERCQMVQNEQQYIFIHYCILQVL
|. . .. .|.    |. |.     .  .| .| . .| ..||.|.|  ||. .
gsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1092-1170 4.2e-06 20.5 In-house 33-116 (347) alignment
Range on Protein: 1092-1170
Range on HMM: 33-116/347.0
ELPINRPKNRFTNIPSYDHSRVKLSnPNNIEGG------DYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIAL
|   .  |||  .    | .|| || |.. . .       |||| ..    ...|.| .| ||| |   ||.|    .   ....
ewekslsknrskdvklidatrvvls.peksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1093-1333 5.3e-36 118.8 In-house 52-287 (305) alignment
Range on Protein: 1093-1333
Range on HMM: 52-287/305.0
LPINRPKNRFTNIPSYDHSRVKLSNPNnieGGDYINANYVPG-FSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDH--E
  |.  |||....|  |.| |||..|.     ||| ||||   .   . ||.|||||  | |.|| |  ...   |. | | || |. || ||||    |
adiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqge

NVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHhlphspHNAPTIVHCSAGVGRSGTFISID
.. .  | .   .   | ..     .| | .    |  .  ||| ..  ||| | |      ...    |        . | .||||||.||.|| ..|.
klelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairg......skvpivvhcsagigrtgtivaie

RLLQSSSFGDPIDVF-GTVCEMRYERCQMVQNEQQYIFIHYCILQ
 .|.  .   |   .   |  .| .|.  .||. ||.|||  .|.
yilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1094-1332 7.2e-50 164.4 In-house 6-238 (239) alignment
Range on Protein: 1094-1332
Range on HMM: 6-238/239.0
PINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFS-SRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENvp
 .|. |||..|| .|||||| | . .|    |||||.|.  .  | . .||.|| . ..   ||.| |...   |. ||  .|  . ||||||||  .  
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..

vLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDgrVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHlpHSPHNAPTIVHCSAGVGRSGTFISIDRLL
  | .. ||.   . | ...|| . . . |      |.| ..|.  ||| | | .   .. . |   .     |   | ..||||||||.|.|. || .|
.kycnlrvtlrktevfadyiirtfvmsqvgqt..eeryvyqyhftvwpdkgvpqyatavlglrrkitkd..slpgarpwvihcsagvgrtgaflvidaml

QSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCIL
. .     .|.|  |  .| .| .|||  .||.||| ..|
rqakkqktvdifnyvkairedrphmvqtseqyvfihlavl

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1094-1327 1.3e-28 94.6 In-house 48-273 (301) alignment
Range on Protein: 1094-1327
Range on HMM: 48-273/301.0
PINRPKNRFTNIPSYDHSRVKLS-NPNNIEggdyINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENVP
 ... |.|. ..|   .. |..  . . .     | ||..|     . |||.||||. |.. || |    .   |. |.. |||  .||..| | . .  
ylpkdkhryptvPckPstavevivdGkrvP....ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisek

VLYGDIEVTIVAEKEF--DEFVIRDIRLEKSGPDgRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHhlphSphNAPTIVHCSAGVGRSGTFISIDR
.  |  ...|. ..    .. . | ...| |  .   || | |. |. |.| | |     . ..  . ..    |  . | .||||||.||| .||. . 
ldigrfkikiknkelilnkkiskrtlevedstgk.fatrtvthyqysewtdrgvPkshaelfdlmelvkk....s..ekPivvhcsaGiGrsvafigtey

LLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFI
| .       |..  .. ..| .| . ||...|  ..
lareveadptieltealkhlrehrwngvqtnsqlywm

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1095-1331 2.9e-50 165.7 In-house 37-273 (287) alignment
Range on Protein: 1095-1331
Range on HMM: 37-273/287.0
INRPKNRFTNIPSYDHSRVKLSNPNNiEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHeNVPVL
 .  |||....  .|..|| ||.  .  | ||||||||...    .|||||||...|   ||.. .|..  ..| .|. ||..| ||..|||.. .||..
aavkknryadvlPiddtrvllsaege.lGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmr

YGDIEVTIVAEKEF-DEFVIRDIRLEKSgpDGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPH---SPHNAPTIVHCSAGVGRSGTFISIDR
 |   |...  .    |. .| .|| .   ..| .| |.  ....||| ...    |.|.|    ..|.     .    | .||...|.||||.....  
vGGysvvlldydikePeygvralrlidl..etrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlv

LLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCI
|..       .||  .|  .|  |  .||   |. ..   .
lvsrledlGrvdvaavvirlreyraalvqavvqlrllyeal

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1095-1333 6.2e-50 164.6 In-house 6-238 (239) alignment
Range on Protein: 1095-1333
Range on HMM: 6-238/239.0
INRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFS-SRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENvpv
.|. |||..|| .|||||| | . .|    |||||.|.  .  | . .||.|| . ..   ||.| |...   |. ||  .|  . ||||||||  .   
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts...

LYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDgrVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHlpHSPHNAPTIVHCSAGVGRSGTFISIDRLLQ
 | .. ||.   . | ...|| . . . |      |.| ..|.  ||| | | .   .. . |   .     |   | ..||||||||.|.|. || .|.
kycnlrvtlrktevfadyiirtfvmsqvgqt..eeryvyqyhftvwpdkgvpqyatavlglrrkitkd..slpgarpwvihcsagvgrtgaflvidamlr

SSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQ
 .     .|.|  |  .| .| .|||  .||.||| ..|.
qakkqktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_egg_pd Subfamily egg 1095-1334 9e-32 105.0 In-house 39-269 (307) alignment
Range on Protein: 1095-1334
Range on HMM: 39-269/307.0
INRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKgrDKCHQYWPDHENVPVL
 |. | |   ..  | |||||  ..    .|.| ||.| |     ||| || ||  | | ||.| ...... |. ||  .|   ..|. |||  |. .. 
nnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslv

Y--GDIEVTIVA--EKEFDEFVIRDIRLekSGPDgRVTRFVRHWHYmAWPDFGAPSHPNGIIqfsRMFRHHlphsphNAPTIVHCSAGVGRSGTFISIDR
.  | .... .   .|    | .  ..|   |.| .  ||. || .  .   .    |  ..   |. |.         |..|..  || ...|...|. 
tvpGslrienlkvdskadplfrvtklkl..vGgd.deerflehwqg.dvnnssdvysplrvl...rklrnl......skpvvvqdilGvskaatlvaiei

LLQSSSFGdPID---VFGTVCEMRYERCQMVQNEQQYIFIHYCILQV
 | |   | ||    |  .|  .| .|   |.   .|.|..  .| .
allsllrG.pitkslvlravvflrlrrrlsvesvllylfvyrlvlff

Y_phosphatase Protein-tyrosine phosphatase 1096-1332 1.3e-78 259.0 Pfam-A 1-234 (235) alignment
Range on Protein: 1096-1332
Range on HMM: 1-234/235.0
NRPKNRFTNIPSYDHSRVKLsnpNNIEG-GDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENVPVL
|. |||...|. ||..||||   .. ||  |||||||| |... ..|||.||||. | ..||.| |.... .|. ||...|||| ||.||||..|. .. 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGDIEVTIV-AEK-EFDEFVIRDIRLEKSGPDGrVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLphSPHNAPTIVHCSAGVGRSGTFISIDRLL
||||.|...  || . .|...|...|.|.. .   .| |...|| .||| |.|..|...... |.....   .....|..|||||||||.|||...| ||
ygdikvelkekekedekeytlrklelkkkkees.ekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldill

QSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCIL
.. . .. .||. .|.|.| .|..|||...||||.. .||
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 1096-1332 1.3e-78 259.0 In-house 1-234 (235) alignment
Range on Protein: 1096-1332
Range on HMM: 1-234/235.0
NRPKNRFTNIPSYDHSRVKLsnpNNIEG-GDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENVPVL
|. |||...|. ||..||||   .. ||  |||||||| |... ..|||.||||. | ..||.| |.... .|. ||...|||| ||.||||..|. .. 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGDIEVTIV-AEK-EFDEFVIRDIRLEKSGPDGrVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLphSPHNAPTIVHCSAGVGRSGTFISIDRLL
||||.|...  || . .|...|...|.|.. .   .| |...|| .||| |.|..|...... |.....   .....|..|||||||||.|||...| ||
ygdikvelkekekedekeytlrklelkkkkees.ekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldill

QSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCIL
.. . .. .||. .|.|.| .|..|||...||||.. .||
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1096-1333 1.5e-61 202.7 In-house 20-262 (270) alignment
Range on Protein: 1096-1333
Range on HMM: 20-262/270.0
NRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYVPGFSS-RREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENV--P
..  ||...|    ..||.|.. .. .   |||||||.||.. ....|||.||||||  .||.| ||.. .||. .|. .||||.|| .||| . .    
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

VLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDgrvTRFVrHWHYMAWPDFGAPSHPN------GIIQFSRMFRHHLPHSPHNAPTIVHCSAGVGRSGTFI
. .|.|.|. ..|.  . .... .|||..|      | | |..| .||| |.|....       ...  |  |..  .  .. |..|||||||||.||.|
ledgkikvlalseekeegyiltrlrleekgee...rrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtli

SIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQ
 .|  ..  .    .||   . |.| .|...||  .|| |..  ...
alDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1096-1332 2.9e-59 195.2 In-house 3-236 (237) alignment
Range on Protein: 1096-1332
Range on HMM: 3-236/237.0
NRPKNRFTNIPSYDHSRVKLSNPNNieGGDYINANYVPGFSS-RREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHeNVPVL
|. |||. || .|||||| |  . .  | |||||.|. ||    ...||||||| .. | |||| |...|  |. ||  .|. . |||.|||.  . |  
nkiknrygnivaydhsrvvlkgags..gsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst.dqpaa

YGDIEVTIVAEKEFDEFVIRDIRLEKSGPDGrVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPHSPHNAPTIVHCSAGVGRSGTFISIDRLLQS
|| . |..  ..|| .. .| . | | .      |..  ... .||| | | .   ...| .   .. || .. .| |.||||||||.| |. || .|. 
ygvltvslkkkeefsdytvrslllskrltlk.evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq

SSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCIL
.     .|..  |  .  .|  ..| ..||.|||  ||
akekkvvdiynyvysieedrpyiiqtkdqyvfihqtil

0041856 (Phosphotyrosine protein) phosphatases II 1096-1336 5.5e-48 158.3 In-house 1-172 (182) alignment
Range on Protein: 1096-1336
Range on HMM: 1-172/182.0
NRPKNRFTNIPSYDHSRvklsnpnnieGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTkcvekgrdkCHQYWPDHEnvpvly
|..|||...|. |||||          . ||||||.. |    ..|||.||||. |  .|..| .|... .|. ||         ...|||...      
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

gdievtivaekefdefvirdirleksgpdgrvTRFVRHWHYMAWPDFGAPShPNGIIQFSRMFRHhlphspHNAPTIVHCSAGVGRSGTFISIDRLLQSs
                                .| . ...|. |||.|.|. .. ...| .. ..      .. |..|||||||||.||.. .. ...  
................................erlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaaylmkkl.

sfgdPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQ
     .... .|...|  |..||....||.|.....|..|.
....gvsleeavklvrsrRpgmvitpnqyfflqlallelll

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1096-1335 1.1e-33 111.6 In-house 43-271 (288) alignment
Range on Protein: 1096-1335
Range on HMM: 43-271/288.0
NRPKNRFTNIPSYDHSRVKLSnpnnIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENVPVLY
|  ..|..|.|  | .|||||     .   ||.|| |.    .| .| || || .| . .|.|  |..   |. |.. .|||..|  .|.| .    . .
nptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

GDIeVTIVAEKEFDEFVIRDIRLEKSGPDGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFrhhlphSPHNAPTIVHCSAGVGRSGTFISIDRLLQSS
| .  |.| .|  |   .  . | .    |  . .|.. |.  |.| | |      ...  ..        .. | .||.||||||.||.| |   |.| 
grl.ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl......kslqkPivvhssaGvGrtgtlililialesl

SFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVL
   | . .   . ..| || . .| |.||...| |.|. |
rlddflgirsllaklreerfkaiqtemqylyvhrcvleel

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1096-1335 9.9e-28 91.9 In-house 35-270 (285) alignment
Range on Protein: 1096-1335
Range on HMM: 35-270/285.0
NRPKNRFTNIPSYDHSRVKLSNPNNieggDYINANYV--PGfSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENVPV
|   ||....   . .|| | | .     ||| |...  ||   .  .|..||||| |   ||.| ....   .. |   .| | .||  |.|..    |
npdlnryadvrcieetrvvlknhdr....dyihaswmrmpg.kdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevv

LYGDIEVTIVAEKE--FDEFVIRDIRLEKSGPDGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHhlpHSPHNAPTIVHCSAGVGRSGTFISIDRL
 .|  |.|.   ||      ..  . . ..        .. | .   |||  ||     .|.. .  ..     |.. |  |||||||||. ||. ||  
kfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkk...vnpkekpicvhcsagvgrtatfvgidya

LQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVL
         |...  | |||  | | ||.  |..|..  ... .
tirimenpniemldivremramrfqavqshmqflflyvvlmeyf

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1096-1335 1.3e-14 48.3 In-house 51-285 (302) alignment
Range on Protein: 1096-1335
Range on HMM: 51-285/302.0
NRPKNRFTNIPSYDHSRVKLSNpnniEGGDYINANYV--PGFSsrREFIAAQGPLPTTR---DHFWQMTWEQQCPAIIALTKCVEKGRdKCHQYWPDHEN
|  ||. ...| .|. .|||..    |  .|.||  |  | ..  |. | || |  ..    ..||.| .....  .  | .  |  .   ....| . .
nlkknqsedvpildsnlvklea....epdsyvnaskvevPelt..rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksg

VPVLYGDIEVTIVAEKEFDEFViRDIRLEKSgPDG-RVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFrhHLPHSPHNAPTIVHCSAGVGRSGTFISID
  . ||.. | .   .. .| .     .|   |.|   . ..   .   |..   | . . .|.       .  ... ...|..    |.|| |.|..  
dykeygkmfvNnrkVekaeeek.tryviEvl.PegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv..fakkikadentvivSknGaGRagafltla

RLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVL
  ...   |.   .  .|  .| .|...|.. .||.... ..|  .
vaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1098-1333 7.4e-40 131.4 In-house 58-281 (290) alignment
Range on Protein: 1098-1333
Range on HMM: 58-281/290.0
PKNRFTNIPSYDHSRVKLSNPNNiegGDYINANYVPGFSSrrEFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENVPVLYGD
 |||. ...  | .|| |..  .   |||. |||| |  .   || .||.|  |   .|.|  ...  ||. | . .|.|. ||.||.|..|   . .|.
kknrykdvvcndktrvilkdGyd...GdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGe

IEVTIVAEKEFDEFVIRDIRLEKSGPDGRvTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHhlphspHNAPTIVHCSAGVGRSGTFISIDRLLQSSSF
| |.   |.. |. .|. .   .   .|.    ..|.. ..|||   .     ...  |. |.       . | .||||||.||.|||..|.  ||    
itvlcseeddkdaniikktlsvrdkdsGk.ehklkhlkikswpdksvalstlallrtlrilrk......asGpvvvhcsaGiGrtGtfvaievglqilld

GDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQ
|  .|. ..|  .|  | . || . ||. .   .|.
Gkeldlldlvralrnsrlnsvqvdiqylalveilld

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1098-1337 3.8e-31 102.8 In-house 54-292 (310) alignment
Range on Protein: 1098-1337
Range on HMM: 54-292/310.0
PKNRFTNIPSYDHSRVKLSNPNnIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHeNVPVLYGD
 |||....   | |||||   .    .||| ||||     |  || .||||  |   ||.| ..... .|. | | .|.|| ||  |||    |   || 
hknrysdvvcldtsrvklkidk.sryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpsl.gvtetygc

IEVTIVAEKEfDEFVIRDIRLEKS--------GPDGRVTRFVRHWHYMAWPDFGAPSHPNGIIQfSRMfrhhLPHSPHnAPTIVHCSAGVGRSGTFISID
| || ..|   .|| | .. .            |       |   ..  ||| | |      .   |.    |    |  | .||||||..| .. ....
irvtnlsess.eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp.qrl....laqvrh.gpcvvhcsagkdrlyvvvalk

RLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQG
  .. .  |. .|.   . |.. .| . .|.| ||..|..  .   .|
lkidkldrglkvdaeevktellksraiciqtelqyliidrvriifarg

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1098-1188 1.3e-14 48.4 In-house 50-156 (349) alignment
Range on Protein: 1098-1188
Range on HMM: 50-156/349.0
PKNRFTNIPSYDHSRVKLSN----PNNIE----------GGDYINANYV--PGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKC
 |||. .|  |.|||||| .    .. |.            |||||||.  . .|  . .|| | |||.| | |...   .. . ...|..  |.. .||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

HQYWPDH
..|| . 
diywqel

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1098-1181 3.6e-08 27.2 In-house 36-118 (332) alignment
Range on Protein: 1098-1181
Range on HMM: 36-118/332.0
PKNRFTNIPSYDHSRVKLSNPNNieGGDYINANYVPGFSSRREFIAAQGPLPT-TRDHFWQMTWEQQCPAIIALTKCVEKGRDKC
  ||   .  .|||||.|.  .     |. ||..| |.| .  .| || |.   |   ||.|  |..   |. .    || . |.
dmnriphlycfdhsrvelapqdg..kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1099-1188 1.1e-21 71.9 In-house 50-153 (350) alignment
Range on Protein: 1099-1188
Range on HMM: 50-153/350.0
KNRFTNIPSYDHSRVKLS--------NPNNIEGGDYINANYV--P--GFSSRREF--IAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQY
|||..||  |.||||||             ... |||||||.  .  . .   .|  ||.|.||| | | |...  . . . |..||. || ...||..|
knrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrY

WPDH
|.. 
Wqeg

subfamily_eak_pd Subfamily eak 1100-1246 1.6e-13 44.8 In-house 56-196 (332) alignment
Range on Protein: 1100-1246
Range on HMM: 56-196/332.0
NrFTNIPSYDHSRVKLSNPNnIEGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENVPVLYGDIE
|   .|  ||.  |.|..    .   ||||  .      |..| .  .  .    ||||  ||. |||. | . ||.. .|  .|.||.    . .| ..
n.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGild

VTIVAEKEFDEFVIRDIRLEKsgpdGRVTRFVRHWHYMAWPDFGAPS
|.     . . .  | . |.|    |  |  | |...  | ..  | 
verkefvkrniletrllelsk....GnethrvlhykvfGwtettlpk

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1103-1335 3.8e-15 50.8 In-house 25-259 (290) alignment
Range on Protein: 1103-1335
Range on HMM: 25-259/290.0
TNIPSYDHSRVKLSNPNNIEGGDYINANYVpGFSSRREFIAAQGPLPTT-------RDHFWQMTWEQQCPAIIALTKCVEKGRD----KCHQYWPDHENV
...|   ..|| | .  .    ||| ||.|  ...  ..|. | |.  .         .|| |  . .   .. | .  || ..     | .| |.... 
levpLveatrvvLkgygkrfnddyiHAnrv.tcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvge

PVLYGDIEVTIVAEKEFDEFVIRDIRLEKsgpDGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHhlphspHNAPTIVHCSAGVGRSGTFISIDRL
 . .....|      . |.. .| . ..    |...   | |  .  | .  .. ..  ...  .. .       ...| ||||  |. || .. .|.  
elkfkgltvkCkskekeddvetRelvvkf...ddeeeftvtHsllkgWnklnvqedtktllsliqkvka......sktpvivHcvdGiSrsAalaaiilg

LQSSS-FGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVL
 |      . . .   . ..| .| ......... |. . |.  .
yQkiaetsgsvkledvlkalrkqralaitsalelafvdagivlla

0044763 (Phosphotyrosine protein) phosphatases II 1108-1337 2.2e-34 114.0 In-house 2-173 (178) alignment
Range on Protein: 1108-1337
Range on HMM: 2-173/178.0
YDHSRVKLSNPNNIEGGDYINANYVPGFssrrEFIAAQGPlpttrDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENvpvlygdievtivaeke
.|..||.|||. ..|..|||||... ..     ......|      ..... .|. . .|. ||. .| |. ||..|||. ..                 
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

fdefvirdirleksgpdgrvtrfvRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPhsPHNAPTIVHCSAGVGRSGTFISIDRLLQSssfgdPIDVFGTV
                         ..... .||.|.|. .  . .| .. ...|.  ... |..||||||||||||.. .. ...       ....  .
........................iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeai

CEMRYERCqMVQNEQQYIFIHYCILQVLQG
 ..|  |. .|.|. |. ..... |..|. 
elvrerRp.ivpnpgqlrqLyefelrllke

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1109-1219 8.5e-10 33.0 In-house 6-103 (130) alignment
Range on Protein: 1109-1219
Range on HMM: 6-103/130.0
DHSRVKlsnpnnieGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKcVEKGrdkcHQYWPDHENVPVLYGDIEVTIVAEKEF
. ||..        | .||||..|      .|.. .| ||  |  .||.|  |.    .. |   ||.      .|||| | .     || ||.   .||
evsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgs.veee....deywpdsePlewyeediivtltdrdef

DEFVIRDIRLE
..     .. |
knikasnleie

0051429 (Phosphotyrosine protein) phosphatases II 1121-1336 1.7e-50 167.4 In-house 1-226 (272) alignment
Range on Protein: 1121-1336
Range on HMM: 1-226/272.0
IEGGDYINANYVPGFSS---RREFIAAQGPLPTTRDHFWQMtWEQQCPAIIALTKCVEKGRDKCHQYWP----------DHENVPVLYGDIEVTIVAEKE
.. ..||||..|.|. .   .. .....|||| | ..||.. .|... .|. |....|.||.||..|||          |..  ..|||.. ||.. |. 
lplsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

FDEFVIRDIRLEKSGPDGRVtRFVRHWHYMAWPDFGAPSHPngIIQFSRMFRHhlphsphNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPID-----
.. ...| ..|..  . | . | |.|.||..|||.|.|...  .... .....       . | .||||||..|.||.. ...||.  |  . .|     
lldyilrellltlllsagea.revmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYllt

---VFGTVCEMRYERCQMVQNEQQYIFIHYCILQVLQ
   ....| |.|  | ..||.|.||.|.. ..|..| 
nlyleeaveelraqrpgavqteeqylflyeallellr

0043147 (Phosphotyrosine protein) phosphatases II 1122-1329 5.9e-40 132.1 In-house 3-155 (172) alignment
Range on Protein: 1122-1329
Range on HMM: 3-155/172.0
EGGDYINANYVPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCvekgrdkchqywpdhenvpvlygdievtivaekefdefvirdirlekS
|| |||||.|...    ..||| ||||. | ..||.| .|... .|. ||..                                                
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...............................................l

GPDGRVTRFVRHWHYMAWPDFGAPsHPNGIIQFSRMFRHHLpHSPHNAPTIVHCSAGVGRSGTFISIDRLLqsssfgDPIDVFGTVCEMRYERCQMVQNE
 .   ..|.. ...|. |||.|.| ... ...| .  ...| .   . |..|||||||||.||.. .. .|        .... .|...|  |...|||.
ydpellerlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnp

QQYIFIHY
.||.|..|
sqyrflyy

0036282 (Phosphotyrosine protein) phosphatases II 1123-1329 1.5e-46 153.6 In-house 1-164 (174) alignment
Range on Protein: 1123-1329
Range on HMM: 1-164/174.0
GGDYINANYVPGFSSRREFIAAQGPLPttrdhFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDhenvpvlygdievtivaekefdefvirdirleksg
| |||||... ..   ...|| ||||.     ||.| .|... ... |....|.|. ||..|||.                                   
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................

PDGRVTRFVRHWHYMAWPDFGAPSHPNgIIQFSRMFRHHLPHsPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSfGDPIDVFGTVCEMRYERCQMVQNEQ
     .|.. ...|. |||.|.|. .  ...| .  ...| . ... |..|||||||||.||.. ....|.     ...|.. .| |.|. |..|||...
lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtps

QYIFIHY
||.|..|
Qyrflyy

0051082 (Phosphotyrosine protein) phosphatases II 1124-1332 1e-33 111.4 In-house 3-150 (151) alignment
Range on Protein: 1124-1332
Range on HMM: 3-150/151.0
GDYINANYVPGFssrreFIAAQGPLPttrdHFWQMTWEQQCPAIIALTKCVEKGrdKCHQYWPDHEnvpvlygdievtivaekefdefvirdirleksgp
 ||||..|| |.     ... .|||.    .|... .|... .|. |.. .| |  .|..|.|...                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

dgrvtRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHhlphsPHNAPTIVHCSAGVGRSGTFISIDRLLQSssfgdpIDVFGTVCEMRYERCQMVQNEQQ
     . |.|.... |||.| | ... ...| .....     . | |..||||||.||.||.. ....|.       .... .. |.|  |. .|| .||
.....ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqq

YIFIHYCIL
..|.....|
flfqlfall

0046846 (Phosphotyrosine protein) phosphatases II 1125-1335 6.6e-41 135.3 In-house 13-173 (176) alignment
Range on Protein: 1125-1335
Range on HMM: 13-173/176.0
DYINANYVPGFssrrEFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENVPVlygdievtivaekefdefvirdirleksgpd
||||||.. |      .|| ||||| |  .|..| .|... |.. ||..||.|| ||..|||. |.. .                               
dyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...............................

grvtrfvrHWHYMAWPDFGAPSHpNGIIQFSRMFRHHLPHSphnAPTIVHCSAGVGRSGTFISIDRLLQsssfGDPIDVFGTVCEMRYERC-QMVQNEQQ
        ..... |||.|.|.. . .... .. | .| .     |..||||||.||.||.. .. |      .  ..|. .....|  |. ..||...|
........qylhlpwpDhgvpdl.elllellefirealkeg...gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpeQ

YIFIHYCILQVL
| |.....|..|
yrflyefellll

0049260 (Phosphotyrosine protein) phosphatases II 1132-1329 4.4e-38 125.7 In-house 2-144 (152) alignment
Range on Protein: 1132-1329
Range on HMM: 2-144/152.0
VPGFSSRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWpdhenvpvlygdievtivaekefdefvirdirleksgpdgrvtrfv
..|.   .||||.|||.| | ..||.| .|... .|. ||...|.|..||.||.                                              
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..............................................

rHWHYMAWPDFGAPSHPNGIIQFSRMFRHHlpHSPHNAPTIVHCSAGVGRSGTFISIDRLLqsssfgDPIDVFGTVCEMRYERCQMVQNEQQYIFIHY
 ..... |||.|.|...  .... .. ...      . |..|||||||||.||.. .. .|        .... .|  .|  | ..|.|..|..|...
.qylhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1137-1328 6.4e-19 62.9 In-house 3-197 (199) alignment
Range on Protein: 1137-1328
Range on HMM: 3-197/199.0
SRREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDGRVTRFVRHWHY
..| .||.| ||  |   |||| ||     |. .     .       |||  |.    || . ||  .     ...|  . | ..      || . |. .
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

MAWPDFGAPSHP--NGIIQFSRMFRHHLpHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSS--SFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIH
 .| .  .|      |..  ||   ..     ..|| ||||| | | .| |...|  ..|   |    .|.|     .|  || ..   |.| ||.
tswkekttpnvalfvgfvvasrevskky.eqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1138-1328 6.7e-19 62.8 In-house 3-196 (198) alignment
Range on Protein: 1138-1328
Range on HMM: 3-196/198.0
RREFIAAQGPLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENVPVLYGDIEVTIVAEKEFDEFVIRDIRLEKSGPDGRVTRFVRHWHYM
.| .||.| ||  |   |||| ||     |. .     .       |||  |.    || . ||  .     ...|  . | ..      || . |. . 
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

AWPDFGAPSHP--NGIIQFSRMFRHHLpHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSS--SFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIH
.| .  .|      |..  ||   ..     ..|| ||||| | | .| |...|  ..|   |    .|.|     .|  || ..   |.| ||.
swkekttpnvalfvgfvvasrevskky.eqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1147-1335 1.4e-18 61.4 In-house 99-288 (302) alignment
Range on Protein: 1147-1335
Range on HMM: 99-288/302.0
PLPTTRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENVPVLYGDIEVTIV-AEKEFDEF------VIRDIRLEKSGPDGRVTRFVRHWHYMAW
|   |.. .| .  . .   .. |.. ||..  || .|. |. .  . .|   |. |  .....||      ..  . .. .    .| . |   .. ||
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDFGAPSHPNGIIQFSRMFRHhlphspHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVL
|| ||| ...  ..  .          .    .|||||||||.||...|   .|  |  .  |.   |. .|  |   ||.||| |..  |. . |
pdhGapkeaytaldilkfces......ykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkgl

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1151-1335 6.2e-17 56.5 In-house 40-221 (255) alignment
Range on Protein: 1151-1335
Range on HMM: 40-221/255.0
TRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENVPVLYGDIEVTIVAekEFDEFVIRDIRLEKSGPDGRVTRFVRHWHYMAWPDFGAPSHPNG
| |.|.|.   ..   .. |.   |.|..||..|.|   .    . |..||        . |.| ...     . . |. |.|..|  |..  ||  .. 
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

IIQFSRMFRHhlphSphnAPTIVHCSAGVGRSGTFISIDRLLQ------SSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVL
| .  .. |.    |    . .||||.|.||| .|. .. . |        .    .|    . |.| .| . ...  |  |  . .|...
ilnilkvvrd....s...ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv

subfamily_hpo-7_pd Subfamily hpo-7 1151-1335 1.3e-12 42.2 In-house 46-227 (263) alignment
Range on Protein: 1151-1335
Range on HMM: 46-227/263.0
TRDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENVPVLYGDIEVTIVAEKEfdEFVIRDIRLEKSGPDGRVTRFVRHWHYMAWPDFGAPSHPNG
| | |.|.   ..   .. |.   |.|..|| .|.|   .    . ...|.    ..  . ... . | .   . . |. |.|. |  |..  .|  .. 
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelare

IIQFSRMFRHhlphSphnAPTIVHCSAGVGRSGTFISIDRLLQ------SSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVL
|..  .. |.    |    . .||||.|.|||  |  .. . |        .    .|    . |.| .| . ...  |  |  . .|...
ilnilkvarn....s...kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfv

0048179 (Phosphotyrosine protein) phosphatases II 1222-1329 1.4e-23 78.7 In-house 40-139 (144) alignment
Range on Protein: 1222-1329
Range on HMM: 40-139/144.0
GPDGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPhspHNAPTIVHCSAGVGRSGTFISIDRLLqssSFGdpIDVFGTVCEMRYERCQMVQNE
 .   ..|.. ..... |||.|.|.... ...| ......|.   .. |..|||||||||.||.. .....    .|  .... .. ..|  |...|.|.
yepefleregiqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaaylmk...klg..lsleealalvrsrrpgavpnp

QQYIFIHY
.|..|...
gqlrfLle

0048076 (Phosphotyrosine protein) phosphatases II 1226-1334 4.9e-24 80.1 In-house 42-142 (145) alignment
Range on Protein: 1226-1334
Range on HMM: 42-142/145.0
RVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPHsphNAPTIVHCSAGVGRSGTFISIDRLLQsssfgDPIDVFGTVCEMRYERCQMVQNEQQYI
 ..|.. ...|. |||.|.|. .. ...| .. ...|..   . |..|||||||||.||.. .. .|.       .... .. ..|  | ..|.|..|..
llerlgiqylylpwpDhgvpdllellleflefieealke...ggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlr

FIHYCILQV
|.....|..
flyefelel

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1227-1335 3.9e-19 63.3 In-house 87-194 (440) alignment
Range on Protein: 1227-1335
Range on HMM: 87-194/440.0
VTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLpHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIF
 .| ....|| .||| | |     .... .   .   .   |.| .||||||.||.|  |..| .|. .   | ||.|  .  || .| ||||  .|| |
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesq.ekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

IHYCILQVL
.| ..|. |
vheavlegl

0038934 (Phosphotyrosine protein) phosphatases II 1228-1287 1.9e-07 26.4 In-house 76-134 (194) alignment
Range on Protein: 1228-1287
Range on HMM: 76-134/194.0
TRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPHSPHNaPTIVHCSAGVGRSGTFIS
..   ... . .||.|..   . . .| ..  ..|  .|..    ||| ||.||.||.. 
ekagieylklpfpddgtvPsleillrfldlvdeflnedpgg.vvaVHCkaGlgRtGtlva

PTPc_DSPc_SM00012 1231-1332 4e-33 109.1 In-house 2-104 (105) alignment
Range on Protein: 1231-1332
Range on HMM: 2-104/105.0
VRHWHYMAWPDFGAPSHPNGIIQFSRMFRHHLPHSPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFG-DPIDVFGTVCEMRYERCQMVQNEQQYIFIHY
|.| ||..|||.|.|.... |... | ....  .| ...|..|||||||||.|||. .| |||. . . . .|.| .|.|.| .| .|||.|.||.|.. 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

CIL
..|
all

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1231-1333 5.4e-14 46.7 In-house 217-342 (350) alignment
Range on Protein: 1231-1333
Range on HMM: 217-342/350.0
VRHWHYMAWPDFGAPSHPNGIIQFSR--------MFRHHLPHSPHNAPTIVHCSAGVGRSGTFISIDRLLQS-----------------SSFGDPIdvFG
| . ..  |.| .   .|. |.|           .| .   .. . .| .||||||||| ||....| ||.                  .   |.|  . 
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDli..si

TVCEMRYERCQMVQNEQQYIFIHYCILQ
.| |.|  | .|||| .|.|||. ..| 
ivnelrkqrismvqnldqfifiYeallf

PTEN_1 1234-1286 5.7e-06 21.3 In-house 97-148 (196) alignment
Range on Protein: 1234-1286
Range on HMM: 97-148/196.0
WHYMAWPDFGAPShPNGIIQFSRMFRHHLPHSPHNAPTIVHCSAGVGRSGTFI
.. . ..|.||||  . .. . . | . |   |..   .||| ||.||||| .
ylhfpieDhgaps.lselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1265-1334 2.7e-10 34.6 In-house 225-294 (297) alignment
Range on Protein: 1265-1334
Range on HMM: 225-294/297.0
SPHNAPTIVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQV
 | ||...|||||||||||  .  | .|.    .   ||   .  .| .| ..||  .|. ...  .|. 
mprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkk

subfamily_CG42327_pd Subfamily CG42327 1267-1329 3e-11 37.6 In-house 246-309 (319) alignment
Range on Protein: 1267-1329
Range on HMM: 246-309/319.0
HNAPTIVHCSAGVGRSGTFISIDRLLQSSSFG-DPIDVFGTVCEMRYERCQMVQNEQQYIFIHY
.. | .|||| ||||.|. |. |  ..|       .|.  .|  .| .|.. |.. .|| ||. 
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiyk

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1267-1333 2.1e-08 27.9 In-house 264-342 (349) alignment
Range on Protein: 1267-1333
Range on HMM: 264-342/349.0
HNAPTIVHCSAGVGRSGTFISIDRLLQ--------------SSSFGDPIdvFGTVCEMRYERCQMVQNEQQYIFIHYCILQ
. .. .|||||| ||.|... .| ||.               .   |.|  . .| |.|  | .|||| .|.|.|. ..|.
qlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDli..siivnelrkqrismvqnlaqfiaiyealLk

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1272-1335 8.9e-13 42.4 In-house 2-65 (69) alignment
Range on Protein: 1272-1335
Range on HMM: 2-65/69.0
IVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVL
.||||.| ||.||||.|   .        .|.|  |  ||  |  || ||..|||||  . . |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1272-1335 3.6e-12 40.4 In-house 1-64 (69) alignment
Range on Protein: 1272-1335
Range on HMM: 1-64/69.0
IVHCSAGVGRSGTFISIDRLLQSSSFGDPIDVFGTVCEMRYERCQMVQNEQQYIFIHYCILQVL
.||||.| ||.||||.|   .        .|.|  |  ||  |  || || .|.|||  . . |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal