Gene DUSP5 in Homo sapiens

Synonym: DUSP, HVH3, DUSP5

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP1
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP012_AA protein Get Run
HsapP012_AA_176-321 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Rhodanese Rhodanese-like domain 13-134 7.5e-09 28.1 Pfam-A 7-112 (113) alignment 
Range on Protein: 13-134
Range on HMM: 7-112/113.0
KMLrkeAAARCVVLDCRPYLAFAASNVRGSLNVNLNSVvlrrarggaVSARYVLPDEAARARLLQEGG--GGVAAVVVLDqgsrhWQKLREESAARVVLT
..|    . ..|.||.|.  ..|.. ..|..||.|.|           . |.   ..     | . |   .    ||| .      .. | . ||...| 
ell...ekekvvllDvRspeeyakghIpgAvnvpldsl.........yprrdlffkdklaeeleesgkkldkdktvvvyc.....rsgnrsggaaallla

SLLACLpAGPRVYFLKGGYETFYS
 .|. |   ..||.|.||.| ...
lilkel.gyknvyvLdGGfeawka
0044763 (Phosphotyrosine protein) phosphatases II 165-319 2.3e-45 149.7 In-house 9-172 (178) alignment 
Range on Protein: 165-319
Range on HMM: 9-172/178.0
VVNVSYRPAYDQGGPVEILPFLYLGSAYHASKCEFLANLHITALLNVSRRTSEA---------CATHLHYKWIPVEDSHTADISSHFQEAIDFIDCVR-E
. |... ...|. ...||||.|||||...|.  |.| .|.||...|..  .              ....|..||..|... |...||.|...||. .. |
lsnleglersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealde

KGGKVLVHCEAGISRSPTICMAYLMKTKQFRLKEAFDYIKQRRSmVSPNFGFMGQLLQYESEILP
|||.||||| ||..||.|...|||||. .. | ||......||. ..||.|.. ||...|...|.
kggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllk
0051429 (Phosphotyrosine protein) phosphatases II 165-318 3.5e-22 74.8 In-house 6-225 (272) alignment 
Range on Protein: 165-318
Range on HMM: 6-225/272.0
VVNVSYRPAYdqggPVEILPF-LYLGSAY---HASKCEFLANLHITALLNVSRRTS------EACATHLHYKWIPVEDSHTADISSHF------------
..|... . |      ...|  ||....     |   ..|..|.|.. ... . .       .  . ...| ..|..|... .|. ..            
yiNardvggy....grvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

------------------------------------QEAIDFIDCVREkGGKVLVHCEAGISRSPTICMAYLMKtKQFR--------------LKEAFDY
                                    .. ..... ... ||.||||| ||..|. |.....|.   ..               | || ..
dyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeavee

IKQRRSMVSPNFGFMGQLLQYESEIL
....|  . .. ... .|.... |.|
lraqrpgavqteeqylflyeallell
subfamily_DSP1_pd Subfamily DSP1 166-319 6.8e-68 221.9 In-house 7-158 (163) alignment 
Range on Protein: 166-319
Range on HMM: 7-158/163.0
VNVSYRPAYDqggPVE-ILPFLYLGSAYHASKCEFLANLHITALLNVSRRTSEACATHLHYKWIPVEDSHTADISSHFQEAIDFIDCVREKGGKVLVHCE
........||   ||| ||.||||||...||..|.|..|.|||.||||....... ....||....|||..||||..|.|.|.|||.|..|.||||.||.
cdldklklyd...PvekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCq

AGISRSPTICMAYLMKTKQFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYESEILP
|||||| |.|.|||||||...|.||||..|||||..|||.||..|||.||...| 
aGisRsstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekklll
PTEN_1 168-319 5.1e-37 122.6 In-house 35-193 (196) alignment 
Range on Protein: 168-319
Range on HMM: 35-193/196.0
VSYRPAYDqggpvEILPFLYLGSAYHA-SKCEFLANLHITALLNVSRRTSE---------ACATHLHYKWIPVEDSHTADISSHFQEAIDFIDCVR--EK
 . || ..     || ..||.||. .. .  . |   .||...|.| .  .         ... .. |. .|.|| .. ..|..| .. .||....  ..
apsrpllq.....eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpn

GGKVLVHCEAGISRSPTICMAYLMKTKQFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYESEILP
|..||||| ||..|| |...||||.....  .||.......|. ..|| ... .||.|..|.| 
gnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaella
0046846 (Phosphotyrosine protein) phosphatases II 170-317 6.3e-36 119.1 In-house 3-172 (176) alignment 
Range on Protein: 170-317
Range on HMM: 3-172/176.0
YRPAYDQGGPVEILPFLYLGSAY----------HASKCEFLANLHITALLNVSRRT-----------SEACATHLHYKWIPVEDSHTADIsSHFQEAIDF
.|. ........|.. |.|||..          .|.  |.| .|.|||..|.  ..           .|  . ...|...|..| .. |. ....|...|
lrllgldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellef

IDCVREKGGKVLVHCEAGISRSPTICMAYLMKT-KQFRLKEAFDYIKQRRS-MVSPNFGFMGQLLQYESEI
|. ....||.||||| |||.|..|...|||... |.. . ||.......|. .. ...... .| ..| ..
irealkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll
0041856 (Phosphotyrosine protein) phosphatases II 171-316 3e-36 120.1 In-house 11-171 (182) alignment 
Range on Protein: 171-316
Range on HMM: 11-171/182.0
RPAYDQGGPVEILPFLYLGSAYH--------------ASKCEFLANLHITALLNVSRRT---SEACATHLHYKWIPVEDSHTADisshFQEAIDFIDCVR
 | .   .. .|.. ||||| ..              |.  ..| .|.||...|.. .    ..   . ..|...|..| .. |    ..|..|||. |.
lpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd....ldelldfieevl

EKGGKVLVHCEAGISRSPTICMAYLMKTKQFRLKEAFDYIKQRRS--MVSPNFGFMGQLLQYESE
|.||.||||| ||..|..|...|||||.... | ||......||.   ..||..|. ||. .|  
eeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallell
0045098 (Phosphotyrosine protein) phosphatases II 175-318 7.5e-33 109.5 In-house 18-272 (278) alignment 
Range on Protein: 175-318
Range on HMM: 18-272/278.0
DQGGPVEILPFLYLGSAY-----------------------------------------HASKCEFLANLHITALLNVS---------------------
 .| | ||.|.||||...                                         .|.  ..| .|.||.....                      
llgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggslt

-------------------------------RRTSEACATHLHYKWIPVEDSHTADISSHFQEAIDFIDCVRE--------------KGGKVLVHCEAGI
                                   ..  |||||...|  .... .|...|.|...||. ...              .||.||||| ||.
ygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGv

SRSPTICMAYLMKTK---QFRLKEAFDYIKQRRSM-VSPNFGFMGQLLQYESEIL
.|. |...||||..    .. | ||.......| . . .|.... .| ... |.|
gRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllell
0037934 (Phosphotyrosine protein) phosphatases II 175-317 6.7e-30 99.8 In-house 35-241 (243) alignment 
Range on Protein: 175-317
Range on HMM: 35-241/243.0
DQGGPVEILPFLYLGSA--------YHASKCEFLANLHITALLNVSRRT---------------------------------------------SEACAT
  .. ....| |.....        ..||  ..| .|.||..... . .                                             .. . .
inanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrl

HLHYKWIPVED----SHTADISSHFQEAIDFIDC-----VREKGGKVLVHCEAGISRSPTICMAYLMKTK-QFRLKEAFDYIKQRRSM-VSPNFGFMGQL
. || ..|. |    ....|. ....|...||.      .. .||.||||| ||..|. |...||||... .. | ||.......|.. . ...... .|
vihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrfl

LQYESEI
 ... |.
yeallel
subfamily_DSP8_pd Subfamily DSP8 177-317 1.6e-42 138.8 In-house 13-154 (159) alignment 
Range on Protein: 177-317
Range on HMM: 13-154/159.0
GGPVEILPFLYLGSAYHASKCEFLANLHITALLNVSRRTSE-ACATHLHYKWIPVEDSHTADISSHFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICM
 || .||..|||||  .. . |.| .| |.  ||.|.   .  . .. ..  .||.|... ...  |.....||| .... |.||||. ||||||.|. .
vgptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvai

AYLMKTKQFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYESEI
||.||| .. | ||. ..|..| ..|||. |.||||.|| |.
ayimktlemsldeayrfvkekrptispnlnflgqLleyekel
0048076 (Phosphotyrosine protein) phosphatases II 177-317 2.8e-41 135.8 In-house 2-142 (145) alignment 
Range on Protein: 177-317
Range on HMM: 2-142/145.0
GGPVEILPFLYLGSAYHASKCEFLANLHITALLNVSRRTSEACATHLHYKWIPVEDSHTADISSHFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMA
..| |||| ||||| ..|.. |.|..|.||..||... ..   .....| ..|..| .. |......|...||. ....||.||||| ||..|..|...|
ywpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaa

YLMKTKQFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYESEI
|||..... | ||.......|... ||.|.. .|...| |.
ylmlllgvsleealelvrsqrpgavpnpgqlrflyefelel
subfamily_DSP6_pd Subfamily DSP6 178-317 4.8e-50 163.1 In-house 13-154 (158) alignment 
Range on Protein: 178-317
Range on HMM: 13-154/158.0
GPVEILPFLYLGSAYHASKCEFLANLHITALLNVSRRTSEAC--ATHLHYKWIPVEDSHTADISSHFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICM
 ||||||.|||||| .||..| |..|.|  .|||     ..   . .|.|. ||.|| ........| |||.|||  |.|  |||||| |||||| |...
fpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtl

AYLMKTKQFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYESEI
|||||.... |..|.|..|.|.| .|||| ||||||..|...
aylmkklalslndaydlvkkrksnisPnfnfmgqlldfersl
subfamily_DSP10_pd Subfamily DSP10 178-317 3.5e-49 160.7 In-house 13-153 (159) alignment 
Range on Protein: 178-317
Range on HMM: 13-153/159.0
GPVEILPFLYLGSAYHASKCEFLANLHITALLNVSRRTSEACAT-HLHYKWIPVEDSHTADISSHFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMA
  ...||||.|||.  |.. . | .|.|||.|||  ..    .  .|.|| |||.|... ... .|.||..||. .|.|| .|||||.|||||| |. .|
pasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvvia

YLMKTKQFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYESEI
|||| ..  |..|....|..|...|||..||||||..| |.
YlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekel
0043147 (Phosphotyrosine protein) phosphatases II 178-317 5.3e-39 129.0 In-house 18-160 (172) alignment 
Range on Protein: 178-317
Range on HMM: 18-160/172.0
GPVEILPFLYLGSAYHASKCEFLANLHITALLNVSRR---TSEACATHLHYKWIPVEDSHTAdISSHFQEAIDFIDC--VREKGGKVLVHCEAGISRSPT
 | .......... ..|.  ..| .|.||...|. ..   ..  . . ..| ..|..| ..  ......|...|||   ....||.||||| ||..|..|
ipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgt

ICMAYLMKtKQFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYESEI
...||||. ... | ||.......|.....|.... .|...|. .
lvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekll
0048179 (Phosphotyrosine protein) phosphatases II 178-315 5.8e-39 128.4 In-house 3-142 (144) alignment 
Range on Protein: 178-315
Range on HMM: 3-142/144.0
GPVEILPFLYLGSAYHASKCEFLANLHITALLNVSRRTSEACATHL--HYKWIPVEDSHTADISSHFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICM
 |.|||| ||||| ..|.. |.|..|.||...|..     .. ..   .| ..|..| .. |......|...||. ..|.||.||||| ||..|..|...
npseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlva

AYLMKTKQFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYES
|||||.... |.||......||... ||.|.. .||.||.
aylmkklglsleealalvrsrrpgavpnpgqlrfLleyek
0036282 (Phosphotyrosine protein) phosphatases II 178-315 1.2e-31 105.1 In-house 11-167 (174) alignment 
Range on Protein: 178-315
Range on HMM: 11-167/174.0
GPVEILPFLYLGSAYHAsKCEFLANLHITALLNVSRRT---------------SEACATHLHYKWIPVEDSHTADISShFQEAIDFIDCVREK--GGKVL
. ..|.| |..|.. .|   |.| .|.||..... .                 .    ....|...|..| .. |.|  ..|...|.. ....  ||.||
dlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvl

VHCEAGISRSPTICMAYLMKTKQF-RLKEAFDYIKQRR---SMVSPNFGFMGQLLQYES
||| ||..|..|...||||.. .. .| .|.|.....|   ... ...... .| ..|.
VHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfek
PTPc_motif_SM00404 179-315 2.9e-45 148.6 In-house 2-139 (140) alignment 
Range on Protein: 179-315
Range on HMM: 2-139/140.0
PVEILPFLYLGSAYHASKCEFLANLHITALLNVSRRTSE-ACATHLHYKWIPVEDSHTADISSHFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMAY
| .||| |||||...|.. ..|..| ||. .||..  |      . ....||..|......| ......|||. ...||||||||| ||.||| |...||
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

LMKTKQFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYES
||...|. |.||....|.||...|||..|. ||..|| 
lmryrqlslaeayefvkerRpiispnlnfvrqLieyek
subfamily_Slingshot_pd Subfamily Slingshot 179-315 6e-36 117.4 In-house 19-155 (169) alignment 
Range on Protein: 179-315
Range on HMM: 19-155/169.0
PVEILPFLYLGSAYHASKCEFLANLHITALLNVSRRTSEACATHLHYKWIPVEDSHTADISSHFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMAYL
. .|  ..|||| . ||. | | .  .. .|||..   .  . ...|. | | |....|. ....|. .||. ...|| ||||||  |.||| .. .|| 
askifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviaya

MKTKQFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYES
||. .. |.||..|.|.|||.. || ||. || .|| 
mkeyglsleealeyvkerrsvikPnkgflkqleeyeG
0049260 (Phosphotyrosine protein) phosphatases II 179-315 3.6e-35 116.3 In-house 8-147 (152) alignment 
Range on Protein: 179-315
Range on HMM: 8-147/152.0
PVEILPFLYLGSAYHASKCEFLANLHITALLNVSRRTS---EACATHLHYKWIPVEDSHTADISSHFQEAIDFIDC-VREKGGKVLVHCEAGISRSPTIC
| |.......|.  .|.  ..| .|.||..... ...    . |. . .|...|..|... |.| .......||..  ..|||.||||| ||..|..|..
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlv

MAYLMKtKQFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYES
.||||. ... |.||.......|... ||.|.. .|...|.
aaylml.lgvsleeavalvrekRpgavpnpgqlrflyefek
subfamily_LRR-DSP_pd Subfamily LRR-DSP 179-317 1.1e-33 110.5 In-house 120-258 (263) alignment 
Range on Protein: 179-317
Range on HMM: 120-258/263.0
PVEILPFLYLGSAYHASKCEFLANLHITAL-LNVSRRtSEACATHLHYKWI-PVEDSHTADISSHFQEAIDFIDCVREKGGkVLVHCEAGISRSPTICMA
| ||.. |.||.   |    .| .| .| . | |.          . |  |  .||   |||| ||.|   ||.  |.||| ||||| ||.||| |. ..
PdeiidklflGgldsannksilkdlgvthillavadf.ePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGvsrsstlvis

YLMKTKQFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYESEI
|||| .....|||.| ....|. . || ||. ||..|| ..
ylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekkl
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 179-315 9.8e-33 106.8 In-house 7-145 (148) alignment 
Range on Protein: 179-315
Range on HMM: 7-145/148.0
PVEILP-FLYLGSAYHASKCEFLANLHITALLNVSRRTSEACATH-LHYKWIPVEDSHTADISSHFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMA
| || . ||.|||  .|.. | |..| .|.. | ..    | . . ..|  ....|    |.|. |...|.|.. ....|..||||.. |.|||  . ..
pseikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalall

YLMKTKQFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYES
.|...|.  ||||....|..| .| || ||. || ..| 
wlidfkrvslkealalvkskrryvdpnlgfLkqLaeleq
subfamily_STYXL1_pd Subfamily STYXL1 179-318 2.3e-30 98.9 In-house 11-154 (157) alignment 
Range on Protein: 179-318
Range on HMM: 11-154/157.0
PVEILP-FLYLGSAYHASKCEFLANLHITALLNVSRRTSEACATHLH---YKWIPVEDSHTADISSHFQEAIDFIDCVREKGGKVLVHCEAGISRSPTIC
|||.|| .||||   .| . .   .| . | .|||  . .  |.  .      |.|||.  ||. ....||..||.  ...|  |||  . ||||| .. 
PvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaavi

MAYLMKTKQFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYESEIL
.||||  |.. ||.|..|.|. .. | || .|. || ..| ..|
iaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekqll
subfamily_DSP14_pd Subfamily DSP14 180-317 9.4e-43 139.9 In-house 8-144 (157) alignment 
Range on Protein: 180-317
Range on HMM: 8-144/157.0
VEILPFLYLGsAYHASKCEFLANLHITALLNVSRRTSEACATHLHYKWIPVEDSHTADISSHFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMAYLM
..| | |.|. .. |.. | |.. .||. .||......  . ....  .||||...|....||.|..| |. |..||||.|||| ||.||| ..|.||||
sqitpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylm

KTKQFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYESEI
|...  |.||. ..|..|....|| ||  || .||...
kyeklsLreayklvksaRpiirPNvGFwkqlidyEkkl
0040439 (Phosphotyrosine protein) phosphatases II 180-317 1.5e-30 102.0 In-house 30-245 (249) alignment 
Range on Protein: 180-317
Range on HMM: 30-245/249.0
VEILPFLYLGSAYHASKCEF------------------------LANLHITALLNVSRRTSE--------------------------------------
..||| |.|.. ..||  ..                        | .|.||....... .                                        
lsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtl

-----ACATHLHYKWIPVEDSHTADISSHFQEAIDFIDCVRE------KGGKVLVHCEAGISRSPTICMAYLM-----KTKQFRLKEAFDYIKQRRSMVS
      . .......|.. | .  .....|....|||. ||.      |||.||||| ||..|..|...||||     |.... |.||.......|... 
eltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgav

PNFGFMGQLLQYESEI
.|.... .|.... |.
qnpeqyrflyeallel
subfamily_DSP19_pd Subfamily DSP19 181-317 1.9e-43 142.4 In-house 14-150 (152) alignment 
Range on Protein: 181-317
Range on HMM: 14-150/152.0
EILPFLYLGSAYHASKCEFLANLHITALLNVSRRTSEACATHLHYKWIPVEDSHTADISSHFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMAYLMK
|. | |||||   |.. | | . .|| .|||.  . .. .....|. |.. |   .|..|...||.|||. .|.| | |||||.||.|||... .|||||
eveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmk

TKQFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYESEI
... .|.||...... |  ..|| ||. || .||.|.
keelsleealelvrearpcikPneGFikqLkeyeael
subfamily_DSP15_pd Subfamily DSP15 181-317 1.7e-38 126.0 In-house 4-139 (151) alignment 
Range on Protein: 181-317
Range on HMM: 4-139/151.0
EILPFLYLGSAYHASKCEFLANLHITALLNVSRrTSEACATHLHYKWIPVEDSHTADISSHFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMAYLMK
..|| ||||    ... | | . .|| .|.|.   .. .  ...|| |...|.  |..|..|.|...|| . | |...||||| ||.||| |...|||| 
kvlpglylgnfrdskdeelLkeknithilsvhd.nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmt

TKQFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYESEI
  ..  ..|.. ||..||.  |||||  || .||   
vtelnwrdalevikaaRsvanPnfGfkrqlkeyektk
subfamily_DSP12_pd Subfamily DSP12 181-315 3.5e-38 125.4 In-house 4-141 (155) alignment 
Range on Protein: 181-315
Range on HMM: 4-141/155.0
EILPFLYLGSAYHASKCEFLANLHITALLNVSRRTS---EACATHLHYKWIPVEDSHTADISSHFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMAY
.||| ||||.. .. . |.|..|.||..| | ...    .. ......| |.. |. ..|| ||..||.|||.  .|..|.|||||.||.||| ||..||
rilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAY

LMKTKQFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYES
|||.... |..|.. .|. .. ..|| ||. ||  .| 
lmkkeklslekAlklvkekkpeiepNegFleQLklfek
subfamily_DSP3_pd Subfamily DSP3 181-317 1.2e-33 110.0 In-house 13-157 (162) alignment 
Range on Protein: 181-317
Range on HMM: 13-157/162.0
EILPFLYLGSAYHASKCEFLANLHITALLNVSRRTS------EA--CATHLHYKWIPVEDSHTADISSHFQEAIDFID-CVREKGGKVLVHCEAGISRSP
|. | ||.| .. |.. . |..| || .|| ..         .     ....|  ..|.|. ..|.| .|..| .|||  . .| |||||||..|.|||.
evypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsa

TICMAYLMKTKQFRLKEAFDYIKQRRsMVSPNFGFMGQLLQYESEI
|. .|||| .... |.||   ....| .. || ||. || ....|.
tlvlayLmirrkmtlveairtvrkkR.eilPneGFlkqLaeldeel
0042113 (Phosphotyrosine protein) phosphatases II 181-316 1.6e-30 101.7 In-house 49-241 (245) alignment 
Range on Protein: 181-316
Range on HMM: 49-241/245.0
EILPFLYLGSAYHASKCE----FLANLHITALLNVSRRT----------------------------------------------SEACATHLHYKWIPV
.| | ...... ... .|    .| .|.||....... .                                              .    ...|| ..|.
ritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpw

EDSHTADISSHFQEAIDFIDCVRE--KGGKVLVHCEAGISRSPTICMAYLM-----KTKQFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYESE
.| ...|..........|.. ...  ..|.||||| ||..|. |...||||     |.. . | ||.......|... ...... .| ... |
pdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
0051082 (Phosphotyrosine protein) phosphatases II 181-313 1e-26 88.8 In-house 10-149 (151) alignment 
Range on Protein: 181-313
Range on HMM: 10-149/151.0
EILPFLYLGSAYHASKCEFLANLHITALLNVSRRT------SEACATHLHYKWIPVEDSHTADISSHFQEAIDFIDCVREK-GGKVLVHCEAGISRSPTI
 . ..||.... .|   |.|..|.|.. .|.   .      .   .. .....||..| .. ... .|.....|.. ...| .|.||||| ||..|. |.
yvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtl

CMAYLMKtKQFRLKEAFDYIKQRRS-MVSPNFGFMGQLLQY
...|||.  .. | ||.......|  .| || .|. ||...
valylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal
subfamily_STYX_pd Subfamily STYX 181-315 6e-26 84.5 In-house 14-155 (166) alignment 
Range on Protein: 181-315
Range on HMM: 14-155/166.0
EILPFLYLG--SAYHASKCEFLANLHITALLNVsRRTSEAC------ATHLHYKWIPVEDSHTADISSHFQEAIDFIDCVREKGGKVLVHCEAGISRSPT
|||| |.||  ||   || | | .  || .. . |.. ||         ...|  . | |. . .|  .. .  .|||   .|||||||| .|||||| .
eilpglflgpysaamksklevlkkhgithivci.rqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaa

ICMAYLMKTKQFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYES
. .||.|.|  .. .||| |...||  ..|| ||. || .||.
lviayimetyglkyreafayvqerrfcinpnegfvsqlkeyea
0049772 (Phosphotyrosine protein) phosphatases II 183-316 4.6e-36 120.5 In-house 155-272 (314) alignment 
Range on Protein: 183-316
Range on HMM: 155-272/314.0
LpflylgSAYHASKCEFLAnlhitallnvsRRT---SEACATHLHYKWIPVEDsHTADISSHFQEAIDFIDCVrEKGGKVLVHCEAGISRSPT-ICMAYL
       . ..|.  |.|            ...   .    ....|..|||.| ..|.....|.|...||. . .|||.||||| ||..|..| ...|||
g......neptaadlellk...........eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaayl

MKTKQFRLKEAFDYIKQRRSmVSPNFGFMGQLLQYESE
||  .. |.||.......|. ..||.||. ||.||| .
mkllgvsleealedvrlkRp.inpnpgfieqleqyefi
subfamily_MKPLT_pd Subfamily MKPLT 185-318 8e-36 117.0 In-house 28-161 (164) alignment 
Range on Protein: 185-318
Range on HMM: 28-161/164.0
FLYLGSAYHASKCEFLANLHITALLNVSRRTSEACATHLHYKWIPVEDSHTADISSHFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMAYLMKTKQF
 |||| | || . . | .|.||  .|||. . .| .  . |  . |||  .  .||... | .|.    . ||.|||||  | ||| .. .|.|.| |..
tlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgw

RLKEAFDYIKQRRSMVSPNFGFMGQLLQYESEIL
 ||||..|.|.|||.|.|| ||. || ..|  ||
tlkeayeylkerrsivapnrGflkqlakfeelil
subfamily_MKPLV_pd Subfamily MKPLV 185-318 8e-36 117.0 In-house 28-161 (164) alignment 
Range on Protein: 185-318
Range on HMM: 28-161/164.0
FLYLGSAYHASKCEFLANLHITALLNVSRRTSEACATHLHYKWIPVEDSHTADISSHFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMAYLMKTKQF
 |||| | || . . | .|.||  .|||. . .| .  . |  . |||  .  .||... | .|.    . ||.|||||  | ||| .. .|.|.| |..
tlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgw

RLKEAFDYIKQRRSMVSPNFGFMGQLLQYESEIL
 ||||..|.|.|||.|.|| ||. || ..|  ||
tlkeayeylkerrsivapnrGflkqlakfeelil
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 185-317 3.3e-23 75.7 In-house 9-152 (154) alignment 
Range on Protein: 185-317
Range on HMM: 9-152/154.0
FLYLGSAYHASKCEFLANLHITALLNVSRRTSEACATH---------LHYKWIPVEDSHTADISSHFQEAIDFIDCVR--EKGGKVLVHCEAGISRSPTI
|||..|   |     | . .|. .|||.  .... . .         ..|  . . |    ||  ... | .|||      . .|||||...|.||| ..
flyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaal

CMAYLMKTKQFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYESEI
 ..|||. ..  | .|.  .|. | ...|| ||. || ..| | 
lisylmdklkislslalellkdsryiikPnqGflkqleifekel
DSPc Dual specificity phosphatase, catalytic domain 186-315 3.1e-48 158.0 Pfam-A 1-132 (133) alignment 
Range on Protein: 186-315
Range on HMM: 1-132/133.0
LYLGSAYHASkCEFLANLHITALLNVSRRTSE---ACATHLHYKWIPVEDSHTADISSHFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMAYLMKTK
|||||...|| ...|..|.||. .||......    . .. .| .|||||.....||....||..||. ...||.||||||.||||||.|...|||||||
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

QFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYES
...|.||....|.|||..|||.||..|||.||.
nlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 186-315 3.1e-48 158.0 In-house 1-132 (133) alignment 
Range on Protein: 186-315
Range on HMM: 1-132/133.0
LYLGSAYHASkCEFLANLHITALLNVSRRTSE---ACATHLHYKWIPVEDSHTADISSHFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMAYLMKTK
|||||...|| ...|..|.||. .||......    . .. .| .|||||.....||....||..||. ...||.||||||.||||||.|...|||||||
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

QFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYES
...|.||....|.|||..|||.||..|||.||.
nlslneAyefvkerrskispnagflrqLleyer
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 186-315 1.6e-25 82.9 In-house 6-139 (145) alignment 
Range on Protein: 186-315
Range on HMM: 6-139/145.0
LYLGSAYHASKCEFLANLHITALLNVSR----RTSEACATHLHYKWIPVEDSHTADISSHFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMAYLMKT
|| ||| ||..   | .| |. ..|..      ..|. . ...   |  || .. |.| ||.|  ||||  .|.|  |.||| ||.||| |. .|.||| 
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

KQFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYES
 .. | ||   .. .| .  ||  |. .||. | 
cnmtlseaarqvrsnrllaypnvtflknllnlek
0045450 (Phosphotyrosine protein) phosphatases II 192-317 1.8e-27 92.3 In-house 87-303 (307) alignment 
Range on Protein: 192-317
Range on HMM: 87-303/307.0
YHASKC--------------------------------EFLANLHITALLNVSRRT----------------------------SEACATHLHYKWIPVE
..||                                  ..| ....|....... .                            ||    .... ...|.
iNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevt

DS-----------------HTADISSHFQEAIDFIDCVRE------KGGKVLVHCEAGISRSPTICMAYLMKTKQ--------FRLKEAFDYIKQRRSMV
|.                    .....|.|..|||. ||.      |||.||||| ||..|..|...||||..          . | ||.......|. .
dldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpga

SPNFGFMGQLLQYESEI
 .|.... .| ... | 
vqnpeqyrflyeallel
subfamily_DSP23_pd Subfamily DSP23 196-298 4.5e-08 27.9 In-house 23-126 (148) alignment 
Range on Protein: 196-298
Range on HMM: 23-126/148.0
KCEFLANLHITALLNVS---RRTSEACAtHLHYKWIPVEDSHTAdISSHFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMAYLMKTKQFRLKEAFDY
. ..|..| .  |. ..   |  .||.   | .. . ..| |        .| .  ..   ||.  | |||  |  |. |.   ||.| ...   ||   
qyrylldlgvrylvslteegrphveatp.nltlvrlriddyhpp.aleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiae

IKQRRS
....| 
vrrlrp
subfamily_MSG5_pd Subfamily MSG5 204-315 1e-18 61.0 In-house 47-158 (165) alignment 
Range on Protein: 204-315
Range on HMM: 47-158/165.0
HITALLNVSRRTSEACATHLHYKWIPVEDSHTADISSHFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMAYLMKTKQFRLKEAFDYIKQRRSMVSPN
 .  ..||..  ..        |.  .|  |.. |   . .    | . . |. |.||||. |.||| .. .||.||  .. |..|.| .| .   .||.
sfdlvinvakeindlellvpavkyyhiewehdskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddisps

FGFMGQLLQYES
.|.. ||...| 
iglifqlmewev
0043336 (Phosphotyrosine protein) phosphatases II 205-315 7.2e-22 73.6 In-house 158-274 (278) alignment 
Range on Protein: 205-315
Range on HMM: 158-274/278.0
ITALLNVSRRTSEACATHLHYKWIPVEDSHTA-DISSHFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMAYLM-----KTKQFRLKEAFDYIKQRRS
..  |.|... .  . |..|| .... | ..  ..|....   ....... ..|.||||| ||..|. |....||.     |.. . | ||.......| 
tvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRp

MVSPNFGFMGQLLQYES
.  ... .. .| ... 
gavqtpsqyrflyeall
0039614 (Phosphotyrosine protein) phosphatases II 206-318 4.3e-27 90.8 In-house 171-289 (297) alignment 
Range on Protein: 206-318
Range on HMM: 171-289/297.0
TALLNVSRrtSEACATHLHYKWIPVEDSHTADISSHFQEAIDFIDCVRE---KGGKVLVHCEAGISRSPTICMAYLM-----KTKQFRLKEAFDYIKQRR
.  |.|..  ..   |. |. ...  | .. .......|...... ...   |||.||||| ||..|. |...||||     |.... ..||.......|
vrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqR

SMVSPNFGFMGQLLQYESEIL
... ...... .| ... | |
pgavqtpsqyrflydallell
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 206-280 5.5e-06 20.6 In-house 163-237 (288) alignment 
Range on Protein: 206-280
Range on HMM: 163-237/288.0
TALLNVSRRTSEACATHLHYKWIPveDSHTADISSHFQEAIDFIDCVREKG-GKVLVHCEAGISRSPTICMA-YLMK
.  | . ....|   |...|.  |  |    . .  . | .. ..   ..  |...||| ||. |..|   .  |..
lrklllekkkteleitqyqylaWp..dhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalid
0047943 (Phosphotyrosine protein) phosphatases II 207-312 1.5e-19 66.0 In-house 153-266 (273) alignment 
Range on Protein: 207-312
Range on HMM: 153-266/273.0
ALLNVSRRTSEACATHLHYKWIPVEDSHTADISSHFQEAIDFIDCVRE---KGGKVLVHCEAGISRSPTICMAYLM-----KTKQFRLKEAFDYIKQRRS
  | ...  .. . |  |. . .  | .. .  ... | |.... ..|   ..|.|.||| ||..|. |.....|.     |.... ..||. .....| 
rtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRp

MVSPNFGFMGQLLQ
.. ... .. .| .
gmvqtpeqyrflye
0046845 (Phosphotyrosine protein) phosphatases II 208-301 4.1e-15 51.4 In-house 152-257 (284) alignment 
Range on Protein: 208-301
Range on HMM: 152-257/284.0
LLNVSRRT-SEACATHLHYKWIPVEDSHTADISSHFQEAIDFIDCVREK---GGKVLVHCEAGISRSPTICMAYLMKTK--------QFRLKEAFDYIKQ
 | ...   ..   |. |. ...  | .. . .....| ..... ..|.   ||...||| ||..|. |.....|...          . . ||. ....
tleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlre

RRSMVS
.| .  
qRpgmv
DSPc_SM00195 209-299 5.2e-07 24.6 In-house 147-243 (263) alignment 
Range on Protein: 209-299
Range on HMM: 147-243/263.0
LNVSRRT--SEACATHLHYKWIPveDSHTADISSHFQEAIDFIDCVRE-KGGKVLVHCEAGISRSPTICMAYL-----MKTKQFRLKEAFDYIKQRRSM
|...  .   .  .|...||  |  |. . |  ... | . ...  .. . | ..||| ||..|. |.... .      ..|.. ..| .  ... | .
leltkegkeetrkvtqyqyknWp..dhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpg
PTPc_SM00194 209-299 5.2e-07 24.6 In-house 147-243 (263) alignment 
Range on Protein: 209-299
Range on HMM: 147-243/263.0
LNVSRRT--SEACATHLHYKWIPveDSHTADISSHFQEAIDFIDCVRE-KGGKVLVHCEAGISRSPTICMAYL-----MKTKQFRLKEAFDYIKQRRSM
|...  .   .  .|...||  |  |. . |  ... | . ...  .. . | ..||| ||..|. |.... .      ..|.. ..| .  ... | .
leltkegkeetrkvtqyqyknWp..dhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpg
Y_phosphatase Protein-tyrosine phosphatase 210-301 3.1e-08 28.7 Pfam-A 122-214 (235) alignment 
Range on Protein: 210-301
Range on HMM: 122-214/235.0
NVSRRTSEA---CATHLHYKWIPveDSHtadISSHFQEAIDFIDCVREKG----GKVLVHCEAGISRSPTICMAYLMKTKqFRLKEAFDYIKQRRSMVS
... ...|      ..|||.  |  |.    . .. .. .|.|. |...     |.|.||| ||..|. |.... ..  . .. .| .|  .  ... .
elkkkkeesekrevkqlhytnWp..dhg...vpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq.leaeeevdvlqivkelRk
Y_phosphatase Protein-tyrosine phosphatase 210-301 3.1e-08 28.7 In-house 122-214 (235) alignment 
Range on Protein: 210-301
Range on HMM: 122-214/235.0
NVSRRTSEA---CATHLHYKWIPveDSHtadISSHFQEAIDFIDCVREKG----GKVLVHCEAGISRSPTICMAYLMKTKqFRLKEAFDYIKQRRSMVS
... ...|      ..|||.  |  |.    . .. .. .|.|. |...     |.|.||| ||..|. |.... ..  . .. .| .|  .  ... .
elkkkkeesekrevkqlhytnWp..dhg...vpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq.leaeeevdvlqivkelRk
0040438 (Phosphotyrosine protein) phosphatases II 211-318 6.7e-25 83.4 In-house 117-276 (317) alignment 
Range on Protein: 211-318
Range on HMM: 117-276/317.0
VSRR---------------------------TSEACATHLHYKWIPVEDS----------------HTADISSHFQEAIDFIDCVREK----GGKVLVHC
. .                            .||    . .. ...|||.                   .. ..... .||.. |||.    ||.|||||
LteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHC

EAGISRSPTICMAYLM-----KTKQFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYESEIL
 ||..|. |...||||     |.... ..||.......|... ...... .| ... |.|
saGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
0051299 (Phosphotyrosine protein) phosphatases II 215-304 1.5e-15 52.8 In-house 177-272 (288) alignment 
Range on Protein: 215-304
Range on HMM: 177-272/288.0
TSEACA--THLHYKWIPveDSHTADissHFQEAIDFIDCVREK----GGKVLVHCEAGISRSPTICMAYLM-----KTKQFRLKEAFDYIKQRRSMVSPN
 .. .   ||.||. .|  | .. |   .... .||.  ||..    || |.||| ||..|. |.....|.     |.. . . ||. .....| .. ..
gdgesrtvthfhytnwp..dhgvpd...spellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqt

F
.
p
0036941 (Phosphotyrosine protein) phosphatases II 217-318 1.5e-24 82.3 In-house 167-277 (297) alignment 
Range on Protein: 217-318
Range on HMM: 167-277/297.0
EACATHLHYKWIPvedshTADISSHFQEAIDFIDCVRE------KGGKVLVHCEAGISRSPTICMAYLM--------KTKQFRLKEAFDYIKQRRSMVSP
.   ||.||. .|       .. ..... .|||. ||.      .||.||||| ||..|| |...|.||        |.... ..||. .....| .. .
srtvthfhytgwp.....dhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavq

NFGFMGQLLQYESEIL
..... .| ... | |
tleqyrflyeallell
0038934 (Phosphotyrosine protein) phosphatases II 217-329 2.2e-22 75.1 In-house 74-188 (194) alignment 
Range on Protein: 217-329
Range on HMM: 74-188/194.0
EACATHLHYKWIPVEDSHTADISSHFQEAIDFIDCVREK--GGKVLVHCEAGISRSPTICMAYLMKTKQFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYE
|  .  ..|  .|..| .|.   .  .. .|..|.. ..  ||.|.||| ||..|..|.. |||... .. ..|| ......|  . || ... .||.. 
efekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkry

SEILPSTPNPQPPSC
.|. ..   |. |. 
kelrkavlapekpel
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 217-281 6.5e-07 23.6 In-house 173-234 (307) alignment 
Range on Protein: 217-281
Range on HMM: 173-234/307.0
EACATHLHYKWIPVEDSHTADISshfQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMAYLMKT
. . |  |..|    |  . .|      ||.... || .   |.||| ||. || ||    |.. 
qksrtiqhlqwenwpdrgvpqin...ltainlleavrydtnpvvvhcsaGvGrsGtivaislvqd
DUF442 Putative phosphatase (DUF442) 217-267 2.1e-06 16.0 Pfam-A 52-97 (110) alignment 
Range on Protein: 217-267
Range on HMM: 52-97/110.0
EACATHLHYKWIPVE-DSHTADISSHFQEAIDfidcvrEKGGKVLVHCEAGI
 | |  |.|...||   . |.|   .||.|..      | .| ||..| .| 
aaeaaglaylfvPvisgeiteddveafqrala......eaegpvlayCrsGt
0050432 (Phosphotyrosine protein) phosphatases II 219-304 1.8e-15 52.5 In-house 198-285 (308) alignment 
Range on Protein: 219-304
Range on HMM: 198-285/308.0
CATHLHYKWIPveDSHTADISSHFQEAIDFIDCVReKGGKVLVHCEAGISRSPTICMAYLM-----KTKQFRLKEAFDYIKQRRSMVSPNF
  ||.||.  |  | .. .  ... . ..... .. .||...||| ||..|. |.....|.     |.. . . ||. .....| .. ...
tvthfhytnWp..dhgvPpspeilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp
PTPc_DSPc_SM00012 222-295 8.6e-10 34.1 In-house 2-81 (105) alignment 
Range on Protein: 222-295
Range on HMM: 2-81/105.0
HLHYKWIPVEDSHTADISSHFQEAIDFIDCVREK---GGKVLVHCEAGISRSPTICMAYLMKTKQFRLK---EAFDYIKQ
. ||..    | .. . |... |... .. ...|   .. |.||| ||..|. |.......  .  . .   . |...|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivke
subfamily_Laforin_pd Subfamily Laforin 223-299 4.3e-10 32.8 In-house 77-153 (183) alignment 
Range on Protein: 223-299
Range on HMM: 77-153/183.0
LHYKWIPVEDSHTADISSHFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMAYLMKTKQFRLKEAFDYIKQRRSM
| | |.|.||  |      . .|. .. .. ||| .| |||.||. || .|   .|.   .. |.    ..  .| .
layiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpv
subfamily_PTPMT1_pd Subfamily PTPMT1 226-316 2e-17 58.2 In-house 77-167 (171) alignment 
Range on Protein: 226-316
Range on HMM: 77-167/171.0
KWIPVEDSHTADISSHFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMAYLMKTKQFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYESE
  ... |   |    . .....||. |..|| .| |||.|| .|| |.  .||||.... ..|| ...|..|...  .   . .| .||..
lqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeek
subfamily_PTEN_pd Subfamily PTEN 227-299 8.2e-07 24.2 In-house 84-158 (184) alignment 
Range on Protein: 227-299
Range on HMM: 84-158/184.0
WIPVEDSHTADISsHFQEAIDFIDC-VREK-GGKVLVHCEAGISRSPTICMAYLMKTKQFRLK-EAFDYIKQRRSM
 .|..| ... ..  ..|... |.  . |.    | |||.||  |. .. .|||.|..... . || .. .. |. 
vypfdDhnppple.lleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtk
subfamily_DSP11_pd Subfamily DSP11 232-298 8e-06 19.9 In-house 91-158 (178) alignment 
Range on Protein: 232-298
Range on HMM: 91-158/178.0
DSHTADISSHFQEAI-DFIDCVREKGGKVLVHCEAGISRSPTICMAYLMKTKQFRLKEAFDYIKQRRS
.  . .. ..|.||. .|..   ...  . |||  |. |.  .   ||....... ..| .  .. | 
evpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearG
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 239-300 1e-06 23.1 In-house 174-241 (290) alignment 
Range on Protein: 239-300
Range on HMM: 174-241/290.0
SSHFQEAIDFIDCVREKGGKVLVHCEAGISRS---PTICMAYLM---KTKQFRLKEAFDYIKQRRSMV
  . . ... |. |. ..  |.|||  |||||   ..| ..| .   ..... |... ......| ..
qedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqrala
subfamily_RNGTT_pd Subfamily RNGTT 239-299 5.4e-06 20.2 In-house 97-156 (189) alignment 
Range on Protein: 239-299
Range on HMM: 97-156/189.0
SSHFQEAIDF-IDcvREKGGKVLVHCEAGISRSPTICMAYLMKTKQFRLKEAFDYIKQRRSM
 ..|.. ..  ..  ..    . |||  |  |.  . ..||...... ...| .  .. |  
vkefiklveeffk..knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRpp
0048567 (Phosphotyrosine protein) phosphatases II 242-300 2.3e-09 31.8 In-house 60-123 (157) alignment 
Range on Protein: 242-300
Range on HMM: 60-123/157.0
FQEAIDFIDCVREKGGKVLVHCEAGI---SRSPTICMAYLMKTKQFRLKEAFDYIKQRR--SMV
.. . .|.......|... ||| ||    .|. |.. .||..  .|   ||...... |  |..
ilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvp
subfamily_PTPDC1_pd Subfamily PTPDC1 246-298 1.4e-06 22.9 In-house 105-156 (182) alignment 
Range on Protein: 246-298
Range on HMM: 105-156/182.0
IDFIDCVREKGgKVLVHCEAGISRSPTICMAYLMKTKQFRLKEAFDYIKQRRS
.  .. . ..| || ||| ||  |   .  .||. .|..  ..| . ....|.
vkvvafalqeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrp
subfamily_CDC14_pd Subfamily CDC14 247-297 2.2e-08 28.3 In-house 254-304 (328) alignment 
Range on Protein: 247-297
Range on HMM: 254-304/328.0
DFIDCVREKGGKVLVHCEAGISRSPTICMAYLMKTKQFRLKEAFDYIKQRR
 |.. . .  |.. ||| ||. |  |.  .||||. .|  .||  ...  |
kfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricr
subfamily_Dicty-DSP-Subfam1_pd Subfamily Dicty-DSP-Subfam1 257-303 6.8e-06 18.8 In-house 67-116 (128) alignment 
Range on Protein: 257-303
Range on HMM: 67-116/128.0
GKVLVHCEAGISRSPTICMAYLMKTKQFRLKEAFDY---IKQRRSMVSPN
  . |||| |  |.  .  .| || | . ||.|...   |  |. ..| .
lvlyvhcecgcdrtgevlasyvmkykgydlkkalewdyaiagrdinisnr
subfamily_Dicty-DSP19-1_pd Subfamily Dicty-DSP19-1 257-303 6.9e-06 18.8 In-house 66-115 (128) alignment 
Range on Protein: 257-303
Range on HMM: 66-115/128.0
GKVLVHCEAGISRSPTICMAYLMKTKQFRLKEAFDY---IKQRRSMVSPN
  . |||| |  |.  .  .| || | . ||.|...   |  |. ..| .
lvlyvhcecgcdrtgevlasyvmkykgydlkkalewdyaiagrdinisnr