Gene MTMR10 in Homo sapiens

Synonym: MTMR10

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR10
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP049_AA protein Get Run
HsapP049_AA_221-668 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Myotub-related Myotubularin-like phosphatase domain 175-334 4.9e-27 87.6 Pfam-A 2-142 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 175-334 4.9e-27 87.6 In-house 2-142 (353) alignment
subfamily_MTMR10_pd Subfamily MTMR10 176-335 6.3e-35 112.6 In-house 170-332 (380) alignment 
Range on Protein: 176-335
Range on HMM: 170-332/380.0
FAFEYVGKKYHNSANKINGIPSGDGGGGGGGGNGAGGGSSQKTPLFETYSDWDREIKRTGASG--WRVCSINEGYMISTCLPEYIVVPSSLADQDLKIFS
...... ..... ..| . . . . .| .  .. |.... ...| ..|.|.....|.... ..  ........... ........... ...||.|..|.
lclstasdavktvvekkrsvilqesegrDlscvvaSLaqlmldphyrtisGfqsliqkewvaaghpfldrlghikpseksespvfllFldcvdqlleqfp

HSFV-GRRMPLWCWSHSNGSALVRMALIKDVLQQRKIDQRICNAITKSHPQRSDVYKSDLDKT
..|  ........|..|..... .... ..  ............|.||.....|..|..||..
seFeFtetfLialwdsshsgifltflfnseeqrlkavvsssplliakselkendllkdeldyr
0040695 (Phosphotyrosine protein) phosphatases II 221-666 7.6e-96 315.0 In-house 7-387 (388) alignment 
Range on Protein: 221-666
Range on HMM: 7-387/388.0
FETYSDWDREIKRTGAS--GWRVCSINEGYMISTCLPEYIVVPSSLADQDLKIFSHSFVGRRMPLWCWSHS-NGSALVRMA--LIKDVLQQRKIDQRICN
.... |. ||.||.|..   ||....||.| ... .| ..|||.|. |..|| ... . ..|.| ....|. ||..|.|..  |.. .|.. . |.....
gwslydilrelkrlglgldlwrisivNenyelcpsYPallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplvglllsrsledeklle

AITKSHPQRSDVYKSDLDK----------------------------TLPNIQEVQAAFVKLKQLCVNEPFEEteeKWLSSLENTRWLEYVRAFLKHSAE
||.|..|. | ..  || .                             .|||. |.... || ..|.| |..    ..||.||...||.... .|... .
ailkllpnlskllivdlrpklnalanralgggvenedaypnaeliflnipnihvvreslqklldaclnvpdsl...nllslleesgwldliklilelavl

LVYMLESKHLSVVLQEEEGRDLSCCVASLVQVMLDPYFRTITGFQSLIQKEWVMAGYQFLDRCNH---LKRSEKESPLFLLFLDATWQLLEQYPAAFEFS
.| .|.... ||......|.|. . . ||.|..||||.||. |||.||.|||...|..|.||..|    ..|. .||.||||||..|||| |.| ||||.
ivklldlgnssvlvhcsdgwdrtsqlssLaqllldPyYRTleGFqvLiekeWlsfghkfadRlghleseidskefsPvFllFLdcvwqLlrqfPtaFeFn

ETYLAVLYDSTRISLFGTFLFNSPHQRVKQSTefaiskniqlgdekGLKFPSVWDWSLQFTAKdrtlFHNPFYIGKStpciqngsvksfkrtkksysstl
|..|  |.|.. ...||||||||...|.. |.                .  |.|.. |... .    |.||.|   |                       
erlLlfLadhlyscrfgtFlfnsekerlelsv..............sertlslwsyllsrkse....flnplYdpss.......................

rgmpsalkngiisdqellprrnslilkpkpdpaqqtdsqnsdteqyfrewfskpanlHGVILPRVSGTHIKLWKLCYFRWVP
                                                         . |.|| .|  ...||  .|.||.|
.........................................................levllpslsvldlllWleyylrwlp
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 222-330 2.1e-12 38.9 In-house 20-130 (404) alignment 
Range on Protein: 222-330
Range on HMM: 20-130/404.0
ETYSDWDREIKrTGASGWRVCSINEGYMISTCLPEYIVVPSSLADQDLKIFSHSFVGRRMPLWCWSHS-NGSALVRMALIK-DVLQQR-KIDQRICNAIT
.. ... |    .. | ||. .||  | ..   |...|||.|..|..||  ..     |.|  .| |  ..| ..| .  .  . ..| . | .. |.|.
daeeEykRlgi.kseseWriskinsdyelcetYPkllvvPesisDeelkkvasfRskgRiPvlswrhrsknstitRssqplvGltksrseedEklinsir

KSHPQRSDVYKS
|...| . .|  
kaktqletlyil
subfamily_MTMR3_pd Subfamily MTMR3 225-298 4.8e-09 28.5 In-house 27-104 (442) alignment 
Range on Protein: 225-298
Range on HMM: 27-104/442.0
SDWDREIKRTG---ASGWRVCSINEGYMISTCLPEYIVVPSSLADQDLKIFSHSFVGRRMPLWCWSHS-NGSALVRMA
..   |..| |    . ||. ..|. . . .  |. ..||.|. |.|||  ..    .|.|   | |  ||..|.| .
eklkeeverlGfdlkeawrisdvnsdfklCssyPkklivPksitdddlkkvasfrslkrlPavvwrhkkngavlarcs
subfamily_MTMR6_pd Subfamily MTMR6 226-331 1.5e-06 19.7 In-house 23-132 (397) alignment 
Range on Protein: 226-331
Range on HMM: 23-132/397.0
DWDREIKRTG--ASGWRVCSINEGYMISTCLPEYIVVPSSLAdQDLKIFSHSFVG-RRMPLWCWSH-SNGSALVRMALIKDVLQQRKI-DQRICNAITKS
|.  |..| |   . | ....|. | .    |. ..||.| . ... . |  |   .|.|.  . | .| .|. | .     ...|   |... .||.|.
dlkaeytrmgvpnekwtltdlnkdyelcdtyprelyvPksat.kevlvgsskfrskgrlPvlsylhkeneaaicrcsqplsgfsarcledeklleairka

HPQRSDVYKSD
 |. . .|  |
npnsellyvvd
subfamily_MTMR1_pd Subfamily MTMR1 229-326 2.3e-09 29.0 In-house 14-117 (389) alignment 
Range on Protein: 229-326
Range on HMM: 14-117/389.0
REIKRTGA---SGWRVCSINEGYMISTCLPEYIVVPSSLADQDLKIFSHSFVGRRMPLWCWSHSN-GSALVRMALIKDVLQQR--KIDQRICNAITKSHP
.|..|.|      ||....|. | ..   |. .|||..  |.|||  ..     |.|  .| . . .....| .     |...  | |... .|| ... 
aelerlgllneklWritklnkkyelcdtYpavlvvpkvvsdedlkkvaafrskgRlPvlswlnkenqavilrasqplvGlsgkrskedekylqaileana

QRSD
|.. 
qsek
subfamily_MTMR9_pd Subfamily MTMR9 234-321 3.6e-12 38.1 In-house 29-119 (393) alignment 
Range on Protein: 234-321
Range on HMM: 29-119/393.0
TGASGWRVCSINEGYMISTCLPEYIVVPSSLADQDLKIFSHSFVGRRMPLWCWSH-SNGSALVRM--ALIKDVLQQRKIDQRICNAITKSH
. ...||. |.|... . .  || ..|| .. |..||. ..   | |.|. .. |  ....|.|   .|.    .. | |... |.. |. 
sasdewRissvNknfkvcasypesvivPkaiddeelkasaafreggrfPvLsylhketkavllrssqplcgssgkrckedekllnlvlkkl
subfamily_MTMR5_pd Subfamily MTMR5 237-321 1.1e-13 42.8 In-house 28-116 (483) alignment 
Range on Protein: 237-321
Range on HMM: 28-116/483.0
SG-WRVCSINEGYMISTCLPEYIVVPSSLADQDLKIFSHSFVGRRMPLWCWSHS-NGSALVRMALI--KDVLQQRKIDQRICNAITKSH
.| .|. ..|. | ..   |  |||||.. |. ..  .. |   |.|. .| |. |.. |.| . .  |.|..  |  .   .. ..|.
rgkfrisevNkkytvcrsYPalivvPsevsddsiarvakcfrqnRlPvvtWrhernkalLiRsggfeskgvvgllksantqgsstsess
subfamily_MTMR10_pd Subfamily MTMR10 331-666 2.1e-96 315.0 In-house 118-379 (380) alignment 
Range on Protein: 331-666
Range on HMM: 118-379/380.0
DLDKTLPNIQEVQAAFVKLKQLCVNEPFEE---TEEKWLSSLENTRWLEYVRAFLKHSAELVYMLESKHLSVVLQEEEGRDLSCCVASLVQVMLDPYFRT
|| ..||.||.||.|. ||..|||.. .||   ...|||||||.||||.|||..|... ..| ....|. ||.|||.|||||||.||||.|.||||..||
dlsdelpsiqdvqkaylklreLcvidtseefvtlddkwlssLektrWLayvrlclstasdavktvvekkrsvilqesegrDlscvvaSLaqlmldphyrt

ITGFQSLIQKEWVMAGYQFLDRCNHLKRSEK-ESPLFLLFLDATWQLLEQYPAAFEFSETYLAVLYDSTRISLFGTFLFNSPHQRVKQSTEFAiskniql
|.|||||||||||.||..||||..|.|.||| |||.|||||| ..|||||.|..|||.||.| .|.||.....|.||||||..||.|....         
isGfqsliqkewvaaghpfldrlghikpseksespvfllFldcvdqlleqfpseFeFtetfLialwdsshsgifltflfnseeqrlkavvsss.......

gdekgLKFPSVWDWSLQFTAKDRTLFHNPFYIGKSTPCIQNGSVKSFKRTkksysstlrgmpsalkngiisdqellprrnslilkpkpdpaqqtdsqnsd
     .   .....  ... ||   .... | ..     .  . ||. |.                                                  
.....plliakselkendllkdeldyrqglyaeiiksirrlaaaksylrs..................................................

teqyfrewfskpanlhGVILPRVSGTHIKLWKLCYFRWVP
                 .| |  . . |.||. ||.||||
................eiirPllqipdiqlWdeCYlRWvP
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 334-664 2.6e-52 170.3 In-house 162-402 (404) alignment 
Range on Protein: 334-664
Range on HMM: 162-402/404.0
KTLPNIQEVQAAFVKLKQLCVNepFEETEEKWLSSLENTRWLEYVRAFLKHSAELVYMLESKHLSVVLQEEEGRDLSCCVASLVQVMLDPYFRTITGFQS
... ||.|.. .. |||... .   .| |..||| ||..|||. ..  |. |...| ..|... ||...  .| |  . ..||.|..||||.|||.||..
lnienihelreslkklkkavns..iiekeknwlselessrWldhiklllegskriveliekekssvlvhcsdgwDrtsqlsslsqllldpyyrtiegFiv

LIQKEWVMAGYQFLDRCNH--LKRSEKESPLFLLFLDATWQLLEQYPAAFEFSETYLAVLYDSTRISLFGTFLFNSPHQRVkqstefaiSKNIQLgdekg
||.|||.  |  | .|...   |.|...||.|| |.|. .||..|.|  |||.| .| .. |.   . |||||..| ..|.        ..|..      
liekewlsfGhkfaqRigqttekssdersPiflqFidcvyqltkqfptsFeFnekflikildalyscrfgtFLydsekeRq........qnnlak.....

lKFPSVWDwslqFTAKDRTLFHNPFYIGKSTPCIQNGSVKSFKRTKksysstlrgmpsalkngiisdqellprrnslilkpkpdpaqqtdsqnsdteqyf
 . .|.|        .... . ||.|| ...   .| . .. . ..                                                      
.etvslWa....lleankseylnplyilekkeqkenitssessssa......................................................

rewfskpanlhgvilprvSGTHIKLWKLCYFRW
                  .  .||||.  |.||
..................dikliklWseyylrw
subfamily_MTMR9_pd Subfamily MTMR9 334-514 1e-50 164.9 In-house 157-339 (393) alignment 
Range on Protein: 334-514
Range on HMM: 157-339/393.0
KTLPNIQEVQAAFVKLKQLCVNEPFeeTEEKWLSSLENTRWLEYVRAFLKHSAELVYMLESKHLSVVLQEEEGRDLSCCVASLVQVMLDPYFRTITGFQS
. | .....| ...|| . | .. .  . .|.|| ||.. ||. |.. |. .. .. .|.... .||...||| | .. |.||.|..|||..||. ||..
rslesvasiqdslaklleacsdagl..stdkflsrleksgwlsqvadlleaalvvaqcldeegapvvvhgeeGlDatlqvtsLaqlildpdaRtvrgfea

LIQKEWVMAGYQFLDRCNHLKRSE----KESPLFLLFLDATWQLLEQYPAAFEFSETYLAVLYDSTRISLFGTFLFNSPHQRVKQ
||..||. ||  |  |.... ..|    ...| ||||||. .|.|.|.||.|||.|..| .|.  .  | ||||| .. ..| ..
liereWiqaGHPFasRaskvaaketkkklsgpvfllFLDcvyqilsqfpasFEFneelLillfehsyssqfgtflcdneaerkel
subfamily_MTMR3_pd Subfamily MTMR3 335-516 1.9e-48 158.3 In-house 211-392 (442) alignment 
Range on Protein: 335-516
Range on HMM: 211-392/442.0
TLPNIQEVQAAFVKLKQLCVNEPfeeTEEKWLSSLENTRWLEYVRAFLKHSAELVYMLESKHLSVVLQEEEGRDLSCCVASLVQVMLDPYFRTITGFQSL
 |.||  |. .| .|..|. . |    | .|||.||.|.||. .  .|| ....|  .. .  .|..   .| |    . .| ...||||.||. ||. |
glanihavrksfnslrallsqsp...desnwlsalektkWlqnlsvllkaavkvveavdkegrpvlvhCsdGWdrttqivalakllldpyyrtleGfkvl

IQKEWVMAGYQFLDRCNHLKR---SEKESPLFLLFLDATWQLLEQYPAAFEFSETYLAVLYDSTRISLFGTFLFNSPHQRVKQST
...||.  |..| ||| | .    ..  .|.|| .|||  || .|.|..|||.|..|  |   |  .||||||.|| ..| ....
vereWldfGhkfadrcghgenvddanercPvflqwldavhqlqrqfPtsfefneaflvklvqhtysclfGtflansekereeekv
Myotub-related Myotubularin-like phosphatase domain 336-514 5.2e-71 232.2 Pfam-A 172-353 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 336-514 5.2e-71 232.2 In-house 172-353 (353) alignment
subfamily_MTMR1_pd Subfamily MTMR1 336-516 1.4e-53 174.6 In-house 155-335 (389) alignment 
Range on Protein: 336-516
Range on HMM: 155-335/389.0
LPNIQEVQAAFVKLKQLCVNEpfeETEEKWLSSLENTRWLEYVRAFLKHSAELVYMLESKHLSVVLQEEEGRDLSCCVASLVQVMLDPYFRTITGFQSLI
..||. |.... |||.|.. .     ..||||.||.|.|||.... |. . ..|  .|... ||..  ..| |    . || ...||.|.|||.||. ||
ihnihvvReslkklkelvlpn...vddkkwlsalestkWlehiklilagavkivekvetektsvlvhcsdGWDRtaqltsLamlllDsyyRtieGfevli

QKEWVMAGYQFLDRCNH---LKRSEKESPLFLLFLDATWQLLEQYPAAFEFSETYLAVLYDSTRISLFGTFLFNSPHQRVKQST
.|||.. |..| .|  |    .  ...||.|| |.|. ||| .|.| |||| |..| .| |  . .||||||||| ..|||.. 
ekeWlsfGHkfkeRlghgdknssdaersPvFlqfiDcvwqltrqfptAFefneefLitlldhlysclfGtflfnsekervkekv
subfamily_MTMR5_pd Subfamily MTMR5 336-565 3.6e-47 153.3 In-house 235-463 (483) alignment 
Range on Protein: 336-565
Range on HMM: 235-463/483.0
LPNIQEVQAAFVKLKQLCVNEPF-EETEEK-WLSSLENTRWLEYVRAFLKHSAELVYMLESKHLSVVLQEEEGRDLSCCVASLVQVMLDPYFRTITGFQS
|..|..|.|.| || . |. .   ||.|.. .|.|.|.  ||. ... |. |. .| .|. .  ||..  |.|.|.   |.||.|..||||.||. ||. 
lveirqvkasfkkllraClpstaveeaesqsFlksvedseWlqqissllqlsgavvdlldlqgssvlvslEdGwdvtaqvsslaqllldpyYRtleGFkv

LIQKEWVMAGYQFLDRCNHLKRSEK--ESPLFLLFLDATWQLLEQYPAAFEFSETYLAVLYDSTRISLFGTFLFNSPHQRVKQSTefAIS-KNIQLGDEK
|..|||.  |..| .|.|. . ...   .| || |||. .|. .|.| ||||.. || .|        | |||..| ..|.....   .. |. .  .. 
LveKEWLafGHrFtkrsnqtlsaqssgfaPvFlqFLDcvhqvsrqfPlafefndfylkflayhsvsnrfrtfllDseyerlesgl..lyeekaekrakka

GlkfPSVWDWsLQFTAKDRTLFHNPFYIGKSTPCI
|    ||||. .. . |  ..|.|  | ....  .
g...ksvwdy.idrqhkrspifynflyspdesevl
subfamily_pats1_pd Subfamily pats1 336-456 1.8e-18 58.3 In-house 343-463 (691) alignment 
Range on Protein: 336-456
Range on HMM: 343-463/691.0
LPNIQEVQAAFVKLKQLCVNepFEETEEKWlSSLENTRWLEYVRAFLKHSAELVYMLEsKHLSVVLQEEE-GR--DLSC-CVASLVQVMLDPYFRTITGF
||  ..|.. | .| |  ..  .......| ...|.  |.. |. .|. . ..  .|. .  ||.|..   .   .|   ...|| ||..||..||. ||
lPtrekveerffdllqsils..ldgsddew.keieeskwvdsvkllleaavkvsnlld.eGssvllknsidsPlieldlasisslaqvlsdPfyrtldGf

QSLIQKEWVMAGYQFLDRCNHLKRS
. ||.|||.  |. | ... | .. 
kvliekewlsyGfPfskinyhkesd
subfamily_MTMR6_pd Subfamily MTMR6 338-514 5.8e-43 139.6 In-house 167-342 (397) alignment 
Range on Protein: 338-514
Range on HMM: 167-342/397.0
NIQEVQAAFVKLKQLCVNEpfEETEEKWLSSLENTRWLEYVRAFLKHSAELVYMLESKHLSVVLQEEEGRDLSCCVASLVQVMLDPYFRTITGFQSLIQK
||  ....  || . . ..   .. ...||.||.. || ...| |. |. .  ...... ||..   .| | .. |.|| ...||||.||| ||. ||.|
nihvmreslqkllevvelk..sksvseflsglessgwlkhikavldasifiakavaeegasvlvhcsdGwdrtaqvcslasllldpyyrtikGflvliek

EWVMAGYQFLDRCNHLKRSEKE-SPLFLLFLDATWQLLEQYPAAFEFSETYLAVLYDSTRISLFGTFLFNSPHQRVKQ
||.  |..| .|| .|. ..|| ||.|. ||...||||||.| ||||.|..|  | |    . ||||| |. ..| ..
ewlsfGhkfsercGlldedskevsPiftqflecvwqlleqfpkafefnerfllelhdhvyscqfGtflgncekdrrdl
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 358-518 6.8e-33 106.0 In-house 196-356 (405) alignment 
Range on Protein: 358-518
Range on HMM: 196-356/405.0
FEETEEKWLSSLENTRWLEYVRAFLKhSAELVYMLESKHLSVVLQEEEGRDLSCCVASLVQVMLDPYFRTITGFQSLIQKEWVMAGYQFLDRCNHLKRSE
 | |. ..   .|.| |. .... |. .| .   |  |  |....  .| | .  ..|| |..||||.|||.||| ||.|||.  |..|  |  ||   |
testdmrfwgyieetgwishiksile.aatfsaelilkgnsilvhcsdgwdrtpqitsltqilldpyyrtivgfqvliekewlsfghkfslrlghlpgne

KE-SPLFLLFLDATWQLLEQYPAAFEFSETYLAVLYDSTRISLFGTFLFNSPHQRVKQSTEF
.| ||.|  |||. .|||.|.|  |||. . | .. |      .|||| |  ..||..   .
eerspifqqfldccfqllsqfpllfeftpslllfisdnihsckygtflnncekdrvqdqvkt
subfamily_pats1_pd Subfamily pats1 460-513 3.8e-12 37.4 In-house 553-606 (691) alignment 
Range on Protein: 460-513
Range on HMM: 553-606/691.0
SPLFLLFLDATWQLLEQYPAAFEFSETYLAVLYDSTRISLFGTFLFNSPHQRVK
||.|. |||. |||  ..|  ||| | .| .| . .  | ||.||..   ... 
sPifvqfldlvwqlqkefPfhfefneslllllvkesfssrfGnflyseakrdse
3-PAP Myotubularin-associated protein 574-708 3.1e-40 127.7 Pfam-A 2-140 (142) alignment 
Range on Protein: 574-708
Range on HMM: 2-140/142.0
KRTKKSYSSTLRGMPSALKNGIISDQELLPRRNSLILKPKPDP----AQQTDSQNSDTEQYFREWFSKPANLHGVILPRVSGTHIKLWKLCYFRWVPEAQ
||... |.|..|..|.  ...  ...| ......|.|| ...     .. ..|...  ||......|.||.||...||. .|....||. ||.||.|||.
krslryygsfarslpwkhrrsvavagesseapdllllkllisllsdcsvsspspataseqlsktassvPadlhqlLlpqqlgldlslWsqcylRwiPeae

ISLGGSITAFHKLSLLADEVDVLSRMLRQQRSGPLEACY
|. ||......|||.|..|.  |.|.|.|..  .|....
ikgggqvqvdlklselleeiaklqrlleqrdmsdlpean