Gene Ptp4E in Drosophila melanogaster

Synonym: 4E, CG6899, CT21187, DPTP4E, Dmel\CG6899, PTP4E, PtP4E, R-PTP 4E, Dmel_CG6899, Ptp4E

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRB
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP048_AA protein Get Run
DmelP048_AA_1311-1586 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
fn3 Fibronectin type III domain 152-230 1.1e-09 31.5 Pfam-A 1-80 (85) alignment 
Range on Protein: 152-230
Range on HMM: 1-80/85.0
DPPANLSVQLRSSKSAFITWRPP--GSGRYSGFRIRVLGLTDLPFERSYSLEGNETlQLSAKELTPGGSYQVQAYSVYQGK
..| ||||  ..| |. ..| ||  |.| ..|.....   ..   ..........| ..  ..|.|| .|... ..| .. 
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngag
fn3 Fibronectin type III domain 247-326 2e-12 40.3 Pfam-A 3-80 (85) alignment 
Range on Protein: 247-326
Range on HMM: 3-80/85.0
PGKFIVWFRNETTLLVLWQPPF-PAGIYTHYRVSITPDDAIQsvlyVEREGEPPGPA-QAAFKGLVPGREYNISVQTVSEDE
|. . |  ...|.| . |.||. . | .|.|.|   ...  .    ...|   |... .. ..|| ||.||...||.|... 
PenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge....ewkeftvprtttsvtltgLkpgteYefrVqavngag
Big_5 Bacterial Ig-like domain 328-422 6.4e-06 14.8 Pfam-A 9-92 (107) alignment 
Range on Protein: 328-422
Range on HMM: 9-92/107.0
SSVPTTARYLTVPERVLNVTFDEAYTTSSS-FRVRW-EpprtyseFDAYQVMLSTSrrifnvprAANGDSVYFDYPDILEPGRTYEVVV-KTIADNV-N
|..|..      ..  . .||.|. ...|    .            |. .| ...|         ..|..|...  . |....||.|.| ... |.  |
stsPadgatnvavnaeititFsepvdaasvtaaivial.......sdsatvavtgs........svagktvtitptaaLaanttYtvtvtagvkDlagn
fn3 Fibronectin type III domain 343-419 1.9e-06 21.1 Pfam-A 3-78 (85) alignment 
Range on Protein: 343-419
Range on HMM: 3-78/85.0
VLNVTFDEAytTSSSFRVRWEPPR-TYSEFDAYQVMLSTSRRIF-NVPRAANGDSVYFDYPDiLEPGRTYEVVVKTIAD
. |....|   ||.|....|.||.   .... |.| .....     . . . ...  .  .. |.||..||. |... .
Penlsvsev..tstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltg.LkpgteYefrVqavng
fn3 Fibronectin type III domain 445-519 8.2e-11 35.1 Pfam-A 10-79 (85) alignment 
Range on Protein: 445-519
Range on HMM: 10-79/85.0
DDRSNALHISWEPAE--TGRQDSYRISYHEQTNASevpapfpVAAESQITTNLTEYTLDSLLAGRRYLIAVQALSKG
. .|. |..||.| .   |  ..|.. | |... .       .  | ... . |..||  | .|..| . |||....
evtstsltlsWsppkdgggpitgYeveyrekggge.......ewkeftvprtttsvtltgLkpgteYefrVqavnga
fn3 Fibronectin type III domain 547-607 1e-09 31.6 Pfam-A 15-80 (85) alignment 
Range on Protein: 547-607
Range on HMM: 15-80/85.0
GLMLSWRSD--VNSRQDRYEVHYQRNGTRE---ERTMATNETSLTIHYLHPGSGYEVKVHAISHGV
 |.|||      ..  ..|||.|.  |. |   |.|   ..||.|.. | ||. ||..|.|.. . 
sltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngag
fn3 Fibronectin type III domain 622-694 1.1e-10 34.6 Pfam-A 2-79 (85) alignment 
Range on Protein: 622-694
Range on HMM: 2-79/85.0
PPQNLTLQTVHTNLVVLHWQAPE--GSDFSEYVVRYRTDASP--WQRISgLHEN--EARIKDMHYGERYLVQVNTVSFG
.|.||..  | .. ..|.|..|.  |.... | |.||.. ..  |.... . ..  .. ....  | .| ..| .|. .
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeft.vprtttsvtltgLkpgteYefrVqavnga
fn3 Fibronectin type III domain 719-790 2.6e-12 39.9 Pfam-A 11-79 (85) alignment 
Range on Protein: 719-790
Range on HMM: 11-79/85.0
VDSRNLTLEWPRP---DGHVDFYTLKWWPTDEEDrvefknVTQLEDLSSPSVRIPIEDLSPGRQYRFEVQASSNG
| |..|||.|  |   .|... |...........      ...  ...... .  ...| ||..|.|.||| ...
vtstsltlsWsppkdgggpitgYeveyrekggge......ewkeftvprtttsvtltgLkpgteYefrVqavnga
fn3 Fibronectin type III domain 821-886 7.9e-07 22.3 Pfam-A 12-79 (85) alignment 
Range on Protein: 821-886
Range on HMM: 12-79/85.0
QDETITLSYTPT---PADSTRFDIYRFSMGDPTiKDKEKLANDTERKLSFSGLTPGKLYNVTVWTVSGG
.. ..||| .|     .. |....   ..|..  ..||. .  |.. . ..||.||. |...| .|.|.
tstsltlsWsppkdgggpitgYeveyrekggge.ewkeftvprtttsvtltgLkpgteYefrVqavnga
fn3 Fibronectin type III domain 902-975 3.3e-15 49.2 Pfam-A 2-79 (85) alignment 
Range on Protein: 902-975
Range on HMM: 2-79/85.0
PISDLKAIQVAAREITLHWTAP---AGEYTDFELQYLSADEEAPQLLQNVTKNT-EITLQGLRPYHNYTFTVVVRSGS
....|....| ....||.|..|    |..| .|..| ..... .   ..|...| . ||.||.|. .|.|.|  ..| 
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavnga
fn3 Fibronectin type III domain 1013-1092 1.6e-12 40.5 Pfam-A 6-84 (85) alignment 
Range on Protein: 1013-1092
Range on HMM: 6-84/85.0
FQPSDVQPGEVTFEWSLEPaEQHGPIDYFRITCQNADDAADVSSYEFPVNATQGKIDGLVPGNHYIFRIQAKSALGYGAE
.. |.|.. ..|..||  . ...|||............  .  ..  | ..|. .. || || .| ||.|| .. |.| |
lsvsevtstsltlsWsppk.dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
DUF1049 Protein of unknown function (DUF1049) 1253-1298 2.4e-06 14.5 Pfam-A 22-67 (68) alignment 
Range on Protein: 1253-1298
Range on HMM: 22-67/68.0
TVIVAATVSAVLLVAMVLVVVYCQHRCQLIRRASKLARMQDELAAL
.....| .  .||.....|... ..| || |  ..|.... ||..|
lllliafllGallglLlsvlfllklrrqlrrlqkqlkklekeldql
0050432 (Phosphotyrosine protein) phosphatases II 1296-1587 1.9e-98 324.9 In-house 13-301 (308) alignment 
Range on Protein: 1296-1587
Range on HMM: 13-301/308.0
AALPEGYITPNRPVHVKDFSEHYriMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLqpvddDDGSDYINANYMPGH--N
.  .... . . ...|.|. ...  ..|..  ...|||||| .|  .  .|.|.||.|..|||...|||||||| ||     |.|||||||.|..|.  .
lfrdtsilvsslklsvldllkll..ekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssk

SPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVD--RVAMFYGDIKVQLIIDTHYHDWSISEFMVSR--NCESRIMRHFHFT
.||.||.|||||..| | ||||.|| |.| |||||...|.|||||.|||| .  .  . ||...| |.  ....|. . .....   . |||...|||.|
lprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhyt

TWPDFGVPEPPQSLVRFVRAFRDVIGTdmRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLEG
.|||.|||. |..|..|... |....    ||.|||||||||.||||||| .|....|   ||.|..|  .|. | .||||..||. ....||  |. 
nWpdhgvPpspeilldflelvrkslpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
0039614 (Phosphotyrosine protein) phosphatases II 1304-1585 3.7e-91 300.9 In-house 9-289 (297) alignment 
Range on Protein: 1304-1585
Range on HMM: 9-289/297.0
TPNRPVHVKDFSEHYRIMSADSDFRFSEEFEELKHVGRDqaCSFANLPCNRPKNRFTNILPYDHSRFKLQPVDD-DDGSDYINANYMPGHNS-PREFIVT
... |.... .  ..... |.|  .. .|||||. .  |  .|.|.||.|..|||...|||||||| ||.|.|. | .||||||.|..|..  .|.||.|
lesipiplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIat

QGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGReKCDQYWPVDRVamFYGDIKVQLIIDTHYHDWSISEFMVSRNCESRIMRHFHFTTWPDFGVPEPPQ
||||..| | ||||.|| ....|||||...|.|| ||.|||| .     |||..| |.  .|.... . .. |..| |||...||..| |||.|||. ..
qgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppsle

SLVRFVRAFRDVIGT--DMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVL
.| .|... |... .  . .|..|||||||||.|||||....|....|   ||.. .|  .|. |  .|||..||. ....||  |
llleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
subfamily_PTPRB_pd Subfamily PTPRB 1306-1589 1.4e-138 455.9 In-house 4-289 (293) alignment 
Range on Protein: 1306-1589
Range on HMM: 4-289/293.0
NRPVHVKDFSEHYRIMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPL
..|.....|.||.. |.||||.|||||.||||.||.|||...|.|..|| |||.||||||||||.||....|..|||||||||.||.|||||||.|||||
skpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPl

HSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMVSRNCESRIMRHFHFTTWPDFGVPEPPQSLVR
..|...||||.||..|..|||||...|||..||..||| |. ...||||||.|. .....|| | |...... |.| .|..|||.|||.|||| ...|..
petvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktlld

FVRAFRDVI--GTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLEGKE
|||..|..|   ...|||.|||||||||.||||||||.||.|...||||||||| ..|.||...||||.||..||||.|..|. ||
fvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkke
0051299 (Phosphotyrosine protein) phosphatases II 1306-1584 2e-100 331.2 In-house 2-285 (288) alignment 
Range on Protein: 1306-1584
Range on HMM: 2-285/288.0
NRPVHVKDFSEHYRIMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPL
.....|... .... . |..  .. |||||| ..  |  .|.|.||.|..|||...|||||||| ||...|...|||||||.|..|.|..|.||.|||||
dteisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPl

HSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVdRVAMFYGDIKVQLIIDTHYHDWSISEFMVS------RNCESRIMRHFHFTTWPDFGVPEP
..| |.||||.|| |.| |||||...|.|||||.||||  .  . ||||.| |.  ....|. . ...|.       . |||. .|||.|.|||.|||. 
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpds

PQSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAV
|..|..|.|..|...  .  |..|||||||||.||||||| .|....|   ||....|  .|. | .||||..||. ....||  
pellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
0045450 (Phosphotyrosine protein) phosphatases II 1306-1585 1.2e-89 296.3 In-house 6-304 (307) alignment 
Range on Protein: 1306-1585
Range on HMM: 6-304/307.0
NRPVHVKDFSEHYRIMSADSDFRFSEEFEELKHVGR--DQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDD-DGSDYINANYM--------PGHNS
.... ....  ..... .|.  .. .|||.|..|       .|.|.||.|..|||...||||||.| ||...|.. ..||||||.|.        .|...
slfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl

PREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMVS---RNCESRIMRHFHFTTW
.|.||.|||||..| |.||||.|| ....|||||...|.|||||.|||| ..  . ||...| |.  .|.... .  . |.    . |||. .|||.|.|
krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgw

PDFGVPEPPQSLVRFVRAFRDVIGT--DMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDY---VDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVL
||.|||. ...|..|... |.....  .  |..|||||||||.|||||.. .|....|      ||.. .|  .|. |  .||...||. ....||  |
pdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1306-1589 3e-82 271.2 In-house 2-287 (319) alignment 
Range on Protein: 1306-1589
Range on HMM: 2-287/319.0
NRPVHVKDFSEHYRIMSADSDFRFSEEFEELKHVGRDqACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPL
.....|... |..... . ..  . .||..||. . |   . |. . |..|||..|||.||..| .|...|. .|||||||... |..  ..|| ||.||
dteievqeLkerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPl

HSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVaMFYGDIKVQLIIDTHYHDWSISEFMV---SRNCESRIMRHFHFTTWPDFGVPEPPQS
. | |.|||| || .|  .||||.  ||.. |. .|||   . . || . |.|  . . .|. |.....   | . |.| . ||..| ||| .|||  .|
entiedfWrmvWeeessivvmltklveklkvklkkywpeenf.eeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekats

LVRFVRAFRDVIG-TDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLEGKE
|. ...  |     |. .||.||||||||| ||||.|| .|.....   .|.| .|  .|  | .|||...||  |.. ||...|  .
lldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1306-1394 3.9e-11 36.9 In-house 3-88 (440) alignment 
Range on Protein: 1306-1394
Range on HMM: 3-88/440.0
NRPVHVKDFSEHYRimSADSDFRFSEEFEeLKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNS
.||. | ||... .  .      | .|.  |   |  | .  |.|| |. |||. ||| |||||  |. |     |||||| |. | .|
qrpiivadfadyvq..nnrrsrafedews.llpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingies
subfamily_PTPRD_pd Subfamily PTPRD 1307-1589 1.4e-112 372.2 In-house 3-286 (564) alignment 
Range on Protein: 1307-1589
Range on HMM: 3-286/564.0
RPVHVKDFSEHYRIMSADSDFRFSEEFEELKHVgRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLH
.|..|... ||.. . |.||..|.||......  .   .. || |.|..|||. ||..||||| .|..|. |.|||||||... |.......| |||||.
kpipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

STREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRvAMFYGDIKVQLIIDTHYHDWSISEFMV--SRNCESRIMRHFHFTTWPDFGVPEPPQSLV
.| |.||||.|| ||. |||||.. |||..||..||| ..    ||...|.|   ... | .| .| .  ... |||  |.|||| ||| |||| ..||.
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslL

RFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLE-GKE
...|  |..  .|  ||.|||||||||.||||..| .|. |.... |||...| |.||.| .|||||.||. ||. .|  |. |..
dlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnt
subfamily_PTPRA_pd Subfamily PTPRA 1307-1606 3.7e-85 280.7 In-house 12-317 (330) alignment 
Range on Protein: 1307-1606
Range on HMM: 12-317/330.0
RPVHVKDFSEHYRIMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLH
 |. |... |  || |||   .| |||. |     . ..  |.   |. |||. ||||||.||  |....  . |||||| .. |..   .|| .|||..
fplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPke

STREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRvAMFYGDIKVQLIIDTHYHDWSISEFMVS---RNC---ESRIMRHFHFTTWPDFGVPEPP
 | |.|||| || .| .|||||   |. .||| |||| .  .. ||.|.|..  .|   |... .|.|     ..   .||..| ||||.|||.|||  |
etvedfwrmiweqksativmltelkerkeekcaqywPdeG.lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfep

QSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAV-LEGKEHLLADSLELH
. ....... . .      ||.|||||||||.||||.|| .|. ..    ||.|..|  .|. |  ||||..||. |.. ||   | |   | . ||| |
iGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekh

ANDGYEV
 .  |. 
lqklynk
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1307-1583 1.7e-72 239.4 In-house 9-289 (319) alignment 
Range on Protein: 1307-1583
Range on HMM: 9-289/319.0
RPVHVKDFSEHYRIMSADSDF-----RFSEEFEELKHVGRDQA-CSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIV
  | |.||  .|. .|  |||     ..  ||  . ..| . |  .||||. |. |||..|||..|... ||....  ..|||||| .. |. ..  .| 
sdvavpdfpayyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyia

TQGPLHSTREEFWRMCWESNSRAIVMLTrcfekgREKCDQYWPVDRVAMfYGDIKVQLIIDTHYHDWSISEFMVSR---NCESRIMRHFHFTTWPDFGVP
.||||  | ..|||| ||.|. .||.||      ..|| |||| . |   ..  ||..   .  ... . .. .|.   . . | .. |||  ||| |||
aqGPldntladfWrmiweyncstivllt......kdkcsqywplkivik.eerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvp

EPPQSLVRFVRAFRDVIG--TDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLA
. |  |.|.|.  | .     . ..|.|||||||||.|..|.|| .|. ... . ||.. .|  .|..|  .||   ||  |.  || 
dypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1307-1403 1.6e-12 41.4 In-house 3-95 (95) alignment 
Range on Protein: 1307-1403
Range on HMM: 3-95/95.0
RPVHVKDFSEHYRIMSADSDFRFSEEFEELKHVGrDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDddgSDYINANYMPGHNSPREFIVTQG
.|.||  |  |   | ..||  | .||  .       . .     .| ||||| ||.||| .|  |    |   |||||| .. |.     .| .||
kpihvsvfhshvlemhsnsdqefdnefksismts.gapytvgsseanipknrflnifpydatrvvlttkrd...sdyinacfvdgyarkncyiaaqg
0043336 (Phosphotyrosine protein) phosphatases II 1308-1582 1.1e-91 302.4 In-house 1-274 (278) alignment 
Range on Protein: 1308-1582
Range on HMM: 1-274/278.0
PVHVKDFSEHYRIMSADSDFRFSEEFEELKHVGRdQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHS
|..|||. .... . ...  ....||||| ..     .|.|.||.|..|||...|||||||| ||.... | .||||||.|..|.| ||.||.|||||..
pisvkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe

TREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPvdRVAMFYGDIKVQLIIDTHYHDWSISEFMVS--RNCESRIMRHFHFTTWPDFGVPEPPQSLVR
| | ||||.|| ... |||||...|.||.||.||||  .  . |||..| |.  .|..|. .  . |.  .. |||. .|.|.. |||.||||....|..
tvedFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllld

FVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLL
|..|.|... ..  |..|||||||||.||||||...|....|   ||.. .|  .|. |  .|||..||. ....||
flkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1308-1586 1.5e-91 301.5 In-house 3-280 (288) alignment 
Range on Protein: 1308-1586
Range on HMM: 3-280/288.0
PVHVKDFsEHYRIMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHS
|.|...  ..  ..||..   ||||.. |  ...... . ..|. | .|||. ||||||. | ||. ... .|.|||||.|. |... ...| ||||| .
pihispv.akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPlad

TREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMVSRNCESRIMRHFHFTTWPDFGVPEPPQSLVRFV
| ..||.. .| ..  |||||   |.|..||..||| .     ||...|.|. . . .|.   .... .. . . . ......||| ||||  . |. ..
tvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllell

RAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLE
|        |. ||||||||||||.||||||| ........||.|..|.|  .||.| ..|||..||. |...|| . |
rqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslie
subfamily_Ptp69D_pd Subfamily Ptp69D 1308-1585 1.3e-77 255.9 In-house 3-286 (307) alignment 
Range on Protein: 1308-1585
Range on HMM: 3-286/307.0
PVHVKDFSEHYRIMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHS
.....| .| ..    |.|| . .|.|.|..   |. .....   |  |||. .| ..|. | ||...  .. ||||||... |..  ..||. |.|. .
aiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPvea

TREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDrVAMFYGDIKVQLIIDTHYHDWSISEFMVSRNC-------ESRIMRHFHFTTWPDFGVPEPP
| ..|||| .| ..  ||||.   || |.||..|||..   . |||| |.|.   . .|. | |. ||..        .|| .  .|.|.|.|. ||| .
tigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPeva

QSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVL
..|.....  |..  ..  ||.|||||||||||.|.||| .||.... | |||| .|  .|..| ..||  .||| ... ||   
rgllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldys
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1308-1587 4.6e-74 244.3 In-house 3-285 (305) alignment 
Range on Protein: 1308-1587
Range on HMM: 3-285/305.0
PVHVKDFSEHYRIMSADSDFRFSEEFEELKHVgrDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHS
.. ..|.... . ....||  . .....| .   ....   .   |. |||...| ..|..|..|.. ...| ||||||.|. |...  ..||.||||..
iialddlaayikearvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkn

TREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVA-MFYGDIKVQLIIDTHYHDWSISEFMVSR---NCESRIMRHFHFTTWPDFGVPEPPQSL
| ..|||. .|   . |||||.  | |..|| ||||      . .|...|.|   ... |. . .. .|    . ||| . ....|.||| |||. . ||
tvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsl

VRFVRAFRDVIGTDMR-PIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLEG
.....  .     |   |..|||||||||.|.|||.|  |....| . ||.|... ..|..|. |||| .||| .|. |   .. 
lslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitc
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1309-1590 5.8e-96 316.3 In-house 2-285 (318) alignment 
Range on Protein: 1309-1590
Range on HMM: 2-285/318.0
VHVKDFSEHYRIMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHST
..|.|. .| | . .. .  .|||.|.|... .  .   .. |.|. |||..|||.|||.| |||..... |||||||||..|... ...| .|.||  |
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

REEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPvDRVAMFYGDIKVQLIIDTHYHDWSISEFMVSRN--CESRIMRHFHFTTWPDFGVPEPPQSLVRF
 |.|||| || ||. |||||.. |.|..|...||| .. .. ||...|.|  .... |. . || |.|.   |||..| .|.|.||| |||| . ||. .
ieDfWrmvWeqnsavivmltqeeergkakvhryWP.skgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldl

VRAFRDVI-GTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLEGKEH
||  . .   ....||.||||||||| |.|||.| .|..|..   ||.|..|  .|..|  |||||.||. |.. ||  |.  . 
vrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdt
subfamily_PTPRG_pd Subfamily PTPRG 1309-1600 2e-87 288.7 In-house 1-301 (563) alignment 
Range on Protein: 1309-1600
Range on HMM: 1-301/563.0
VHVKDFSEHYRIMSADSDFRFSEEFE--ELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGS-DYINANYMPGHNSPREFIVTQGPL
|.||.|..|   . ||.| .||||||  . ... .|  ..... |.|. ||| .||..||.|| ||.|. . ... |||||||. |..  ..||.|||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

HSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVaMFYGDIKVQLIIDTHYHDWSISEFMVSR-------NC-ESRIMRHFHFTTWPDFGVP
..| . |||| || |.  |||.|   |.||.|||.||| | . . || ..|.||   .    .. ....         .| . . .|..|.|.||| |||
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdes.etygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvP

EPPQSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLEGKEHLLADSlE
| .   . ||.       ... ||.|||||||||.||.|.|| .|. |.. . |..||..  .| .| |.|||| ||. .|. || .. .||  | .. .
ehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellae.q

LHA
...
vee
subfamily_PTPRK_pd Subfamily PTPRK 1309-1588 4.3e-77 254.0 In-house 4-281 (314) alignment 
Range on Protein: 1309-1588
Range on HMM: 4-281/314.0
VHVKDFSEHYRIMSADSDFRFSEEFEELKHvGrdqaCSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHST
..|.|  ..  .. .   . | ||.| |   |       |.   || |||...||.||.|| .|...|.|  ||||||... ... |..||||||||..|
irvadllqsiallkraegygfkeeyeslfe.g....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqet

REEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAmfYGDIKVQLIIDTHYHDWSISEFMVSR----NCESRIMRHFHFTTWPDFGVPEPPQSLV
 ..|||. .. |. .|||||   |.|| || .||| |     ||||||.|.  .   .  .  | |..      | |..|.|.|..|||..||   ..|.
vkdfWrlvydencasivmltelvevgrvkClkyWPedtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgll

RFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLA-VLEGK
..||        .  .|.|||||| ||.|||||.| .|. |.. . ||.| .| ..|...| ||.||.||. |.. .|  .| |.
klvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcge
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1309-1586 2e-65 215.6 In-house 2-284 (290) alignment 
Range on Protein: 1309-1586
Range on HMM: 2-284/290.0
VHVKDFSEHYRIMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDD-D-GSDYINANYMPGHNSPREFIVTQGPLH
. |..|.|.     |  . .| ..|. |.   ....   .. . |...|||.||..||  |  |.|. .. |   .|||| |. |..  ...|.||||..
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

STREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMfYGDIKVQLIIDTHYHDWSISEFMVSRNCE---SRIMRHFHFTTWPDFG-VPEPPQS
.|  .||.. |. .. .|||||   |.|..|| ||||   ... || ....|. ......  . .. |  . .   .... ....|.|.. | |..|  .
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqti

LVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLE
|. . .  .    .  ..|.||||..||||..|.|..  ... ..   .|.| ..  .|  .  .|||.|||  |.| .|  |.
llvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1310-1587 1.4e-61 203.0 In-house 3-280 (287) alignment 
Range on Protein: 1310-1587
Range on HMM: 3-280/287.0
HVKDFSEHYRIMSADSDFRFSEEFEELKHVGRDQACSFANL-PCNRPKNRFTNILPYDHSRFKLQpvddDDGSDYINANYMPGHNSPREFIVTQGPLHST
 |. |.|  .   | ..  |.. |  |..|....     |. . |..|||.|.||..|  |  |.    .   ||||| .. |... ..||....|. .|
pvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfnt

REEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVaMFYGDIKVQLIIDTHYHDWSISEFMVSRNC---ESRIMRHFHFTTWPDFG-VPEPPQSLV
  .||.. .. |  |||||..  |. .|.| |||| ..  . .|. ...|. ....... . .. | ..    . . .. ...|.|.. | |.||  .|.
arnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtill

RFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLEG
 . . ..        .|.||||..||||..|.| .  ... ..   .|.| ..  .|  .  .||| .||  | . .|. |. 
vieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleylds
0040438 (Phosphotyrosine protein) phosphatases II 1311-1585 2.7e-95 314.6 In-house 2-276 (317) alignment 
Range on Protein: 1311-1585
Range on HMM: 2-276/317.0
VKDFSEHYRIMSADSDFRFSEEFEELKHVGRDqACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTRE
|.|. ...  . . .  ...||||.| ..  |  .|.|.||.|..|||...|||||||| ||.|.. | .||||||.|..|.| .|.||.||||| .| |
vldlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntve

EFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVdRVAMFYGDIKVQLIIDTHYHDWSISEFMVS--RNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVR
 ||||.|| ... |||||...|.|||||.||||  .  . |||..|.|.  ...... . ...|.  .. |||...|||.|.|||.|||. |..|..|..
dFwrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfle

AFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVL
| |...  .  |..|||||||||.|||||....|....|   ||.. .|  .|. |  .|||..||. ....||  |
avrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1311-1596 7.8e-61 201.0 In-house 7-300 (325) alignment 
Range on Protein: 1311-1596
Range on HMM: 7-300/325.0
VKDFSEHYRIMSADSDFRFSEEFEELKHVGrDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTRE
| .. ||     |. .  |. ||. |  ..  .|   | .| |. |||| |....|.||  |.  .||  ||||||.|.  .     |. .| || .| .
vvnlvehvekkkaqdqdgfahefgllpsdd.giakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatin

EFWRMC--WEsnsRAIVMLTRCFEKGREKCDQYWPVD-RVAMFYGDIKVQLIIDTHYHDWSISEFMVSR--NCESRIMRHFHFTTWPDFGVPEPPQSLVR
..||.   |.    ..|...  ...| ..| .||| .   .  .| ..|.|.   .. |.    . | .  . |.| .. |.. .|.|.||.. | .|. 
dlWrlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlis

F---VRAFRDVIGT---DMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVL-EGKEHLLADSL
.   | |  . . .      ||.|||||||||.|.||.|  .|... .   ||||| |  .||.|  ||.|  ||. |...|  ..  |.  .   |.
ilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssf
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1311-1609 5.1e-55 181.7 In-house 4-304 (439) alignment 
Range on Protein: 1311-1609
Range on HMM: 4-304/439.0
VKDFSEHYRIMSADSDFRFSEEFEELKHVGRDQACS--FANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHST
 ..| ||   .  . .  |.|.||... .  | ||   .|    ...|||. .. ..||.|  || .     | ||||||. |.  .. .| |||| . |
rdefqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkket

REEFWRMCWESNSRAIVMLTRCFEKGRekcdqYWPVDRvAMFYGDIKVQLIIDTHYHDWSISEFMVSRN----CESRIMRHFHFTTWPDFGVPEPPQSLV
 ..|||. .| ..  |||||  .|  .     ||| |   ..|||| |.   .    .. |  | |  .       | . .||...|||  ||     ..
tddfwrlviekktvtivmltnlvesyk.....ywpsda.evcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvl

RFVRAFRDVIG-TDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVL-EGKEHLLADSLELHAND
 |.||        .. |..|||||||||.|| ||||  |....  . ||| |||  .||.|  |||.  ||| |....|  .  |.  .. | .. . | 
dflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkkefna

GYEVTKI
|.    |
gfstrdi
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1314-1586 3.2e-80 264.6 In-house 14-291 (298) alignment 
Range on Protein: 1314-1586
Range on HMM: 14-291/298.0
FSEHYRIMSADSDFRFSEEFEELKHVGR---DQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTRE
...   .. . .  ....||..|..|     ..  . |. | |. |||...|...|.||  |. .|.|. |||||| .. ...    ||.||.||..| |
lqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetve

EFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPvDRVAMFYGDIKVQLIIDTHYHDWSISEFMVSRNC--ESRIMRHFHFTTWPDFGVPEPPQSLVRFVR
.|||| .| .. .|||||   |... |. .||| |. .  ||.|.|.|  . .. |  . ...||..   ..| .|..|||.||| ||||  .|.. ..|
dFWrmvteedigtiVmltnleeldktkyhkywP.degketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllr

AFRDvIGTDMR--PIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLE
  |    ..    |.||.|||||||||||||.| .|....|.  ||.| .| ..||.|. .||||.||| |..  | .|.
kvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1317-1586 1.1e-81 269.0 In-house 5-277 (281) alignment 
Range on Protein: 1317-1586
Range on HMM: 5-277/281.0
HYRIMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMC
| . .|....  | ||.|.|...|.|.. . .. . |. |||..||  ||..| |..| ...  .||||||..|| ....|.|.||||. .. ..||.| 
hlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmv

WESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMV-SRNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIG
|| . .||||.||  |.|. || .||| |. .. |||..|. .  .. . .   .|..  ...|.| ......|.||| |||. .. |. | .. . .  
weqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlklte

TDM-RPIIVHCSAGVGRSGTFIALDRILQHIH-KSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLE
..   |...||||||||.||.|||||...... .   .|.  .|  .|||| .||||  ||  ... .| .|.
kktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
0036941 (Phosphotyrosine protein) phosphatases II 1319-1588 2.5e-92 304.6 In-house 5-280 (297) alignment 
Range on Protein: 1319-1588
Range on HMM: 5-280/297.0
RIMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLqpvdDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWE
.......  ....||||| ..  .  .| |.||.|..|||...||||||.| ||    ||.|||||||.|..|.. .|.||.|||||..| |.||||.||
llekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvwe

SNSRAIVMLTRCFEKGREKCDQYWPVD-RVAMFYGDIKVQLIIDTH--YHDWSISEFMVSR--NCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDV
 |.. |||||...|.|||||.|||| . .  . |||..|.|.  ..  . |. . .. |.   | |||...|||.|.|||.|||| |.||..|....|.|
qnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkv

IGT--DMRPIIVHCSAGVGRSGTFIALDRILQHIH---KSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLEGK
.    .  |..|||||||||||||||.| .|| ..   |   |||. .|  .|. | ..|||..||. ....||  |  |
lkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk
0047943 (Phosphotyrosine protein) phosphatases II 1319-1583 6.5e-91 299.8 In-house 4-270 (273) alignment 
Range on Protein: 1319-1583
Range on HMM: 4-270/273.0
RIMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLqpvdDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWE
.......  .. ||||.|. .  .  .|.|.||.|. |||...|||||||| ||    .|.|||||||.|..|.|..|.||.||||| .| |.||||.||
llekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvwe

SNSRAIVMLTRCFEKGREKCDQYWPVDRV--AMFYGDIKVQLIIDTHYHDWSISEFMVSR--NCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVI
 |.| |||||...|.|||||.|||| .     . ||...| |.  ....|. . ......  . |||...|||.|.|||.|||. ..||..|... |...
qnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkal

GT--DMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLA
 .  .  |..|||||||||.||||||| .|....|   ||.. .|  .|. |  ||||..||. ....|| 
ealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
0045098 (Phosphotyrosine protein) phosphatases II 1323-1586 4.6e-80 264.2 In-house 3-273 (278) alignment 
Range on Protein: 1323-1586
Range on HMM: 3-273/278.0
ADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKlqpvddddgsDYINANYMPGHnsPREFIVTQGPLHSTREEFWRMCWESNSR
|... ... |||.| . |  . ...|....|..|||...|||||||| |          |||||.|..|.  |..||.||||| || . ||||.|| ...
alasldlllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgit

AIVMLTRCFEKGREKCDQYWPvDRVAMFYGDIKVQLIIDTHYHDWSISEFMVS------RNCESRIMRHFHFTTWPDFGVPEPP--QSLVRFVRAFRDVI
.|||||...|.|||||.|||| ..  . |||..| |.  ....|. .  ..|        ..||| ..|.|...|||.|||. |  .|. ....  |...
vivmltelvelgrekcaqywp.eggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefireal

GT-------------DMRPIIVHCSAGVGRSGTFIALDRILQHIhkSDYVDIFGIVFAMRKERVF-MVQTEQQYVCIHQCLLAVLE
 .             .  |..|||||||||.||..|.. .|...   . ||.. .|  .|. | . .||...||. ....|| .|.
kllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1323-1586 4.5e-46 151.9 In-house 14-294 (301) alignment 
Range on Protein: 1323-1586
Range on HMM: 14-294/301.0
ADSdfrFSEEFEELKHvGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDD--DDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESN
...   |.|...|||. |.|. |.      |.. ||| || .||. |. |.|  .      .||||.|. | .. ..||..|||...|  .|||. |.  
snk...feeqykelke.gedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqek

SRAIVMLTRCFEKGREKCDQYWPVDRV-AMFYGDIKVQLIIDTHYHDWSISE-----------------FMVSRNCESRIMRHFHFTTWPDFGV-PEPPQ
  .|||.|   |. ..|| ||||  .     .| ..|.|. .. | |. | .                 | |... .|. .  .. | ||. || .||  
pvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprt

SLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLE
 |             .  |..||||..|.|||......  |        ||.|... |.|. .  .|.| .||. |.. .   |.
vLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1324-1589 1.2e-61 203.4 In-house 24-288 (297) alignment 
Range on Protein: 1324-1589
Range on HMM: 24-288/297.0
DSDFrFSEEFEELKHVgRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSprEFIVTQGPLHSTREEFWRMCWESNSRA
..|. |||||  | .    |.   |.   | .|.|..|||||| || ||. |.||  |||.|| ...| .   ..| || | ..| ..||.| .. .  .
htdv.fseeflclpea.niqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvst

IVMLTRCfEKGREKCDQYWPVDRVAMfYGDIKVQLIIDTHYHDWSISEFMVSRNC--ESRIMRHFHFTTWPDFGVPE--PPQSLVRFVRAFRDVIGTDMR
||||.   ... .|| .||. . |.  .||. |.|   .. .  .  |. |...     |... ..|. |||  |..    .||. ..   |.. ..   
ivmlndd.nerdkkcaryWsdkgvtt.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnae

-PIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLEGKE
 |..|||.||||| | ....| .. .... . |||||.|  .|.||...|||..||  ... .| .|  ..
gPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsed
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1324-1583 1.1e-40 134.4 In-house 3-257 (267) alignment 
Range on Protein: 1324-1583
Range on HMM: 3-257/267.0
DSDFRFSEEFEELKHVGRDQAC-SFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDdgsdYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSR
|..  . .|||..|..  ...  |      |. .||. . ||||..|  |.  ...    |||| |. |..  . |||||.||. |  .|. .  . .  
deeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvp

AIVMLTRCFEkgrEKCDQYWPVD-RVAMFYGDIKVQLIIDTHYHDWSISEFMVSRNCES-RIMRHFHFTTWpDFGVPEPPQSLVRFVRAFRDVIGTDMRP
 ||.||. |.   ..  ..||     |  | |. |.  ..    |. |  . .  . || . .  ...  | .  . . |     |    .. .    ||
vivlltkvft...dnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkw.nintnnkpylkplfgilaknqlengnrP

IIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLA
..|.||.||||||||. .|  |. . . . .|||  .  .|. |. .|.| ..|. ||. |  
lvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_PTPN6_pd Subfamily PTPN6 1327-1589 1.8e-73 242.2 In-house 26-301 (306) alignment 
Range on Protein: 1327-1589
Range on HMM: 26-301/306.0
FRFSEEFEELKHVGRDQACS--FANLPCNRPKNRFTNILPYDHSRFKLQpVDDDDGSDYINANYMP--GHNSPREFIVTQGPLHSTREEFWRMCWESNSR
  |.||||||..    .  |   .. | |. |||. ||||.||.| .|.  ..  |||||||||.    ..| ...| ||| |..| ..|||| |. |||
agfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensr

AIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMVS---RNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIG----
 |||.|.  |.|.||| .|||       ||.|.|. . ... .|. . |..||   .. |.| ....||..||| |||. |. .. |..  .        
vivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeelee

TDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDY---VDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLEGKE
....||.||||||.|| |||| .| .|. |.|. .   .||  .|  .|. |  .|||||||  ... . . .| |.
aeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk
subfamily_PTPN1_pd Subfamily PTPN1 1327-1595 6.5e-70 230.1 In-house 6-278 (290) alignment 
Range on Protein: 1327-1595
Range on HMM: 6-278/290.0
FRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDddgsDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVM
 ...| ......  .|  .. |.|| ||..||. .. |||||| ||.  |     |||||. .  ..  |..|.||||| .| . ||.| || .|.|.||
rlykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvm

LTRCFEKGREKCDQYWPVDRV--AMFYG--DIKVQLIIDTHYHDWSISEFMVSR--NCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRD--VIGTDM
| .. ||.. || |||| .    .. .    .||.||   ... . .. . .      |.| . |||.|||||||||| |.....|.   |.  .. .|.
lnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdv

RPIIVHCSAGVGRSGTFIALDRILQHIHKSDY---VDIFGIVFAMRKERVFMVQTEQQyvcIHQCLLAVLEGKEHLLADS
 | ..|||||.||||||. .| .| .|.|.|    |||   . ..|| |. ..|| .|   ..   ||.|||   .  ||
GpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadq...lrfsylaileGakvikgds
subfamily_PTPN12_pd Subfamily PTPN12 1328-1586 8.2e-76 249.6 In-house 9-278 (290) alignment 
Range on Protein: 1328-1586
Range on HMM: 9-278/290.0
RFSEEFEELKHVGR----DQ--ACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNS
.|..||..||.. .    ..    . .. . |. |||. .|||||.|| .|.  ....||||||||.. | ... |.| .||||  | ..|||| || | 
efakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknv

RAIVMLTRCFEKGREKCDQYWPVD-RVAMFYGDIKVQLIIDTHYH-DWSISEFMVSRNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMR
. .||. | .| |. ||..|||     .. .|...|.|. . . . |. |  . | .. |||... ||.| ||| |||. ..||.......|..  ..  
eivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqeseda

PIIVHCSAGVGRSGTFIALDRILQHIHKSD---YVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLE
|..||||||||| || ||.| . . ...      .|.| .|  .||.|. .|||..||. ...... ...
PlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1328-1591 2e-68 225.5 In-house 20-283 (315) alignment 
Range on Protein: 1328-1591
Range on HMM: 20-283/315.0
RFSEEFEELKHVGRDQACSfANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVML
 ||||| .|      .  . |  . | .|||. ||||.|..| ||. .||.  |||||| |... .. . .| .||||... ..|||| ....  .|||.
lfseefhdlpdPdiyrqrv.aretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmv

TRCFEKGREKCDQYWPV-DRVAMFYGDIKVQLIIDTHYHDWSISEFmVSRNC-ESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPIIVHC
|   |  . || ||||  .  .. .| |||.|.      |  . .. | |.  ||| .  |.|| ||| ||..   ||...... .   |..  ...|||
tkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhc

SAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLEGKEHL
||||||.| .|..| ....|.... ||.| .|  .|..|...||||..|  |.. .|  |  .. |
saGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1328-1586 1e-53 177.2 In-house 21-237 (392) alignment 
Range on Protein: 1328-1586
Range on HMM: 21-237/392.0
RFSEEFEELKHVGRDQAcSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVML
 |.||| .|      .  . |. . | .|||. |||||| .| ||. .||   |||.|| |.|. .. . .| .|||  .. ..|||| .. |  .|.|.
lffeefhdlpgpdiypq.tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamv

TRCFEKGrekcdqywpvdrvamfygdikvqliidthyhdwsisefmvsRNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPIIVHCSA
|.  |                                           .  . | .  |||| ||| .||.   ||..|..  .   |   .|.|.||||
tklkegd.........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsa

GVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLE
||||.|  |..| .. | .|.  ||.| .|  .|..| .||||..||  |. ..|  | 
gvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledll
subfamily_PTPRN_pd Subfamily PTPRN 1328-1581 1.2e-48 160.4 In-house 30-288 (297) alignment 
Range on Protein: 1328-1581
Range on HMM: 30-288/297.0
RFSEEFEELKHVGRDQAC-SFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNsPRE--FIVTQGPLHSTREEFWRMCWESNSRAI
|...|.| |..   .... . |. . |  ||| ...||||||| ||.   ... ||||||  .  |. ||.  .| ||||| ||  .||.| ||. .  |
rlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhd.prapayiatqgplastvadfwqmvweqGvvvi

VMLTRCFEKGREKCDQYWPvDRVAMFYGDIKVQLIIDTH-YHDWSISEFMVS--RNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPI
|.|||  |.| ..|..||| |  .  |.  .|.|. .    .|. .  | .   .. |.| .  ||| .||. |||  ..||. | |           ||
vnltrleeegvkqckrywp.deGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpi

IVHCSAGVGRSGTFIALDRILQHIHKS-DYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCL
.||||.|.||.|..|..| .|... |    .||   .  .| .|  .|.|..|.  . ...
vvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav
0046845 (Phosphotyrosine protein) phosphatases II 1329-1586 5.2e-94 310.0 In-house 2-275 (284) alignment 
Range on Protein: 1329-1586
Range on HMM: 2-275/284.0
FSEEFEELKHVGRDQ--ACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDD-DGSDYINANYMPGH-----NSPREFIVTQGPLHSTREEFWRMCWESN
. |||||| ..  ..   .|.|.||.|. |||...|||||||| ||...|.| ..||||||.|..|.     .....||.||||| .| |.||||.|| |
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

SRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMVSR---NCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIG--
.| |||||...|.|||||.|||| .   . |||..| |.  ....|. . ......   . |||...|||.|.|||.|||. |..|..|.|. |...   
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

TDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSD---YVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLE
 .  ||.|||||||||.||||||| .|....| .    ||....|  .|. | .||||..||. ....||  | 
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk
DSPc_SM00195 1329-1585 7.6e-88 289.6 In-house 2-262 (263) alignment 
Range on Protein: 1329-1585
Range on HMM: 2-262/263.0
FSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLT
..||||.|.    .. .. |. . |. |||..|||||||.| ||.. ....|||||||||. |.|.....|.||||| || |.||||.|| ... |||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

RCFEKGREKCDQYWPVD-RVAMFYGDIKVQLIIDTHYH-DWSISEFMVSRNC--ESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPIIVH
...|.|.||||.||| .    . .|.|.|.|.  ...  .. . .. .. .   |.| ........||| |||. ..|.....||..    |   ||.||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVL
|||||||.|||...| ||..... . |||| || ..||.|  ||||..||  |....|...
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1329-1585 7.6e-88 289.6 In-house 2-262 (263) alignment 
Range on Protein: 1329-1585
Range on HMM: 2-262/263.0
FSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLT
..||||.|.    .. .. |. . |. |||..|||||||.| ||.. ....|||||||||. |.|.....|.||||| || |.||||.|| ... |||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

RCFEKGREKCDQYWPVD-RVAMFYGDIKVQLIIDTHYH-DWSISEFMVSRNC--ESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPIIVH
...|.|.||||.||| .    . .|.|.|.|.  ...  .. . .. .. .   |.| ........||| |||. ..|.....||..    |   ||.||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVL
|||||||.|||...| ||..... . |||| || ..||.|  ||||..||  |....|...
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1329-1589 1.4e-67 222.9 In-house 20-280 (515) alignment 
Range on Protein: 1329-1589
Range on HMM: 20-280/515.0
FSEEFEELKHVGRdQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLT
||||| .|         . |.   | .|||. |||||| .| ||. ..|.  |||.|| |.|. .. . .| .|||.... ..|||. .. |  .|.|.|
fseefhdlpgpni.ypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvt

RCFEKGREKCDQYWPV-DRVAMFYGDIKVQLIIDTHYHDWSISEFMVSRNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPIIVHCSA
.  |  . || .|||     .. .| |||.|.      .  . .. | .. .|| .  |||| ||| |||.  .||...... .   |    |.|.||||
klkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsa

GVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLEGKE
|||| | .|..| .. |..... ||.| .|  .|..|...|||..||  |.. .|  |  ..
GvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrn
subfamily_PTPN23_pd Subfamily PTPN23 1329-1590 2.8e-58 192.0 In-house 17-282 (288) alignment 
Range on Protein: 1329-1590
Range on HMM: 17-282/288.0
FSEEFEEL----KHVGRDQACSFANlpCNRPKNRFTNILPYDHSRFKLQpvddDDGSDYINANYMPGHN--SPrEFIVTQGPLHSTREEFWRMCWESNSR
. ..|.||    ..  |..... |.  ..  |||...||||||.| ||.    .   ||||| .. .    .| .||.||.||.||  .||.| .|  |.
ldkkfkeleqkqdkearkrsiaiak..lyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcP.dfiatqaPlqstlnDFWlmvyeqkss

AIVMLTRCFEKGREKCDQYWPVDR-VAMFYGDIKVQLIIDTHYHDWSISEFMVSRNC--ESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRD----VIG
 ||||.   |.|..|.|.||| |.  .. .||..| |   .. . ..  .. .. .   . . ..| ..|.||..|||. |..|..|. . ..    |  
viVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqr

TDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDY-VDIFGIVFAMRKERVFMVQTEQQYvciHQCLLAVLEGKEH
    |..|||||||||.|.|  .  ... ..| .  .||  .|  .|..| ||||...|.   .... ||||  ..
ksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeql...kfsyeavleaarr
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1329-1583 6.8e-48 157.7 In-house 13-267 (281) alignment 
Range on Protein: 1329-1583
Range on HMM: 13-267/281.0
FSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQP-VDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVML
| .|| .|      . |.  | | |  |||..||   | || .|.  . . . .||| |||.      | .|.|||| . || .|||| |. |. |||||
fkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivml

TRCFEKGREKCDQYWPVDR-VAMFYGDIKVQLIIDTHYHDWSISEFMVSRNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRdvigTDMRPIIVHCS
 .  |  |||| .|.| .  ... .  . |.    |  .    . . .| . |.|.. |. .  |||. |||  . ... .|  |    .   | ..|||
cqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkir....arstppvihcs

AGVGRSGTFIALDRILQHIHKS-DYVDIFGIVFAMRK-ERVFMVQTEQQYVCIHQCLLA
||||||||..|..  || ||      ||  ||  .|   |   ||| |||. | . || 
agvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1329-1392 3e-08 27.6 In-house 15-77 (244) alignment 
Range on Protein: 1329-1392
Range on HMM: 15-77/244.0
FSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPvDDDDGSDYINANYMPGH
  |||  |    |.   . | | .|  |||. ||||.|..|  |      .|||||||||. | 
akeefvglsdhtreflqtnavlsanatknryinilpfdetrvilss.skkegsdyinanyiqgs
subfamily_PTPN9_pd Subfamily PTPN9 1330-1583 1.7e-75 248.9 In-house 19-288 (297) alignment 
Range on Protein: 1330-1583
Range on HMM: 19-288/297.0
SEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTR
|.|..|...         ..|..|  |||.|..| ||..| .|. ||.|. |||||||.. |.. .. || |||||. | ..|||| ||.. . ||| ||
skeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttr

CFEKGREKCDQYWP-VDRVAMFYGDIKVQLIIDTHYHDWSISEFMVS--RNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTD---------
. |.|| || ||||  .  .. .||..|. . . ...|. .. . ..  .. ||| . || |..|||.|||.  .||. .... |.  ..          
vvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewk

----MRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLA
      ||.||||||.||.||||.||  |..... . ||..  |  .|. | |..||..||.  ....| 
ghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_PTPN13_pd Subfamily PTPN13 1330-1586 3.3e-66 218.4 In-house 14-270 (273) alignment 
Range on Protein: 1330-1586
Range on HMM: 14-270/273.0
SEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQpvddDDGSdYINANYM--PGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVML
.|||.||...   . |. ..   |. |||. |.||||..| ||.    |.|. ||||...  |  .   |.|..||||  | ..||.| || ... |.|.
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklg....degg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv

TRCFEKGREKCDQYWPVD--RVAMFYGDIKVQLIIDTHYHDWSISEFMVSR--NCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDvIGTDMRPIIV
|   |||. ||..|||.   .  . .. ..|.|.  ............|.     ||| . |..|..||| |||  ...|..||.  |  . ||  ||.|
tlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrr.lqtdagPivv

HCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLE
|||||.|||||.|..| .|. |..   .|.  ||  .|. |  .|||..||. ... .| ||.
hcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_PTPN14_pd Subfamily PTPN14 1330-1585 1.4e-52 173.6 In-house 26-296 (300) alignment 
Range on Protein: 1330-1585
Range on HMM: 26-296/300.0
SEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDdGSDYINANYMPG--HNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVML
  |.|....   |  .| |.|| | .|||| ..|||...| .|.|  ..  ..||||  .      . |..||.||||. | ..||.| ||.. . ||||
fteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivml

TRCFEKGREKCDQYWPVD---RVAMFYGDIKVQLIIDTHYHDWSISEFMVSR--NCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIG--TDMR-
|.  |.|.||. .|.| .   .  . .|  ||.    .. .    . . .      | | . |. .| ||| |||| ... . ... .. |    .... 
teeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseve

------PIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVL
      |..|||||||||.|  |  | ... ... . .||  ..  .|. | ..|||  ||  ... |.  |
skeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1330-1581 7.6e-51 167.6 In-house 13-273 (287) alignment 
Range on Protein: 1330-1581
Range on HMM: 13-273/287.0
SEEFEELKHVGRDQACSF--ANLPCNRPKNRFTNILPYDHSRFKLQpVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVML
 .|.. ||.  .  .  |  |.   .  |||....||.|..|  |   . . |||||||||.....   .||..|||. .|  .|||. .| .| .....
dkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitm

TRCFEKGREKCDQYWPVDRVAMFYGDIKVQLI-IDTHYHDWSISEFMVSR--NCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVI-----GTDMR
||  |..| || .|||  .| |  |   | |.  |    ....  . .      |.|... ... .||| ...    .|.|||   .. |     .... 
treveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevG

PIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCL
|..||...|.||||...|.  ...   .   ||.  .|  .|. |  .||.  |.  . . |
PlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyeal
subfamily_ptpA1_pd Subfamily ptpA1 1330-1538 2.8e-40 133.3 In-house 24-249 (418) alignment 
Range on Protein: 1330-1538
Range on HMM: 24-249/418.0
SEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHnSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTR
 |||  |.        |  .   |  |||.||||| .|.| .|. ..| .|||||||||. |   |..||.|||||  |  .|||| ||   | ||||.|
keefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivmlsr

CFEKGREKCDQYWPVDR----VAM------FYGDIKVQLI--IDTHYHDWSISEFMVSRNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAF----RDV
  |. | |||.||| .     ...       .|   |.|.  |.   ..    .  .. . |.| . ....  |||. .|.  | . .....      ..
esencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqi

IGTDMR--PIIVHCSAGVGRSGTFIAL
| .  |  ||||||||||||.||| . 
ipssdrnvpiivhcsagvgrtgtfcta
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1331-1584 2.3e-44 146.6 In-house 20-276 (307) alignment 
Range on Protein: 1331-1584
Range on HMM: 20-276/307.0
EEFEELKHVGRDqACSFANLPCNRPKNRFTNILPYDHSRFKLQpvDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRC
.||..| .   . . .   . .|  |||....   |..|  ..   |   |||| |||.     |. ||..||||..|. .|| |. . .  ...|| ..
defrvlakktpe.gvtveafsantdknryqdvkcqdkgrivvk..fdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckv

FEKGREKCDQYWPVDRV-AMFYGDIKVQLII-----DTHYHD---WSISEFMVSRNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRdvigTDMRPI
 | .. ||.||||...   . .|.    . .     ..   |     .... |    .|| ..|. .. ||| |||.   . . .. | |     |  |.
ielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr....ydtnpv

IVHCSAGVGRSGTFIALDRILQHI-HKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAV
.|||||||||||| .|.  . . .    .  |.  .|  .|..| . .||| ||. .|. ||  
vvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
subfamily_CG42327_pd Subfamily CG42327 1331-1507 7.7e-31 101.9 In-house 6-187 (319) alignment 
Range on Protein: 1331-1507
Range on HMM: 6-187/319.0
EEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHN-SPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTR
. .||.... .  | . .  .  ..|.|. |..|  ..|  || . ||| . |..|.|. |.. .|  .| .| .| ..  .|||. || .|| || || 
dvaeefrdlPqliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltd

CFEKGREKCDQYWPVDRV---AMFYGDIKVQLIIDTHYHDWSISEFMVSR--NCESRIMRHFHFtTWPDFGVPEPPQSLVRFV
 .|.| ..| .|.|          ||||.| |      . . || ... |  . ||| . |. .  |.. .||  ...|.  .
lselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliaml
subfamily_PTPN3_pd Subfamily PTPN3 1332-1586 9.8e-68 223.1 In-house 20-276 (280) alignment 
Range on Protein: 1332-1586
Range on HMM: 20-276/280.0
EFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQpvddDDGSDYINANYM----PGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVML
.||.|    .. |.| |..| | .|||. .|||||. | ||.    .  .|||||||.    |...    .|.|||||..| ..||.| || .|. ||||
qfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivml

TRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMVSRNC--ESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPIIVHC
|   |.|| || ||||     . ||...|..  . . . . . |......   |.| . .. .. ||| |||. ......||.  |..  .. .|..|||
ttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhC

SAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLE
|||.||.| .|.|.  |. | ... | .  ||  ||  |  .|||..||  . ...|.| |
saGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvye
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1332-1582 3.1e-54 178.8 In-house 11-263 (283) alignment 
Range on Protein: 1332-1582
Range on HMM: 11-263/283.0
EFEELKHVG-RDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDddgsDYINANYMP---GHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVML
 .| ||...  |. .  |    |..|||. .|.|.|  | .|..       ||||| ..|    ..  ...|..|.||. |. .||.| .. .  |||||
frevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivml

TRCFEKGREKCDQYWPvDRVAMFYGDIKVQLIIDTHYHDWSISEFMVSRN---CESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPIIVH
|.  |  |.|| ||||  | .. ||.  | |  .|  . ..| |...  |    .. .. |. .  | ..|   .  |||.| .           ||.||
tklqedlrikCsqyWP.krGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvh

CSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLL
||.|.||...|||.   ....  .  ||.| .|  ||..|. .||| .||  .|.  |
CstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvl
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1340-1583 4.3e-70 231.4 In-house 11-253 (284) alignment 
Range on Protein: 1340-1583
Range on HMM: 11-253/284.0
GRDQ-ACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTrcfekgREKC
| .    .||||. |. |||...||..|... ||....  ..|||||| .. |. ..  .| |||||  | ..|||| ||.|. .||.||      ..||
gvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkc

DQYWPVDRVAMfYGDIKVQLIIDTHYHDWSISEFMVSR---NCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIG--TDMRPIIVHCSAGVGRSG
 |||| . |   ..  ||..   .  ... . .. .|.   . . | .| |||  ||| |||. |  |.|.|.  | .     . ..|.|||||||||.|
sqywplkivik.eerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtg

TFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLA
..|.|| .|. ... . ||.. .|  .|..|  .||   ||  |.  || 
vyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1341-1507 5.4e-35 115.7 In-house 21-190 (297) alignment 
Range on Protein: 1341-1507
Range on HMM: 21-190/297.0
RDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDddDGSDYINANYM--PGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKC
| .. | |. .    |||...|| .| .| ||. |    ..|||||.|.  |  ...  .|..||||..| ..||.. .| . |.|||...  | ||.||
rgesfssakrnsslrknryrdilatddtrvkllrvi..terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkc

DQYWP-VDRVAMFYGDIKVQLIIDT--HYHDWSISEFMVSRNCESRIMRHFHFTTWPDFGVPEPPQSLVRFV
  ||| |.   .  ||. |. . .|  ...   ..|. .    ||| .||  | .||| |||   . |||| 
apywpsvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfq
subfamily_CG7180_pd Subfamily CG7180 1342-1582 9.3e-55 180.3 In-house 31-287 (296) alignment 
Range on Protein: 1342-1582
Range on HMM: 31-287/296.0
DQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGReKCDQY
   |  .    || |||  ...|||. |  |. .| .. |||||| |. ..  ..|.|||..| ..| .||||. .. .. |.|.||. |.  . .. .|
igdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsy

WPVDRvAMFYGDIKVQLIIDTHYHDWSISEFMVSRN------------CESRIMRHFHFTTWPD-FGVPEPPQSLVRFVRAFRDVIGT-----DMRPIIV
|| .     ||.| |...   .| .  | .| . ..             | ||...|..|.|.    ||   ..|. ..|  | ...      .  |..|
wpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvv

HCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLL
..| |..||| ..|.|  |. ..| . ||.|. |  .|..|  .|.. ..|  | . ||
vssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvll
0049772 (Phosphotyrosine protein) phosphatases II 1342-1587 8.8e-45 149.1 In-house 35-282 (314) alignment 
Range on Protein: 1342-1587
Range on HMM: 35-282/314.0
DQACSFANLPCNRPKNRFTNILPYDhSRFKLqPVDDDDGSDYINANYMPGHnspREFIVTQGPLHSTREEF----------WRMC--WESNSRAIVM---
.. . .|.|..|| |||...|||.| .| .| |  . .|||||||.|. |.   . ||.|||||  | . |          |||   .. |.| |||   
eltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrd

------------------LTRCFEKGrekcdQYWPVDRVAMFYgdikvqliidthyhdwsiSEFMVSRNCESRIMRHFHFtTWPDFGVPePPQSLVRFVR
                  |... ..|      .... .....                   .|      .| ........  .||...| ... . .|..
evladelsrLdaAlgKtpllildgng.....neptaadlellk..................eelydpelferlgikylri.pvpDgsap.lledfdefle

AFRDVigTDMRPIIVHCSAGVGRSGTFIALDRILQHIHksdyVDIFGIVFAMRKERV-----FMVQTEQQYVCIHQCLLAVLEG
.....   . .|..|||.||.||.|||.... .. . .    |..  ..  .|. |       .... .||. |...||  |. 
fieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealleylkf
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1342-1590 1.2e-33 111.1 In-house 41-295 (310) alignment 
Range on Protein: 1342-1590
Range on HMM: 41-295/310.0
DQACSFANLPCNRPKNRFTNILPYDHSRFKLQpVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQY
|.. ..     .  |||.....  | || ||. .|     ||| |||.        ||..||||  |  .|||| ..  . .|..| .  |.|| ||  |
dssltyeaykkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgy

WPVDRVAMFYGDIKVQLIIDThYHDWSISEFMVS------------RNCESRIMRHFHFTTWPDFGVPEPPQSLVRfvraFRDVIGTDMRPIIVHCSAGV
||   |.  || |.|  . ..  ... | .. |.             | .   .   ..  ||| |||.     |      | .      | .||||||.
wpslgvtetygcirvtnlses.seefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp....qrllaqvrhgpcvvhcsagk

GRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLEGKEH
.| .. .||.  ...... ..||.  ..  ..|.|.  .||| ||. |..  ..   |...
drlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifargete
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1343-1600 1.7e-67 222.6 In-house 39-294 (315) alignment 
Range on Protein: 1343-1600
Range on HMM: 39-294/315.0
QACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYW
.    |.   |. |||. ||..||.|| .|  .. |..|||.|||...|.| .| .| .|||. .. ..|||. .| .   |||||   |. ..|...||
hpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekyw

PVDrvAMFYGDIKVQLIIDTHYHDWSISEFMVSRNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRIL
| .   . || | | .. . .. ....  . |  . . | .  .|.|.||| |||.   .|. ..|  .    ... .|.|||||||||.||||.|| .|
pdk..kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavl

QHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLEGKEHLLADSLELHA
....  . .|.. ..  .|. |. |||. .||  |.. ||  .   .  .|. | |. 
dqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqr
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1344-1585 6.3e-28 92.5 In-house 26-270 (285) alignment 
Range on Protein: 1344-1585
Range on HMM: 26-270/285.0
ACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDdddgSDYINANY--MPGHNSpREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQY
 |...   .|   ||....   . .|  |.  |     ||| |..  |||..    .| |||||  |  .||.| .. .   ..||   || | |||  |
nctytayeanpdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdq.styittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcaly

WPVDR--VAMF------YGDIKVQLIIDTHYHDWSISEFMvSRNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIgTDMRPIIVHCSAGVGRSG
.|     |  |        . | . |  | .   .. .     . |   | | .   |||   ||  . .. . .  . |     .|| |||||||||. 
ypeklgevvkfgkyeitlteckeeaiagtilnaltvinte.dasseplymnhvqvpwwpdqlapedarpmielykwvkkvn.pkekpicvhcsagvgrta

TFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVL
||. .|    .| .   .... ||  ||  |.  ||.  |.. ..  |.  .
tfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1344-1502 5.1e-13 42.3 In-house 18-160 (169) alignment 
Range on Protein: 1344-1502
Range on HMM: 18-160/169.0
ACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINAnympghnsprefivtqgplhstreefwRMCWESNSRAIVMLTRCFEKGR---EKCD-
   .|.| ||  ||| .  |   | | ||| | .| |||||||                           || ||.|.  ||.|  . .|     || | 
nnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddknnfwpekedy

QYWPVDRVAMFYGDIKVQL----IIDTHYHDWSISEFMVSRNCESRIM---RHFHFTTWPDFGVPEPPQS
|  |   .  .| |            |.  .  .   ||  . .. .    . .|..|||. |||. |  
qlhpavilgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqspvh
0040439 (Phosphotyrosine protein) phosphatases II 1345-1583 3.5e-81 267.7 In-house 3-244 (249) alignment 
Range on Protein: 1345-1583
Range on HMM: 3-244/249.0
CSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPV
.|.|.||.|..|||...||||||||.||.....  .||||||.|..| ...|.||.|||||..| | ||||.|| ....|||||...|.|||||.|||| 
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

dRVAMFYGDIKVQLIIDTHYHDWSISEFMVS--RNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGT--DMRPIIVHCSAGVGRSGTFIALDR
 .  . |||..|.|.  ....|. . .....   . |||  .|...| |||.|||. ...|..|..| |... .  .  |..|||||||||.|||||.. 
.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

ILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLA
.|....|   ||.. .|  .|. |  .||...||. ....|| 
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
0042113 (Phosphotyrosine protein) phosphatases II 1345-1584 9.5e-80 262.8 In-house 1-242 (245) alignment 
Range on Protein: 1345-1584
Range on HMM: 1-242/245.0
CSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPV
.|.|.||.|..|||...||||||.|.||.|.. | .||||||.|..|.. .. ||.|||||..| | ||||.|| ....|||||...|.||.||.|||| 
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

dRVAMFYGDIKVQLIIDTHYHDWSISEFMVS--RNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIG-TDMRPIIVHCSAGVGRSGTFIALDRI
 .  . |||..|.|.  .|. |. . ...|.  .. |||  .|.|.. |||.|||. ...|..|... |...  ..  |..|||||||||.|||||....
.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylm

LQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAV
|....|   |... .|  .|. |  .|||..||. ....||  
leqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
0037934 (Phosphotyrosine protein) phosphatases II 1345-1582 1e-73 243.2 In-house 2-239 (243) alignment 
Range on Protein: 1345-1582
Range on HMM: 2-239/243.0
CSFANLPCNRPKNRFTNILPYDHSRFKLqpvdddDGSDYINANYMPGHnsPReFIVTQGPLHSTREE----FWRMCWESNSRAIVMLTRCFEKGREKCDQ
.|.|.||.|..|||...|||||||| ||      .||||||||....   || .|.||||| .| |.    ||||.|| ....|||||...|.|||||.|
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPvDRVamFYGDIKVQLIIDTHYHDWSISEFMVSR---NCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGT--------DMRPIIVHCSAGV
||| . |   |||..|.|.  .|..|. . ......   . ..|  .|.|.. |||.|||. |..|..|... |..|          . .|..|||||||
ywp.gev..tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGv

GRSGTFIALDRILQHIhksDyVDIFGIVFAMRKERVF-MVQTEQQYVCIHQCLL
||.||.||.. .|...   . ||.. .|  .|. | . .|||..||. ....||
gRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeall
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1345-1502 7.5e-13 41.6 In-house 18-159 (169) alignment 
Range on Protein: 1345-1502
Range on HMM: 18-159/169.0
CSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINAnympghnsprefivtqgplhstreefwRMCWESNSRAIVMLTRCFEKGR---EKCD-Q
  .|.| ||  ||| .  |   | | ||| | .| |||||||                           || ||.|.  ||.|  . .|     || | |
nfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddknnfwpekedyq

YWPVDRVAMFYGDIK---VQLII-DTHYHDWSISEFMVSRNCESRIMR---HFHFTTWPDFGVPEPPQS
  |   .  .| |      . .  .|   .  .   .|  . .. . .    .|..|||. |||. |  
lhpavilGewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspvh
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1347-1586 4e-43 142.5 In-house 40-272 (288) alignment 
Range on Protein: 1347-1586
Range on HMM: 40-272/288.0
FANLPCnrpKNRFTNILPYDHSRFKLQpvddDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVD-
| . |.   ..|..|.   | .| ||.    ||   ||.|| .. .. .| .| .| ||..| ||.|.|  ||. . ||||..  |||.|| ..|.|.  
fianpt...rdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPskl

----RVAMFYGDIKVQLiiDTHYHDWSISEFMVSRNCESRI-MRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVigtdMRPIIVHCSAGVGRSGTFIALDR
    |.  .  ..|..   .   .  ..| . .|.. | .. ... |.  |.| ||||  .| .|..  ....     .||.||.||||||.||.|    
Gekarigrlctvvkkkr..adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlksl....qkPivvhssaGvGrtgtlilili

ILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLE
.|. .  .|.. |  ..  .|.||   .|||.||. .|.|.|  | 
aleslrlddflgirsllaklreerfkaiqtemqylyvhrcvleell
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1348-1587 3.3e-77 254.1 In-house 4-244 (250) alignment 
Range on Protein: 1348-1587
Range on HMM: 4-244/250.0
ANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREkCDQYWPVDRv
|. | |. |||...|...|.||  |.... |. |||||| .. |..  . ||.|||||..| |.|||| .| .| .|||||   |.... . |||||.. 
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek.

AMFYGDIKVQLIIDTHYHDWSISEFMVSRNCES--RIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGT-DMRPIIVHCSAGVGRSGTFIALDRILQH
|  |||..|.|  . .. |. . ....|.. ..  ||.|..||..||| ||||  .. . ...  .      . .|.||.|||||||||.|||.| .|..
aekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavler

IHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLEG
..|.  ||.| .. ..||.|. .|....||| ... .|  |. 
lkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1349-1583 1.4e-64 212.9 In-house 24-266 (274) alignment 
Range on Protein: 1349-1583
Range on HMM: 24-266/274.0
NLPCNRPKNRFTNILPYDHSRFKLQPVD-DDDGSDYINANYMPGHNS-PREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDR
... .  |||...||| ..||  |.. . .|. |.||||||. | .   . .. ||||| .| ..|||| .. ... |||||.  |. ..|| .|.| ..
dvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdae

V---AMFYGDIKVQLIIDTHYHDWSISEFMVSRNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIG---TDMRPIIVHCSAGVGRSGTFIALDR
    .  |||....    .. .|.|. .....   ..| . |. .| |||  .|. ...|...|.  ..      . . |..||||||.|| | ||| . 
dyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisi

ILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLA
 .......  ||...||  .| .|  ||||..||  ||. |  
avrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1351-1425 9.3e-08 26.0 In-house 35-114 (347) alignment 
Range on Protein: 1351-1425
Range on HMM: 35-114/347.0
PCNRPKNRFTNILPYDHSRFKLQPVD-----DDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIV
  .  |||  .    | .|  | | .      ||   |||| ..   |. .|.|.|| || .|  .||.|    .   .|
ekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvv
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1352-1583 2.6e-65 215.1 In-house 19-262 (270) alignment 
Range on Protein: 1352-1583
Range on HMM: 19-262/270.0
CNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPG-HNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVD---RV
 ..  ||...|||  ..| .|.....|. . ||||||..| .......| ..||| .| ..|||| ||....||||.|   ||||.||..||| .   .|
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekv

AMFYGDIKVQLIIDTHYHDWSISEFMVSRNCESRIMRHFHFTTWPDFGVPEPPQ------SLVRFVRAFRDVIGTDM--RPIIVHCSAGVGRSGTFIALD
.. .|.|||  . ... . . . .  . .. |.| . ||...|||| |||. ..      .|.. .|| | .        |..|||||||||.||.||||
kledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialD

RILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLA
 ... ....  ||.  |. ..||.|. .||. .||  ... .. 
iavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1352-1584 9e-56 183.7 In-house 6-236 (239) alignment 
Range on Protein: 1352-1584
Range on HMM: 6-236/239.0
CNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGH-NSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPvDRvAMF
 |. |||..||. |||||  |. . .|  ||||||.|.  .  ||. .| ||| .  .  .|||| |.     |||||   |  ..|| |||| |  .  
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.ds.tsk

YGDIKVQLIIDTHYHDWSISEFMVSR--NCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKS
| ...| |     . |. |  |..|.  . | | . ..||| ||| |||.   ... . |          || ..||||||||.|.|. .| .|.. .| 
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

DYVDIFGIVFAMRKERVFMVQTEQQYVCIHqclLAV
  ||||  | |.|..| .|||| .||| ||   |||
ktvdifnyvkairedrphmvqtseqyvfih...lav
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1352-1582 1.2e-55 183.3 In-house 7-238 (239) alignment 
Range on Protein: 1352-1582
Range on HMM: 7-238/239.0
CNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGH-NSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPvDRvAMF
 |. |||..||. |||||  |. . .|  ||||||.|.  .  ||. .| ||| .  .  .|||| |.     |||||   |  ..|| |||| |  .  
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.ds.tsk

YGDIKVQLIIDTHYHDWSISEFMVSR--NCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKS
| ...| |     . |. |  |..|.  . | | . ..||| ||| |||.   ... . |          || ..||||||||.|.|. .| .|.. .| 
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

DYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLL
  ||||  | |.|..| .|||| .||| || ..|
ktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1352-1585 2.8e-37 123.0 In-house 54-289 (305) alignment 
Range on Protein: 1352-1585
Range on HMM: 54-289/305.0
CNRPKNRFTNILPYDHSRFKLqpvDDDDGSDYINANYMPGHNSP-REFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRV--A
 .  |||....   |.|  ||   |.   |||| |||.     | . ||..||||  | .||| |  . .   |||| .  | |. || ||||. .    
iaitknryqdvpcqdqsavkl...dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekl

MFYGDIKVQLIIDTHYHD----WSISEFMVSRNCES-RIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRdviGTdMRPIIVHCSAGVGRSGTFIALDRILQ
 . . | |. .  ..  .      |. . .. . .    .||...| ||| |||    . . .. | |   |.   ||.||||||.||.|| .|.. ||.
elksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair...gs.kvpivvhcsagigrtgtivaieyile

HIHKSDYV-DIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVL
.| .   .  .  .| |.| .| | .|.. ||. ||. .|  .
kiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1352-1584 1.9e-18 60.9 In-house 50-284 (302) alignment 
Range on Protein: 1352-1584
Range on HMM: 50-284/302.0
CNRPKNRFTNILPYDHSRFKLQPVDDddgsDYINANYMPGHNSPREFIVTQGPLHSTR---EEFWRMCWESNSRAIVMLTRCFEKGReKCDQYWP-----
 |  ||. ...  .|. . ||.   |    .|.||  .   .  |. |..| |  ..    |||||| .. .   .|.| .  |  .   ....|     
knlkknqsedvpildsnlvkleaepd....syvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgd

-VDRVAMFYGDIKVQLIIDTHyHDWSIsEFMVSRNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAF-RDVIGTDMRpIIVHCSAGVGRSGTFIALDRI
 ..  .||    ||.   ... . ..| | .     .| ..   ..| |..  ||.   .|.. .       | .| . ...    |.|| |.|..|   
ykeygkmfvNnrkVekaeeek.tryvi.EvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikaden.tvivSknGaGRagafltlava

LQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAV
.....|.. . |  || ..|..|  .|.. .||| .. .||  
veklqkgkepnikeivksiRsqRpravdslkQyvslyiallly
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1352-1581 1.6e-15 51.6 In-house 46-275 (303) alignment 
Range on Protein: 1352-1581
Range on HMM: 46-275/303.0
CNRPKNRFTNILPYDHSRFKLQpvdDddgSDYINANYMPgHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFY
 |  ||||....  |||. ||    |   | || |.|.   .| .  |.|| ||  |  .||.|  | . . ...|    |  .   |  .| ..  . .
knmdknrfvdvicldhskvkls...d...ssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

GD--IKVQLIIDTH-YHDWSISEFMVSRNCESRIMRHFHFTTWPDFGVPEP-PQSLVRFVRAFRDVIG--TDMRPIIVHCSAGVGRSGTFIALDRILQHI
 .  |.|  .      . |..    ||      ..   |. .||   .|      .|. .   . |.   .| .| .    .|.||.|||  ..     .
eersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlsl

HKS-DYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCL
|.    .|.   .  .|. |.  ||   |.  ..  |
hseqasldlvkclenvrngrlhavqnlsqfsvvytll
Y_phosphatase Protein-tyrosine phosphatase 1353-1582 8.1e-81 266.2 Pfam-A 1-234 (235) alignment 
Range on Protein: 1353-1582
Range on HMM: 1-234/235.0
NRPKNRFTNILPYDHSRFKLqpVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWP-VDRVAMFY
|. |||...|||||..| ||   .... ||||||||. |......||.||||| || |.||||.|. ....|||||.. |||||||.||||  ..  . |
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GDIKVQLI--IDTHYHDWSISEFMVSRNCES---RIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIH
|||||.|   . .. ... .... .. ..|.   |.....|.|.||| |||| |.||....|...    ..  |..|||||||||.|||.||| .|....
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

KSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLL
. . ||.. ||  .||.|  |||...||. .....|
aeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 1353-1582 8.1e-81 266.2 In-house 1-234 (235) alignment 
Range on Protein: 1353-1582
Range on HMM: 1-234/235.0
NRPKNRFTNILPYDHSRFKLqpVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWP-VDRVAMFY
|. |||...|||||..| ||   .... ||||||||. |......||.||||| || |.||||.|. ....|||||.. |||||||.||||  ..  . |
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GDIKVQLI--IDTHYHDWSISEFMVSRNCES---RIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIH
|||||.|   . .. ... .... .. ..|.   |.....|.|.||| |||| |.||....|...    ..  |..|||||||||.|||.||| .|....
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

KSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLL
. . ||.. ||  .||.|  |||...||. .....|
aeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1353-1582 2.6e-56 185.5 In-house 3-236 (237) alignment 
Range on Protein: 1353-1582
Range on HMM: 3-236/237.0
NRPKNRFTNILPYDHSRFKLQPVDDDdgSDYINANYMPGHN-SPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFY
|. |||. ||  |||||  |.    .  ||||||.|. | . .|...| .|||| |. ..||.| |. .   |||||   |. ..|| .|||       |
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GDIKVQLIIDTHYHDWSISEFMVSRNC---ESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIG--TDMRPIIVHCSAGVGRSGTFIALDRILQHIH
| . | |  . .. |...  ...|..    | |..  ..||.||| |||.   .|.|| .   .     ..  | |.||||||||.| |. .| .|.. .
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

KSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLL
.   |||.  |... ..| ...||..||| ||| .|
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
0041856 (Phosphotyrosine protein) phosphatases II 1353-1588 2.2e-49 162.9 In-house 1-174 (182) alignment 
Range on Protein: 1353-1588
Range on HMM: 1-174/182.0
NRPKNRFTNILPYDHSRfklqpvddddGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTrcfekgrekCDQYWPvdrvamfyg
|..|||...||||||||          ..||||||.. |   ...||.||||| || ..|.|| .| . ..||.||         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

dikvqliidthyhdwsisefmvsrNCESRIMRHFHFTTWPDFGVPEpPQSLVRFVRAFRDvigtDMRPIIVHCSAGVGRSGTFIALDRILQHihksdYVD
                        . . |   ..... |||.|||. ...|..|... ..    . .|..|||||||||.||..|.. ....      |.
........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvs

IFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLEGK
.. .|  .|. |  ||.|..||. ....|| .|..|
leeavklvrsrRpgmvitpnqyfflqlallellllk
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1353-1592 5.3e-37 122.2 In-house 48-294 (305) alignment 
Range on Protein: 1353-1592
Range on HMM: 48-294/305.0
NRPKNRFTNILPYDHSRFKLQPVDdddGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMF-Y
.. |||. ..   |. | ||..       .|| |||.     |. || || ||. |  .|| ||.. .  || ||    ||| .|| .|.. .   .. .
eagknrykdvgcldnnrvklegpw...pheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlef

--GDIKVQLIIDT----HYHDW---SI--SEFMVS-RNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGtdmrPIIVHCSAGVGRSGTFIALD
  .. |... ...    ....     .  .....    ...| . |.|.  ||| |||   .... ..   |   |    ||.||||||.||.|. . |.
eekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpskg....pivvhcsagigrtgsvvmle

RILQHIHKSDYVDI-FGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLEGKEHLL
 ||. .   . ..    |.  .|..|   .||..||. .|| .|  .. |. | 
yildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkklld
subfamily_egg_pd Subfamily egg 1353-1583 7.7e-25 82.2 In-house 40-268 (307) alignment 
Range on Protein: 1353-1583
Range on HMM: 40-268/307.0
NRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKgrEKCDQYWPV---DRVAM
|. | |   .   | || ||.        |.| ||.. |.    |||..| ||  | ..|||| .. . . |||||   |   |.|. |||    | . .
nlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvt

FYGDIKVQLIIDTHYHD--WSISEF-MVSRNCESRIMRHFHFtTWPDFGVPEPPqslVRFVRAFRDVigtdMRPIIVHCSAGVGRSGTFIALDRILQHIH
  | .... .   .  |  . .... .|  . | | . |.    .   .    |   .| .|  |..     .|..|..  || ...|..|..  | .. 
vpGslrienlkvdskadplfrvtklklvGgddeerflehwqg.dvnnssdvysp...lrvlrklrnl....skpvvvqdilGvskaatlvaieiallsll

KSDY--VDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLA
.       .   |  .|..| . |..  .|. ... .| 
rGpitkslvlravvflrlrrrlsvesvllylfvyrlvlf
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1353-1438 1.1e-07 25.7 In-house 34-118 (332) alignment 
Range on Protein: 1353-1438
Range on HMM: 34-118/332.0
NRPKNRFTNILPYDHSRFKLQPVDDDDgsDYINANYMPGHNSPREFIVTQGPLHSTR-EEFWRMCWESNSRAIVMLTRCFEKGREKC
|   ||   .  .|||| .| | |  |  |. ||... |..    .|..| |.       ||||  | .   |...    || . |.
nmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1354-1589 3.3e-30 99.9 In-house 44-280 (312) alignment 
Range on Protein: 1354-1589
Range on HMM: 44-280/312.0
RPKNRFTNILPYDHSRFKLQpvddDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPvDRVA-----
.  ||. ||  .|  || |      |   || ||..     |  |..|||||..|   ||...    | .|..|.   | | ||| .|   | |.     
kdlnrypniqcwdrgrftla....gdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyis.divgfvdle

--MFYGDIKVQLIIDTHYHDW---SISEFMVSRNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRdvigTDMRPIIVHCSAGVGRSGTFIALDRI--
    | .   .. |  . .|     .   .|    .   . |. ...||| |.|.  ..  |.. | .     | .|.| ||||||||.||.. .. .  
dhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavk....kdkkpviahcsagvgrtgtlaliesmia

-LQHIHKSDYVDIFgivFAMRKERVFMVQTEQQYVCIHQCLLAVLEGKE
 |.|  | .  |.|     .||.|   |..  |||   .|.| .|  | 
alrhprkqnvkdsf...vllrkdrarsvrvfpqyvyalrcvleflyskg
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1355-1583 1.1e-44 147.2 In-house 58-281 (290) alignment 
Range on Protein: 1355-1583
Range on HMM: 58-281/290.0
PKNRFTNILPYDHSRFKLQpvDDDDGsDYINANYMPGHNSPreFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVD-RVAMFYGD
 |||. ..   | .|  |.  |  || ||. |||. | ...  ||.|||.|..|  ..|||  . .  |||||   .|.|. ||.||.|     .. .|.
kknrykdvvcndktrvilk..dGydG.dyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGe

IKVQLIIDTHYHDWSISEFMVSR---NCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGtdmrPIIVHCSAGVGRSGTFIALDRILQHIHKSDY
| |    ...  .  |   .  |   .  . ...|..  .|||  |.    .|.| .|. | . |    |..||||||.||.|||.|..  || . .   
itvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkasG....pvvvhcsaGiGrtGtfvaievglqilldGke

VDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLA
.|. ..| |.|. |.  || . ||. . . || 
ldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1356-1446 4.2e-24 79.9 In-house 50-154 (350) alignment 
Range on Protein: 1356-1446
Range on HMM: 50-154/350.0
KNRFTNILPYDHSRFKLQ----PVD----DDDGSDYINANYMPGH------NSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQY
|||..|||||.||| ||.    . |       ..|||||||.         |.   .| ||.|| || ..|.... . . . |..||  .| ..|||..|
knrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrY

WPVDR
|.   
Wqegs
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1356-1443 8.4e-14 45.6 In-house 51-154 (349) alignment 
Range on Protein: 1356-1443
Range on HMM: 51-154/349.0
KNRFTNILPYDHSRFKLQPVD-----------DDD---GSDYINANYM--PGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCD
|||. .||||.||| ||.              . |     |||||||.  .  .  . .| || || || ..|...    . . .. |.  .|.. ||||
knrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcd

QYWP
.|| 
iywq
subfamily_eak_pd Subfamily eak 1357-1512 8.4e-15 49.0 In-house 56-209 (332) alignment 
Range on Protein: 1357-1512
Range on HMM: 56-209/332.0
NrFTNILPYDHSRFKLQPVDDDdGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDR-VAMFYGDIK
|   .|.|||.   .| .   .    ||||  .   .  |..|.|  . ..    ||.|  | .| |||.|    |.. || |.|.| .    . .| ..
n.vvkivpydrylvrltssqln.rlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGild

VQLIIDTHYHDWSISEFMVSRNCESRIMRHFHFTTWPDFGVPEPpQSLVRFVRAFRD
|.     .        ...|.  |.  . |...  | .. .|   . .. . .. ..
verkefvkrniletrllelskGnethrvlhykvfGwtettlpky.edflalrkvmke
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1363-1495 1.8e-08 28.7 In-house 3-125 (130) alignment 
Range on Protein: 1363-1495
Range on HMM: 3-125/130.0
LPYDHSRFKlqpvddddGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCfekgrEKCDQYWPVDRVAM-FYGDIKVQLIID
|... || .        | .||||...   .  .|.. || ||  |  .||.|  |     .|.|        |. |.|||       .  || | |   
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsv.....eeedeywpdsePlewyeediivtltdr

THYHDWSISEFMVSRNCES--RIMRHFHFTTWPDFG
  ..    |.. ....     . .  |. . ||  |
defknikasnleiesdlneshqaltmfqisnwpsdg
0044763 (Phosphotyrosine protein) phosphatases II 1364-1582 4.1e-34 113.1 In-house 1-168 (178) alignment 
Range on Protein: 1364-1582
Range on HMM: 1-168/178.0
PYDHSRFKLQPVDDDDGSDYINANYMPGHnspreFIVTQGPLhstrEEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVamfygdikvqliidth
|.|..|..|... .  .||||||... ..     ..... |     ...... .| . ..||.||  .| |..|||.||| .                  
pldrtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag................

yhdwsisefmvsrncesrimRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHihksdYVDIFGIVFAMRKE
                     ..... .||.|||. .. . .||.. .... .. .|..||||||||||||..|.. ....      .... ..  .|. 
....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrer

RVfMVQTEQQYVCIHQCLL
|  .|... |.  .... |
Rp.ivpnpgqlrqLyefel
0046846 (Phosphotyrosine protein) phosphatases II 1373-1585 3.5e-43 142.7 In-house 4-173 (176) alignment 
Range on Protein: 1373-1585
Range on HMM: 4-173/176.0
QPVDDDDGSDYINANYMPGHnsprEFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVdrvA---MFygdikvqliidthyhdwsi
..  .| ..||||||.. |.     .|.|||||..| ..|..| .| . .|.|.|| ..|.|| ||..|||.        .                   
rllgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe...leklgi...................

sefmvsrncesrimrHFHFTTWPDFGVPEPpQSLVRFVRAFRDVIGTDmRPIIVHCSAGVGRSGTFIALDrilqHIHKSDYVDIFGIVFAMRKERV-FMV
               ..... |||.|||.  . | ..... |...  . .|..||||||.||.||..|..     ....  .... ..  .|. |  ..|
...............qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgav

QTEQQYVCIHQCLLAVL
||..||  .....| .|
qtpeQyrflyefellll
0043147 (Phosphotyrosine protein) phosphatases II 1378-1579 1e-42 141.1 In-house 2-155 (172) alignment 
Range on Protein: 1378-1579
Range on HMM: 2-155/172.0
DDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCfekgrekcdqywpvdrvamfygdikvqliidthyhdwsisefMVSRN
|.|||||||.|....  |..||.||||| .| ..||||..| . ..||.||..                                          .. . 
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..........................................lydpe

CESRIMRHFHFTTWPDFGVPePPQSLVRFVRAFRD-VIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIhksdyvDIFGIVFAMRKERVFMVQTEQQYVC
...|   ..... |||.||| ... | .|..  .. ..  .  |..|||||||||.||..|.. .|...      ... .|  .|. |  .||...|| .
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylmllgl......sleeavalvrekRpgavqnpsqyrf

IHQ
...
lyy
0051429 (Phosphotyrosine protein) phosphatases II 1380-1587 6.9e-53 175.3 In-house 3-227 (272) alignment 
Range on Protein: 1380-1587
Range on HMM: 3-227/272.0
GSDYINANYMPGHNS---PREFIVTQGPLHSTREEFWRMcWESNSRAIVMLTRCFEKGREKCDQYWP-----------VDRVAMFYGDIKVQLIIDTHYH
 |.||||....| ..   |. .. ..|||. | ..|||. .| . ..||.|....|.||.|||.|||            .   ..||.. | |.  ....
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DWSISEFMVS---RNCESRIMRHFHFTTWPDFGVPEPPqsLVRFVRAFRDvigtdMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVD--------IF
|. . |....    . |.| ..|.|.| |||.|||. .  |........|      .|..||||||..|.||..||...|. ..... ||        ..
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

GIVFAMRKERVFMVQTEQQYVCIHQCLLAVLEG
..|  .|. |  .||||.||......||..|..
eaveelraqrpgavqteeqylflyeallellrs
0036282 (Phosphotyrosine protein) phosphatases II 1380-1579 1e-46 154.1 In-house 1-164 (174) alignment 
Range on Protein: 1380-1579
Range on HMM: 1-164/174.0
GSDYINANYMPGHNSPREFIVTQGPLHstreeFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVdrvamfygdikvqliidthyhdwsisefmvSRNCE
|||||||... ..  ....|..||||      ||.|..| .....|||....|.|..|| .|||                                |. .
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredl

SRIMRHFHFTTWPDFGVPEPPQsLVRFVRAFRDVIGT-DMRPIIVHCSAGVGRSGTFIALDRILQHIHkSDYVDIFGIVFAMRKERVFMVQTEQQYVCIH
.|   ..... |||.|||. .. | .||.. ....   . .|..|||||||||.||..|....|.... ...||.. .| ..|. |  ||||..||  ..
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly

Q
.
y
0051082 (Phosphotyrosine protein) phosphatases II 1381-1581 2.5e-34 113.4 In-house 3-149 (151) alignment 
Range on Protein: 1381-1581
Range on HMM: 3-149/151.0
SDYINANYMPGHnspreFIVTQGPlhstREEFWRMCWESNSRAIVMLTRCFEKGreKCDQYWPVDRvamfygdikvqliidthyhdwsisefmvsrnces
|||||..|. |.     .....||     ..|... .| . ..||.|.  .| |  .| .|.|                                     
sdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg..................................

RIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDvigTDMRPIIVHCSAGVGRSGTFIALDRILQHihksdyVDIFGIVFAMRKERVFMVQTEQQYVCIHQC
.  .|.... |||.|.|. ......|.....|   ..  |..||||||.||.||..||...|..      |... ..  .|. |  .||..||.......
ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfa

L
|
l
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1381-1574 1e-31 104.8 In-house 75-270 (301) alignment 
Range on Protein: 1381-1574
Range on HMM: 75-270/301.0
SDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMF---YGDIKV---QLIIDTHYHDWSISEFMV
   | ||..| .  |. ||.|||||..|.|.|| |.   .   ||||..  ||  |||..| ||.    .     .||.   .||.. . .  ..     
rvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtleveds

SRNCESRIMRHFHFTTWPDFGVPeppQSLVRFVrAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQY
... ..| . |. ...|.| |||   .| .     . ...    .||.||||||.||| .||. . . ....    ...   .  .|..|   |||..| 
tgkfatrtvthyqysewtdrgvP...kshaelf.dlmelvkksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsql
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1381-1581 6.5e-16 53.3 In-house 46-255 (290) alignment 
Range on Protein: 1381-1581
Range on HMM: 46-255/290.0
SDYINANYMPGHNSpREFIVTQGPLH-------STREEFWRMCWESNSRAIVMLTRCFEKGRE----KCDQYWPVDRV-AMFYGDIKVQLIIDTHYHDWS
.||| ||..   |   ..|.|| |..       || |.|| |  . ... .|||    || ..     | .| |      . .....|.     .  |  
ddyiHAnrvtcpng.lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddve

ISEFMVSRNCE-SRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRdvigTDMRPIIVHCSAGVGRSGTFIALDRILQHIH-KSDYVDIFGIVFAMRKERVF
. | .|  . |    . |  .  | .  |.| ...|.  ..  .    .   |.||||  |. || .. |..   | |  .|. | .  .. |.||.|  
tRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqral

MVQTEQQYVCIHQCL
........  .   .
aitsalelafvdagi
0049260 (Phosphotyrosine protein) phosphatases II 1388-1579 1.4e-38 127.3 In-house 1-144 (152) alignment 
Range on Protein: 1388-1579
Range on HMM: 1-144/152.0
YMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWpvdrvamfygdikvqliidthyhdwsisefmvsrncesrimrHFH
...|.. |.||| ||||.  | ..|||| .| . ..|||||...|.|..||.||.                                          ...
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qyl

FTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILqhihksDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQ
.. |||.|||. .| |  .... .  .  .  |..|||||||||.||..|.. .|        |... .|  .|. |  .|....|.  ...
hlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1392-1579 2.2e-21 71.0 In-house 1-198 (199) alignment 
Range on Protein: 1392-1579
Range on HMM: 1-198/199.0
HNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCfEKGRE-KCDQYWPVDRV-AMFYGDIKVQLIIDTHYHDWSISEFMVSRNC----ESRIMRH
|.. | .|.|| ||. |  .||.| ||. |  |||.    .| .|     |||.    .  || . |     |   |..|. .... |.     .| . |
hkgqrryiatqhplretmadfwqmvwetgsghivmvndd.qknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreish

FHFTTWPDFGVPEPpQSLVRFVRAFRDVIGT----DMRPIIVHCSAGVGRSGTFIALDRILQH--IHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQ
. ||.| .   |.    .| || | |.|          |.||||| | | .| |.|||  ..     |.  ||.| .   .|. |. .. . |.|  |.|
yqftswkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1396-1579 3.9e-21 70.1 In-house 4-197 (198) alignment 
Range on Protein: 1396-1579
Range on HMM: 4-197/198.0
REFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCfEKGRE-KCDQYWPVDRV-AMFYGDIKVQLIIDTHYHDWSISEFMVSRNC----ESRIMRHFHFT
| .|.|| ||. |  .||.| ||. |  |||.    .| .|     |||.    .  || . |     |   |..|. .... |.     .| . |. ||
rryiatqhplretladfwqmvwetgsghivmvndd.qknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

TWPDFGVPEPpQSLVRFVRAFRDVIGT----DMRPIIVHCSAGVGRSGTFIALDRILQH--IHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQ
.| .   |.    .| || | |.|          |.||||| | | .| |.|||  ..     |.  ||.| .   .|. |. .. . |.|  |.|
swkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1396-1456 6.3e-07 23.1 In-house 236-293 (440) alignment 
Range on Protein: 1396-1456
Range on HMM: 236-293/440.0
REFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKgreKCDQYWPVDRVAMFYGDIKV
  || || || ||  .|||.  . .  .|.|| .  .|    |  ||||.  .. .| . |
nafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftv
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1397-1495 7.2e-06 19.8 In-house 138-234 (244) alignment 
Range on Protein: 1397-1495
Range on HMM: 138-234/244.0
EFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCfekgrEKCDQYWPVDRVAMFY-GDIKVQLIIDTHYHDWSISEFMVSR--NCESRIMRHFHFTTWPD
|.|.|| ||  |  .||.|  |     .|.|        |. |.|||      .|  || | |     ...   |.. .    |   . .  |  . || 
eyiltqhpladtsmdfwkmmlerhvnvlvvlgsv.....eeedeywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwps

FG
 |
dg
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1402-1585 1.3e-17 58.2 In-house 97-288 (302) alignment 
Range on Protein: 1402-1585
Range on HMM: 97-288/302.0
QGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVD-RVAMFYGDIKVQLI-IDTHYHDW------SIS--EFMVSRNC--ESRIMRHFHFT
  | .||.| .| .  . |   .| |.   |.. .|| .|.  . .  . .|   |. . ..|. ...       .   |.  ..      . .  ..|.
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

TWPDFGVPEPPQSLVRFVRaFRDVIGtdmRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVL
.||| | |. ... .  .. | .      . ..|||||||||.||..|.   .|   | .  |.  ||  .|. |   ||.||| . .  |.   |
awpdhGapkeaytaldilk.fcesyk...knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkgl
subfamily_hpo-7_pd Subfamily hpo-7 1405-1547 8e-14 46.2 In-house 43-187 (263) alignment 
Range on Protein: 1405-1547
Range on HMM: 43-187/263.0
LHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVA-MFYGDIKVQLII---DTHYHDWSISEFMVSrNCESRIMRHFHFTTWPDFGVPEPP
|  | ..|...   ...  .|||.   |.|.|||..|.|...   . . ...|       |.  .   . . .     . . ..|. .. |..   || .
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlge.KkkthtvkhysykgWiekndpela

QSLVRFVRAFRDvigtdMRPIIVHCSAGVGRSGTFIALDRILQHI----HK
.. .. ... |.      ....||||.|.|||  |   . . |..    ..
reilnilkvarn.....skslvvhcstGiGrsaafsvaElvyqkmirsldt
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1408-1548 2.1e-15 51.5 In-house 40-182 (255) alignment 
Range on Protein: 1408-1548
Range on HMM: 40-182/255.0
TREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVA-MFYGDIKVQL---IIDTHYHDWSISEFMvSRNCESRIMRHFHFTTWPDFGVPEPPQSL
| ..|...   ...  .|||.   |.|.|||..|.|...   . . |..|     . |   .   |   . ..  . . ..|.... |..   || .. .
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstl.gekkkthtvkhysykGWieknaPelarei

VRFVRAFRDvigtdMRPIIVHCSAGVGRSGTFIALDRILQHI----HKS
   ... ||      ....||||.|.||| .|.  . . |..    ...
lnilkvvrd.....sksvvvhCstGiGrsaafvlaelvyqkmirsldtt
0048076 (Phosphotyrosine protein) phosphatases II 1462-1582 6.6e-24 79.6 In-house 36-140 (145) alignment 
Range on Protein: 1462-1582
Range on HMM: 36-140/145.0
ThyhdwsisefMVSRNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDmRPIIVHCSAGVGRSGTFIALDRILQhihksDYVDIFGIVFAMR
           .  .. ..|   ..... |||.|||. .. | .|... ....  . .|..|||||||||.||..|.. .|.       |... ..  .|
l..........tselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvr

KERVFMVQTEQQYVCIHQCLL
. | ..|....|.  .....|
sqrpgavpnpgqlrflyefel
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1477-1594 1.4e-22 74.7 In-house 85-204 (440) alignment 
Range on Protein: 1477-1594
Range on HMM: 85-204/440.0
NCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVI-GTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYV
  ||| ....|.  ||| |||.    ......   .    .   |..||||||.||.|  ||.| ||.. ..|| .||| .. .||..|  |||| .||.
giesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqya

CIHQCLLAVLE-GKEHLLAD
 .|...|  |  |   .| |
fvheavlegllcgdtliled
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1477-1583 2.8e-18 60.8 In-house 211-342 (350) alignment 
Range on Protein: 1477-1583
Range on HMM: 211-342/350.0
NCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGT----------DMRPIIVHCSAGVGRSGTFIALDRILQ----------HIHKSDYVD----
 ..  .. ....  |.| ..   |.|... .    |.| .             ||.||||||||| ||...|| .|.          . .|.|.      
asdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrD

-IFGIVFAMRKERVFMVQTEQQYVCIHQCLLA
 |. ||  .|| |. |||. .|.. |...|| 
lisiivnelrkqrismvqnldqfifiYeallf
0048179 (Phosphotyrosine protein) phosphatases II 1478-1579 1.4e-22 75.4 In-house 44-139 (144) alignment 
Range on Protein: 1478-1579
Range on HMM: 44-139/144.0
CESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDmRPIIVHCSAGVGRSGTFIALDRILqhihKSDyVDIFGIVFAMRKERVFMVQTEQQYVCI
.. |   ..... |||.|||. .. | .|........  . .|..|||||||||.||..|.....    | . .... ..  .|. | ..|....|.  .
fleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfL

HQ
..
le
PTPc_DSPc_SM00012 1483-1582 1.8e-34 113.5 In-house 2-104 (105) alignment 
Range on Protein: 1483-1582
Range on HMM: 2-104/105.0
MRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDM--RPIIVHCSAGVGRSGTFIALDRILQHIHKS-DYVDIFGIVFAMRKERVFMVQTEQQYVCIHQ
..|.|.|.|||.||||...|.....||....        |..|||||||||.|||.||| .||...|. . |||| || ..||.|  |||||.||. ...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

CLL
.||
all
0038934 (Phosphotyrosine protein) phosphatases II 1485-1538 7e-08 27.8 In-house 81-135 (194) alignment 
Range on Protein: 1485-1538
Range on HMM: 81-135/194.0
HFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTD-MRPIIVHCSAGVGRSGTFIAL
...   .||.|.. . . | ||...  ...  |    . ||| ||.||.||..| 
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa
subfamily_PTPDC1_pd Subfamily PTPDC1 1486-1581 1.4e-07 26.1 In-house 85-172 (182) alignment 
Range on Protein: 1486-1581
Range on HMM: 85-172/182.0
FHFTTWPDFGVPePPQSLVRFVRAFRDVIGTDmrPIIVHCSAGVGRSGTFIALDRILQHIHKSDyvdifGIVFAMRKERVFMVQTEQQYVCIHQCL
..  .|.|.||. . ....  |.    ..  .   . ||| || || |  ||   . ..  ...       .  .|..|   .|| .|  ....  
vynfgwkDygva.sleriLdivkvvafalqeg..kvavhChaGlGrtGvliacylvyakrltae.....kaiklvrskrpksiqtreqvelvkefa
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1487-1584 3.8e-11 36.9 In-house 224-343 (349) alignment 
Range on Protein: 1487-1584
Range on HMM: 224-343/349.0
HFTTWPDFGVPEPPQSLVRFVRAFRDVIGT----------DMRPIIVHCSAGVGRSGTFIALDRILQ-------HIHKSDYV-----DIFGIVFAMRKER
 .  |.| ..   |.|... .    |.| .          .. ...|||||| ||.|... || .|.       .  | ..       |. ||  .|| |
qvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqr

VFMVQTEQQYVCIHQCLLAV
. |||  .|.. |...||  
ismvqnlaqfiaiyealLky
PTEN_1 1490-1537 4.9e-08 28.0 In-house 101-149 (196) alignment 
Range on Protein: 1490-1537
Range on HMM: 101-149/196.0
TWPDFGVPePPQSLVRFVRAFRDVIGTDM--RPIIVHCSAGVGRSGTFIA
 ..|.|.| . ..| .... | . .  |   . ..||| ||.||||| .|
pieDhgap.slselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
subfamily_CG42327_pd Subfamily CG42327 1518-1581 7.9e-13 42.7 In-house 247-311 (319) alignment 
Range on Protein: 1518-1581
Range on HMM: 247-311/319.0
MRPIIVHCSAGVGRSGTFIALDRILQHIHKS-DYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCL
  |..|||| ||||.|. || |  .... .|   |||  .|. .|..|   |.| .||  |.. |
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1520-1584 5.9e-11 36.8 In-house 230-294 (297) alignment 
Range on Protein: 1520-1584
Range on HMM: 230-294/297.0
PIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAV
...|||||||||||  .  | ||. . |    |.  |.  .|..|  .||| .|.  ...  |. 
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkk
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1522-1585 2.8e-15 50.5 In-house 2-65 (69) alignment 
Range on Protein: 1522-1585
Range on HMM: 2-65/69.0
IVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVL
.||||.| ||.|||||.   .  |     ||||  |  ||| |  ||  |..|. ||  |   |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1522-1585 1.6e-14 48.0 In-house 1-64 (69) alignment 
Range on Protein: 1522-1585
Range on HMM: 1-64/69.0
IVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVL
.||||.| ||.|||||.   .  |     ||||  |  ||| |  ||  | .|. ||. |   |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal