Gene CG42327 in Drosophila melanogaster

Synonym: CG14713, CG14714, CG18479, Dmel\CG42327, Dmel_CG14713, Dmel_CG14714, anon-WO0118547.710, Dmel_CG42327, CG42327

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CG42327
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP036_AA protein Get Run
DmelP036_AA_1104-1420 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
TMEM154 TMEM154 protein family 955-1043 6.1e-06 17.6 Pfam-A 5-91 (146) alignment 
Range on Protein: 955-1043
Range on HMM: 5-91/146.0
STVASTTIRSST-----TmlPETTTASTQSPSempptfmaPYPNELDHM---QTNAQDNgtDVNVIIAITVSVIGVVALILLVAFLYLM--RKRQKQTS
.... ... . |     .  . .|.||...|.        . .  ..     .......  ...... | .  .  . |.|.|..|  .  |||.||  
eesteeklevetlekatv..tastlasvtdpe........tlsanvnleegelseksad..qaelvlmiiiPsvvLillllvvvilvikkkrkrrKqee
DUF4448 Protein of unknown function (DUF4448) 983-1040 2.9e-06 15.6 Pfam-A 123-187 (189) alignment 
Range on Protein: 983-1040
Range on HMM: 123-187/189.0
MPPTFMAPYPNELDHMQ-------TNAQDNGTDVNVIIAITVSVIGVVALILLVAFLYLMRKRQK
. ||... .. .|.. .        .....|.|  ...||...|. |||......||...||...
kGptVsltskkdlkkkeksekasnnkseeegsdekyalaialPvvvvvaalgvllfllinrkkrr
SKG6 Transmembrane alpha-helix domain 1010-1040 9.6e-06 15.0 Pfam-A 10-40 (40) alignment 
Range on Protein: 1010-1040
Range on HMM: 10-40/40.0
NVIIAITVsVIGVVALILLV-AFLYLMRKRQK
.| ||. | ||.|....|.. .||.| ..|.|
tvaIavgV.viPVgvIalvLlvfLilvyRRkk
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1099-1291 2.5e-26 87.5 In-house 13-204 (297) alignment 
Range on Protein: 1099-1291
Range on HMM: 13-204/297.0
SELARFVE--RRSDVF-EEFRDVPQIIARADEVPPGC--EDKNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGPRDapnYYIACQAPLESTTSDFW
|..| .|.  |..||| |||...|.   ... |       .|.||.|..|    || |.  .|| . .|.|| .|.| .     .|. | | ..|  |||
sdfatlvqknrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfW

RMIWEQQSRVIIQATDLSENGIeRCAEYLPPSATLDnhssYGDYQVTLKHREVKDRYAISTLVLKRVDGEESRELTHYWY-KWPEAGVPA-EEAPIIAML
.|....|  .|.  .|..|.   .|| | . ...      .||  |.|.  . .  .   .|.... .    | .  | . .||.  |.  ..|. .  |
amvldeqvstivmlnddnerdk.kcaryWsdkgvtt....fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllkl
subfamily_egg_pd Subfamily egg 1101-1275 1.8e-14 48.1 In-house 12-181 (307) alignment 
Range on Protein: 1101-1275
Range on HMM: 12-181/307.0
LARFVERRSDVFEEFRDVPQIIARADEvppGCEDKNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGpRDAPNYYIACQAPLESTTSDFWRMIWEQQ
.   .|||  | ||  |   .   |..      .| |   |     .|| |. .      ..| ||.|.| .   | .| .||||  |  |||||.....
ivqelerrlevleesvdeislttaasd...nnlekarskrvhckdssrvklelrrGqylddfihanrvkG.kpllnefilaqaplkntvddfwrmvfqee

SRVIIQATDLSENgiERCAEYLPPSATLDNHSSYGDYQVTLKHRE-VKD-RYAISTLVLkrVDG-EESRELTHYWYKW
 . |.  |   |.  |||  | | . .       | ....  . .   |  . .. | |  | | .| | | |. . .
vqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklkl..vGgddeerflehwqgdv
subfamily_CG42327_pd Subfamily CG42327 1105-1423 1.3e-195 643.3 In-house 1-319 (319) alignment 
Range on Protein: 1105-1423
Range on HMM: 1-319/319.0
VERRSDVFEEFRDVPQIIARADEVPPGCEDKNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGPRDAPNYYIACQAPLESTTSDFWRMIWEQQSRVI
||||.||.|||||.||.||||||||....||.|..||.|||||||||||.|||||.||..|.||||..||||.|||.|..||...|||||..||||||||
verredvaeefrdlPqliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvi

IQATDLSENGIERCAEYLPPSATLDNHSSYGDYQVTLKHREVKDRYAISTLVLKRVDGEESRELTHYWYKWPEAGVPAEEAPIIAMLLEARSSLKSYSLE
.|.|||||.||..||||||...||||.|.|||..||||.||||||||||||.|||||.|||||||||||||.||.||||||..||||||.||||||||||
vqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywykwleaevPaeeaaliamllevrsslksysle

QANELREKSATLETSMDADGSKAEAGSTSSHEINGNISSRSGTRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETPKRSVDIPQLVYYVRRGRASAVQT
||||||||||||||||||||||||||||||||||||||||||||..||||.||||.|.||||..||||.||||||..||||||||||..|||.|||||.|
qanelreksatletsmdadgskaeagstssheingnissrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavlt

KEQYEFIYKVASMYAAKIT
||||||||||.|.||.|.|
keqyefiykvlseyakklt
0051299 (Phosphotyrosine protein) phosphatases II 1105-1419 9.9e-72 237.1 In-house 22-286 (288) alignment 
Range on Protein: 1105-1419
Range on HMM: 22-286/288.0
VERRSDVFEEFRDVPQIIARADEVPPGCEDKNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGPRDaPNYYIACQAPLESTTSDFWRMIWEQQSRVI
. .  . |||....   . .   . |   .|||| ...|.  .||.|.  .... . ||||.|..|..  .. .||.|.||..|..|||||.|||..|||
ltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynl.krkfIatqgPlpntvedFWrmvweqnvrvI

IQATDLSENGIERCAEYLPPsatlDNHSSYGDYQVTLKHREVKDRYAISTLVLKRV----DGEESRELTHYWYK-WPEAGVPAEEAPIIAMLLEARsslk
.  |.| |.| | || | |.    ...  |||..|||.. ||.| | . || ....     ..|||. ||..|. ||. |||    .....| ..|    
vmltklvelgrekcaqYwpl....ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvr....

sysleqanelreksatletsmdadgskaeagstssheingnissR--SgtrSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETPkRSVDIPQLVYYVRRG
                                            .  .   |..||  |||| | |||||.|| |.... ||.  . ||....| ..|. 
............................................kala...sgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreq

RASAVQTKEQYEFIYKVASMYA
|  .||| |||.|.|... .|.
Rpgmvqtpeqyrfvyealleyl
0050432 (Phosphotyrosine protein) phosphatases II 1107-1422 7.9e-72 237.5 In-house 43-302 (308) alignment 
Range on Protein: 1107-1422
Range on HMM: 43-302/308.0
RRSDVFEEFRDVPQIIARADEVPPGCEDKNRYANVIPLPETRVVLqrqgdDDKTEYINANYVRGPR-DAPNYYIACQAPLESTTSDFWRMIWEQQSRVII
. .  |||...|. .. .     |   ||||| ...|.  .||.|     |... ||||.||.|.  . |. .||.|.||..|. |||||.|||..|||.
lleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIv

QATDLSENGIERCAEYLPPSAtlD-NHSSYGDYQVTLKHREVKDRYAISTLVLKRVDGEESRELTHYWY-KWPEAGVPAEEAPIIAMLLEARsslksysl
  |.| |||.| ||.| |..   . .   ||...|||.. ||.| | . || |. ....|||..||..|  ||. ||| . ......| ..|        
mLtklvengrekcaqYwplel..gggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvr........

eqanelreksatletsmdadgskaeagstssheingnissrsgT-RsQQGPLTVHCSPGTGRTGTIIASDMAIRSLETPkRSVDIPQLVYYVRRGRASAV
                                           . . ..||  |||| | |||||.|| |.... ||.  . ||....|...|. |. .|
...........................................ksl.pggpivVHCsaGvGRtGtfialdllleqleke.ggvdvfeavkklReqRpgmv

QTKEQYEFIYKVASMYAAKI
||.|||.|.|... .|. ..
qtpeqylflyralleylklk
subfamily_PTPN14_pd Subfamily PTPN14 1108-1298 2.7e-37 123.4 In-house 22-216 (300) alignment 
Range on Protein: 1108-1298
Range on HMM: 22-216/300.0
RSDVFEEFRDVPQIIARADE---VPPGCEDKNRYANVIPLPETRVVLQRQGDDdKTEYINANYVRGPRDA-PNYYIACQAPLESTTSDFWRMIWEQQSRV
 . || |.  .|.  . |.      |  ..|||. .|.|  ..|| |. . .. .|.||||  .. .  .    ||..|.||| |  |||.|.|||. ..
egkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvql

IIQATDLSENGIERCAEYLPPSATLDNHSSYGDYQVTLKHREVKDRYAISTLVLKRVDGEESRELTHYWY-KWPEAGVPAEEAPIIAMLLEARSSL
|.. |.  |.| |.. .|.| .    ..  .| ..|| | .|  |... ..| || .  .| |.. |  |  ||. ||| .  . .  | | .|  
ivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvr
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1109-1423 1.5e-66 219.3 In-house 5-272 (274) alignment 
Range on Protein: 1109-1423
Range on HMM: 5-272/274.0
SDVFEEFRDVPQIIARADEVPPGCEDKNRYANVIPLPETRVVLQR-QGDDDKTEYINANYVRGPRDAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQA
 |. .|| ..|    ....  .| . |||| ...| ...||.|.. ...|....||||||..|..   . |.| | || .| .||||||......||.  
kdlekeflelPlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivml

TDLSENGIERCAEYLPPSATLDNHSSYGDYQVTLKHREVKDRYAISTLVLKRVDGeeSRELTHYWY-KWPEAGVPAEEAPIIAMLLEArsslksysleqa
|.|.|.  ..||.| | .  .. .  ||| ... ..   .. | . .|||| .    .|...|||| .||.  .| .  ... ..||             
tklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvlev............

nelreksatletsmdadgskaeagstssheingnISSRSGTRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETpKRSVDIPQLVYYVRRGRASAVQTKE
                                   .||. .  . .|  |||| | ||||  || ..|.| |.  .  ||. ..|  .|  |   |||.|
..................................eesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlre.eivvdvlkivcnlrldrGGmvqtse

QYEFIYKVASMYAAKIT
|||.|... ..|. ...
qyelihralclylkrll
subfamily_PTPRB_pd Subfamily PTPRB 1109-1298 3.9e-44 145.9 In-house 28-212 (293) alignment 
Range on Protein: 1109-1298
Range on HMM: 28-212/293.0
SDVFEEFRDVPQIIARADEVPPGCEDKNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGPRdAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQAT
|. .||...| .  | .    .  ..|||| |..|  ..|| |.   |.....||||||..| . .|. .||.| || .|. |||||.||..|..|.  |
seeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgyn.sprefiatqGPlpetvddfWrmvwekkssiivmlt

DLSENGIERCAEYLPPSatlDNHSSYGDYQVTLKHREVKDRYAISTLVLKRvdGEESRELTHYWY-KWPEAGVPAEEAPIIAMLLEARSSL
.| |.| ..| || |     ..   ||| .|||.. |... ..| .| ...  ..|.|....| .  ||. ||| . ....... . |...
qlvekgkvkCeeYWPad...eepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreai
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1109-1302 1.9e-23 77.5 In-house 19-169 (392) alignment 
Range on Protein: 1109-1302
Range on HMM: 19-169/392.0
S-DVFEEFRDVPQ--IIARADEVPPGCEDKNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGpRDAPNYYIACQAPLESTTSDFWRMIWEQQSRVII
|  .||||.|.|.  |  ..    .    |||| |..|. ..||.|.   |  ...|.|| |...  |. . |||.|.|  .. .|||||.....   |.
salffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyips.fdnekayiasqgpnaaslddfwrmvfqenvttia

QATDLSENGiercaeylppsatldnhssygdyqvtlkhrevkdryaistlvlkrvDGEESRELTHY-WYKWPEAGVPAEEAPIIAMLLEARSSLKSYS
  |.| |                                                 |.. |  . . . .||...||   . .. .. | ..   .|.
mvtklkegd..............................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqyt
subfamily_PTPRA_pd Subfamily PTPRA 1111-1294 1.5e-35 117.7 In-house 34-220 (330) alignment 
Range on Protein: 1111-1294
Range on HMM: 34-220/330.0
VFEEFRDVPQ-IIARADEVPP--GCEDKNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGPRDApNYYIACQAPLESTTSDFWRMIWEQQSRVIIQA
. |||  .|   |  . |.      ..|||. |..|   .||.|. .   ....|||| .. | ..  ...||.| |.| |  |||||||||.|  |.  
freefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykek.dkfiaaqGPkeetvedfwrmiweqksativml

TDLSENGIERCAEYLPPSATldnhSSYGDYQVTLKHREVKDRYAISTLVLKRV----DGEESRELTHYWY-KWPEAGVPAEEAPIIAMLLEA
|.| |   |.|| | |   .     .||. .|.... .|   |..  ......    . ..|| .. . .  ||. |||.|   .. .| . 
telkerkeekcaqywPdeGl....vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkv
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1111-1300 1.6e-28 94.1 In-house 19-207 (515) alignment 
Range on Protein: 1111-1300
Range on HMM: 19-207/515.0
V-FEEFRDV--PQIIARADEVPPGCEDKNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGpRDAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQA
.  |||.|.  |.|  ..         |||| |..|.  .|| |.   |. . .|.|| |...  |. . ||| |.|......||||......   |.  
lfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyips.fdndkayiasqgPnkasvddfWrlvlqenvttiamv

TDLSENGIERCAEYLPPSATldNHSSYGDYQVTLKHREVKDRYAISTLVLKRvdGEESRELTHYWY-KWPEAGVPAEEAPIIAMLLEARSSLKS
|.|.|.   .|..| |   .  .   .| ..| |   |      . .| . .  |..|| .| . . .||. ||| .   .. .. | ...   
tklkegdkikcgkyWPdkpg..dsvkfGsikvelvsleactggikrkltvlk..gddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgq
0036941 (Phosphotyrosine protein) phosphatases II 1112-1422 3.3e-69 228.8 In-house 19-280 (297) alignment 
Range on Protein: 1112-1422
Range on HMM: 19-280/297.0
FEEFRDVPQIIARADEVPPGCEDKNRYANVIPLPETRVVLqrqgDDDKTEYINANYVRGPrDAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLS
|||. ..  .. .     |.  .|||| ...|.. |||.|    ||... ||||.|| |. | .. .||.|.||..|. |||||.|||...||.  |.| 
feellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgy.dlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelv

ENGIERCAEYLPPSatLDNHSSYGDYQVTLKHREV--KDRYAISTLVLKRVDGEESRELTHYWYK-WPEAGVPAEEAPIIAMLLEARSSLKSYsleqane
|.| | ||.| |.    ..   |||..|||.. ||  .| | . || .. ....|||..||..|. ||. |||   |...... ..|. || .       
elgrekcaqywple..egesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkll.......

lreksatletsmdadgskaeagstssheingnissrsgtrSQQGPLTVHCSPGTGRTGTIIASDMAIRSLET--PKRSVDIPQLVYYVRRGRASAVQTKE
                                         ..||  |||| | ||.||.|| |.... ||.    . |||...| ..|. |. |||| |
........................................psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtle

QYEFIYKVASMYAAKI
||.|.| .  ..  |.
qyrflyeallellkkk
0047943 (Phosphotyrosine protein) phosphatases II 1112-1418 3.2e-67 222.2 In-house 18-271 (273) alignment 
Range on Protein: 1112-1418
Range on HMM: 18-271/273.0
FEEFRDVPQIIARADEVPPGCEDKNRYANVIPLPETRVVLqrqgDDDKTEYINANYVRGPrDAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLS
||...... .. .   . |   ||||| ...|.  .||.|    .|... ||||.||.|. . .. .||.|.||..|. |||||.|||..|||.  |.| 
felllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgy.nlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelv

ENGIERCAEYLPPSatLDN-HSSYGDYQVTLKHREVKDRYAISTLVLKRVDGEESRELTHYWYK-WPEAGVPAEEAPIIAMLLEARSSLKsysleqanel
|.| | || | |..   .. .  ||...|||.  |.|| | . || |.... .|||. ||..|. ||. |||.  .... .. ..|. |.          
elgrekcaqYwple..ggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkale..........

reksatletsmdadgskaeagstssheingnissrsgTRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETPkRSVDIPQLVYYVRRGRASAVQTKEQYE
                                     .  ..||  |||| | |||||.|| |.... ||.  . ||....|...|. |  .||| |||.
.....................................alpsngpvvVHCsaGvgRtgtfialdllldqleke.ggvdvleavkllrsqRpgmvqtpeqyr

FIYKVASMY
|.|... .|
flyealley
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1112-1294 7.2e-43 141.8 In-house 26-204 (318) alignment 
Range on Protein: 1112-1294
Range on HMM: 26-204/318.0
FEEFRDVPQIIARADEVPPGCEDKNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGPRDApNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLS
.|..  ... ... . . |  . ||||||...  .||| || . .. ...||||||. | |   . |||.||||  | .|||||.|||.|.||.  |...
yerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrk.kayiaaqaPlpetieDfWrmvWeqnsavivmltqee

ENGIERCAEYLPPSATldnhSSYGDYQVTLKHREVKDRYAISTLVLKRVDGEESRELTHYWY-KWPEAGVPAEEAPIIAMLLEA
|.| .... | | . .     |||. .|.||..   . | . .. ..| . ||||.   | | .||. |||.. | ..... ..
ergkakvhryWPskgs....rsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqv
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1112-1275 1.7e-16 55.0 In-house 12-165 (267) alignment 
Range on Protein: 1112-1275
Range on HMM: 12-165/267.0
FEEFRDVPQIIAR-ADEVPPGCEDKNRYANVIPLPETRVVLQRQGDDdkteYINANYVRGPRdAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDL
||. . . .. .. .  ..   ...||. ...|  .|||.|. . ..    |||| || | .   | .|. | ||. | .||. .| .|.  ||.  |  
felikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyk.tknafivtqdplkntitdfltvihdqkvpvivlltkv

SENGIercAEYLPPSatLDNHSSYGDYQVTLKHREVKDRYAISTLVLKrVDGEESRELTHYWYKW
 .. |     . ||   . .   | |  |     . .. | | || || .  | ....| |.|| 
ftdni...rlfwPPk..mgqakkyqdltvehslekeendyqiitlelk.fknesahnvtlyyykk
0043336 (Phosphotyrosine protein) phosphatases II 1113-1418 2.3e-65 216.1 In-house 27-276 (278) alignment 
Range on Protein: 1113-1418
Range on HMM: 27-276/278.0
EEFRDVPQiIARADEVPPGCEDKNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGPRDAPNyYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSE
||.....  . .     |   ||||| ...|.. .||.|.  | |  . ||||.|| |..  .. .||.|.||..|. |||||.||.....|.  |.| |
eellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprk.fiatqgPlpetvedFwrmvwelgvttivmLtelve

NGIERCAEYLPpsatlDNHSSYGDYQVTLKHREVKDRYAISTLVLKRVDGEESRELTHYWY-KWPEAGVPAEEAPIIAMLLEARSSLksysleqanelre
.| . ||.| |     ...  |||..|||.  |..| | . || ...    |||. |||.| .||. |||   .... .| ..|. |             
lgrvkcaqYwp.....ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreal.............

ksatletsmdadgskaeagstssheingnissrsgtRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETPKrSVDIPQLVYYVRRGRASAVQTKEQYEFI
                                    ....||. |||| | |||||.|| ..... ||. .  ||... | ..|. |..|||| .||.|.
....................................edsngpvlVHCsaGvgRTGtfialyllleqlekeg.gvdleeavkelreqRpgavqtpsqyrfl

YKVASMY
|... .|
yealley
subfamily_PTPN6_pd Subfamily PTPN6 1113-1298 1.4e-40 134.2 In-house 30-219 (306) alignment 
Range on Protein: 1113-1298
Range on HMM: 30-219/306.0
EEF-----RDVPQIIARADEVPPGCEDKNRYANVIPLPETRVVLQrQGDDDKTEYINANYVRG-PRDAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQ
|||     ... . . | .   |  . |||| |..|  .|||.|. . .   ..||||||...  ..  ..||| |  ||.| ||||||.|...||||. 
eefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivm

ATDLSENGIERCAEYLPPSATLDNhssYGDYQVTLKHREVKDRYAISTLVLK-RVDGEESRELTHYWYK-WPEAGVPAEEAPIIAMLLEARSSL
.|   | | |.|| | | . . ..   ||...||  . . ...| . .|... . ...|.||. .| .| ||..|||..   ....| . ..  
ttkevErgkekCarYWPdeeekee...yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkq
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1113-1299 1.8e-29 97.6 In-house 23-207 (315) alignment 
Range on Protein: 1113-1299
Range on HMM: 23-207/315.0
EEFRDVPQI--IARADEVPPGCEDKNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGPrDAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDL
|||.|.|.     .     .    |||| |..|| ..||.|.   |. . .|||| |...  |  . ||| |.||... .|||||.....   |.  |..
eefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksv.dddkayiasqgPlkasvddfwrmvlqekvttivmvtkk

SENGIERCAEYLPPSATldNHSSYGDYQVTLKHREVKDRYAISTLVLKrvDGEESRELTHYWY-KWPEAGVPAEEAPIIAMLLEARSSLK
.|.   .|. | |   .  .   .| ..|.|   |      .  ||..  ..|||| .| . . .||. ||. . . .. .. | ... .
qegdkikcrqywPdrka..dsvefGsikvellsleadtdgvarklvtr..kseesrtvtqfqftewPdkGvdkqtssllklikevkadng
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1116-1291 7.6e-29 95.8 In-house 30-204 (325) alignment 
Range on Protein: 1116-1291
Range on HMM: 30-204/325.0
RDVPQII--ARADEVPPGCEDKNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGPRDaPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLsEN
  .|     |.   . |   .|||. ||..| ..||||. ..|| ...||||.|.|  ..  . ..|.|||| .|. |.||.. . .. |..    | ..
gllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkk.kdvflaaqaPltatindlWrlvldWrcsvvvvlnel.dl

GIERCAEYLPPSatLDNHSSYGDYQVTLKHREVKDRYAISTLVLKRVDGEESRELTHYWY-KWPEAGVPAEEAPIIAML
| .||| | |    . .   .|  .| |.  |    |    | .|.|.. |.| .  . .  |.. ||.   | .|..|
gkdrcavywpke..mgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisil
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1117-1288 6.6e-15 49.5 In-house 40-211 (305) alignment 
Range on Protein: 1117-1288
Range on HMM: 40-211/305.0
DVPQIIARADEVPPGCEDKNRYANViPLPETRVVLQRQGDddKTEYINANYVRGPRDAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIE
|. |..  |.. .   . ||||..| |  .  .|.  .     ..|| ||||  |    . .|..| ||. |  .|| |. ...   |.      | |  
dmtqvafnanqsadiaitknryqdv.pcqdqsavkldkps..psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgkl

RCAEYLPPSATLDNHSSYGDY--QV-TLKHREVKDRYAISTLVLKrVDGEESRELTH-YWYKWPEAGVPAEEAPII
.||.| | .     .   |    .|   |  |      |..| |    |...  . |  | .||. |||      .
kcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnlt.ysgdqkmsvrhlqwtewpdrgvppckltsl
0045098 (Phosphotyrosine protein) phosphatases II 1118-1420 9.1e-64 210.8 In-house 19-273 (278) alignment 
Range on Protein: 1118-1420
Range on HMM: 19-273/278.0
VPQIIARADEVPPGCEDKNRYANVIPLPETRVVlqrqgdddktEYINANYVRGPrdaPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIER
 ...    . . .|. ||||| ...|.. .||.          .||||.|..|.   |. .||.|.||.||..|||||.||....||. .|.| |.| | 
lgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrek

CAEYLPPsatlDNHSSYGDYQVTLKHREVKDRYAISTLVLKRV----DGEESRELTHYWY-KWPEAGVPAEE--APIIAMLLEARSSLK---SYSLEQAn
||.| |.    ...  |||..|||.  || | | . || .  .     . |||..||..|  ||. ||| ..  .... .| . |. ||   |. |  . 
caqywpe....ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssl.

elreksatletsmdadgskaeagstssheingnissrsGTRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLetpKRSVDIPQLVYYVRRGRAS-AVQTKE
                                       . ...||  |||| | |||||..| .. .. |   .. ||... | ..|. |   |||..|
......................................llldsggpvlVHCsaGvgRtGtlvaaylmlell...eggvdlleavkelrsqRpglavqnle

QYEFIYKVASMYAA
||.|.|... ..  
qyrflyefllelll
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1119-1290 3.4e-23 76.9 In-house 24-183 (283) alignment 
Range on Protein: 1119-1290
Range on HMM: 24-183/283.0
PQIIARADEVppgcEDKNRYANVIPLPETRVVLQRQGDddktEYINANYVRGPRD--APNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIE
.  || |||     . |||. ...|    || |. .      .|||| ..   ..    . ||..|.||. |  |||.|.....   |.  | | |.  .
dadiasaden....krknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlri

RCAEYLPPSATLDnhssYGDYQVTLKHREVKDRYAISTLVLKRV-DGEESRELTHYWY-KWpeagVPAEEAPIIAM
.|. | |   . |    ||.. |||..   .. . |  |.|.     ...  |.|| .  |    .  .| .||  
kCsqyWPkrGsed....yGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW....leygeqaiins
subfamily_PTPRD_pd Subfamily PTPRD 1120-1420 7.3e-70 231.2 In-house 37-282 (564) alignment 
Range on Protein: 1120-1420
Range on HMM: 37-282/564.0
QIIARADEVPPgCEDKNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGPRdAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCA
|   .| . |     ||||||...  ..||||..   |....||||... | | ... ||| |.||..|..|||||.|||.|..|.  | |.|.| ..|.
qftweaankpa.NkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkch

EYLPPSatlDnHSSYGDYQVTLKHREVKDRYAISTLVLKRVDGEESRELTHYWY-KWPEAGVPAEEAPIIAMLLEARSSLKsysleqanelreksatlet
.| | .   . . .||...|||.. | .  | | |. ||. . .|||| ... . .||. ||| . ....... . |.. .                   
kYWPek...g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne...................

smdadgskaeagstssheingnissrsgtrSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETpKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASMY
                              ...||..|||| | ||||| |. |. .. ... .. ||| | |  .|. |   |||.||| ||...   .
..............................pdagPivVhCSaGVGRTGtfividamlerike.ektvDiyqyvkalrkqRnamVqteeQYiFiheailea

AA
 |
la
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1120-1296 2e-45 149.9 In-house 6-189 (270) alignment 
Range on Protein: 1120-1296
Range on HMM: 6-189/270.0
QIIARADEVPPGCEDK--NRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGPRDAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIER
.  .  ...|    .|  ||||...| |.|||.|..  .|..|.|||||||||  .....||| ..||..|...|||||||.... |. .|.| |.| ..
keetsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkk

CAEYLPPSATLDNHSSYGDYQVTLKHREVKDRYAISTLVLKrVDGEESRELtHYWY-KWPEAGVPAEEA------PIIAMLLEARS
|. | |...    . ..|. .|.  . | .. | .  | |.  .||| | . |.|| .||. ||| ||        ...|| . | 
CerYWpaepkekvkledgkikvlalseekeegyiltrlrle.ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrr
0045450 (Phosphotyrosine protein) phosphatases II 1126-1418 5.5e-65 215.4 In-house 49-303 (307) alignment 
Range on Protein: 1126-1418
Range on HMM: 49-303/307.0
DEVPPGCEDKNRYANVIPLPETRVVLQRQGDD-DKTEYINANYVRGPRD-------APNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIER
    |   ||||| ...|.. |||.|.  ... . . ||||.||| |.         .. .||.|.||..|  |||||.|||...||.  |.| |.| | 
iallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrek

CAEYLPPSatlDNHSSYGDYQVTLKHREVKDRYAISTLVLKRV-DGEESRELTHYWY-KWPEAGVPAEEAPIIAMLLEARSSLKSysleqanelreksat
||.| | .   . .  ||...|||.  |..| | . || ...    .|||..||..| .||. |||   ....... |.|. |..               
caqywPde...geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkalee...............

letsmdadgskaeagstssheingnissrsgtRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETPKRS--VDIPQLVYYVRRGRASAVQTKEQYEFIYK
                                 ...||  |||| | |||||.|| ....| ||. .    ||... | ..|. |  |||. |||.|.|.
................................lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflye

VASMY
.. ..
allel
0046845 (Phosphotyrosine protein) phosphatases II 1127-1422 1.9e-73 242.6 In-house 23-277 (284) alignment 
Range on Protein: 1127-1422
Range on HMM: 23-277/284.0
EVPPGCEDKNRYANVIPLPETRVVLQRQGDD-DKTEYINANYVRGPR----DAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEY
 . |   .|||| ...|.  .||.|.. ..| . ..||||.||.|.     . .. .||.|.||..|. |||||.|||..|||.  |.| ||| | || |
allpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqY

LPPSatlDNHSSYGDYQVTLKHREVKDRYAISTLVLKRVD-GEESRELTHYWYK-WPEAGVPAEEAPIIAMLLEARSSLKSYSLEqanelreksatlets
 |..   ..   |||..|||...|||| | . || |.... ..|||..||..|. ||. |||.. ......| ..|..|.... .               
wple...gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgg...............

mdadgskaeagstssheingnissrsgtrsqqGPLTVHCSPGTGRTGTIIASDMAIRSLETPKR--SVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASM
                                ||  |||| | |||||.|| |.... ||. ..   ||....|...|. |  .||| |||.|.|... .
................................gpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealle

YAAKI
|. ..
ylklk
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1129-1290 3.3e-26 86.9 In-house 44-198 (287) alignment 
Range on Protein: 1129-1290
Range on HMM: 44-198/287.0
PPGCEDKNRYANVIPLPETRVVLQrqgdDDKTEYINANYVRGPRDAPNyYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPSATl
 .  .||||......  . ||.|.    . . .|||| .. | ... . .|....|. .|  .||..|....  .|.  ... ||  | | .| | ... 
asqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekka.fiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.

dnhSSYGDYQVTLKHREVKDRYAISTLVLKRVD-GEESRELTHYWY-KWPEAGVPAEEAPIIAM
    ..|.|...| ..||.. | . .| .|. .  .. .... | . .|.. |  .| . |. .
...vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillv
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1129-1291 8.5e-19 62.7 In-house 38-202 (307) alignment 
Range on Protein: 1129-1291
Range on HMM: 38-202/307.0
PPGCEDKNRYANVIPLPETRVVLQRQGDddKTEYINANYVrGPRDAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPSATL
     ||||| .|     .|.|.. .|    ..|| |||. |    |. .|..| |||.|  .|| |. ...   .|   .. | .  .| .| |     
fsantdknryqdvkcqdkgrivvkfdgl..asdyihanyl.giaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegq

DNHSSYGDYQVTLKHREVK----DRYAISTLVLKRVDGEESRELTHY-WYKWPEAGVPAEEAPIIAML
 .  .     ....   .|    |   |    || . ...|| ..|. | .||. |||  .   | .|
klvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainll
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1130-1296 2.3e-38 127.2 In-house 54-216 (298) alignment 
Range on Protein: 1130-1296
Range on HMM: 54-216/298.0
PGCEDKNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGPRDAPnYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPSatld
|  ..|||||..|.|  .||||... .|....|||| .. . .. .  .||.||||..|..|||||..|... .|.  |.| | .  .. .| | .    
penkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn.afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPde....

NHSSYGDYQVTLKHREVKDRYAISTLVLKRVDGEESRELTHYWY-KWPEAGVPAEEAPIIAMLLEARS
..  ||. .|.|...|..  ... .| ... . |..||. .  . .||. |||...  ....| . | 
gketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1130-1292 4.5e-38 125.9 In-house 45-202 (288) alignment 
Range on Protein: 1130-1292
Range on HMM: 45-202/288.0
PGCEDKNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGPRDaPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPSatlD
.  ..|||| |..|. |.|| |.   . ....||||.|. | .   . ||| |.|| .|  |||....|...  |.  |.| |.| ..| || | .   |
avnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekk.kkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPda...d

NHSSYGDYQVTLKHREVKDRYAISTLVLKrvDGEESRELTHYWYK-WPEAGVPAEEAPIIAMLL
..  ||. .|||.. . .. .   .| |.    .. .|.|.| |. ||. |||. .||....| 
kpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellr
subfamily_PTPN1_pd Subfamily PTPN1 1130-1297 5.2e-31 102.4 In-house 30-194 (290) alignment 
Range on Protein: 1130-1297
Range on HMM: 30-194/290.0
PGCEDKNRYANVIPLPETRVVLQRQGDddktEYINANYVRGPRdAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPSATlD
|   ..||| .| |   .|..|.|.      .||||. |  .. |   ||  | || .|.. ||.|.|||.|. ..    . |..  .||.| |     .
penrnlnryrdvspydhsrikleradn....dyinaslvelee.akrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee.e

NHSSYG--DYQVTLKHREVKDRYAISTLVLKRVDGEESRELTHYWY-KWPEAGVPAEEAPIIAMLLEARSS
.   .    ..|.| ..|.|. | ...| |. .  .|.||..|. | .||. |||   |  . .| . |.|
kellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvres
subfamily_PTPRN_pd Subfamily PTPRN 1130-1289 1.1e-28 94.8 In-house 54-211 (297) alignment 
Range on Protein: 1130-1289
Range on HMM: 54-211/297.0
PGCEDKNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGPRDAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPsatlD
. . .|||...|.|  ..|| |... ...|..||||  .         |||.|.|| || .|||.|.||| . ||.. | |.|.|...|..| |     .
eknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpd....e

NHSSYGDYQVTLKHREV-KDRYAISTLVLKRVDGEESRELTHYWY-KWPEAGVPAEEAPIIA
 .. |. |.| |    .  | | . .. || .. .|.| .| . .  ||| ||||.  ... 
GsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasakslle
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1131-1283 1.5e-25 84.6 In-house 32-182 (297) alignment 
Range on Protein: 1131-1283
Range on HMM: 32-182/297.0
GCEDKNRYANVIPLPETRVVLQRQGddDKTEYINANYVRGPR-DAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPSATld
..  |||| ...   .||| |.|     ...||||.||  |  .|. .||  | ||..|  |||....||. |||.  . | |.| ..|| | | .    
sslrknryrdilatddtrvkllrvi..terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvq..

NHSSYGDYQVTLKHREVKD--RYAISTlvLKRVDGEESRELTHYWY-KWPEAGVPAE
.    ||. |    .   .  |  ..   |. .  .||| ..|  .  ||. |||..
erlkagdvvveflsstsdefdrvilte..lqliyrsesrvvrhvqflswpdhGvpsd
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1131-1293 4.6e-22 73.0 In-house 36-195 (281) alignment 
Range on Protein: 1131-1293
Range on HMM: 36-195/281.0
GCEDKNRYANVIPLPETRVVLQR-QGDDDKTEYINANYVRGPRDApNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPSATLd
  . ||||.|.  |  .|| |.    . . |.|| |||.| |      ||  | | . | .|||||||....  |.   .. |   |.||||.|  |   
vnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflk.rgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahc.

nHSSYGDYQVTLKHREVKDRYAISTLVLKrVDGeESRELTHY-WYKWPEAGVPAEEAPIIAMLLE
    .  . |. .   |.     . | |   .| |.| .||. | .||.  ||     .. .| .
.clqfdklsvsyedstvnkslvttrlnls.yeg.etrlithwlwkewpdwqvpessevmlkilrk
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1131-1172 3.9e-06 20.7 In-house 38-78 (244) alignment 
Range on Protein: 1131-1172
Range on HMM: 38-78/244.0
GCEDKNRYANVIPLPETRVVLQRQgDDDKTEYINANYVRGPR
    |||| |..|. ||||.|      . ..||||||..| .
anatknryinilpfdetrvilsss.kkegsdyinanyiqgsq
subfamily_PTPN9_pd Subfamily PTPN9 1132-1304 4.7e-42 139.0 In-house 42-212 (297) alignment 
Range on Protein: 1132-1304
Range on HMM: 42-212/297.0
CEDKNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGPRDaPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPsaTLDNH
   ||||..|. . ||||||... .|....|||||.| | .  .. .|| | ||. |.||||||.|||. .||. .| . |.|  .|..| |.  . .. 
nleknrytdvlcydetrvvlakvdedeasdyinanfvdGykq.kkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpl..eeess

SSYGDYQVTLKHREVKDRYAISTLVLKRVDGEESRELTHYWY-KWPEAGVPAEEAPIIAMLLEARSSLKSYSLE
...||..|.  . |... | ...|..|.|. ||||..||. .  ||. ||| . | .. .| ..|.   . . |
aefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavke
subfamily_PTPN13_pd Subfamily PTPN13 1132-1296 1.7e-34 114.4 In-house 37-197 (273) alignment 
Range on Protein: 1132-1296
Range on HMM: 37-197/273.0
CEDKNRYANVIPLPETRVVLQRQGDddkteYINANYVRGPRDAPNY-YIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPSATlDN
 .||||| ||.|  |||| |. .|      ||||.... | .  .| ||||| ||  |..|||.|.|||...||.  |   |.|  .|  | | |.  ..
nkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPeskn.kk

HSSYGDYQVTLKHREVKDRYAISTLVLKRVDGEESRELTHY-WYKWPEAGVPAEEAPIIAMLLEARS
   .. ..|.| . . .| .....| .| .. .||||..|  . |||. |||.. |... .. | |.
lkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrr
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1132-1289 3.1e-34 113.4 In-house 41-194 (281) alignment 
Range on Protein: 1132-1289
Range on HMM: 41-194/281.0
CEDKNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGPrDAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPSATldnH
   |||| |..    |||..... .. .|.|||||.| |  . .. |||.|.|. ..  .||.|.|||. ..|.  |   |.|  .|  | |  ..   .
nvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgy.kgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddns...e

SSYGDYQVTLKHREVKDRYAISTLVLKRVDGeESRELTHYWY-KWPEAGVPAEEAPIIA
 .|||..|. ...| | .|.  .. |.| .| |.||...  | .||. ||||. . .. 
lkygdvtvkstaeeekatyierkfkleresg.etreveqlaytaWPdhGvPattkelle
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1132-1300 3.8e-29 97.0 In-house 61-219 (319) alignment 
Range on Protein: 1132-1300
Range on HMM: 61-219/319.0
CEDKNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGPrDAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATdlsengIERCAEYLPpsatLDNH
  ||||. |...  ...| |.|    . ..|||| .| |    .. |||.| ||. |  ||||||||...  |.  |       ..|..| |    |.  
nkdknriinilafdknvvklerliGeefsdyinasfvtGy.qrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywp....lkiv

SSYGDYQVTLKHREVKDRYAISTLVLKR-VDGEESRELTHYWYK-WPEAGVPAEEAPIIAMLlEARSSLKS
  .. ..| ..  |  . |..  . | .    .. |..| . .. ||. |||   .... .. .  . |.|
ikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlv.kkvrhlts
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1132-1291 8.5e-28 92.0 In-house 46-204 (290) alignment 
Range on Protein: 1132-1291
Range on HMM: 46-204/290.0
CEDKNRYANVIPLPETRVVLQR-QGDDD-KTEYINANYVRGPRDAPNyYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPSatlD
 . .||.||...  . |..|.. .|. | . ||||| |. | ... . ||| |.|...|  |||..||.... .|.  |.  |.| ..|  | | |   |
nkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkq.yiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds...d

NHSsYGDYQVTLKHREVKDRYAISTLVLKRVDG-EESRELTHYWY-KWPEAGVPAEEAPIIAML
... || ....| . |. ..| . .| .|  .  ......|.|    |.. |  .... |. ..
tka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvi
0040438 (Phosphotyrosine protein) phosphatases II 1133-1420 6.7e-68 224.6 In-house 44-277 (317) alignment 
Range on Protein: 1133-1420
Range on HMM: 44-277/317.0
EDKNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGPRDAPNyYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPsatlDNHS
 ||||| ...|.. .||.|.  | |  . ||||.|| ||.  .. .||.|.||..|. |||||.|||...||.  |.| |.| | ||.| |     ..  
kdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk.fIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl....getl

SYGDYQVTLKHREVKDRYAISTLVLKRVDGEESRELTHYWYKW-PEAGVPAEEAPIIAMLLEARSSLksysleqanelreksatletsmdadgskaeags
 |||..|||.  |... . . || ..  ...|||..||..|.. |. |||    .....| ..|..|                                 
tygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal.................................

tssheingnissrsgtRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETPKrSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASMYAA
                ....||. |||| | |||||.|| ..... ||. .  ||... |...|. |. |||| |||.|.|... .|  
................edpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqRpgavqtpeqyrflydalleylk
DSPc_SM00195 1133-1419 1.1e-66 220.3 In-house 27-262 (263) alignment 
Range on Protein: 1133-1419
Range on HMM: 27-262/263.0
EDKNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGPrDAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPSAtlDNHS
..|||| |..|  .||| |... ......||||||..|. . .. |||.|.||.|| .|||||.||.....|.  |. .||| |.|..| | ..  .. .
ksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees..ggke

SYGDYQVTLKHREVKD-RYAISTLVLKRVDGEESRELTHYWYK-WPEAGVPAEEAPIIAMLLEARSSLKSYsleqanelreksatletsmdadgskaeag
 .|...|.|.. | |.  . . || |.  . ||.|..|.|.|| ||. ||| .. .....| ....| ..                              
tfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.............................

stssheingnissrsgtrsqQGPLTVHCSPGTGRTGTIIASDMAIRSLETPKRsVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASMYA
                    .||. |||| | |||||... |.....||. |. ||| ..|  .|  |...|||.||| |||...  |.
....................sgpivVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1133-1419 1.1e-66 220.3 In-house 27-262 (263) alignment 
Range on Protein: 1133-1419
Range on HMM: 27-262/263.0
EDKNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGPrDAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPSAtlDNHS
..|||| |..|  .||| |... ......||||||..|. . .. |||.|.||.|| .|||||.||.....|.  |. .||| |.|..| | ..  .. .
ksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpees..ggke

SYGDYQVTLKHREVKD-RYAISTLVLKRVDGEESRELTHYWYK-WPEAGVPAEEAPIIAMLLEARSSLKSYsleqanelreksatletsmdadgskaeag
 .|...|.|.. | |.  . . || |.  . ||.|..|.|.|| ||. ||| .. .....| ....| ..                              
tfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.............................

stssheingnissrsgtrsqQGPLTVHCSPGTGRTGTIIASDMAIRSLETPKRsVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASMYA
                    .||. |||| | |||||... |.....||. |. ||| ..|  .|  |...|||.||| |||...  |.
....................sgpivVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0039614 (Phosphotyrosine protein) phosphatases II 1133-1420 5.4e-64 211.8 In-house 57-290 (297) alignment 
Range on Protein: 1133-1420
Range on HMM: 57-290/297.0
EDKNRYANVIPLPETRVVLQRQGD-DDKTEYINANYVRGPRDAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIeRCAEYLPPSATldnh
 ||||| ...|.. .||.|.  .. |  . ||||.|| |..  .. .||.|.||..|. |||||.|||...||.  |.| |.|   ||.| |.. .    
kdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg....

sSYGDYQVTLKHREVKDRYAISTLVLKRvdGEESRELTHYWY-KWPEAGVPAEEAPIIAMLLEARSSLKSysleqanelreksatletsmdadgskaeag
  |||..|||.  |..| | . || ...  ..|||..||..| .||. |||   . .. .| ..|. |..                              
.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealae..............................

stssheingnissrsgtRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETPkRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASMYAA
                  ...||  |||| | |||||.|| ..... ||.  . ||... | ..|. |  |||| .||.|.|... ..  
.................lpkggpvlVHCsaGvgRtGtfiaaylmleqleke.ggvdvleavkelreqRpgavqtpsqyrflydallellk
subfamily_PTPN3_pd Subfamily PTPN3 1133-1413 2.1e-50 166.3 In-house 42-269 (280) alignment 
Range on Protein: 1133-1413
Range on HMM: 42-269/280.0
EDKNRYANVIPLPETRVVLQrqgdDDKTEYINANYVRGPR---DAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPsatLD
 .|||| ...|  .||| |.    . .|.|||||||       .. | |||.| ||..|..|||.|.|||.|..|.  |.| |.|  .| .| |     .
lsknryrdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe...te

NHSSYGDYQVTLKHREVKDRYAISTLVLKRVDGEESRELTHYWY-KWPEAGVPAEEAPIIAMLLEARSSLksysleqanelreksatletsmdadgskae
....||...|...... .  |..  ||||. . .|.|....  |  ||. ||| ..| .. .. . |.                                
deleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr..............................

agstssheingnissrsgtRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETpKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYK
                   .... |. |||| | |||| .|. ..|.  .|. ...| ....|  .|  ||. |||..||.|. .
...................sgkeePvvvhCsaGigrtGvlilletalaliea.aepvypldivrtmrdqramlvqtasqykfvCe
subfamily_PTPN23_pd Subfamily PTPN23 1133-1423 3.1e-47 155.8 In-house 44-284 (288) alignment 
Range on Protein: 1133-1423
Range on HMM: 44-284/288.0
EDKNRYANVIPLPETRVVLQRQGDDdkteYINANYVRGPRDAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPpsATLDNHS
 .|||. ...|  ..||.|. . ||    |||| .|..       .|| ||||.|| .|||.|..||.|.||.  .. .| | .....| |  .  ..  
seknrsrdilPyDhnRvklrgskDD....YinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwP..edkgetv

SYGDYQVTLKHREVKDRYAISTLVLKRVDGEESRELTHYWY-KWPEAGVPAEEAPIIAMLLEARSSLKSYSLEQANelreksatletsmdadgskaeags
..||..||||. .  . .   .| |.  | .. ....|  . .||| ||||    ....| |..|....   .                           
kfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrkskt........................

tssheingnissrsgtrsqqgPLTVHCSPGTGRTGTIIASDMAIRSLETPKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASMYAAKIT
                     || |||| | ||||..     |.| ||. .  .||.|.|  .|. |   ||.|||..| |..   .| .. 
.....................PlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvl
subfamily_PTPN12_pd Subfamily PTPN12 1133-1297 1.9e-38 127.0 In-house 41-202 (290) alignment 
Range on Protein: 1133-1297
Range on HMM: 41-202/290.0
EDKNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGPRDaPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPSatLDNHS
  |||| ...|  ..||.|... .... .|||||...|. . .  ||| |.||  | .||||||||.. .... |  . |.|  .|. | | .   ... 
vkknrykDilPydksrvelskieeeegsdYinanfikgveg.kleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpee..geeel

SYGDYQVTLKHREVKD-RYAISTLVLKRVdgEESRELTHYWY-KWPEAGVPAEEAPIIAMLLEARSS
 .|...|||.. .  |  . | || ...   .|||... . | .||. |||. . ...... ..|. 
efgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrel
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1133-1299 7e-38 125.4 In-house 49-212 (319) alignment 
Range on Protein: 1133-1299
Range on HMM: 49-212/319.0
EDKNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGPRDApNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPsatlDNHS
..|||| |...   |||||.   . ....||||... | ..  . .|| ||||| |..|||||.||..| ...  |.|.|..  .. .| |      |. 
kkknryqnilaydrtrvvlseldgvegsdyinasfidgyqer.ekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpe....enfe

SYGDYQVTLKHREVKDRYAISTLVLKRVDGEE-SRELTHYWY-KWPEAGVPAEEAPIIAMLLEARSSLK
.|| . |||...| .. | |. | |..  .|  .||..|. | .||. .|| .   ....| . | | .
eyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksre
subfamily_PTPRG_pd Subfamily PTPRG 1133-1291 1.1e-37 124.5 In-house 48-209 (563) alignment 
Range on Protein: 1133-1291
Range on HMM: 48-209/563.0
EDKNRYANVIPLPETRVVLQRQGDDDKT-EYINANYVRGPRDaPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPsatlDNH
  |||| |...  ..|| |.   . .|. .||||||. | .   . .|| | ||..|. |||||||||.. .|.  |.| |.| . |  | |     |. 
krKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqk.skafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk....des

SSYGDYQVTLKHREVKDRYAISTLVLKRV-----DG-EESRELTHYWY-KWPEAGVPAEEAPIIAML
  ||  ||||...||.  |.. |||.| .     .  .. .. ..| | |||. |||  ..| . . 
etygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifv
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1133-1296 1.3e-36 121.1 In-house 10-168 (250) alignment 
Range on Protein: 1133-1296
Range on HMM: 10-168/250.0
EDKNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGPRDApNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIErCAEYLPpsatLDNHS
..|||||..|.| ..||||...  |....|||| .. | ..  . .|| |.||..|. |||||..|..| .|.  |.|.|.. . . .|.|     ..  
keknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP....vekae

SYGDYQVTLKHREVKDRYAISTLVLKRVDGEESRELTHYWY-KWPEAGVPAEEAPIIAMLLEARS
 ||| .|.|. .|..  | . .|.| .   ...| . .. .  ||. |||..   ....| . ..
kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqa
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1133-1292 2.8e-32 107.1 In-house 47-205 (305) alignment 
Range on Protein: 1133-1292
Range on HMM: 47-205/305.0
EDKNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGPRDApNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPSATldNHS
. |||......|.. |. |. . ..|...||||.|| | .   . ||. |.||..| .||||.|.| . ..|.. |.| |.| ..|  | | | |  .. 
kaknrlkeitlldddriiltekeslddsdyinasyvdgykrk.kkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpeskt..ekk

SYGDYQVTLKHREVKDRYAISTLVLKR-VDGEESRELTHYWY-KWPEAGVPAEEAPIIAMLL
 .|...|.|| ..    | .  | .    . .||| ...|   .||. ||| . . .. .. 
efgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslik
0049772 (Phosphotyrosine protein) phosphatases II 1133-1423 1e-31 106.3 In-house 47-284 (314) alignment 
Range on Protein: 1133-1423
Range on HMM: 47-284/314.0
EDKNRYANVIPLPeTRVVLQRQGDDDkTEYINANYVRGPrdapNYYIACQAPLESTTSDF----------WRMI--WEQQSRVIIQ--------------
 ||||| ...| . .||.|.... .. . ||||.||.|.    . .||.|.||| |  ||          |||.  .....|.|                
rdknryldilpad.nrvilpglpvsg.sdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLd

-------ATDLSENGiercaeylppsatldnhssygD------Y---QvtlkhrevkdryaistlvlkrvdgE-----ESRE---LTHYWYkwpeaGVPA
        ..|..||                     .      .   .                        |     |  |   ......      || 
aAlgKtpllildgng.....................neptaadlellk........................eelydpelferlgikylri.....pvpD

EEAPIIAMLLEARSSLKSYslEqanelreksatletsmdadgskaeagstssheingnissrsgtrsQQGPLTVHCSPGTGRTGTIIASDMAIRSLetpk
..||......|.   ....  .                                             ..||. |||. | ||||| .. .. .. |    
gsaplledfdeflefieea..d.............................................kggpvlvHCkaGkgRtgtfvvaaylmkll....

rSVDIPQLVYYVRRGRA-----SAVQTKEQYEFIYKVASMYAAKIT
  |.. . . .||. |      ..... ||||||...  .|  .. 
.gvsleealedvrlkRpinpnpgfieqleqyefilealleylkflk
subfamily_PTPRK_pd Subfamily PTPRK 1133-1293 3.3e-30 100.0 In-house 44-201 (314) alignment 
Range on Protein: 1133-1293
Range on HMM: 44-201/314.0
EDKNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGPRdAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPpsatlDNHS
..|||. ....   .||.|.   .| ...||||... . .  |. .|. | ||..|. ||||.......  |.  |.| |.|  .| .| |     .. .
reknrsgdilaydrsrvflitidgdpssdyinaalidsyk.rpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWP.....edte

SYGDYQVTLKHREVKDRYAISTLVLKR--VDGEESRELTHYWY-KWPEAGVPAEEAPIIAMLLE
 ||| .|.| . |..  . . .. ...     || ||. .. . .||. .|| ..  ..... .
vygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrr
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1133-1300 6.3e-29 96.4 In-house 26-183 (284) alignment 
Range on Protein: 1133-1300
Range on HMM: 26-183/284.0
EDKNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGPrDAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATdlsengIERCAEYLPpsatLDNHS
 ||||. ....  ...| |.|    . ..|||| .. |    .. |||.| ||. |  ||||||||...  |.  |       ..|..| |    |.   
kdknrighilafdknvvklerliGeefsdyinasfitGy.qrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywp....lkivi

SYGDYQVTLKHREVKDRYAISTLVLKR-VDGEESRELTHYWYK-WPEAGVPAEEAPIIAMLlEARSSLKS
 .. ..| ..  |  . |..  . | .    .. |... . .. ||. |||   ....... .  . |.|
keerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlv.kkvrhlts
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1133-1295 1e-27 91.7 In-house 39-198 (287) alignment 
Range on Protein: 1133-1295
Range on HMM: 39-198/287.0
EDKNRYANVIPLPETRVVLQRQGDDdKTEYINANYVRGPRDApNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPSatlDNHS
  |||||.|.|. .|||.|  .|.   ..||||||| . .|  . .||.|.|. .|  ||||...|..| ..|  |   |..  .| .| |     .   
vkknryadvlPiddtrvllsaegel.Gsdyinanyvasytdd.eafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer...evPm

SYGDYQVTLKHREVKD-RYAISTLVLKRVDGEESRELTHY-WYKWPEAGVPAEEAPIIAMLLEAR
  | | |.|  ...|.  |.. .| |  ....|.| .  . ...||. ...     .| . |. .
rvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvk
subfamily_CG7180_pd Subfamily CG7180 1133-1252 1.5e-19 64.7 In-house 43-156 (296) alignment 
Range on Protein: 1133-1252
Range on HMM: 43-156/296.0
EDKNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGPRdAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIeRCAEYLPPSAtldnHS
 .|||. .|.|   .||||.. . ..|..|||| || .    .. ||  .|| ..|  .|||.......  ..  |.  .     . .|.|. .    . 
reknrdvkvvPyDynRvvLekldGeeksdYinavyvdsfl.kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks....ke

SYGDYQVTLKHREVKDRYAI
 ||.  | . . .      |
qygeifveiveekqyanlki
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1133-1250 3.3e-19 63.9 In-house 36-145 (285) alignment 
Range on Protein: 1133-1250
Range on HMM: 36-145/285.0
EDKNRYANVIPLPETRVVLQRQgddDkTEYINANYVRGPRDAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPpsATLDNHS
 | ||||.|  . ||||||. .   |  .|| |...| |    . ||. | ||  | ||||.||....   ..    | | |.|.|| | |    | .  
pdlnryadvrcieetrvvlknh...d.rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyyp..eklgevv

SYGDYQVTLKhrEVKDRY
 .| |..||   |.|.  
kfgkyeitlt..eckeea
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1133-1291 2.7e-18 60.8 In-house 51-207 (301) alignment 
Range on Protein: 1133-1291
Range on HMM: 51-207/301.0
EDKNRYANVIPLPETRVVLQRQGdddKTEYINANYVRGPrDAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPSATldNHS
.||.|| .|   |.| | .  .|   |   | ||..  .   |. .|| |.||..|. ||| |.   .   |.  .   |. .|.|.|||| . .  .. 
kdkhryptvPckPstavevivdG...krvPihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis..ekl

SYGDYQVTLKHREVKDRYAISTLVLKRVDGE---ESRELTHYWY-KWPEAGVPAEEAPIIAML
  | .....|..|.  .  ||   |. .|     ..| .||| | .|.. |||   | .  ..
digrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlm
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1133-1282 9.1e-15 49.1 In-house 44-193 (312) alignment 
Range on Protein: 1133-1282
Range on HMM: 44-193/312.0
EDKNRYANVIPLPETRVVLQrqGDDdkTEYINANYVRGPrDAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPS---ATLD
 | ||| |.      |  |   ||.    || ||.|.     |. ....|.|||.|.. ||..     |  ||  . . |.| |.||.|.        |.
kdlnrypniqcwdrgrftla..gde..nfyihanfvkic.tkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdle

NHSSYGDYQVTLKHrEVKDRYAISTLVLKR---VDGEESReLTHY-WYKWPEAGVPA
.|  | .|   ..    | .  |.  |||      |.||. | || |  ||. |.| 
dhrvyteycteiei.ggkskdkithrvlkvvvkatgqesk.lnhyqwaswpdhgmpd
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1133-1283 1.2e-06 21.6 In-house 28-157 (169) alignment 
Range on Protein: 1133-1283
Range on HMM: 28-157/169.0
EDKNRYANVIPLPETRVVLQRQGDDDKTEYINAnyvrgprdapnyyiacqaplesttsdfwRMIWEQQSRVIIQ--ATDLSENGI-ERCAEYLPPSATLD
| ||| |  .    ||| |||  .|  ..||||                            ||||| .. ||.    ||  .|   |.    | |.  | 
etknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlgdtddknnfwpekedyqlhpavilg

NHSSYGDYQVTLKHR----EVKDRYAIStLVLKRVDGEES--RELTHYwYKWPEAGVPAE
.  .   |  | | .     |.  . .| .|... | . .   .| ||   ||. |||  
ewytdslyvrtdkvhantsgveglfevs.mvihsydddvteklsllhy.stwpqngvpqs
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1133-1283 3.4e-06 20.0 In-house 27-156 (169) alignment 
Range on Protein: 1133-1283
Range on HMM: 27-156/169.0
EDKNRYANVIPLPETRVVLQRQGDDDKTEYINAnyvrgprdapnyyiacqaplesttsdfwRMIWEQQSRVIIQ--ATDLSENGI-ERCAEYLPPSATLD
| ||| |  .    ||| |||  .|  ..||||                            ||||| .. ||.    ||  .|   |.    | |.  | 
etknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlGdtddknnfwpekedyqlhpavilG

NHSSYGDYQVTLKHR----EVKDRYAIStLVLKRVDGEESRELTHYWY-KWPEAGVPAE
.  .   |  | | .     |.  . .| ||... | . ...|. . |  ||. |||  
ewytdslyvrtdkvhpntsgveglfevs.lvihsydddvteqlsllhystwpqngvpqs
Y_phosphatase Protein-tyrosine phosphatase 1134-1415 2.7e-63 208.9 Pfam-A 3-233 (235) alignment 
Range on Protein: 1134-1415
Range on HMM: 3-233/235.0
DKNRYANVIPLPETRVVLqrQGDDDKTEYINANYVRGPRdAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPpsATLDNHSS
.|||| ...|  .||| |  .|......|||||||.| .  .. .||.|.||.|| .|||||.|.....||.. |.| |.| | ||.| |   . ..  .
kknRykdilpydktrvkl..kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp..eeeeeslt

YGDYQVTLK-HRE-VKDRYAISTLVLKRVDGE-ESRELTHYWYK-WPEAGVPAEEAPIIAMLLEARSSLksysleqanelreksatletsmdadgskaea
|||..|.|| . .  ...|....| ||  ..| |.||.....|. ||. |||..  ... .. . ..|                                
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk...............................

gstssheingnissrsgtRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETpKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVA
                  ....||..|||| |.|||||..| |.....||. ...||. |.|  .|. |...||. |||.|.||. 
..................eaksgpvvVhCsaGvgRtgtfvaldilleqlea.eeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 1134-1415 2.7e-63 208.9 In-house 3-233 (235) alignment 
Range on Protein: 1134-1415
Range on HMM: 3-233/235.0
DKNRYANVIPLPETRVVLqrQGDDDKTEYINANYVRGPRdAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPpsATLDNHSS
.|||| ...|  .||| |  .|......|||||||.| .  .. .||.|.||.|| .|||||.|.....||.. |.| |.| | ||.| |   . ..  .
kknRykdilpydktrvkl..kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp..eeeeeslt

YGDYQVTLK-HRE-VKDRYAISTLVLKRVDGE-ESRELTHYWYK-WPEAGVPAEEAPIIAMLLEARSSLksysleqanelreksatletsmdadgskaea
|||..|.|| . .  ...|....| ||  ..| |.||.....|. ||. |||..  ... .. . ..|                                
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk...............................

gstssheingnissrsgtRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETpKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVA
                  ....||..|||| |.|||||..| |.....||. ...||. |.|  .|. |...||. |||.|.||. 
..................eaksgpvvVhCsaGvgRtgtfvaldilleqlea.eeevdvlqivkelRkqRpgmvqsleqYiflykai
0040439 (Phosphotyrosine protein) phosphatases II 1134-1418 1.2e-61 203.8 In-house 13-245 (249) alignment 
Range on Protein: 1134-1418
Range on HMM: 13-245/249.0
DKNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGPRDAPNyYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPsatlDNHSS
||||| ...|.. .||.|.  ..   . ||||.|. |..  .. .||.|.||..|..|||||.||....||. .|.| |.| | ||.| |.    ...  
dknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl....ggsle

YGDYQVTLKHREVKDRYAISTLVLKRVDGEESRELTHYWY-KWPEAGVPAEEAPIIAMLLEARsslksysleqanelreksatletsmdadgskaeagst
|||..|||.. |||| | . || |...   |||. .|..| .||. |||   ....... ..|                                     
ygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavr.....................................

ssheingnisS----RsgtrSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETPKRsVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASMY
          .         ...||. |||| | |||||.|| ..... ||. .. ||... | ..|. |  |||. |||.|.|... ..
..........kaleel....pkggpvlVHCsaGvgRtGtfiaaylmleqlekelg.vdleeavkllrsqRpgavqnpeqyrflyeallel
0042113 (Phosphotyrosine protein) phosphatases II 1134-1418 5.7e-59 194.8 In-house 11-242 (245) alignment 
Range on Protein: 1134-1418
Range on HMM: 11-242/245.0
DKNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGPRDAPNyYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPsatlDNHSS
||||| ...|.. |||.|.  | |  . ||||.|| |.|  |. .||.|.||..|. |||||.||.....|.  |.. |.| . ||.| |.    ...  
dknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk.fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl....geslt

YGDYQVTLKHREVKDRYAISTLVLKRVDGEESRELTHYWY-KWPEAGVPAEEAPIIAMLLEARsslksysleqanelreksatletsmdadgskaeagst
|||..|||.  |..| | . || ....   |||| .||.|  ||. |||   . .. .| ..|                                     
ygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvr.....................................

ssheingnissrsG---TrSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETPkRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASMY
                   ...||. |||| | |||||.|| ..... ||.  . |.... |...|. |  |||| .||.|.|... ..
.............kalae.dsngpvlVHCsaGvgRtGtfiaaylmleqleke.lgvsleeavkelrsqRpgavqtpsqyrflyeallel
0037934 (Phosphotyrosine protein) phosphatases II 1134-1418 3.4e-58 192.4 In-house 12-241 (243) alignment 
Range on Protein: 1134-1418
Range on HMM: 12-241/243.0
DKNRYANVIPLPETRVVLqrqgdDDkTEYINANYVRGPrdaPnYYIACQAPLESTTSD----FWRMIWEQQSRVIIQATDLSENGIERCAEYLPpsatlD
.|||| ...|.. .||.|     .. . |||||.....   | ..||.|.||..|. |    ||||.||....||.  |.| |.| | ||.| |     .
sknrysdilpydhsrvkl.....eg.sdyinanliyvt...p.rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.....g

NHsSYGDYQVTLKHREVKDRYAISTLVLKRVD-GEESRELTHYWYK-WPEAGVPAEEAPIIAMLLEARSSLKSYSLEQanelreksatletsmdadgska
..  |||..|||.. |..| | . ||.|...| ....|. .||.|  ||. ||| . ......| |.|. .... .                        
ev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsll......................

eagstssheingnissrsgTRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLetpkrSVDIPQLVYYVRRGRAS-AVQTKEQYEFIYKVASMY
                   .....||. |||| | |||||.|| .. .. |     .||. . | ..|. |   |||| .||.|.|... ..
...................aldsggpvlVHCsaGvgRtGtliaaylmllll.....gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1134-1419 6e-34 112.1 In-house 42-293 (301) alignment 
Range on Protein: 1134-1419
Range on HMM: 42-293/301.0
DKNRYANVIPLPETRVVLQRQG--DDDKTEYINANYVRGPRDApNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPSATldNH
  ||. |. .... |..|. .   |  ..|||||.|. | ... . .|| |.|...|  ||||.||...   |.  |.| |.  ..| .| | | .  ..
alnrfknitvyddnriilkpkpnldlcqreyinasyidgysek.kkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnsea..es

SSYGDYQVTLKHREVKDRYAISTLVLKRVDGEEsrelthywykwpeagvpaeeapiiamlleARSSLKSYSLEQANELREKSATLETSMDADGSKAEAgS
...|  .|||..  |   . |  | .|  || .                               .  ...  ..... ..  .   |.   ||   |   
eefgpftvtlvneqvyPdfvirqlnvkiqdgsn.............................ngyierkfkvksdksswdvlqlqvtdWpqdGvvrep.r

TSSHEINGNISSRsgTRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETpKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASMYA
|  . |.  |  .   .   ||. |||| . .|.|. .. ....         ||. |..  ||| .  ||.| ||| .||.| .|| 
tvLqviddvihrq..qkigggpvvVHCSdtVsrsGvYcsvsiglEQcka.egVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl
0041856 (Phosphotyrosine protein) phosphatases II 1134-1417 6.3e-34 112.5 In-house 3-169 (182) alignment 
Range on Protein: 1134-1417
Range on HMM: 3-169/182.0
DKNRYANVIPLPETRvvlqrqgdddKTEYINANYVRGPRDAPNyYIACQAPLESTTSDFWRMIWEQQSRVIIQATdlsengierCAEYLPpsatldnhss
||||| ...| . .|             |||||...|.. | . .||.|.|| ||. ||.||..|.. ..|. .|         .  | |          
dknrysdilpydhsr..........dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywp..........

ygdyqvtlkhrevkdryaistlvlkrvDGEESRELTHYWYKWPEAGVPAeEAPIIAMLLEARSSlksysleqanelreksatletsmdadgskaeagsts
                           . .|   ...... ||  |||     ..... |....                                    
...........................ellerlgiqylylpwpDhgvpd.ldelldfieevlee....................................

sheingnissrsgtrsqQGPLTVHCSPGTGRTGTIIASDMAIRSletpkrSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASM
                 .||  |||| | |||||..| .. ..       .|.... | .||. |  .|.| .|| |.. .. .
.................ggpvlVHCsaGvgRtgtlvaaylmkkl......gvsleeavklvrsrRpgmvitpnqyfflqlalle
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1134-1288 4.2e-30 99.7 In-house 5-156 (237) alignment 
Range on Protein: 1134-1288
Range on HMM: 5-156/237.0
DKNRYANVIPLPETRVVLQRQGDDdkTEYINANYVRGPRDAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPSatlDNHSS
 ||||.|..    .||||.  | .  ..||||.|..|   .|. |||.| ||||.  |||.|.|...  ||.  | | |.  ..| .| | .   |. ..
iknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst...dqpaa

YGDYQVTLKHREVKDRYAISTL-VLKRVDGEESRELTHYWY-KWPEAGVPAEEAPII
|| . |.||..|    |.. .| . ||.  .| | .  | .  ||. ||| . | ..
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaall
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1134-1287 4.2e-30 99.6 In-house 9-158 (239) alignment 
Range on Protein: 1134-1287
Range on HMM: 9-158/239.0
DKNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGPRDAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPpsatlDNHSS
 ||||||..    .||||..  .| ...||||.|.|    .|. ||| |  .| .. |||||.|...  ||.  | | |   ..| .| |     |. | 
aknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.....dstsk

YGDYQVTLKHREVKDRYAISTLVLKRVDGEESRELTHYWY-KWPEAGVPAEEAPI
| . .|||.. ||   | | |.|. .|   | | . .| .  ||. |||   . .
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatav
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1134-1287 4.3e-30 99.6 In-house 10-159 (239) alignment 
Range on Protein: 1134-1287
Range on HMM: 10-159/239.0
DKNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGPRDAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPpsatlDNHSS
 ||||||..    .||||..  .| ...||||.|.|    .|. ||| |  .| .. |||||.|...  ||.  | | |   ..| .| |     |. | 
aknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.....dstsk

YGDYQVTLKHREVKDRYAISTLVLKRVDGEESRELTHYWY-KWPEAGVPAEEAPI
| . .|||.. ||   | | |.|. .|   | | . .| .  ||. |||   . .
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatav
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1134-1291 3.3e-28 93.5 In-house 51-201 (315) alignment 
Range on Protein: 1134-1291
Range on HMM: 51-201/315.0
DKNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGPrDAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPpsatlDNHSS
.|||| |.|.  ..|| |     |....|.|||.. |  . .. |||.|.|. ..  ||||...|..   |.  |.| |.  ... .| |     |..  
qknryiniiaydksrvqlpllendphsdyvnanfidGy.nkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywp.....dkkvi

YGDYQVTLKHREVKDRYAISTLvlKRVDGEESRELTHYWY-KWPEAGVPAEEAPIIAML
|| . ||.|  ||...|.. ||    | |.. ||.  . |  ||..|||.   |.. . 
yGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnli
subfamily_ptpA1_pd Subfamily ptpA1 1134-1291 1.3e-24 81.7 In-house 49-212 (418) alignment 
Range on Protein: 1134-1291
Range on HMM: 49-212/418.0
DKNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGPrdAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPSATLDNHSS
 ||||.|..|.  ||| |..  | . ..||||||. |    |. .|. | ||  | .|||||.||.. |.|.  .  |||   .|  | |     .. | 
sknrytnilpvnhtrvqlkkiqdkegsdyinanyidga..ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsi

YGD-------YQVTLKHREVKDRYAISTLVLKRVDGEESRELTHYWYK-WPEAGVPAEEAPIIAML
||.       | | |          | |  ..     |.|..|.| |. ||.  .|    |.  .|
ygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqll
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1134-1297 6.8e-23 75.9 In-house 50-218 (305) alignment 
Range on Protein: 1134-1297
Range on HMM: 50-218/305.0
DKNRYANVIPLPETRVVLQRQgddDKTEYINANYVRGPRDaPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPSATLDNHSS
.|||| .|  | . || |.        ||| ||||  | . |. .| .||||| | .||| | ....   |.   .| | | ..|.||..       . .
gknrykdvgcldnnrvklegp...wpheyihanyvstptn.pkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefe

YGDYQVTLKH--------REVKDRYAISTLVLKRVDGEESRELTHY-WYKWPEAGVPAEEAPIIAMLLEARSS
 .. ....|         |.  .     | ..    ||..|  ||| |  ||. |||| .  |. .| .||.|
ekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarps
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1134-1291 6e-22 72.7 In-house 50-200 (439) alignment 
Range on Protein: 1134-1291
Range on HMM: 50-200/439.0
DKNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGPRDaPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIercaeYLPPsatlDNHSS
 |||| .| ..  |||.||      .. ||||||..|  | .. |||.|.| . || ||||...|...  |.. |.| |        | |     |..  
tknrykdvgafdhtrvtlqeipgvphshyinanyikGyyd.dklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywps....daevc

YGDYQVTLKHREVKDRYAISTL--VLKRVDGEESRELTHYWY-KWPEAGVPAEEAPIIAML
|||  |   .     .|.|  .  . .|  .|  | . .. |  ||.  |||. . .. .|
ygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldfl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1134-1295 2.4e-21 70.6 In-house 58-213 (290) alignment 
Range on Protein: 1134-1295
Range on HMM: 58-213/290.0
DKNRYANVIPLPETRVVLQRQGDDDkteYINANYVRGPRdapNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPSAtlDNHSS
 |||| .|.    |||.|.  .| |   |. ||||.| .     .|  | .|..|. |.|||. ...  .|.   .| |.|  .|..| |  .   .  .
kknrykdvvcndktrvilkdGydGd...yvhanyvkGlk...amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypeke..Gevlt

YGDYQVTLKHREVKDRYAI-STLVLKRVDGEESRELTHYWY-KWPEAGVPAEEAPIIAMLLEAR
.|.. |.    . ||   |  || .. .|   .  | |.    ||.  |.  .  .. .|   |
fGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilr
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1134-1225 2.4e-20 67.6 In-house 49-153 (350) alignment 
Range on Protein: 1134-1225
Range on HMM: 49-153/350.0
DKNRYANVIPLPETRVVLQR--Q------GDDDKTEYINANYVRGP----RDAPNY-YIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAE
 |||| |..|   .|| |..  .            .||||||.. .    .  |.. ||| |||| ||  ||...| . . .||.  |.. |...|.| .
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YLPPS
| .  
YWqeg
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1134-1287 5.9e-16 52.9 In-house 54-212 (310) alignment 
Range on Protein: 1134-1287
Range on HMM: 54-212/310.0
DKNRYANVIPLPETRVVLQRQgDDDKTEYINANYVRGPrDAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPpsaTLDNHSS
 ||||..|. | ..|| |. .      .|| ||||.      . .| .| ||. |  ||||||.....  |.     .|.|  .|  | |   .|    .
hknrysdvvcldtsrvklkid.ksryedyihanyvktn.ylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywp...slgvtet

YGDYQVTlKHREVKDRYAISTLVLKRV----DGE-------ESRELTHYWYKWPEAGVPAEEAPI
||  .|| .  |  . . |  | .  |      .       | |     | .||..||| |    
ygcirvt.nlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekcht
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1134-1302 1.6e-10 35.1 In-house 49-209 (303) alignment 
Range on Protein: 1134-1302
Range on HMM: 49-209/303.0
DKNRYANVIPLPETRVVLQrqgddDkTEYINANYVRgpRDAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQ-ATDlSENGIERCAEYLPPSATLDNHS
||||...|| |  ..| |      | . || |.|.    |. .  |  | ||  |..|||.|| ||. ....   || ||         .|    . .  
dknrfvdvicldhskvkls.....d.ssyihasyle..ldsskkailtqlplshtaadfwqmiieqkvkcvlllltd.seydklggdsvfprnqdflkfe

SYGDYQVTLKHREVKDRYAISTLVLKRVDGEESRELtHYWYKWPEAGVPAEEAP-IIAMLLEARSSLKSYS
        .|. |. | ...  | .   |      . |.. .|| . .|.. .| ..  . . .| |. ||
ersirvgefkrvelgdgwvlkvlsvsngdyksflhv.hhykawphnsipsdgspkfvkqiwqlqsvlrkys
subfamily_Ptp69D_pd Subfamily Ptp69D 1135-1296 7.9e-33 108.9 In-house 51-213 (307) alignment 
Range on Protein: 1135-1296
Range on HMM: 51-213/307.0
KNRYANVIPLPETRVVLQRQGDDDKTEYINANYVRGPRDApNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPSatldNHSSY
|||| ....  .|||.|..   .....||||....| ..  . .|| |.|.|.|  ||||||.||.. .|.  ..|.|   ..|| | |      .   |
knRyedikafDktRvkLkkingkedsdYinasfikgykek.kkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie....devqy

GDYQVTLKHREVKDRYAISTLVLKRVD-----GEESRELTHYWY-KWPEAGVPAEEAPIIAMLLEARS
||  |.| . | .. |.| .| . ...      |.||... | |  |..  ||     .. .. ..|.
gdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvre
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1135-1294 1.1e-14 49.2 In-house 46-200 (288) alignment 
Range on Protein: 1135-1294
Range on HMM: 46-200/288.0
KNRYANVIPLPETRVVLQrqgdDDKTEYINANYVRgPRDAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPSATldNHSSY
..|| |.     ||| |.    ||   ||.|| |      ..  | .||||..|   .|.|. |.. . |.  ..| | | |. |||.|      ..  .
rdryenlprcditrvkls....ddpdfyiaanvvs.sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklG..ekari

GDYQ--VTLKHREVkDRYAISTLVLKRVDGEESRELTH-YWYKWPEAGVPAEEAPIIAMLLEA
| .   |  |. .. |.    .|.     |||.  . . .. .|.. ||| .  . . .|   
grlctvvkkkradi.dklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1135-1222 4e-13 43.4 In-house 51-153 (349) alignment 
Range on Protein: 1135-1222
Range on HMM: 51-153/349.0
KNRYANVIPLPETRVVLQRQGDDD--------------KTEYINANYVRGPRDAPN-YYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCA
|||| ...|   .||.|..                     .||||||.. .| ...  ||| |||| ||  ||...|  .. ....  .|  |...|.| 
knrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcd

EYL
 | 
iyw
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1136-1290 1.2e-11 39.3 In-house 23-183 (290) alignment 
Range on Protein: 1136-1290
Range on HMM: 23-183/290.0
NRYANVIpLPETRVVLQRQGDDDKTEYINANYVRGPRDApnYYIACQAPLE-------STTSDFWRMIWEQQSRVIIQATDLSENGIE----RCAEYLPP
.|... . . .|||||.  |   . .|| ||.|  | .     |. |.|.|       ||  .|| |. . ... ...  . .|.  .     ||.| | 
qRlevpL.veatrvvLkgygkrfnddyiHAnrvtcpngl..rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpe

SAtlDNHSSYGDYQVTLKHREVKDRYAISTLVLKrVDGEESRELTHYWYK-WPEAGVPAEEAPIIAM
|.  ...  ... .|  |..| .|   . .||.|  |.||   .||...| | .  |. ..  ....
sv..geelkfkgltvkCkskekeddvetRelvvk.fddeeeftvtHsllkgWnklnvqedtktllsl
subfamily_eak_pd Subfamily eak 1139-1284 1.1e-14 48.6 In-house 58-198 (332) alignment 
Range on Protein: 1139-1284
Range on HMM: 58-198/332.0
ANVIPLPETRVVLQRqGDDDKTEYINANYVRGPrDAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPSAtLdNHSSYGDYQ
 ...|     | |      ..  ||||  .  . .  . ||   .. |.    ||.|. ||.|  |.|  .  |...|.   |.|  .   .  ..| ..
vkivpydrylvrlts.sqlnrlGyinaslaefs.evGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdkt.r.eelkfGild

VTLKHReVKdRYAISTLVLKRVDGEESRELTHY-WYKWPEAGVPAEE
|. |.  || |  . |  |.   |.|. .. ||  . | |  .|  |
verkef.vk.rniletrllelskGnethrvlhykvfGwtettlpkye
0044763 (Phosphotyrosine protein) phosphatases II 1143-1418 2.9e-24 81.1 In-house 1-170 (178) alignment 
Range on Protein: 1143-1418
Range on HMM: 1-170/178.0
PLPETRVVLQRQGDDDKTEYINANYVRgprdaPNYYIACQAPlesttSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPSATldnhssygdyqvtlk
||..|||.|.   .   ..||||...      |..|.... |     .|......|.  ..|.  |.  |.| . | .| | .|                
pldrtrvllsnleglersdyinaseil.....pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............

hrevkdryaistlvlkrvdgeesreLTHYWYKWPEAGVPAEEAPIIAMLLEARSSLksysleqanelreksatletsmdadgskaeagstssheingnis
                         ...... .|  |||   . . ...   .. |                                            
.........................iqylhipipDhgvpdllehflefvefieeal............................................

srsgtRSQQGPLTVHCSPGTGRTGTIIASDMAIRSletpkrSVDIPQLVYYVRRGRAsAVQTKEQYEFIYKVASMY
      ...||  |||| | ||.||..| .. ..       ...... . .||. |  .|.. .|....|......
.....dekggpvlVHCsaGvgRsgtlvaaylmkkl......glsleeaielvrerRp.ivpnpgqlrqLyefelrl
0046846 (Phosphotyrosine protein) phosphatases II 1151-1298 8.3e-14 47.2 In-house 3-106 (176) alignment 
Range on Protein: 1151-1298
Range on HMM: 3-106/176.0
LQRQGDDDKTEYINANYVRGPrdapnYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPSATLDNhssygdyqvtlkhrevkdry
|.. |.|    |||||.. |.     ..||.|.||..|. ||..|..|.. ....  |.. | |  .|. | |   .|.                     
lrllgldldldyinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi....................

aistlvlkrvdgeesrelTHYWYKWPEAGVPAEeAPIIAMLLEARSSL
                  ..... ||. |||   . .. .| . |. |
..................qylhlpwpDhgvpdl.elllellefireal
0043147 (Phosphotyrosine protein) phosphatases II 1157-1418 1.8e-30 101.4 In-house 2-160 (172) alignment 
Range on Protein: 1157-1418
Range on HMM: 2-160/172.0
DDKTEYINANYVRGPRdAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLsengiercaeylppsatldnhssygdyqvtlkhrevkdryaistlv
|. . ||||.|. ...  |. .||.|.|| .|..|||||..|.. ..|. .|.|                                              
degsdyinasyldlyy.ipdrfiatqgplrntladfwrmlkelgithivnltel..............................................

LKRVDGEESRELTHYWYKWPEAGVPaEEAPIIAMLLEARSSL--KSysleqanelreksatletsmdadgskaeagstssheingnissrsgtrsqQGPL
|.  ...|   ...... ||  |||   . .. .|   .. |  ..                                                  .|| 
lydpellerlgiqylylpwpDhgvp.llellleflefidellalsp..................................................ggpv

TVHCSPGTGRTGTIIASDMAIrsletpkRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASMY
 |||| | |||||..| .. .       ..... . | .||. |  |||...|| |.|. ....
lVHCsaGvgRtgtlvaaylml.......lglsleeavalvrekRpgavqnpsqyrflyyfekll
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1159-1258 1.3e-06 22.7 In-house 12-103 (130) alignment 
Range on Protein: 1159-1258
Range on HMM: 12-103/130.0
KTEYINANYVrGPRDAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDlsengIERCAEYLPPSATLDNHSSygDYQVTLKHREVKDRYAISTLVLK
  .||||..| |  .  . |.  |.||  |. |||.|. |.   |..         .|   || | |  |. .    |  ||| .|.  .    | |  .
gntyinasfv.Gllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgs.....veeedeywpdsePlewyee..diivtltdrdefknikasnleie
0051429 (Phosphotyrosine protein) phosphatases II 1160-1422 4.3e-32 107.2 In-house 4-228 (272) alignment 
Range on Protein: 1160-1422
Range on HMM: 4-228/272.0
TEYINANYVRGPrDA---PNYYIACQAPLESTTSDFWRMiWEQQSRVIIQATDLSENGIERCAEYLP--------PSATLDNHSSYGDYQVTLKHREVKD
. ||||..| |.      |........||. |  ||||. .|.. ..|.  ....| | . |  |.|           . .   .||.. ||| . |...
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

RYAISTLVLKRV-DGEESRELTHYWYK-WPEAGVPAEEapiIAMLLEARsslksysleqanelreksatletsmdadgskaeagstssheingnissrsg
 | . .|.|... . .|.||..|..|  ||  ||| |.   .  |||.                                                    
dyilrellltlllsagearevmhlhytdwpdhgvpqea...llellell...................................................

tRSqQGPLTVHCSPGTGRTGTIIASDMAIrSLETPKRSVD--------IPQLVYYVRRGRASAVQTKEQYEFIYKVASMYAAKI
 .. .||. |||| | .||||..| .. .    .    ||        . . | ..|. |. |||| |||.|.|...  .. ..
.ld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsl
0051082 (Phosphotyrosine protein) phosphatases II 1160-1414 1.7e-20 68.6 In-house 3-148 (151) alignment 
Range on Protein: 1160-1414
Range on HMM: 3-148/151.0
TEYINANYVRGPrdapnyYIACQAPlestTSDFWRMIWEQQSRVIIQATDLSENGieRCAEYLPPSAtldnhssygdyqvtlkhrevkdryaistlvlkr
. |||..|| |       ......|    ..||.....|.. ..|.  ... |.|   |.||||                                    
sdyinfsyvtgg......lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

vdgeesreLTHYWYKWPEAGVPAeeapiiamllearsslksysleqanelreksatletsmdadgskaeagstSSHEINGNISSRS---GtrSQQGPLTV
        ...... ..   .|                                                    .. ..  ..  .       ..||. |
........ievlhipildwpdpg..................................................lplsfdavleflellld..kkngpvlv

HCSPGTGRTGTIIASDMAIRSletpkrsVDIPQLVYYVRRGRASAVQTKEQYEFIYKV
||| | |||||..| .. ..        |.. . . ..|. |  .||...|. |....
HCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvqpnqqflfqlfa
0036282 (Phosphotyrosine protein) phosphatases II 1161-1415 1.4e-31 104.9 In-house 3-166 (174) alignment 
Range on Protein: 1161-1415
Range on HMM: 3-166/174.0
EYINANYVRGPRDAPnYYIACQAPLEsttsdFWRMIWEQQSRVIIQATDLSENGIERCAEYLPPsatldnhssygdyqvtlkhrevkdryaistlvlkRV
 ||||... . .  | ..||.|.||.     ||.|..|........ ... |.|...|  | |                                   . 
dyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................lr

DGEESRELTHYWYKWPEAGVPAEEApIIAMLLEARSSLksysleqanelreksatletsmdadgskaeagstssheingnissrsgTRSQQGPLTVHCSP
. .|   ...... ||  |||  .  .. .. .... |                                                 ....||. |||| 
edlerlgiqylylpwpDhgvpdlsi.llefvkfveeal................................................sedpggpvlVHCsa

GTGRTGTIIASDMAIRSLEtpKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVA
| |||||..| .. .| |.   . ||. .||. .|. |  .||| .||.|.|.. 
GvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrpgmvqtpsQyrflyyfe
0049260 (Phosphotyrosine protein) phosphatases II 1175-1292 2.3e-11 39.1 In-house 8-79 (152) alignment 
Range on Protein: 1175-1292
Range on HMM: 8-79/152.0
PNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLppsatldnhssygdyqvtlkhrevkdryaistlvlkrvdgeesrelTHYWYK
|...||.|.|.. |..|||||..|.. ..|.  |.|.|.| . |..|                                               ..... 
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..............................................qylhlp

WPEAGVPAEEAPIIAMLL
||  |||  .  .. .||
wpDhgvpdlsqlllflll
subfamily_hpo-7_pd Subfamily hpo-7 1175-1300 2.9e-07 24.6 In-house 37-156 (263) alignment 
Range on Protein: 1175-1300
Range on HMM: 37-156/263.0
PNYYIAcqapLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPpsATLDNHSSYGDYQVTLKHREVkdRYAISTLVLKR-VD-GEESRELTHYW
 | |.     |  |   |...|  ... |..  .|  |.|.|.| .|.|    .|.   . . .|.  .        . ||.|   ..   . ....|| 
knlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfP..lekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhys

YK-WPEAGVPAEEAPIIAMLLEARSSlKS
|| |.|   | .   |. .|  || | ||
ykgWiekndpelareilnilkvarns.ks
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1176-1258 2e-06 21.4 In-house 236-312 (440) alignment 
Range on Protein: 1176-1258
Range on HMM: 236-312/440.0
NYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENgieRCAEYLPPSAtldNHSSYGDYQVTLKHREVKDRYAISTLVLK
| .|| | ||.||  ||||.. . .   ||   .| ..    |. | |  .      ..| . |  |  |  .|  . || ||
nafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvnt...rsvtfgpftvghkgsenmnrvkvrtlelk
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1177-1304 6.2e-12 40.1 In-house 5-132 (198) alignment 
Range on Protein: 1177-1304
Range on HMM: 5-132/198.0
YYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPpsATLDNHSSYGDYQVTLKHREVKDRYAISTLVLKRV--DGEESRELTHYWY-
 |||.| ||  | .|||.|.||  |  |.   |   |     . | |  .|    . ||   || |   .|  |.|..|.|         .||..|| . 
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywp..ttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

KWPEAGVPAeEAPIIAMLLEARSSLKSYSLE
 | |   |   | .. ... .|   | |  |
swkekttpn.valfvgfvvasrevskkyeqe
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1177-1304 6.3e-12 40.1 In-house 6-133 (199) alignment 
Range on Protein: 1177-1304
Range on HMM: 6-133/199.0
YYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPpsATLDNHSSYGDYQVTLKHREVKDRYAISTLVLKRV--DGEESRELTHYWY-
 |||.| ||  | .|||.|.||  |  |.   |   |     . | |  .|    . ||   || |   .|  |.|..|.|         .||..|| . 
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywp..ttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

KWPEAGVPAeEAPIIAMLLEARSSLKSYSLE
 | |   |   | .. ... .|   | |  |
swkekttpn.valfvgfvvasrevskkyeqe
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1180-1300 5.3e-09 30.5 In-house 39-150 (255) alignment 
Range on Protein: 1180-1300
Range on HMM: 39-150/255.0
AcqaplesTTSDFWRMIWEQQSRVIIQATDLSENGIERCAEYLPpsATLDNHSSYGDYQVTLKHreVKDRYAISTLVLKRVDG--EESRELTHYWYK-WP
        |   |...|  ... |..  .|. |.|.|.| .|.|    .|..  . | .||  .        . ||..    |   . ....|| || |.
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfp..lekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWi

EAGVPAEEAPIIAMLLEARSSlKS
|   | .   |  .|  .| | ||
eknaPelareilnilkvvrds.ks
0048076 (Phosphotyrosine protein) phosphatases II 1257-1417 6.4e-15 50.6 In-house 37-141 (145) alignment 
Range on Protein: 1257-1417
Range on HMM: 37-141/145.0
LKRVDGEESRELTHYWYKWPEAGVPAEEAPIIAMLLEARSSLKSysleqanelreksatletsmdadgskaeagstssheingnissrsgtrsqQGPLTV
    ...|   ...... ||  |||   . ....|   .. ||.                                                   ||  |
tselellerlgiqylylpwpDhgvpdllellleflefieealke..................................................ggpvlV

HCSPGTGRTGTIIASDMAIRsletpkRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASM
||| | |||||..| .. ..      ..|.... . .||. |  ||.. .|..|.|..  .
HCsaGvgRtgtlvaaylmll......lgvsleealelvrsqrpgavpnpgqlrflyefele
0048179 (Phosphotyrosine protein) phosphatases II 1267-1414 7e-15 50.5 In-house 49-140 (144) alignment 
Range on Protein: 1267-1414
Range on HMM: 49-140/144.0
ELTHYWYKWPEAGVPaeeaPIIAMLLEARSSLKSYsleqanelreksatletsmdadgskaeagstssheingnissrsgtRSQQGPLTVHCSPGTGRTG
 ...... ||  |||    .....|||.   ....                                              ... ||  |||| | ||||
giqylhlpwpDhgvp....dllellleflefieea..............................................leeggpvlVHCsaGvgRtg

TIIASDMAIrsletpKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKV
|..| .. .      |. ... . ...||. |  ||.. .|..|... 
tlvaaylmk......klglsleealalvrsrrpgavpnpgqlrfLley
PTPc_DSPc_SM00012 1270-1415 2.7e-22 74.3 In-house 5-103 (105) alignment 
Range on Protein: 1270-1415
Range on HMM: 5-103/105.0
HYWYKWPEAGVPAEEAPIIAMLLEARSSLKSYSLeqanelreksatletsmdadgskaeagstssheingnissrsgtrsqQGPLTVHCSPGTGRTGTII
 ....||. ||| |  .|. .| . ... .  .                                                ..|. |||| | |||||..
yhytgwpdhgvPeesdsilellravkknknkses...............................................skpvvVhCsaGvgRtgtfv

ASDMAIRSLETPKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVA
| |.....||. ...||| |.| ..|. |...|||.||| |.|.. 
aldillqqleketkevdifqivkelrkqRpgmvqteeqylflyral
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1319-1423 3.9e-13 43.9 In-house 187-287 (290) alignment 
Range on Protein: 1319-1423
Range on HMM: 187-287/290.0
SMDADGsKAEAGSTSSHEINGNIssRSGTRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETpKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASMY
..| .| | .. .|. . |.  .  .   .. .... |||| . ||... .| ...|   .| .  .|. |...  |  .   |||..||..|...   |
nwdstg.kvtnpqtillvieemy..ktqrkrgntsivvHCSdtvgrsavfcaaattinkckt.egvidvfqvlksqRiqkpgsvqtvqqyqgifqivlty

AAKIT
  ...
ldsfe
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1335-1419 3.4e-10 34.2 In-house 246-344 (350) alignment 
Range on Protein: 1335-1419
Range on HMM: 246-344/350.0
HEINGNISSRSGTRSQQGPLTVHCSPGTGRTGTIIASDMAIR-------------SLETPKRSVD-IPQLVYYVRRGRASAVQTKEQYEFIYKVASMYA
. |. ...      ... |. |||| | |||||... |. .               |.....  | | ..|  .|. | | ||...|. |||. .  | 
dliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyf
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1339-1413 4.5e-11 37.4 In-house 160-233 (237) alignment 
Range on Protein: 1339-1413
Range on HMM: 160-233/237.0
GNISSRSGTRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLEtPKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYK
 ||  ||   |. ||  .||| | |||| ..  |  .|  .  |. ||| . || .   |   .|||.|| ||..
kniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak.ekkvvdiynyvysieedrpyiiqtkdqyvfihq
subfamily_PTPN9_pd Subfamily PTPN9 1340-1422 1.4e-16 55.4 In-house 212-293 (297) alignment 
Range on Protein: 1340-1422
Range on HMM: 212-293/297.0
NISSRSGTRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETpKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASMYAAKI
......  . .. |. |||| | ||||| |. |...  ||. .  ||. . | ..|  || ..|| ||||| |.    || . 
elgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrlee.vgtvdvvetvkllrtqrafsiqtpeqyefcylavleyalel
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1342-1418 9.3e-11 36.3 In-house 200-276 (307) alignment 
Range on Protein: 1342-1418
Range on HMM: 200-276/307.0
SSRSGTRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETPKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASMY
   . .| .. |. |||| | ||.|||.|  .    . . .   |. .||  .|  |  |.||. || ....|   |
nlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1344-1418 1.6e-16 55.3 In-house 206-279 (318) alignment 
Range on Protein: 1344-1418
Range on HMM: 206-279/318.0
RSGTRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETpKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASMY
.  ..|..||..|||| | ||||. || |. .. ..     ||. | |  .|. |   |||..||||||.|   .
kaqqksgagpivvhCsaGvGrtGvfiavdillerika.ealvDvfqtvkqlreqrnlmvqtedqyefiydvllea
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1344-1426 2.1e-16 54.9 In-house 168-249 (250) alignment 
Range on Protein: 1344-1426
Range on HMM: 168-249/250.0
RSGTRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETpKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASMYAAKITNLS
.|  .....|. |.|| |.||.|. || |  .  |.. .. ||. ...  .|. |  ||...||| |.|...  .   . ...
asqqqagnaPvivqCsaGvgrsGafiaidavlerlkk.ekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedya
subfamily_PTPN14_pd Subfamily PTPN14 1344-1417 2.7e-16 54.4 In-house 222-294 (300) alignment 
Range on Protein: 1344-1417
Range on HMM: 222-294/300.0
RSGTRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETPKrSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASM
 . ..... |. |||| | |||| .| ||. | .||. . ..||.. .  .|. | . |||  ||.|.|||   
eveskeskPPvlvhCsaGvGrtGvlilsdlliatlehne.eidikkvlarLreqrmllvqtlaqYkfvYkvlik
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1344-1418 7.4e-16 53.1 In-house 209-282 (319) alignment 
Range on Protein: 1344-1418
Range on HMM: 209-282/319.0
RSGTRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETpKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASMY
.|  ..|.||..|||| | ||||| |. |...  ..     .|. . |  .|  |   ||..|||.|||..   .
ksrektqsgPivvhCsaGvGRtGtfivldamlervke.egvlDvfstvsrlRtqRnimvqrpeqYkfiyeallea
subfamily_PTPRG_pd Subfamily PTPRG 1344-1426 2.9e-14 47.2 In-house 213-295 (563) alignment 
Range on Protein: 1344-1426
Range on HMM: 213-295/563.0
RSGTRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETpKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKV-ASMYAAKITNLS
   .... ||..|||| |.||||| |. |  .. ... . .|.. ...  .|  |   |||.||| |....  .. |.| |.|.
saankaeaGPivvHcsaGvgrtGtyivldtllkqiqq.enavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketell
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1344-1420 3e-12 41.1 In-house 204-279 (287) alignment 
Range on Protein: 1344-1420
Range on HMM: 204-279/287.0
RSGTRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETpKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASMYAA
..  .. .... |||| . ||... .| ...|.  .|    .|. |..   |  .  .||| |||.||...  .|  
ktqrkrgntsivvhCsdtvGrsamfcaaattinkckt.eGviDvfqvlksqriqkpgsvqtveqykfindivleyld
subfamily_PTPN12_pd Subfamily PTPN12 1345-1425 3.1e-19 64.0 In-house 201-284 (290) alignment 
Range on Protein: 1345-1425
Range on HMM: 201-284/290.0
SGTRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETPKR--SVDIPQLVYYVRRGRASAVQTKEQYEFIYK-VASMYAAKITNL
.  .|.. || |||| | |||||||| |.. . |.. |   ..|. .||  .|. ||..||||||||..|| ||..  ......
elqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkeleii
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1345-1418 4.7e-16 53.9 In-house 217-289 (298) alignment 
Range on Protein: 1345-1418
Range on HMM: 217-289/298.0
SGTRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETpKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASMY
| ... . |..|.|| |.||.|| || |  .  ... ...||. | | ..|. |. ||||.||| |||..   .
sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkk.eqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlea
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1345-1418 4.7e-12 40.2 In-house 215-288 (305) alignment 
Range on Protein: 1345-1418
Range on HMM: 215-288/305.0
SGTRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETPKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASMY
|  |  . |. |||| | ||||||.| .  .  .   |.   .|.||  .|  || ..|.  || ||..|   |
sairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1345-1414 1.5e-10 35.0 In-house 121-189 (440) alignment 
Range on Protein: 1345-1414
Range on HMM: 121-189/440.0
SGTRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETpKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKV
|  .. .||| |||| |.|||| ||| |  .|  .     .||  ..  .|  |   ||| ||| |....
sqekagngpllvhcsagagrtgviiavdsilreakr.sdqidifsfinsmrnnrpqmvqtpeqyafvhea
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1345-1415 1.7e-10 35.6 In-house 214-284 (325) alignment 
Range on Protein: 1345-1415
Range on HMM: 214-284/325.0
SGTR-SQQGPLTVHCSPGTGRTGTIIASDMAIRSLETpKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVA
  .     .|. |||| | ||||. |.   |.  . . . .||| . |  .|. | | |.| .|| .||.  
vtantkastpilvhcsaGvGrtGvfislysalakvie.esrvdifgfvkklrkdrpsmvetvdqyiliyeal
subfamily_PTPRB_pd Subfamily PTPRB 1346-1415 1.5e-15 52.0 In-house 213-281 (293) alignment 
Range on Protein: 1346-1415
Range on HMM: 213-281/293.0
GTRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETpKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVA
 . ....|..|||| | ||||| || |. ....|. .  |||  .|. .|. |.. |||..|| ||... 
ektaskrPivvhCsaGvGRtGtfialdrllqaiee.edyvdifgivaelReeRnllvqtekqYifihqcv
subfamily_Ptp69D_pd Subfamily Ptp69D 1346-1418 3.2e-14 47.8 In-house 214-285 (307) alignment 
Range on Protein: 1346-1418
Range on HMM: 214-285/307.0
GTRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETPKrSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASMY
  . ...|..|||| |.||.|...| |. .  |.. . .||| . |  .|. |   ||  |||.|.|.    |
lyklnrsPivvhCsaGvgrsgifvaldsllqqlkaed.kvdifetvkdLrsqRnllvqsleqYvflyralldy
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1346-1415 1.9e-13 45.0 In-house 194-262 (283) alignment 
Range on Protein: 1346-1415
Range on HMM: 194-262/283.0
GTRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETpKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVA
 |.|..||. |||| | |||.. ||   ..  . | .  ||... |  .|  |  ||||..|| ......
qteskkgPivvhCstgiGrtavfiaasasvkdalt.esvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_CG7180_pd Subfamily CG7180 1346-1418 4.4e-11 37.0 In-house 218-289 (296) alignment 
Range on Protein: 1346-1418
Range on HMM: 218-289/296.0
GTRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETpKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASMY
  . ..||. |..| |..|.|  .| |...  .|  .  ||. . |  .|| |   |...|.| .|| | . .
dedpeegPvvvvssdGasRsGvylaidanlelvek.eeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1347-1417 3.9e-16 54.0 In-house 204-274 (281) alignment 
Range on Protein: 1347-1417
Range on HMM: 204-274/281.0
TRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETPKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASM
..... || .||| | ||||| || | .....|. ....|. ..|  .|. |   |||  ||||.||.   
ekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavld
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1347-1418 9.6e-15 49.5 In-house 212-282 (305) alignment 
Range on Protein: 1347-1418
Range on HMM: 212-282/305.0
TRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETpKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASMY
 .... ||.|||| | ||||. || |.|.  |..   .||. ...  .|. |  .|||..|| |.. .   .
kkdkgvpllVhCsagvgRtGvfiavdialerlkk.EevvdvfevlkqlRskrmkmvqtldqYvflhdaldel
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1347-1413 3.4e-13 43.8 In-house 208-273 (439) alignment 
Range on Protein: 1347-1413
Range on HMM: 208-273/439.0
TRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETPKRsVDIPQLVYYVRRGRASAVQTKEQYEFIYK
 . . ||. |||| | |||||||| |.|.  | . .. |||  .| ..|. |   ||.  || |||.
dkeeygpvvvhcsagvGrtGtiialdialeqlklenk.vdikgivkvlrkqrkqmvqalcqyvfiyn
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1347-1416 3e-12 40.8 In-house 196-266 (281) alignment 
Range on Protein: 1347-1416
Range on HMM: 196-266/281.0
TRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETPKRSVDIPQLVYYVR-RGRASAVQTKEQYEFIYKVAS
 |..  |  .||| | ||.||..| ..|..|. .     || |.| ..|  |||..||| .|| .|.||  
irarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvll
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1347-1421 5.4e-10 33.5 In-house 215-289 (305) alignment 
Range on Protein: 1347-1421
Range on HMM: 215-289/305.0
TRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETPKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASMYAAK
.|. .||..|||| | ||||...  .  .  | . .   |  ...  .|  |  ..|| .|| |...|   |  |
arpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1347-1426 3.4e-07 24.1 In-house 219-297 (310) alignment 
Range on Protein: 1347-1426
Range on HMM: 219-297/310.0
TRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETPKrSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASMYAAKITNLS
.. ..||  |||| | .|.....| ...|  |.  .  ||. ...  ... ||  .||. || .| .|  ..|   |. .
aqvrhgpcvvhcsagkdrlyvvvalklkidkldrgl.kvdaeevktellksraiciqtelqyliidrvriifargeteva
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1347-1414 4.6e-07 23.8 In-house 205-271 (312) alignment 
Range on Protein: 1347-1414
Range on HMM: 205-271/312.0
TRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETPKRSvDIPQLVYYVRRGRASAVQTKEQYEFIYKV
 . .. |.  ||| | |||||..  .  | .|  |..  .. .    .|. || .|..  || .  ..
vkkdkkpviahcsagvgrtgtlaliesmiaalrhprkq.nvkdsfvllrkdrarsvrvfpqyvyalrc
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1348-1421 2.2e-19 64.5 In-house 194-266 (270) alignment 
Range on Protein: 1348-1421
Range on HMM: 194-266/270.0
RSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETPKrSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASMYAAK
 ....|| |||| | |||||.|| |.|.| ||. | .||. ...  .|. |   ||. |||||.||. ..|| .
ldkaePllvHcsaGvgRtGtlialDiavrlLeetk.kvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_PTPN6_pd Subfamily PTPN6 1348-1421 8.1e-18 59.4 In-house 224-299 (306) alignment 
Range on Protein: 1348-1421
Range on HMM: 224-299/306.0
RSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETPK--RSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASMYAAK
....||. |||| | |||||.|  |. .. .|. .    .|| .|| .||. |   |||..|| |.||. ..|  .
eaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1348-1416 2.1e-17 58.1 In-house 209-276 (288) alignment 
Range on Protein: 1348-1416
Range on HMM: 209-276/288.0
RSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETpKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVAS
 ...||..|||| | ||||| || |..|  .|. .  .|.   |  .|. ||. |||..||||||.|  
qadtgpiivhCsaGvGrtgtFialdalidavee.edyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_PTPN13_pd Subfamily PTPN13 1348-1415 1.8e-15 51.9 In-house 199-265 (273) alignment 
Range on Protein: 1348-1415
Range on HMM: 199-265/273.0
RSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETPKrSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVA
....||. |||| | ||.||.|. |...  .|  | ..|. ..|  .|. | . ||||.|| |.||..
qtdagPivvhcsaGiGrsGtlitidvvlglierdk.efdvkeivrklreqrqgvvqtkdqyifvykai
0049260 (Phosphotyrosine protein) phosphatases II 1348-1416 4e-15 51.3 In-house 86-147 (152) alignment 
Range on Protein: 1348-1416
Range on HMM: 86-147/152.0
RSQQGPLTVHCSPGTGRTGTIIASDMAIrsletpkRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVAS
....||  |||| | |||||..| .. .       . |.. . | .||. |  ||....|..|.|....
ldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrflyefek
0046846 (Phosphotyrosine protein) phosphatases II 1348-1418 1.4e-14 49.7 In-house 106-172 (176) alignment 
Range on Protein: 1348-1418
Range on HMM: 106-172/176.0
RSQQGPLTVHCSPGTGRTGTIIASDMAIRsletpKRSVDIPQLVYYVRRGRA-SAVQTKEQYEFIYKVASMY
... ||  |||| | |||||..| .. ..     .. ... . ...||. |   |||| |||.|.|... ..
lkeggpvlVHCsaGigRtgtlvaayllel.....ekglsveealalvreqRplgavqtpeQyrflyefelll
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1348-1416 3.3e-14 47.4 In-house 207-274 (315) alignment 
Range on Protein: 1348-1416
Range on HMM: 207-274/315.0
RSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETpKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVAS
.... .| |||| |.|||| .|. |  .  ..  .||||. ..|  .|. |   |||.|.| ||| .  
gkkefsllvhcsaGvGrtGvvisidevvaqikr.trsvdvfnfvknlrakrpylvqteeeyafiydavl
subfamily_PTPRK_pd Subfamily PTPRK 1348-1415 4e-13 43.9 In-house 207-273 (314) alignment 
Range on Protein: 1348-1415
Range on HMM: 207-273/314.0
RSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETpKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVA
  ..|.. |||| |.||||| || |. .  .|. .. ||. . |  .|  .   |.|.||| ||| |.
eeeaGrivvhCsaGaGrtGtfiaidivldmier.egvvdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_PTPRN_pd Subfamily PTPRN 1348-1414 8.5e-12 39.4 In-house 221-287 (297) alignment 
Range on Protein: 1348-1414
Range on HMM: 221-287/297.0
RSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETPKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKV
| .  |. |||| |.||||. |. |. .  |    . .||   . ..|  |.  |.||.|.||....
rGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalta
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1348-1412 2e-10 34.8 In-house 213-276 (290) alignment 
Range on Protein: 1348-1412
Range on HMM: 213-276/290.0
RSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETPKrSVDIPQLVYYVRRGRASAVQTKEQYEFIY
|   ||..|||| | |||||..| ..... |   | ..|. .||  .|. |...||   ||  . 
rkasGpvvvhcsaGiGrtGtfvaievglqilldGk.eldlldlvralrnsrlnsvqvdiqylalv
subfamily_PTPN1_pd Subfamily PTPN1 1348-1413 3e-10 34.3 In-house 198-265 (290) alignment 
Range on Protein: 1348-1413
Range on HMM: 198-265/290.0
RSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETPKR--SVDIPQLVYYVRRGRASAVQTKEQYEFIYK
 |..||  .||| | ||.||..  |  .  .|  .   |||| . .  .|. |   .||..| .| | 
ssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsyl
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1348-1418 6.9e-10 33.4 In-house 201-270 (288) alignment 
Range on Protein: 1348-1418
Range on HMM: 201-270/288.0
RSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETPKrSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASMY
.| | |. ||.| |.|||||.| . .|..||  .   . |..|.   |  |  |.||. || .....   .
kslqkPivvhssaGvGrtgtlililialeslrldd.flgirsllaklreerfkaiqtemqylyvhrcvlee
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1348-1414 3.6e-09 31.1 In-house 132-199 (199) alignment 
Range on Protein: 1348-1414
Range on HMM: 132-199/199.0
RSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETPKRS-VDIPQLVYYVRRGRASAVQTKEQYEFIYKV
. .. |. |||| | | || ..| |. .|| |  | | ||. ..   .|. |   . . ..|.|||.|
qekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1348-1414 3.6e-09 31.1 In-house 131-198 (198) alignment 
Range on Protein: 1348-1414
Range on HMM: 131-198/198.0
RSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETPKRS-VDIPQLVYYVRRGRASAVQTKEQYEFIYKV
. .. |. |||| | | || ..| |. .|| |  | | ||. ..   .|. |   . . ..|.|||.|
qekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_egg_pd Subfamily egg 1348-1419 1.1e-06 22.6 In-house 198-270 (307) alignment 
Range on Protein: 1348-1419
Range on HMM: 198-270/307.0
RSQQGPLTVHCSPGTGRTGTIIASDMAIRSL-ETPKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASMYA
|    |  |..  |  ...|..| ..|. ||   |     . . | ..|. |  .|..  .| |.|..  .. 
rnlskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff
0038934 (Phosphotyrosine protein) phosphatases II 1348-1415 4.2e-06 22.0 In-house 112-173 (194) alignment 
Range on Protein: 1348-1415
Range on HMM: 112-173/194.0
RSQQGPLTVHCSPGTGRTGTIIASDMAIRsletpkRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVA
....|   |||  | |||||..|. .  |      .  .  . ....|. | .|... ...| ..|  
edpggvvaVHCkaGlgRtGtlvaaYLiyr......lgmsaeeAialfrekRpgaipnqdyleallkry
subfamily_PTPRA_pd Subfamily PTPRA 1349-1418 3.3e-16 54.1 In-house 226-294 (330) alignment 
Range on Protein: 1349-1418
Range on HMM: 226-294/330.0
SQQGPLTVHCSPGTGRTGTIIASDMAIRSLETpKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASMY
 . ||..|||| |.||||| |. |  .  ... .| ||. . |  .|  |.  |||.|||||||||   |
qsagpivvhcsaGvGrtGtfivldavlervka.erkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1349-1415 1.2e-14 49.1 In-house 215-280 (297) alignment 
Range on Protein: 1349-1415
Range on HMM: 215-280/297.0
SQQGPLTVHCSPGTGRTGTIIASDMAIRSLETpKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVA
 ..||| |||. | |||| ... |  .   .  . .||| .||  .|. |   |||||||.|.|.. 
naegPllvhclaGvGrtgvlltidsvvaeakr.ekevdifglvkklrqerpylvqtkeqykfvyvav
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1349-1418 5.8e-10 33.4 In-house 208-276 (287) alignment 
Range on Protein: 1349-1418
Range on HMM: 208-276/287.0
SQQGPLTVHCSPGTGRTGTIIASDMAIRSLETpKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASMY
|. ||| ||.. | ||.|...|  . .. ||     ||. . | ..|  ||. ||.  |. ..|.    |
sevGPlvvhddvGiGrsGillatlvlvsrled.lGrvdvaavvirlreyraalvqavvqlrllyealvty
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1350-1415 1.3e-12 42.3 In-house 211-275 (315) alignment 
Range on Protein: 1350-1415
Range on HMM: 211-275/315.0
QQGPLTVHCSPGTGRTGTIIASDMAIRSLETpKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVA
. |.. |||| | ||||| |. |  .  .|. .. .|. ...  ||. |  .||. |||.|||.. 
svgaivvhcsaGvGrtGtfitldavldqaea.enaidvynfitgvrqnrikmvqvaeqyqfiydal
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1350-1415 5.8e-11 36.8 In-house 227-291 (297) alignment 
Range on Protein: 1350-1415
Range on HMM: 227-291/297.0
QQGPLTVHCSPGTGRTGTIIASDmAIRSLETPKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVA
.. .| |||| | ||.| .. || .| .    ||  |.  .. ..|  ||  ||| ||.|..|...
rnayllvhcsaGvGrsGvvvlsd.vilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1350-1420 1.7e-10 35.4 In-house 191-260 (267) alignment 
Range on Protein: 1350-1420
Range on HMM: 191-260/267.0
QQGPLTVHCSPGTGRTGTIIASDMAIRSLETPKrSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASMYAA
 . || |.|| | ||.|| .  |  .. . |    .|| ...  .|  | . |.|||.| .|... . || 
gnrPlvvacsdGvGrsGtflvidsqlerakteg.vsdifdflrkirsqriglvdtkeryiyihellaeyae
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1350-1413 2.4e-10 35.2 In-house 223-285 (319) alignment 
Range on Protein: 1350-1413
Range on HMM: 223-285/319.0
QQGPLTVHCSPGTGRTGTIIASDMAIRSLETpKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYK
.. .. |||| |.||||. |. |. .  ..  .. ||. ..|  .|. |   ||   || ||| 
hranivvhcsaGvGrtGvyivldvlldrmke.ekqvdvynfvrdlrqqrntlvqdlvqykfiys
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1350-1413 3.3e-10 34.9 In-house 187-249 (284) alignment 
Range on Protein: 1350-1413
Range on HMM: 187-249/284.0
QQGPLTVHCSPGTGRTGTIIASDMAIRSLETpKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYK
.. .. |||| |.||||. |. |. .  ..  .. ||. ..|  .|. | . ||   || ||| 
hranivvhcsagvgrtgvyivldvlldrmke.ekqvdvynfvrdlrqqrntlvqdlvqykfiys
subfamily_PTPDC1_pd Subfamily PTPDC1 1350-1415 6.4e-08 27.2 In-house 113-172 (182) alignment 
Range on Protein: 1350-1415
Range on HMM: 113-172/182.0
QQGPLTVHCSPGTGRTGTIIASDMAIRSLETPKRSvdipqlVYYVRRGRASAVQTKEQYEFIYKVA
|.| ..|||  | |||| .||. .   .  |....      .  ||  |....||.|| |.. . |
qegkvavhChaGlGrtGvliacylvyakrltaeka......iklvrskrpksiqtreqvelvkefa
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1350-1423 1e-07 26.4 In-house 190-263 (290) alignment 
Range on Protein: 1350-1423
Range on HMM: 190-263/290.0
QQGPLTVHCSPGTGRTGTIIASDMAIRSLETPKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASMYAAKIT
.. |  |||  |  |  .. |....   .   . || . ......|. || |....... |.  .. ..| ...
sktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaievl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1350-1418 1.3e-07 25.9 In-house 202-269 (285) alignment 
Range on Protein: 1350-1418
Range on HMM: 202-269/285.0
QQGPLTVHCSPGTGRTGTIIASDMA-IRSLETPKrsVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASMY
.. |. |||| | ||| |..  | | || .| |.  ... ..|  .|  |  |||.. |. |.| |   |
kekpicvhcsagvgrtatfvgidyatirimenpn..iemldivremramrfqavqshmqflflyvvlmey
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1351-1415 1.9e-14 47.7 In-house 209-272 (515) alignment 
Range on Protein: 1351-1415
Range on HMM: 209-272/515.0
QGPLTVHCSPGTGRTGTIIASDMAIRSLETpKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVA
. || .||| | |||| .|. |  .   .|  |.||. ..|  .|. |   |||.||| ||| . 
thpliihcsaGvGrtGvvisidsvvahakt.trmvdvfnfvtnirqkrpylvqtqeqyafiygav
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1351-1413 3e-11 37.4 In-house 169-230 (392) alignment 
Range on Protein: 1351-1413
Range on HMM: 169-230/392.0
QGPLTVHCSPGTGRTGTIIASDMAIRSLETpKRSVDIPQLVYYVRRGRASAVQTKEQYEFIYK
  || .||| | |||| .|. |  .   ..  | ||. ..|  .|| |   ||||||| ||| 
thpliihcsagvgrtgvvisidsvvahakk.trmvdvfnfvtnirrkrpymvqtkeqyafiyg
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1351-1418 2.8e-06 21.3 In-house 214-279 (301) alignment 
Range on Protein: 1351-1418
Range on HMM: 214-279/301.0
QGPLTVHCSPGTGRTGTIIASDMAIRSLETpKRSVDIPQLVYYVRRGRASAVQTKEQYEFIyKVASMY
. |. |||| | ||. . |....  | .|. .. ... . .  .|  | ..|||..|  .. .. ..|
ekPivvhcsaGiGrsvafigteylarevea.dptieltealkhlrehrwngvqtnsqlywm.tlGtvy
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1352-1412 5.8e-09 30.5 In-house 174-233 (239) alignment 
Range on Protein: 1352-1412
Range on HMM: 174-233/239.0
GPLTVHCSPGTGRTGTIIASDMAIRSLETpKRSVDIPQLVYYVRRGRASAVQTKEQYEFIY
 |  .||| | ||||...  |  .|  .  ...||| . |  .|  |   ||| ||| ||.
rpwvihcsagvgrtgaflvidamlrqakk.qktvdifnyvkairedrphmvqtseqyvfih
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1352-1412 6.1e-09 30.4 In-house 175-234 (239) alignment 
Range on Protein: 1352-1412
Range on HMM: 175-234/239.0
GPLTVHCSPGTGRTGTIIASDMAIRSLETpKRSVDIPQLVYYVRRGRASAVQTKEQYEFIY
 |  .||| | ||||...  |  .|  .  ...||| . |  .|  |   ||| ||| ||.
rpwvihcsagvgrtgaflvidamlrqakk.qktvdifnyvkairedrphmvqtseqyvfih
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1354-1411 8.6e-09 29.3 In-house 224-280 (302) alignment 
Range on Protein: 1354-1411
Range on HMM: 224-280/302.0
LTVHCSPGTGRTGTIIASDMAIRsLETPKRSVDIPQLVYYVRRGRASAVQTKEQYEFI
. |||| | |||||..|    |  | . |.  |. ..|  ||. |  |||...|  ..
vlvhcsaGvGrtGtlvaikyGiq.lcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1355-1413 1.4e-08 29.0 In-house 2-59 (69) alignment 
Range on Protein: 1355-1413
Range on HMM: 2-59/69.0
TVHCSPGTGRTGTIIASDMAIRSLETPKrSVDIPQLVYYVRRGRASAVQTKEQYEFIYK
 |||| |||||||.||  . .  . . |  |||   | |.|. |   |  . .| ||. 
vvhcssgtgrtgtfiaimvemariksek.lvdifnnvqymrkcrpmmvmneieyifihd
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1356-1413 9.8e-09 29.4 In-house 2-58 (69) alignment 
Range on Protein: 1356-1413
Range on HMM: 2-58/69.0
VHCSPGTGRTGTIIASDMAIRSLETPKrSVDIPQLVYYVRRGRASAVQTKEQYEFIYK
|||| ||||||| ||  . .  . . |  |||   | |.|. |   |  ...| ||. 
vhcssGtGrtGtfiaimvemariksek.lvdifnnvqymrkcrpmmvmneneymfihd
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1356-1421 2.6e-08 27.6 In-house 223-287 (302) alignment 
Range on Protein: 1356-1421
Range on HMM: 223-287/302.0
VHCSPGTGRTGTIIASDMAIRSLETPkRSVDIPQLVYYVRRGRASAVQTKEQYEFIYKVASMYAAK
.    |.|| |....  .|. .|..    . | ..|  .|  |..||.. .|| ..| .. .|  |
ivSknGaGRagafltlavaveklqkg.kepnikeivksiRsqRpravdslkQyvslyialllyikk