Gene Mkp in Drosophila melanogaster

Synonym: CG34099, CG7042, DMKP, Dmel\CG34099, MKP, mkp, Dmel_CG34099, Mkp

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP19
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP020_AA protein Get Run
DmelP020_AA_64-201 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP1_pd Subfamily DSP1 53-201 1e-34 114.0 In-house 4-151 (163) alignment 
Range on Protein: 53-201
Range on HMM: 4-151/163.0
EYGFVVDTKPDSVPACILSDFLYLGSQDAVSADNI-IKYKITHILSVGIQTPEVEWPlPVNCTFLPCLDLPETNLMNYILpASMEFIEDAHRSQGCVLVH
. |  .|...   | ... |||||||.   |  .|  . .||.|| |  ....|      .   |.  | |. ... ..    .|||.......| ||.|
wlgcdldklklydPvekildfLylGsetvasnleiLkslgitailnvskeldnvfed.lfeYkklkleDspkadislvfe.eviefidevkkknGkvlih

CNAGVSRSPSVVIGYLMQRRDMCYEDAYNLVKSWRPCIQPNAGFIQQLKR
|.||.||| .... |||... . .|.|...||. |..|.|||||..||..
CqaGisRsstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLln
subfamily_DSP19_pd Subfamily DSP19 55-202 7.2e-61 199.0 In-house 1-146 (152) alignment 
Range on Protein: 55-202
Range on HMM: 1-146/152.0
GFVVDTKPDSvPACILSDFLYLGSQDAVSADNIIKY-KITHILSVGIQTPEVeWPLPVNCTFLPCLDLPETNLMNYiLPASMEFIEDAHRSQGCVLVHCN
|||.|.|.|.  .. ... |||||||......|.|. ||||||.|....|.| .|  .... ...||||||.|..| |.....|||.|....|.||||||
gfveDlkedl.evgeveprlylgsqdvaadkeilkekkitHilnvatgvpnv.fpkdftylsieilDlpetdllsy.lkealdFieearskdgavlvHCn

AGVSRSPSVVIGYLMQRRDMCYEDAYNLVKSWRPCIQPNAGFIQQLKRS
||||||.||||.|||.......|.|..||...||||.||.|||.|||..
AGvSRsasvviaylmkkeelsleealelvrearpcikPneGFikqLkey
PTEN_1 57-201 2.6e-19 64.8 In-house 30-186 (196) alignment 
Range on Protein: 57-201
Range on HMM: 30-186/196.0
VVDTKPDSVPAC-ILSDFLYLGSQDAVSADNIIKYK--ITHILSVGIQTPE--VEWP------LPVNCTFLPCLDLPETNLMNYIL-PASMEFIEDAHRS
....|. |.| .  ....||.||.. |.||   ...  ||.....    ..  ....        |.   .|  | .  .|   .   .|..    ....
iamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpn

QGCVLVHCNAGVSRSPSVVIGYLMQRRDMCYEDAYNLVKSWRPCIQPNAGFIQQLKR
...||||| ||..||  ||. |||... . ...|  ||.. ||.. || .. ..|..
gnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlle
subfamily_DSP10_pd Subfamily DSP10 63-200 4.5e-35 114.9 In-house 10-147 (159) alignment 
Range on Protein: 63-200
Range on HMM: 10-147/159.0
DSVPACILSDFLYLGS-QDAVSADNIIKYKITHILSVGIQTPEVEWPLPVNCTFLPCLDLPETNLMNYIlPASMEFIEDAHRSQGCVLVHCNAGVSRSPS
...||  .  ||.||| .|| . | . ...||..| |  ..|       ..   .|  |  . || .|   ...||||.|....  |||||.||.||| .
etapasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyf.eealefieearkkgsrvLvhCqaGisrsat

VVIGYLMQRRDMCYEDAYNLVKSWRPCIQPNAGFIQQLK
|||.|||.....  .|||..||. || | || .|. ||.
vviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLl
subfamily_DSP6_pd Subfamily DSP6 63-200 1.2e-31 103.4 In-house 11-148 (158) alignment 
Range on Protein: 63-200
Range on HMM: 11-148/158.0
DSVPACILSdFLYLGSQ-DAVSADNIIKYKITHILSVGIQTPEVEWPLP-VNCTFLPCLDLPETNLMNYiLPASMEFIEDAHRSQGCVLVHCNAGVSRSP
...|. ||. .|||||. ||   . . |.|| ..| |  . |..    . .. . .|  |  ..||... .| ..|||..|....  ||||| ||.||| 
aefpveilp.llylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakf.fPeaiefidearskkskvlvhClaGisrsv

SVVIGYLMQRRDMCYEDAYNLVKSWRPCIQPNAGFIQQLK
 |.. |||... .  .|||.|||. .. | ||  |..||.
tvtlaylmkklalslndaydlvkkrksnisPnfnfmgqll
subfamily_MKPLT_pd Subfamily MKPLT 63-200 2.1e-27 89.7 In-house 18-154 (164) alignment 
Range on Protein: 63-200
Range on HMM: 18-154/164.0
DSVPACILSDFLYLGSQDAVSADNIIK-YKITHILSVGiQTPEVEWPLPVNCTFLPCLDLPETNLMNYILpASMEFIEDAHRSQGCVLVHCNAGVSRSPS
 . |. .| | ||||  . .  ....|  |||||. |  |     .|  |.   .   | ....|....     .|. ||  | |.|||||. |.||| |
kiypsvvledtlylGnakhatnekvlkdlkithivnvs.qekkdafpksveYlqvkvedesdeqlssfle.raakfladaidsGGrvlvhcvqGksrsss

VVIGYLMQRRDMCYEDAYNLVKSWRPCIQPNAGFIQQLK
| . .|.. .   ...||. .|  | ...|| ||..|| 
vtvafLikskgwtlkeayeylkerrsivapnrGflkqla
subfamily_MKPLV_pd Subfamily MKPLV 63-200 2.1e-27 89.7 In-house 18-154 (164) alignment 
Range on Protein: 63-200
Range on HMM: 18-154/164.0
DSVPACILSDFLYLGSQDAVSADNIIK-YKITHILSVGiQTPEVEWPLPVNCTFLPCLDLPETNLMNYILpASMEFIEDAHRSQGCVLVHCNAGVSRSPS
 . |. .| | ||||  . .  ....|  |||||. |  |     .|  |.   .   | ....|....     .|. ||  | |.|||||. |.||| |
kiypsvvledtlylGnakhatnekvlkdlkithivnvs.qekkdafpksveYlqvkvedesdeqlssfle.raakfladaidsGGrvlvhcvqGksrsss

VVIGYLMQRRDMCYEDAYNLVKSWRPCIQPNAGFIQQLK
| . .|.. .   ...||. .|  | ...|| ||..|| 
vtvafLikskgwtlkeayeylkerrsivapnrGflkqla
0044763 (Phosphotyrosine protein) phosphatases II 64-201 2.1e-33 110.8 In-house 20-165 (178) alignment 
Range on Protein: 64-201
Range on HMM: 20-165/178.0
SVPACILSDFLYLGSQDAVS-ADNIIKYKITHILSVGIQTP------EVEWPLP--VNCTFLPCLDLPETNlMNYILPASMEFIEDAH-RSQGCVLVHCN
  .|.   ..|||||. ...  . . ...||||...   ..        .||    ..  ..|. | .... .  .... .||||.|. ...|.|||||.
yinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpd.llehflefvefieealdekggpvlVHCs

AGVSRSPSVVIGYLMQRRDMCYEDAYNLVKSWRPcIQPNAGFIQQLKR
|||.||...|. ||| ......|.|..||.. || |.|| |...||..
aGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLye
subfamily_LRR-DSP_pd Subfamily LRR-DSP 64-201 1.2e-27 90.7 In-house 118-253 (263) alignment 
Range on Protein: 64-201
Range on HMM: 118-253/263.0
SVPACILsDFLYLGSQDAVSADNIIK-YKITHI-LSVGIQTPevEWPLPVNCTFL-PCLDLPETNLMNYILPaSMEFIEDAhRSQGCVLVHCNAGVSRSP
|||  |. | |.||..|.    .|.|   .||| |.|.   |   .|       .    | .| .. ..       |||.  | .| ||||| |||||| 
svPdeii.dklflGgldsannksilkdlgvthillavadfeP..lfPklfkylsiddiedvdeadisqhfee.tnafieeG.rkkGGvlvhcraGvsrss

SVVIGYLMQRRDMCYEDAYNLVKSWRPCIQPNAGFIQQLKR
..|| |||... . ...|..||.. || |||| ||..|||.
tlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkk
subfamily_STYXL1_pd Subfamily STYXL1 65-201 7.1e-22 71.3 In-house 10-148 (157) alignment 
Range on Protein: 65-201
Range on HMM: 10-148/157.0
VPACILSDFLYLGSQDAVSADNIIK-YKITHILSVGIQTPEVEWPLPV--NCTFLPCLDLPETNLMNYiLPASMEFIEDAHRSQGCVLVHCNAGVSRSPS
 |  .| ..||||        .| |  |.   . |  .. ..   ..   .   ..  | .|..|..  |   ..|||. .... .|||  | |.||| .
yPvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadller.lkeavqfiekhkkegevvlvfsnkGisrsaa

VVIGYLMQRRDMCYEDAYNLVKSWRPCIQPNAGFIQQLKR
|.|.|||  ... ...||. .|  .. ..|| .|..||..
viiaylmyskkitlkkaykylkkCkenvkPnrafveqlse
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 65-200 8.3e-21 68.0 In-house 6-141 (148) alignment 
Range on Protein: 65-200
Range on HMM: 6-141/148.0
VPACILSDFLYLGSQD-AVSADNIIKYKITHILSVGIqtpEVEWPLPVNCT---FLPCLDLPETNLmNYILPASMEFIEDAHRSQGCVLVHCNAGVSRSP
 |. |   ||.|||.  | ... . .  .|.| .      | . .| .       ..  | |. .| . | .  ..|.. |.   . ||||.. ||||| 
fpseikdafLFlGskksaadlealkalgvtrivnatk...erdnaldqrgieYlhvaldDkpkedl.saiFediiafvrkakdeGrrvLvhlqmGvsrss

SVVIGYLMQRRDMCYEDAYNLVKSWRPCIQPNAGFIQQLK
 ... .|.. ...  ..|..|||| |. ..|| ||..|| 
alallwlidfkrvslkealalvkskrryvdpnlgfLkqLa
0048179 (Phosphotyrosine protein) phosphatases II 66-201 2.2e-29 97.4 In-house 4-139 (144) alignment 
Range on Protein: 66-201
Range on HMM: 4-139/144.0
PACILSDfLYLGSQD-AVSADNIIKYKITHILSVGIQTPEVEWPLPV-NCTFLPCLDLPETNLMNYILpASMEFIEDAHRSQGCVLVHCNAGVSRSPSVV
|..||.. |||||.  |.. ... |..||.....  . .  ..  .. .  .||. | .  .|....| . .||||.|... |.|||||.|||.|....|
pseilpg.lylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllelll.eflefieealeeggpvlVHCsaGvgRtgtlv

IGYLMQRRDMCYEDAYNLVKSWRPCIQPNAGFIQQLKR
. ||| ......|.|..||.| ||.. || |....|..
aaylmkklglsleealalvrsrrpgavpnpgqlrfLle
0045098 (Phosphotyrosine protein) phosphatases II 68-201 1.1e-23 79.5 In-house 23-266 (278) alignment 
Range on Protein: 68-201
Range on HMM: 23-266/278.0
CILSDFLYLGSQD------------------------------------------AVSADNIIKYKITHILSVG--------------------------
.  ...||||..|                                          |   . . ...||.|...                           
seitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdft

-------------------------IQTPEVEWPLPVNCTFLPCLDLPETNLMNYILpASMEFIEDAHR--------------SQGCVLVHCNAGVSRSP
                          .. |      ..... |  . |........|   .|||..|..              |.|.|||||.|||.|. 
vtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksfl.ellefirealkllaslllsslllldsggpvlVHCsaGvgRtG

SVVIGYLMQRR---DMCYEDAYNLVKSWRPC-IQPNAGFIQQLKR
 .|. ||| ..    .....|.. ..| ||. ...| .....| .
tlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflye
0041856 (Phosphotyrosine protein) phosphatases II 69-200 6.4e-27 89.7 In-house 21-166 (182) alignment 
Range on Protein: 69-200
Range on HMM: 21-166/182.0
ILSDFLYLGSQD---------------AVSADNIIKYKITHILSVGiqtPEVEWPLPV-----NCTFLPCLDLPETNlmnyiLPASMEFIEDAHRSQGCV
   . |||||.                |   . . ...||.|...    .|  ||  .     .  .||. | . ..     |.   .|||......|.|
yInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt...eelywpellerlgiqylylpwpDhgvpd.....ldelldfieevleeggpv

LVHCNAGVSRSPSVVIGYLMQRRDMCYEDAYNLVKSWRP--CIQPNAGFIQQLK
||||.|||.|....|. ||| .... .|.|..||.| ||  .|.|| .|. ||.
lVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqla
subfamily_Slingshot_pd Subfamily Slingshot 69-201 7.7e-26 84.5 In-house 21-152 (169) alignment 
Range on Protein: 69-201
Range on HMM: 21-152/169.0
ILSDFLYLGSQ-DAVSADNIIKYKITHILSVGIQTPEVeWPLPVNCTFLPCLDLPETNLMNYIlPASMEFIEDAHRSQGCVLVHCNAGVSRSPSVVIGYL
 . |..||||. .|   ... . ....|| |  .  .  .|  .. . .   | .||.|..|    . .||| |....  |||||  ||||| |.|| | 
kifdhvylGsewnasnleelkengveyilnvtkeidnf.fpekfeylnirvydeeetdllkyw.netykfiekakkkgskvlvhckmGvsrsastviaya

MQRRDMCYEDAYNLVKSWRPCIQPNAGFIQQLKR
|.. .. .|.|.. ||. | .|.||.||..||. 
mkeyglsleealeyvkerrsvikPnkgflkqlee
subfamily_MSG5_pd Subfamily MSG5 69-200 2e-15 50.3 In-house 29-154 (165) alignment 
Range on Protein: 69-200
Range on HMM: 29-154/165.0
ILSDFLYLGSQDAVsaDNIIKYKIthILSVGIQTPEVEWPLPVnCTFLpCLDLPETNLMNYILPASMEFIEDAHRSQGCVLVHCNAGVSRSPSVVIGYLM
.| . ||| |.  .  .... . .  .. |  . ...|  .|    .   ..   .  .   |.   . |  |.  .  .||||. |.||| |... |.|
vlpeklylysepkl..kellsfdl..vinvakeindlellvpa.vkyy.hiewehdskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayim

QRRDMCYEDAYNLVKSWRPCIQPNAGFIQQLK
.  ..  .|||...||    |.|. |.| || 
kyynlslrdaydklksvaddispsiglifqlm
PTPc_motif_SM00404 70-200 8e-32 105.0 In-house 6-135 (140) alignment 
Range on Protein: 70-200
Range on HMM: 6-135/140.0
LSDfLYLGSQDAVS-ADNIIKYKITHILSVGIQTPEVEWPLPVNCTFLPCLDLPETNLMNYiLPASMEFIEDAHRSQGCVLVHCNAGVSRSPSVVIGYLM
| . |||||... . .. . |..|||...|. . .  .    ..   .|  |  ...| .| |.. ..|||.|....| ||||| |||||| ...| |||
lph.lylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklsky.ldkvldfienaekkggkvlVHCqaGvSRSatliiaYlm

QRRDMCYEDAYNLVKSWRPCIQPNAGFIQQLK
..| . ...||..||. ||.|.||..|..|| 
ryrqlslaeayefvkerRpiispnlnfvrqLi
subfamily_DSP8_pd Subfamily DSP8 70-199 3e-30 98.9 In-house 18-147 (159) alignment 
Range on Protein: 70-199
Range on HMM: 18-147/159.0
LSDFLYLGSQDA-VSADNIIKYKITHILSVGIQTPEVEWPLPVNCTFLPCLDLPETNLMNYiLPASMEFIEDAHRSQGCVLVHCNAGVSRSPSVVIGYLM
. ..||||||   .| . . |. |...| .  . |..|    ..   .|  |  . .|... ...|.|||. |....|.||||. || |||..|.|.|.|
ilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpw.fdksvefidkaksengrvlvhvlaGisrsatvaiayim

QRRDMCYEDAYNLVKSWRPCIQPNAGFIQQL
.. .| ...||. ||. || |.||  |..||
ktlemsldeayrfvkekrptispnlnflgqL
0036282 (Phosphotyrosine protein) phosphatases II 70-200 2e-21 71.9 In-house 15-163 (174) alignment 
Range on Protein: 70-200
Range on HMM: 15-163/174.0
LSDFLYLGSQDAVSADNIIKYKITHILSVGIQTP--------------EVEWPLPVNCTFLPCLDLPETNLMNyiLPASMEFIEDAHRS--QGCVLVHCN
 .. |..|.  .   . . ...||.....    .              | . .| ..  .||. |  . .|    |   ..|.|.|. .  .|.|||||.
itprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi..llefvkfveealsedpggpvlVHCs

AGVSRSPSVVIGYLMQRRDM-CYEDAYNLVKSWR---PCIQPNAGFIQQLK
|||.|.. .|. ||| |. .  ..||..||.. |   |.. .. .....| 
aGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrfly
0051429 (Phosphotyrosine protein) phosphatases II 70-201 6.1e-15 51.1 In-house 20-219 (272) alignment 
Range on Protein: 70-201
Range on HMM: 20-219/272.0
LSDFLYLGSQ----DAVSADNIIKYKITHILSVG------IQTPEVEWpLPVNCTFLPCLDLPETNLMNYI-----------------------------
. ..||....    .| . . . ...|..|...        .  . .|   ..  .||.||  ..    .                              
kpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdryw.pgirylhlpilddsaptilygalrvtllseellldyilrellltlllsage

------------------LPASMEFIEDAHRsQGCVLVHCNAGVSRSPSVVIGYLMQrRDMC--------------YEDAYNLVKSWRPCIQPNAGFIQQ
                    |  |..|  .. .| |||||.||..|.  ||  .|.  ....              .|.|.. ... ||.. .. .....
arevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylf

LKR
| .
lye
subfamily_DSP14_pd Subfamily DSP14 71-201 7e-34 111.0 In-house 11-139 (157) alignment 
Range on Protein: 71-201
Range on HMM: 11-139/157.0
SDFLYLGSQDAVSADNIIKYKITHILSVGIQTPEVEWPlPVNCTFLPCLDLPETNLMNYILPAsMEFIEDAHRSQGCVLVHCNAGVSRSPSVVIGYLMQR
 . |.|... |.| . . |.|||.|. | ...|. ...  .. . .|  | ||..|...  .. .. ||......|..|||| |||||| |... |||. 
tpsLflsgvaalskellkkkkitliinvtvelpntklk.diervkvpveDnpeaklakhfdev.adkieevkkkggktlvhCvaGvSRSAslclaylmky

RDMCYEDAYNLVKSWRPCIQPNAGFIQQLKR
. .. ..||.|||| || |.|| || .|| .
eklsLreayklvksaRpiirPNvGFwkqlid
0048076 (Phosphotyrosine protein) phosphatases II 71-201 7.1e-30 99.0 In-house 8-137 (145) alignment 
Range on Protein: 71-201
Range on HMM: 8-137/145.0
SDFLYLGSQD-AVSADNIIKYKITHILSVgIQTPEVEWPLPVNCTFLPCLDLPETNLMNYILpASMEFIEDAHRSQGCVLVHCNAGVSRSPSVVIGYLMQ
 . |||||.  |.. ... ...||..|..   ..| . .| ..  .||. | .. .|....| . .||||.|... |.|||||.|||.|....|. ||| 
lpglylgslptaldlellkdlgittvlnl.tselellerlgiqylylpwpDhgvpdllelll.eflefieealkeggpvlVHCsaGvgRtgtlvaaylml

RRDMCYEDAYNLVKSWRPCIQPNAGFIQQLKR
.... .|.|..||.| ||.. || |....|..
llgvsleealelvrsqrpgavpnpgqlrflye
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 71-201 2.3e-26 86.0 In-house 7-147 (154) alignment 
Range on Protein: 71-201
Range on HMM: 7-147/154.0
SDFLYLGSQDAVSAD-NIIKYKITHILSVGIQTPEV--------EWPLPVNCTFLPCLDLPETNLMNYiLPASMEFIEDAH--RSQGCVLVHCNAGVSRS
. |||..|.||     .. ...|..|| ||| ....        .  . ..   |   | .. ....  |  ..|||.||     .. ||||...|||||
aiflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiek.ldkafefiddaiggvennkvlvhsdkGvsrs

PSVVIGYLMQRRDMCYEDAYNLVKSWRPCIQPNAGFIQQLKR
 ...|.|||... . .  |. |.|. |. |.|| ||..||..
aallisylmdklkislslalellkdsryiikPnqGflkqlei
subfamily_DSP12_pd Subfamily DSP12 72-200 1.8e-35 116.7 In-house 7-137 (155) alignment 
Range on Protein: 72-200
Range on HMM: 7-137/155.0
DFLYLGSQDAVSA-DNIIKYKITHILSVGIQT-P-EVEWPLPVNCTFLPCLDLPETNLMNYiLPASMEFIEDAHRSQGCVLVHCNAGVSRSPSVVIGYLM
. ||||.  ||   ..  ..||||.|||  .. | . . .  |.. |...|| ||...... |.  ..|||.|   .| |||||.|||||| ..|| |||
pglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLsh.ldeavdFieealeeegavlvHCqagvSRSvtiviAYlm

QRRDMCYEDAYNLVKSWRPCIQPNAGFIQQLK
.. ..  |.|..|||. .| |.||.||..|||
kkeklslekAlklvkekkpeiepNegFleQLk
DSPc Dual specificity phosphatase, catalytic domain 74-200 1.4e-30 100.8 Pfam-A 1-128 (133) alignment 
Range on Protein: 74-200
Range on HMM: 1-128/133.0
LYLGSQDAVSADNIIKYKITHILSVGIQTPE--VEWPLPVNCTFLPCLDLPETNLMNYiLPASMEFIEDAHRSQGCVLVHCNAGVSRSPSVVIGYLMQRR
|||||. . | . . |..||....|  ..|.     .   . . .|  |  ||.. .. |....||||.|..... |||||.||.|||....| |||...
lylgskstaslalleklgitlvinvtkevpnnnaikkseieylripvedetetkiske.leeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

DMCYEDAYNLVKSWRPCIQPNAGFIQQLK
 . ...||..||. |..| |||||..|| 
nlslneAyefvkerrskispnagflrqLl
DSPc Dual specificity phosphatase, catalytic domain 74-200 1.4e-30 100.8 In-house 1-128 (133) alignment 
Range on Protein: 74-200
Range on HMM: 1-128/133.0
LYLGSQDAVSADNIIKYKITHILSVGIQTPE--VEWPLPVNCTFLPCLDLPETNLMNYiLPASMEFIEDAHRSQGCVLVHCNAGVSRSPSVVIGYLMQRR
|||||. . | . . |..||....|  ..|.     .   . . .|  |  ||.. .. |....||||.|..... |||||.||.|||....| |||...
lylgskstaslalleklgitlvinvtkevpnnnaikkseieylripvedetetkiske.leeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

DMCYEDAYNLVKSWRPCIQPNAGFIQQLK
 . ...||..||. |..| |||||..|| 
nlslneAyefvkerrskispnagflrqLl
subfamily_DSP15_pd Subfamily DSP15 74-201 8.9e-25 81.5 In-house 9-134 (151) alignment 
Range on Protein: 74-201
Range on HMM: 9-134/151.0
LYLGS-QDAVSADNIIKYKITHILSVGIQTPEVEWPlpVNCTFLPCLDLPETNLMNYIlPASMEFIEDAHRSQGCVLVHCNAGVSRSPSVVIGYLMQRRD
||||  .|.  .. . . .|||||||  .. ..     ..  ...  | |...|....   |.||| ..   .. ||||| ||||||  .|. |||   .
lylgnfrdskdeelLkeknithilsvhdnakkllkd..ieYkciaasDtpsaklskff.kesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtvte

MCYEDAYNLVKSWRPCIQPNAGFIQQLKR
. ..|| . .|  | . .||.|| .||| 
lnwrdalevikaaRsvanPnfGfkrqlke
subfamily_DSP3_pd Subfamily DSP3 74-201 1.6e-23 77.2 In-house 18-152 (162) alignment 
Range on Protein: 74-201
Range on HMM: 18-152/162.0
LYLGSQD-AVSADNIIKYKITHILSVG------IQTPE-VEWPLPVNCTFLPCLDLPETNLMNYILPASmEFIEDAHRS-QGCVLVHCNAGVSRSPSVVI
||.| .. |   ... |  |||.|         ..| .     | .. . |.  | ||..| .|  .|. .||..|  . .| |||||..|||||. .|.
lyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaa.kfidealsqkegkvlvhcvvGvsRsatlvl

GYLMQRRDMCYEDAYNLVKSWRpCIQPNAGFIQQLKR
 ||| ||.|   .| . |.. | .|.|| ||..||. 
ayLmirrkmtlveairtvrkkR.eilPneGFlkqLae
0046846 (Phosphotyrosine protein) phosphatases II 75-200 1.5e-22 75.6 In-house 20-166 (176) alignment 
Range on Protein: 75-200
Range on HMM: 20-166/176.0
YLGSQ-----------DAVSADNIIKYKITHILSVG----------IQTPEVEWPLPVNCTFLPCLDLPETNLmnYILPASMEFIEDAHRSQGCVLVHCN
.|||             |   . . ...||.....            . ..... | .   .||  |    .|   .|.  .|||..| .. |.||||| 
ilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl..elllellefirealkeggpvlVHCs

AGVSRSPSVVIGYLMQR-RDMCYEDAYNLVKSWRP-CIQPNAGFIQQLK
||..|.. .|. ||... ... .|.|. ||.. || .. .. .....|.
aGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrfly
0051082 (Phosphotyrosine protein) phosphatases II 75-199 2.6e-17 58.3 In-house 16-146 (151) alignment 
Range on Protein: 75-199
Range on HMM: 16-146/151.0
YLGSQ-DAVSADNIIKYKITHILSVGIQTPEV----EWPL-PVNCTFLPCLDLPETNLMNYiLPASMEFIEDAHRS-QGCVLVHCNAGVSRSPSVVIGYL
|....  |   . . ...|..|...   ..       .|   .. . .|.|| |...|  . ..| .||.| . .  .|.|||||.||..|.  .|. ||
yrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglpls.fdavleflellldkkngpvlvHCsaGkgRTGtlvalyl

MQrRDMCYEDAYNLVKSWRP-CIQPNAGFIQQL
|  .....|.|.. ... || ..||| .|. ||
ml.lgvsleealeeyrlkrpgvvqpnqqflfql
0043147 (Phosphotyrosine protein) phosphatases II 76-200 4.4e-28 93.6 In-house 29-154 (172) alignment 
Range on Protein: 76-200
Range on HMM: 29-154/172.0
LGSQDAVSADNIIKYKITHILSVGiQT---PEVEWPLPVNCTFLPCLDLPETnlMNYILPASMEFIED--AHRSQGCVLVHCNAGVSRSPSVVIGYLMQr
|.. .|   . . ...||||...  .    || ...| .   .||. | . .  .  .|.  .|||..  | ...|.||||| |||.|.. .|. |||. 
lrntladfwrmlkelgithivnlt.ellydpellerlgiqylylpwpDhgvp..llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.

RDMCYEDAYNLVKSWRPCIQPNAGFIQQLK
... .|.|..||.. ||.. .| .....|.
lglsleeavalvrekRpgavqnpsqyrfly
0049772 (Phosphotyrosine protein) phosphatases II 80-201 1.8e-27 92.3 In-house 156-268 (314) alignment 
Range on Protein: 80-201
Range on HMM: 156-268/314.0
DAVSADNIIKYKithilsvGIQTPEVEWPLP-VNCTFLPCLDlPETNLMNYILPAsMEFIEDAhRSQGCVLVHCNAGVSRSPS-VVIGYLMQRRDMCYED
.  .| ..  .|       .....   .. . ..   .|. | ....| .... . .||||.| . .|.|||||.||..|... ||..||| ......|.
neptaadlellk.......eelydpelferlgikylripvpD.gsaplledfdef.lefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvslee

AYNLVKSWRPcIQPNAGFIQQLKR
|.. |.. || |.|| |||.||..
aledvrlkRp.inpnpgfieqleq
0049260 (Phosphotyrosine protein) phosphatases II 85-200 7.1e-24 79.6 In-house 27-143 (152) alignment 
Range on Protein: 85-200
Range on HMM: 27-143/152.0
DNIIKYKITHILSVGIQTPEVE--WPLPVNCTFLPCLDLPETNLMNYILPASMEFIEDAHRSQGCVLVHCNAGVSRSPSVVIGYLMQrRDMCYEDAYNLV
. . ...||.|...   ..  .  ..   .  .||. | .  .|  ..| .     . |....|.||||| |||.|.. .|. |||  ... .|.|..||
rmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.lgvsleeavalv

KSWRPCIQPNAGFIQQLK
.. ||.. || |....|.
rekRpgavpnpgqlrfly
subfamily_STYX_pd Subfamily STYX 85-201 3e-23 75.7 In-house 33-152 (166) alignment 
Range on Protein: 85-201
Range on HMM: 33-152/166.0
DNIIKYKITHILSVGiQTPEVEWPL---PVNCTFLpCLDLPETNLMNYI--LPASMEFIEDAHRSQGCVLVHCNAGVSRSPSVVIGYLMQRRDMCYEDAY
. . |  ||||. .  |..| .      | .  .|  ||. .. . | |  ||   |||.|. .. | |||| |||.||| ..||.|.|.   . | .|.
evlkkhgithivcir.qnieanlikpnfpdrfryl.vldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyreaf

NLVKSWRPCIQPNAGFIQQLKR
  |.  | ||.||.||..||| 
ayvqerrfcinpnegfvsqlke
0045450 (Phosphotyrosine protein) phosphatases II 87-200 1e-21 73.4 In-house 127-297 (307) alignment 
Range on Protein: 87-200
Range on HMM: 127-297/307.0
IIKYKITHILSVgiqTPE---------VEWPLP---------------------VNCTFLPCLDL-----------------PETNLMNYiLPASMEFIE
. ....|.|...   |..           ||.                      . .. |.  ||                 |....  . .    .|||
lweqgvtvivml...telvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpps.feelldfie

DAHR------SQGCVLVHCNAGVSRSPSVVIGYLMQRRD--------MCYEDAYNLVKSWRPCIQPNAGFIQQLK
 ...      ..|.|||||.|||.|...... ||| |.         .....|..|... ||.. .| .....| 
evrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrfly
0040439 (Phosphotyrosine protein) phosphatases II 87-201 2.8e-21 71.7 In-house 74-240 (249) alignment 
Range on Protein: 87-201
Range on HMM: 74-240/249.0
IIKYKITHILSVGIQTPEV------------------------------------------EWPLPVNCTFLPCLDLPETNLMNYILPaSMEFIEDAHR-
. ...||.|...   ..                                            . . .. .. ....|.|....  .. .  ..||| ..  
lwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfed.lldfieavrka

-----SQGCVLVHCNAGVSRSPSVVIGYLM-----QRRDMCYEDAYNLVKSWRPCIQPNAGFIQQLKR
     ..|.|||||.|||.|.. ... |||      ......|.|..|..| ||.. .| .....| .
leelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflye
0037934 (Phosphotyrosine protein) phosphatases II 87-200 7.7e-20 66.9 In-house 68-235 (243) alignment 
Range on Protein: 87-200
Range on HMM: 68-235/243.0
IIKYKITHILSVGIQT--------------------------------------------PEVEWPLPVNCTFLPCLD--LPE-TNLMNYILPASMEFIE
. ...||.|...   .                                            .. .  | ..  .||  |   |. .. .  .| .  ||||
lwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefie

D-----AHRSQGCVLVHCNAGVSRSPSVVIGYLMQRR-DMCYEDAYNLVKSWRPC-IQPNAGFIQQLK
.     |  |.| ||||| |||.|.  ... ||| .. .. .|.|..|... ||. . .. .....| 
ellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrfly
0042113 (Phosphotyrosine protein) phosphatases II 87-200 2.2e-18 62.0 In-house 72-236 (245) alignment 
Range on Protein: 87-200
Range on HMM: 72-236/245.0
IIKYKITHILSVGIQT---------------------------------------------PEVEWPLPVNCTFLPCLDLPETNLMNYILPAsMEFIEDA
. ...||.|...   .                                             .. |    ..  .||. | ....|....| . .||...|
lwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldf.lefvrka

HR--SQGCVLVHCNAGVSRSPSVVIGYLM-----QRRDMCYEDAYNLVKSWRPCIQPNAGFIQQLK
 .  |.| |||||.|||.|.  ... |||      ..... |.|.  ..| ||.. .. .....| 
laedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrfly
0036941 (Phosphotyrosine protein) phosphatases II 87-200 4.7e-17 57.7 In-house 98-270 (297) alignment 
Range on Protein: 87-200
Range on HMM: 98-270/297.0
IIKYKITHILSV------GIQTPEVEWPLP----------------------------------------VNCTFLPCLDLPETNLMNyILPASMEFIED
. ....|.|...      | .. .  |||                                           .| . ... |. .. .      ..||| 
vweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpe.spaslldfiel

AHR------SQGCVLVHCNAGVSRSPSVVIGYLM--------QRRDMCYEDAYNLVKSWRPCIQPNAGFIQQLK
...      |.| |||||.|||.|| .... .||         .. ... .|.. ... ||.. .. .. ..| 
vrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrfly
0040438 (Phosphotyrosine protein) phosphatases II 89-201 1e-17 59.8 In-house 108-270 (317) alignment 
Range on Protein: 89-201
Range on HMM: 108-270/317.0
KYKITHILSVGI--------------------------QTPEVEWPLPVNCTFLPCLDL----------------PETNLMNyILPASMEFIEDAHRS--
....|.|...                            .. ..|.   .. . |.. ||                |. ..    .    .|.| ....  
eqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvpp.spdllldfleavreale

--QGCVLVHCNAGVSRSPSVVIGYLM-----QRRDMCYEDAYNLVKSWRPCIQPNAGFIQQLKR
  .|.|||||.|||.|. .... |||     .......|.|.. ... ||.. .. .....| .
dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyd
0043336 (Phosphotyrosine protein) phosphatases II 89-200 1.6e-16 56.1 In-house 156-270 (278) alignment 
Range on Protein: 89-200
Range on HMM: 156-270/278.0
KYKITHILSVGIQTPEVEWPLPVNCTFLPCLDLPEtnLMNYILPASMEFIEDAHRSQGCVLVHCNAGVSRSPSVVIGYLM-----QRRDMCYEDAYNLVK
 |.....  .  ...|. . . . ..  |  ..||   .. .|    ...|  . |.|.|||||.|||.|.  ... ||.      .. ...|.|.. ..
dytvrtlevtnlgdgesrtvthyhylgwpdhgvpe..slsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelr

SWRPCIQPNAGFIQQLK
. ||.. ..  ....| 
eqRpgavqtpsqyrfly
0047943 (Phosphotyrosine protein) phosphatases II 113-199 1.3e-13 46.6 In-house 168-264 (273) alignment 
Range on Protein: 113-199
Range on HMM: 168-264/273.0
CTFLPCLDLPETNLMNyILPASMEFIEDAHR------SQGCVLVHCNAGVSRSPSVVIGYLM-----QRRDMCYEDAYNLVKSWRPCIQPNAGFIQQL
.| . ... |. .     |   .||||....      |.| |.|||.|||.|. .... .|.      .. .....|..|..| ||.. ..  ....|
vthfhytgwpdhgvpp.slesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
0051299 (Phosphotyrosine protein) phosphatases II 113-193 6.4e-12 41.0 In-house 184-272 (288) alignment 
Range on Protein: 113-193
Range on HMM: 184-272/288.0
CTFLPCLDLPETNLMNyILPASMEFIEDAHRS----QGCVLVHCNAGVSRSPSVVIGYLM-----QRRDMCYEDAYNLVKSWRPCIQPNA
.| . ... |. .  .  . . ..|.......    .|.|.|||.|||.|.  ... .|.     ... . ...|.. ... ||.. .. 
vthfhytnwpdhgvpd.spellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp
0050432 (Phosphotyrosine protein) phosphatases II 113-191 2.1e-10 35.9 In-house 199-283 (308) alignment 
Range on Protein: 113-191
Range on HMM: 199-283/308.0
CTFLPCLDLPETNLMNYiLPASMEFIEDAHRS--QGCVLVHCNAGVSRSPSVVIGYLM-----QRRDMCYEDAYNLVKSWRPCIQP
.| . ... |. .  .. . . ..|.| ...|  .| ..|||.|||.|.  ... .|.     . . . ...|.. ... ||.  .
vthfhytnWpdhgvPps.peilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvq
0038934 (Phosphotyrosine protein) phosphatases II 116-201 1e-19 66.4 In-house 85-171 (194) alignment 
Range on Protein: 116-201
Range on HMM: 85-171/194.0
LPCLD---LPETNLMNYILPASMEFIEDahRSQGCVLVHCNAGVSRSPSVVIGYLMQRRDMCYEDAYNLVKSWRPCIQPNAGFIQQLKR
||. |    | ..... .| .  ||...   ..|.|.||| ||..|.. .|. ||..|..| .|.|..|... || . || .....| .
lpfpddgtvPsleillrfldlvdeflne..dpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallk
subfamily_PTPMT1_pd Subfamily PTPMT1 116-198 2.1e-15 51.6 In-house 79-160 (171) alignment 
Range on Protein: 116-198
Range on HMM: 79-160/171.0
LPCLDLPETNLMNYIlPASMEFIEDAHRSQGCVLVHCNAGVSRSPSVVIGYLMQRRDMCYEDAYNLVKSWRPCIQPNAGFIQQ
|.  |  |.  .. .   ..||||. . .. .| |||.|| .|| ..|. |||... .  |.| . .|. |. |. .    ..
latvDfteapdlekl.ekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwka
subfamily_Laforin_pd Subfamily Laforin 116-187 3.4e-07 23.3 In-house 82-152 (183) alignment 
Range on Protein: 116-187
Range on HMM: 82-152/183.0
LPCLDLPETNLMNyILPASMEFIEDAHRSQGCVLVHCNAGVSRSPSVVIGYLMQRRDMCYEDAYNLVKSWRP
||  ||   . ..  || .. ..         | ||||||| || ..| |.|.   .         . . ||
lptedlstesrve.nlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrp
subfamily_DSP11_pd Subfamily DSP11 120-198 3.1e-06 21.2 In-house 91-169 (178) alignment 
Range on Protein: 120-198
Range on HMM: 91-169/178.0
DLPETNLMNYILPASMEFIEDAHRSQGCVLVHCNAGVSRSPSVVIGYLMQRRDMCYEDAYNLVKSWRPCIQPNAGFIQQ
..|. .|..    |  ||.|. . ..  . |||  || |.  ..  ||... ..  ||| .  .. |        ....
evpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslerenylkd
PTPc_DSPc_SM00012 122-171 9.4e-06 21.1 In-house 11-65 (105) alignment 
Range on Protein: 122-171
Range on HMM: 11-65/105.0
PETNLMNYIlPASMEFIEDAHRSQG------CVLVHCNAGVSRSPSVVIGYLMQRR
|.... ..   . .|.... ....        |.||| |||.|.  .|  ... ..
pdhgvPees.dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqq
0039614 (Phosphotyrosine protein) phosphatases II 130-200 2.3e-17 58.9 In-house 204-282 (297) alignment 
Range on Protein: 130-200
Range on HMM: 204-282/297.0
ILPASMEFIEDAHR---SQGCVLVHCNAGVSRSPSVVIGYLM-----QRRDMCYEDAYNLVKSWRPCIQPNAGFIQQLK
.|   .|....|..   ..|.|||||.|||.|. .... |||      ........|.. ... ||.. .. .....| 
llleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrfly
0046845 (Phosphotyrosine protein) phosphatases II 133-189 4.2e-10 34.9 In-house 186-256 (284) alignment 
Range on Protein: 133-189
Range on HMM: 186-256/284.0
ASMEFIEDAHRS------QGCVLVHCNAGVSRSPSVVIGYLMQRR--------DMCYEDAYNLVKSWRPCI
  .||.......      .| ..||| |||.|.  ... .|. ..         . ...|.. ... ||. 
dlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgm
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 133-169 7e-06 20.0 In-house 207-244 (305) alignment 
Range on Protein: 133-169
Range on HMM: 207-244/305.0
ASMEFIEDAHRSQGCVLVHCNAGVSRSPSVV-IGYLMQ
| .|..|.|  |.| . ||| ||. |. ||| . |...
ailellekarpskgpivvhcsagigrtgsvvmleyild
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 135-199 5.5e-12 39.0 In-house 70-134 (145) alignment 
Range on Protein: 135-199
Range on HMM: 70-134/145.0
MEFIEDAHRSQGCVLVHCNAGVSRSPSVVIGYLMQRRDMCYEDAYNLVKSWRPCIQPNAGFIQQL
 .||.  .     |.||| |||||| .| . .||.  .|.  .|   |.| |    ||  |...|
tdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllaypnvtflknl
subfamily_RNGTT_pd Subfamily RNGTT 135-189 2.2e-06 21.5 In-house 105-157 (189) alignment 
Range on Protein: 135-189
Range on HMM: 105-157/189.0
MEFIEdaHRSQGCVLVHCNAGVSRSPSVVIGYLMQRRDMCYEDAYNLVKSWRPCI
 ||..  ....  . |||  |  |.  ... ||....|.  |.| .| .. ||  
eeffk..knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppG
0048567 (Phosphotyrosine protein) phosphatases II 135-191 2.4e-06 22.0 In-house 64-123 (157) alignment 
Range on Protein: 135-191
Range on HMM: 64-123/157.0
MEFIEDAHRSQGCVLVHCNAGV---SRSPSVVIGYLMQRRDMCYEDAYNLVKSWRPCIQP
..|...     . . ||| ||    .|.  ..  ||. . ..  |.|..... .|| ..|
nkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvp
subfamily_DSP23_pd Subfamily DSP23 135-188 3e-06 22.0 In-house 74-127 (148) alignment 
Range on Protein: 135-188
Range on HMM: 74-127/148.0
MEFIEDAHRSQGCVLVHCNAGVSRSPSVVIGYLMQRRDMCYEDAYNLVKSWRPC
.. .|.|.  .  | |||  |  |. ...  ||.. |...  .|   |.  || 
vrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpg
subfamily_CDC14_pd Subfamily CDC14 136-188 2.9e-06 21.4 In-house 254-306 (328) alignment 
Range on Protein: 136-188
Range on HMM: 254-306/328.0
EFIEDAHRSQGCVLVHCNAGVSRSPSVVIGYLMQRRDMCYEDAYNLVKSWRPC
.|.| | ...| . ||| ||. |  ...  |||..  .  ..|   ..  || 
kfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPG
subfamily_PRL_pd Subfamily PRL 142-186 3.3e-06 21.2 In-house 87-130 (151) alignment 
Range on Protein: 142-186
Range on HMM: 87-130/151.0
HRSQGCVLVHCNAGVSRSPSVVIGYLMQrRDMCYEDAYNLVKSWR
.... .| ||| ||. |.| .|   |..   | |||| ..... |
eepkstvavhcvaGlGraPvlvalalie.aGmkyedavefirekr
subfamily_PTPDC1_pd Subfamily PTPDC1 144-189 3e-06 21.8 In-house 113-159 (182) alignment 
Range on Protein: 144-189
Range on HMM: 113-159/182.0
SQGCVLVHCNAGVSRSPSVVIGYLMQRRDMCYEDAYNLVKSWRPC-I
..| | ||| ||  |   ..  ||.  ...  |.| .||.| ||  |
qegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksi