Gene CG14411 in Drosophila melanogaster

Synonym: Dmel\CG14411, Dmel_CG14411, CG14411

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR10
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP028_AA protein Get Run
DmelP028_AA_312-703 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0040695 (Phosphotyrosine protein) phosphatases II 277-701 5.5e-82 269.4 In-house 6-387 (388) alignment 
Range on Protein: 277-701
Range on HMM: 6-387/388.0
MYATKNDWARELIRCGAT--EWQVVSCASvqllqnplqagKYTV----PPHFVIPKSCSVDRFLDLSRAFCDSRAAFWVYSYG-SSAALVRLAELQPAAQ
.. . .|. ||| |.|..  .|..... .           .|..    |...|.|||.| . . . .| ... |   ..|..  . |.|.|......  .
egwslydilrelkrlglgldlwrisivNe...........nyelcpsYPallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplvgll

QDTKSEN-VMLELVRKC-------------------------------DAGRQLKLLQLtdRLPSIQDVLRAYQKLRRLCTPETPEKfmlqddKYLGLLE
 ..  |.  .|| ..|.                               || .. .|..|   .|.|. | ...|||...|..  ..       ..| |||
lsrsledeklleailkllpnlskllivdlrpklnalanralgggvenedaypnaelifl..nipnihvvreslqklldaclnvpdsl......nllslle

KTNWLFYVSLCLRYASEASATLRSGVT-CVLQESNGRDLCCVISSLAQLLLDPHFRTIDGFQSLVQKEWVALEHPFQRRLGHVYPAQpaggnaelFDSEQ
...|| ...|.|..| ..   |..| . .....|.|.|.....||||||||||..||..|||.|..|||... |.|. ||||..  .         ..| 
esgwldliklilelavlivklldlgnssvlvhcsdgwdrtsqlssLaqllldPyYRTleGFqvLiekeWlsfghkfadRlghlesei........dskef

SPVFLLFLDCVWQLLQQFPDEFEFTQTYLTTLWDSCFMPIFDTFQFDTQAQRLKAvtDSQLVLRPVWDWGEQFSDKdkmfFSNPLYQRQRgdlgaqaaav
|||||||||||||||.||| .|||....|..|.|......|.|| |... .||..  . . .....|..  .....    | ||||..            
sPvFllFLdcvwqLlrqfPtaFeFnerlLlfLadhlyscrfgtFlfnsekerlel..svsertlslwsyllsrkse....flnplYdpss..........

ahrrslavgskgahgaasgvtpsrntinpqlfatassvpqDRYLQPAHRIFDLQVWDQCYYRWLP
                                        . .| | ....||..|...|.||||
........................................levllpslsvldlllWleyylrwlp
subfamily_MTMR10_pd Subfamily MTMR10 278-702 5.5e-179 586.8 In-house 1-380 (380) alignment 
Range on Protein: 278-702
Range on HMM: 1-380/380.0
YATKNDWARELIRCGATEWQVVSCASVQLLQNPLQAGKYTVPPHFVIPKSCSVDRFLDLSRAFCDSRAAFWVYSYGSSAALVRLAELQPAAQQDTKSENV
||.|..|..||.|....|...||.|.|.||.|.|.|...|.|..||.|.|.|.... .|||....||...||.|....|||.||..||.|...|...|..
yaskeawrselerleekekktvsdaivvllknelfaaaqtlPqyfvvpnslsdsdverlsrhykesRfplwvwshakgaallrlsalqeaesadkekeek

MLELVRKCDAGRQLKLLQLTDRLPSIQDVLRAYQKLRRLCTPETPEKFMLQDDKYLGLLEKTNWLFYVSLCLRYASEASATL-RSGVTCVLQESNGRDLC
||||||||......||..|.|.||||||| .||.|||.||...|.|.|. .|||.|..||||.||.||.|||..||.|..|. ... ...||||.||||.
mlelvrkchpandvklvdlsdelpsiqdvqkaylklreLcvidtseefvtlddkwlssLektrWLayvrlclstasdavktvvekkrsvilqesegrDls

CVISSLAQLLLDPHFRTIDGFQSLVQKEWVALEHPFQRRLGHVYPAQPAGGnaelfdseqsPVFLLFLDCVWQLLQQFPDEFEFTQTYLTTLWDSCFMPI
||..|||||.||||.|||.|||||.||||||..|||..||||..|.... .          ||||||||||.|||.|||.|||||.|.|..||||....|
cvvaSLaqlmldphyrtisGfqsliqkewvaaghpfldrlghikpsekses..........pvfllFldcvdqlleqfpseFeFtetfLialwdsshsgi

FDTFQFDTQAQRLKAVTDSQLVLRPVWDWGEQFSDKDKMFFSNPLYQRQRGDLGAQAAAVAHRRSlavgskgahgaasgvtpsrntinpqlfatassvpq
|.||.|....||||||..|...|.......|....||.......||..........|||....||                                   
fltflfnseeqrlkavvsssplliakselkendllkdeldyrqglyaeiiksirrlaaaksylrs...................................

dRYLQPAHRIFDLQVWDQCYYRWLPI
 ....|...|.|.|.||.||.||.|.
.eiirPllqipdiqlWdeCYlRWvPs
Myotub-related Myotubularin-like phosphatase domain 399-590 7.5e-52 169.2 Pfam-A 171-352 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 399-590 7.5e-52 169.2 In-house 171-352 (353) alignment
subfamily_MTMR5_pd Subfamily MTMR5 399-624 1.3e-42 138.2 In-house 234-457 (483) alignment 
Range on Protein: 399-624
Range on HMM: 234-457/483.0
RLPSIQDVLRAYQKLRRLCTPETPEKFMLQDDkYLGLLEKTNWLFYVSLCLRYASEASATLR-SGVTCVLQESNGRDLCCVISSLAQLLLDPHFRTIDGF
.|. |..| ....||.| |.|.|. .   .   .| ..|. .||  .|  |. .. ... |  .|   ..   .|.|.   .||||||||||..||..||
elveirqvkasfkkllraClpstaveeaesqs.FlksvedseWlqqissllqlsgavvdlldlqgssvlvslEdGwdvtaqvsslaqllldpyYRtleGF

QSLVQKEWVALEHPFQRRLGHVYPAQPAggnaelfdsEQSPVFLLFLDCVWQLLQQFPDEFEFTQTYLTTLWDSCFMPIFDTFQFDTQAQRLKAVT----
. ||.|||.|. | |..|  ..  || .           .|||| |||||.|. .||| .||| . ||..|        | || .|.. .||.. .    
kvLveKEWLafGHrFtkrsnqtlsaqss.........gfaPvFlqFLDcvhqvsrqfPlafefndfylkflayhsvsnrfrtfllDseyerlesgllyee

----DSQLVLRPVWDWGEQFSDKDKMFFsNPLYQR
      . . . |||. .. . .  .|. | ||. 
kaekrakkagksvwdyidrqhkrspify.nflysp
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 400-699 7.6e-44 142.5 In-house 164-402 (404) alignment 
Range on Protein: 400-699
Range on HMM: 164-402/404.0
LPSIQDVLRAYQKLRRLCtpetpEKFMLQDDKYLGLLEKTNWLFYVSLCLRYASEASATLR-SGVTCVLQESNGRDLCCVISSLAQLLLDPHFRTIDGFQ
.  |...  ...||. ..     .  . .....|  ||...||  ..| |. . ... ..  ..  .... |.| |  . .|||.||||||..||| ||.
ienihelreslkklkkav.....nsiiekeknwlselessrWldhiklllegskriveliekekssvlvhcsdgwDrtsqlsslsqllldpyyrtiegFi

SLVQKEWVALEHPFQRRLGHvypaqpaggNAELFDSEQSPVFLLFLDCVWQLLQQFPDEFEFTQTYLTTLWDSCFMPIFDTFQFDTQAQRLKAVTDSQLV
.|..|||. . | |..| |.         . |  ..|.||.|| |.|||.||..|||..||| . .|... |.     | || .|.. .| .. . ...|
vliekewlsfGhkfaqRigq.........ttekssdersPiflqFidcvyqltkqfptsFeFnekflikildalyscrfgtFLydsekeRqqnnlaketv

lrPVWDwgeqFSDKDKMFFSNPLYQRQRGDLGAQAAAVA----HrrslavgskgahgaasgvtpsrntinpqlfatassvpqdrylqpahRIFDLQVWDQ
   .|       ...|  . ||||. .. .   .         .                                               |  ...|..
..slWa....lleankseylnplyilekkeqkenitssessssa..............................................dikliklWse

CYYRW
 | ||
yylrw
subfamily_MTMR3_pd Subfamily MTMR3 400-628 1.3e-41 135.8 In-house 212-421 (442) alignment 
Range on Protein: 400-628
Range on HMM: 212-421/442.0
LPSIQDVLRAYQKLRRLCTpETPEkfmlqDDKYLGLLEKTNWLFYVSLCLRYASEASATLRS-GVTCVLQESNGRDLCCVISSLAQLLLDPHFRTIDGFQ
|. |  | .....|| |.. ..|.     . ..|. ||||.||  .|  |. | . . ..   | . ..  |.| |    | .||.|||||..||..||.
lanihavrksfnslralls.qspd.....esnwlsalektkWlqnlsvllkaavkvveavdkegrpvlvhCsdGWdrttqivalakllldpyyrtleGfk

SLVQKEWVALEHPFQRRLGHvypaqpaGGNAELfDSEQSPVFLLFLDCVWQLLQQFPDEFEFTQTYLTTLWDSCFMPIFDTFQFDTQAQRLKAVTDSQLV
 ||..||... | |. | ||       | | .    |..|||| .||.| || .|||  |||....|  |   ..  .| || .... .| .  . ....
vlvereWldfGhkfadrcgh.......genvdd.anercPvflqwldavhqlqrqfPtsfefneaflvklvqhtysclfGtflansekereeekvkertl

lrPVWDWgeqFSDKDKMfFSNPLYQRQRGD
   ||..   .  |.|. . | ||...   
..svWsl...lrakeke.yrnllykektea
subfamily_MTMR1_pd Subfamily MTMR1 401-625 9.1e-50 162.0 In-house 156-361 (389) alignment 
Range on Protein: 401-625
Range on HMM: 156-361/389.0
PSIQDVLRAYQKLRRLCTPETpekfmlQDDKYLGLLEKTNWLFYVSLCLRYASEASATLRSGVTC-VLQESNGRDLCCVISSLAQLLLDPHFRTIDGFQS
..|. |  ...||. |. |..      .|.|.|  ||.|.|| ...| |. | .   .. .  |  ..  |.| |    . |||.||||...|||.||. 
hnihvvReslkklkelvlpnv......ddkkwlsalestkWlehiklilagavkivekvetektsvlvhcsdGWDRtaqltsLamlllDsyyRtieGfev

LVQKEWVALEHPFQRRLGHvypaqpagGNAELFDSEQSPVFLLFLDCVWQLLQQFPDEFEFTQTYLTTLWDSCFMPIFDTFQFDTQAQRLKAVTDSQLVl
|..|||..  |.|..||||        |...  |.|.||||| |.|||||| .|||  |||....| || |     .| ||.|.....| |.  ... | 
liekeWlsfGHkfkeRlgh........gdknssdaersPvFlqfiDcvwqltrqfptAFefneefLitlldhlysclfGtflfnsekervkekvkektv.

rPVWDWgeqfSDKDKMFFSNPLYQRQ
 ..| .     ...|. |.||||...
.slwsy....vnsskeeftnplyaee
subfamily_MTMR9_pd Subfamily MTMR9 402-627 2.4e-46 150.5 In-house 158-371 (393) alignment 
Range on Protein: 402-627
Range on HMM: 158-371/393.0
SIQDVLRAYQKLRRLCtpETPEKFMLQDDKYLGLLEKTNWLFYVSLCLRYASEASATLRS-GVTCVLQESNGRDLCCVISSLAQLLLDPHFRTIDGFQSL
|.. |    . |..|   |. ..  |. ||.|  |||..||  |   |. |  .. .| . |.. |.....| |  ....|||||.|||..||..||..|
slesvasiqdslakll..eacsdaglstdkflsrleksgwlsqvadlleaalvvaqcldeegapvvvhgeeGlDatlqvtsLaqlildpdaRtvrgfeal

VQKEWVALEHPFQRRLGHVYPAQpaggnaeLFDSEQSPVFLLFLDCVWQLLQQFPDEFEFTQTYLTTLWDSCFMPIFDTFQFDTQAQRLKAVTDSQLvlR
...||.   |||. |  .|  ..         . ...||||||||||.|.|.||| .||| ...|..|.   ..  | ||  |..|.| ..  ...   .
iereWiqaGHPFasRaskvaake.......tkkklsgpvfllFLDcvyqilsqfpasFEFneelLillfehsyssqfgtflcdneaerkelklkkkt..v

PVWDWGEQFSDKDKmfFSNPLYQRQRG
 .|.. .. .  ..  | ||||.... 
slwsyvnrpeklkq..flnplyeanae
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 428-623 1.7e-31 101.4 In-house 199-378 (405) alignment 
Range on Protein: 428-623
Range on HMM: 199-378/405.0
QDDKYLGLLEKTNWLFYVSLCLRYASEASATLRSGVTCVLQESNGRDLCCVISSLAQLLLDPHFRTIDGFQSLVQKEWVALEHPFQRRLGHVypaqPagG
 | .. | .|.| |. ..   |  |. ..  .  | . ... |.| |    |.||.|.||||..||| ||| |..|||... | |  ||||.    |  |
tdmrfwgyieetgwishiksileaatfsaelilkgnsilvhcsdgwdrtpqitsltqilldpyyrtivgfqvliekewlsfghkfslrlghl....p..g

NAElfdsEQSPVFLLFLDCVWQLLQQFPDEFEFTQTYLTTLWDSCFMPIFDTFQFDTQAQRLKavtdSQLVLRPVWDWGEQFSDKDKmfFSNPLYQ
| |    |.||.|  ||||..|||.|||  |||| . |  . |      . ||  . . .|..     |. .. .  | |   . .|  | || |.
nee....erspifqqfldccfqllsqfpllfeftpslllfisdnihsckygtflnncekdrvq....dqvktktisiwsevnlnvnk..flnpyyn
subfamily_MTMR6_pd Subfamily MTMR6 430-626 3.7e-36 117.3 In-house 190-371 (397) alignment 
Range on Protein: 430-626
Range on HMM: 190-371/397.0
DKYLGLLEKTNWLFYVSLCLRYASEASATL-RSGVTCVLQESNGRDLCCVISSLAQLLLDPHFRTIDGFQSLVQKEWVALEHPFQRRLGHVypaqpaggn
 ..|  ||...|| ..   |  .   . .. ..|.....  |.| |  . . |||.|||||..|||.||. |..|||... | |..| |..         
seflsglessgwlkhikavldasifiakavaeegasvlvhcsdGwdrtaqvcslasllldpyyrtikGflvliekewlsfGhkfsercGll.........

aELFDSEQSPVFLLFLDCVWQLLQQFPDEFEFTQTYLTTLWDSCFMPIFDTFQFDTQAQRLkavtDSQLVLRPVWDWGeqFSDKDKMFFSNPLYQRQR
 .    | ||.|. ||.||||||.|||  ||| ...| .| |  .   | ||  ... .|     | .|  |    |.  .  ..|  . ||||. ..
.dedskevsPiftqflecvwqlleqfpkafefnerfllelhdhvyscqfGtflgncekdrr....dlklkertkslwa..yllerkddylnplykaet
subfamily_pats1_pd Subfamily pats1 436-518 4.9e-14 43.6 In-house 373-459 (691) alignment 
Range on Protein: 436-518
Range on HMM: 373-459/691.0
LEKTNWLFYVSLCLRYASEASATLRSGVTCVLQESNGR---DLCC-VISSLAQLLLDPHFRTIDGFQSLVQKEWVALEHPFQRRLGH
.|.  |.  | | |  | . |  |  | . .|..|      .|    ||||||.|.||..||.|||. |..|||.   .||...  |
ieeskwvdsvkllleaavkvsnlldeGssvllknsidsPlieldlasisslaqvlsdPfyrtldGfkvliekewlsyGfPfskinyh
subfamily_pats1_pd Subfamily pats1 532-623 3.2e-11 34.3 In-house 548-633 (691) alignment 
Range on Protein: 532-623
Range on HMM: 548-633/691.0
FDSEQSPVFLLFLDCVWQLLQQFPDEFEFTQTYLTTLWDSCFMPIFDTFQFDTQAQRLKAVTDSQlvLRPVWdwgeQFSDKDKMFFSNPLYQ
 .   ||.|. ||| |||| ..||  ||| . .| .| .  |   | .| ..   ..      ..   . .|     | ...|  | | ||.
vnrsfsPifvqfldlvwqlqkefPfhfefneslllllvkesfssrfGnflyseakrdserkvlkr..sksiw....sfinqnksrfinllyk
3-PAP Myotubularin-associated protein 650-745 6e-36 113.8 Pfam-A 31-142 (142) alignment 
Range on Protein: 650-745
Range on HMM: 31-142/142.0
HGAA--------------SGVTPSRNTINPQLFATASSVP--QDRYLQPAHRIFDLQVWDQCYYRWLPILDIRGGGQPQVDLYHRLLLSNIAKVQRCLDY
.                 |  .||..|...||..||||||  ....|.| ... ||..|.|||.||.| ..|.||||.|||| ...||..|||.||.|. 
eapdllllkllisllsdcsvsspspataseqlsktassvPadlhqlLlpqqlgldlslWsqcylRwiPeaeikgggqvqvdlklselleeiaklqrlleq

QNFDDLPDAYYE
....|||.|..|
rdmsdlpeanle