Gene MTMR9 in Homo sapiens

Synonym: C8orf9, LIP-STYX, MTMR8, MTMR9

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR9
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP060_AA protein Get Run
HsapP060_AA_122-505 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Myotub-related Myotubularin-like phosphatase domain 108-447 2.7e-135 443.7 Pfam-A 2-352 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 108-447 2.7e-135 443.7 In-house 2-352 (353) alignment
subfamily_MTMR6_pd Subfamily MTMR6 109-502 2.2e-115 378.1 In-house 2-396 (397) alignment 
Range on Protein: 109-502
Range on HMM: 2-396/397.0
YPFFYRPMFEV--IEDGWHSFLPEQEFELYSSATSEWRLSYVNKEFAVCPSYPPIVTVPKSIDDEALRKVATFRHGGRFPVLSYYHKKNGMVIMRSGQPL
| | |.|. .    ..||. .  ..|..    . ..| |. .||.. .| .||  . ||||.. | |   . ||  ||.|||||.||.|   | |. |||
yafsykpkkdkeekvsGwklldlkaeytrmgvpnekwtltdlnkdyelcdtyprelyvPksatkevlvgsskfrskgrlPvlsylhkeneaaicrcsqpl

TGTNGrRCKEDEKLINATLRAGK---RGYIIDTRSLNVAQQTRAKGGGFEQEAHYPQWRRIHKSIERYHILQESLIKLVEACNDQTHNMDRWLSKLEASN
.| .  ||.|||||..|  .|       |..|||    |   .|.| |.|.|..|   .    .||  |...||| ||.|... .....  .|| ||.|.
sgfsa.rcledeklleairkanpnsellyvvdtrpklnalankaagkGyenednysnikfqfvgienihvmreslqkllevvelksksvseflsglessg

WLTHIKEILTTACLAAQCIDREGASILIHGTEGTDSTLQVTSLAQIILEPRSRTIRGFEALIEREWLQAGHPFQQRCAQSaycNTKQKWEAPVFLLFLDC
|| ||| .| .... |. . .||||.|.| ..| | | ||.|||...|.|  |||.||  |||.|||  || |..|| .    ....|  .|.|. ||.|
wlkhikavldasifiakavaeegasvlvhcsdGwdrtaqvcslasllldpyyrtikGflvliekewlsfGhkfsercGll...dedskevsPiftqflec

VWQILRQFPCSFEFNENFLIMLFEHAYASQFGTFLGNNESERCKLKLQQKTMSLWSWVNQpsELSKFTNPLFEANNL--VIWPSVAPQSLPLWEGIFLRW
|||.|.|||..|||||.||. | .| |..||||||||.| .| .|||...|.|||... .  . ....|||..|..   |..|..||..| || ... |.
vwqlleqfpkafefnerfllelhdhvyscqfGtflgncekdrrdlklkertkslwaylle..rkddylnplykaetekevlkpdtapaalklwralynrf

N
.
d
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 109-502 8.3e-112 366.3 In-house 1-403 (404) alignment 
Range on Protein: 109-502
Range on HMM: 1-403/404.0
YPFFYRPMFEVIEDGWHSFLPEQEFELYSSATS-EWRLSYVNKEFAVCPSYPPIVTVPKSIDDEALRKVATFRHGGRFPVLSYYHKKNGMVIMRSGQPLT
. | |.. . |.||||  . .|.|..  .  .. |||.| .|... .|..|| .. ||.|| || | |||.||. ||.||||. |.... .|.|| ||| 
fafsysekksvledgwliydaeeEykRlgikseseWriskinsdyelcetYPkllvvPesisDeelkkvasfRskgRiPvlswrhrsknstitRssqplv

GTNGRRCKEDEKLINATLR---AGKRGYIIDTRSLNVAQQTRAKGGGFEQEAHYPQWRRIHKSIERYHILQESLIKLVEACNDQTHNMDRWLSKLEASNW
| ...|..|||||||.      ...  ||.|.|.   | ...||| |.|.  .| .     ..||  | |.||| || .|.|. ... . |||.|| |.|
GltksrseedEklinsirkaktqletlyildarpkanavansakgagyedisryenceieflnienihelreslkklkkavnsiiekeknwlselessrW

LTHIKEILTTACLAAQCIDREGASILIHGTEGTDSTLQVTSLAQIILEPRSRTIRGFEALIEREWLQAGHPFQQRCAQsaYCNTKQKWEAPVFLLFLDCV
| |||..|...  ... |. |. |.|.|  .| | | |..||.|..|.|  |||.||. |||.|||. || |.||..|    ..... ..|.|| |.|||
ldhiklllegskriveliekekssvlvhcsdgwDrtsqlsslsqllldpyyrtiegFivliekewlsfGhkfaqRigq..ttekssdersPiflqFidcv

WQILRQFPCSFEFNENFLIMLFEHAYASQFGTFLGNNESERCKLKLQQKTMSLWSWVNQPSelSKFTNPLFEAN----NLVIWPSV-----APQSLPLWE
.|...||| ||||||.||| . .. |...||||| ..| || . .|...|.|||. ...    |.. |||. ..    .  |  |       .. . ||.
yqltkqfptsFeFnekflikildalyscrfgtFLydsekeRqqnnlaketvslWalleank..seylnplyilekkeqkenitssessssadikliklWs

GIFLRWN
  .|||.
eyylrwr
subfamily_MTMR9_pd Subfamily MTMR9 110-502 1.8e-198 651.4 In-house 1-393 (393) alignment 
Range on Protein: 110-502
Range on HMM: 1-393/393.0
PFFYRPMFEVIEDGWHSFLPEQEFELYSSATSEWRLSYVNKEFAVCPSYPPIVTVPKSIDDEALRKVATFRHGGRFPVLSYYHKKNGMVIMRSGQPLTGT
|||||......|||...| .|.||. ..||..|||.|.|||.|.||.|||. |.|||.||||.|...|.||.|||||||||.||....|..||.|||.|.
pffyrsvatiledgysafdrenefaklisasdewRissvNknfkvcasypesvivPkaiddeelkasaafreggrfPvLsylhketkavllrssqplcgs

NGRRCKEDEKLINATLRAGKRGYIIDTRSLNVAQQTRAKGGGFEQEAHYPQWRRIHKSIERYHILQESLIKLVEACNDQTHNMDRWLSKLEASNWLTHIK
.|.||||||||.|..|...|.|.|.|||| ..|...|.||||.|.|..|.||.....|.|.....|.||.||.|||.|.....|..||.||.|.||....
sgkrckedekllnlvlkklkkGlivdtrsksaaenarskgggietevkysqwkkasrslesvasiqdslaklleacsdaglstdkflsrleksgwlsqva

EILTTACLAAQCIDREGASILIHGTEGTDSTLQVTSLAQIILEPRSRTIRGFEALIEREWLQAGHPFQQRCAQSAYCNTKQKWEAPVFLLFLDCVWQILR
..|..|. .|||.|.|||....||.||.|.|||||||||.||.|. ||.|||||||||||.||||||..|....|...||.|...||||||||||.|||.
dlleaalvvaqcldeegapvvvhgeeGlDatlqvtsLaqlildpdaRtvrgfealiereWiqaGHPFasRaskvaaketkkklsgpvfllFLDcvyqils

QFPCSFEFNENFLIMLFEHAYASQFGTFLGNNESERCKLKLQQKTMSLWSWVNQPSELSKFTNPLFEANNLVIWPSVAPQSLPLWEGIFLRWN
|||.||||||..||.||||.|.|||||||..||.||..|||..||.||||.||.|..|..|.|||.|||. ||||||||||| ||....|||.
qfpasFEFneelLillfehsyssqfgtflcdneaerkelklkkktvslwsyvnrpeklkqflnplyeanaeviwpsvapqslelWselylrwq
0040695 (Phosphotyrosine protein) phosphatases II 119-503 4.1e-137 450.8 In-house 3-387 (388) alignment 
Range on Protein: 119-503
Range on HMM: 3-387/388.0
VIEDGWHSFLPEQEFELYSSATSEWRLSYVNKEFAVCPSYPPIVTVPKSIDDEALRKVATFRHGGRFPVLSYYHKKNGMVIMRSGQPLTGTNGRRCKEDE
..|.||. . ...|.. .   ...||.|.||... .|||||... |||||.|| |..||.||..||.|||||.|..||.|..||.|||.|....|..|||
lleegwslydilrelkrlglgldlwrisivNenyelcpsYPallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplvglllsrslede

KLINATLR---AGKRGYIIDTRSLNVAQQTRAKGGGFEQEAHYPQWRRIHKSIERYHILQESLIKLVEACnDQTHNMDRWLSKLEASNWLTHIKEILTTA
||..| |.     ....|.|.|.   |...||.|||.|.| .||... |...|...| ..|||.||..|| .........||.|| |.|| .|| || .|
klleailkllpnlskllivdlrpklnalanralgggvenedaypnaeliflnipnihvvreslqklldac.lnvpdslnllslleesgwldliklilela

CLAAQCIDREGASILIHGTEGTDSTLQVTSLAQIILEPRSRTIRGFEALIEREWLQAGHPFQQRCAQsAYCNTKQKWEAPVFLLFLDCVWQILRQFPCSF
.|.....|... |.|.|...|.|.| |..||||..| |  ||..||  |||.|||..||.|..|. . .. ....| ..||||||||||||.|||||..|
vlivklldlgnssvlvhcsdgwdrtsqlssLaqllldPyYRTleGFqvLiekeWlsfghkfadRlgh.leseidskefsPvFllFLdcvwqLlrqfPtaF

EFNENFLIMLFEHAYASQFGTFLGNNESERCKLKLQQKTMSLWSWVNQPSELskFTNPLFEANNL-VIWPSVAPQSLPLWEGIFLRWNR
||||..|. |..|.|...|||||.|.| || .|.....|.||||.......   |.|||.. . | |..||. ...| || . .|||..
eFnerlLlfLadhlyscrfgtFlfnsekerlelsvsertlslwsyllsrkse..flnplYdpsslevllpslsvldlllWleyylrwlp
subfamily_MTMR1_pd Subfamily MTMR1 121-502 5.9e-121 396.4 In-house 4-387 (389) alignment 
Range on Protein: 121-502
Range on HMM: 4-387/389.0
EDGWHSFLPEQEFELYSSATS-EWRLSYVNKEFAVCPSYPPIVTVPKSIDDEALRKVATFRHGGRFPVLSYYHKKNGMVIMRSGQPLTGTNGRRCKEDEK
||||. . ||.|.|     ..  || . .||....|..||....|||...|| |.|||.||  ||.||||...|.|. ||.|. |||.|..|.|.|||||
edGWkvydpeaelerlgllneklWritklnkkyelcdtYpavlvvpkvvsdedlkkvaafrskgRlPvlswlnkenqavilrasqplvGlsgkrskedek

LINATLRAGKRG---YIIDTRSLNVAQQTRAKGGGFEQEAHYPQWRRIHKSIERYHILQESLIKLVEACNDQTHNmDRWLSKLEASNWLTHIKEILTTAC
...| | | ..    .|.| ||   |.. .|||.| |.|. | . . |.  |. .|...||| || |..  .... ..|||.||...|| ||| ||..| 
ylqaileanaqsekllildarssvnavankakgkgyeseeaYknaelifldihnihvvReslkklkelvlpnvdd.kkwlsalestkWlehiklilagav

LAAQCIDREGASILIHGTEGTDSTLQVTSLAQIILEPRSRTIRGFEALIEREWLQAGHPFQQRCAQsAYCNTKQKWEAPVFLLFLDCVWQILRQFPCSFE
  ......| .|.|.| ..| | | |.||||...|..  |||.||| |||.|||. ||.|..| .. .  |.... ..|||| |.|||||. ||||. ||
kivekvetektsvlvhcsdGWDRtaqltsLamlllDsyyRtieGfevliekeWlsfGHkfkeRlgh.gdknssdaersPvFlqfiDcvwqltrqfptAFe

FNENFLIMLFEHAYASQFGTFLGNNESERCKLKLQQKTMSLWSWVNqpSELSKFTNPLFEAN--NLVIWPSVAPQSLPLWEGIFLRWN
|||.|||.| .| |.. ||||| |.|.|| | |...||.||||.||  |. ..|||||.. .  . |. | .. ..| ||.  .||||
fneefLitlldhlysclfGtflfnsekervkekvkektvslwsyvn..sskeeftnplyaeelekkvlypkaslrrlelWkeyylrwn
subfamily_MTMR10_pd Subfamily MTMR10 124-467 1.1e-61 200.7 In-house 7-324 (380) alignment 
Range on Protein: 124-467
Range on HMM: 7-324/380.0
WHSFLPEQEFELYSSATSEWRLSYVNKEFAVCPSYPPIVTVPKSIDDEALRKVATFRHGGRFPVLSYYHKKNGMVIMRSGQpltGTNGRRCKEDEKLINA
| | | . | .  . .. ... . .|. ||.....|. . ||.|..|. ....    . .|||.... | |   ... |..   ...    ||.|. .. 
wrselerleekekktvsdaivvllknelfaaaqtlPqyfvvpnslsdsdverlsrhykesRfplwvwshakgaallrlsal...qeaesadkekeekmle

TLRAGKRGYiidtrslnvaqqtrakgggfeqeahYPQWRRIHKSIERYHILQESLIKLVEACN-----DQTHNMDRWLSKLEASNWLTHIKEILTTACLA
..|... .                            . . ......  . .|..  || | |      .  .  |.|||.|| ..||  .. .| ||  |
lvrkchpan.........................dvklvdlsdelpsiqdvqkaylklreLcvidtseefvtlddkwlssLektrWLayvrlclstasda

AQCIDREGASILIHGTEGTDSTLQVTSLAQIILEPRSRTIRGFEALIEREWLQAGHPFQQRCAQsayCNTKQKWEAPVFLLFLDCVWQILRQFPCSFEFN
.... ... |...   || |  . | ||||..|.|  |||.||. ||..||  |||||..|. .   .  ..| |.||||||||||.| |.||| .|||.
vktvvekkrsvilqesegrDlscvvaSLaqlmldphyrtisGfqsliqkewvaaghpfldrlgh...ikpseksespvfllFldcvdqlleqfpseFeFt

ENFLIMLFEHAYASQFGTFLGNNESERCKLKLQQKTMSLWSWVNQPSEL
| |||.|. . ... |.||| |.|..| | . ... . .  .  . ..|
etfLialwdsshsgifltflfnseeqrlkavvsssplliakselkendl
subfamily_MTMR5_pd Subfamily MTMR5 136-205 5e-19 60.5 In-house 24-93 (483) alignment 
Range on Protein: 136-205
Range on HMM: 24-93/483.0
YSSATSEWRLSYVNKEFAVCPSYPPIVTVPKSIDDEALRKVATFRHGGRFPVLSYYHKKNGMVIMRSGQP
 .|.. ..|.| |||...|| ||| .. ||....|.....||   . .|.||  . |..|. ...|||..
gaskrgkfrisevNkkytvcrsYPalivvPsevsddsiarvakcfrqnRlPvvtWrhernkalLiRsggf
subfamily_pats1_pd Subfamily pats1 137-201 3.6e-06 17.6 In-house 20-82 (691) alignment 
Range on Protein: 137-201
Range on HMM: 20-82/691.0
SSATSEWRLSYVNkEFAVCPSYPPIVTVPKSIDDEALRKVATFRHgGRFPVLSYYHKKNGMVIMR
 .   .||   .  .  ..  ||. . |||.. || |   .  |.  ..||||. ...|  ...|
ldldkdwrvvefl.srdlseiyPkrilvPklvsdellvsyvrkrs.skiPvlswsnqnnksslfr
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 138-501 4.2e-75 245.0 In-house 37-404 (405) alignment 
Range on Protein: 138-501
Range on HMM: 37-404/405.0
SATSEWRLSYVNKEFAVCPSYPPIVTVPKSIDDEALRKVATFRHGGRFPVLSYYHKKNGMVIMRSGQPLTGTNGRRCKEDEKLIN-ATLRA-GKRGYIID
|... |... .|||. .| ||.  . | .   |  | |. .||  || | ||.   .    | |  ||| | .  || |||      .| |  |  |.||
ssncywkvtsinkeykmcssyssslvvlskaldkdlekifsfrskgripslswkdpssnasisrcsqplvgierarcpedelycsslalsapsktlylid

TRSLNVAQQTRAKGGGFEQEAHYPQWRRIHKSIERYHILQESLIKLVEACNDQTH------NMD-RWLSKLEASNWLTHIKEILTTACLAAQCIDrEGAS
.|    |    |.| |||.   ||. . .   |   |... || ||| | .  ..        | |.   .| . |..||| || .| ..|. |   | |
arpklnaiantangagfenihnypncklvfmnipnihvirksleklvlamkssardkdhtestdmrfwgyieetgwishiksileaatfsaelil.kgns

ILIHGTEGTDSTLQVTSLAQIILEPRSRTIRGFEALIEREWLQAGHPFQQRCAQSAycnTKQKWEAPVFLLFLDCVWQILRQFPCSFEFNENFLIMLFEH
||.| ..| | | |.|||.||.|.|  ||| ||. |||.|||  || |  |  .      ...  .|.|  ||||..|.| |||  |||  ..|... . 
ilvhcsdgwdrtpqitsltqilldpyyrtivgfqvliekewlsfghkfslrlghlp...gneeerspifqqfldccfqllsqfpllfeftpslllfisdn

AYASQFGTFLGNNESERCKLKLQQKTMSLWSWVNQpsELSKFTNPLFEANNL-VIWPSVAPQSLPLWEGIFLRW
 .. ..|||| | | .| . ... ||.|.|| ||   .. || || .. ...  | | .  . | ||   ..| 
ihsckygtflnncekdrvqdqvktktisiwsevnl..nvnkflnpyynpqdiqsikpklysrclelwkacymrv
subfamily_MTMR3_pd Subfamily MTMR3 139-228 6.9e-28 90.6 In-house 40-129 (442) alignment 
Range on Protein: 139-228
Range on HMM: 40-129/442.0
ATSEWRLSYVNKEFAVCPSYPPIVTVPKSIDDEALRKVATFRHGGRFPVLSYYHKKNGMVIMRSGQPLTGTNGRRCKEDEKLINATLRAG
 ...||.| ||..| .|.|||  . |||||.|..|.|||.||  .|.|.. . ||||| |..|..||  |  | |..|||||..|  .| 
lkeawrisdvnsdfklCssyPkklivPksitdddlkkvasfrslkrlPavvwrhkkngavlarcsqPevgwlgWrnaedekllkaiakac
subfamily_MTMR3_pd Subfamily MTMR3 232-499 7.9e-78 255.2 In-house 176-440 (442) alignment 
Range on Protein: 232-499
Range on HMM: 176-440/442.0
YIIDTRSLNVAQQTRAKGGGFEQEAHYPQWRRIHKSIERYHILQESLIKLVEACNdQTHNMDRWLSKLEASNWLTHIKEILTTACLAAQCIDREGASILI
 |.| ||   |   ||||||.|.| .||.   .....   | ...|. .| . .. |...  .|||.||. .|| .. ..|..|   .. .|.|| ..|.
livdarsytaafanrakgGGceleeyypncevvflglanihavrksfnslralls.qspdesnwlsalektkWlqnlsvllkaavkvveavdkegrpvlv

HGTEGTDSTLQVTSLAQIILEPRSRTIRGFEALIEREWLQAGHPFQQRCAQSAYCNTKqKWEAPVFLLFLDCVWQILRQFPCSFEFNENFLIMLFEHAYA
| ..| | | |...||...|.|  ||..||..|.|||||. || |. ||..    ... .  .|||| .||.| |. ||||.|||||| ||. | .|.|.
hCsdGWdrttqivalakllldpyyrtleGfkvlvereWldfGhkfadrcghgenvdda.nercPvflqwldavhqlqrqfPtsfefneaflvklvqhtys

SQFGTFLGNNESERCKLKLQQKTMSLWSWVNQPSelSKFTNPLFEA-NNLVIWPSVAPQSLPLWEGIFL
. |||||.|.| || . |....|.|.||....     ...| |..  .. |..|.|  ..| ||. ..|
clfGtflansekereeekvkertlsvWsllrake..keyrnllykekteavllpavsvrelklwsevyl
subfamily_MTMR5_pd Subfamily MTMR5 264-495 1.4e-52 171.1 In-house 231-476 (483) alignment 
Range on Protein: 264-495
Range on HMM: 231-476/483.0
IHKSIERYHILQESLIKLVEACNDQTH----NMDRWLSKLEASNWLTHIKEILTTACLAAQCIDREGASILIHGTEGTDSTLQVTSLAQIILEPRSRTIR
|   .     .. |. ||. ||  .|.    ..  .|...|.|.||. |...|  .  ... .| .|.|.|.   .| | | ||.||||..|.|  ||. 
ipvelveirqvkasfkkllraClpstaveeaesqsFlksvedseWlqqissllqlsgavvdlldlqgssvlvslEdGwdvtaqvsslaqllldpyYRtle

GFEALIEREWLQAGHPFQQRCAQSAYCNTKqkWEAPVFLLFLDCVWQILRQFPCSFEFNENFLIMLFEHAYASQFGTFLGNNESERCKLKL---------
||..|.|.|||  || |..|..|   ...     ||||| |||||.|. |||| .||||. .| .|  |  . .| ||| . | || .  |         
GFkvLveKEWLafGHrFtkrsnqtlsaqss..gfaPvFlqFLDcvhqvsrqfPlafefndfylkflayhsvsnrfrtfllDseyerlesgllyeekaekr

-QQKTMSLWSWVNQPSELS-KFTNPLFEA-NNLVIWPSVAPQSLPLWE
 .. ..|.| .... .. |  | | |..  .. |. ||.   || .|.
akkagksvwdyidrqhkrspifynflyspdesevlrPssnvsslkvWd
subfamily_pats1_pd Subfamily pats1 275-382 5e-20 63.4 In-house 350-459 (691) alignment 
Range on Protein: 275-382
Range on HMM: 350-459/691.0
QESLIKLVEACNDQTHNMDRWlSKLEASNWLTHIKEILTTACLAAQCIDrEGASILIHG-TEGTDSTLQV---TSLAQIILEPRSRTIRGFEALIEREWL
.|   .|...  .   ..| | ...| | |.  .| .| .|   .. .| || |.|..  ... . .|..   .||||....|  ||. ||  |||.|||
eerffdllqsilsldgsddew.keieeskwvdsvkllleaavkvsnlld.eGssvllknsidsPlieldlasisslaqvlsdPfyrtldGfkvliekewl

QAGHPFQQRCAQ
. |.||....  
syGfPfskinyh
subfamily_pats1_pd Subfamily pats1 394-476 1e-22 72.3 In-house 553-633 (691) alignment 
Range on Protein: 394-476
Range on HMM: 553-633/691.0
APVFLLFLDCVWQILRQFPCSFEFNENFLIMLFEHAYASQFGTFLGNNESERCKLKLQQKTMSLWSWVNQpsELSKFTNPLFE
.|.|. ||| |||. ..||  ||||| .|..| .....|.||.|| ..  ..   |. ... |.||..||  . |.|.| |. 
sPifvqfldlvwqlqkefPfhfefneslllllvkesfssrfGnflyseakrdserkvlkrsksiwsfinq..nksrfinllyk