Gene PTPDC1 in Homo sapiens

Synonym: PTP9Q22, RP11-490F3.2, PTPDC1

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily PTPDC1
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP038_AA protein Get Run
HsapP038_AA_134-299 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0038934 (Phosphotyrosine protein) phosphatases II 122-298 2.2e-37 123.9 In-house 3-176 (194) alignment 
Range on Protein: 122-298
Range on HMM: 3-176/194.0
PARWSEQEQAikgvySSWVTDNILAMARPSSELLEKYhiIDQFLSHGIKTIINLQRPGEHASCGNPLEQESGFTYLPEAFMEAGIYFYNFGWKDYGV---
| ||   |.      ....|....|...|.|. |.||  |.... ......... .   .  .      .....| || |..|||..... ..|.|.   
Pdrwlkyerv.....gdiitgrfiafkvPlsgsldky..ieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPs

-ASLTTILDMVKVMTFALQEGKVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKRPNSIQTRGQLLCVREFTQFL
 . |...||.|.... . ..|.||.||.|||||||.|.|.||.   .|.|..|| ..| |||..|.....|  .... ..|
leillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykel
0044763 (Phosphotyrosine protein) phosphatases II 123-303 1.4e-34 114.7 In-house 9-175 (178) alignment 
Range on Protein: 123-303
Range on HMM: 9-175/178.0
ARWSEQEQAIKGVYSSWVTDNILAMARPSsellekYHIIDQFLSHGIKTIINLQRPGEHASCGnpleqesgftYLPEAFMEAGIYFYNFGWKDYGVAS-L
  . |..... . . |.......... |.       . ....  .||..|.||  . |.  ..          ..|....|||| ...... |.|| . |
lsnleglersdyinaseilpglylgslpp......addlellkelgithivnlteelelgflk..........cdpywpeeagiqylhipipDhgvpdll

TTILDMVKVMTFA--LQEGKVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKRPnSIQTRGQLLCVREFTQFLTPLRN
  .|..|. .  |   ..|.|..||.||.||.|.|.|.||.   ......|| .||..||  ....|||  ..|| ..| . ..
ehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllkesd
subfamily_PTPDC1_pd Subfamily PTPDC1 124-305 3.9e-93 305.0 In-house 2-182 (182) alignment 
Range on Protein: 124-305
Range on HMM: 2-182/182.0
RWSEQEQAIKGVYSSWVTDNILAMARPSSELLEKYHIIDQFLSHGIKTIINLQRPGEHASCGNPLEqESGFTYLPEAFMEAGIYFYNFGWKDYGVASLTT
||||.||||||.||.|||..|||.||||.| ...|...|.| ..|||..||||..|||||||..|| ||||.| .||.||.|||.|||||||||||||..
rwseeeqaikGlystWvtedilalarpsqeaideyklldkfkesgikavinLqekgehasCGagle.esGfsYdlealmeqgiyvynfgwkDygvasler

ILDMVKVMTFALQEGKVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKRPNSIQTRGQLLCVREFTQFLTPLRNIF
|||.|||..|||||||||.||||||||||||||||||.|.|.||..|| .||.|||.|||||.|. .|.||..||.|||...
iLdivkvvafalqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvkefalfliplrkvy
0041856 (Phosphotyrosine protein) phosphatases II 124-300 3.7e-34 113.3 In-house 6-172 (182) alignment 
Range on Protein: 124-300
Range on HMM: 6-172/182.0
RWSEQEQAIKGVYSSWVTDNILAMARPSSELLEK--------YHIIDQFLSHGIKTIINLQrpgehascgnpleqesGFTYLPEAFMEAGIYFYNFGWKD
|.|.      . .......|......|... .          .. .... ..||.||.||                 .. | || .. .|| .....| |
rysdilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt................eelywpellerlgiqylylpwpD

YGVASLTTILDMVKVMTFalQEGKVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKRPNSIQTRGQLLCVREFTQFLTP
.|| .| ..||... .    ..|.|..||.||.||||.|.|.||.   ......|. .|| .||....|  |.  .. .  .|  
hgvpdldelldfieevle..eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallelll
0045450 (Phosphotyrosine protein) phosphatases II 124-297 4e-28 94.5 In-house 25-302 (307) alignment 
Range on Protein: 124-297
Range on HMM: 25-302/307.0
RWSEQEQAIKGVYSSW----------------------------------------------------------------VTDNILAMARPSSELLEKYh
 ..  ..... ..| .                                                                ......|.  | .| .|.. 
fltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedF.

iIDQFLSHGIKTIINLQRPGEHAS----CGNPLE-----------------QESGFTYLP-------EAFMEAGIYFYNF-GWKDYGVA-SLTTILDMVK
 . ..  .|...|..| .. |...       |.|                 ...|.|..        . ...  .. . . || |.||  |. ..||...
.wrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfie

VMTFAL----QEGKVAIHCHAGLGRTGVLIACYLVFATR--------MTADQAIIFVRAKRPNSIQTRGQLLCVREFTQF
 .  ||    ..|.|..||.||.||||..||.||.   .        .....|. ..|..||...|. .|.  ..|. ..
evrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
subfamily_CDC14_pd Subfamily CDC14 125-292 2.4e-22 74.2 In-house 161-318 (328) alignment 
Range on Protein: 125-292
Range on HMM: 161-318/328.0
WSEQEQAIKGVYSSWVTDNILAMARPSS--ELLEKY------HIIDQFLSHGIKTIINLQRPgehascgnpleqesgfTYLPEAFMEAGIYFYNFGWKDY
. . |..  | ..  | | .||.| | .  .| ..|      .... | .....|.. | .                  |  . | .||.  ..  . | 
YekyervenGDfnwivPdkflalagPhnkskledgyplhaPeklleyfrknnvttvvrLnkk................lYdakkftdaGfdhkDlffiDG

GVASLTTILDMVKVMTFAlqEGKVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKRPNSIQTRGQLLCVR
.. | . .  .....  |  ||..|.||.||||||| ||||||.   |.|| .|| ..|  || |. .  |  ...
stPsdaivkkfleiaeka..eGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGsvigpqqkflee
PTEN_1 132-298 3.7e-36 119.8 In-house 21-192 (196) alignment 
Range on Protein: 132-298
Range on HMM: 21-192/196.0
IKGVYSSWVTDNILAMARPSSElLEKYHIIDQFLSHGIKTIINLQRPGEHASCGNPLEQE-SGFTYLPEAFMEAGIYFYNFGWKDYGVASLTTILDMVKV
  .. .|.....  |..||        . . ..|..  .   ||. .| .. .   .| | ||..| .| |.. |. ...|...|.|. ||  ..|..|.
dltyitsriiamgkapsrpllq.eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicks

MTFALQ----EGKVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKR-PNSIQTRGQLLCVREFTQFL
.  .|.    ...|..||.|||||.|...|.||... ..|||.|. .||.|| |...... |  ....| ..|
fiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaell
0046846 (Phosphotyrosine protein) phosphatases II 133-298 2.7e-38 126.8 In-house 8-172 (176) alignment 
Range on Protein: 133-298
Range on HMM: 8-172/176.0
KGVYSSWVTDNILAMARPSSELLE----KYHIIDQFLSHGIKTIINLQRPGEHASCGNPleqesgftYLPEAFMEAGIYFYNFGWKDYGVASLTTILDMV
 . .......|.....||           .. .......||....||. . |..... |        .... ....|| .....| |.|| .|. .|...
ldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcp........nywpeleklgiqylhlpwpDhgvpdlelllell

KVMTFALQEG-KVAIHCHAGLGRTGVLIACYLVFA-TRMTADQAIIFVRAKRP-NSIQTRGQLLCVREFTQFL
. .  ||.|| .|..||.||.||||.|.|.||.     .....|. .||..|| ...||..|.  ..|| ..|
efirealkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll
0043147 (Phosphotyrosine protein) phosphatases II 135-300 2.3e-35 117.2 In-house 13-162 (172) alignment 
Range on Protein: 135-300
Range on HMM: 13-162/172.0
VYSSWVTDNILAMARPSSELLEKYhiIDQFLSHGIKTIINLQRPgehascgnpleqesgfTYLPEAFMEAGIYFYNFGWKDYGVASLTTILDMVKVMTF-
.. ....|...|.  | .. |...  .... ..||..|.|| .                 .|.|| ... || .. ..| |.|| .|  .|.... .   
ldlyyipdrfiatqgplrntladf..wrmlkelgithivnltel................lydpellerlgiqylylpwpDhgvpllellleflefidel

--ALQEGKVAIHCHAGLGRTGVLIACYLVFaTRMTADQAIIFVRAKRPNSIQTRGQLLCVREFTQFLTP
    ..|.|..||.||.||||.|.|.||.   ......|. .||.|||...|. .|. ....| ..|  
lalspggpvlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekllll
0039614 (Phosphotyrosine protein) phosphatases II 136-296 7.1e-30 99.9 In-house 84-286 (297) alignment 
Range on Protein: 136-296
Range on HMM: 84-286/297.0
YSSWV-----------TDNILAMARPSSELLEKYhiIDQFLSHGIKTIINLQRPGEHAS-CGNPLEQESGfT------YLPEAFMEAGIYFYNF------
 |...           |....|.  |..| .|..  .  .  .|...|..| .. |.   |     .|.| |      .| . ....|.. ...      
dsdYinAsyvdgydlltrkfIatqgPlpetvedF..wrmvweqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtnng

-----------GWKDYGVA-SLTTILDMVKVMTFAL----QEGKVAIHCHAGLGRTGVLIACYLV-----FATRMTADQAIIFVRAKRPNSIQTRGQLLC
           || |.||  ||...|.... .  ||    ..|.|..||.||.||||..||.||.        ......|. ..| .||...|| .|.  
esrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrf

VREFTQ
.... .
lydall
0040439 (Phosphotyrosine protein) phosphatases II 137-297 1e-28 96.1 In-house 49-244 (249) alignment 
Range on Protein: 137-297
Range on HMM: 49-244/249.0
SSWVTDNILAMARPSSELLEKYhiIDQFLSHGIKTIINLQRPGEH--ASCGNPLEQeSGFT----------------------------YLPEAFMEAGI
 ........|.  | .| .|..  ....  .||..|..| .. |.    |     . .|..                            | .| ..  .|
gyyikrrfiatqgPlpetvedf..wrmlwelgitvivmLtslvelgrekcaqywpl.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhi

YFYNFGwkDYGVA-SLTTILDMVKVMTFAL----QEGKVAIHCHAGLGRTGVLIACYLV-----FATRMTADQAIIFVRAKRPNSIQTRGQLLCVREFTQ
.....   |.||  |. ..||... .  ||    ..|.|..||.||.||||..||.||.        ......|. ..| .||...|. .|.  . |. .
qytdwp..dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeall

F
.
e
0036282 (Phosphotyrosine protein) phosphatases II 138-297 2e-32 107.6 In-house 13-168 (174) alignment 
Range on Protein: 138-297
Range on HMM: 13-168/174.0
SWVTDNILAMARPSSellekyhIIDQFLSHGIKTIINLQRPGEHASCG--NPLEQesgftyLPEAFMEAGIYFYNFGWKDYGVASLTTILDMVKVMTFAL
|..|....|.. | .        .... ..||.|...| .. |  ...  |          |.| . . || .. ..| |.|| .|...|..|| .  ||
syitprliagqgpla.......fwemlkelgittvvmlleekelglykcinywpe......lredlerlgiqylylpwpDhgvpdlsillefvkfveeal

QE---GKVAIHCHAGLGRTGVLIACYLVFATRM-TADQAIIFVRAKR---PNSIQTRGQLLCVREFTQF
.|   |.|..||.||.||||.|.|.||.    . ....|. .||..|   |...|| .|.  ...| ..
sedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekl
0042113 (Phosphotyrosine protein) phosphatases II 138-296 1.1e-29 98.9 In-house 43-240 (245) alignment 
Range on Protein: 138-296
Range on HMM: 43-240/245.0
SWV-----TDNILAMARPSSEllEKYHIIDQFLSHGIKTIINLQRPGEHASCG------------------NPLEQESGFTYL---------PEAFMEAG
|.|     |....|.. |..|     . . .. ..||.||..| .. |.  ..                  . |. |.  .|          .. .   .
syvdgyritpkfiatqgPlpe..tvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrev

IYFYNFGWKDYGVAS-LTTILDMVKVMTFALQ---EGKVAIHCHAGLGRTGVLIACYLV-----FATRMTADQAIIFVRAKRPNSIQTRGQLLCVREFTQ
| .. ..| |.||.. | ..||... .  ||.   .|.|..||.||.||||..||.||.        ......|. ..| .||...|| .|.  ..|. .
ihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall
0037934 (Phosphotyrosine protein) phosphatases II 138-297 7.7e-29 96.4 In-house 40-240 (243) alignment 
Range on Protein: 138-297
Range on HMM: 40-240/243.0
SWVTDNILAMARPSSELLEK--YHIIDQFLSHGIKTIINLQRPGEHASCGNPLEQESGFTY-------------------------LP-EAFMEAGIYFY
..||... |.  | .| .|   .. .. . ..||..|..| .. |.  .. .    ...||                         |. . .   .| ..
iyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyh

NFGWKDYGVAS-LTTILDMVKVMT----------FALQEGKVAIHCHAGLGRTGVLIACYLVFAT-RMTADQAIIFVRAKRPN-SIQTRGQLLCVREFTQ
 ..| |.|| .  . .||... ..           . ..|.|..||.||.||||.|||.||.    ......|. ..|..||. ..||..|.  ..|. .
ylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeall

F
.
e
0043336 (Phosphotyrosine protein) phosphatases II 138-297 7.7e-28 93.2 In-house 84-275 (278) alignment 
Range on Protein: 138-297
Range on HMM: 84-275/278.0
SWVTDNILAMARPSSELLEKYhiIDQFLSHGIKTIINLQRPGEhascgnpLEQESGFTYLPEAFMEAG--------------------------------
 .|.....|.  |..| .|..  .  .  .|..||..| .. |       |...  . | |. ... |                                
ynvprkfiatqgPlpetvedF..wrmvwelgvttivmLtelve.......lgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrt

-IYFYNFGWKDYGVA-SLTTILDMVKVMTFAL--QEGKVAIHCHAGLGRTGVLIACYLV-----FATRMTADQAIIFVRAKRPNSIQTRGQLLCVREFTQ
   .. .|| |.||  ||...||..|..  ||  ..|.|..||.||.||||..||.||.        ......|. ..| .||...||  |.  ..|. .
vthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall

F
.
e
0051082 (Phosphotyrosine protein) phosphatases II 138-290 6.5e-26 86.1 In-house 9-144 (151) alignment 
Range on Protein: 138-290
Range on HMM: 9-144/151.0
SWVTDNILAMARPSSellekyHIIDQFLSHGIKTIINLQRPGEHAscgnpleqesgftYLPEAFMEAGIYFYNFGWKDYGVASLTTI----LDMVKVMTF
|.||....... |..      . .... ..|||||.||  . |..             |.|| . |.|| .... . |  . .| ..    |......  
syvtgglyrsggpla......dflellkelgiktivnlrseeerg.............ycpeylpelgievlhipildwpdpglplsfdavleflellld

aLQEGKVAIHCHAGLGRTGVLIACYLVFaTRMTADQAIIFVRAKRPNSIQTRGQLLC
  ..|.|..||.||.||||.|.|.||.   ......|. ..|.|||...|.  | |.
.kkngpvlvHCsaGkgRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflf
subfamily_PTEN_pd Subfamily PTEN 138-281 9.3e-11 37.0 In-house 23-162 (184) alignment 
Range on Protein: 138-281
Range on HMM: 23-162/184.0
SWVTDNILAMARPSSELLEKYH----IIDQFLSHGIK---TIINLQRPGehascgnpleqesgfTYLPEAFmEAGIYFYnfGWKDYGVASLTTILDMVKV
|..|.||.||. |. .| . |      . .|| .  |    |.||.                  .|  . | .  .  |  . .|   ..|  . ..|. 
syiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrser...............kydskkf.dgrvavy..pfdDhnppplelleeived

MTFALQEGK---VAIHCHAGLGRTGVLIACYLVFATRMTAD-QAIIFVRAKRP---NS
..  |.| |   |..||.|| |||||||..||. .. ..   .|. .  ..|    ..
iekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkg
0040438 (Phosphotyrosine protein) phosphatases II 139-299 1.4e-25 85.6 In-house 83-276 (317) alignment 
Range on Protein: 139-299
Range on HMM: 83-276/317.0
WVTDNILAMARPSSEllEKYHIIDQFLSHGIKTIINLQRPGEHA---------ScGNPLEQESGFTYLPEAFMEAGIYFYNFGW----------------
. .....|.  | ..    .. .  .  .|...|..| .. |           . |..|. .  .  | . . .|||  ...                  
nlkrkfIatqgPlpn..tvedFwrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhy

---KDYGVA-SLTTILDMVKVMTFALQ--EGKVAIHCHAGLGRTGVLIACYLV-----FATRMTADQAIIFVRAKRPNSIQTRGQLLCVREFTQFLT
    |.||  |....||... .  ||.  .|.|..||.||.||||..||.||.        ......|. ..|..||...|| .|.  . .. ... 
tgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
subfamily_Laforin_pd Subfamily Laforin 157-285 6.3e-07 22.4 In-house 27-159 (183) alignment 
Range on Protein: 157-285
Range on HMM: 27-159/183.0
KYHIIDqFLSHGIKTIINLQRPG---EHASCGNPLEQESgFTYLPEAFMEAGIYFYNFGWKDYGVASLTTILDM-VKVMTFALQEG-KVAIHCHAGLGRT
. |.|| . |.|| ..|.||      ...|  .  ...     |   . | |. .  .  .|    |    |   | ..   |..| .| .|| ||.||.
vehvid.lksegitavislqtesdivknssgiyrynenl.pitlkklykeeglayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrs

GVLIACYLVFATRMTADQAIIFVRAKRPNSI-QTR
  ..  .| .    .  .   |. ||||    . .
taivcgflqyvlgwslakvqyfllakrpvvyidee
0045098 (Phosphotyrosine protein) phosphatases II 159-297 3.8e-28 94.1 In-house 79-270 (278) alignment 
Range on Protein: 159-297
Range on HMM: 79-270/278.0
HIIDQFLSHGIKTIINLQRPGEHA--SCGNPLEQeSG-----------------------------FTYLPEAFMEAGIYFYNF-GWKDYGVASLT---T
. .... ..||..|..| .  | .   |  .    .|                             .|. .| ....|.. ... .| |.|| ||.    
dfwrmlwelgitvivmltelvelgrekcaqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilks

ILDMVKVMTFAL---------------QEGKVAIHCHAGLGRTGVLIACYLVFAT---RMTADQAIIFVRAKRPN-SIQTRGQLLCVREFTQF
.|.... .  ||               ..|.|..||.||.||||.|.|.||.      ......|. ..| .||. ..|. .|.  . || . 
flellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyeflle
0048076 (Phosphotyrosine protein) phosphatases II 161-298 4.8e-30 99.5 In-house 22-142 (145) alignment 
Range on Protein: 161-298
Range on HMM: 22-142/145.0
IDQFLSHGIKTIINLqrpgehascgnpleqesgfTYLPEAFMEAGIYFYNFGWKDYGVASL-TTILDMVKVMTFALQEG-KVAIHCHAGLGRTGVLIACY
.... ..||.|..||                   |. .| . . || .....| |.|| .|  ..|.... .  ||.|| .|..||.||.||||.|.|.|
lellkdlgittvlnl...................tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaay

LVFATRMTADQAIIFVRAKRPNSIQTRGQLLCVREFTQFL
|..  ......|. .||..||..... |||  ..|| . |
lmlllgvsleealelvrsqrpgavpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 161-296 8.4e-29 95.5 In-house 22-142 (144) alignment 
Range on Protein: 161-296
Range on HMM: 22-142/144.0
IDQFLSHGIKTIINLQRPGEHASCGNPleqesgftylpeafmeaGIYFYNFGWKDYGVASL-TTILDMVKVMTFALQ-EGKVAIHCHAGLGRTGVLIACY
.... ..||.|.|||. . |.......                 || .....| |.|| .| . .|.... .  ||. .|.|..||.||.||||.|.|.|
lellkklgittvinlteeyepeflere.................giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaay

LVFATRMTADQAIIFVRAKRPNSIQTRGQLLCVREFTQ
|..  ......|. .||..||......|||  ..|. .
lmkklglsleealalvrsrrpgavpnpgqlrfLleyek
0049260 (Phosphotyrosine protein) phosphatases II 161-298 1.9e-28 94.5 In-house 26-149 (152) alignment 
Range on Protein: 161-298
Range on HMM: 26-149/152.0
IDQFLSHGIKTIINLQRPGEHASCGNPLEQesgftylpeafmeagiYFYNFGWKDYGVASLTTILDMVKVMT---FALQEGKVAIHCHAGLGRTGVLIAC
.... ..||.||..| .. | . .. .                    .... | |.|| .|. .|...  .       ..|.|..||.||.||||.|.|.
wrmlkelgittivmltellelgklkceqyi................qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaa

YLVFaTRMTADQAIIFVRAKRPNSIQTRGQLLCVREFTQFL
||.   ......|. .||.|||..... |||  . || ..|
ylml.lgvsleeavalvrekRpgavpnpgqlrflyefekll
0051429 (Phosphotyrosine protein) phosphatases II 161-298 1.1e-23 79.7 In-house 38-224 (272) alignment 
Range on Protein: 161-298
Range on HMM: 38-224/272.0
IDQFLSHGIKTIINLQRPGEHASCGNPLEQeSGFTYLPEAFMEA-----------------------------------------GIYFYNFGWKDYGVA
.... ..|||||..| .. |..... ...   |..||   ...                                             ..  .| |.||.
fwrlkelgiktivdLrseeErgrlkcdryw.pgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvp

S--LTTILDMVKVmtfalqEGKVAIHCHAGLGRTGVLIACYLVFaTRMT--------------ADQAIIFVRAKRPNSIQTRGQLLCVREFTQFL
.  | ..|...        .|.| .||.|| .|||...|..|.   ...              ...|.  .||.||...|| .|.|...|. . |
qeallellellld......ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallel
PTPc_motif_SM00404 162-285 6e-13 43.9 In-house 21-127 (140) alignment 
Range on Protein: 162-285
Range on HMM: 21-127/140.0
DQFLSHGIKTIINLQRPGEHAscgnplEQESGFTYLPEAfMEAgiyfynfGWKDYGVASLTTILDMVKVMtfALQEGKVAIHCHAGLGRTGVLIACYLVF
..  ..||...||...  .        ...|||..|    ..          ||  .. |  .||... .  . ..||| .|| ||. |.. ||..||  
allkklgithvinvteevslt......kensgfqilqip.ldd.......nekdklskyldkvldfiena..ekkggkvlVHCqaGvSRSatliiaYlmr

ATRMTADQAIIFVRAKRpNSIQTR
   .....|. ||. .| ..|. .
yrqlslaeayefvkerR.piispn
0050432 (Phosphotyrosine protein) phosphatases II 164-292 1.1e-20 69.7 In-house 128-292 (308) alignment 
Range on Protein: 164-292
Range on HMM: 128-292/308.0
FLSHGIKTIINLQRPGEhascgnpLEQESGFTYLPE----AFMEAGIYF---------------------------------YNFGWKDYGVAS-LTTIL
.  .....|. | .. |        ..|  . | |.     ..| | ..                                 .  .|.|.|| . .. .|
vweqnvrvIvmLtklve.......ngrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeill

DMVKVMTFALQEGKVAIHCHAGLGRTGVLIACYLV-----FATRMTADQAIIFVRAKRPNSIQTRGQLLCVR
|... .   |..|....||.||.||||..||..|.        .... .|. ..| .||...||  |.| . 
dflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylfly
0047943 (Phosphotyrosine protein) phosphatases II 165-292 5.7e-21 70.6 In-house 98-265 (273) alignment 
Range on Protein: 165-292
Range on HMM: 98-265/273.0
LSHGIKTIINLQRPGEhascgnpLEQESGFTYLPEA----FMEAG---------------------------------IYFYNFGWKDYGVA-SLTTILD
  .....|. | .. |       |..|  . | |.     ... |                                 ..|. .|| |.||  ||. .|.
weqnvrviVmLtelve.......lgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppsleslle

MVKVMTFALQ----EGKVAIHCHAGLGRTGVLIACYLV-----FATRMTADQAIIFVRAKRPNSIQTRGQLLCVR
.....  ||.    .|.|..||.||.||||..||..|.        ......|. ..| .||...||  |.. . 
fielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfly
0036941 (Phosphotyrosine protein) phosphatases II 166-302 5.2e-21 70.7 In-house 100-280 (297) alignment 
Range on Protein: 166-302
Range on HMM: 100-280/297.0
SHGIKTIINLQRPGEhascgnpLEQESGFTYLPEA---FM----------------EAGIY-------------------FYNFGWKDYGVAS-LTTILD
 .....|..| .. |       |. |  . | |.    ..                ....                    |. .|| |.|| .  ...||
eqnvtvIvmltelve.......lgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslld

MVKVMTFAL----QEGKVAIHCHAGLGRTGVLIACYLV--------FATRMTADQAIIFVRAKRPNSIQTRGQLLCVREFTQFLTPLR
... .  .|    ..|.| .||.||.||.|..||..|.           ...  .|. ..| .||...|| .|.. ..|. ..|   .
fielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk
DSPc Dual specificity phosphatase, catalytic domain 167-290 4.1e-13 44.3 Pfam-A 17-126 (133) alignment 
Range on Protein: 167-290
Range on HMM: 17-126/133.0
HGIKTIINLQRPGEHAscgnPLEQESGFTYLPEAfM-EagiyfynfGWKDYGVASLTTILDMVKvmTFALQEGKVAIHCHAGLGRTGVLIACYLVFATRM
.||. .||...  ...     . ..| ..||    . .         ...  .. |  . ....  ... ...||..|| ||. |.. ||..||    ..
lgitlvinvtkevpnn....naikkseieylrip.ved........etetkiskeleeavefie..kaeqkgkkvlVHCqaGisRSatliiaYlmktknl

TADQAIIFVRAKRPNSIQTRGQLLC
....|. ||. .|..  .. |.|  
slneAyefvkerrskispnagflrq
DSPc Dual specificity phosphatase, catalytic domain 167-290 4.1e-13 44.3 In-house 17-126 (133) alignment 
Range on Protein: 167-290
Range on HMM: 17-126/133.0
HGIKTIINLQRPGEHAscgnPLEQESGFTYLPEAfM-EagiyfynfGWKDYGVASLTTILDMVKvmTFALQEGKVAIHCHAGLGRTGVLIACYLVFATRM
.||. .||...  ...     . ..| ..||    . .         ...  .. |  . ....  ... ...||..|| ||. |.. ||..||    ..
lgitlvinvtkevpnn....naikkseieylrip.ved........etetkiskeleeavefie..kaeqkgkkvlVHCqaGisRSatliiaYlmktknl

TADQAIIFVRAKRPNSIQTRGQLLC
....|. ||. .|..  .. |.|  
slneAyefvkerrskispnagflrq
0049772 (Phosphotyrosine protein) phosphatases II 176-289 5e-22 74.4 In-house 167-270 (314) alignment 
Range on Protein: 176-289
Range on HMM: 167-270/314.0
QrpgehascgnpleqesGFTYLPEAFMEAGIYFYNFGWKDYGVASLTTILDMVKVMTFALQEGKVAIHCHAGLGRTGV-LIACYLVFATRMTADQAIIFV
.                . .| || | ..|| .... . |... .|  ........  | ..|.|..||.|| ||||. ..|.||. . ......|. .|
k................eelydpelferlgikylripvpDgsaplledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedv

RAKRP-----NSIQTRGQLL
|.|||     ..|..  |..
rlkRpinpnpgfieqleqye
subfamily_PRL_pd Subfamily PRL 195-289 4.1e-12 40.4 In-house 45-140 (151) alignment 
Range on Protein: 195-289
Range on HMM: 45-140/151.0
TYLPEAFMEAGIYFYNFGWKDYGVASLTTILDMVKVMTFALQ---EGKVAIHCHAGLGRTGVLIACYLVfATRMTADQAIIFVRAKRPNSIQTRgQLL
||  |.. ..||   .. ..| .| .   . . ....  . .   .  ||.|| |||||. ||.|  |.  . |. ..|. |.| || ..| .. || 
tydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalali.eaGmkyedavefirekrrgainsk.qlk
subfamily_CDKN3_pd Subfamily CDKN3 198-297 5.2e-11 36.5 In-house 92-194 (202) alignment 
Range on Protein: 198-297
Range on HMM: 92-194/202.0
PEAFMEAGIYFYNFGWKDYGVASLTTILDMVKVMTFALQEGK-VAIHCHAGLGRTGVLIACYLVF-ATRMTADQAIIFVRAKR-PNSIQTRGQLLCVREF
 . . .||.  . .   | .| . .. |.... .. .|....   .||. ||||. ..||| |..    .  ..||  .|  .  ..|||  |   ..||
ldlyqqaglivhhypiadglvpdiasclkileelrinlkayrktlvhcygglgrsslviaclllylddtiepkdaidklrdlkgsraiqtvkqynylsef

TQF
 . 
rdk
subfamily_PTPMT1_pd Subfamily PTPMT1 199-298 1.3e-14 49.0 In-house 67-168 (171) alignment 
Range on Protein: 199-298
Range on HMM: 67-168/171.0
EAFMEAGIYFYNFGWKDYG-VASLTTILDMVKVMTFALQEG-KVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKRPNSIQTRGQLLCVREFTQ
| . . |. ....  .|.   ..| .... |....   ..| .| .||.|| ||.. |.||||.  .... ..|. ....||.     . |.  ..|. .
eewkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyee

FL
.|
kl
subfamily_DSP3_pd Subfamily DSP3 200-279 7.1e-10 32.8 In-house 57-139 (162) alignment 
Range on Protein: 200-279
Range on HMM: 57-139/162.0
AFMEAGIYFYNFGWKDYGVASLTTILDM-VKVMTFALQE--GKVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKRP
 . ...| .. .  .|   . | .  .  .| .  ||..  ||| .||..|. |  .|.  ||.   .||. .||  ||.|| 
fykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkRe
CDKN3 Cyclin-dependent kinase inhibitor 3 (CDKN3) 201-270 2.4e-06 18.8 Pfam-A 96-167 (168) alignment 
Range on Protein: 201-270
Range on HMM: 96-167/168.0
FMEAGIYFYNFGWKDYGVASLTTILDMVKVMTFALQE-GKVAIHCHAGLGRTGVLIACYLVFATR-MTADQA
. . ||  .     | |   ... |.... .. .|..  |  |||. ||||. .. || |.. .  .. .||
yqqygivthhhpiadggtpdiascleimeelatclknyrktlihcygglgrsclvaaclllylsdsispeqa
CDKN3 Cyclin-dependent kinase inhibitor 3 (CDKN3) 201-270 2.4e-06 18.8 In-house 96-167 (168) alignment 
Range on Protein: 201-270
Range on HMM: 96-167/168.0
FMEAGIYFYNFGWKDYGVASLTTILDMVKVMTFALQE-GKVAIHCHAGLGRTGVLIACYLVFATR-MTADQA
. . ||  .     | |   ... |.... .. .|..  |  |||. ||||. .. || |.. .  .. .||
yqqygivthhhpiadggtpdiascleimeelatclknyrktlihcygglgrsclvaaclllylsdsispeqa
subfamily_DSP23_pd Subfamily DSP23 205-298 1.4e-17 58.7 In-house 51-145 (148) alignment 
Range on Protein: 205-298
Range on HMM: 51-145/148.0
GIYFYNFGWKDYGVASLTTILDMVKVMTFALQEG-KVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKRPNSIQTRGQLLCVREFTQFL
.. ..... .||   .|  . ..|.|.  | . .  |..||  | |||| ..|||||   ...| .||  || .|| |..|  |   ||..  |.
nltlvrlriddyhppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsvetveqeklvrdyetfi
0046845 (Phosphotyrosine protein) phosphatases II 206-296 3.7e-20 67.9 In-house 168-271 (284) alignment 
Range on Protein: 206-296
Range on HMM: 168-271/284.0
IYFYNFGWKDYGVA-SLTTILDMVKVMTFALQ----EGKVAIHCHAGLGRTGVLIACYLVFAT--------RMTADQAIIFVRAKRPNSIQTRGQLLCVR
..|. ..| |.||  |.. .|.... .  .|.    .|....||.||.||||..||..|..          .... .|. ..| .||...||  |.. | 
thfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvy

EFTQ
|. .
eall
0051299 (Phosphotyrosine protein) phosphatases II 206-292 3.5e-19 64.8 In-house 185-279 (288) alignment 
Range on Protein: 206-292
Range on HMM: 185-279/288.0
IYFYNFGWKDYGVAS-LTTILDMVKVMTFA--LQEGKVAIHCHAGLGRTGVLIACYLV-----FATRMTADQAIIFVRAKRPNSIQTRGQLLCVR
. |. ..| |.|| . .. .||... .  |   ..| |..||.||.||||..||..|.     .  .... .|. ..| .||...||  |.. | 
thfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvy
0048567 (Phosphotyrosine protein) phosphatases II 207-296 8.2e-17 56.0 In-house 39-136 (157) alignment 
Range on Protein: 207-296
Range on HMM: 39-136/157.0
YFYNFGWKDYGVASLTTILDMVKVMTFAL-----QEGKVAIHCHAGL---GRTGVLIACYLVFATRMTADQAIIFVRAKRPNSIQTRGQLLCVREFTQ
..|.  . |.|  .|... . ....   |     .....|.||.|||   |||..||.|||.   ..|...|| ..|  ||.|.  | .   .. ...
lvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyllslynl
PTPc_DSPc_SM00012 208-291 3.4e-11 38.6 In-house 5-99 (105) alignment 
Range on Protein: 208-291
Range on HMM: 5-99/105.0
FYNFGWKDYGVAS-LTTILDMVKVMTFALQ----EGKVAIHCHAGLGRTGVLIACYLVFATRMT------ADQAIIFVRAKRPNSIQTRGQLLCV
..  ||.| || .  . ||.... .    .    .. | .||.|| ||||...| ...    ..        | .  .| .||...||  | | .
yhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfl
subfamily_PTPRK_pd Subfamily PTPRK 208-290 5.7e-08 26.9 In-house 178-268 (314) alignment 
Range on Protein: 208-290
Range on HMM: 178-268/314.0
FYNFGWKDYGVA-SLTTILDMVKVMTFA--LQEGKVAIHCHAGLGRTGVLIACYLVFAtrMTADQAII-------FVRAKRPNSIQTRGQLLC
|   || |..|  | |..|..|. .      ..|.. .|| || ||||. ||.  |    |   . ..        .|....| ..|  |   
fqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivld..mieregvvdvfnavktlrsrkvnmveteeqykf
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 208-287 4.5e-07 24.2 In-house 183-271 (319) alignment 
Range on Protein: 208-287
Range on HMM: 183-271/319.0
FYNFGWKDYGVA-SLTTILDMVKVMTFALQE---GKVAIHCHAGLGRTGVLIACYLVFaTRMTADQAI-IF-----VRAKRPNSIQTRGQ
|.   | | .|  ..|..||..| .  . ..   | . .|| || ||||  |.   ..  |.  .... .|     .|..|.  .|.  |
fqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldaml.ervkeegvlDvfstvsrlRtqRnimvqrpeq
subfamily_PTPRD_pd Subfamily PTPRD 208-287 7.4e-07 23.2 In-house 182-269 (564) alignment 
Range on Protein: 208-287
Range on HMM: 182-269/564.0
FYNFGWKDYGVASL-TTILDMVKVMTF--ALQEGKVAIHCHAGLGRTGVLIACYLVFaTRMTADQ------AIIFVRAKRPNSIQTRGQ
|.   | | ||    |..||... ..     ..| . .|| || ||||. |.   .   |.....       .. .|..|.  .||. |
FhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividaml.erikeektvDiyqyvkalrkqRnamVqteeQ
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 208-293 8.7e-07 22.6 In-house 94-188 (440) alignment 
Range on Protein: 208-293
Range on HMM: 94-188/440.0
FYNFGWKDYGVASLT-TILDMVKVMTFA---LQEGKVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIF-----VRAKRPNSIQTRGQLLCVRE
..  || | ||  ..  .| |.. .  .     .| . .|| || |||||.||   ..     .||  ||     .| .||. .||  |   |.|
yhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvhe
subfamily_PTPRB_pd Subfamily PTPRB 209-293 6.3e-09 30.3 In-house 184-279 (293) alignment 
Range on Protein: 209-293
Range on HMM: 184-279/293.0
YNF-GWKDYGVASLT-TILDMVKVMTFAL----QEGKVAIHCHAGLGRTGVLIACYLVFATRMTADQ-----AIIFVRAKRPNSIQTRGQLLCVRE
|.|  | |.|| . | |.||.|. .  |.    ... . .|| ||.||||..||   .. .  . |       .. .| .| . .||  | ... .
yhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihq
subfamily_PTPRA_pd Subfamily PTPRA 209-288 7.4e-07 23.3 In-house 197-284 (330) alignment 
Range on Protein: 209-288
Range on HMM: 197-284/330.0
YNFGWKDYGVASLT-TILDMVK-VMTFALQ-EGKVAIHCHAGLGRTGVLIACYLVFAtRMTADQ------AIIFVRAKRPNSIQTRGQL
.  .| | || . .  .|...| | .   |  | . .|| || |||| .|.   |.. |. |..      ..  .|..||. .||  | 
hftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavle.rvkaerkvdvfefvkrlrlqrpqmvqtdeqy
subfamily_Ptp69D_pd Subfamily Ptp69D 209-275 8.3e-07 23.4 In-house 187-257 (307) alignment 
Range on Protein: 209-275
Range on HMM: 187-257/307.0
YN-FGWKDYGVAS-LTTILDMVKVM--TFALQEGKVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIFVR
|.  ||||. |    ...|.... .     |... . .|| || ||.|...|  ...    . |.. ||  
yhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifet
subfamily_Tensin_pd Subfamily Tensin 209-272 1.5e-06 20.8 In-house 73-140 (189) alignment 
Range on Protein: 209-272
Range on HMM: 73-140/189.0
YNFGWKDYGVASLTTILDMVKVMTFALQEG---KVAIHCHAGLGRTGVLIACYLVFATRMTA-DQAII
 .||| |    ||  .  ..| .   |..     |..||. | ||.||....|. ...  .. |.|..
ldfGWPdllaPsleklcsicksldsWlkadpqnvvvvhckGgkgrigvvvsaymkyskisasadaald
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 209-284 1.6e-06 22.4 In-house 180-264 (288) alignment 
Range on Protein: 209-284
Range on HMM: 180-264/288.0
YN-FGWKDYGVA-SLTTILDMVKVMTFALQE--GKVAIHCHAGLGRTGVLIACYLVFATRMTADQ-----AIIFVRAKRPNSIQT
|.  .| | ||  | . .|.... .  | |.  |.. .|| ||.||||. ||   .  .  . |.     ..  .| .|.. .||
yqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqt
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 210-291 4.5e-08 27.6 In-house 185-280 (325) alignment 
Range on Protein: 210-291
Range on HMM: 185-280/325.0
NFGWKDYGV----ASLTTILDMVKVMTFALQ-----EGKVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIF-----VRAKRPNSIQTRGQLLCV
  .|.| ||    |.| .||..|| .   ..      . . .|| ||.|||||.|. | . |  ..  .  ||     .|..||. ..|  |   .
lqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyili
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 210-293 1.4e-07 26.1 In-house 192-284 (298) alignment 
Range on Protein: 210-293
Range on HMM: 192-284/298.0
NFGWKDYGVASL-TTILDMV-KVMTFALQEG--KVAIHCHAGLGRTGVLIACYLVFAtRMTA------DQAIIFVRAKRPNSIQTRGQLLCVRE
 . | | ||..  |..||.. || .   | |   | ..| || ||.|  || . |.  |. .       |... .|.|||...||. |   . |
ftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvle.rvkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiye
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 210-293 1.4e-07 25.6 In-house 193-281 (305) alignment 
Range on Protein: 210-293
Range on HMM: 193-281/305.0
NFGWKDYGVASL-TTILDMVKVMtfALQEGKVAIHCHAGLGRTGVLIAC-YLV---FATRMT--ADQAIIFVRAKRPNSIQTRGQLLCVRE
   | | || .  ..||....        | ...|| ||.|||| ..   |..   .| ..   .|. .  .| .| |||||  | | | .
widwpdrgvpaadlailelleka..rpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhq
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 210-294 1.2e-06 22.9 In-house 144-237 (250) alignment 
Range on Protein: 210-294
Range on HMM: 144-237/250.0
NFGWKDYGVAS-LTTILDMVKVMTFALQ---EGKVAIHCHAGLGRTGVLIACYLVFATRMT-----ADQAIIFVRAKRPNSIQTRGQLLCVREF
 . | | ||    |..|...| .    |   .. | ..| || ||.|  || . |.    .       . |. .|..||...... |   | | 
fvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyei
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 210-288 3.3e-06 20.8 In-house 139-225 (392) alignment 
Range on Protein: 210-288
Range on HMM: 139-225/392.0
NFGWKDYGVASLTT-ILDMVKVMT--FALQEGKVAIHCHAGLGRTGVLIACYLVFA----TRMTAD-QAIIFVRAKRPNSIQTRGQL
   | | .|   |. .| ..| .   |      . ||| ||.|||||.|.   | |    |||    . .  .| |||  .||. | 
ftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqy
subfamily_PTPN12_pd Subfamily PTPN12 211-291 6.4e-09 30.1 In-house 178-269 (290) alignment 
Range on Protein: 211-291
Range on HMM: 178-269/290.0
FGWKDYGVA-SLTTILDMVKVMTFALQ--EGKVAIHCHAGLGRTGVLIACYLVFAT---RMTAD-----QAIIFVRAKRPNSIQTRGQLLCV
  | | ||  | ...|.... .    .  .  ...|| || ||||..||  .|      .....     . .. .| .|.  .||. |   |
taWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelv
Y_phosphatase Protein-tyrosine phosphatase 212-291 1.2e-09 33.3 Pfam-A 142-229 (235) alignment 
Range on Protein: 212-291
Range on HMM: 142-229/235.0
GWKDYGVA-SLTTILDMVKVMTFAL--QEGKVAIHCHAGLGRTGVLIACYLVFATRMT-----ADQAIIFVRAKRPNSIQTRGQLLCV
.|.|.||  | . .||... .      ..|.| .|| || ||||...|  ...    .       |..  .|..||...|.  |.  .
nWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYifl
Y_phosphatase Protein-tyrosine phosphatase 212-291 1.2e-09 33.3 In-house 142-229 (235) alignment 
Range on Protein: 212-291
Range on HMM: 142-229/235.0
GWKDYGVA-SLTTILDMVKVMTFAL--QEGKVAIHCHAGLGRTGVLIACYLVFATRMT-----ADQAIIFVRAKRPNSIQTRGQLLCV
.|.|.||  | . .||... .      ..|.| .|| || ||||...|  ...    .       |..  .|..||...|.  |.  .
nWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYifl
DSPc_SM00195 212-293 4.4e-09 31.4 In-house 167-256 (263) alignment 
Range on Protein: 212-293
Range on HMM: 167-256/263.0
GWKDYGVA-SLTTILDMVKVMTFALQ--EGKVAIHCHAGLGRTGVLIACYLVFAT-----RMTADQAIIFVRAKRPNSIQTRGQLLCVRE
.|.| ||  | . .|.......   .  .| . .||.||.||||....  ..        ..  .. .  .| .||...||. |.| . |
nWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiye
PTPc_SM00194 212-293 4.4e-09 31.4 In-house 167-256 (263) alignment 
Range on Protein: 212-293
Range on HMM: 167-256/263.0
GWKDYGVA-SLTTILDMVKVMTFALQ--EGKVAIHCHAGLGRTGVLIACYLVFAT-----RMTADQAIIFVRAKRPNSIQTRGQLLCVRE
.|.| ||  | . .|.......   .  .| . .||.||.||||....  ..        ..  .. .  .| .||...||. |.| . |
nWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiye
subfamily_PTPN13_pd Subfamily PTPN13 212-291 7.8e-09 30.2 In-house 175-261 (273) alignment 
Range on Protein: 212-291
Range on HMM: 175-261/273.0
GWKDYGVASL-TTILDMVKVMT-FALQEGKVAIHCHAGLGRTGVLIACYLVFA-----TRMTADQAIIFVRAKRPNSIQTRGQLLCV
 | |.|| |  . .| .|. .  .. ..| ...|| ||.||.|.||. . |.      . .   . .  .| .|   .||. | . |
kwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifv
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 212-291 1.2e-07 26.1 In-house 184-272 (318) alignment 
Range on Protein: 212-291
Range on HMM: 184-272/318.0
GWKDYGVA-SLTTILDMVKVMTFAL---QEGKVAIHCHAGLGRTGVLIACYLVFaTRMTADQA------IIFVRAKRPNSIQTRGQLLCV
 | | ||  | ...||.|.  . |    ..| ...|| || ||||| ||   .   |. |..       .  .| .|.  .||. |   .
sWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdill.erikaealvDvfqtvkqlreqrnlmvqtedqyefi
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 212-288 1.2e-07 25.2 In-house 181-265 (515) alignment 
Range on Protein: 212-288
Range on HMM: 181-265/515.0
GWKDYGVAS----LTTILDMVKVMTFALQeGKVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIF-----VRAKRPNSIQTRGQL
.| | ||      |  ..  ||  .  ..   . ||| || |||||.|.   | |   |..   .|     .|.|||  .||. | 
eWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqy
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 212-288 5.9e-07 23.6 In-house 182-266 (315) alignment 
Range on Protein: 212-288
Range on HMM: 182-266/315.0
GWKDYGVA----SLTTILDMVKVMtFALQEGKVAIHCHAGLGRTGVLIACYLVFATRMTADQAI-----IFVRAKRPNSIQTRGQL
.| | ||     ||  ..  ||      .|  . .|| || |||||.|.   | |    ..          .|||||  .||. . 
ewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeey
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 212-290 7.4e-06 19.8 In-house 192-274 (290) alignment 
Range on Protein: 212-290
Range on HMM: 192-274/290.0
GWKDYGVAS-LTTILDMVKVMTfaLQEGKVAIHCHAGLGRTGVLIACY-----LVFATRMTADQAIIFVRAKRPNSIQTRGQLLC
 | |  ||    ..| .....      | |..|| ||.|||| ..|       |.    .   . .  .|  | ||.|   | | 
swpdksvalstlallrtlrilr..kasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqyla
subfamily_PTPN3_pd Subfamily PTPN3 212-290 9.4e-06 19.7 In-house 180-266 (280) alignment 
Range on Protein: 212-290
Range on HMM: 180-266/280.0
GWKDYGVAS-LTTILDMVKVMTFAL--QEGKVAIHCHAGLGRTGVLIACYLVFATRMTA-----DQAIIFVRAKRPNSIQTRGQLLC
 | | || .  . .|..|. .  .   .|  | .|| ||.|||||||.  . .|   .|      . .  .| .| . .|| .|   
aWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykf
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 213-291 5.1e-06 20.7 In-house 162-256 (270) alignment 
Range on Protein: 213-291
Range on HMM: 162-256/270.0
WKDYGVASLTT-------ILDMVKVM---TFALQEG-KVAIHCHAGLGRTGVLIA---CYLVFATRMTADQAII--FVRAKRPNSIQTRGQLLCV
| | || . .        .| |.. .   .  |...  . .|| ||.||||.|||   .  .  ... .| . |   .| .|.. .|.  |   .
WpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyefl
subfamily_VSP_pd Subfamily VSP 213-280 8.4e-06 19.9 In-house 101-172 (212) alignment 
Range on Protein: 213-280
Range on HMM: 101-172/212.0
WKDYGVASLTTILDMVKVMTFALQ---EGKVAIHCHAGLGRTGVLIACYLVFATRM-TADQAIIFVRAKRPN
  |. | .|  .| . | .   |.   .  .||||  | |||| .. ..|. .  . ||.... .   .| .
iddhnvpkleellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtd
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 221-291 3.8e-07 24.5 In-house 201-276 (297) alignment 
Range on Protein: 221-291
Range on HMM: 201-276/297.0
LTTILDMVKVMTFALQEGKVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIF-----VRAKRPNSIQTRGQLLCV
|  ... |.      .|| . .|| ||.||||||..   | |     ..  ||     .| .||. .||. |   |
llklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfv
subfamily_DSP14_pd Subfamily DSP14 229-279 7.7e-06 19.9 In-house 75-125 (157) alignment 
Range on Protein: 229-279
Range on HMM: 75-125/157.0
KVMTFALQEGKVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKRP
|. .   ..||. .|| ||  |   |   ||.   ...  .|   |...||
kieevkkkggktlvhCvaGvSRSAslclaylmkyeklsLreayklvksaRp
subfamily_DSP19_pd Subfamily DSP19 232-281 4e-07 24.5 In-house 83-133 (152) alignment 
Range on Protein: 232-281
Range on HMM: 83-133/152.0
TFALQE-GKVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKRPNS
  |... | | .||.||  |.  ..  ||.  ....  .|.  ||..||. 
eearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpci
subfamily_DSP12_pd Subfamily DSP12 233-280 5e-07 24.2 In-house 77-125 (155) alignment 
Range on Protein: 233-280
Range on HMM: 77-125/155.0
FAL-QEGKVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKRPN
 || .||.| .||.||. |   ... ||.  ...  ..|. .|..|.|.
ealeeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkpe
subfamily_DSP6_pd Subfamily DSP6 234-280 8.8e-06 19.3 In-house 89-136 (158) alignment 
Range on Protein: 234-280
Range on HMM: 89-136/158.0
AL-QEGKVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKRPN
|  .. || .||.||. |.  .. .||.  . .. ..|  .|.....|
arskkskvlvhClaGisrsvtvtlaylmkklalslndaydlvkkrksn
subfamily_DSP1_pd Subfamily DSP1 235-282 2.5e-09 31.4 In-house 93-140 (163) alignment 
Range on Protein: 235-282
Range on HMM: 93-140/163.0
LQEGKVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKRPNSI
 ..||| |||.||. |   |.  ||.  .|.. ..|  ||. .|. . 
kknGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRsiis
subfamily_DSP15_pd Subfamily DSP15 235-294 3.5e-07 24.4 In-house 76-135 (151) alignment 
Range on Protein: 235-294
Range on HMM: 76-135/151.0
LQEGKVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKRPNSIQTRGQLLCVREF
|.|..| .|| ||. |   |.. ||. .| .   .|. ...|.|  .    |    ..|.
lkeenvlvhClaGvsRsvtlvvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkey
subfamily_RNGTT_pd Subfamily RNGTT 236-283 4.5e-09 30.2 In-house 112-159 (189) alignment 
Range on Protein: 236-283
Range on HMM: 112-159/189.0
QEGKVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKRPNSIQ
 |  ...||. |  ||| ||..|||  . . ...|.   .  ||  | 
peevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiy
subfamily_DSP8_pd Subfamily DSP8 236-283 3.5e-07 23.9 In-house 92-138 (159) alignment 
Range on Protein: 236-283
Range on HMM: 92-138/159.0
QEGKVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKRpNSIQ
..|.| .|..||  |   .. .|..   .|. |.|  ||. || ..|.
engrvlvhvlaGisrsatvaiayimktlemsldeayrfvkekr.ptis
subfamily_LRR-DSP_pd Subfamily LRR-DSP 236-286 9.6e-07 22.1 In-house 196-246 (263) alignment 
Range on Protein: 236-286
Range on HMM: 196-246/263.0
QEGKVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKRPNSIQTRG
..| | .|| ||. |.  |. .||.   |..  .|. .|  |||.    .|
kkGGvlvhcraGvsrsstlvisylmkkqrlkfkealdlvikkrpriqPnpG
subfamily_DSP10_pd Subfamily DSP10 237-279 1.7e-07 25.2 In-house 92-134 (159) alignment 
Range on Protein: 237-279
Range on HMM: 92-134/159.0
EGKVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKRP
. .| .||.||. |   ..  ||.  ....  .|  ||. |||
gsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekrp
subfamily_DSP11_pd Subfamily DSP11 238-282 4.8e-06 20.6 In-house 117-161 (178) alignment 
Range on Protein: 238-282
Range on HMM: 117-161/178.0
GKVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKRPNSI
  ...||  |. ||| ||  ||.  . . ...||      |  |.
kligvhCthGvnrtGyliCrylidvegyepedaieafeearGhsl