Gene CG5026 in Drosophila melanogaster

Synonym: Dmel\CG5026, Dmel_CG5026, CG5026

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR9
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP033_AA protein Get Run
DmelP033_AA_201-572 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Myotub-related Myotubularin-like phosphatase domain 117-514 2e-124 407.9 Pfam-A 2-352 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 117-514 2e-124 407.9 In-house 2-352 (353) alignment
subfamily_MTMR9_pd Subfamily MTMR9 119-568 2.5e-190 624.6 In-house 1-392 (393) alignment 
Range on Protein: 119-568
Range on HMM: 1-392/393.0
PFFYRPMYSILEDGYTMFRPELEFAKLISgvgmggasspnvaniticmpstststltvgagiphplqngyaiealacgvggvgggalqspqASCEWRITN
|||||....||||||..|..|.|||||||                                                              ||.||||..
pffyrsvatiledgysafdrenefaklis..............................................................asdewRiss

VNRDFSVCATYGATLIVPKAITDEQIVLSAAFRDGGRFPVLSYRH-ENGATLMRSSQPLSIQGIKRCRADEAILNLVLGRSRKGFIVDTWGKGKSNT---
||..|.|||.|....||||||.||....|||||.|||||||||.| |..|.|.||||||... .|||..||..|||||....||.||||..| ....   
vNknfkvcasypesvivPkaiddeelkasaafreggrfPvLsylhketkavllrssqplcgssgkrckedekllnlvlkklkkGlivdtrsksaaenars

-----ETDLHYSQWKKVNRSIgnvSSPASILDSFARLIEACNDLGCSTDKWLSRLENSGWLSLVLNSLNASCVVAQCLDQEGSPVLVHGAKGLDSTLIVT
     ||. .||||||..||.   .|.||| ||.|.|.|||.|.|.||||.|||||.||||| | ..|.|..|||||||.||.||.|||..|||.||.||
kgggietevkysqwkkasrsl...esvasiqdslaklleacsdaglstdkflsrleksgwlsqvadlleaalvvaqcldeegapvvvhgeeGlDatlqvt

SLVQIILNPDCRTVRGLQALIEREWIQAGHPFASRHRYSCYTPnqTRNKTSGATFVLFLDCIYQLYTQFPCSFEFSTQLLILLFEHSHFSQYGTFLCDSE
||.|.||.||.|||||..|||||||||||||||||........  |..|.||..|.|||||.||...|||.||||...|||||||||..||.||||||.|
sLaqlildpdaRtvrgfealiereWiqaGHPFasRaskvaake..tkkklsgpvfllFLDcvyqilsqfpasFEFneelLillfehsyssqfgtflcdne

RERNELNVHTRTTSLWSYLNRPDVLQTFLNPLYEPNANVIWPSVAPISLELWSDLYLRW
.||.||.....|.|||||.|||..|..|||||||.||.||||||||.||||||.|||||
aerkelklkkktvslwsyvnrpeklkqflnplyeanaeviwpsvapqslelWselylrw
subfamily_MTMR5_pd Subfamily MTMR5 202-285 1.7e-17 55.4 In-house 19-103 (483) alignment 
Range on Protein: 202-285
Range on HMM: 19-103/483.0
GGALQSPQASCEWRITNVNRDFSVCATYGATLIVPKAITDEQIVLSAAFRDGGRFPVLSYRHE-NGATLMRSSQPLSIQGIKRCR
 |||.. ... ..||..||....|| .| | ..||... |..|   |     .|.||  .||| |.|.|.||... |.. ..  .
lgalngaskrgkfrisevNkkytvcrsYPalivvPsevsddsiarvakcfrqnRlPvvtWrhernkalLiRsggfeskgvvgllk
subfamily_MTMR10_pd Subfamily MTMR10 206-569 2.8e-59 192.8 In-house 18-378 (380) alignment 
Range on Protein: 206-569
Range on HMM: 18-378/380.0
QSPQASCEWRITNVNRDFSVCATYGATLIVPKAITDEQIV-LSAAFRDgGRFPVLSYRHENGATLMRSSQPLSIQGIKrcRADEAILNLVLGRSRKGFiv
.  ..|.... ...|  | .. |.   ..||. ..|...  || .... .|||.... | .||.|.| |.    . ..   ..|.  .. . ..  .   
ekktvsdaivvllknelfaaaqtlPqyfvvpnslsdsdverlsrhyke.sRfplwvwshakgaallrlsalqeaesad..kekeekmlelvrkchpan..

dtwgkgksntetDLHYSQWKKVNRSIGNVSSPASILDSFArLIEACNDLGCSTDKWLSRLENSGWLSLVLNSLNASCVVAQCLDQEGSPVLVHGAKGLDS
            |... . ..   || .|..  . | .   .|. ....    ||||| ||...|| .|  .|. .  ..... ... .|..  ..| | 
............dvklvdlsdelpsiqdvqkaylklreLc.vidtseefvtlddkwlssLektrWLayvrlclstasdavktvvekkrsvilqesegrDl

TLIVTSLVQIILNPDCRTVRGLQALIEREWIQAGHPFASRhRYSCYtPNQTRNKtsgATFVLFLDCIYQLYTQFPCSFEFSTQLLILLFEHSHFSQYGTF
 ..| ||.|..| | .|| .|.| ||..||. ||||| .|    .. |......    .|.||||| .|| .||| .|||. ..|| |. .|| . ..||
scvvaSLaqlmldphyrtisGfqsliqkewvaaghpfldr.lghik.psekses...pvfllFldcvdqlleqfpseFeFtetfLialwdsshsgifltf

LCDSERERNEL----NVHTRTTSLWSYLNRPDVLQTFLNPLYEPN---------------ANVIWPSVAPISLELWSDLYLRWV
|..||..| .     .. ... | . . .  .    . ..||                  ...| |    . ..||.. |||||
lfnseeqrlkavvsssplliakselkendllkdeldyrqglyaeiiksirrlaaaksylrseiirPllqipdiqlWdeCYlRWv
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 209-567 8.7e-58 188.0 In-house 37-403 (405) alignment 
Range on Protein: 209-567
Range on HMM: 37-403/405.0
QASCEWRITNVNRDFSVCATYGATLIVPKAITDEQIVLSAAFRDGGRFPVLSYRHEN-GATLMRSSQPLSIQGIKRCRADEAI-LNLVLGR-SRKGFIVD
...| |..|..|... .|..| ..|.| .  .| ..    .||  || | ||..  .  |.. | ||||      ||  ||    .| |   |.  ...|
ssncywkvtsinkeykmcssyssslvvlskaldkdlekifsfrskgripslswkdpssnasisrcsqplvgierarcpedelycsslalsapsktlylid

TWGKGKSNTET-------DL-HYSQWKKVNRSIGNVSSPASILDSFARLIEA---CNDLGCSTD-KWLSRLENSGWLSLVLNSLNASCVVAQCLdQEGSP
.  | .. ..|       ..  | . | |   | |.      |. ..  ...    .|   ||| ..   .|..||.| .   |.|. . |. .   |  
arpklnaiantangagfenihnypncklvfmnipnihvirksleklvlamkssardkdhtestdmrfwgyieetgwishiksileaatfsaeli.lkgns

VLVHGAKGLDSTLIVTSLVQIILNPDCRTVRGLQALIEREWIQAGHPFASRHRYscyTPNQTRNKtsGATFVLFLDCIYQLYTQFPCSFEFSTQLLILLF
.||| . | | |  .||| ||.|.|  ||. |.| |||.||.  || |. |  .    | .  ..     |  |||| .|| .|||  |||.  ||... 
ilvhcsdgwdrtpqitsltqilldpyyrtivgfqvliekewlsfghkfslrlgh...lpgneeer..spifqqfldccfqllsqfpllfeftpslllfis

EHSHFSQYGTFLCDSERERNELNVHTRTTSLWSYLNRpdVLQTFLNPLYEPN-ANVIWPSVAPISLELWSDLYLR
.  |  .||||| . |..| . .|.|.|.|.|| .|    .. |||| |.|.  . | | .    ||||   |.|
dnihsckygtflnncekdrvqdqvktktisiwsevnl..nvnkflnpyynpqdiqsikpklysrclelwkacymr
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 210-568 6.7e-86 281.0 In-house 32-402 (404) alignment 
Range on Protein: 210-568
Range on HMM: 32-402/404.0
ASCEWRITNVNRDFSVCATYGATLIVPKAITDEQIVLSAAFRDGGRFPVLSYRHE-NGATLMRSSQPLSIQGIKRCRADEAILNLVLG---RSRKGFIVD
.. ||||...| |...| ||  .|.||. |.||... .|.||. ||.||||.||. ...|..||||||   . .|.  || ..| .      ... .|.|
seseWriskinsdyelcetYPkllvvPesisDeelkkvasfRskgRiPvlswrhrsknstitRssqplvGltksrseedEklinsirkaktqletlyild

TWG--KGKSNTETDLHYSQ---WKKVNRSIGNVSSPASILDSFARLIEACNDLGCSTDKWLSRLENSGWLSLVLNSLNASCVVAQCLDQEGSPVLVHGAK
.    . ..|...  .|..    .... .  |..   .. .|. .| .|.|.   ....|||.||.|.||  . . |..|  ... ...|.|.||||   
arpkanavansakgagyedisryenceieflnienihelreslkklkkavnsiiekeknwlselessrWldhiklllegskriveliekekssvlvhcsd

GLDSTLIVTSLVQIILNPDCRTVRGLQALIEREWIQAGHPFASRHRYscytPNQTRNKTSGATFVLFLDCIYQLYTQFPCSFEFSTQLLILLFEHSHFSQ
|.| |  ..||.|..|.|  ||..| . |||.||.. || ||.|...     ......     |. |.||.|||  ||| ||||. ..|| . ...  ..
gwDrtsqlsslsqllldpyyrtiegFivliekewlsfGhkfaqRigq....ttekssdersPiflqFidcvyqltkqfptsFeFnekflikildalyscr

YGTFLCDSERERNELNVHTRTTSLWSYLNRPDvlQTFLNPLY----EPNANVIWPSV-----APISLELWSDLYLRW
.||||.|||.||.. |... |.|||..|.     ...|||||    . . . |  |       .  ..|||..||||
fgtFLydsekeRqqnnlaketvslWalleank..seylnplyilekkeqkenitssessssadikliklWseyylrw
0040695 (Phosphotyrosine protein) phosphatases II 212-568 1.7e-112 369.8 In-house 25-385 (388) alignment 
Range on Protein: 212-568
Range on HMM: 25-385/388.0
CEWRITNVNRDFSVCATYGATLIVPKAITDEQIVLSAAFRDGGRFPVLSYRHE-NGATLMRSSQPLSIQGIKRCRADEAILNLVLG---RSRKGFIVDTW
..|||..||.....| .| | |.||| |.||... .| ||..||.|||||||  |||.|.||||||. . ..|. .|| .|. .|.   ...|..|||..
dlwrisivNenyelcpsYPallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplvglllsrsledeklleailkllpnlskllivdlr

GKG--------KSNTETDLHYSQWKKVNRSIGNVSspaSILDSFARLIEACnDLGCSTDKWLSRLENSGWLSLVLNSLNASCVVAQCLDQEGSPVLVHGA
.|         ....|   .|......  .| |..    . .|. .|..|| .  ......||.||.||||.|. . |.........||...|.||||. 
pklnalanralgggvenedaypnaeliflnipnih...vvreslqklldac.lnvpdslnllslleesgwldliklilelavlivklldlgnssvlvhcs

KGLDSTLIVTSLVQIILNPDCRTVRGLQALIEREWIQAGHPFASRHRYscyTPNQTRNKTSGATFVLFLDCIYQLYTQFPCSFEFSTQLLILLFEHSHFS
.| |.| ...||.|..|.|..||..|.| |||.||...||.||.|. .   .......|    .|.|||||..||. |||..|||. .||..|..|.. .
dgwdrtsqlssLaqllldPyYRTleGFqvLiekeWlsfghkfadRlgh...leseidskefsPvFllFLdcvwqLlrqfPtaFeFnerlLlfLadhlysc

QYGTFLCDSERERNELNVHTRTTSLWSYLNRPDVLqtFLNPLYEPNAN-VIWPSVAPISLELWSDLYLRW
..||||..||.|| ||.|..|| ||||||....    ||||||.|. . |..||. ...| ||...||||
rfgtFlfnsekerlelsvsertlslwsyllsrkse..flnplYdpsslevllpslsvldlllWleyylrw
subfamily_MTMR6_pd Subfamily MTMR6 212-568 2.9e-82 269.0 In-house 36-395 (397) alignment 
Range on Protein: 212-568
Range on HMM: 36-395/397.0
CEWRITNVNRDFSVCATYGATLIVPKAITDEQIVLSAAFRDGGRFPVLSYRH-ENGATLMRSSQPLSIQGIkRCRADEAILNLVLG---RSRKGFIVDTW
 .| .|..|.|...| ||. .| |||..| |..| |. ||  ||.||||| | || |.. |.|||||     ||  ||..|...     .|.  ..||| 
ekwtltdlnkdyelcdtyprelyvPksatkevlvgsskfrskgrlPvlsylhkeneaaicrcsqplsgfsa.rcledeklleairkanpnsellyvvdtr

GKGK--SNTETDLHYS---QWKKVNRSIGNVSSPASILDSFARLIEACNDLGCSTDKWLSRLENSGWLSLVLNSLNASCVVAQCLDQEGSPVLVHGAKGL
 |    .|  ..  |    ... ..    ..     . .| ..|.|...    |. ..|| ||.||||  . . |.||...|. . .||  |||| . | 
pklnalankaagkGyenednysnikfqfvgienihvmreslqkllevvelksksvseflsglessgwlkhikavldasifiakavaeegasvlvhcsdGw

DSTLIVTSLVQIILNPDCRTVRGLQALIEREWIQAGHPFASRHRYScytpnQTRNKTSGATFVLFLDCIYQLYTQFPCSFEFSTQLLILLFEHSHFSQYG
| |  |.|| ...|.|  ||..|.. |||.||.  || | .|  .      .. .|     |  ||.|..|| .|||..|||. . |. | .| . .|.|
drtaqvcslasllldpyyrtikGflvliekewlsfGhkfsercGll.....dedskevsPiftqflecvwqlleqfpkafefnerfllelhdhvyscqfG

TFLCDSERERNELNVHTRTTSLWSYLNRpdVLQTFLNPLYEPNAN--VIWPSVAPISLELWSDLYLRW
|||...|..|..|... ||.|||.|| .    . .|||||.....  |..|..|| .|.||. || |.
tflgncekdrrdlklkertkslwaylle..rkddylnplykaetekevlkpdtapaalklwralynrf
subfamily_MTMR3_pd Subfamily MTMR3 212-295 2e-21 69.3 In-house 42-126 (442) alignment 
Range on Protein: 212-295
Range on HMM: 42-126/442.0
CEWRITNVNRDFSVCATYGATLIVPKAITDEQIVLSAAFRDGGRFPVLSYRHE-NGATLMRSSQPLSIQGIKRCRADEAILNLVL
 .|||..|| || .|..|  .||||| |||...  .| ||  .|.|.. .||. ||| |.|.|||       |.. || .|. . 
eawrisdvnsdfklCssyPkklivPksitdddlkkvasfrslkrlPavvwrhkkngavlarcsqPevgwlgWrnaedekllkaia
subfamily_MTMR1_pd Subfamily MTMR1 213-568 2.8e-84 275.7 In-house 26-386 (389) alignment 
Range on Protein: 213-568
Range on HMM: 26-386/389.0
EWRITNVNRDFSVCATYGATLIVPKAITDEQIVLSAAFRDGGRFPVLSYRHE-NGATLMRSSQPLSIQGIKRCRADEAILNLVLGRSR---KGFIVDTWG
 ||||..|.....| || |.|.|||...||..  .||||. ||.||||. .. |.|...|.||||.    ||.. ||..|. .|       | .|.|   
lWritklnkkyelcdtYpavlvvpkvvsdedlkkvaafrskgRlPvlswlnkenqavilrasqplvGlsgkrskedekylqaileanaqsekllildars

KGK--SNTETDL---HYSQWKKVNRSIGNVSSPASILDSFARLIEACNDlGCSTDKWLSRLENSGWLSLVLNSLNASCVVAQCLDQEGSPVLVHGAKGLD
. .  .|  .     . ...|...    ....  .. .|. .| |..     . .|||| ||.. ||. .   |...  .......| . ||||  .| |
svnavankakgkgyeseeaYknaelifldihnihvvReslkklkelvlp.nvddkkwlsalestkWlehiklilagavkivekvetektsvlvhcsdGWD

STLIVTSLVQIILNPDCRTVRGLQALIEREWIQAGHPFASRHRYscyTPNQTRNKTSGATFVLFLDCIYQLYTQFPCSFEFSTQLLILLFEHSHFSQYGT
 |  .||| ...|..  ||..|.. |||.||.. ||.|..|.     . ... ..  .  |. |.||..||  |||. |||  ..|| | .|.. . .||
RtaqltsLamlllDsyyRtieGfevliekeWlsfGHkfkeRlgh...gdknssdaersPvFlqfiDcvwqltrqfptAFefneefLitlldhlysclfGt

FLCDSERERNELNVHTRTTSLWSYLNRpdVLQTFLNPLYEPN--ANVIWPSVAPISLELWSDLYLRW
||..||.|| . .|...|.|||||.|     ..| ||||...   .|. | ..  .||||.. ||||
flfnsekervkekvkektvslwsyvns..skeeftnplyaeelekkvlypkaslrrlelWkeyylrw
subfamily_pats1_pd Subfamily pats1 213-267 1.7e-06 18.7 In-house 25-77 (691) alignment 
Range on Protein: 213-267
Range on HMM: 25-77/691.0
EWRITN-VNRDfsVCATYGATLIVPKAITDEqIVLSAAFRDGGRFPVLSYRHENGA
.||... ..||  ..  |  . .||| ..|| .. | . .   ..||||. ..|  
dwrvveflsrd..lseiyPkrilvPklvsde.llvsyvrkrsskiPvlswsnqnnk
subfamily_MTMR3_pd Subfamily MTMR3 319-567 1.5e-57 188.4 In-house 201-441 (442) alignment 
Range on Protein: 319-567
Range on HMM: 201-441/442.0
HYSQWKKVNRSIGNVSspaSILDSFARLIEACNdLGCSTDKWLSRLENSGWLSLVLNSLNASCVVAQCLDQEGSPVLVHGAKGLDSTLIVTSLVQIILNP
.|.. . |  ...|.    ..  ||  | . ..  .  . .|||.||.  ||  . . |.|.  |.. .|.|| ||||| . | | |  ...| ...|.|
yypncevvflglanih...avrksfnslralls.qspdesnwlsalektkWlqnlsvllkaavkvveavdkegrpvlvhCsdGWdrttqivalakllldp

DCRTVRGLQALIEREWIQAGHPFASRhrySCYTPNQTRNKTSGATFVLFLDCIYQLYTQFPCSFEFSTQLLILLFEHSHFSQYGTFLCDSERERNELNVH
  ||..|...|.||||.. || || |   . . .|.  ..     |. .||...||  |||.||||..  |. | .|.. . .||||..||.||.| .|.
yyrtleGfkvlvereWldfGhkfadr...cghgenvddanercPvflqwldavhqlqrqfPtsfefneaflvklvqhtysclfGtflansekereeekvk

TRTTSLWSYLNRPDvlQTFLNPLYEP-NANVIWPSVAPISLELWSDLYLR
.|| |.||.|.  .  ... | ||.. . .|..|.|  ..|.|||..|| 
ertlsvWsllrake..keyrnllykekteavllpavsvrelklwsevyle
subfamily_pats1_pd Subfamily pats1 332-446 2.3e-17 54.6 In-house 342-458 (691) alignment 
Range on Protein: 332-446
Range on HMM: 342-458/691.0
NVSSPASILDSFARLIEACNDLGCSTDKWlSRLENSGWLSLVLNSLNASCVVAQCLDQEGSPVLVHGAKGLDSTLIV---TSLVQIILNPDCRTVRGLQA
.. ..  . . | .|...  .|. | |.| . .|.| |.  |   |.|.  |.. ||.  | .|    .. . .| .   .|| |....|  ||. |.. 
slPtrekveerffdllqsilsldgsddew.keieeskwvdsvkllleaavkvsnlldeGssvllknsidsPlieldlasisslaqvlsdPfyrtldGfkv

LIEREWIQAGHPFASRHR
|||.||.. |.||. .  
liekewlsyGfPfskiny
subfamily_MTMR5_pd Subfamily MTMR5 339-562 2.3e-44 144.0 In-house 241-476 (483) alignment 
Range on Protein: 339-562
Range on HMM: 241-476/483.0
ILDSFARLIEACNDLGCSTDK----WLSRLENSGWLSLVLNSLNASCVVAQCLDQEGSPVLVHGAKGLDSTLIVTSLVQIILNPDCRTVRGLQALIEREW
.  || .|. ||     ....    .|. .|.| ||. . . |. | .|.. || .|| |||   .| | | .|.||.|..|.|  ||. | ..|.|.||
vkasfkkllraClpstaveeaesqsFlksvedseWlqqissllqlsgavvdlldlqgssvlvslEdGwdvtaqvsslaqllldpyYRtleGFkvLveKEW

IQAGHPFASRhrySCYTPNQtRNKTSGATFVLFLDCIYQLYTQFPCSFEFSTQLLILLFEHSHFSQYGTFLCDSERERNELNV----------HTRTTSL
.  || |. |   |. |...  . ..  .|. ||||..|. .||| .|||..  | .|  ||   .. ||| ||| || | ..          .. ..|.
LafGHrFtkr...snqtlsa.qssgfaPvFlqFLDcvhqvsrqfPlafefndfylkflayhsvsnrfrtfllDseyerlesgllyeekaekrakkagksv

WSYLNRPD-VLQTFLNPLYEP-NANVIWPSVAPISLELWS
| |..| . .   | | ||.| ...|. ||.   ||..|.
wdyidrqhkrspifynflyspdesevlrPssnvsslkvWd
subfamily_pats1_pd Subfamily pats1 457-548 1.4e-19 61.9 In-house 549-638 (691) alignment 
Range on Protein: 457-548
Range on HMM: 549-638/691.0
NKTSGATFVLFLDCIYQLYTQFPCSFEFSTQLLILLFEHSHFSQYGTFLCDSERERNELNVHTRTTSLWSYLNRPDvlQTFLNPLYEPNANV
|..    || ||| ..||. .||  |||  .||.|| ..|. |..|.||..  ... | .|  |. |.||. |.     .|.| || . |. 
nrsfsPifvqfldlvwqlqkefPfhfefneslllllvkesfssrfGnflyseakrdserkvlkrsksiwsfinqnk..srfinllykhsass