Gene MTMR12 in Homo sapiens

Synonym: 3-PAP, PIP3AP, MTMR12

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR10
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP051_AA protein Get Run
HsapP051_AA_203-670 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Myotub-related Myotubularin-like phosphatase domain 182-280 2.5e-11 35.9 Pfam-A 3-102 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 182-280 2.5e-11 35.9 In-house 3-102 (353) alignment
0040695 (Phosphotyrosine protein) phosphatases II 200-668 1.4e-86 284.6 In-house 2-387 (388) alignment 
Range on Protein: 200-668
Range on HMM: 2-387/388.0
NHTVMFDTLKDWCWELERT-KGNMKYKAVSVNEGYKVCERLPAYFVVPTPLPEENVQR----FQGHGIPIWCWSCH-NGSALLKMSALPKEQDDGILQIQ
...... .| |...||.|.  |.  .. ..|||.|..|...||..|||. . .| ..|    .... ||....... ||..||..| .   .  .  . .
llleegwslydilrelkrlglgldlwrisivNenyelcpsYPallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplvglllsrsled

KSFLDGIYKTIHRPPY----------EIVKT----------------EDLSSNFLSLQEIQTAYSKFKQLFlidnstEF----WdtdiKWFSLLESSSWL
. .|. |.|.......           .. .                | .. |. ... .. .. |. ...                 ...||||.|.||
eklleailkllpnlskllivdlrpklnalanralgggvenedaypnaeliflnipnihvvreslqklldac......lnvpdsl....nllslleesgwl

DIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISSLVQLMMDPHCRTRIGFQSLIQKEWVMGGHCFLDRCNHLRQ--NDKEEVPVFLLFLDCVWQ
|.|...|. |..|..... .|..||. ...  |.....|||.||..||..||  |||.||.|||.. ||.|.||..|| .  ..||..||||||||||||
dliklilelavlivklldlgnssvlvhcsdgwdrtsqlssLaqllldPyYRTleGFqvLiekeWlsfghkfadRlghleseidskefsPvFllFLdcvwq

LVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQKDTNMGregqdtqskPLNLLTVWDWSVQFEPKaqtlLKNPLYVEKPkldkgqrkgmrfklcl
|..|.| ||||.|..|. | |.||...|.||.|||.... ..           . ..|..|.. .... .    ..||||   .                
LlrqfPtaFeFnerlLlfLadhlyscrfgtFlfnsekerlelsv.........sertlslwsyllsrkse....flnplYdpss................

qaqnfsptestkeravmhqrqlslpltqsksspkrgffreetdhliknllgkrisklinssdelqdnfrefydswhskstdyHGLLLPHIEGPEIKVWAQ
                                                                                  . .|||... .....| .
..................................................................................levllpslsvldlllWle

RYLRWIP
 ||||.|
yylrwlp
subfamily_MTMR10_pd Subfamily MTMR10 205-668 2.3e-111 364.2 In-house 7-379 (380) alignment 
Range on Protein: 205-668
Range on HMM: 7-379/380.0
FDTLKDWCWELERTKGNMKYKAVSVNEGYKVCERLPAYFVVPTPLPEENVQRFQGH----GIPIWCWSCHNGSALLKMSALPKEQDDgILQIQKSFLDGI
. .. ... | |. . ....... .||  .... || |||||  | ...|.|   |      |.|.||  .|.||| .||| . ..   .....  |  .
wrselerleekekktvsdaivvllknelfaaaqtlPqyfvvpnslsdsdverlsrhykesRfplwvwshakgaallrlsalqeaesa.dkekeekmlelv

YKTIHRPpyeIVKTEDLSSNFLSLQEIQTAYSKFKQLFLIDNSTEFWDTDIKWFSLLESSSWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCL
 |..       ||  ||| .  |.|..|.||.|...|..||.|.||...| ||.|.||...||...| ||..|........ ....|.| |.. .||.|.
rkchpan...dvklvdlsdelpsiqdvqkaylklreLcvidtseefvtlddkwlssLektrWLayvrlclstasdavktvvekkrsvilqesegrDlscv

ISSLVQLMMDPHCRTRIGFQSLIQKEWVMGGHCFLDRCNHLRQNDKEEVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQK
..||.|||.|||.||  |||||||||||..||.||||..|. ...|.| ||||||||||.||..|.| .||||||.|..| || ...||.||.|||..|.
vaSLaqlmldphyrtisGfqsliqkewvaaghpfldrlghikpseksespvfllFldcvdqlleqfpseFeFtetfLialwdsshsgifltflfnseeqr

DTNMGREGqdtqskpLNLLTVWDWSVQFEPKAQTLLKNPLYVEKPKLDKGQRKGMRFKLClqaqnfsptestkeravmhqrqlslpltqsksspkrgffr
 ...   .       ..|......  ..  | .   ...|| |. |  . .  .  .  .                                        
lkavvsss.......plliakselkendllkdeldyrqglyaeiiksirrlaaaksylrs........................................

eetdhliknllgkrisklinssdelqdnfrefydswhskstdyhGLLLPHIEGPEIKVWAQRYLRWIP
                                             .. |  . |.|..| . ||||.|
............................................eiirPllqipdiqlWdeCYlRWvP
subfamily_MTMR5_pd Subfamily MTMR5 220-283 1.5e-08 25.9 In-house 27-95 (483) alignment 
Range on Protein: 220-283
Range on HMM: 27-95/483.0
GNMKYKAVSVNEGYKVCERLPAYFVVPTPLPEENVQR----FQGHGIPIWCWSCH-NGSALLKMSALPK
 . |..  .||. |.||.  || .|||. . .....|    |. . .|. .|  . |.. |.. ... .
krgkfrisevNkkytvcrsYPalivvPsevsddsiarvakcfrqnRlPvvtWrhernkalLiRsggfes
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 309-666 8.1e-46 149.0 In-house 148-402 (404) alignment 
Range on Protein: 309-666
Range on HMM: 148-402/404.0
YE-IVKTEDLSSNFLSLQEIQTAYSKFKQLFLIDNSTEfwDTDIKWFSLLESSSWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISSLVQL
|| | . |. . .||....|..    .|.|. . ||..  . . .|.| |||| ||| |.. |. . .| | .| .. .||.   .  |  . .|||.||
yedisryenceieflnienihelreslkklkkavnsii..ekeknwlselessrWldhiklllegskriveliekekssvlvhcsdgwDrtsqlsslsql

MMDPHCRTRIGFQSLIQKEWVMGGHCFLDRCNH-LRQNDKEEVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQKDtnmgr
..||. ||  ||..||.|||.  ||.| .|...   ....|. |.|| |.|||.||..|.|  ||| | .|... |.||   | || ..| ...      
lldpyyrtiegFivliekewlsfGhkfaqRigqttekssdersPiflqFidcvyqltkqfptsFeFnekflikildalyscrfgtFLydsekeRq.....

egqdTQSKPLNLLTVWDwsvQFEPKAqTLLKNPLYVEKPKLDKGQRKGMRFKLCLqaqnfsptestkeravmhqrqlslpltqsksspkrgffreetdhl
     . .. ..  .|      | .  . . ||||. . |  | . .    ..                                               
....qnnlaketvslWa...lleank.seylnplyilekkeqkenitssessssa.............................................

iknllgkrisklinssdelqdnfrefydswhskstdyhglllphiEGPEIKVWAQRYLRW
                                             .  .||.| . ||||
.............................................dikliklWseyylrw
subfamily_MTMR6_pd Subfamily MTMR6 317-502 1.7e-39 128.2 In-house 158-341 (397) alignment 
Range on Protein: 317-502
Range on HMM: 158-341/397.0
LSSNFLSLQEIQTAYSKFKQLflIDNSTEFWDTDIKWFSLLESSSWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISSLVQLMMDPHCRTR
.  .|.....| .  .  ..|  .. . .   .  ...| ||||.||  |.  |. .| |.. .. ....||.   .  |  . . || .|..||. || 
ikfqfvgienihvmreslqkl..levvelksksvseflsglessgwlkhikavldasifiakavaeegasvlvhcsdGwdrtaqvcslasllldpyyrti

IGFQSLIQKEWVMGGHCFLDRCNHLRQNDKEEVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQKDT
 ||. ||.|||.  || | .|| .| .. ||  |.|. ||.|||||..|.| |||| |..|  | | .|   | ||. |. ...  
kGflvliekewlsfGhkfsercGlldedskevsPiftqflecvwqlleqfpkafefnerfllelhdhvyscqfGtflgncekdrrd
subfamily_pats1_pd Subfamily pats1 318-446 2e-16 51.6 In-house 337-465 (691) alignment 
Range on Protein: 318-446
Range on HMM: 337-465/691.0
SSNFLSLQEIQTAYSKFKQLFliDNSTEFWDTDIKWFSLlESSSWLDIIRRCLKKAIEITECMEaQNMNVLLLEENASDLCCL----ISSLVQLMMDPHC
   ||||   .    .| .|.  .. ... ..| .| .. | | |.| ..  |. |....  .. .   ||| .   | |  |    |||| |...||. 
niiflslPtrekveerffdll..qsilsldgsddewkei.eeskwvdsvkllleaavkvsnlld.eGssvllknsidsPlieldlasisslaqvlsdPfy

RTRIGFQSLIQKEWVMGGHCFLDRCNHLRQNDK
||  ||. ||.|||.  |. | ... |  ..| 
rtldGfkvliekewlsyGfPfskinyhkesddl
subfamily_MTMR5_pd Subfamily MTMR5 319-531 1.6e-39 128.0 In-house 233-446 (483) alignment 
Range on Protein: 319-531
Range on HMM: 233-446/483.0
SNFLSLQEIQTAYSKFKQLFLIDNSTEfwDTDIK-WFSLLESSSWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISSLVQLMMDPHCRTRI
 ..   ....... |. .  | ....|  ... . . ...| | ||  |.. |. .  ... ...|.  ||.  |. .|.   .|||.||..||. ||  
velveirqvkasfkkllraClpstave..eaesqsFlksvedseWlqqissllqlsgavvdlldlqgssvlvslEdGwdvtaqvsslaqllldpyYRtle

GFQSLIQKEWVMGGHCFLDRCNHLRQNDK-EEVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQKDT-NMGREGQDTQSKP
||. |..|||.  || | .|.|.  .. .    |||| |||||.|. .|.| |||| . ||..|.       | ||...| ...   .. .| . .. . 
GFkvLveKEWLafGHrFtkrsnqtlsaqssgfaPvFlqFLDcvhqvsrqfPlafefndfylkflayhsvsnrfrtfllDseyerlesgllyeekaekrak

LNLLTVWDWSVQFEPK
    .|||.  . ...
kagksvwdyidrqhkr
Myotub-related Myotubularin-like phosphatase domain 321-501 1.4e-53 174.9 Pfam-A 169-351 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 321-501 1.4e-53 174.9 In-house 169-351 (353) alignment
subfamily_MTMR3_pd Subfamily MTMR3 321-504 8.2e-39 126.6 In-house 209-391 (442) alignment 
Range on Protein: 321-504
Range on HMM: 209-391/442.0
FLSLQEIQTAYSKFKQLFLIDNSTefwDTDIKWFSLLESSSWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISSLVQLMMDPHCRTRIGFQ
||.|  | .  . |..|  . ...     ...|.| ||. .||  .   ||.|....| .. ..  ||.   .  |    | .| .|..||. ||  ||.
flglanihavrksfnslrallsqs...pdesnwlsalektkWlqnlsvllkaavkvveavdkegrpvlvhCsdGWdrttqivalakllldpyyrtleGfk

SLIQKEWVMGGHCFLDRCNHLRQND--KEEVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQKDTNM
 |...||.  || | ||| |  . |  .|  |||| .||.| || .|.| .|||.|..|  |    |  .| ||..|| ... .. 
vlvereWldfGhkfadrcghgenvddanercPvflqwldavhqlqrqfPtsfefneaflvklvqhtysclfGtflansekereeek
subfamily_MTMR9_pd Subfamily MTMR9 339-504 6.7e-46 149.1 In-house 172-340 (393) alignment 
Range on Protein: 339-504
Range on HMM: 172-340/393.0
LIDNSTEFWDTDIKWFSLLESSSWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISSLVQLMMDPHCRTRIGFQSLIQKEWVMGGHCFLDRC
|..  ..   .  |..| ||.| ||. ..  |. |  ...|.. ... |.. .|.  |  . ..||.||..||..||  ||..||..||. .|| |  |.
lleacsdaglstdkflsrleksgwlsqvadlleaalvvaqcldeegapvvvhgeeGlDatlqvtsLaqlildpdaRtvrgfealiereWiqaGHPFasRa

NHLRQND---KEEVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQKDTNM
...  ..   |.. ||||||||||.|...|.| .||| |..|..|    |   |.||  .. ...... 
skvaaketkkklsgpvfllFLDcvyqilsqfpasFEFneelLillfehsyssqfgtflcdneaerkelk
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 348-498 1.3e-29 95.2 In-house 198-347 (405) alignment 
Range on Protein: 348-498
Range on HMM: 198-347/405.0
DTDIKWFSLLESSSWLDIIRRCLKKAIEITECMEAQNmNVLLLEENASDLCCLISSLVQLMMDPHCRTRIGFQSLIQKEWVMGGHCFLDRCNHLRQNDKE
 ||....  .| . |.  |.  |. |   .| .   |  .|.   .  |    |.|| |...||. ||  ||| ||.|||.  || |  |  ||  |..|
stdmrfwgyieetgwishiksileaatfsaelilkgn.silvhcsdgwdrtpqitsltqilldpyyrtivgfqvliekewlsfghkfslrlghlpgneee

EVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPH
  |.|  ||||..||. | |  |||| . | ..|| ..   . ||. |  .
rspifqqfldccfqllsqfpllfeftpslllfisdnihsckygtflnncek
subfamily_MTMR1_pd Subfamily MTMR1 349-502 6.9e-45 146.0 In-house 177-332 (389) alignment 
Range on Protein: 349-502
Range on HMM: 177-332/389.0
TDIKWFSLLESSSWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISSLVQLMMDPHCRTRIGFQSLIQKEWVMGGHCFLDRCNH--LRQNDK
 | ||.| |||. ||. |.  |. |..| |..| ....||.  ..  |    . || .|..|.. ||  ||. ||.|||.. || | .|  |    ..|.
ddkkwlsalestkWlehiklilagavkivekvetektsvlvhcsdGWDRtaqltsLamlllDsyyRtieGfevliekeWlsfGHkfkeRlghgdknssda

EEVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQKDT
|. |||| |.|||||| .|.| ||||.|..| .| | ||  .| || ||| ...  
ersPvFlqfiDcvwqltrqfptAFefneefLitlldhlysclfGtflfnsekervk
subfamily_pats1_pd Subfamily pats1 450-499 1.7e-09 28.6 In-house 554-603 (691) alignment 
Range on Protein: 450-499
Range on HMM: 554-603/691.0
PVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQ
|.|. ||| |||| .. |  ||| | .| .| .  .   | .|...   .
PifvqfldlvwqlqkefPfhfefneslllllvkesfssrfGnflyseakr
3-PAP Myotubularin-associated protein 579-706 2.3e-39 124.9 Pfam-A 1-136 (142) alignment 
Range on Protein: 579-706
Range on HMM: 1-136/142.0
HQRQL--------SLPLTQSKSSPKRGFFREETDHLIKNLLGKRISKLINSSDELQDNFREFYDSWHSKSTDYHGLLLPHIEGPEIKVWAQRYLRWIPEA
|.|.|        ||| ....|....|.. |..|.|...|| ...|.. .||.. ............|...|.|.||||.  |.....| |.||||||||
hkrslryygsfarslpwkhrrsvavagesseapdllllkllisllsdcsvsspspataseqlsktassvPadlhqlLlpqqlgldlslWsqcylRwiPea

QILGGGQVATLSKLLEMMEEVQSLQEKIDERHHSQQ
.| |||||.. .||.|..||...||.....|..|. 
eikgggqvqvdlklselleeiaklqrlleqrdmsdl