Gene MTMR12 in Homo sapiens

Synonym: 3-PAP, PIP3AP, MTMR12

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR10
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP051_AA protein Get Run
HsapP051_AA_203-670 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Myotubularin-like phosphatase domain 182-280 2.5e-11 35.9 Pfam-A 3-102 (353) alignment
Myotubularin-like phosphatase domain 182-280 2.5e-11 35.9 In-house 3-102 (353) alignment
0040695 (Phosphotyrosine protein) phosphatases II 200-668 1.4e-86 284.6 In-house 2-387 (388) alignment
Range on Protein: 200-668
Range on HMM: 2-387/388.0
NHTVMFDTLKDWCWELERT-KGNMKYKAVSVNEGYKVCERLPAYFVVPTPLPEENVQR----FQGHGIPIWCWSCH-NGSALLKMSALPKEQDDGILQIQ
...... .| |...||.|.  |.  .. ..|||.|..|...||..|||. . .| ..|    .... ||....... ||..||..| .   .  .  . .
llleegwslydilrelkrlglgldlwrisivNenyelcpsYPallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplvglllsrsled

KSFLDGIYKTIHRPPY----------EIVKT----------------EDLSSNFLSLQEIQTAYSKFKQLFlidnstEF----WdtdiKWFSLLESSSWL
. .|. |.|.......           .. .                | .. |. ... .. .. |. ...                 ...||||.|.||
eklleailkllpnlskllivdlrpklnalanralgggvenedaypnaeliflnipnihvvreslqklldac......lnvpdsl....nllslleesgwl

DIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISSLVQLMMDPHCRTRIGFQSLIQKEWVMGGHCFLDRCNHLRQ--NDKEEVPVFLLFLDCVWQ
|.|...|. |..|..... .|..||. ...  |.....|||.||..||..||  |||.||.|||.. ||.|.||..|| .  ..||..||||||||||||
dliklilelavlivklldlgnssvlvhcsdgwdrtsqlssLaqllldPyYRTleGFqvLiekeWlsfghkfadRlghleseidskefsPvFllFLdcvwq

LVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQKDTNMGregqdtqskPLNLLTVWDWSVQFEPKaqtlLKNPLYVEKPkldkgqrkgmrfklcl
|..|.| ||||.|..|. | |.||...|.||.|||.... ..           . ..|..|.. .... .    ..||||   .                
LlrqfPtaFeFnerlLlfLadhlyscrfgtFlfnsekerlelsv.........sertlslwsyllsrkse....flnplYdpss................

qaqnfsptestkeravmhqrqlslpltqsksspkrgffreetdhliknllgkrisklinssdelqdnfrefydswhskstdyHGLLLPHIEGPEIKVWAQ
                                                                                  . .|||... .....| .
..................................................................................levllpslsvldlllWle

RYLRWIP
 ||||.|
yylrwlp

subfamily_MTMR10_pd Subfamily MTMR10 205-668 2.3e-111 364.2 In-house 7-379 (380) alignment
Range on Protein: 205-668
Range on HMM: 7-379/380.0
FDTLKDWCWELERTKGNMKYKAVSVNEGYKVCERLPAYFVVPTPLPEENVQRFQGH----GIPIWCWSCHNGSALLKMSALPKEQDDgILQIQKSFLDGI
. .. ... | |. . ....... .||  .... || |||||  | ...|.|   |      |.|.||  .|.||| .||| . ..   .....  |  .
wrselerleekekktvsdaivvllknelfaaaqtlPqyfvvpnslsdsdverlsrhykesRfplwvwshakgaallrlsalqeaesa.dkekeekmlelv

YKTIHRPpyeIVKTEDLSSNFLSLQEIQTAYSKFKQLFLIDNSTEFWDTDIKWFSLLESSSWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCL
 |..       ||  ||| .  |.|..|.||.|...|..||.|.||...| ||.|.||...||...| ||..|........ ....|.| |.. .||.|.
rkchpan...dvklvdlsdelpsiqdvqkaylklreLcvidtseefvtlddkwlssLektrWLayvrlclstasdavktvvekkrsvilqesegrDlscv

ISSLVQLMMDPHCRTRIGFQSLIQKEWVMGGHCFLDRCNHLRQNDKEEVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQK
..||.|||.|||.||  |||||||||||..||.||||..|. ...|.| ||||||||||.||..|.| .||||||.|..| || ...||.||.|||..|.
vaSLaqlmldphyrtisGfqsliqkewvaaghpfldrlghikpseksespvfllFldcvdqlleqfpseFeFtetfLialwdsshsgifltflfnseeqr

DTNMGREGqdtqskpLNLLTVWDWSVQFEPKAQTLLKNPLYVEKPKLDKGQRKGMRFKLClqaqnfsptestkeravmhqrqlslpltqsksspkrgffr
 ...   .       ..|......  ..  | .   ...|| |. |  . .  .  .  .                                        
lkavvsss.......plliakselkendllkdeldyrqglyaeiiksirrlaaaksylrs........................................

eetdhliknllgkrisklinssdelqdnfrefydswhskstdyhGLLLPHIEGPEIKVWAQRYLRWIP
                                             .. |  . |.|..| . ||||.|
............................................eiirPllqipdiqlWdeCYlRWvP

subfamily_MTMR5_pd Subfamily MTMR5 220-283 1.5e-08 25.9 In-house 27-95 (483) alignment
Range on Protein: 220-283
Range on HMM: 27-95/483.0
GNMKYKAVSVNEGYKVCERLPAYFVVPTPLPEENVQR----FQGHGIPIWCWSCH-NGSALLKMSALPK
 . |..  .||. |.||.  || .|||. . .....|    |. . .|. .|  . |.. |.. ... .
krgkfrisevNkkytvcrsYPalivvPsevsddsiarvakcfrqnRlPvvtWrhernkalLiRsggfes

subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 309-666 8.1e-46 149.0 In-house 148-402 (404) alignment
Range on Protein: 309-666
Range on HMM: 148-402/404.0
YE-IVKTEDLSSNFLSLQEIQTAYSKFKQLFLIDNSTEfwDTDIKWFSLLESSSWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISSLVQL
|| | . |. . .||....|..    .|.|. . ||..  . . .|.| |||| ||| |.. |. . .| | .| .. .||.   .  |  . .|||.||
yedisryenceieflnienihelreslkklkkavnsii..ekeknwlselessrWldhiklllegskriveliekekssvlvhcsdgwDrtsqlsslsql

MMDPHCRTRIGFQSLIQKEWVMGGHCFLDRCNH-LRQNDKEEVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQKDtnmgr
..||. ||  ||..||.|||.  ||.| .|...   ....|. |.|| |.|||.||..|.|  ||| | .|... |.||   | || ..| ...      
lldpyyrtiegFivliekewlsfGhkfaqRigqttekssdersPiflqFidcvyqltkqfptsFeFnekflikildalyscrfgtFLydsekeRq.....

egqdTQSKPLNLLTVWDwsvQFEPKAqTLLKNPLYVEKPKLDKGQRKGMRFKLCLqaqnfsptestkeravmhqrqlslpltqsksspkrgffreetdhl
     . .. ..  .|      | .  . . ||||. . |  | . .    ..                                               
....qnnlaketvslWa...lleank.seylnplyilekkeqkenitssessssa.............................................

iknllgkrisklinssdelqdnfrefydswhskstdyhglllphiEGPEIKVWAQRYLRW
                                             .  .||.| . ||||
.............................................dikliklWseyylrw

subfamily_MTMR6_pd Subfamily MTMR6 317-502 1.7e-39 128.2 In-house 158-341 (397) alignment
Range on Protein: 317-502
Range on HMM: 158-341/397.0
LSSNFLSLQEIQTAYSKFKQLflIDNSTEFWDTDIKWFSLLESSSWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISSLVQLMMDPHCRTR
.  .|.....| .  .  ..|  .. . .   .  ...| ||||.||  |.  |. .| |.. .. ....||.   .  |  . . || .|..||. || 
ikfqfvgienihvmreslqkl..levvelksksvseflsglessgwlkhikavldasifiakavaeegasvlvhcsdGwdrtaqvcslasllldpyyrti

IGFQSLIQKEWVMGGHCFLDRCNHLRQNDKEEVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQKDT
 ||. ||.|||.  || | .|| .| .. ||  |.|. ||.|||||..|.| |||| |..|  | | .|   | ||. |. ...  
kGflvliekewlsfGhkfsercGlldedskevsPiftqflecvwqlleqfpkafefnerfllelhdhvyscqfGtflgncekdrrd

subfamily_pats1_pd Subfamily pats1 318-446 2e-16 51.6 In-house 337-465 (691) alignment
Range on Protein: 318-446
Range on HMM: 337-465/691.0
SSNFLSLQEIQTAYSKFKQLFliDNSTEFWDTDIKWFSLlESSSWLDIIRRCLKKAIEITECMEaQNMNVLLLEENASDLCCL----ISSLVQLMMDPHC
   ||||   .    .| .|.  .. ... ..| .| .. | | |.| ..  |. |....  .. .   ||| .   | |  |    |||| |...||. 
niiflslPtrekveerffdll..qsilsldgsddewkei.eeskwvdsvkllleaavkvsnlld.eGssvllknsidsPlieldlasisslaqvlsdPfy

RTRIGFQSLIQKEWVMGGHCFLDRCNHLRQNDK
||  ||. ||.|||.  |. | ... |  ..| 
rtldGfkvliekewlsyGfPfskinyhkesddl

subfamily_MTMR5_pd Subfamily MTMR5 319-531 1.6e-39 128.0 In-house 233-446 (483) alignment
Range on Protein: 319-531
Range on HMM: 233-446/483.0
SNFLSLQEIQTAYSKFKQLFLIDNSTEfwDTDIK-WFSLLESSSWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISSLVQLMMDPHCRTRI
 ..   ....... |. .  | ....|  ... . . ...| | ||  |.. |. .  ... ...|.  ||.  |. .|.   .|||.||..||. ||  
velveirqvkasfkkllraClpstave..eaesqsFlksvedseWlqqissllqlsgavvdlldlqgssvlvslEdGwdvtaqvsslaqllldpyYRtle

GFQSLIQKEWVMGGHCFLDRCNHLRQNDK-EEVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQKDT-NMGREGQDTQSKP
||. |..|||.  || | .|.|.  .. .    |||| |||||.|. .|.| |||| . ||..|.       | ||...| ...   .. .| . .. . 
GFkvLveKEWLafGHrFtkrsnqtlsaqssgfaPvFlqFLDcvhqvsrqfPlafefndfylkflayhsvsnrfrtfllDseyerlesgllyeekaekrak

LNLLTVWDWSVQFEPK
    .|||.  . ...
kagksvwdyidrqhkr

Myotubularin-like phosphatase domain 321-501 1.4e-53 174.9 Pfam-A 169-351 (353) alignment
Myotubularin-like phosphatase domain 321-501 1.4e-53 174.9 In-house 169-351 (353) alignment
subfamily_MTMR3_pd Subfamily MTMR3 321-504 8.2e-39 126.6 In-house 209-391 (442) alignment
Range on Protein: 321-504
Range on HMM: 209-391/442.0
FLSLQEIQTAYSKFKQLFLIDNSTefwDTDIKWFSLLESSSWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISSLVQLMMDPHCRTRIGFQ
||.|  | .  . |..|  . ...     ...|.| ||. .||  .   ||.|....| .. ..  ||.   .  |    | .| .|..||. ||  ||.
flglanihavrksfnslrallsqs...pdesnwlsalektkWlqnlsvllkaavkvveavdkegrpvlvhCsdGWdrttqivalakllldpyyrtleGfk

SLIQKEWVMGGHCFLDRCNHLRQND--KEEVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQKDTNM
 |...||.  || | ||| |  . |  .|  |||| .||.| || .|.| .|||.|..|  |    |  .| ||..|| ... .. 
vlvereWldfGhkfadrcghgenvddanercPvflqwldavhqlqrqfPtsfefneaflvklvqhtysclfGtflansekereeek

subfamily_MTMR9_pd Subfamily MTMR9 339-504 6.7e-46 149.1 In-house 172-340 (393) alignment
Range on Protein: 339-504
Range on HMM: 172-340/393.0
LIDNSTEFWDTDIKWFSLLESSSWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISSLVQLMMDPHCRTRIGFQSLIQKEWVMGGHCFLDRC
|..  ..   .  |..| ||.| ||. ..  |. |  ...|.. ... |.. .|.  |  . ..||.||..||..||  ||..||..||. .|| |  |.
lleacsdaglstdkflsrleksgwlsqvadlleaalvvaqcldeegapvvvhgeeGlDatlqvtsLaqlildpdaRtvrgfealiereWiqaGHPFasRa

NHLRQND---KEEVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQKDTNM
...  ..   |.. ||||||||||.|...|.| .||| |..|..|    |   |.||  .. ...... 
skvaaketkkklsgpvfllFLDcvyqilsqfpasFEFneelLillfehsyssqfgtflcdneaerkelk

subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 348-498 1.3e-29 95.2 In-house 198-347 (405) alignment
Range on Protein: 348-498
Range on HMM: 198-347/405.0
DTDIKWFSLLESSSWLDIIRRCLKKAIEITECMEAQNmNVLLLEENASDLCCLISSLVQLMMDPHCRTRIGFQSLIQKEWVMGGHCFLDRCNHLRQNDKE
 ||....  .| . |.  |.  |. |   .| .   |  .|.   .  |    |.|| |...||. ||  ||| ||.|||.  || |  |  ||  |..|
stdmrfwgyieetgwishiksileaatfsaelilkgn.silvhcsdgwdrtpqitsltqilldpyyrtivgfqvliekewlsfghkfslrlghlpgneee

EVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPH
  |.|  ||||..||. | |  |||| . | ..|| ..   . ||. |  .
rspifqqfldccfqllsqfpllfeftpslllfisdnihsckygtflnncek

subfamily_MTMR1_pd Subfamily MTMR1 349-502 6.9e-45 146.0 In-house 177-332 (389) alignment
Range on Protein: 349-502
Range on HMM: 177-332/389.0
TDIKWFSLLESSSWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISSLVQLMMDPHCRTRIGFQSLIQKEWVMGGHCFLDRCNH--LRQNDK
 | ||.| |||. ||. |.  |. |..| |..| ....||.  ..  |    . || .|..|.. ||  ||. ||.|||.. || | .|  |    ..|.
ddkkwlsalestkWlehiklilagavkivekvetektsvlvhcsdGWDRtaqltsLamlllDsyyRtieGfevliekeWlsfGHkfkeRlghgdknssda

EEVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQKDT
|. |||| |.|||||| .|.| ||||.|..| .| | ||  .| || ||| ...  
ersPvFlqfiDcvwqltrqfptAFefneefLitlldhlysclfGtflfnsekervk

subfamily_pats1_pd Subfamily pats1 450-499 1.7e-09 28.6 In-house 554-603 (691) alignment
Range on Protein: 450-499
Range on HMM: 554-603/691.0
PVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQ
|.|. ||| |||| .. |  ||| | .| .| .  .   | .|...   .
PifvqfldlvwqlqkefPfhfefneslllllvkesfssrfGnflyseakr

3-PAP Myotubularin-associated protein 579-706 2.3e-39 124.9 Pfam-A 1-136 (142) alignment
Range on Protein: 579-706
Range on HMM: 1-136/142.0
HQRQL--------SLPLTQSKSSPKRGFFREETDHLIKNLLGKRISKLINSSDELQDNFREFYDSWHSKSTDYHGLLLPHIEGPEIKVWAQRYLRWIPEA
|.|.|        ||| ....|....|.. |..|.|...|| ...|.. .||.. ............|...|.|.||||.  |.....| |.||||||||
hkrslryygsfarslpwkhrrsvavagesseapdllllkllisllsdcsvsspspataseqlsktassvPadlhqlLlpqqlgldlslWsqcylRwiPea

QILGGGQVATLSKLLEMMEEVQSLQEKIDERHHSQQ
.| |||||.. .||.|..||...||.....|..|. 
eikgggqvqvdlklselleeiaklqrlleqrdmsdl