Gene Y54F10BM.13 in Caenorhabditis elegans

Synonym: CELE_Y54F10BM.13, Y54F10BM.13

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP19
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP221_AA protein Get Run
CeleP221_AA_80-222 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP19_pd Subfamily DSP19 72-220 4.9e-66 215.8 In-house 1-150 (152) alignment 
Range on Protein: 72-220
Range on HMM: 1-150/152.0
GFIVDLEPDLVVGEALPDLLFGSQDVAADLPILENRKITHIVNVGTGIPNHFPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGI
||..||..|| |||. |.|..||||||||  ||...|||||.||.||.||.|||.|.||.|.|||||||....|......||...|...|.|..|||||.
gfveDlkedlevgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGv

SRSATFVVAYLMKNLKISCREAMDKCRETR-SIRPNTGFAQQLKEYEAIL
||||..|.|||||. ..|..||....||.| .|.||.||..||||||| |
SRsasvviaylmkkeelsleealelvrearpcikPneGFikqLkeyeael
0041856 (Phosphotyrosine protein) phosphatases II 74-221 1.5e-32 108.0 In-house 10-173 (182) alignment 
Range on Protein: 74-221
Range on HMM: 10-173/182.0
IVDLEPDLVVGEALPDLLFGSQDV--------------AADLPILENRKITHIVNVGtgIPNHFPKKF-----EYLQIDILDLPETRiidyFERVFEFID
|.  .....  . .. |. ||.                |..|. | ...||.|||.    ....|...     .||.. . | . .     .. ...||.
ilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd....ldelldfie

KVRQNEGIVFIHCNAGISRSATFVVAYLMKNLKISCREAMDKCRETRS---IRPNTGFAQQLKEYEAILV
.|....| |..||.||..|..|.|.||||| |..| .||..  |. |.   |.|| .|  ||...| .|.
evleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellll
0044763 (Phosphotyrosine protein) phosphatases II 75-222 1.3e-38 127.8 In-house 19-172 (178) alignment 
Range on Protein: 75-222
Range on HMM: 19-172/178.0
VDLEPDLVVgealPDLLFGSQDVAADLPILENRKITHIVNVGTGIPNHFPKK---------FEYLQIDILDLPETRIIDYFERVFEFIDKVR-QNEGIVF
  . .. ..    |.|. ||.  |.||. | . .||||||. . ....|.|          ..||.| | | ... ....|....|||.... ...| |.
dyinaseil....pglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvl

IHCNAGISRSATFVVAYLMKNLKISCREAMDKCRETRSIRPNTGFAQQLKEYEAILVS
.||.||..||.|.|.||||| |..|  ||..  || |.| || |. .||.|.| .| .
VHCsaGvgRsgtlvaaylmkklglsleeaielvrerRpivpnpgqlrqLyefelrllk
0045098 (Phosphotyrosine protein) phosphatases II 77-222 1e-30 102.5 In-house 16-273 (278) alignment 
Range on Protein: 77-222
Range on HMM: 16-273/278.0
LEPDLVVGEALPDLLFGSQD-----------------------------------------VAADLPILENRKITHIVNVG-------------------
| .   ..| .| |. |..|                                         ||...  | . .||.||..                    
llllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggs

---------------------------------TGIPNHFPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQ--------------NEGIVFIHCNA
                                 ....... . . || ..  . |.. |...| ...|||.....              ..| |..||.|
ltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsa

GISRSATFVVAYLMKNL---KISCREAMDKCRETRS--IRPNTGFAQQLKEYEAILVS
|..|..|.|.||||. |   ...  || .. |. |   . .| .. ..| |... |..
GvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_LRR-DSP_pd Subfamily LRR-DSP 81-221 6.8e-38 124.2 In-house 118-259 (263) alignment 
Range on Protein: 81-221
Range on HMM: 118-259/263.0
LVVGEALPDLLFGSQDVAADLPILENRKITHI-VNVGTGIPnHFPKKFEYLQI-DILDLPETRIIDYFERVFEFIDKVRQNEGiVFIHCNAGISRSATFV
 |  | ...| .|..| | . .||..  .||| . |.   |  ||| | || | || | .|  |  .||..  ||.. |.. | |..|| ||.|||.| |
svPdeiidklflGgldsannksilkdlgvthillavadfeP.lfPklfkylsiddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGvsrsstlv

VAYLMKNLKISCREAMDKCRETRS-IRPNTGFAQQLKEYEAILV
..||||. ..  .||.|   . |. |.||.|| .||| ||. |.
isylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklf
0049772 (Phosphotyrosine protein) phosphatases II 82-220 2.7e-31 104.9 In-house 155-273 (314) alignment 
Range on Protein: 82-220
Range on HMM: 155-273/314.0
VvgealpdllfgSQDVAADLPILEnrkithivnvgTGI--PNHFPKK-FEYLQIDILDlPETRIIDYFERVFEFIDKVrQNEGIVFIHCNAGISRSATF-
            .. .||||. |.           . .  |..|..  ..||.|.. | ... ....|....|||... ...| |..||.||..|..|| 
g...........neptaadlellk...........eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfv

VVAYLMKNLKISCREAMDKCRETRSIRPNTGFAQQLKEYEAIL
|.||||| |..| .||..  |..|.|.|| || .||..|| ||
vaaylmkllgvsleealedvrlkRpinpnpgfieqleqyefil
subfamily_DSP3_pd Subfamily DSP3 83-220 3.7e-33 108.5 In-house 11-157 (162) alignment 
Range on Protein: 83-220
Range on HMM: 11-157/162.0
VGEALPDLLFGSQDVAADLPILENRKITHIVNVGTGI-------PNHFP-KKFEYLQIDILDLPETRIIDYFERVFEFIDK-VRQNEGIVFIHCNAGISR
| |  |.|  | ..|| |   |..  |||..|   |        ....   ...|| ... | ||. .  |||....|||. . |.|| |..||..|.||
vdevypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsR

SATFVVAYLMKNLKISCREAMDKCRETRSIRPNTGFAQQLKEYEAIL
||| |.||||   |..  ||. . |. |.|.||.|| .||.|..  |
satlvlayLmirrkmtlveairtvrkkReilPneGFlkqLaeldeel
0046846 (Phosphotyrosine protein) phosphatases II 84-220 4.8e-27 90.2 In-house 13-172 (176) alignment 
Range on Protein: 84-220
Range on HMM: 13-172/176.0
GEALPDLLFGSQD----------VAADLPILENRKITHIVNVGTGI-------PN----HFPKKFEYLQIDILDLPETRIiDYFERVFEFIDKVRQNEGI
 . ...|..||            .|..|  | . .||..||. . .       ||        ...||.... |     . .......|||...... | 
dyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeggp

VFIHCNAGISRSATFVVAYLMKN-LKISCREAMDKCRETR--SIRPNTGFAQQLKEYEAIL
| .|| |||.|..|.|.|||..    .|  ||... || |   . .. .. ..|.|.|  |
vlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll
subfamily_DSP12_pd Subfamily DSP12 85-222 6.5e-39 127.8 In-house 4-145 (155) alignment 
Range on Protein: 85-222
Range on HMM: 4-145/155.0
EALPDLLFGSQDVAADLPILENRKITHIVNVGTG-IPNHFPKK--FEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAY
. || |..|.   ... . |.. ||||.. | .  .|.| .||   ....|.||| ||. |.........||.. ...|| |..||.||.|||.|.|.||
rilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAY

LMKNLKISCREAMDKCRETR-SIRPNTGFAQQLKEYEAILVS
|||. |.|. .|... .| . .|.||.|| .||| .|.. ..
lmkkeklslekAlklvkekkpeiepNegFleQLklfekmgck
subfamily_DSP10_pd Subfamily DSP10 85-220 3.1e-38 125.2 In-house 16-153 (159) alignment 
Range on Protein: 85-220
Range on HMM: 16-153/159.0
EALPDLLFGSQDVAADLPILENRKITHIVNVGTGIPNHFPK-KFEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLM
. || |..||.  |||| .|.. .||...|| | .||.| . ...| .|.. |  .  .  |||  .|||...|...  |..||.||||||||.|.||||
qvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaYlm

KNLKISCREAMDKCRETRS-IRPNTGFAQQLKEYEAIL
|.|..| ..| .  .|.|. | || .|  ||.|.|  |
khlnlslndaykfvkekrpiisPnLnfmGqLlefekel
subfamily_DSP15_pd Subfamily DSP15 85-218 1e-34 113.8 In-house 4-137 (151) alignment 
Range on Protein: 85-218
Range on HMM: 4-137/151.0
EALPDLLFGSQDVAADLPILENRKITHIVNVGTgIPNHFPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLMK
. ||.|  |   .. |   |....||||..|    .... |..||. | . | |.. .  .|.   ||| | | .|. |..|| ||.|||.| |||||| 
kvlpglylgnfrdskdeelLkeknithilsvhd.nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmt

NLKISCREAMDKCRETRSI-RPNTGFAQQLKEYEA
 .... |.|..  ...||.  ||.|| .|||||| 
vtelnwrdalevikaaRsvanPnfGfkrqlkeyek
0048076 (Phosphotyrosine protein) phosphatases II 85-220 2e-34 113.7 In-house 6-142 (145) alignment 
Range on Protein: 85-220
Range on HMM: 6-142/145.0
EALPDLLFGSQDVAADLPILENRKITHIVNVGTGIPNHFPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLMK
| ||.| .||. .| ||. |.. .||...|. . ....... ..||.... | ..  .........|||.......| |..||.||..|..|.|.||||.
eilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylml

NLKISCREAMDKCRETRS-IRPNTGFAQQLKEYEAIL
 |..|  ||... |. |. . || |. ..|.|.| .|
llgvsleealelvrsqrpgavpnpgqlrflyefelel
subfamily_DSP6_pd Subfamily DSP6 85-220 3.6e-34 111.6 In-house 16-154 (158) alignment 
Range on Protein: 85-220
Range on HMM: 16-154/158.0
EALPDLLFGSQDVAADLPILENRKITHIVNVGTGIPNHFPK--KFEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYL
| || | .||.. |..| .|.. || ...|| . .|| | .  ...|||| | |  .. .  .|   .||||. |...  |..|| |||||| | ..|||
eilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlayl

MKNLKISCREAMDKCRETRS-IRPNTGFAQQLKEYEAIL
||.|..|  .| |  .. .| | ||  | .||...|  |
mkklalslndaydlvkkrksnisPnfnfmgqlldfersl
0048179 (Phosphotyrosine protein) phosphatases II 85-220 3.4e-33 109.7 In-house 6-144 (144) alignment 
Range on Protein: 85-220
Range on HMM: 6-144/144.0
EALPDLLFGSQDVAADLPILENRKITHIVNVGTGIPNHFPKKF--EYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYL
| ||.| .||. .| ||. | . .||...|. .. ...|....  .||.... | .   .........|||.......| |..||.||..|..|.|.|||
eilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaayl

MKNLKISCREAMDKCRETRS-IRPNTGFAQQLKEYEAIL
|| |..|  ||..  |. |. . || |. ..|.||| .|
mkklglsleealalvrsrrpgavpnpgqlrfLleyekll
subfamily_STYX_pd Subfamily STYX 85-221 1e-30 100.0 In-house 14-158 (166) alignment 
Range on Protein: 85-221
Range on HMM: 14-158/166.0
EALPDLLFGSQDVA--ADLPILENRKITHIVNVGTG-----IPNHFPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATF
| || | .|    |  . |..|... ||||| .        |   ||..| || .|. | .   || |. .| ||||.  |. | |..| ||||||||..
eilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaal

VVAYLMKNLKISCREAMDKCRETR-SIRPNTGFAQQLKEYEAILV
|.||.|.   .  |||.   .| |  | || ||..|||||||| .
viayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiyl
subfamily_DSP8_pd Subfamily DSP8 85-220 3.7e-30 98.6 In-house 17-154 (159) alignment 
Range on Protein: 85-220
Range on HMM: 17-154/159.0
EALPDLLFGSQDVAADLPILENRKITHIVNVGTGIP-NHFPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLM
. |. | .||| .. .  .|..  |....|. .  |  .. |. ..|.. . |  . .....|.. .|||||.....| |..|. |||||||| ..||.|
rilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaiayim

KNLKISCREAMDKCRETR-SIRPNTGFAQQLKEYEAIL
|.|..|  ||    .| | .| ||  | .|| |||  |
ktlemsldeayrfvkekrptispnlnflgqLleyekel
0037934 (Phosphotyrosine protein) phosphatases II 85-219 5.1e-26 87.1 In-house 43-240 (243) alignment 
Range on Protein: 85-219
Range on HMM: 43-240/243.0
EalPDLLFGSQ--------DVAADLPILENRKITHIVNVGTGI---------------------------------------------PNHFPKKFEYLQ
   | |  ...        |.|...  | . .||.||.. . .                                             ....   . |..
t..prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhy

IDILD----LPETRIIDYFERVFEFIDK-----VRQNEGIVFIHCNAGISRSATFVVAYLMKNL-KISCREAMDKCRETRS--IRPNTGFAQQLKEYEAI
. . |       . ..|... | |||..     .. ..| | .|| ||..|..|...||||. | ...  ||... || |.  . .. .. ..| |... 
lpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_STYXL1_pd Subfamily STYXL1 85-220 1.2e-22 73.9 In-house 13-153 (157) alignment 
Range on Protein: 85-220
Range on HMM: 13-153/157.0
EALPDLLF-GSQDVAADLPILENRKITHIVNVGTG---IPNHFPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVA
| ||. |. |    | .  | .. |.   ||| .    . .  ..  . |.|.. | .|. ... .... .||.| .... .|..  | ||||||. ..|
evlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviia

YLMKNLKISCREAMDKCRETRS-IRPNTGFAQQLKEYEAIL
||| . ||. ..|... .. .. ..|| .| .||.|.|  |
ylmyskkitlkkaykylkkCkenvkPnrafveqlseWekql
0051429 (Phosphotyrosine protein) phosphatases II 85-218 7.1e-19 64.0 In-house 18-222 (272) alignment 
Range on Protein: 85-218
Range on HMM: 18-222/272.0
EALPDLLFGSQDV----AADLPILENRKITHIVNVGTGIPNHFPK------KFEYLQIDILDLPETRIIDYF----------------------------
. .|..|. |.      |||.. |.. .|..||.. .     . |       ..||...|||  ...|  ..                            
vvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsag

--------------------ERVFEFIDKVRQnEGIVFIHCNAGISRSATFVVAYLMKnLKIS--------------CREAMDKCRETR-SIRPNTGFAQ
                    | . |... ... .| | .||.||..|..|.|...|.  | .|               .||... |. |  .... .. .
earevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqyl

QLKEYEA
.| |...
flyeall
subfamily_DSP1_pd Subfamily DSP1 86-219 9.3e-45 146.6 In-house 21-155 (163) alignment 
Range on Protein: 86-219
Range on HMM: 21-155/163.0
ALPDLLFGSQDVAADLPILENRKITHIVNVGTGIPNHFPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLMKN
 |. | .||. ||..| ||.. .||.|.|| . ..|.|.. ||| .. . | |.  |  .||.| ||||.|....| |.|||.||||||.|...|||||.
ildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclaylmkt

LKISCREAMDKCRETRSI-RPNTGFAQQLKEYEAI
 ..|  ||.| ... ||| .||.|| .||..||  
krvsleeafdfvkqrRsiisPnagFvlqLlnyekk
PTPc_motif_SM00404 86-218 8.3e-39 127.7 In-house 5-139 (140) alignment 
Range on Protein: 86-218
Range on HMM: 5-139/140.0
ALPDLLFGSQDVAADLPILENRKITHIVNVGTGIPN-HFPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLMK
 ||.| .||.. | ....|.. .|||..||.. ...    ..|..|||.. |  .. . .|...| .||.......| |..|| ||.|||||...||||.
ilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlmr

NLKISCREAMDKCRETRS-IRPNTGFAQQLKEYEA
  ..| .||..  .| |. |.||..| .|| ||| 
yrqlslaeayefvkerRpiispnlnfvrqLieyek
0043147 (Phosphotyrosine protein) phosphatases II 87-220 9e-30 99.0 In-house 23-160 (172) alignment 
Range on Protein: 87-220
Range on HMM: 23-160/172.0
LPDLLFGSQDVAADLPILENRKITHIVNVGTG---IPNHFPKKFEYLQIDILDLPETrIIDYFERVFEFIDK--VRQNEGIVFIHCNAGISRSATFVVAY
.. .  .. ..| ..  | ...||||||. .     .. ..  ..|| . . | . . .........||||.  .....| | .|| ||..|..|.|.||
iatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaay

LMKnLKISCREAMDKCRETRS-IRPNTGFAQQLKEYEAIL
||. |..|  ||..  || |. . .| .. ..|...| .|
lml.lglsleeavalvrekRpgavqnpsqyrflyyfekll
0051082 (Phosphotyrosine protein) phosphatases II 87-216 4.2e-26 86.8 In-house 12-149 (151) alignment 
Range on Protein: 87-216
Range on HMM: 12-149/151.0
LPDLLFGSQDVAADLPILENRKITHIVNVGTGI-----PNHFPK-KFEYLQIDILDLPETRIIDYFERVFEFIDKVRQN-EGIVFIHCNAGISRSATFVV
 . |. ...  |..|. |.. .|..|||. .       |. .|.  .|.|.| ||| |.. . ..|. | ||....... .| |..||.||..|..|.|.
tgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlva

AYLMKnLKISCREAMDKCRETR--SIRPNTGFAQQLKEY
.|||. |..|  ||..  |..|  ...||..|  ||...
lylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal
0049260 (Phosphotyrosine protein) phosphatases II 88-219 6.4e-27 89.5 In-house 13-148 (152) alignment 
Range on Protein: 88-219
Range on HMM: 13-148/152.0
PDLLFGSQDVAADLPILENRKITHIVNVGTGIPNH---FPKKFEYLQIDILDLPETRIIDYFERVFEFIDK-VRQNEGIVFIHCNAGISRSATFVVAYLM
. .  |....| ..  | . .||.||.. .  ...   ... ..||.. . | .   ...... ...||.|  ....| |..|| ||..|..|.|.||||
atqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylm

KnLKISCREAMDKCRETRS-IRPNTGFAQQLKEYEAI
. |..|  ||..  || |. . || |. ..|.|.| .
l.lgvsleeavalvrekRpgavpnpgqlrflyefekl
0036282 (Phosphotyrosine protein) phosphatases II 88-219 9.3e-25 82.7 In-house 17-168 (174) alignment 
Range on Protein: 88-219
Range on HMM: 17-168/174.0
PDLLFGSQDVAaDLPILENRKITHIVNVGTGIPNH---------------FPKKFEYLQIDILDLPETRIIDyFERVFEFIDKVRQN--EGIVFIHCNAG
| |. |.   | ... | . .||..|.. . ....                .  ..||.. . |  .  .   ......|.......  .| | .||.||
prliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaG

ISRSATFVVAYLMKNLKI-SCREAMDKCRETR----SIRPNTGFAQQLKEYEAI
..|..|.|.||||. ... | ..|.|  || |     . .. .. ..| ..| .
vgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekl
0042113 (Phosphotyrosine protein) phosphatases II 89-220 3.2e-23 77.8 In-house 53-242 (245) alignment 
Range on Protein: 89-220
Range on HMM: 53-242/245.0
DLLFGSQDVAADLP----ILENRKITHIVNVGTGIPNHFPK----------------------------------------------KFEYLQIDILDLP
 .. ...  . ...     | . .||.||.. .  .....|                                               . |..... | .
kfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhg

ETRIIDYFERVFEFIDKVRQ--NEGIVFIHCNAGISRSATFVVAYLM-----KNLKISCREAMDKCRETR-SIRPNTGFAQQLKEYEAIL
.. .........||..|...  ..| |..||.||..|..||..||||     |.|..|  ||... |. |  .... .. ..| |... |
vpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
subfamily_PTPMT1_pd Subfamily PTPMT1 89-220 3.8e-19 63.8 In-house 39-168 (171) alignment 
Range on Protein: 89-220
Range on HMM: 39-168/171.0
DLLFGSQDVAADLPILENRKITHIVNVGTGIPNHfpkKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLMKNLKI
. |. ...|.| ... |. ......|      ..     |.||. . |  |.  ..  |.  |||.||...   |..||.|| .|||| | .||||. |.
keLiekenvkavvslneeyelkalansteewkkl...gveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkekl

SCREAMDKCRETRS-IRPNTGFAQQLKEYEAIL
|  ||..  .. |. || ..   ..|.|||  |
speeAlkalkkkRkiirlakkqwkalqeyeekl
subfamily_Slingshot_pd Subfamily Slingshot 90-221 2.5e-38 125.1 In-house 26-158 (169) alignment 
Range on Protein: 90-221
Range on HMM: 26-158/169.0
LLFGSQDVAADLPILENRKITHIVNVGTGIPNHFPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLMKNLKIS
. .||.  |..|  |.......|.||   | |.||.|||||.| . | .|| ...|... ..||.|.....  |..||  |.||||. |.|| ||. ..|
vylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayamkeygls

CREAMDKCRETRS-IRPNTGFAQQLKEYEAILV
  ||..  .| || |.||.|| .||.||| || 
leealeyvkerrsvikPnkgflkqleeyeGile
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 90-217 1.1e-34 113.1 In-house 10-149 (154) alignment 
Range on Protein: 90-217
Range on HMM: 10-149/154.0
LLFGSQDVAADLPILENRKITHIVNVGTGIPNHFPKK---------FEYLQIDILDLPETRIIDYFERVFEFIDKVR--QNEGIVFIHCNAGISRSATFV
|  .|.| | .   |....|..|.|||.||.| |...         .|||.... | ..  ||. ....|||||.     ... |..|...|.||||...
lyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaall

VAYLMKNLKISCREAMDKCRETRS-IRPNTGFAQQLKEYE
..|||..||||  .|.   ...|  |.||.|| .||. .|
isylmdklkislslalellkdsryiikPnqGflkqleife
subfamily_MKPLT_pd Subfamily MKPLT 90-220 6.9e-32 104.2 In-house 29-160 (164) alignment 
Range on Protein: 90-220
Range on HMM: 29-160/164.0
LLFGSQDVAADLPILENRKITHIVNVGTGIPNHFPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLMKNLKIS
|  |  . | .  .|.. |||||||| ..  . ||| .||||... | .........||. .|. .  .. | |..||. | |||..  ||.|.|  .  
lylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwt

CREAMDKCRETRSI-RPNTGFAQQLKEYEAIL
 .|| .  .| ||| .|| || .|| ..| ..
lkeayeylkerrsivapnrGflkqlakfeeli
subfamily_MKPLV_pd Subfamily MKPLV 90-220 6.9e-32 104.2 In-house 29-160 (164) alignment 
Range on Protein: 90-220
Range on HMM: 29-160/164.0
LLFGSQDVAADLPILENRKITHIVNVGTGIPNHFPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLMKNLKIS
|  |  . | .  .|.. |||||||| ..  . ||| .||||... | .........||. .|. .  .. | |..||. | |||..  ||.|.|  .  
lylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwt

CREAMDKCRETRSI-RPNTGFAQQLKEYEAIL
 .|| .  .| ||| .|| || .|| ..| ..
lkeayeylkerrsivapnrGflkqlakfeeli
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 90-217 7.3e-25 81.2 In-house 15-144 (148) alignment 
Range on Protein: 90-217
Range on HMM: 15-144/148.0
LLFGSQDVAADLPILENRKITHIVNVGTGIPNHFPKK-FEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLMKNLKI
|  ||.  ||||  |..  .|.|||     .| . ..  |||.. . | |.  .  .|| . .|..|.... . | .|.. |.|||.  ....|..  ..
LFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkrv

SCREAMDKCRE-TRSIRPNTGFAQQLKEYE
| .||..  .. .| ..|| || .|| |.|
slkealalvkskrryvdpnlgfLkqLaele
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 90-216 1.9e-18 60.0 In-house 6-137 (145) alignment 
Range on Protein: 90-216
Range on HMM: 6-137/145.0
LLFGSQDVAADLPILENRKITHIVNVGTGI----PNHFPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLMKN
|. ||   | |.|.|..  |. |||. .|      .   ...| | |   ||    . ..|. | .|||| ...   ||.|| ||.||| |  ||.||| 
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

LKISCREAMDKCRETRS-IRPNTGFAQQLKEY
 ...  ||  . |  |    ||  | ..| . 
cnmtlseaarqvrsnrllaypnvtflknllnl
subfamily_DSP14_pd Subfamily DSP14 91-219 2.1e-36 119.3 In-house 14-143 (157) alignment 
Range on Protein: 91-219
Range on HMM: 14-143/157.0
LFGSQDVAADLPILENRKITHIVNVGTGIPNHFPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLMKNLKISC
|| |  .| .   |...|||.|.|| . .||.  |..|.... . | ||... ..|..| . |..|....| . .|| ||.||||....|||||  |.| 
LflsgvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylmkyeklsL

REAMDKCRETRS-IRPNTGFAQQLKEYEAI
|||    ...|. ||||.|| .|| .||  
reayklvksaRpiirPNvGFwkqlidyEkk
DSPc Dual specificity phosphatase, catalytic domain 92-218 9.9e-36 117.5 Pfam-A 3-132 (133) alignment 
Range on Protein: 92-218
Range on HMM: 3-132/133.0
FGSQDVAAdLPILENRKITHIVNVGTGIPN-HF--PKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLMKNLKI
.||.  |  |..||. .||...|| . .|| ..  ....|||.| . |  || | ...|.. |||.|..|... |..||.||||||||...|||||  ..
lgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknl

SCREAMDKCRETRS-IRPNTGFAQQLKEYEA
| .||..  .| || |.||.|| .|| ||| 
slneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 92-218 9.9e-36 117.5 In-house 3-132 (133) alignment 
Range on Protein: 92-218
Range on HMM: 3-132/133.0
FGSQDVAAdLPILENRKITHIVNVGTGIPN-HF--PKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLMKNLKI
.||.  |  |..||. .||...|| . .|| ..  ....|||.| . |  || | ...|.. |||.|..|... |..||.||||||||...|||||  ..
lgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknl

SCREAMDKCRETRS-IRPNTGFAQQLKEYEA
| .||..  .| || |.||.|| .|| ||| 
slneAyefvkerrskispnagflrqLleyer
0040439 (Phosphotyrosine protein) phosphatases II 94-220 3.7e-29 97.5 In-house 64-245 (249) alignment 
Range on Protein: 94-220
Range on HMM: 64-245/249.0
SQDVAADLPILENRKITHIVNVGTGIPN-------------------------------------------HFPKKFEYLQIDILDLPETRIIDYFERVF
.. |....  | . .||.||.. .  ..                                            .......|.| ..|.|.. . ..|| ..
petvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedll

EFIDKVRQ------NEGIVFIHCNAGISRSATFVVAYLM-----KNLKISCREAMDKCRETR-SIRPNTGFAQQLKEYEAIL
.||..||.      ..| |..||.||..|..||..||||     |.|...  ||... |. |  . .| .. ..| |... |
dfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
PTEN_1 95-221 1.4e-29 98.3 In-house 54-192 (196) alignment 
Range on Protein: 95-221
Range on HMM: 54-192/196.0
QDVAADLPILENRKITHIVNVGTGIPN---------HFPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQ--NEGIVFIHCNAGISRSATFVVAYLM
 ||||||  |. ..||..||.  . ..         .| ...|||...| | .   .   |. . .||. ...  |...| .|| ||..||.| | ||||
kdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLm

KNLKISCREAMDKCRETR-SIRPNTGFAQQLKEYEAILV
.  | . .||..  || |  ..||... ..|.||.| | 
ykgkltadeAlelvrekRppgapnspsqerlleyfaell
0045450 (Phosphotyrosine protein) phosphatases II 104-220 1e-24 83.3 In-house 127-303 (307) alignment 
Range on Protein: 104-220
Range on HMM: 127-303/307.0
LENRKITHIVNVGTGIPNHF----------------------------PKKFEYLQIDILDL-----------------PETRIIDYFERVFEFIDKVRQ
| . ..|.||.. . ... .                             ... .... . ||                 |.. . ..|| ...||..||.
lweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrk

------NEGIVFIHCNAGISRSATFVVAYLMKNLK--------ISCREAMDKCRETR-SIRPNTGFAQQLKEYEAIL
      ..| | .||.||..|..||..||||. .         .. .||... || |  . .| .. ..| |... |
aleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
0040438 (Phosphotyrosine protein) phosphatases II 104-221 2.4e-23 78.3 In-house 106-276 (317) alignment 
Range on Protein: 104-221
Range on HMM: 106-276/317.0
LENRKITHIVNVGTGIPNH---------------------------FPKKFEYLQIDILDL----------------PETRIIDYFERVFEFIDKVRQN-
. . ..|.||.. .  ..                              . ...... . ||                |.  . .... ...|...||.. 
vweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal

---EGIVFIHCNAGISRSATFVVAYLM-----KNLKISCREAMDKCRETRS-IRPNTGFAQQLKEYEAILV
   .| | .||.||..|..||..||||     |. ...  ||... || |. . .. .. ..| .... ..
edpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
0039614 (Phosphotyrosine protein) phosphatases II 104-222 3.5e-21 71.4 In-house 121-290 (297) alignment 
Range on Protein: 104-222
Range on HMM: 121-290/297.0
LENRKITHIVNVGTGIPNHFpKKFEYL-------------------------------------------QIDILDLPETRIIDYFERVFEFIDKVRQ--
. . ..|.||.. . ...   | ..|                                             ... |     ..... ...|.......  
vweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealael

-NEGIVFIHCNAGISRSATFVVAYLM-----KNLKISCREAMDKCRETR-SIRPNTGFAQQLKEYEAILVS
 ..| | .||.||..|..||..||||     |. ...  ||... || |  .... .. ..| .... |..
pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk
0043336 (Phosphotyrosine protein) phosphatases II 104-218 1.6e-18 62.6 In-house 108-274 (278) alignment 
Range on Protein: 104-218
Range on HMM: 108-274/278.0
LENRKITHIVNVGTGIPN------------------------------------------HFPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQ---
. . ..|.||.. .   .                                            ..... ...  |. |.  . . .. ...|. .||.   
vwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale

-NEGIVFIHCNAGISRSATFVVAYLM-----KNLKISCREAMDKCRETR-SIRPNTGFAQQLKEYEA
 ..| | .||.||..|..||...||.     |.....  ||... || | .. ..  . ..| |...
dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall
0038934 (Phosphotyrosine protein) phosphatases II 105-216 1.8e-18 62.3 In-house 53-172 (194) alignment 
Range on Protein: 105-216
Range on HMM: 53-172/194.0
ENRKITHIVNVGTGIPNHFPKKFEYLQIDILDLPETRI--IDYFERVFEFIDKV-----RQNEGIVFIHCNAGISRSATFVVAYLMKNLKISCREAMDKC
 |.|.......    .   |..|| . |..|.||      .  .| ...|.| |     ....|.| .|| ||..|..|.|.|||.. |..| .||..  
lnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialf

RETR-SIRPNTGFAQQLKEY
|| | .. || .. ..| ..
rekRpgaipnqdyleallkr
0051299 (Phosphotyrosine protein) phosphatases II 105-202 7.7e-17 57.1 In-house 160-266 (288) alignment 
Range on Protein: 105-202
Range on HMM: 160-266/288.0
ENRKITHIVNVGTGIPNHFPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQN----EGIVFIHCNAGISRSATFVVAYLM-----KNLKISCREAMD
.. .....  . .....   ..... ..  .. |.  . |..| ...|. .||.     .| | .||.||..|..||....|.     |. ...  ||. 
ddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavk

KCRETRS
. || | 
rlreqRp
0036941 (Phosphotyrosine protein) phosphatases II 106-221 6e-23 77.0 In-house 100-277 (297) alignment 
Range on Protein: 106-221
Range on HMM: 100-277/297.0
NRKITHIVNVGTGIPNHFPKKFEYLQ-----------------------------------------------IDILDLPETRIIDYFERVFEFIDKVRQ
. ..|.||.. . ... ..| ..|                                                 . ... |.  . .... ...||..||.
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk

------NEGIVFIHCNAGISRSATFVVAYLM--------KNLKISCREAMDKCRETR-SIRPNTGFAQQLKEYEAILV
      ..| | .||.||..||.||..|.||        |. ...  ||. | || |  . .. .. ..| |... |.
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
0047943 (Phosphotyrosine protein) phosphatases II 107-202 4.5e-17 57.8 In-house 100-252 (273) alignment 
Range on Protein: 107-202
Range on HMM: 100-252/273.0
RKITHIVNVGTGIPN----------------------------------------------HFPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQ--
 ....|| . . . .                                              ........ ..  .. |.  . ...| ..|||..||.  
qnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkal

----NEGIVFIHCNAGISRSATFVVAYLM-----KNLKISCREAMDKCRETRS
    ..| | .||.||..|..||....|.     |. ...  ||. . |. | 
ealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRp
0050432 (Phosphotyrosine protein) phosphatases II 119-203 1.2e-15 53.1 In-house 143-280 (308) alignment 
Range on Protein: 119-203
Range on HMM: 143-280/308.0
IPN----------------------------------------------HFPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQN--EGIVFIHCNAG
. |                                                .. ... ..  .. |.  . ...| ...|...||.   .| . .||.||
vengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaG

ISRSATFVVAYLM-----KNLKISCREAMDKCRETRSI
..|..||....|.     |. ...  ||. | || |  
vGRtGtfialdllleqlekeggvdvfeavkklReqRpg
subfamily_VSP_pd Subfamily VSP 120-193 2.7e-07 24.7 In-house 89-162 (212) alignment 
Range on Protein: 120-193
Range on HMM: 89-162/212.0
PNHFPKKFEYLQIDILDLPETR-IIDYFERVFEFIDKVRQNegIVFIHCNAGISRSATFVVAYLMKNLKIS-CREA
...| .. . ..||  ..|. . .. . ..| |...|  .|  ...|||  |  |. | | |.|..   ..  .|.
ekyfnnrvkriliddhnvpkleellvftkevkewlekdlkn..vlaihckGGkgrtGtivcalllaseifetakes
0046845 (Phosphotyrosine protein) phosphatases II 123-207 2.2e-14 49.0 In-house 161-254 (284) alignment 
Range on Protein: 123-207
Range on HMM: 161-254/284.0
FPKKFEYLQIDILDLPETRIIDYFERVFEFIDKVRQN------EGIVFIHCNAGISRSATFVVAYLMKNL--------KISCREAMDKCRETRsirpnT
  . ..  .. ... |.  . ...| ..||...||.       .| . .|| ||..|..||....|....        ...  ||. . || |      
tgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqR.....p
PTPc_DSPc_SM00012 126-206 1.1e-10 36.9 In-house 4-88 (105) alignment 
Range on Protein: 126-206
Range on HMM: 4-88/105.0
KFEYLQIDILDLPETRiidyfERVFEFIDKVRQNE------GIVFIHCNAGISRSATFVVAYLMKNLKISCR---EAMDKCRETRSIRPN
...|...    .||.      . ..|....|..|.      . | .|| ||..|..|||..... .   . .   .  . ..| |. ||.
hyhytgwpdhgvPees.....dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpg
DSPc_SM00195 127-202 2.2e-07 25.8 In-house 158-242 (263) alignment 
Range on Protein: 127-202
Range on HMM: 158-242/263.0
FEYLQIDILDLPETRIIDYFERVFEFIDKVRQN----EGIVFIHCNAGISRSATFVVAYLM-KNL----KISCREAMDKCRETRS
..  |. . . |.  . |  . |.|.. .|..     .| . .|| ||..|..|||.. .. ..|    |... | . . |. | 
rkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRp
PTPc_SM00194 127-202 2.2e-07 25.8 In-house 158-242 (263) alignment 
Range on Protein: 127-202
Range on HMM: 158-242/263.0
FEYLQIDILDLPETRIIDYFERVFEFIDKVRQN----EGIVFIHCNAGISRSATFVVAYLM-KNL----KISCREAMDKCRETRS
..  |. . . |.  . |  . |.|.. .|..     .| . .|| ||..|..|||.. .. ..|    |... | . . |. | 
rkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRp
subfamily_DSP23_pd Subfamily DSP23 130-202 2.3e-08 28.8 In-house 57-126 (148) alignment 
Range on Protein: 130-202
Range on HMM: 57-126/148.0
LQIDILDLPETRIIDYFERVfefIDKVRQNEGIVFIHCNAGISRSATFVVAYLMKNLKISCREAMDKCRETRS
|.||    |    .. | ||   ...  ...  | .||  |  |. |..  ||.|. |..  ||. . |. | 
lriddyhppaleqvvefvrv...veeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrp
subfamily_Laforin_pd Subfamily Laforin 130-191 6e-07 22.5 In-house 80-141 (183) alignment 
Range on Protein: 130-191
Range on HMM: 80-141/183.0
LQIDILDLPETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLMKNLKISCR
. . . ||     .. . .   ..  . ..  ||..|||||. ||.. |. .|.  |. | .
iwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwsla
Y_phosphatase Protein-tyrosine phosphatase 136-219 7.6e-09 30.7 Pfam-A 142-229 (235) alignment 
Range on Protein: 136-219
Range on HMM: 142-229/235.0
DLPETRIIDYFERVFEFIDKVRQNE----GIVFIHCNAGISRSATFVVAYLMKNLKIS--CREAMDKCRETRSIRPntGFAQQLKEYEAI
. |.  . .  . ....|.||....    | | .|| ||..|..|||.. .. .   .  . . .. ..| |. ||  |  |.|..|...
nWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRp..gmvqsleqYifl
Y_phosphatase Protein-tyrosine phosphatase 136-219 7.6e-09 30.7 In-house 142-229 (235) alignment 
Range on Protein: 136-219
Range on HMM: 142-229/235.0
DLPETRIIDYFERVFEFIDKVRQNE----GIVFIHCNAGISRSATFVVAYLMKNLKIS--CREAMDKCRETRSIRPntGFAQQLKEYEAI
. |.  . .  . ....|.||....    | | .|| ||..|..|||.. .. .   .  . . .. ..| |. ||  |  |.|..|...
nWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRp..gmvqsleqYifl
subfamily_RNGTT_pd Subfamily RNGTT 137-202 9.3e-08 26.0 In-house 91-155 (189) alignment 
Range on Protein: 137-202
Range on HMM: 91-155/189.0
LPETRIIDYFERVFEFIDKvRQNEGIVFIHCNAGISRSATFVVAYLMKNLKISCREAMDKCRETRS
 ||.  .. | .. |   | .. | .. .||  |  |.  ..|.||... ..| ..|..  ...| 
aPeaeqvkefiklveeffk.knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRp
0048567 (Phosphotyrosine protein) phosphatases II 138-201 1.2e-10 36.0 In-house 52-118 (157) alignment 
Range on Protein: 138-201
Range on HMM: 52-118/157.0
PETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGI---SRSATFVVAYLMKNLKISCREAMDKCRETR
. ....... .. .|.. .. ... . .|| ||    .|.||.. .||.. |... .||..  |  |
nlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivr
subfamily_DSP11_pd Subfamily DSP11 138-202 1.7e-08 28.5 In-house 93-158 (178) alignment 
Range on Protein: 138-202
Range on HMM: 93-158/178.0
PETRIIDY-FERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLMKNLKISCREAMDKCRETRS
|.  ...   |.| ||..|  .|. .. .||  |. |.  ..  ||..   .. ..|...  |.| 
pkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearG
subfamily_PTPRD_pd Subfamily PTPRD 138-183 9e-06 19.6 In-house 188-237 (564) alignment 
Range on Protein: 138-183
Range on HMM: 188-237/564.0
PETRIIDYFERVFEFIDKVR----QNEGIVFIHCNAGISRSATFVVAYLM
|.. . .. . . ..|.|||    ...| . .||.||. |. ||.|   |
PdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividam
subfamily_MSG5_pd Subfamily MSG5 139-220 6.8e-15 48.6 In-house 78-160 (165) alignment 
Range on Protein: 139-220
Range on HMM: 78-160/165.0
ETRIIDYFERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLMKNLKISCREAMDKCRE-TRSIRPNTGFAQQLKEYEAIL
...|.  . |. . |   . ..  ...||. |.||||...|||.||  ..| |.| || .  .  | |. |.  || |.|..|
dskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmeweval
subfamily_Ptp69D_pd Subfamily Ptp69D 140-218 1.9e-06 22.2 In-house 195-277 (307) alignment 
Range on Protein: 140-218
Range on HMM: 195-277/307.0
TRIIDYFERVFEFIDKV----RQNEGIVFIHCNAGISRSATFVVAYLMKNlKISCREAMDKCRETRSIRPN-TGFAQQLKEYEA
. . .  . ....|..|    ..|.. . .||.|| .||..||   .. . ..   . .| .  .. .| . . . |.|. |. 
skvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllq.qlkaedkvdifetvkdLrsqRnllvqsleqYvf
subfamily_PTPN6_pd Subfamily PTPN6 141-187 6.2e-06 20.4 In-house 207-255 (306) alignment 
Range on Protein: 141-187
Range on HMM: 207-255/306.0
RIIDYFERVFEFIDKVR-QNEGIVFIHCNAGISRSATFVVAY-LMKNLK
 ..|..| | .  .... ...| . .||.||| |  ||.|   |.|...
avLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillklie
subfamily_PTEN_pd Subfamily PTEN 147-202 2.2e-07 26.0 In-house 103-157 (184) alignment 
Range on Protein: 147-202
Range on HMM: 103-157/184.0
ERVFEFIDKvrQNEGIVFIHCNAGISRSATFVVAYLMKNLKISCR-EAMDKCRETRS
| . .....  ... .| .||.||  |. . .||||.|.|...   ||..   |.|.
ediekwlee..dkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRt
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 147-206 7e-06 19.9 In-house 203-264 (290) alignment 
Range on Protein: 147-206
Range on HMM: 203-264/290.0
ERVFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLMKNLKISCRE--AMDKCRETRSIRPN
  ..  .  .|.  | | .|| ||| |. |||      .. .  .|   .| .|  |  | |
lallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrln
subfamily_CDC14_pd Subfamily CDC14 149-201 2.4e-09 31.5 In-house 252-304 (328) alignment 
Range on Protein: 149-201
Range on HMM: 252-304/328.0
VFEFIDKVRQNEGIVFIHCNAGISRSATFVVAYLMKNLKISCREAMDKCRETR
| .|.. . . || . .|| ||. |  |.. .||||. ...  ||.   | .|
vkkfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricr
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 149-181 5.1e-06 20.8 In-house 180-212 (290) alignment 
Range on Protein: 149-181
Range on HMM: 180-212/290.0
VFEFIDKVRQNEGIVFIHCNAGISRSATFVVAY
. . |.||....  | .||  ||||||..    
llsliqkvkasktpvivHcvdGiSrsAalaaii
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 151-205 3.9e-06 21.1 In-house 200-257 (307) alignment 
Range on Protein: 151-205
Range on HMM: 200-257/307.0
EFIDKVRQNEGIVFIHCNAGISRSATFVV-AYLMKNL--KISCREAMDKCRETRSIRP
.... || ..  | .|| ||. || | |  ....  .   | |..  .  .| || |.
nlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrh
subfamily_PTPDC1_pd Subfamily PTPDC1 159-205 4.1e-07 24.6 In-house 113-161 (182) alignment 
Range on Protein: 159-205
Range on HMM: 113-161/182.0
NEGIVFIHCNAGISRSATFVVAYLMKNLKISCREAMDKCRETRS--IRP
.|| | .|| ||  |    . .||. . ...  .|... |. |.  |..
qegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqt