Gene PTPRB in Homo sapiens

Synonym: HPTP-BETA, HPTPB, PTPB, R-PTP-BETA, VEPTP, PTPRB

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRB
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP090_AA protein Get Run
HsapP090_AA_1903-2183 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Ricin_B_lectin Ricin-type beta-trefoil lectin domain 23-90 3.5e-09 23.2 Pfam-A 48-119 (124) alignment 
Range on Protein: 23-90
Range on HMM: 48-119/124.0
IVHVQKQQ-CL-F----KNEKVVVGSCNRTIQNQQWMWTEDEKLLHVKSALCLAISNSSrgPSRSAILDRCSQA
| . .|.. ||      .. .|.. |||   .||.|  .|. .. . || ||| ....|   .   || .|.. 
irsnkkselCLdvsgskegsnvqlascnsgssnqrWtydengtivnrksglcLdvkgas..ngtkvilqecngs
fn3 Fibronectin type III domain 254-318 2.8e-08 27.0 Pfam-A 11-78 (85) alignment 
Range on Protein: 254-318
Range on HMM: 11-78/85.0
ASSHSVSIQWRIL----GSPCNFSLIYSSDTLGAaLCPTFRIDNTTYGCNLQDLQAGTIYNFRIISLDE
 .|.|....|       |   .... |.... |   . .|....||. ..|..|..|| |.||. ....
vtstsltlsWsppkdgggpitgYeveyrekggge.ewkeftvprtttsvtltgLkpgteYefrVqavng
fn3 Fibronectin type III domain 334-407 2.4e-15 49.6 Pfam-A 4-79 (85) alignment 
Range on Protein: 334-407
Range on HMM: 4-79/85.0
FGVSKEKTTSTSLHVWWTPS---SGKVTSYEVQLFDENNQKiqgVQIQESTSWNE--YTFFNLTAGSKYNIAITAVSGG
 ..| . .|||||.. |.|.   .|..|.|||.. ......   .  . ......  .|. .|..|..|.. ..||.|.
enlsvsevtstsltlsWsppkdgggpitgYeveyrekggge...ewkeftvprtttsvtltgLkpgteYefrVqavnga
fn3 Fibronectin type III domain 425-490 2.7e-06 20.6 Pfam-A 4-75 (85) alignment 
Range on Protein: 425-490
Range on HMM: 4-75/85.0
KDIGIST-KANSLLISWSHG---SGNVERYRLMLMDK-GIL-VHGGVVDKHATSYAFHGLTPGYLYNLTVMT
... .|   ..|| .|||.    .|....|.. . .| |    .   |....||. ..||.||  |...| .
enlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqa
fn3 Fibronectin type III domain 510-582 5.4e-12 38.9 Pfam-A 3-79 (85) alignment 
Range on Protein: 510-582
Range on HMM: 3-79/85.0
VSNLKVTNDgSLTSLKVKWQRP---PGNVDSYNITLSHKGTIK-ESRVLAPWIT-ETHFKELVPGRLYQVTVSCVSGE
..||.|..  . ||| ..|. |    |....|......||. . . .. .|. | . ....| ||. |...|  |.|.
Penlsvsev.tstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavnga
fn3 Fibronectin type III domain 597-672 7.6e-10 32.0 Pfam-A 2-79 (85) alignment 
Range on Protein: 597-672
Range on HMM: 2-79/85.0
KVANLEANNNgRMRSLVVSWSPP---AGDWEQYRILLFNDSVV--LLNITVGKEETqyVMDDTGLVPGRQYEVEVIVESGN
.. || . .. . .||..|||||    |... |.. . ...      ..|| . .|   .  ||| ||..||..|   .|.
aPenlsvsev.tstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt..svtltgLkpgteYefrVqavnga
fn3 Fibronectin type III domain 687-759 2.1e-11 37.0 Pfam-A 2-79 (85) alignment 
Range on Protein: 687-759
Range on HMM: 2-79/85.0
AVLQLRVKHANETSLSIMWQTP---VAEWEKYIISLADRDLL--LIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGD
|. .|.|.  ..|||.. |. |    .....| . ... .      ...........|.|.| ||..|  .|....|.
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavnga
fn3 Fibronectin type III domain 774-847 1.1e-08 28.3 Pfam-A 2-79 (85) alignment 
Range on Protein: 774-847
Range on HMM: 2-79/85.0
QVTDLHVANQgMTSSLFTNWTQA---QGDVEFYQVLLIHENVV--IKNESISSETSRYSFHSLKSGSLYSVVVTTVSGG
....|.| ..  ..||  .|.     .|... |.| . ...     |. .... |... .. || |. |.. |..|.|.
aPenlsvsev.tstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavnga
fn3 Fibronectin type III domain 862-938 1.4e-11 37.5 Pfam-A 1-81 (85) alignment 
Range on Protein: 862-938
Range on HMM: 1-81/85.0
SSVSGVTVNNSgRNDYLSVSWLLA---PGDVDNYEVTLSHDGKV--VQSLVIAKSVRECSFSSLTPGRLYTVTITTRSGKYE
|......| .  ....|..||       |....|||.....|.    ..  . .. ... .. |.||. |........|..|
saPenlsvsev.tstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngage
fn3 Fibronectin type III domain 951-1025 1.2e-13 44.2 Pfam-A 2-80 (85) alignment 
Range on Protein: 951-1025
Range on HMM: 2-80/85.0
KVQGVSVSNSaRSDYLRVSWVHA---TGDFDHYEVTIKNKNNF--IQTKSIPKSENECVFVQLVPGRLYSVTVTTKSGQY
.....|||.  .|..|..|| .     |....|||. ..|..    .....|........ .| ||. |...|.. .|..
aPenlsvsev.tstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngag
fn3 Fibronectin type III domain 1039-1112 4.3e-11 36.0 Pfam-A 2-79 (85) alignment 
Range on Protein: 1039-1112
Range on HMM: 2-79/85.0
PVKDLTLRNRSTEDLHVTWSGA---NGDVDQYEIQLLFN-DMKVFPPFHLVNTATEYRFTSLTPGRQYKILVLTISGD
....|.......  |...||     .|... ||...    ....   |.. .|.|.. .| |.||..|.. | ...|.
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavnga
fn3 Fibronectin type III domain 1126-1200 5.8e-12 38.8 Pfam-A 1-79 (85) alignment 
Range on Protein: 1126-1200
Range on HMM: 1-79/85.0
SAVKNIHISPNgATDSLTVNWTPG---GGDVDSYTVSAFRH-SQK-VDSQTIPKHVFEHTFHRLEAGEQYQIMIASVSGS
||..|...|..  ..|||..|.|    ||....|.|      ...   ..|.|..  ..|.. |..| .|.. ...|.| 
saPenlsvsev.tstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavnga
fn3 Fibronectin type III domain 1216-1290 4.6e-11 35.9 Pfam-A 3-80 (85) alignment 
Range on Protein: 1216-1290
Range on HMM: 3-80/85.0
VQGVIADNAySSYSLIVSWQKA---AGVAERYDILLLTENGIL-LRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGL
.... ...  .| || .||..     |  ..|.. . ...|    .. . |.||.......|.||..|.... .|.|. 
Penlsvsev.tstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngag
fn3 Fibronectin type III domain 1305-1378 6.7e-10 32.2 Pfam-A 2-79 (85) alignment 
Range on Protein: 1305-1378
Range on HMM: 2-79/85.0
AVTDLRITENSTRHLSFRWTAS---EGELSWYNIFLYNPDGNLQERAQVDPLVQ-SFSFQNLLQGRMYKMVIVTHSGE
|...|...|.... |...|...   .|... |.. . . .|. ... .  |  . |. ...|  |. |.. . ...|.
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavnga
fn3 Fibronectin type III domain 1394-1466 9.3e-12 38.1 Pfam-A 3-79 (85) alignment 
Range on Protein: 1394-1466
Range on HMM: 3-79/85.0
VSHLRGSNRnTTDSLWFNWSPA---SGDFDFYELILYNPNGTKKENWKDKDLTE--WRFQGLVPGRKYVLWVVTHSGD
.. |. |.. |..|| ..|||    .|... ||. . . .|........ . |.    ..|| ||..|...| ...|.
Penlsvsev.tstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavnga
fn3 Fibronectin type III domain 1480-1560 2.2e-12 40.1 Pfam-A 1-83 (85) alignment 
Range on Protein: 1480-1560
Range on HMM: 1-83/85.0
SPPSLMSFADIANTSLAITWKGPP-DWTDYNDFELQWLPRDALTVFNPYNNRKSE-GRIVYGLRPGRSYQFNVKTVSGDSWKT
|.|. .|. .. .||| ..|. |. .  ..  .|... . .   . . ... ...   .. ||.||..|.|.|..|.|...  
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegp
fn3 Fibronectin type III domain 1575-1649 1.7e-13 43.7 Pfam-A 2-79 (85) alignment 
Range on Protein: 1575-1649
Range on HMM: 2-79/85.0
KIQNLHCRPQNSTAIACSWIPP---DSDFDGYSIECRKMDTQEVEFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSAG
...||......|| .  || ||   .....||..|.|.....|.. ...... .. ...  | |...| .... ....
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavnga
0050432 (Phosphotyrosine protein) phosphatases II 1893-2184 2.1e-103 341.1 In-house 18-301 (308) alignment 
Range on Protein: 1893-2184
Range on HMM: 18-301/308.0
GNRKTSCPIKINQFEGHFMKlqADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLsnvddDPCSDYINASYIPGN--NFRREY
.  ..| .. . ..  ...|  |....||..|.||| .|  . ....||||||. |||| .||||| .||||     |. ||||||||..|   ...|..
silvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkf

IVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPAD--QDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLdAHRLIRHFHYTVWPD
|.||||||.| .|||.|||||||. |||.|..||.||.||..||| .  ..||.||.. . .||| ||...|.|.....  .     | ..||||| |||
IatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg.esrtvthfhytnWpd

HGVPETTQSLIQFVRTVRDYInrsPGaGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRA
||||. ...|..|.. ||...   || ||.|||||||||||||||||| .|.||. .  ||...||. || .| .||||. ||..|.... . |. 
hgvPpspeilldflelvrksl...pg.gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
subfamily_PTPRA_pd Subfamily PTPRA 1893-2181 5.8e-87 286.6 In-house 7-294 (330) alignment 
Range on Protein: 1893-2181
Range on HMM: 7-294/330.0
GNRKtSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIV
||.|   |. ....|    . .|| | |. .|.. |     . ....|   ||. |||. |||||| .|| ||...  ..|||||||.| | . . ..| 
gnkk.yfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfia

TQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPaDQDSLYYGDLILQMLSESVLPEWTIREFKIC---GEEQLDAHRLIRHFHYTVWPDH
.|||.  | .|||.|.|||. . |||.|.  |. . ||  ||| |. .. ||.. ...  | || ..|.|.| .     . . ...||.| ||.| ||| 
aqGPkeetvedfwrmiweqksativmltelkerkeekcaqywP.deGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdv

GVPETTQSLIQFVRTVRDYINRSpgAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDV
||| ... ...... |.   ..|  ||| |||||||||||||||.|| .|... ..  ||....|. ||| | .||||. ||..... ... 
GvPfepiGmlkllkkvkklnqqs..agpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
0045450 (Phosphotyrosine protein) phosphatases II 1895-2181 8.5e-101 333.0 In-house 3-303 (307) alignment 
Range on Protein: 1895-2181
Range on HMM: 3-303/307.0
RKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGR--NQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDD-PCSDYINASYI--------PG
 ..|..|.. ... ....|..|....| ||.|.|..|    . ...|||||||. |||| .||||| ||||||..|.. . ||||||||.        .|
lplslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldg

NNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHY
 .. |..|.||||||.| .|||.|.|||.|. |||.|..||.||.||..||| ....|.||..   .|||..|...|.| ...   .. . .| ..||||
ydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhy

TVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDS---VDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRD
| |||||||.....|..|.. ||......|. ||..|||||||||||||||.. .|.||..      ||.. ||. || .| ..||.. ||..|......
tgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle

V
 
l
subfamily_PTPRB_pd Subfamily PTPRB 1896-2186 3.9e-136 447.8 In-house 2-289 (293) alignment 
Range on Protein: 1896-2186
Range on HMM: 2-289/293.0
KTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQG
|.| |||...||.|..|..|||.. .|.||||||.||..|....| |..|| ||||.||||||..||||....|.. ||||||.||||.| .||.|.|||
kkskpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqG

PLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGeeqLDAHRLIRHFHYTVWPDHGVPETT
|||.| ||||.||||.... |||.||.||||.|||..|||||... .|||. .....|..| .|.|||.||.     ...| .|..|.| ||||||||.|
PlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPekt

QSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARK
..|..||||||..|...  ..|.|||||||||||||||||||.||.....| |||.| |..|| .|...|||| ||...|||| |.|| ..
ktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkke
0039614 (Phosphotyrosine protein) phosphatases II 1896-2182 1.2e-99 328.8 In-house 9-289 (297) alignment 
Range on Protein: 1896-2182
Range on HMM: 9-289/297.0
KTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNqsCDIALLPENRGKNRYNNILPYDATRVKLSNVDD-DPCSDYINASYIPGNNF-RREYIVT
..|.||... .. ......|.|..|| .|.|||...  .  . |||||||. |||| .||||| .||||. .|. |. ||||||||..| ..  |..|.|
lesipiplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIat

QGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRvKCDHYWPADQDslYYGDLILQMLSESVLPEWTIREFKICGeeqLDAHRLIRHFHYTVWPDHGVPE
|||||.| .|||.|||||.|. |||.|..||.|| ||..||| ...  .|||.   .|.. .|. .|.|....      .  | ..||.|| |||||||.
qgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvpp

TTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVL
....|..|.. ||......|. ||..|||||||||||||||....|.||...  ||.. ||. || .| ..|||. ||..|...... |
slellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
subfamily_PTPRD_pd Subfamily PTPRD 1899-2185 1.1e-116 385.8 In-house 3-284 (564) alignment 
Range on Protein: 1899-2185
Range on HMM: 3-284/564.0
CPIKINQFEGHFMKLQADSNYLLSKEYEELKDVgRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLP
 ||...... |. ||.|.|.. ...||....   .. ... |  |.|. ||||.||..||..||.||.|. |. |||||||.| | . |..|| |||||.
kpipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

GTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQdSLYYGDLILQMLSESVLPEWTIREFKIcGEEQLDAHRLIRHFHYTVWPDHGVPETTQSL
 | .|||.||||||.. |||.|...|||.|||..|||... .  ||.|. .. .|  | . .||.||.  ... .  | .|.||.| ||||||||...||
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatsl

IQFVRTVRDYInrSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRAR
....|.||..   .|.|||.|||||||||||||||..| .|... ... ||||. |. || .| .|||||.||...|. . . | . 
Ldlirkvraln..epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacg
0051299 (Phosphotyrosine protein) phosphatases II 1899-2181 1.3e-105 348.3 In-house 3-285 (288) alignment 
Range on Protein: 1899-2181
Range on HMM: 3-285/288.0
CPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLP
 .|...... ...||.|.....| .|.||| ..  . .. .||||||. |||| .||||| .|||||..|... |||||||||.| |. |..|.||||||
teisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlp

GTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPAdQDSLYYGDLILQMLSESVLPEWTIREFKICGEE---QLDAHRLIRHFHYTVWPDHGVPETT
.| .|||.|||||||. |||.|..||.||.||..|||  ..||.|||.   .||| ||...|.|....   .   . . .| ..||||| |||||||...
ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

QSLIQFVRTVRDYINrsPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDV
..|..|.| ||....  .| ||.|||||||||||||||||| .|.||. .  ||...||. || .| .||||..||....... . 
ellldflrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1899-2184 1.4e-90 298.6 In-house 3-285 (319) alignment 
Range on Protein: 1899-2184
Range on HMM: 3-285/319.0
CPIKINQFEGHFMKLQADSNYLLSKEYEELKDvGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLP
 .|...... ....|.. .. || ||...||  . |.. | |  .||. ||||.|||.|| |||.||..|. . |||||||.| | . |...| ||.|| 
teievqeLkerlkalastgetllekefkllke.avndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPle

GTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQdSLYYGDLILQMLSESVLPEWTIREFKICGEE-QLDAhRLIRHFHYTVWPDHGVPETTQS
 | .|||.||||.... .||.|. |||..||. .|||  .    || ||.....|  | .. ||..|.     .... | . ||.|| ||||.|||...|
ntiedfWrmvWeeessivvmltklveklkvklkkywpeen.feeyGrlivtleeeeeledyiirklklnkkssevet.RevkhfqyteWpdhdvPekats

LIQFVRTVRDYInRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRA
|..... .|    . . .|| |||||||||||||||.|| .|...     .|..  |  ||. |  |||.. || .... ..... |
lldllkrirksr.ektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea
0043336 (Phosphotyrosine protein) phosphatases II 1900-2180 5.7e-98 323.0 In-house 1-275 (278) alignment 
Range on Protein: 1900-2180
Range on HMM: 1-275/278.0
PIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRnQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPG
||...... ....| .....||..|.||| ..    ...|||||||. |||| .||||| .|||||... |. ||||||||..| |. |..|.||||||.
pisvkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe

TKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPadQDSLYYGDLILQMLSESVLPEWTIREFKICGeEQLDAHRLIRHFHYTVWPDHGVPETTQSLI
| .|||.||||..|. |||.|..||.|||||..|||  ..||.|||.   .|.| .|. .|.| ...    . .  | ..|.||. ||||||||....|.
tvedFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtn.lgdgesrtvthyhylgwpdhgvpeslslll

QFVRTVRDYINrsPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRD
.|...||....  .  ||..||||||||||||||||...|.||..   ||.. ||..|| .| ..|||. ||..|......
dflkavreale..dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_Ptp69D_pd Subfamily Ptp69D 1900-2181 8.9e-84 276.2 In-house 3-285 (307) alignment 
Range on Protein: 1900-2181
Range on HMM: 3-285/307.0
PIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPG
.|.| . |  . . . |....| ||||.|.    ..|. ..   ||  ||||..| ..| |||||...  .  |||||||.| | . ....|. |.|. .
aiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPvea

TKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADqDSLYYGDLILQMLSESVLPEWTIREFKICGEE----QLDAHRLIRHFHYTVWPDHGVPETT
| .|||.|..||.|. |||...  || | ||..||| . |   |||.. .. ||.  ....|||...   .    .....| .  .||| |.|  |||..
tigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPeva

QSLIQFVRTVRDYINRSpgAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDV
..|..... ||.  . .   .| ||||||||||.|.|.||| .||||   |.|||.  |.||| .|  .||   |||.|.. . | 
rgllklieqvrelykln..rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldy
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1900-2184 5.9e-80 263.7 In-house 3-285 (305) alignment 
Range on Protein: 1900-2184
Range on HMM: 3-285/305.0
PIKINQFEGHFMKLQADSNYLLSKEYEELKDVgrNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPG
.| ..... . .. ...|.  | ..|..| .   ..|.|.    .|. |||...| ..|  |..|.. .... ||||||||. | . . .|||.||||. 
iialddlaayikearvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkn

TKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDS-LYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSL
| .|||....|  |..|||.|. || |. ||  |||  .     .|...... ||.  .....|..||. |.. .  | . ... | |||||||... ||
tvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsl

IQFVRTVRDYINRSPGaGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRA
..... |.   ... |  | .|||||||||||.|||.|  |..|   ..||... .. || .|. ||||  |||.||. . . . .
lslikrvqkdqkkdkg.vpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitc
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1900-2185 1.6e-74 245.6 In-house 2-280 (315) alignment 
Range on Protein: 1900-2185
Range on HMM: 2-280/315.0
PIKINQFEGHFMKLQadSNYLLSKEYEELKDVGRNQScDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPG
|| . ||     | .     |.|.|. .| |    .   .|  ..|  ||||.||||.| .||||  .||.| |||||||||.. .  . || .||||. 
pipvaqfpafvnknr..htalfseefhdlpdPdiyrq.rvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlka

TKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPA-DQDSLYYGDLILQMLSESVLPEWTIREFkicGEEQLDAHRLIRHFHYTVWPDHGVPETTQSL
. ||||.||....|  |||||.  |  ..||  |||  . ||  .| . ...|| .   . ..|..   .  . ...| .  |..| |||.||.. | ||
svddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl...vtrkseesrtvtqfqftewPdkGvdkqtssl

IQFVRTVRDYinRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRAR
..... |.    . .   . .||||||||||| .|..| ...|.  ..|||..  |. || .|...|||| .| .... |.. |  |
lklikevkad..ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwr
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1900-2179 1.5e-73 242.5 In-house 5-276 (315) alignment 
Range on Protein: 1900-2179
Range on HMM: 5-276/315.0
PIKINQFEGHFMKLQADSNYLLSKEYEELKdVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPG
|| ..|.  .  . .| ..  . ..|| .   |. .  |.|   ||. |||| ||..|| .||.|  .. || |||.||..|.| | .| || .|||.. 
pipldqlityvaqkkastkngfkqdyesip.ggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnva

TKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADqdSLYYGDLILQMLSESVLPEWTIREFKICGEEQLdahRLIRHFHYTVWPDHGVPETTQSLI
. .|||..|.|... .|||.|. ||. . |...||| .   . || . . . || |  |.|.| . .  ....   | .  .||| ||| |||. | .|.
svkdfwrlvfeedigkivmltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsvvfgdni...revvqlhytswpdmgvpkytiplm

QFVRTVRDYINRSPgaGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVR
...|||. . . |   |. |||||||||||||||.|| .|.|.. .. .|.| ... .|  |..|||.  || .... . 
nlirtvkqhhtnsv..gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydall
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1900-2182 3.6e-55 182.0 In-house 3-236 (392) alignment 
Range on Protein: 1900-2182
Range on HMM: 3-236/392.0
PIKINQFEGhFMKLQAdSNYLLSKEYEELKDVGRNQScDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPG
|| . ||   |.. .   . |...|. .| .    .   .|  . |  ||||.||||||..||||  .|| | |||.||||||. .  . || .||| . 
pipvaqfpa.fveknr.hsalffeefhdlpgpdiypq.tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaa

TKDDFWKMVWEQNVHNIVMVTQCVEKGrvkcdhywpadqdslyygdlilqmlsesvlpewtirefkicgeeQLDAHRLIRHFHYTVWPDHGVPETTQSLI
. ||||.||...||  |.|||.  |                                              . | .| .  ||.| |||..||. | ||.
slddfwrmvfqenvttiamvtklkegd............................................kgddartvaqfhftewPdkdvpkhtssll

QFVRTVRDyiNRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVL
.|.. |.   .    . | ..||||||||||  |..| .. .      ||..  | ..| .| .||||. || ... .| . |
kfikevka..dfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1900-1995 5.7e-11 36.5 In-house 4-95 (95) alignment 
Range on Protein: 1900-1995
Range on HMM: 4-95/95.0
PIKINQFEGHFMKLQADSNYLLSKEYEELKDVgRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDdpcSDYINASYIPGNNFRREYIVTQG
||..  |  | ......|.  . .|.  .       .  .     |  |||. ||.||||||| |.   |   |||||| .. |   .  || .||
pihvsvfhshvlemhsnsdqefdnefksismt.sgapytvgsseanipknrflnifpydatrvvlttkrd...sdyinacfvdgyarkncyiaaqg
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1901-2187 5.3e-102 336.1 In-house 2-285 (318) alignment 
Range on Protein: 1901-2187
Range on HMM: 2-285/318.0
IKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGT
|.....| |  .|... . |||.|||.|. . .. .   .| | |. ||||.|||.|| |||||....... ||||||.||.|.. ...|| .|.||| |
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

KDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQdSLYYGDLILQMLSESVLPEWTIREFKICGeEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQ
 .|||.||||||   |||.||..|.|..|...||| .. |  ||.|  .. .|  | ....||||.   .. ...| .| .||| |||.|||| . ||..
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskg.srsygklvvelkeevelsdyvlrefkvtr.teeeesrqvrqyhytsWpdegvpesgaslld

FVRTVRdYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKL
.||.|. ......||||.||||||||||||.|||.| .|...     ||... |. || .|  ||||| ||..... . . | . ..
lvrqvs.kaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdt
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1901-2185 6.2e-94 309.3 In-house 4-282 (288) alignment 
Range on Protein: 1901-2185
Range on HMM: 4-282/288.0
IKINQFeGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGT
|.|..   . .| .|...  .|.||. |  .....| ... |..|  ||||.|||||| .|||| .... . .|||||||| |.. ...|| |||||. |
ihispv.akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladt

KDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICgeeQLDAHRLIRHFHYTVWPDHGVPETTQSLIQ
 .|||..|.|.... |||.|. ||.|. ||..|||....   ||.. ......  | ... |.. .    .   .. | ...|..|||||||| .. |..
vndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskaplle

FVRTVRDyINRSPgAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRAR
..|.|    | .  .|| .||||||||||||||||| ........| .|. |.|. || .|  .|||. ||....... ..  ..
llrqvkv.anqad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslieed
subfamily_PTPRG_pd Subfamily PTPRG 1901-2186 4.6e-91 300.7 In-house 1-291 (563) alignment 
Range on Protein: 1901-2186
Range on HMM: 1-291/563.0
IKINQFEGHFMKLQADSNYLLSKEYEELKD--VGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCS-DYINASYIPGNNFRREYIVTQGPL
.....|. | ..| ||..  .|.|.|.|.   . ..  .. .  |||. |||| ||..|| .|||||.. .   . |||||.|| | .  ...|.|||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

PGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPAdQDSLYYGDLILQMLSESVLPEWTIREFKICG-----EEQLDAHRLIRHFHYTVWPDHGVP
. | ||||.|.|||||. |||.|. ||.|| ||| |||. ..|. || | ... .| ||   |.|...|       ..| | ..|.|..||| |||||||
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvP

ETTQSLIQFVRTVrdYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARK
| .   ..||.       .   |||.|||||||||||||.|.|| .|.|. ....|...| .. .|..| ..|||| ||..||. . .......
ehslpvLifvkks..saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiaske
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1901-2181 2e-64 212.3 In-house 2-282 (290) alignment 
Range on Protein: 1901-2181
Range on HMM: 2-282/290.0
IKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDD--DPCSDYINASYIPGNNFRREYIVTQGPLP
|....|  . .. .|  |    .... |.   ....  ..| ..|. .||..||..||  |. | .. .  |   .||||.|| | . ...||.||||..
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

GTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLyYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHG-VPETTQS
 |  ||||..|...|  |||.|. .|.|.|||  |||. . .  ||   ...|.|..| | ..|....  ... .|.. . ... | |...| |.... .
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqti

LIQFVRTVRdyINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDV
|... . ..  ..| .| .. |||||..|||...|.|..  ...  ..  .|..  .. .|  .  .|||. || ...| |   
llvieemyk..tqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlty
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1902-2188 3.7e-64 211.4 In-house 3-284 (287) alignment 
Range on Protein: 1902-2188
Range on HMM: 3-284/287.0
KINQFEGHFMKLQADSNYLLSKEYEELKDVG-RNQSCDIALLPENRGKNRYNNILPYDATRVKLSnvddDPCSDYINASYIPGNNFRREYIVTQGPLPGT
 ...|     | .| .|   .. .  |..|. |...  ... ..|. |||...||..|  || |     .   |||||..| | . ....|....|.  |
pvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfnt

KDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDsLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHG-VPETTQSLI
  .|||.....||. |||..|  |. . .| .||| ..  ...|.  ...|.| |  ....|....  ... .... .. ...| |...| |.|   .|.
arnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtill

QFVRTVRDyiNRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLR
.. . ..   .| .| .. |||||..|||...|.| .  ... .    .|..  ..  |  . ..|||  || .. . |   | . ...
vieemykt..qrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfety
0040438 (Phosphotyrosine protein) phosphatases II 1904-2194 2.5e-102 337.7 In-house 3-288 (317) alignment 
Range on Protein: 1904-2194
Range on HMM: 3-288/317.0
NQFEGHFMKLQADSNYLLSKEYEELKDVGRNqSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDD
.... . ..| . ....|..|.|.| ..  . ....|.||||..|||| .|||||..|||||... |. ||||||||..| |..|..|.||||||.| .|
ldlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntved

FWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPAdQDSLYYGDLILQMLSESVLPEWTIREFKICGEeQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVR
||.|||||.|. |||.|...|.||.||..|||  ...|.|||.. ..||| .|...|.|.... .  . . .| ..||||| |||||||.....|..|..
FwrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfle

TVRDYINrsPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENP
 ||....  .. ||..|||||||||||||||....|.||. .  ||.. ||. || .| ..|||. ||..|...... |. .  . .  ..
avreale..dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepasel
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1904-2180 3e-65 215.4 In-house 5-277 (439) alignment 
Range on Protein: 1904-2180
Range on HMM: 5-277/439.0
NQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPEN--RGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTK
..|. |  ||. . . ......|... .  . .|. .|. ..  . ||||... ..| ||| | ..   | | |||| || |    . || ||||   | 
defqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkett

DDFWKMVWEQNVHNIVMVTQCVEKGRvkcdhYWPADQDsLYYGDLILQMLSESVLPEWTIREFKICGEE-QLDAHRLIRHFHYTVWPDHGVPETTQSLIQ
||||..|.|... .|||.|. ||  .     |||.|..  .|||.....  .  ||...|| ||.  |  . .  | . .|||. |||. ||  .  ...
ddfwrlviekktvtivmltnlvesyk.....ywpsdae.vcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvld

FVRTVRDyINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRD
|.|..    | .   || ||||||||||||| ||||  |.|| ... ||| | |. || .| .|||. ||||.....| .
flrains.andkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_PTPRK_pd Subfamily PTPRK 1905-2179 2.8e-81 267.8 In-house 8-274 (314) alignment 
Range on Protein: 1905-2179
Range on HMM: 8-274/314.0
QFEGHFMKLQADSNYLLSKEYEELKDVgrnqsCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDF
    .  .|..  .| . .||| | .       | |   ||| |||...||.|| .||.|  .|.|| ||||||..| . .  ...|||||||. |  ||
dllqsiallkraegygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdf

WKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSlyYGDLILQMLSESVLPEWTIREFKICG-EEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVR
|..|...|   |||.|. ||.||||| .||| | .   |||. ..... ..| |  .| |...  . . ...|..|.|... ||||.||   ..|...||
WrlvydencasivmltelvevgrvkClkyWPedtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvr

TVRDYINRspGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVR
 |    .   .||..||||||| ||||||||.| .|. .. .. ||.. ||..|| ..| ||.|| ||..... . 
rvkksqee..eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvil
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1908-2180 2.8e-60 199.1 In-house 12-286 (325) alignment 
Range on Protein: 1908-2180
Range on HMM: 12-286/325.0
GHFMKLQADSNYLLSKEYEELKDVGrNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKM
 |  | .|. .  ...|.. |  ..  ..  .| .|||. |||..|....| .|| |   .||| ||||||||.  .  .  .. .| ||. | .|.|..
ehvekkkaqdqdgfahefgllpsdd.giakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrl

V--WEqnvHNIVMVTQCVEKGRVKCDHYWPAD-QDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDaHRLIRHFHYTVWPDHGVPETTQSLIQFV--
|  |.     .|.|.  ...|  .|  ||| .  .|  .| | ... .   . ..  | ... . .. .  | .. |..  |.| ||..   .|| ..  
vldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGe.trsvkqfqlqswddmGvqkrpatlisilql

-RTVRDYINR-SPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRD
  .| . ..  . ...| .|||||||||||.||.|  .|...  . .|||.| |. || .|  ||.|  ||. ..... .
vkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealve
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1909-2183 2.1e-91 300.9 In-house 5-277 (281) alignment 
Range on Protein: 1909-2183
Range on HMM: 5-277/281.0
HFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMV
|. .|....|  . .|||.|...|....   .  .||. ||||.||  |||||||... ...  .|||||...|| .  .|||.||||.| . ..||.||
hlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmv

WEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKIcgEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDY
|||.|. |||||. .|.|..|| .||| |. .| |||.......|.  ...  |.||.  |..   .| .....|| |||||||.||. |..| . |. .
weqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlkl

INRSPGaGPTVVHCSAGVGRTGTFIALDRILQQLDSK-DSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLR
 ...    | |.|||||||||||.|||||........  ..|.   |..|| .|  ||||  || .... | |.| 
tekktk.aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
0036941 (Phosphotyrosine protein) phosphatases II 1911-2188 4.3e-102 336.6 In-house 5-283 (297) alignment 
Range on Protein: 1911-2188
Range on HMM: 5-283/297.0
MKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLsnvdDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWE
.. ......||.||.||| ..  . |...||||||. |||| .||||| |||||    ||. ||||||||..| .. |..|.||||||.| .|||.||||
llekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvwe

QNVHNIVMVTQCVEKGRVKCDHYWPAD-QDSLYYGDLILQMLSESV--LPEWTIREFKICGEeQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRD
|||. |||.|..||.||.||..||| . ..||.|||.....||..|  |...|.|....    . . .| ..||||| ||||||||...||..|.. ||.
qnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt.gngesrtvthfhytgwpdhgvpespaslldfielvrk

YINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLD---SKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLR
... .|. ||..|||||||||.|||||.| .||||.       |||. ||. || .| ..|||. ||..|.... . |. ....
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltk
0047943 (Phosphotyrosine protein) phosphatases II 1914-2180 4e-98 323.5 In-house 7-270 (273) alignment 
Range on Protein: 1914-2180
Range on HMM: 7-270/273.0
QADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLsnvdDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNV
......|| .|.|.|...  . .. .||||||. |||| .||||| .||||    .|. ||||||||..| |. |..|.||||||.| .|||.|||||||
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

HNIVMVTQCVEKGRVKCDHYWPADQD--SLYYGDLILQMLSESVLPEWTIREFKICGEEQLDaHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINR
. |||.|..||.||.||..||| ...  ||.||...  .||| . . .|.|....   .  .  | ..||||| |||||||....||..|.. ||.... 
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalea

SPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRD
.|. ||.|||||||||||||||||| .|.||  .  ||.. ||. || .| .||||..||..|.... .
lpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
0045098 (Phosphotyrosine protein) phosphatases II 1916-2183 6.3e-88 290.0 In-house 4-273 (278) alignment 
Range on Protein: 1916-2183
Range on HMM: 4-273/278.0
DSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKlsnvdddpcsDYINASYIPGNnfRREYIVTQGPLPGTKDDFWKMVWEQNVHN
.... |. |.|.|   | ....  ||...|. |||| .||||| .|||          ||||||||.|   ....|.|||||| | .|||.|.||.... 
lasldlllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitv

IVMVTQCVEKGRVKCDHYWPaDQDSLYYGDLILQMLSESVLPEWTIREFKICGE---EQLDAHRLIRHFHYTVWPDHGVPETT--QSLIQFVRTVRDYIN
|||.|..||.||.||..||| ...||.|||. . .|||.||...|.| ....     .. .  | ..|.||. |||||||...  .|...... .|....
ivmltelvelgrekcaqywp.eggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealk

-----------RSPGAGPTVVHCSAGVGRTGTFIALDRILQQLdsKDSVDIYGAVHDLRLHRVH-MVQTECQYVYLHQCVRDVLR
             .. ||..||||||||||||..|.. .|..|  .. ||.. ||. || .| . .||.. ||..|.......|.
llaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_PTPN23_pd Subfamily PTPN23 1916-2178 2.5e-60 198.8 In-house 12-276 (288) alignment 
Range on Protein: 1916-2178
Range on HMM: 12-276/288.0
DSNYLLSKEYEELKDV----GRNQSCDIALLpeNRGKNRYNNILPYDATRVKLSNVDDdpcsDYINASYIPGN-NFRREYIVTQGPLPGTKDDFWKMVWE
| .  | |...||..      |..|. || |  .  |||...||||| .|||| .  |    ||||||.. .      ..|.||.||..|  |||.||.|
dgktaldkkfkeleqkqdkearkrsiaiakl..yseknrsrdilPyDhnRvklrgskD....DYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvye

QNVHNIVMVTQCVEKGRVKCDHYWPADQDS-LYYGDLILQMLSESVLPEWTIREFKICGEeQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRD--
| .  |||...  |.|. |.|.|||.|..    .||| . . |.  ....  |..|.  . . || . ..| ..| ||..|||.. ..|.||.  |..  
qkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletl.dadavksvshlqltsWpelGvPasPetllqfldevesay

YINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDS-VDIYGAVHDLRLHRVHMVQTECQYVYLHQCV
. .. .   | ||||||||||||.|  .  ....|. ..  .||   |. ||  | .|||.. |.  . . |
eavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeav
subfamily_PTPRN_pd Subfamily PTPRN 1916-2180 2.6e-54 179.0 In-house 26-290 (297) alignment 
Range on Protein: 1916-2180
Range on HMM: 26-290/297.0
DSNYLLSKEYEELKDVGRNQ-SCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRR-EYIVTQGPLPGTKDDFWKMVWEQNV
  .  |.||.| |..   .. ....|  ..|  |||....|||| .||||..  ..  ||||||| |  .. |.  || |||||. |  |||.||||| |
knkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGv

HNIVMVTQCVEKGRVKCDHYWPADQDSLYyGDLILQMLSESVLPE-WTIREFKICgEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYInRS
  ||..|.  |.|  .|..||| .  ..| .   ....|| .  . . .| | .  . | .  | .  ||.  ||..||| ...||..| | |     | 
vvivnltrleeegvkqckrywpdeGsevy.hiyevhlvsehiwcddylvrsfylk.nlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksy.rG

pGAGPTVVHCSAGVGRTGTFIALDRILQQLD-SKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRD
  . | |||||.|.||||..|..| .|..|      .||  ..  ||  | ..|.|. |. .  ..| .
.rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1916-2185 4.3e-49 161.8 In-house 13-296 (301) alignment 
Range on Protein: 1916-2185
Range on HMM: 13-296/301.0
DSNYlLSKEYEELKDvGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDD-DPCS-DYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNV
 ||  ....|.|||. |...||.. |  ||.  ||..|| .||  |. |..  . | |. .||||||| | . ....|..|||.  |  |||...|.. .
hsnk.feeqykelke.gedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekp

HNIVMVTQCVEKGRVKCDHYWPA-DQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRL--------------IRHFHYTVWPDHGVPETTQSL
 .|||||.  |. . || .|||  ...| ..| .  .. .| |.|...||....  ..  .  ..              .  .. | ||..||    .  
vsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtv

IQFVRTVRdYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRAR
.| .  |  . ....| || |||||..|.|.|......  | |  .   ||... .. .|  .  .|.|  ||. ... .   |.  
Lqviddvi.hrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqln
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1916-2180 8.3e-40 131.5 In-house 3-257 (267) alignment 
Range on Protein: 1916-2180
Range on HMM: 3-257/267.0
DSNYLLSKEYEELKDVGRNQS-CDIALLPENRGKNRYNNILPYDATRVKLSNVDDDpcsdYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVH
|..  . ||.|..| .  ..| .   .  .|. .||... |||| ||| |.. ...    ||||||. | . .. .||||.||  |  ||.... .|.| 
deeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvp

NIVMVTQCVEkGRVKcdHYWPAD-QDSLYYGDLILQMLSESVLPEWTIREFKICGEEQlDAHRLiRHFHYTVWPdhgVPETTQSLIQFVRTVRDYINRSP
 ||..|.  . . ..   .||    ..  | || ..   |    .. |  ...  ...  || .   ..|  |    .    .  .. .  .    .   
vivlltkvft.dnir..lfwPPkmgqakkyqdltvehslekeendyqiitlelkfkne.sahnv.tlyyykkwn...intnnkpylkplfgilaknqlen

GAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRD
|  | ||.||.||||.|||. .|  |...   . .||.  .  .|  |. .|.|  .|.|.|. . .
gnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1917-2180 1.2e-73 243.2 In-house 32-289 (319) alignment 
Range on Protein: 1917-2180
Range on HMM: 32-289/319.0
SNYLLSKEYEELKDVGRNQS-CDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHN
    |  |.  . ..| | .  . | |..|. |||. |||..| ..||| ...    |||||||.. |   .  || .||||. | .|||.|.||.|.  
dltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncst

IVMVTqcvekgRVKCDHYWPADQDSLY-YGDLILQMLSESvlPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPG
||..|      . ||  ||| . .  .  ... .... |.   |...|....  . .    | |. ||.  |||.|||. .  |...|. ||   ..  .
ivllt......kdkcsqywplkivikeerfkvkvdsveet..aeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenh

AGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRD
  . ||||||||||||..|.|| .|.... .. ||.|  |.|||  | ..||   || ...  . .
ranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1918-2184 4.8e-83 273.8 In-house 26-292 (298) alignment 
Range on Protein: 1918-2184
Range on HMM: 26-292/298.0
NYLLSKEYEELKDVGR---NQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVH
   ...|...|. |     ... ..|  |||. |||| .|...| .|| |...|.|  |||||||.. . . |  .|.||.||. |  |||.||.|... 
ltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedig

NIVMVTQCVEKGRVKCDHYWPADqDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLdAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDyINRSPG
 |||.|. .|....|. .||| .  .  ||.. ...||. .  . ..|..|.  ...   .| .|..|.|.|||.||||...|.....| ||   ..  |
tiVmltnleeldktkyhkywPde.gketygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqag

AGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRA
  | .|.|||||||.|||||.| .|...  . .||.. .|. || .|...|||| |||.... | ..| .
nkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealds
subfamily_PTPN6_pd Subfamily PTPN6 1920-2186 2.1e-80 265.0 In-house 27-301 (306) alignment 
Range on Protein: 1920-2186
Range on HMM: 27-301/306.0
LLSKEYEELK--DVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSnVDDDPCSDYINASYIPG--NNFRREYIVTQGPLPGTKDDFWKMVWEQNVHN
 ...|.|||.  .. .  | . .  |||. ||||.||||.| |||.|.  .. | ||||||.|| .  .. ...|| ||| |. |  |||.|||..| . 
gfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrv

IVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSP--
|||.|. ||.|. || .|||. ...  ||.. ....||. | ....||.... ... . .| ....|...|||||||. .. ...|...|.   ...   
ivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleea

GAGPTVVHCSAGVGRTGTFIALDRILQQLDSKD---SVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARK
 |||.|||||||.||||||| .| .|... .|     .||. .|. .| .|  .|||| || .... ..  ....|
eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk
subfamily_PTPN9_pd Subfamily PTPN9 1920-2178 7.2e-79 259.9 In-house 17-286 (297) alignment 
Range on Protein: 1920-2178
Range on HMM: 17-286/297.0
LLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMV
 |||||.|...   .   . . |. |  ||||...| || |||.|..||.|..||||||... | . .. .| |||||. | .|||.|||||.|  |||.
GlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmt

TQCVEKGRVKCDHYWP-ADQDSLYYGDLILQMLSESVLPEWTIREFKICGEeQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYIN--------
|..||.||.|| .|||  ...|  .||| .. ..  .  ....| ..|    . . .| . || .. |||.|||....||......||..          
trvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknv.kteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgd

---RSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV
     |   | |||||||.|||||||.||  |..|.... ||.  .|. ||  | ...||. ||.. ...|
ewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylav
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1920-2185 2e-73 242.3 In-house 19-279 (515) alignment 
Range on Protein: 1920-2185
Range on HMM: 19-279/515.0
LLSKEYEELKdvGRNQS-CDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVM
|.|.|. .|   | |     .|    |  ||||.|||||| .||||  ..|.| |||.||||||. .  . || .|||.. . ||||..|...||  |.|
lfseefhdlp..gpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiam

VTQCVEKGRVKCDHYWPA-DQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQldaHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPgaGP
||.  |  ..|| .|||    ||. .| . ....| .   . ..|....  ...    | .  ||.| |||.|||. |.||..... |.   ..     |
vtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd...srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt..hp

TVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRAR
 ..|||||||||| .|..| .. .    ..||..  |. .| .|...|||. || .... |.. |  |
liihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwr
0046845 (Phosphotyrosine protein) phosphatases II 1921-2184 4.7e-101 333.1 In-house 2-276 (284) alignment 
Range on Protein: 1921-2184
Range on HMM: 2-276/284.0
LSKEYEELKDVGRNQ--SCDIALLPENRGKNRYNNILPYDATRVKLSNVDDD-PCSDYINASYIPGN-----NFRREYIVTQGPLPGTKDDFWKMVWEQN
| .|.|||  .  ..  |...||||||. |||| .||||| .||||...|.| . ||||||||..|      ......|.||||||.| .|||.||||||
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

VHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRS
|. |||.|..||.||.||..||| ....|.|||..  .||| | . .|.|....  ..  . .| ..||||| |||||||.....|..|.|.||......
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

PGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKD---SVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRA
|| ||.|||||||||||||||||| .|.||. ..    ||...||. || .| .||||. ||....... . |. 
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
DSPc_SM00195 1921-2181 3.9e-91 300.4 In-house 2-261 (263) alignment 
Range on Protein: 1921-2181
Range on HMM: 2-261/263.0
LSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVT
|..|.|.|..   ..... |  ..|. ||||.|||||| |||||.. .... ||||||.|| |.| ...||.|||||| | .|||.||||..|. |||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

QCVEKGRVKCDHYWPAD-QDSLYYGDLILQMLSESVLP-EWTIREFKICGEEQlDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSpgAGPT
...|.|. |||.||| . ...  .|.. ... ..   . |...|....  |.. . .| .....|. |||||||..|.|.....|.|.   ..|   ||.
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpi

VVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDV
||||||||||||||...| ||..|.... |||   |  || .| .||||. || ...... ..
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 1921-2181 3.9e-91 300.4 In-house 2-261 (263) alignment 
Range on Protein: 1921-2181
Range on HMM: 2-261/263.0
LSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVT
|..|.|.|..   ..... |  ..|. ||||.|||||| |||||.. .... ||||||.|| |.| ...||.|||||| | .|||.||||..|. |||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

QCVEKGRVKCDHYWPAD-QDSLYYGDLILQMLSESVLP-EWTIREFKICGEEQlDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSpgAGPT
...|.|. |||.||| . ...  .|.. ... ..   . |...|....  |.. . .| .....|. |||||||..|.|.....|.|.   ..|   ||.
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpi

VVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDV
||||||||||||||...| ||..|.... |||   |  || .| .||||. || ...... ..
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
subfamily_PTPN14_pd Subfamily PTPN14 1921-2182 4.3e-60 198.2 In-house 25-296 (300) alignment 
Range on Protein: 1921-2182
Range on HMM: 25-296/300.0
LSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDpCSDYINASYIP--GNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVM
. .|||...    .  .. | ||||  |||....|||. .||.||   ..  ..||||| |       .|.|||.||||. |  |||.|||||.|. |||
vfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivm

VTQCVEKGRVKCDHYWPAD---QDSLYYGDLILQMLSESVLPEWTIREFKICGEeQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVR---DYINRS
.|.  |.|. |. .|.| .   .... .|   ..    .  .  . . .|.        .| . |. || ||||||||  .. ..... |.      |..
lteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhl.pskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnse

P----GAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVL
        | .|||||||||||  |  | ... |.  ...||  ... ||  | ..||| .|| .... .   |
veskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1921-2192 1.5e-45 150.5 In-house 21-281 (288) alignment 
Range on Protein: 1921-2192
Range on HMM: 21-281/288.0
LSKEYEELKDVGRNQSCDIALlpENRGKNRYNNILPYDATRVKLSnvddDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVT
| |||..  . . ... |  .  .|  ..||.|.   |.||||||    | .  ||.|  .. ....|  | .| || || . .|||. |..|. |||..
lkkeyrdspneasidiidsfi..anptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlc

QCVEKGRVKCDHYWPADQ-DSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVrdyinRSpGAGPTV
. .|||. | ..|.|  . ..  .| |  ..  . .  . ...   .  ... . . .... |.  |.|.||||  .| ....  .     .|    | |
ellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....ks.lqkPiv

VHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQE
||.|||||||||.|    .|..| ..| . |   .. || .| . .||| ||.|.|.|| . |  .| . ..|
vhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllkkykvlre
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1921-2190 9e-36 118.0 In-house 29-298 (310) alignment 
Range on Protein: 1921-2190
Range on HMM: 29-298/310.0
LSKEYEELkDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLsNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVT
| |.|  | |  ...|       ..  |||| ...  |..|||| ..|     ||| | |.  | .|  .|..||||  |  |||.|....    |... 
lvkqyrkl.dakqdssltyeaykkymhknrysdvvcldtsrvkl.kidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllc

QCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVlPEWTIREFK-------ICGEEQLDAHRLI--RHFHYTVWPDHGVPETTqsliqfVRTVRDYINR
. .|.|| ||  |||.   .  || . .  ||||   |. | ..        .  .||    . .     ..  ||| |||.        . || . .  
kvgeegrpkcvgywpslgvtetygcirvtnlsess.eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdek......chtvpqrlla

SPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSE
    || |||||||..|... .||.  ...||  . ||.   . .|. .|.  .||| ||.....      |. . ..|
qvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifargetevae
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1921-2192 8e-25 82.2 In-house 21-286 (312) alignment 
Range on Protein: 1921-2192
Range on HMM: 21-286/312.0
LSKEYEELKDVGRNQSCDIALlpENRGKNRYNNILPYDATRVKLSNvdDDpcSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVT
|.|||  . ..  .  |   |    .  ||| ||  .|  |  |.   |.    || | ..        ...|||||  |   ||...      .|....
ltkeykavgnivsdsectafl..kfkdlnrypniqcwdrgrftlag..de..nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillc

QCVEKGRVKCDHYWPAD------QDSLYYGDLILQM-LSESVLPEWTIREFKICGEEQLDAHRLiRHFHYTVWPDHGVPETTQSLIQFVRTVRDyinrsp
  || |  || .|          .|   | .   .. .        | | .|.      .  .|  |. .. |||||.|.. ..  ... .|.       
gfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqeskl.nhyqwaswpdhgmpdscdtalrllsavkk......

GAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQE
   | . |||||||||||.. .. ..  |      ..  .   ||  |   |..  ||||  .|| ..| .. |   .|
dkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykrne
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1921-2179 5.1e-24 79.2 In-house 28-282 (302) alignment 
Range on Protein: 1921-2179
Range on HMM: 28-282/302.0
LSKEYEELKDVGRN-QSCDiaLLPENRGKNRYNNILPYDATRVKLSNVDDdpcsDYINASYIPGNNFRREYIVTQGPLPGTK---DDFWKMVWEQNVHNI
. ||..... .  . ..|   .  .|  ||. ...  .|...|||..  |    .|.||| .   ...|. |..| |  ...   ..||.||..... ..
vkkefkkidtmkvdlekCk..afkknlkknqsedvpildsnlvkleaepd....syvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsv

VMVTQCVEKGRvKCDHYWP-ADQDSLYYGDLILQMLSESVLPEWT-IREFKICGEEQLDAhRLIRHFHYTVWPDHGVPETTQSLIQFVRTVrdYINRSPG
|.. .  |  .   ....|   .| ..||.. .     .   | .      .  |.  ..  |.   . | |... ||.   .||. .  |  . . ...
vilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsns.vlanvyvltnWkqkkvpvkyaeliktaakv..fakkika

AGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVR
  .||.    |.|| |.|..|   ...|.... . |   |. .|  | ..|.. .||| |. .. 
dentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1921-1984 4.6e-09 30.2 In-house 15-77 (244) alignment 
Range on Protein: 1921-1984
Range on HMM: 15-77/244.0
LSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDpCSDYINASYIPGN
  .|.  | |  |.     |.|  |  |||| ||||.| ||| ||.   .  ||||||.|| |.
akeefvglsdhtreflqtnavlsanatknryinilpfdetrvilssskke.gsdyinanyiqgs
subfamily_PTPN13_pd Subfamily PTPN13 1922-2183 1.8e-73 242.2 In-house 14-270 (273) alignment 
Range on Protein: 1922-2183
Range on HMM: 14-270/273.0
SKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDdpcsdYINASYI--PGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMV
..|..||...   ..|...   ||. |||| |.||||.|||||..        |||||.|  | .. . |||..||||| | .|||.|||||... |.||
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv

TQCVEKGRVKCDHYWPADQDS--LYYGDLILQMLSESVLPEWTIREFKICGEeQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINrspGAGP
|. .|||.|||. |||  ...    .. | ...|    | ....|....    .  . | . |.... ||||||| ....|.|||. ||   .    |||
tlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkds.esgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt...dagP

TVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLR
 |||||||.||.||.|..| .|. .. . ..|.   |..||  |  .|||. ||.. .. . .||.
ivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1922-2181 2.3e-45 149.5 In-house 30-282 (290) alignment 
Range on Protein: 1922-2181
Range on HMM: 30-282/290.0
SKEY-EELKDVGRNQSCDIALLPENR--GKNRYNNILPYDATRVKLSNVDDdpcSDYINASYIPGNNfrREYIVTQGPLPGTKDDFWKMVWEQNVHNIVM
.||| |.||     |  .  .. .|    |||| ..   | ||| |..  |    ||. | |. | .    .|.|||.|  |  |.|.|| ...|  |||
akeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGyd...GdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivm

VTQCVEKGRVKCDHYWPADQ-DSLYYGDLILQMLSESVLPEWT-IREFKICGEEQLDAHRLiRHFHYTVWPDHGVPETTQSLIQFVRTVRDYinrspgAG
. . .|.|. ||..|.|  . . | .|.. .    |.   . .  . . .   ..   |.| .|..   |||. |. .| .|.. .|..|        .|
lceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehkl.khlkikswpdksvalstlallrtlrilrka......sG

PTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDV
| |||||||.||||||.|..  || |    ..|. . |  ||  |.  || . ||. | . . |.
pvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1922-2103 1.3e-38 127.5 In-house 10-191 (297) alignment 
Range on Protein: 1922-2103
Range on HMM: 10-191/297.0
SKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDddPCSDYINASYI--PGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMV
 .|.. | |  | .|   |  .    ||||..|| .| ||||| .|   . .||||| |.  | ..    ||..||||  | ||||..|.||.|  ||||
eaekdllldeargesfssakrnsslrknryrdilatddtrvkllrvi..terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmv

TQCVEKGRVKCDHYWPA-DQDSLYYGDLILQMLSESV--LPEWTIREFKICGEeqlDAHRLIRHFHYTVWPDHGVPETTQSLIQFVR
..  | || ||  |||  .|. |  ||.... ||.         . |...      . .| .||  .  |||||||   . | .|  
aklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyr...sesrvvrhvqflswpdhGvpsdledlvrfqa
subfamily_PTPN3_pd Subfamily PTPN3 1923-2181 5.6e-74 243.6 In-house 19-274 (280) alignment 
Range on Protein: 1923-2181
Range on HMM: 19-274/280.0
KEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDdpcsDYINASY----IPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVM
...|.|    .. ....| .|||  |||| .|||||||||||.. .     |||||.|    ||....   ||.|||||. |  |||.|||||... |||
aqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivm

VTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQlDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYinRSPGAGPT
.|. ||.||||| .|||  .|.| ||.. ... .|.   .. .||. .. .|. . .| | .. |. |||||||. ......||..||..  ||    |.
lttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdket.keerkilqlqylaWpdhgvPddsadflefvervrkl..rsgkeePv

VVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDV
|||||||.|||| .|.|.  |. ......| .   |. .|  |  .|||. || .. ...  |
vvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_PTPN1_pd Subfamily PTPN1 1923-2175 3.8e-70 230.9 In-house 10-264 (290) alignment 
Range on Protein: 1923-2175
Range on HMM: 10-264/290.0
KEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDdpcsDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQC
. |.....  .. ..  | |||||..||| .. ||| .|.|| . |     |||||| .  .. .|.||.|||||| | | ||.|||||. . .||. ..
eiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkv

VEKGRVKCDHYWPADQD--SLYYG--DLILQMLSESVLPEWTIREFKICGEeQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPT
|||...|| .||| ...  .| .    | ....|| .  ..|.| ...    . .  | | ||||| ||| ||||. .....|.  ||.    |.  ||.
vekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenl.ktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpa

VVHCSAGVGRTGTFIALDRILQQLDSKDS---VDIYGAVHDLRLHRVHMVQTECQYVYLH
|.|||||.||.|||. .| .| ... ||    |||   . .|| .|. ..||  |  . .
vihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsy
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1923-2186 3.8e-42 138.9 In-house 15-273 (281) alignment 
Range on Protein: 1923-2186
Range on HMM: 15-273/281.0
KEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSN-VDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQ
.|. .|      . | .   | |  |||| ||   | .||.|   . .   .||| | ||    ..| ||.||||   |. |||.|.|..|   |||. |
qefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcq

CVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLP-EWTIREFKICGEEQldaHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRdyiNRSpgaGPTVV
 .|  | ||  |.| .       | .     .| .        ...  | .    ||| |. .  |||  |||... ... .| .|    ||    | |.
fletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyege...trlithwlwkewpdwqvpessevmlkilrkir...ars...tppvi

HCSAGVGRTGTFIALDRILQQLDSKDSV-DIYGAVHDLRL-HRVHMVQTECQYVYLHQCVRDVLRARK
||||||||.||..|..  || . |. .. ||   |  ||.  |   |||  ||. . . . |.  | |
hcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgvayk
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1923-2094 2.1e-09 30.5 In-house 3-157 (169) alignment 
Range on Protein: 1923-2094
Range on HMM: 3-157/169.0
KEYEELKDVGRNQ--SCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINAsyipgnnfrreyivtqgplpgtkddfwKMVWEQNVHNIVMVT
|.|.|||.. .       .| |  |  |||    |    |||||  | .|  ||||||                           .|.|| |   ||.. 
kgynelkefmktieynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlg

QCVEKgrvkcDHYWPADQDSLYYGDLILQ---------------MLSESVLPEWTIreFKICGEEQLDAHRLIRHFHYTVWPDHGVPET
.. .|     . .||  .|   .  .||                .... |   . .    .  . . |    .. .||..||. |||..
dtddk.....nnfwpekedyqlhpavilgewytdslyvrtdkvhantsgveglfev..smvihsydddvteklsllhystwpqngvpqs
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1923-2094 2.8e-09 30.0 In-house 2-156 (169) alignment 
Range on Protein: 1923-2094
Range on HMM: 2-156/169.0
KEYEELKDVGRNQ--SCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINAsyipgnnfrreyivtqgplpgtkddfwKMVWEQNVHNIVMVT
|.|.|||.. .       .| |  |  |||    |    |||||  | .|  ||||||                           .|.|| |   ||.. 
kgynelkefmktieynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlG

QCVEKgrvkcDHYWPADQDSLYYGDLIL--------QMLSESVLPEWT----IREFKICGE-EQLDAHRLIRHFHYTVWPDHGVPET
.. .|     . .||  .|   .  .||         . .. | |. .    . |  .. .  . |  . .. .||..||. |||..
dtddk.....nnfwpekedyqlhpavilGewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqs
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1926-2179 1.6e-69 229.1 In-house 9-265 (274) alignment 
Range on Protein: 1926-2179
Range on HMM: 9-265/274.0
EELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKL-SNVDDDPCSDYINASYIPGNNFR-REYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCV
.|  ..  | . .   .. .  ||||..||| . .|| | |.  .|. |.|||| || | . . . |. |||||| | .|||.|.....|. |||.|.  
keflelPlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklk

EKGRVKCDHYWPADQDS---LYYGDLILQMLSESVLPEWTIREFKICGEEQldaHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGA-GPTV
|. . || .|.| ..|      |||. ... .     ....|.. .   |.   .| . |. || |||| .|. ...|...|. |..  ...    .|.|
eaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvv

VHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVR
||||||.|||| ||| .  ..||. .  ||. . | .|||.|  ||||. || ..|. . 
vhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1926-2178 7.8e-52 170.9 In-house 13-262 (283) alignment 
Range on Protein: 1926-2178
Range on HMM: 13-262/283.0
EELKDVG-RNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDdpcsDYINASYIP---GNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQ
| || ..  ....|||   ||. |||...|.|.|  ||.| .       |||||..||    ..  ..||..|.||  |. ||||||.....  |||.|.
evlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltk

CVEKGRVKCDHYWPAdQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVrDYINRSPgAGPTVVH
  |  |.||  |||  . |  ||.. . .  |     ..|.|. .  .    .  |. |. .  | . |      ||..| . .    ..|.  || |||
lqedlrikCsqyWPk.rGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvi.slqtesk.kgPivvh

CSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV
||.|.|||..|||.   .... ..  ||..  |. .| .|. .|||  ||  .|. |
CstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_CG42327_pd Subfamily CG42327 1926-2107 6.1e-26 85.8 In-house 9-192 (319) alignment 
Range on Protein: 1926-2107
Range on HMM: 9-192/319.0
EELKDVGRNQS-CDiALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNN-FRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCV
||..|. .  . .| .. .  . |.|. |..|   ||| | .. ||. . |..|||. | .  .  || .| .|  .  |||..||||.   || .|.  
eefrdlPqliarad.evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdls

EKGRVKCDHYWPADQ---DSLYYGDLILQMLSESVLPEWTIREFKICGEEQlDAHRLIRHFHYtVWPDHGVPETTQSLIQFVRTVRD
|.|  .| .|.|. .   .   |||. . .    |  .. |  . .   .. .  | . |. |  |.. .||   ..||  .  ||.
elGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdk.eesrelthywy.kwleaevPaeeaaliamllevrs
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1927-1986 5.3e-12 39.8 In-house 29-88 (440) alignment 
Range on Protein: 1927-1986
Range on HMM: 29-88/440.0
ELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNF
 |   |  | .||| ||.|. |||| ||| || .|| | .|   | ||||||||| | . 
sllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingies
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1931-2180 3e-72 238.5 In-house 10-253 (284) alignment 
Range on Protein: 1931-2180
Range on HMM: 10-253/284.0
VGRNQ-SCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTqcvekgRVK
.| |      | |..|. |||. .||..| ..||| ...    |||||||.| |   .  || |||||. | .|||.|.||.|.  ||..|      . |
lgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdk

CDHYWPADQDSLY-YGDLILQMLSESvlPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGR
|  ||| . .  .  ... .....||   |...|....  . .    | || ||.  |||.|||. .  |...|. ||   ..  .  . ||||||||||
csqywplkivikeerfkvkvdsvees..eeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgr

TGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRD
||..|.|| .|.... .. ||.|  |.|||  | ..||  .|| ...  . .
tgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
0049772 (Phosphotyrosine protein) phosphatases II 1932-2183 1.3e-51 171.5 In-house 33-281 (314) alignment 
Range on Protein: 1932-2183
Range on HMM: 33-281/314.0
GRNQSCDIALLPENRGKNRYNNILPYDaTRVKLSNVDDDPcSDYINASYIPGNnfrREYIVTQGPLPGTKDDF----------WKMV--WEQNVHNIVM-
 ..... .| |..|| |||| .|||.| .||.|.... .  ||||||||. |    . .|.|||||. | .||          |.||  ...||..||| 
lpeltilvadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivms

--------------------VTQCVEKGrvkcDHYWPADQDSLYygdlilqmlsesvlpewtirefkicgEEQ---LDAHRLIRHFHYTVWPDHGVPeTT
                     ... ..|    .....||.. |                           ||.    .  ||. ..... .||...| ..
rdevladelsrLdaAlgKtpllildgng....neptaadlellk..........................eelydpelferlgikylripvpDgsap.ll

QSLIQFVRTVRDYinrsPGAGPTVVHCSAGVGRTGTFIALDRILQQLdskdSVDIYGAVHDLRLHRV-----HMVQTECQYVYLHQCVRDVLR
. . .|.. ....    .  ||..|||.||.||||||.... .. .|     |..  |..|.|| |      ..... .||.. ...... |.
edfdeflefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylk
subfamily_CG7180_pd Subfamily CG7180 1933-2180 6.4e-64 210.4 In-house 30-288 (296) alignment 
Range on Protein: 1933-2180
Range on HMM: 30-288/296.0
RNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRvKCDH
..  |  .|  |||.|||. ...||| .|| |...| .  ||||||.|. .    .|||||..|   | |.||..|...... .|..|.  .  . ..  
eigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.myps

YWPADQdSLYYGDLILQMLSESVLPEWTIREFKICGE--------EQLDA-HRLIRHFHYTVWPD-HGVPETTQSLIQFVRTVRDYINRS---PGAGPTV
||| ..    ||........|  ... .||.||.  .        .| .|  |....|..|.|.  . ||  |..||...| || ....    |  ||.|
ywpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvv

VHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRD
|..| |..|.| ..|.|  |.... .. ||...||  || .| ..|..  .| |. . . .
vvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlle
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1933-2178 1.5e-39 130.4 In-house 48-285 (305) alignment 
Range on Protein: 1933-2178
Range on HMM: 48-285/305.0
RNQSCDIAllpenRGKNRYNNILPYDATRVKLsnvDDDPCSDYINASYIPGNNF-RREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCD
 ||| |||       ||||...   | . |||   |. . |||| | |.       . .|..||||  | |.|| || ...| .|||. . || |..|| 
anqsadia.....itknryqdvpcqdqsavkl...dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkca

HYWPADQDS--LYYGDLILQMLSESVL----PEWTIREFKICGeeQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDyinrspGAGPTVVHCSAG
.|||| |       . .... .| |      .|  |  ....     | .  .||...| ||| |||    . .... ..|          | |||||||
qywpaaqgeklelksgivvenvsgskpmerdaeiqitllnlty..sgdqkmsvrhlqwtewpdrgvppckltslellsairg......skvpivvhcsag

VGRTGTFIALDRILQQL-DSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV
.||||| .|.. ||... . |.   .   |. || .| . .|.. ||...|. .
igrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvm
subfamily_egg_pd Subfamily egg 1934-2182 4.3e-29 96.1 In-house 29-270 (307) alignment 
Range on Protein: 1934-2182
Range on HMM: 29-270/307.0
NQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKgrVKCDHY
..|   |.  .|. | | . .   | .||||         |.| | .. |. .  |.|..| ||  |.||||.||....|. |||.|  .|    .|..|
eislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyy

WP-ADQDSLYY--GDLILQMLS--ESVLPEWTIREFKICGEEqlDAHRLIRHFHYTVwpdhGVPETTQSLIQFVRTVRDYinrspgAGPTVVHCSAGVGR
|| |..||| .  | | .. |   .   | ... ..|. | .  |  | . |. . |           | .. .| .|.       . |.||..  || .
wpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd..deerflehwqgdv....nnssdvysplrvlrklrnl......skpvvvqdilGvsk

TGTFIALDRILQQLDS--KDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVL
..|..|..  | .|         .  ||  |||.|   |..  .|..... |  ..
aatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff
subfamily_PTPN12_pd Subfamily PTPN12 1935-2189 4.4e-77 253.8 In-house 30-283 (290) alignment 
Range on Protein: 1935-2189
Range on HMM: 30-283/290.0
QSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYW
 | . .  .||. |||| .||||| .||.||. .... ||||||..| | . . ||| .||||| | ||||.|.||.||. .||. . || |. ||..||
ysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYW

PAD-QDSLYYGDLILQMLSESVLP-EWTIREFKICGEeqlDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINrsPGAGPTVVHCSAGVGRTGTF
|   ...| .|.. ... .|  .  ...|| .|.  .   ...| .. |||| |||||||....||......||.. .    . | ||||||||||||| 
peegeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGrtGti

IALDRILQQLDSK---DSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRaRKLRS
||.| . ..| ..   ...|..  | .|| .|. .|||. ||......| .... ..|..
iaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq.kelei
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1935-2183 1.6e-70 232.2 In-house 10-265 (270) alignment 
Range on Protein: 1935-2183
Range on HMM: 10-265/270.0
QSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGN-NFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHY
.. |.     ..  |||..|||  ||||.|.....|. . |||| |..|  . ...|| ..|||| |  .||.|.||..|. |||.|. .|||| ||. |
sesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerY

WPADQDS---LYYGDLILQMLSESVLPEWTIREFKICgeEQLDAHRLIrHFHYTVWPDHGVPETTQ------SLIQFVRTVRDYINRSPGAGPTVVHCSA
|||....   | .|..    |||.    . ... ..   |. . .||. ||.|. |||||||....      .|.. .|.|| . ..   |.|..|||||
Wpaepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsa

GVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLR
|||||||.|||| ... |... .||.   ...|| .|. .||.  || .|.. |.   .
GvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
0040439 (Phosphotyrosine protein) phosphatases II 1936-2181 2.2e-89 294.6 In-house 2-245 (249) alignment 
Range on Protein: 1936-2181
Range on HMM: 2-245/249.0
SCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWP
....||||||. |||| .||||| .||||| ... ..|||||||||.| .. |..|.||||||.| .|||.|.||.... |||.|..||.||.||..|||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

AdQDSLYYGDLILQMLSESVLPEWTIREFKICGEeQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIAL
  ..||.|||.  ..||. |....|.|....    . . .| ..|..|| |||||||.....|..|.. ||..... |  ||..|||||||||||||||.
l.ggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

DRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDV
. .|.||. .  ||.. ||..|| .| ..||.. ||..|...... 
ylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1936-2177 6.9e-31 102.3 In-house 26-265 (285) alignment 
Range on Protein: 1936-2177
Range on HMM: 26-265/285.0
SCDIALLPENRGKNRYNNILPYDATRVKLSNVDddpcSDYINASYI--PGNNfRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHY
 |  .    |   ||| ..   . ||| | | |     ||| ||..  ||.. .  || |||||| |  |||.|......  ..|.   .| |  ||  |
nctytayeanpdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkd.qstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcaly

WPADQD-SLYYGD--LILQMLSESVLPEWTIREFKICGEEQLDAHRL-IRHFHYTVWPDHGVPETTQSLIQFVRTVRDyINrsPGAGPTVVHCSAGVGRT
.|      . .|   . |    |  .    .  . .   |.  .  | . | .   |||.  || .. .|.. . |.  .|  |   | .||||||||||
ypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkk.vn..pkekpicvhcsagvgrt

GTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQC
 ||. .|    ..  .  ...   |...|  |.. ||.  |...|.  
atfvgidyatirimenpniemldivremramrfqavqshmqflflyvv
0042113 (Phosphotyrosine protein) phosphatases II 1937-2181 6.9e-88 289.4 In-house 1-242 (245) alignment 
Range on Protein: 1937-2181
Range on HMM: 1-242/245.0
CDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPA
...||||||. |||| .||||| ||||||... |. ||||||||..| .. . .|.||||||.| .|||.|.||.... |||.|...|.|||||..||| 
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

dQDSLYYGDLILQMLSESVLPEWTIREFKICGeEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRsPGAGPTVVHCSAGVGRTGTFIALD
 ..||.|||.. ..||| .|...|.|....   .. | .| ..|.||. |||||||.....|..|.. ||..... .. ||..|||||||||||||||..
.gesltygdftvtllseehlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaay

RILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDV
..|.||..   |... ||..|| .| ..|||. ||..|...... 
lmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
0037934 (Phosphotyrosine protein) phosphatases II 1937-2180 7.7e-83 273.0 In-house 2-240 (243) alignment 
Range on Protein: 1937-2180
Range on HMM: 2-240/243.0
CDIALLPENRGKNRYNNILPYDATRVKLsnvdDDpcSDYINASYIPGNNfrReYIVTQGPLPGTKDD----FWKMVWEQNVHNIVMVTQCVEKGRVKCDH
. |||||||. |||| .||||| .||||    ..  ||||||..|.. .  | .|.||||||.| .|    ||.|.||.... |||.|..||.||.||..
fsiallpenlsknrysdilpydhsrvkl....eg..sdyinanliyvtp..r.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPadqDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINR------SPGAGPTVVHCSAGV
|||   .. .|||.. ..|||..|...|.|.....  .  | .||..|.||. |||||||.....|..|.. ||..|..       .. ||..|||||||
ywp...gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGv

GRTGTFIALDRILQQLdskdSVDIYGAVHDLRLHRVH-MVQTECQYVYLHQCVRD
|||||.||.. .|..|    .||.. ||..|| .| . .|||. ||..|..... 
gRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1937-2178 3.2e-45 149.5 In-house 33-273 (307) alignment 
Range on Protein: 1937-2178
Range on HMM: 33-273/307.0
CDIALLPENRGKNRYNNILPYDATRVKLSNvdDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPA
  .  .  |  ||||...   | .|. .    |  .|||| | |.      . .|..||||  |. .|| |. ...|  ..|. ...| ...||. |||.
vtveafsantdknryqdvkcqdkgrivvkf..dglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpl

DQD-SLYYGDL-----ILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINrspgagPTVVHCSAGVGRTG
..   | .|.      . .. .. . |.  . .      .  .  | |.|. .. |||.|||..  . | .. .||   |      | ||||||||||.|
eegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydtn......pvvvhcsaGvGrsG

TFIALDRILQQ-LDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV
| .|.  . .. .. ..  |.   |..|| .| . .||| ||.|||. .
tivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvl
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1940-2183 2.4e-76 251.3 In-house 4-243 (250) alignment 
Range on Protein: 1940-2183
Range on HMM: 4-243/250.0
ALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVkCDHYWPADQd
|  |.|. |||| .|...| .|| | ... |  |||||||.. | . |. .|.|||||. |  |||.||.|...  |||.|. .|.... . .|||... 
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek.

SLYYGDLILQMLSESVLPEWTIREFKICGEEQlDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYiNRSPGAGPTVVHCSAGVGRTGTFIALDRIL
.  |||. ...||. .  ..|.|..|.  ...   .|..|..|..|||| ||||.... ..... |.   ..  |..| .|.|||||||.|.|||.| .|
aekyGdvtvsllskeefadytkrklklskakk.aderivrqlhfvvWPdkgvPevatavLellkkvqas.qqqagnaPvivqCsaGvgrsGafiaidavl

QQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLR
..|  .  ||..  .. || .|.|.|... |||.... .   | 
erlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1941-2174 1.6e-35 117.3 In-house 48-273 (301) alignment 
Range on Protein: 1941-2174
Range on HMM: 48-273/301.0
LLPENrgKNRYNNILPYDATRVKlsnVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQ-D
 ||..  |.||...     | |.   | .|     | | .|| .   . .|.|||||. |..||| |.   .|..|||..| |||   ||..| | .  .
ylpkd..khryptvPckPstave...vivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkise

SLYYGDLILQMLSES-VLPEWT-IREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDyinrSpgAGPTVVHCSAGVGRTGTFIALDR
.|  |   ... ..  .| . .  |....    .  | | . |. |. |.|.|||..   | ...  |..    |    | |||||||.||. .||. . 
kldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk....s..ekPivvhcsaGiGrsvafigtey

ILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYL
. ......  ...  |...|| || . |||. |  ..
lareveadptieltealkhlrehrwngvqtnsqlywm
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1942-2187 1.4e-67 223.0 In-house 45-289 (297) alignment 
Range on Protein: 1942-2187
Range on HMM: 45-289/297.0
LPENR---GKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFrrEYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRvKCDHYWPaDQ
  |..    |.||.||||||  ||||  |.||| |||.|||...||.   ..| || | . | .|||.||....|  |||...  |. . || .||. |.
vaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWs.dk

DSLYYGDLILQMLSESVLPEWTIREFKICGEeQLDAHRLIRHFHYTVWPDHGVPE--TTQSLIQFVRTVRDYINRSPGAgPTVVHCSAGVGRTGTFIALD
 .  .||. ...|| |       ||...  . .  |.|... .... |||. |..  ...||....  ||.  .    . | .|||.||||||| ....|
gvttfGdvsvvllsvsereGfikrelevtkg.kakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.PllvhclaGvGrtgvlltid

RILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKL
 .. .   ...|||.| |. || .|...|||. || .... | ..| . . 
svvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedt
subfamily_eak_pd Subfamily eak 1942-2105 4.9e-15 49.7 In-house 49-207 (332) alignment 
Range on Protein: 1942-2105
Range on HMM: 49-207/332.0
LPENRGKNrYNNILPYDATRVKLSNVDDDPcSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQ-DS
  |.  .|   .|.|||   |.|..   ..   ||||| .  ..  |.||.|  .       ||.|| ||.   ||.. . ||..  | | |.| .  . 
rleavnrn.vvkivpydrylvrltssqlnr.lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktree

LYYGDLILQMLSESVLPEWTIREFKICgeEQLDAHRlIRHFHYTVWPDHGVPETtQSLIQFVRTV
| .| | ..  .         | ...      ..|| . |...  | .  .|   . .. . ...
lkfGildverkefvkrniletrllels..kGnethr.vlhykvfGwtettlpky.edflalrkvm
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1944-2178 7.7e-63 206.9 In-house 2-235 (237) alignment 
Range on Protein: 1944-2178
Range on HMM: 2-235/237.0
ENRGKNRYNNILPYDATRVKLSNVDDDpcSDYINASYIPGNN-FRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLY
||. |||| ||  || .|| |     .  ||||||.|. | .   ..|| .||||  . ||||.|||...   |||.|  .|. ..|| .|||  ..   
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQL
|| | . .  .  . ..|.| . .  . .|   |||  ...|.|||.|||. | .|..| . . .  .  . .|| ..|||||||||| |. .| .|.| 
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

DSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV
  |  ||||  |. .   | ...||. |||..|| .
kekkvvdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_ptpA1_pd Subfamily ptpA1 1944-2144 2.1e-42 140.3 In-house 46-258 (418) alignment 
Range on Protein: 1944-2144
Range on HMM: 46-258/418.0
ENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNnFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPA----DQD
 |  |||| |||| . |||.| ...|   |||||| || |  . ...|.|||||| |  |||.||||. .. |||...  |. |.|||.|||     .| 
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqf

SLYY-GDLILQMLSESV-----LPEWTI--REFKICGEeqlDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDY----INRSPGAGPTVVHCSAGVG
|.|  |. ..   |  .      ||  |  |. ..  |      | | ...|  |||| .|. || . |..... .     |  |    | .||||||||
siygngnevfgtysvelveviqdpereiitrnirltfe...getrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvg

RTGTFIALDRILQQLDS
||||| .   ....|| 
rtgtfctavimmkkldh
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1944-2176 2.8e-24 80.3 In-house 46-273 (303) alignment 
Range on Protein: 1944-2176
Range on HMM: 46-273/303.0
ENRGKNRYNNILPYDATRVKLSNvdddpcSDYINASYIPGNNFRReYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYY
.|  |||. ...  | ..||||.      | || |||.  .  ..  |.|| ||. |  |||.|. ||.|. ....    |  ..  |  .| .|| | .
knmdknrfvdvicldhskvklsd......ssyihasyleldsskk.ailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

GDLILQMLSE---SVLPEWTIrefKICGEEQLDAHRLIRHFHYTVWPDHGVPET-TQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRIL
 .  ...       .   |..   |.    . | . ..   ||  ||   .|   .  ... .  .. .. .   . |||    .|.||.|||  ..   
eersirvgefkrvelgdgwvl...kvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetah

QQLDS-KDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQ
  | | . |.|.   .  .|  |.| ||  .|. ... 
lslhseqasldlvkclenvrngrlhavqnlsqfsvvyt
Y_phosphatase Protein-tyrosine phosphatase 1945-2178 7.7e-82 269.6 Pfam-A 1-233 (235) alignment 
Range on Protein: 1945-2178
Range on HMM: 1-233/235.0
NRGKNRYNNILPYDATRVKLsnVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWP-ADQDSLYY
|. ||||..||||| |||||   ...  ||||||.|. | .  ...|.|||||. | .|||.|||...|. |||.|...||||.||..||| ....||.|
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GDLILQML-SES-VLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYInrSPGAGPTVVHCSAGVGRTGTFIALDRILQQ
||. ...  .|.    |.|.|....  ... ...| ....||| ||||||||...||....| |. .   ..  ||.||||||||||||||.||| .|.|
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldilleq

LDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV
|.....||.. .|  || .| .|||.. ||..|....
leaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 1945-2178 7.7e-82 269.6 In-house 1-233 (235) alignment 
Range on Protein: 1945-2178
Range on HMM: 1-233/235.0
NRGKNRYNNILPYDATRVKLsnVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWP-ADQDSLYY
|. ||||..||||| |||||   ...  ||||||.|. | .  ...|.|||||. | .|||.|||...|. |||.|...||||.||..||| ....||.|
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GDLILQML-SES-VLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYInrSPGAGPTVVHCSAGVGRTGTFIALDRILQQ
||. ...  .|.    |.|.|....  ... ...| ....||| ||||||||...||....| |. .   ..  ||.||||||||||||||.||| .|.|
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldilleq

LDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV
|.....||.. .|  || .| .|||.. ||..|....
leaeeevdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1945-2177 3.1e-58 191.8 In-house 38-272 (287) alignment 
Range on Protein: 1945-2177
Range on HMM: 38-272/287.0
NRGKNRYNNILPYDATRVKLSNVdDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYG
.  |||| ..||.| ||| ||.   .  |||||| |... .   ..|..|||.. |  |||..|.|...  ....|. ||..| || .|||  .  .  |
avkknryadvlPiddtrvllsae.gelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvG

DLILQMLSESVL-PEWTIREFKICGEEQLDAhRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYIN--R-SPGAGPTVVHCSAGVGRTGTFIALDRILQ
   . .|. ... ||...| ...   |  .| |... ...  |||.... |. .||.||  |...|.  | . ..|| |||...|.||.|...|.  ...
GysvvlldydikePeygvralrlidletrea.rvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvs

QLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQC
.| .   ||.  .|  || .|  .||.  |. .| . 
rledlGrvdvaavvirlreyraalvqavvqlrllyea
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1945-2178 9e-57 187.0 In-house 7-236 (239) alignment 
Range on Protein: 1945-2178
Range on HMM: 7-236/239.0
NRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGN-NFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPaDQDSlYY
|. |||| ||. || .|| | .. .|| ||||||||.       . || ||| .  .  |||.|.|..    |||.|  .|  . || .||| |  |  |
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.dsts.ky

GDLILQMLSESVLPEWTIREFKICGEEQLDaHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDyiNRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLD
 .| . .    |. .. || | .    | .  | . ..|.|||||.|||. . ... . | .    .  ||| | |.||||||||||.|. .| .|.|  
cnlrvtlrktevfadyiirtfvmsqvgqte.eryvyqyhftvwpdkgvpqyatavlglrrkitk..dslpgarpwvihcsagvgrtgaflvidamlrqak

SKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV
 . .|||.  |. .|  | |||||  |||..| .|
kqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1945-2178 1e-56 186.8 In-house 8-237 (239) alignment 
Range on Protein: 1945-2178
Range on HMM: 8-237/239.0
NRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGN-NFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPaDQDSlYY
|. |||| ||. || .|| | .. .|| ||||||||.       . || ||| .  .  |||.|.|..    |||.|  .|  . || .||| |  |  |
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.dsts.ky

GDLILQMLSESVLPEWTIREFKICGEEQLDaHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDyiNRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLD
 .| . .    |. .. || | .    | .  | . ..|.|||||.|||. . ... . | .    .  ||| | |.||||||||||.|. .| .|.|  
cnlrvtlrktevfadyiirtfvmsqvgqte.eryvyqyhftvwpdkgvpqyatavlglrrkitk..dslpgarpwvihcsagvgrtgaflvidamlrqak

SKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV
 . .|||.  |. .|  | |||||  |||..| .|
kqktvdifnyvkairedrphmvqtseqyvfihlav
0041856 (Phosphotyrosine protein) phosphatases II 1945-2186 4.9e-54 178.0 In-house 1-175 (182) alignment 
Range on Protein: 1945-2186
Range on HMM: 1-175/182.0
NRGKNRYNNILPYDATRvklsnvdddpCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTqcvekgrvkCDHYWPADQdslyyg
|. |||| .||||| .|           .|||||... |.   ...|.|||||..|  ||..|..|.... ||..|         ...||| .       
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

dlilqmlsesvlpewtirefkicgeeqldaHRLIRHFHYTVWPDHGVPEtTQSLIQFVRTVRDyinrspGAGPTVVHCSAGVGRTGTFIALDRILQQlds
                              .||. ...|. |||||||. ...|..|...|..        ||..||||||||||||..|.. ....   
..............................erlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaaylmkkl...

kdSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARK
  .|... ||. .| .| .||.|. ||..|.......|. .|
..gvsleeavklvrsrRpgmvitpnqyfflqlallellllkk
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1945-2191 3.4e-38 126.1 In-house 48-296 (305) alignment 
Range on Protein: 1945-2191
Range on HMM: 48-296/305.0
NRGKNRYNNILPYDATRVKLsnvDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPAD-QDSLYY
..||||| ..   |  ||||   .     .|| | |.      . .| || ||  |  ||| | ....|..| |. . .|||  || .|.... .| | .
eagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlef

GD----LILQMLSESVL-----PEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRdyinrsPGAGPTVVHCSAGVGRTGTFIA
 .    ..... | . |      . ...| ..  |      | . |.|.  ||| ||| . .......   |      |  ||.|||||||.||||. . 
eekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekar......pskgpivvhcsagigrtgsvvm

LDRILQQLDSKDSVDIY-GAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQ
|. ||.|| . . ..     .  .|  |   .||. ||...|| . . .| .||  |.
leyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkklldee
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1945-2036 5.7e-24 79.5 In-house 47-152 (350) alignment 
Range on Protein: 1945-2036
Range on HMM: 47-152/350.0
NRGKNRYNNILPYDATRVKLSNVD--------DDPCSDYINASYIPGN------NFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKC
   ||||.|||||. .|||| .              .|||||.|.  .      |    || ||.||| | |||.|.. . .|. |...|. || .. ||
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

DHYWPA
..||. 
yrYWqe
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1945-2021 3e-13 44.0 In-house 37-118 (347) alignment 
Range on Protein: 1945-2021
Range on HMM: 37-118/347.0
NRGKNRYNNILPYDATRVKLS-----NVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQ
.  ||| ..    ||||| ||     |   |.   |||||.|  .| ..|||.|| ||| |  ||||||   .| ..| . .
slsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1945-2030 2e-06 21.5 In-house 34-118 (332) alignment 
Range on Protein: 1945-2030
Range on HMM: 34-118/332.0
NRGKNRYNNILPYDATRVKLSNVDddPCSDYINASYIPGNNFRREYIVTQGPLPG-TKDDFWKMVWEQNVHNIVMVTQCVEKGRVKC
|   ||   .  .| .||.|.  |     |. |||.. | . .  ||..| |.   |.  ||.|| |..   |... .  || . |.
nmdmnriphlycfdhsrvelapqd..gkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1946-2036 5.7e-15 49.5 In-house 49-155 (349) alignment 
Range on Protein: 1946-2036
Range on HMM: 49-155/349.0
RGKNRYNNILPYDATRVKLSNV------------DDDPC--SDYINASYIPGNNF--RREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVK
  ||||..||||. .|||| .             . | .   ||||| |.   ..   . || || ||| | |||.|..  ..|. .. ...  |..  |
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

CDHYWPA
|| ||  
cdiywqe
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1947-2178 2.6e-17 57.9 In-house 21-255 (290) alignment 
Range on Protein: 1947-2178
Range on HMM: 21-255/290.0
GKNRYNNILpYDATRVKLSNVDDDPCSDYINASYIPGNNFrREYIVTQGPLPGT-------KDDFWKMVWEQNVHNIVMVTQCVEKGRV----KCDHYWP
 ..|... |   |||| | .      .||| |...   |   . |.|| |.  .         .|| |. . .|...||. .  || .      | .| |
mdqRlevpL.veatrvvLkgygkrfnddyiHAnrvtcpng.lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvp

ADQD-SLYYGDLILQMLSESVLPEWTIREFKICGEEQLDahRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYinrspgAGPTVVHCSAGVGRTGTFIA
   . .| ...| ..  |     .  .||  .  ... .    . |  .  | .  |.|.|..|.. ...|. .        | .|||  |. |  .. |
esvgeelkfkgltvkCkskekeddvetRelvvkfddeee..ftvtHsllkgWnklnvqedtktllsliqkvkas......ktpvivHcvdGiSrsAalaa

LDRILQQLD-SKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV
..   | .  ...|| .  ....|| .| ...... .. .    .
iilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagi
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1955-2091 6.6e-12 39.9 In-house 3-126 (130) alignment 
Range on Protein: 1955-2091
Range on HMM: 3-126/130.0
LPYDATRVKlsnvdddpCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVhNIVMVTQCVEKGrvkcDHYWPADQDSLYYGDLILQMLSES
|... .|..          .|||||..   .  .||. || ||  |  |||||. |. | |...|   ||.     | |||  .   .| . |.  |.. 
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryv.nvlvvlgsveee....deywpdsePlewyeediivtltdr

VLPEwTIREFKICGEEQLDA-HRLIRHFHYTVWPDHGV
   .  |.  .. .|..|   |. .  |. . ||  | 
defk.nikasnleiesdlneshqaltmfqisnwpsdgt
0044763 (Phosphotyrosine protein) phosphatases II 1956-2180 1.1e-40 134.5 In-house 1-169 (178) alignment 
Range on Protein: 1956-2180
Range on HMM: 1-169/178.0
PYDATRVKLSNVDDDPCSDYINASYIPGNnfrreYIVTQGPLpgtkDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDslyygdlilqmlsesv
|.| |||.|||. . ..|||||||.| ..     ..... |      |......|.... ||..|. .| |..|||.||| . .                
pldrtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag................

lpewtirefkicgeeqldahrliRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPgaGPTVVHCSAGVGRTGTFIALDRILQQldskdSVDIYGAVH
                        ..... .||||||. .. . .||. .........  ||..|||||||||.||..|.. ....     ..... |..
.......................iqylhipipDhgvpdllehflefvefieealdekg..gpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaie

DLRLHRVhMVQTECQYVYLHQCVRD
 .| .|  .|... |. .|... . 
lvrerRp.ivpnpgqlrqLyefelr
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1967-2173 3.2e-18 60.7 In-house 16-212 (255) alignment 
Range on Protein: 1967-2173
Range on HMM: 16-212/255.0
VDDDPCSDYINASYIPgnNFRREYIVtqgplpgTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDS-LYYGDLILQMLSesVLPEWTIREFK
.|.| |.. .. .  .  . .  |..       | | |....  .. ...||..   |.|..||..|.| ..|  | . |. .         .  .|  .
idedvctehvkPekdk..krknlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtle

I---CGEeQLDAHrLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYinRspgagPTVVHCSAGVGRTGTFIALDRILQ----QLDSKDSVDI--YGAVHD
|    || .  .|  ..|..|. |...  || .. . . .. |||   .     . |||||.|.||. .|.  . . |    .||  . |..     ...
itstlge.kkkth.tvkhysykGWieknaPelareilnilkvvrds..k.....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylsllee

LRLHRVHMVQTECQYVY
|| .|   ..|  |  .
lrskrkraihtPlqlaf
subfamily_hpo-7_pd Subfamily hpo-7 1967-2173 2.4e-15 51.1 In-house 19-218 (263) alignment 
Range on Protein: 1967-2173
Range on HMM: 19-218/263.0
VDDDPCSDYINASYIPgnNFRREYIVtqgpLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDS-LYYGDLILqmLSESVLPEWTIREFK
.|.| |.. .. .  .  . .  |..    |  | | |....  .. ...||..   |.|..||..|.| ..|  . . .. .   .  |  .  ..  .
idedvctehfkPekdk..krknlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnv..cttkvqsdvllktle

ICG--EEQLDAHRlIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYinRSpgagpTVVHCSAGVGRTGTFIALDRILQ----QLDSKDSVDI--YGAVHDL
.    .|.   |  ..|. |. |...  || ... .. .. .|.   .|      |||||.|.||.  |   . . |    .||  . |..     ...|
llstlgeKkktht.vkhysykgWiekndpelareilnilkvarns..ks.....lvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleel

RLHRVHMVQTECQYVY
| .|   ..|  |  .
rssrkraihtPmqLaf
0046846 (Phosphotyrosine protein) phosphatases II 1968-2179 3.2e-47 155.8 In-house 7-170 (176) alignment 
Range on Protein: 1968-2179
Range on HMM: 7-170/176.0
DDDPCSDYINASYIPGNnfrrEYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYygdlilqmlsesvlpewtirefkic
 .|...|||||..| |.     .|.||||||.|  ||..|..|.... .|..|..||.||.||..|||  ..  .                         
gldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.........................

geeqldahrlirHFHYTVWPDHGVPETtQSLIQFVRTVRDYINRSpgaGPTVVHCSAGVGRTGTFIALDRILQqldsKDSVDIYGAVHDLRLHRV-HMVQ
            ..... |||||||.  . |..... .|.....    ||..||||||.|||||..|.. .      .  .... |.. .| .|  ..||
............qylhlpwpDhgvpdl.elllellefirealkeg...gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavq

TECQYVYLHQCVR
|..|| .|.....
tpeQyrflyefel
0043147 (Phosphotyrosine protein) phosphatases II 1970-2177 2.2e-47 156.3 In-house 2-156 (172) alignment 
Range on Protein: 1970-2177
Range on HMM: 2-156/172.0
DPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCvekgrvkcdhywpadqdslyygdlilqmlsesvlpewtirefkicGE
|. ||||||||....   ...|.|||||. | .|||.|..|.... ||..|..                                               
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.............................................ly

EQLDAHRLIRHFHYTVWPDHGVPeTTQSLIQFVRTVRDYINRSPGaGPTVVHCSAGVGRTGTFIALDRILqqldskDSVDIYGAVHDLRLHRVHMVQTEC
   . .||. ...|. ||||||| ... |..|.. .......||| ||..||||||||||||..|.. .|       ..... ||. .| .| ..||.. 
dpellerlgiqylylpwpDhgvp.llellleflefidellalspg.gpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnps

QYVYLHQC
|| .|...
qyrflyyf
0051429 (Phosphotyrosine protein) phosphatases II 1971-2185 2.8e-57 189.7 In-house 2-228 (272) alignment 
Range on Protein: 1971-2185
Range on HMM: 2-228/272.0
PCSDYINASYIPGNnF----RREYIVTQGPLPGTKDDFWKMvWEQNVHNIVMVTQCVEKGRVKCDHYWP-----------ADQDSLYYGDLILQMLSESV
| |.||||....|. .    .. .. ..|||| | .|||.. .|.... ||......|.||.||| |||            .  .  ||.| . .|||..
plsgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

LPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTqsLIQFVRTVRDyinrspgAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVD------
|. ...||. .  . . .. | ..|.||| |||||||. .  |..... ..|        || .||||||..||||..||...|....  . ||      
lldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltn

--IYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRAR
  ...||. || .| ..|||| ||..|.......||. 
lyleeaveelraqrpgavqteeqylflyeallellrsl
0051082 (Phosphotyrosine protein) phosphatases II 1972-2177 2.4e-37 123.2 In-house 2-148 (151) alignment 
Range on Protein: 1972-2177
Range on HMM: 2-148/151.0
CSDYINASYIPGNnfrreYIVTQGPLPgtkdDFWKMVWEQNVHNIVMVTQCVEKGrvKCDHYWPADQdslyygdlilqmlsesvlpewtirefkicgeeq
 |||||.||. |.     .....|||.    ||.....|...  ||.... .| |  .| .|.|. .                                 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

ldahRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDyinrsPGAGPTVVHCSAGVGRTGTFIALDRILQQldskdsVDIYGAVHDLRLHRVHMVQTECQY
    . ..|.... |||.|.|........|.. ..|     .. ||..||||||.|||||..||...|..      |... |....||.| ..||.. |.
....ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqf

VYLHQC
......
lfqlfa
0036282 (Phosphotyrosine protein) phosphatases II 1973-2176 1.6e-50 166.5 In-house 2-164 (174) alignment 
Range on Protein: 1973-2176
Range on HMM: 2-164/174.0
SDYINASYIPGNNFRREYIVTQGPLPgtkddFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPAdqdslyygdlilqmlsesvlpewtirefkicgeEQL
|||||||.. ..   ...|..||||.     ||.|..|.... .||.....|.|..|| .|||                                   . 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lre

DAHRLIRHFHYTVWPDHGVPETTQsLIQFVRTVRDYINRsPGAGPTVVHCSAGVGRTGTFIALDRILQQLDsKDSVDIYGAVHDLRLHRVHMVQTECQYV
| .||. ...|. |||||||.... |..||. |...... .. ||..||||||||||||..|....|..|   . ||..  |. |||.| .||||. || 
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyr

YLHQ
.|..
flyy
0049260 (Phosphotyrosine protein) phosphatases II 1980-2176 4.9e-43 141.8 In-house 1-144 (152) alignment 
Range on Protein: 1980-2176
Range on HMM: 1-144/152.0
YIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWpadqdslyygdlilqmlsesvlpewtirefkicgeeqldahrlir
.|.| .  .|.| ||||.| | .|||.|..|.... |||.|...|.|..||..|.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

HFHYTVWPDHGVPETTQSLIQFVRTVRDYinRSPGAGPTVVHCSAGVGRTGTFIALDRILqqldskDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQ
..... |||||||. .| |..... .. .  .    ||..||||||||||||..|.. .|        |... ||  .| .| ..|... |. .|..
qylhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1987-2176 9.6e-22 72.1 In-house 3-197 (198) alignment 
Range on Protein: 1987-2176
Range on HMM: 3-197/198.0
RREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQD-SLYYGDLILQMLSESVLPEWTIREFKICGEEQ-LDAHRLIRHFHYT
.| ||.|| ||  |  |||.||||     |||| .   .  .    |||. .  .  || | .   . .. |..||  . .. .     . | | |. .|
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

VWPDHGVPETTqSLIQFVRTVRDYINRS--PGAGPTVVHCSAGVGRTGTFIALDRILQ-QLDSKDS-VDIYGAVHDLRLHRVHMVQTECQYVYLHQ
 | ..  |. .  .. || . |.  ..       | .|||| | | || |.|||  .. . .|| | ||..   . ||  |. .. .  .| ...|
swkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1987-2176 9.7e-22 72.1 In-house 4-198 (199) alignment 
Range on Protein: 1987-2176
Range on HMM: 4-198/199.0
RREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQD-SLYYGDLILQMLSESVLPEWTIREFKICGEEQ-LDAHRLIRHFHYT
.| ||.|| ||  |  |||.||||     |||| .   .  .    |||. .  .  || | .   . .. |..||  . .. .     . | | |. .|
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

VWPDHGVPETTqSLIQFVRTVRDYINRS--PGAGPTVVHCSAGVGRTGTFIALDRILQ-QLDSKDS-VDIYGAVHDLRLHRVHMVQTECQYVYLHQ
 | ..  |. .  .. || . |.  ..       | .|||| | | || |.|||  .. . .|| | ||..   . ||  |. .. .  .| ...|
swkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1988-2046 7.2e-07 22.9 In-house 236-291 (440) alignment 
Range on Protein: 1988-2046
Range on HMM: 236-291/440.0
REYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKgrvKCDHYWPADQDSLYYGDL
  .| || ||  |  |||..| . ..  |.|. |  .|    |  ||| .  |. .| .
nafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpf
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1989-2090 2.5e-08 27.8 In-house 138-234 (244) alignment 
Range on Protein: 1989-2090
Range on HMM: 138-234/244.0
EYIVTQGPLPGTKDDFWKMVWEQNVhNIVMVTQCVEKGrvkcDHYWPADQDSLYYGDLILQMLSE-SVLPEWTIREFKICGeEQLDAHRLIRHFHYTVWP
|||.|| ||  |  |||||. |. | |...|   ||.     | |||  .   .| . |   |..   . .    ...|   .  ..|. .  |  . ||
eyiltqhpladtsmdfwkmmlerhv.nvlvvlgsveee....deywpdseplewyeeditvtltdrdefknikasnleies.dmneshqaltmfqisnwp

DHG
  |
sdg
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1996-2182 1.8e-18 61.0 In-house 99-288 (302) alignment 
Range on Protein: 1996-2182
Range on HMM: 99-288/302.0
PLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPAD-QDSLYYGDLILQMLS-ESVLPEWTIR-EFKICGEE------QLDAHRLIRHFHYTVW
|   |.. .| .. . ||  .| ... ||..  || .|.  . .. | .|   .. .| .  | |.| . .||.   |      . . .. .  .... |
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDHGVPETTQSLIQFVRTVRDYINRspgagpTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVL
|||| |. ... .. ..    | .        .||||||||||||..|.   .|    |.  |.   |  .|  |   ||.| | .||  ||   |
pdhGapkeaytaldilkfcesykkn......vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkgl
0048076 (Phosphotyrosine protein) phosphatases II 2039-2180 2e-28 94.3 In-house 9-141 (145) alignment 
Range on Protein: 2039-2180
Range on HMM: 9-141/145.0
DSLYYGDLIlQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSpgaGPTVVHCSAGVGRTGTFIALDRI
..||.|.|    |.   | .. |.    .  |. .  ||. ...|. |||||||. .. |..|.. .......    ||..||||||||||||..|.. .
pglylgslp.taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg...gpvlVHCsaGvgRtgtlvaaylm

LQqldskDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRD
|.      .|... |.. .| .| ..|... |. .|..... 
ll.....lgvsleealelvrsqrpgavpnpgqlrflyefele
subfamily_PTEN_pd Subfamily PTEN 2048-2174 1.2e-08 30.1 In-house 51-172 (184) alignment 
Range on Protein: 2048-2174
Range on HMM: 51-172/184.0
LQMLSESVLPEWTIreFKICGEEQLDAHRLIRHFHYTVWPDHGVPEtTQSLIQFVRTVRDYINRSPgAGPTVVHCSAGVGRTGTFIAL--DRILQQLDSK
 ..| ..   .. |  . ...|.. |....  . . .   ||  |.  . | ..|...........     |||| || ||||. |.     .|.  ...
vkflekkhkdhyki..ynlrserkydskkfdgrvavypfdDhnppp.lelleeivediekwleedk.knvvvvHCkaGkGRtGvlivayllkslllekae

DSVDIYGavhDLRLHRVHMVQTECQYVYL
......      | .  . |.   |  |.
ealelfa...eaRtknkkgvtiPsqrRYv
subfamily_VSP_pd Subfamily VSP 2064-2175 2.3e-07 25.0 In-house 79-192 (212) alignment 
Range on Protein: 2064-2175
Range on HMM: 79-192/212.0
FKICGEEQLDAHRLIRHFHYTVWPDHGVPETtQSLIQFVRTVRDYINRSPGAgPTVVHCSAGVGRTGTFIALDRILQ--QLDSKDSVDIYGAVHDL--RL
. .| | . | . . .. .     || ||.  . |..| ..|...... .     ..||  | ||||| .    .       .|.|.| .|       . 
vnlcseraydekyfnnrvkriliddhnvpkl.eellvftkevkewlekdlkn.vlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdkteg

HRVHMVQTECQYVYLH
..   |||  |. |..
ekfqGvqtpsqkryvg
0048179 (Phosphotyrosine protein) phosphatases II 2069-2177 2e-26 87.8 In-house 40-140 (144) alignment 
Range on Protein: 2069-2177
Range on HMM: 40-140/144.0
EEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINrsPGaGPTVVHCSAGVGRTGTFIALDRILqqldsKDSVDIYGAVHDLRLHRVHMVQTE
 |. .  | . ..... |||||||. .. |..|.. ......  .| ||..||||||||||||..|.....     |  .... |.. .| .| ..|...
yepefleregiqylhlpwpDhgvpdllellleflefieeale..eg.gpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnp

CQYVYLHQC
 |. .|...
gqlrfLley
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2076-2182 6.2e-22 72.5 In-house 89-194 (440) alignment 
Range on Protein: 2076-2182
Range on HMM: 89-194/440.0
RLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSpGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLH
| ....||  |||.|||. .  ...... | .  ... | || .||||||.||||  ||.| ||..    | .||.  .  .|  | .||||  ||...|
rtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqeka.gngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

QCVRDVL
..| . |
eavlegl
PTPc_DSPc_SM00012 2078-2178 4.2e-35 115.5 In-house 2-103 (105) alignment 
Range on Protein: 2078-2178
Range on HMM: 2-103/105.0
IRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSK-DSVDIYGAVHDLRLHRVHMVQTECQYVYLHQ
..|.||| ||||||||...|.....| |..  | |  ..|.||||||||||||||.||| .||||... ..|||.  |. || .| .||||| ||..|..
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

CV
..
al
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 2078-2181 1.2e-13 45.6 In-house 217-343 (350) alignment 
Range on Protein: 2078-2181
Range on HMM: 217-343/350.0
IRHFHYTVWPDHGVPETTQSLIQFVR---------TVRDYINRSpGAGPTVVHCSAGVGRTGTFIALDRILQ---QLD--SKDSV----------DIYGA
. ....  |.| ..    .|..| .          . . ... .  . | .||||||||||||...|| .|.    |.   |.|.           |   
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldna.rsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

VHDLRLHRVHMVQTECQYVYLHQCVRDV
|  ||  |. |||.  |.........  
vnelrkqrismvqnldqfifiYeallfy
0038934 (Phosphotyrosine protein) phosphatases II 2080-2178 2.2e-12 42.5 In-house 81-173 (194) alignment 
Range on Protein: 2080-2178
Range on HMM: 81-173/194.0
HFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGaGPTVVHCSAGVGRTGTFIALDRILQqldskDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV
...   .||.|.. ... | .|.. | ...|..|| |  .||| ||.|||||..|   |          .   |.. .|  | .....  .. .|.. .
eylklpfpddgtvPsleillrfldlvdeflnedpg.gvvaVHCkaGlgRtGtlvaaYLiyr.....lgmsaeeAialfrekRpgaipnqdyleallkry
subfamily_PTPDC1_pd Subfamily PTPDC1 2081-2177 2.4e-07 25.4 In-house 85-171 (182) alignment 
Range on Protein: 2081-2177
Range on HMM: 85-171/182.0
FHYTVWPDHGVPeTTQSLIQFVRTVRDYINRspgaGPTVVHCSAGVGRTGTFIALDRILQQldskdSVDIYGAVHDLRLHRVHMVQTECQYVYLHQC
..   |.|.||. . ..... |. |   ...    | . ||| || ||||  ||   . ..     ...   |.. .| .| . .||  |   ... 
vynfgwkDygva.sleriLdivkvvafalqe....gkvavhChaGlGrtGvliacylvyak.....rltaekaiklvrskrpksiqtreqvelvkef
PTEN_1 2082-2134 3.1e-08 28.7 In-house 98-149 (196) alignment 
Range on Protein: 2082-2134
Range on HMM: 98-149/196.0
HYTVWPDHGVPEtTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIA
.   ..|||.|   ..|. ... . ... . |  .  .||| ||.||.|| .|
lhfpieDhgaps.lselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 2083-2178 4.5e-08 26.8 In-house 225-340 (349) alignment 
Range on Protein: 2083-2178
Range on HMM: 225-340/349.0
YTVWPDHGVPETTQSLIQFVRTVRDYINR--------SPGAGPTVVHCSAGVGRTGTFIALDRILQ--QLDSKDSVD----------IYGAVHDLRLHRV
.  |.| ..    .|..| .    | |.         .    . .|||||| ||||... || .|.  .  ...|.           |. .|  ||  |.
vknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqri

HMVQTECQYVYLHQCV
 |||   |.. .....
smvqnlaqfiaiyeal
subfamily_eak_pd Subfamily eak 2101-2188 5.4e-07 23.3 In-house 223-311 (332) alignment 
Range on Protein: 2101-2188
Range on HMM: 223-311/332.0
FVRTVRDYINRSPGAGPtVVHCSAGVGRTGTFIALDRILQQLDSK--DSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLR
.  |.. ||   |   | .. .. |  |.|.|. .| ... .|.|  ..  .   .   . .|.| | .. |. .... | | |. |. |
lsstlkkyihtppsfap.iiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnr
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 2111-2179 1.5e-09 32.1 In-house 224-292 (297) alignment 
Range on Protein: 2111-2179
Range on HMM: 224-292/297.0
RSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVR
  |   ...|||||||||.|  .  | ||..|  |   |.   .. ||  |  .|||  |. .|.. | 
emprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavl
subfamily_CG42327_pd Subfamily CG42327 2115-2178 8.3e-14 46.0 In-house 247-311 (319) alignment 
Range on Protein: 2115-2178
Range on HMM: 247-311/319.0
AGPTVVHCSAGVGRTGTFIALDRILQQLDS-KDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV
 || ||||| ||||||. || |  ...|.  | ||||   |. .|  | . |.|  || .... .
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 2119-2183 1.6e-13 44.8 In-house 2-66 (69) alignment 
Range on Protein: 2119-2183
Range on HMM: 2-66/69.0
VVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLR
|||||.| ||||||||.   . .. |.  |||.  |  .|  |  ||  | .|...|  . . |.
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealk
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 2119-2184 4.8e-13 43.2 In-house 1-66 (69) alignment 
Range on Protein: 2119-2184
Range on HMM: 1-66/69.0
VVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRA
|||||.| ||||||||.   . .. |.  |||.  |  .|  |  ||  | .|...|. . . |. 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealkl