Gene DUSP1 in Homo sapiens

Synonym: CL100, HVH1, MKP-1, MKP1, PTPN10, DUSP1

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP1
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP009_AA protein Get Run
HsapP009_AA_171-316 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Rhodanese Rhodanese-like domain 17-130 2.1e-14 46.0 Pfam-A 9-112 (113) alignment 
Range on Protein: 17-130
Range on HMM: 9-112/113.0
LgeRAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIvrrRAKGAMGLEHIVPNAELRGRLLAGAYHAVVLLDersaaLDGAKRDGTLALAAGALCREARAA
|  .. ...|||.||. ....||| |.|||.....   ......  .   ..   .     .  . ||. .       |... |. || . ....|.   
l..ekekvvllDvRspeeyakghIpgAvnvpldsl...yprrdlffkdklaeeleesgkkldkdktvvvyc.....rsgnrsggaaalllalilkelgyk

QVFFLKGGYEAFSA
.|..|.||.||..|
nvyvLdGGfeawka
subfamily_DSP1_pd Subfamily DSP1 156-315 2.5e-76 249.3 In-house 2-159 (163) alignment 
Range on Protein: 156-315
Range on HMM: 2-159/163.0
SAESGCSSCSTPLYDqggPVE-ILPFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRV
|...||......|||   ||| ||.||||||...||....|..|||||..|||....|.|| ...||....||..|||||..|.|.|.|||..|...|.|
srwlgcdldklklyd...PvekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkv

FVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAP
..|||||||||.|.||||||.|.||.|.|||.||||||||||||..|..|||..|...|. 
lihCqaGisRsstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkllle
PTEN_1 156-315 1.9e-40 133.8 In-house 28-194 (196) alignment 
Range on Protein: 156-315
Range on HMM: 28-194/196.0
SAESGCSSCSTPLYDqggpvEILPFLYLGSAYHASR-KDMLDALGITALINVSANCPN---------HFEGHYQYKSIPVEDNHKADISSWFNEAIDFID
.    .. .|.||..     || ..||.||. .... .|.|.. |||...|.|  ...         .|.....|...|.|| .. ..|..| .. .||.
riiamgkapsrpllq.....eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfie

SIK--NAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAP
...  . |. | |||.||..||.|.. ||||....   |||.|.|...|. ..|| ... .||..... || 
wllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaellae
0045098 (Phosphotyrosine protein) phosphatases II 160-313 4.5e-35 116.8 In-house 8-272 (278) alignment 
Range on Protein: 160-313
Range on HMM: 8-272/278.0
GCSSCSTPLYDQGGPVEILPFLYLGSAY-----------------------------------------HASRKDMLDALGITALINVS-----------
 ...    |. .| | ||.|.||||...                                         .|.  .||  ||||.....            
dlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekca

-----------------------------------------ANCPNHFEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKN--------------AGG
                                         .......  |..|...|  . .  .|...| |...||..  .               ||
qywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsgg

RVFVHCQAGISRSATICLAYLMRTN---RVKLDEAFEFVKQRRSI-ISPNFSFMGQLLQFESQVL
.|.|||.||..|..|...||||...   .| |.||.......| . . .|.... .| .|. ..|
pvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllell
0044763 (Phosphotyrosine protein) phosphatases II 164-312 5.9e-46 151.6 In-house 13-170 (178) alignment 
Range on Protein: 164-312
Range on HMM: 13-170/178.0
CSTPLYDQGGPVEILPFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGH---------YQYKSIPVEDNHKADISSWFNEAIDFIDSIK-NAGGR
  .. .|. ...||||.|||||...|. ...| .||||...|.. .....|...         .||. ||..|..  |....| |...||...  . ||.
eglersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggp

VFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSiISPNFSFMGQLLQFESQV
|.|||.||..||.|...||||..... |.||.|.|..||. |.||.... ||..||...
vlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrl
0046846 (Phosphotyrosine protein) phosphatases II 167-312 3.1e-33 110.4 In-house 5-172 (176) alignment 
Range on Protein: 167-312
Range on HMM: 5-172/176.0
PLYDQGGPVEILPFLYLGSAY----------HASRKDMLDALGITALINVSANC-----------PNHFEGHYQYKSIPVEDNHKADIsSWFNEAIDFID
.|........|.. |.|||..          .|.  .||  |||||..|.               |   . ..||. .|..|..  |. ... |...||.
llgldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefir

SIKNAGGRVFVHCQAGISRSATICLAYLMRT-NRVKLDEAFEFVKQRRS-IISPNFSFMGQLLQFESQV
.  ..||.| |||.|||.|..|...|||... . ....||...|...|.  . ...... .| .|| ..
ealkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll
0041856 (Phosphotyrosine protein) phosphatases II 169-310 2.5e-36 120.3 In-house 14-170 (182) alignment 
Range on Protein: 169-310
Range on HMM: 14-170/182.0
YDQGGPVEILPFLYLGSAYH--------------ASRKDMLDALGITALINVSanCPNHFEGHY-----QYKSIPVEDNHKADisswFNEAIDFIDSIKN
.   .. .|.. ||||| ..              |.  .||  ||||...|..  .....  ..     ||. .|..|..  |    ..|..|||. ...
dhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd....ldelldfieevle

AGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRS--IISPNFSFMGQLLQFES
 ||.|.||| ||..|..|...||||....| |.||...|..||.  .|.||. |. ||. .| 
eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallel
0037934 (Phosphotyrosine protein) phosphatases II 171-311 1.5e-30 101.9 In-house 36-240 (243) alignment 
Range on Protein: 171-311
Range on HMM: 36-240/243.0
QGGPVEILPFLYLGSA--------YHASRKDMLDALGITALINVSANC---------------------------------------------PNHFEGH
 .. ....| |.....        ..||  .||  ||||.....   .                                             ....  .
nanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlv

YQYKSIPVED----NHKADISSWFNEAIDFIDS-----IKNAGGRVFVHCQAGISRSATICLAYLMRTN-RVKLDEAFEFVKQRRSI-ISPNFSFMGQLL
..|  .|. |    .. .|. ....|...||..       . ||.| ||| ||..|..|...|||| .. .| |.||.......|.  . ...|.. .| 
ihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrfly

QFESQ
... .
ealle
subfamily_DSP8_pd Subfamily DSP8 172-312 1.6e-47 155.0 In-house 13-154 (159) alignment 
Range on Protein: 172-312
Range on HMM: 13-154/159.0
GGPVEILPFLYLGSAYHASRKDMLDALGITALINVSANCPNH-FEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICL
 || .||..|||||  ..  ...|..|||.  .|.| .||.  .  . ..  .||.|... ... ||.....||| .|.. |||.||. ||||||||. .
vgptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvai

AYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQV
||.|.| ...||||..|||..|  ||||. |.||||..| ..
ayimktlemsldeayrfvkekrptispnlnflgqLleyekel
0048076 (Phosphotyrosine protein) phosphatases II 172-312 1.1e-40 133.9 In-house 2-142 (145) alignment 
Range on Protein: 172-312
Range on HMM: 2-142/145.0
GGPVEILPFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLA
..| |||| ||||| ..|.. ..|  ||||...|.. ....... ..||  .|..|..  |..... |...||... ..||.|.|||.||..|..|...|
ywpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaa

YLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQV
|||....| |.||.|.|...|... ||.... .|..|| ..
ylmlllgvsleealelvrsqrpgavpnpgqlrflyefelel
subfamily_DSP6_pd Subfamily DSP6 173-312 5.5e-54 176.0 In-house 13-154 (158) alignment 
Range on Protein: 173-312
Range on HMM: 13-154/158.0
GPVEILPFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGH--YQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICL
 ||||||.|||||| .||  ..|. |.|  ..||  | || || .   .|. ||.||.........| |||.|||  ...   |.||| |||||| |..|
fpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtl

AYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQV
||||... . |..|...||.|.| |||||.||||||.||...
aylmkklalslndaydlvkkrksnisPnfnfmgqlldfersl
0048179 (Phosphotyrosine protein) phosphatases II 173-311 3.4e-39 129.2 In-house 3-143 (144) alignment 
Range on Protein: 173-311
Range on HMM: 3-143/144.0
GPVEILPFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHY--QYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICL
 |.|||| ||||| ..|.. ..| .||||..||.. .....|....  ||  .|..|..  |......|...||... . ||.|.|||.||..|..|...
npseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlva

AYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQ
||||..... |.||...|..||... ||.... .||..|..
aylmkklglsleealalvrsrrpgavpnpgqlrfLleyekl
0043147 (Phosphotyrosine protein) phosphatases II 173-313 1.5e-37 124.3 In-house 18-161 (172) alignment 
Range on Protein: 173-313
Range on HMM: 18-161/172.0
GPVEILPFLYLGSAYHASRKDMLDALGITALINVSAN---CPNHFEGHYQYKSIPVEDNHKAdISSWFNEAIDFIDS--IKNAGGRVFVHCQAGISRSAT
 | .......... ..|.  .||  ||||...|.      ... ..  .||  .|..|..   ..... |...|||.  ... ||.| ||| ||..|..|
ipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgt

ICLAYLMRtNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQVL
...||||.  ...|.||...|...|.....|.|.. .|..||...|
lvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfeklll
0036282 (Phosphotyrosine protein) phosphatases II 173-311 5.1e-31 103.1 In-house 11-168 (174) alignment 
Range on Protein: 173-311
Range on HMM: 11-168/174.0
GPVEILPFLYLGSAYHAsRKDMLDALGITALINVSANCPNH---------------FEGHYQYKSIPVEDNHKADISSwFNEAIDFIDSIKNA--GGRVF
. ..|.| |..|.. .|   .||  ||||.....   ....                . ..||. .|..|..  |.|  . |...|.... .   || | 
dlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvl

VHCQAGISRSATICLAYLMRTNRV-KLDEAFEFVKQRR---SIISPNFSFMGQLLQFESQ
||| ||..|..|...|||| ..   .|..|...|...|   . . ...|.. .| .||..
VHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekl
subfamily_MSG5_pd Subfamily MSG5 173-311 3.7e-17 55.9 In-house 25-159 (165) alignment 
Range on Protein: 173-311
Range on HMM: 25-159/165.0
GPVEILPflylGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAY
||. .||       |  |   . . | .  .|||. . ..        |   .| .|.. |   ...    | . .  . ...|||| |.||||.. .||
gpllvlp....eklylysepklkellsfdlvinvakeindlellvpavkyyhiewehdskivkdlsrltriihaatskrkkilvhcqcglsrsaslivay

LMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQ
.|.   . | .|.. .| .   |||.. .. ||...|  
imkyynlslrdaydklksvaddispsiglifqlmeweva
subfamily_DSP10_pd Subfamily DSP10 174-312 3e-55 180.4 In-house 14-153 (159) alignment 
Range on Protein: 174-312
Range on HMM: 14-153/159.0
PVEILPFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEG-HYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAY
 ...||||.|||.  |. .|.|| |.|||..|| ...||.||. . .|| |||.|..| ...  |.||..||. ... | ||.||||||||||||. .||
asqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaY

LMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQV
||.  ...| .|..|||..|.|||||..||||||.|| ..
lmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekel
PTPc_motif_SM00404 174-310 9.6e-51 166.3 In-house 2-139 (140) alignment 
Range on Protein: 174-310
Range on HMM: 2-139/140.0
PVEILPFLYLGSAYHASRKDMLDALGITALINVSANCPN-HFEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAY
| .||| |||||...|.....|..||||. |||. ....   . ..|...||..||.|...| ......|||..... ||.|.||||||.|||||...||
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

LMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFES
|||.. ..|.||.||||.||.|||||..|. ||...| 
lmryrqlslaeayefvkerRpiispnlnfvrqLieyek
subfamily_Slingshot_pd Subfamily Slingshot 174-313 1.5e-39 129.1 In-house 19-158 (169) alignment 
Range on Protein: 174-313
Range on HMM: 19-158/169.0
PVEILPFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYL
. .|  ..|||| . ||  . |.  |.. ..||. .. |.|.....|. | | |....|. ...||. .||.  |..| .|.|||. |.||||.. .|| 
askifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviaya

MRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQVL
|.. ...|.||.|.||.|||.| || .|. || ..|  . 
mkeyglsleealeyvkerrsvikPnkgflkqleeyeGile
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 174-310 2.8e-36 118.2 In-house 7-145 (148) alignment 
Range on Protein: 174-310
Range on HMM: 7-145/148.0
PVEILP-FLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQ-YKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLA
| || . ||.|||  .|.  ..| |||.|...| .....| .. .   |  ....|. | |.|. |...|.|..  |..|.|| ||.| |.|||. . |.
pseikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalall

YLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFES
.|....|| | ||...||..|  . ||  |. || ..| 
wlidfkrvslkealalvkskrryvdpnlgfLkqLaeleq
subfamily_LRR-DSP_pd Subfamily LRR-DSP 174-312 1.3e-35 116.8 In-house 120-258 (263) alignment 
Range on Protein: 174-312
Range on HMM: 120-258/263.0
PVEILPFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSI-PVEDNHKADISSWFNEAIDFIDSIKNAGGrVFVHCQAGISRSATICLAY
| ||.. |.||.   |  | .|  ||.| ..   |..   |   ..| ||  .||  .|||| .|.|   ||.. .. || |.|||.||.|||.|. ..|
PdeiidklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGvsrsstlvisy

LMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQV
||. .|.|. ||...|...|. | ||  |. ||...| ..
lmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekkl
0049260 (Phosphotyrosine protein) phosphatases II 174-310 3.4e-34 113.1 In-house 8-147 (152) alignment 
Range on Protein: 174-310
Range on HMM: 8-147/152.0
PVEILPFLYLGSAYHASRKDMLDALGITALINVSANCPNH---FEGHYQYKSIPVEDNHKADISSWFNEAIDFIDS-IKNAGGRVFVHCQAGISRSATIC
| |.......|.  .|. ..||  ||||.....   ....   .| ..||. .|..|..  |.| .. ....||.  ... ||.|.||| ||..|..|..
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlv

LAYLMRtNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFES
.||||. ..|.|.||...|...|... ||.... .|..||.
aaylml.lgvsleeavalvrekRpgavpnpgqlrflyefek
subfamily_STYXL1_pd Subfamily STYXL1 174-313 2.5e-29 95.5 In-house 11-154 (157) alignment 
Range on Protein: 174-313
Range on HMM: 11-154/157.0
PVEILP-FLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQ---YKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATIC
|||.|| .||||   .|  . .   | . | .||| .. . ..|  .      |.|||. .||. . ..||..||.. |. |  |.|  . ||||||.. 
PvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaavi

LAYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQVL
.||||  ....| .|....|. .. . || .|. || ..| |.|
iaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekqll
subfamily_DSP14_pd Subfamily DSP14 175-313 1.4e-44 145.8 In-house 8-145 (157) alignment 
Range on Protein: 175-313
Range on HMM: 8-145/157.0
VEILPFLYLGsAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLM
..| | |.|. .. |..|..|.. .||. |||. . ||.   . ..  .|||||..|.....|.|..| |...|..||.. ||| ||.||||..||||||
sqitpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylm

RTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQVL
..... | ||.. ||..|.||.||  |  || ..|... 
kyeklsLreayklvksaRpiirPNvGFwkqlidyEkklk
0040439 (Phosphotyrosine protein) phosphatases II 175-311 1.6e-30 102.0 In-house 30-244 (249) alignment 
Range on Protein: 175-311
Range on HMM: 30-244/249.0
VEILPFLYLGSAYHASRKD------------------------MLDALGITALINVSANCPN--------------------------------------
..||| |.|.. ..||  |                        ||  ||||......  ...                                      
lsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtl

-----HFEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKN------AGGRVFVHCQAGISRSATICLAYLM-----RTNRVKLDEAFEFVKQRRSIIS
      .  ..... |.. | .  .....|....|||. ...       ||.|.||| ||..|..|...||||     ....| |.||.......|. . 
eltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgav

PNFSFMGQLLQFESQ
.|.... .|.... .
qnpeqyrflyealle
subfamily_DSP19_pd Subfamily DSP19 176-312 4.8e-44 144.3 In-house 14-150 (152) alignment 
Range on Protein: 176-312
Range on HMM: 14-150/152.0
EILPFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMR
|. | |||||   |. |..|.  .|| ..||... ||.|  ...|.||.. |. ..|..|...||.|||.. ... |.|.|||.||.||||.. .||||.
eveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmk

TNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQV
.....| ||.| |.. |  |.||  |. || ..|...
keelsleealelvrearpcikPneGFikqLkeyeael
subfamily_DSP12_pd Subfamily DSP12 176-310 6.8e-38 124.5 In-house 4-141 (155) alignment 
Range on Protein: 176-310
Range on HMM: 4-141/155.0
EILPFLYLGSAYHASRKDMLDALGITALINVSANC-PNH--FEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAY
.||| ||||.. .. ....|. |.||... |  .  |.|   .|. ..|.|.. |. ..|| |...||.|||..  . .| |.||||||.|||.||..||
rilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAY

LMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFES
||......|..|...||. .. |.|| .|. ||  || 
lmkkeklslekAlklvkekkpeiepNegFleQLklfek
subfamily_DSP15_pd Subfamily DSP15 176-312 6.1e-35 114.5 In-house 4-139 (151) alignment 
Range on Protein: 176-312
Range on HMM: 4-139/151.0
EILPFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGhYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMR
..|| ||||    .. ...|.   || ...|. |  ....   .|| |...|  .|..|..|.|...|| . .  .. |.||| ||.|||.|.. |||| 
kvlpglylgnfrdskdeelLkeknithilsvhdnakkllkd.ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmt

TNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQV
   ..  .|.|..|..||.  ||| |  || ..| . 
vtelnwrdalevikaaRsvanPnfGfkrqlkeyektk
subfamily_DSP3_pd Subfamily DSP3 176-312 4.6e-34 111.4 In-house 13-157 (162) alignment 
Range on Protein: 176-312
Range on HMM: 13-157/162.0
EILPFLYLGSAYHASRKDMLDALGITALINVSANC-------PNHFE-GHYQYKSIPVEDNHKADISSWFNEAIDFIDS-IKNAGGRVFVHCQAGISRSA
|. | ||.| .. |. |. | .|||| ..| ..         .....  . .|  ..|.|. ..|.| .|..| .|||. ...  |.|.|||..|.||||
evypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsa

TICLAYLMRTNRVKLDEAFEFVKQRRSIiSPNFSFMGQLLQFESQV
|. ||||| .....| || . |...|.|  ||  |. || ......
tlvlayLmirrkmtlveairtvrkkRei.lPneGFlkqLaeldeel
0042113 (Phosphotyrosine protein) phosphatases II 176-311 5e-29 96.8 In-house 49-241 (245) alignment 
Range on Protein: 176-311
Range on HMM: 49-241/245.0
EILPFLYLGSAYHASRKD----MLDALGITALINVS------------------------------------------------ANCPNHFEGHYQYKSI
.| | ...... ...  .    ||  ||||......                                                 . . ..  ||.| ..
ritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpw

PveDNHKADISSWFNEAIDFIDSIKN--AGGRVFVHCQAGISRSATICLAYLM-----RTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQ
|  |.. .|..... ....|.... .  ..|.|.||| ||..|..|...||||     .. .| |.||.......|. . ...|.. .| ... .
p..dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_STYX_pd Subfamily STYX 176-314 4.2e-28 91.5 In-house 14-159 (166) alignment 
Range on Protein: 176-314
Range on HMM: 14-159/166.0
EILPFLYLGS--AYHASRKDMLDALGITALINVSANCP-----NHFEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATI
|||| |.||   |   |. ..|   ||| .. .  |         |. ...|  . | ||   .|  .. .  .|||.  . ||.|.|| .|||||||..
eilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaal

CLAYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQVLA
 .||.| |  .|  ||| .|..||  |.||  |. || ..|.  ||
viayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiyla
0051082 (Phosphotyrosine protein) phosphatases II 176-307 6.1e-26 86.2 In-house 10-148 (151) alignment 
Range on Protein: 176-307
Range on HMM: 10-148/151.0
EILPFLYLGSAYHASRKDMLDALGITALINVSA-----NCPNHFEG-HYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNA-GGRVFVHCQAGISRSATI
 . ..||.... .|   ..|  |||.. .|.       .||. ..    ... ||..|..  ... .|.....|.. . .  .| |.||| ||..|..|.
yvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtl

CLAYLMRtNRVKLDEAFEFVKQRRS-IISPNFSFMGQLLQ
...|||   .| |.||.|.....|  .. ||  |. ||..
valylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfa
0036941 (Phosphotyrosine protein) phosphatases II 176-312 3.1e-24 81.3 In-house 21-276 (297) alignment 
Range on Protein: 176-312
Range on HMM: 21-276/297.0
EILPFLYLGSAYHASRKD----------------------------------------------------------MLDALGITALINVSAN--------
|.||.|.||| ..|....                                                          |.  ...| .....          
ellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekc

--------------------------------------------CPNHFEGHYQYKSIPvednhKADISSWFNEAIDFIDSIKN------AGGRVFVHCQ
                                             . ..  |..|...|       .. ..... .|||. ...       ||.| ||| 
aqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwp.....dhgvpespaslldfielvrkvlkllpsggpvlVHCs

AGISRSATICLAYLM--------RTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQV
||..||.|...|.||        ....| . ||. .....|  . ...... .| ... . 
aGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallel
0045450 (Phosphotyrosine protein) phosphatases II 178-311 1e-28 96.4 In-house 94-302 (307) alignment 
Range on Protein: 178-311
Range on HMM: 94-302/307.0
LPFLYLGSAYHASRK----------------DMLDALGITALINVSANCPN-----------------------------HfEGHYQYKSIPVEDN----
.|.|.|.. |. .||                 ||  .|.|......  ...                             | ...|..  ..|.|.    
vpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtg

-------------HKADISSWFNEAIDFIDSIKN------AGGRVFVHCQAGISRSATICLAYLMRTNR--------VKLDEAFEFVKQRRSIISPNFSF
                .....|.|..|||. ...       ||.| ||| ||..|..|...|||| ...        | |.||.......|. . .|...
esrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeq

MGQLLQFESQ
. .| ... .
yrflyealle
0051429 (Phosphotyrosine protein) phosphatases II 179-322 1.5e-21 72.7 In-house 21-234 (272) alignment 
Range on Protein: 179-322
Range on HMM: 21-234/272.0
PF-LYLGSAY---HASRKDMLDALGITALINVSANCPNHFEG------HYQYKSIPVEDNHKADISSWF-------------------------------
|  ||....     |   . |  |||.. ...   .   ...      . .|  .|..|..  .|. ..                               
pgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagear

-----------------NEAIDFIDSIKNaGGRVFVHCQAGISRSATICLAYLMRtNRVK--------------LDEAFEFVKQRRSIISPNFSFMGQLL
                 .. ..... . . ||.| ||| ||..|..|.....|.   .|               |.|| | ....|  . ..  .. .|.
evmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylfly

QFESQVLAPHCSAEAG
... ..| .. |..| 
eallellrsllsvrae
subfamily_MKPLT_pd Subfamily MKPLT 180-313 1.4e-36 119.5 In-house 28-161 (164) alignment 
Range on Protein: 180-313
Range on HMM: 28-161/164.0
FLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRV
 |||| | ||  . .|..| ||  .||| .. . |    .|  . |||. .  .||... | .|. .  ..||||.|||. | |||... .|.|.. .. 
tlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgw

KLDEAFEFVKQRRSIISPNFSFMGQLLQFESQVL
 |.||.|..|.||||..||  |. || .||  .|
tlkeayeylkerrsivapnrGflkqlakfeelil
subfamily_MKPLV_pd Subfamily MKPLV 180-313 1.4e-36 119.5 In-house 28-161 (164) alignment 
Range on Protein: 180-313
Range on HMM: 28-161/164.0
FLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRV
 |||| | ||  . .|..| ||  .||| .. . |    .|  . |||. .  .||... | .|. .  ..||||.|||. | |||... .|.|.. .. 
tlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgw

KLDEAFEFVKQRRSIISPNFSFMGQLLQFESQVL
 |.||.|..|.||||..||  |. || .||  .|
tlkeayeylkerrsivapnrGflkqlakfeelil
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 180-312 6.5e-27 87.8 In-house 9-152 (154) alignment 
Range on Protein: 180-312
Range on HMM: 9-152/154.0
FLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGH---------YQYKSIPVEDNHKADISSWFNEAIDFIDSIK--NAGGRVFVHCQAGISRSATI
|||..|   |  |  |.   |. ..||.   .| |  .         ..|  . . |. . ||   .. | .|||.       ..|.||...|.||||..
flyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaal

CLAYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQV
 ..|||   .. | .|.|..|. | ||.||  |. || .|| . 
lisylmdklkislslalellkdsryiikPnqGflkqleifekel
DSPc Dual specificity phosphatase, catalytic domain 181-310 2.5e-49 161.6 Pfam-A 1-132 (133) alignment 
Range on Protein: 181-310
Range on HMM: 1-132/133.0
LYLGSAYHASrKDMLDALGITALINVSANCPN-HF--EGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTN
|||||...|| ...|..||||. |||. ..|| ..  .....| .|||||.....||....||..||..... |..|.||||||||||||...||||.|.
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

RVKLDEAFEFVKQRRSIISPNFSFMGQLLQFES
...|.||.||||.|||.||||..|..|||..|.
nlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 181-310 2.5e-49 161.6 In-house 1-132 (133) alignment 
Range on Protein: 181-310
Range on HMM: 1-132/133.0
LYLGSAYHASrKDMLDALGITALINVSANCPN-HF--EGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTN
|||||...|| ...|..||||. |||. ..|| ..  .....| .|||||.....||....||..||..... |..|.||||||||||||...||||.|.
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

RVKLDEAFEFVKQRRSIISPNFSFMGQLLQFES
...|.||.||||.|||.||||..|..|||..|.
nlslneAyefvkerrskispnagflrqLleyer
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 181-312 1e-26 86.8 In-house 6-141 (145) alignment 
Range on Protein: 181-312
Range on HMM: 6-141/145.0
LYLGSAYHASRKDMLDALGITALINVSANCP----NHFEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRT
|| ||| ||.   .|. |||. ..|..|       .    ...   |  || .  |.|  |.|  ||||  |. |  ||||| ||.||| |. .|.||. 
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

NRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQV
  . | ||   |. .|    ||  |. .||..| |.
cnmtlseaarqvrsnrllaypnvtflknllnlekql
0039614 (Phosphotyrosine protein) phosphatases II 194-312 4.8e-25 84.1 In-house 120-288 (297) alignment 
Range on Protein: 194-312
Range on HMM: 120-288/297.0
MLDALGITALINVSANCPN--------------------------------------------HFEGHYQYKSIPveDNHKADISSWFNEAIDFIDSIKN
|.  .|.|.....   ...                                            ..  |.|| ..|  |..  .... . |........ .
mvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwp..dhgvppslellleflelvreala

---AGGRVFVHCQAGISRSATICLAYLM-----RTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQV
    ||.| ||| ||..|..|...||||     .. .| ..||.......|. . ...|.. .| ... . 
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel
0040438 (Phosphotyrosine protein) phosphatases II 194-311 2.1e-24 81.8 In-house 105-274 (317) alignment 
Range on Protein: 194-311
Range on HMM: 105-274/317.0
MLDALGITALINVSANCPNH---------------------------FEGHYQYKSIPVEDN----------------HKADISSWFNEAIDFIDSIKNA
|.  .|.| ....   ...                             ......  ..|||.                   .. ..... .||.. ...|
mvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrea

----GGRVFVHCQAGISRSATICLAYLM-----RTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQ
    || | ||| ||..|..|...||||     ....| ..||.......|. . ...... .| ... .
ledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalle
subfamily_DSP23_pd Subfamily DSP23 194-292 7.2e-07 24.0 In-house 26-125 (148) alignment 
Range on Protein: 194-292
Range on HMM: 26-125/148.0
MLDALGITALINVSANCPNHFEGHY--QYKSIPVEDNHKADiSSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQR
.|  ||.  |. .. ... | |      .. . ..| |        .| .  ..  .. .  | |||  |  |. |.   ||.. ...   ||   |...
ylldlgvrylvslteegrphveatpnltlvrlriddyhppa.leqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrl

R
|
r
0049772 (Phosphotyrosine protein) phosphatases II 195-312 2.6e-35 118.0 In-house 158-273 (314) alignment 
Range on Protein: 195-312
Range on HMM: 158-273/314.0
LDALGITALInvsANC--PNHFEGH-YQYKSIPVEDnHKADISSWFNEAIDFIDSIkNAGGRVFVHCQAGISRSAT-ICLAYLMRTNRVKLDEAFEFVKQ
..|  .  |      .  |..||.. ..|. |||.| . |.....|.|...||..  ..||.|.|||.||..|..| ...||||. ..| |.||.|.|..
ptaadlellk...eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrl

RRSiISPNFSFMGQLLQFESQV
.|. |.||..|. ||.|.| . 
kRp.inpnpgfieqleqyefil
0043336 (Phosphotyrosine protein) phosphatases II 200-309 1.6e-21 72.5 In-house 113-273 (278) alignment 
Range on Protein: 200-309
Range on HMM: 113-273/278.0
ITALINVS-----------------------------------------------ANCPNHFEGHYQYKSIPveDNHKA-DISSWFNEAIDFIDSIKNAG
.| ....                                                 . . ..  ||.|...|  |..   ..|. ..   .... ... .
vttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp..dhgvpeslsllldflkavrealedsn

GRVFVHCQAGISRSATICLAYLM-----RTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFE
| | ||| ||..|..|....||.     .. .| |.||.......|  . ...|.. .| ...
gpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 208-293 8.8e-06 19.9 In-house 151-236 (267) alignment 
Range on Protein: 208-293
Range on HMM: 151-236/267.0
ANCPNHFEGHYQYKSIPVEDNHKADISSWFNeaIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLM--RTNRVKLDEAFEFVKQRRS
 |   |    | ||   .. | |  .   |   |   . ..|..  . |.|..|. || |   .. .  |. .    . |.|... ||
knesahnvtlyyykkwnintnnkpylkplfg..ilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirs
0046845 (Phosphotyrosine protein) phosphatases II 210-299 2.6e-14 48.8 In-house 162-260 (284) alignment 
Range on Protein: 210-299
Range on HMM: 162-260/284.0
CPNHFEGHYQYKSIPveDNHKADISSWFNEAIDFIDSIKNA---GGRVFVHCQAGISRSATICLAYLMRTN--------RVKLDEAFEFVKQRRSIISPN
 . ..  |..|.|.|  |..  . .... | ....... ..   || . ||| ||..|..|.....|. .         .| . ||. .....|     .
gesrtvthfhytswp..dhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqt

F
.
l
0038934 (Phosphotyrosine protein) phosphatases II 211-313 4.1e-21 71.0 In-house 72-177 (194) alignment 
Range on Protein: 211-313
Range on HMM: 72-177/194.0
PNHFEGH-YQYKSIPVEDNHKADISSWFNEAIDFIDSIKNA--GGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQ
|..||.. ..| ..|..| . .   .  .. .|..| . |.  || | ||| ||..|..|.. |||. ... ...|| ......|  . || ... .||.
peefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallk

FESQVL
. ... 
rykelr
DSPc_SM00195 211-275 8.7e-07 23.9 In-house 156-219 (263) alignment 
Range on Protein: 211-275
Range on HMM: 156-219/263.0
PNHFEGHYQYKSIPVEdnHKADISSWFNEAIDFIDSIKN-AGGRVFVHCQAGISRSATICLAYLMR
 ...  .||||. | .     |  . . | . .... |.   | . |||.||..|..|.... .. 
etrkvtqyqyknWpdh..gvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiil
PTPc_SM00194 211-275 8.7e-07 23.9 In-house 156-219 (263) alignment 
Range on Protein: 211-275
Range on HMM: 156-219/263.0
PNHFEGHYQYKSIPVEdnHKADISSWFNEAIDFIDSIKN-AGGRVFVHCQAGISRSATICLAYLMR
 ...  .||||. | .     |  . . | . .... |.   | . |||.||..|..|.... .. 
etrkvtqyqyknWpdh..gvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiil
0047943 (Phosphotyrosine protein) phosphatases II 212-307 7.5e-18 60.4 In-house 165-266 (273) alignment 
Range on Protein: 212-307
Range on HMM: 165-266/273.0
NHFEGHYQYKSIPveDNHKADISSWFNEAIDFIDSIKN---AGGRVFVHCQAGISRSATICLAYLM-----RTNRVKLDEAFEFVKQRRSIISPNFSFMG
 ..  |..|...|  |..  .  . . | |...... .    .| | ||| ||..|..|.....|.     ....| ..||. .....|  . ...... 
srtvthfhytgwp..dhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyr

QLLQ
.| .
flye
0051299 (Phosphotyrosine protein) phosphatases II 213-300 3.9e-16 54.8 In-house 182-273 (288) alignment 
Range on Protein: 213-300
Range on HMM: 182-273/288.0
HFEGHYQYKSIPvEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLM-----RTNRVKLDEAFEFVKQRRSIISPNFS
..  |..|...| ...   .......   ........ || | ||| ||..|..|.....|.     ....| . ||.......|  . ....
rtvthfhytnwp.dhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpe
0050432 (Phosphotyrosine protein) phosphatases II 213-299 1.8e-14 49.3 In-house 197-285 (308) alignment 
Range on Protein: 213-299
Range on HMM: 197-285/308.0
HFEGHYQYKSIPveDNHKADIsswFNEAIDFIDSIKNA--GGRVFVHCQAGISRSATICLAYLM-----RTNRVKLDEAFEFVKQRRSIISPNF
..  |..|.. |  | .  .    ... .||.. ...   || . ||| ||..|..|.....|.     ....| . ||. .....|    ...
rtvthfhytnWp..dhgvPps...peilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp
Y_phosphatase Protein-tyrosine phosphatase 213-289 1.5e-07 26.5 Pfam-A 134-210 (235) alignment 
Range on Protein: 213-289
Range on HMM: 134-210/235.0
HFeGHYQYKSIPvEDNHKADisswFNEAIDFIDSIKNAG----GRVFVHCQAGISRSATICLAYLMRTNRVK--LDEAFEFVK
..  ...|.. | . . ...     .. .|.|.....      | | ||| ||..|..|.... ..  .  .    . ...||
ev.kqlhytnWp.dhgvpes....pkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivk
Y_phosphatase Protein-tyrosine phosphatase 213-289 1.5e-07 26.5 In-house 134-210 (235) alignment 
Range on Protein: 213-289
Range on HMM: 134-210/235.0
HFeGHYQYKSIPvEDNHKADisswFNEAIDFIDSIKNAG----GRVFVHCQAGISRSATICLAYLMRTNRVK--LDEAFEFVK
..  ...|.. | . . ...     .. .|.|.....      | | ||| ||..|..|.... ..  .  .    . ...||
ev.kqlhytnWp.dhgvpes....pkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivk
PTPc_DSPc_SM00012 217-292 2e-09 33.0 In-house 4-83 (105) alignment 
Range on Protein: 217-292
Range on HMM: 4-83/105.0
HYQYKSIPVEdnHKADISswfNEAIDFIDSIKNAGG------RVFVHCQAGISRSATICLAYLMRTNRVK---LDEAFEFVKQRR
||.|...| .  .. . |   .. .......|.          | |||.||..|..|.......  .  |    .. |..||. |
hyhytgwpdh..gvPees...dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelr
subfamily_PTPMT1_pd Subfamily PTPMT1 219-311 3.9e-20 67.0 In-house 75-167 (171) alignment 
Range on Protein: 219-311
Range on HMM: 75-167/171.0
QYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQ
.. .... |  .|      .....||..... | ||.|||.|| .||||.  .||| .......|| ...|..|.||  .   . .| ..|..
eqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeek
subfamily_Laforin_pd Subfamily Laforin 220-292 3.9e-07 23.1 In-house 79-151 (183) alignment 
Range on Protein: 220-292
Range on HMM: 79-151/183.0
YKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRR
|  .|.||         . .|. .. .. . | .|.|||.||. ||..|   .|.     .|     |.  .|
yiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakr
subfamily_PTEN_pd Subfamily PTEN 222-293 4.6e-06 21.7 In-house 84-157 (184) alignment 
Range on Protein: 222-293
Range on HMM: 84-157/184.0
SIPVEDNHKADISsWFNEAIDFIDS-IKNAGGR-VFVHCQAGISRSATICLAYLMRTNRVKLD-EAFEFVKQRRS
 .|..|.. . ..  ..|... |.. ...   . | |||.||  |. ..  |||. .. ..   || |. .. |.
vypfdDhnppple.lleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRt
subfamily_DSP11_pd Subfamily DSP11 228-292 8.2e-06 19.8 In-house 92-157 (178) alignment 
Range on Protein: 228-292
Range on HMM: 92-157/178.0
NHKADISSWFNEAI-DFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRR
  | .. . |.||. .|... |. .  . |||  |. |.  .   ||. .. .. ..| |  .. |
vpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeear
0048567 (Phosphotyrosine protein) phosphatases II 229-301 5.6e-10 33.8 In-house 52-129 (157) alignment 
Range on Protein: 229-301
Range on HMM: 52-129/157.0
HKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGI---SRSATICLAYLMRTNRVKLDEAFEFVKQRR--SIISPNFSF
. | . .... . .|......||... ||| ||    .|.||.. .||.  ..   .||...... |  |.. .  |.
nlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasy
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 239-272 6.5e-06 20.5 In-house 179-215 (290) alignment 
Range on Protein: 239-272
Range on HMM: 179-215/290.0
EAIDFIDSIKNAGGRVFVHCQAGISRSATIC---LAY
 ... |. .|. .  | |||. ||||||..    |.|
tllsliqkvkasktpvivHcvdGiSrsAalaaiilgy
subfamily_CDC14_pd Subfamily CDC14 242-302 1.8e-08 28.6 In-house 254-316 (328) alignment 
Range on Protein: 242-302
Range on HMM: 254-316/328.0
DFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRR--SIISPNFSFM
 |.. ...| | . |||.||. |  |.  .|||.. |.   ||  ...  |  |.|.|  .|.
kfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGsvigpqqkfl
subfamily_PTPDC1_pd Subfamily PTPDC1 249-293 2.6e-07 25.2 In-house 113-156 (182) alignment 
Range on Protein: 249-293
Range on HMM: 113-156/182.0
NAGgRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRS
. | .| ||| ||  |   .  .||. ..|.. ..| ..|...|.
qeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrp