Gene PTPRJ in Homo sapiens

Synonym: CD148, DEP1, HPTPeta, R-PTP-ETA, SCC1, PTPRJ

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRB
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP092_AA protein Get Run
HsapP092_AA_1023-1300 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
fn3 Fibronectin type III domain 120-187 5.7e-08 26.0 Pfam-A 1-74 (85) alignment 
Range on Protein: 120-187
Range on HMM: 1-74/85.0
SPVFDIKAVSISPTNVILTWKSN---DTAASEYKYVVKHKMEN--EKTITVVHQP-WCNITGLRPATSYVFSIT
|.. .... ....|.. |.|.     .   . |.  ...| ..  .|..||  .   ...|||.| |.|.|...
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVq
fn3 Fibronectin type III domain 369-437 3.8e-08 26.5 Pfam-A 3-76 (85) alignment 
Range on Protein: 369-437
Range on HMM: 3-76/85.0
VFDVTAVNISATSLTLIWKVSDNESSSNYTYKIHVA--GETD-SSNLNVSEPR--AVIPGLRSSTFYNITVCPV
. .... ....||||| |. ... ..    |.....  |... . . .|...   ....||. .| |...|  |
PenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqav
fn3 Fibronectin type III domain 541-606 1.9e-07 24.3 Pfam-A 1-73 (85) alignment 
Range on Protein: 541-606
Range on HMM: 1-73/85.0
SAVFDIHVVYVTTTEMWLDWKSP-DGASEYVYHLV-IESK-HGS--NHTSTYDKA--ITLQGLIPGTLYNITI
||. ...|  ||.|.. | |. | || .....  |  ..| .|.  .. ..   .   ||.|| ||| |....
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrV
fn3 Fibronectin type III domain 626-704 1e-07 25.2 Pfam-A 3-80 (85) alignment 
Range on Protein: 626-704
Range on HMM: 3-80/85.0
PSNVSNIDVstNTTAATLSWQNF-DDASPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDG
|.|.| ..|  ..| .||||.   |. .|  .| .  ...|...  ... ..   | .|.|.| ||..|.... |. |.|
Penlsvsev..tstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngag
subfamily_PTPRA_pd Subfamily PTPRA 1014-1328 4.1e-91 300.3 In-house 7-323 (330) alignment 
Range on Protein: 1014-1328
Range on HMM: 7-323/330.0
KPKKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQ-THSTDDYINANYMPGYHSKKDFIAT
 .||   . ||..|   ....|| |  | ||.. |    |     .|.  ||. |||. |.|||| ||| |||.  . . ||||| .. ||. |. |||.
gnkkyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaa

QGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVK----NIQTSESHPLRQFHFTSWPDHGV
|||. .|..|||||.||..  .|.|||.  |. ..||. |||.. .  ||.|.|..  | || ..|.|.| |.    . .  .|  .|||||||||| ||
qGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGv

PDTTDLLINFRYLVRDYMKQSPPesPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRsQKDSKVD
| ..  ....   |.   .||    || ||||||||||||||..| .. ... |. |||...|  ||. || ||||. ||.|. . .|.      |...|
PfepiGmlkllkkvkklnqqsag..pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyl.ygdteld

LIYQNTTAMTIYENLAPVTT
..  ..   ..|.... .. 
vsslekhlqklynkitgtdk
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1014-1303 3.4e-72 238.1 In-house 3-288 (297) alignment 
Range on Protein: 1014-1303
Range on HMM: 3-288/297.0
KPKKSKLIRVENFEAYFKKQQadSNCGFAEEYEDLKLVGIsQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHS-TDDYINANYMPGYHSkkDFIAT
.||. . | . .| .. .|..  .   | ||. .|    | ||.  ||   |  |.||.|.|||| ||||| .  ..   ||.|| ...|..    .|.|
spkerrpiplsdfatlvqknr..htdvfseeflclpeani.qpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlitt

QGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRtKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPD--
| | ..|..|||.||....| .|.||..  |. . ||  ||. |  . .||..| ..|         |...|.. ..   . ..|..|..|||. |.   
qmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkd

TTDLLINFRYLVRDYMKQSPpESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQK
..  |...   ||.  .|   |.|.||||.||||||| ...||  . ....|..||..|.|  || .|| .|||..|| |. . ||. . |..
sassllklisevrkdfsqna.egPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsed
subfamily_PTPRB_pd Subfamily PTPRB 1016-1305 1.9e-131 432.5 In-house 2-291 (293) alignment 
Range on Protein: 1016-1305
Range on HMM: 2-291/293.0
KKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKL-SVQTHSTDDYINANYMPGYHSKKDFIATQG
|||| |..|.||...||..|||...|.||||.||.|| .| . |||||.|| ||||.|.|||| ||||| .....|..|||||||.|||.|...||||||
kkskpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqG

PLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSK-QAQDYGDITVAMTSEIVLPEWTIRDFTVKNiqTSESHPLRQFHFTSWPDHGVPDTTD
|||.|..|||||||||.. .|.|||..||.|..|||||||.. ... ||||.| ...| .| .|.||......  ..|.. .||.|||||||||||..|.
PlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektk

LLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDS
 |..| . ||......  ..||.|||||||||||||||.|||. .||.|..||..|||..||..| |.||||.||.|..|||||..|.....
tlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkkeee
0050432 (Phosphotyrosine protein) phosphatases II 1016-1300 1e-105 348.7 In-house 21-300 (308) alignment 
Range on Protein: 1016-1300
Range on HMM: 21-300/308.0
KKSKLIRVENFEAYFKKqqADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLsvqtHSTDDYINANYMPGY--HSKKDFIATQ
..|. ..|...  ...|  |... .. ||.|.|  | .. . ..|.| ||. |||| ..|||| |||||    ....|||||.|..||  .... |||||
vsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsyvdgyssklprkfIatq

GPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSK---QAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPD
||||||..|||||||| ||  |.||||.|| || ||..|||..   . . ||..|| ..|| ||...|.| ....|....||. ...||.|.|||||||.
gPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPp

TTDLLINFRYLVRDYMkqspPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVR
 .. |..|  |||...    |..||.|||||||||||||||.| |. |.| |..|||...|. ||..|| ||||..||.|| ...|....
speilldflelvrksl....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk
0039614 (Phosphotyrosine protein) phosphatases II 1016-1300 7.2e-99 326.2 In-house 9-290 (297) alignment 
Range on Protein: 1016-1300
Range on HMM: 9-290/297.0
KKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISqpKYAAELAENRGKNRYNNVLPYDISRVKLSVQTH--STDDYINANYMPGYHS-KKDFIAT
..| .|... ....... .|.|. .. .|.|.|. . ..  .. |.| ||. |||| ..|||| |||||..  .    .|||||.|..||.  ...||||
lesipiplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIat

QGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRtKCEEYWPSKQAqDYGDITVAMTSEIVLPEWTIRDFTVKNiqTSESHPLRQFHFTSWPDHGVPDTT
|||||.|..|||||||| .| .|.||||.|| || ||..|||...   |||.|| ......|. .|.| ..|.|  ..||. ...|..|.|||||||...
qgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppsl

DLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVR
.||..|  |||......|.. |.||||||||||||||||......|.| | .|||. .|  ||..|| .|||..||.|| ...|. ..
ellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk
0045450 (Phosphotyrosine protein) phosphatases II 1016-1298 1.5e-97 322.3 In-house 4-303 (307) alignment 
Range on Protein: 1016-1298
Range on HMM: 4-303/307.0
KKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGI--SQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTH--STDDYINANYM--------PGY
. |..|...... .......|.. |...|.|.|. | .  . . ..|.| ||. |||| ..|||| .|||||. ..  ...|||||.|.        .||
plslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgy

HSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSK-QAQDYGDITVAMTSEIVLPEWTIRDFTVKNI-QTSESHPLRQFHFT
..|. |||||||||.|..|||||.||..| .|.|||..|| || || .|||.. . . ||..|| ..|| .|...|.| ..|..  .|.||. ...||.|
dlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhyt

SWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENT---VDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDI
.|||||||.... |..|  .||......|...|.||||||||||||||||.. ...|.|.|.|   ||.. .|  ||..|| .||...||.|| ...|. 
gwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
subfamily_PTPRD_pd Subfamily PTPRD 1018-1304 1.4e-115 382.1 In-house 2-286 (564) alignment 
Range on Protein: 1018-1304
Range on HMM: 2-286/564.0
SKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVgISQPKYAAELAENRGKNRYNNVLPYDISRVKL-SVQTHSTDDYINANYMPGYHSKKDFIATQGPL
|| | |........| .|.|.  | |||....    . .. ||.  .|. ||||.|...|| |||.| .|. ..  |||||... ||...| .|||||||
skpipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPl

PNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLI
..|..||||||||.|.  |.||||..|.|..||..|||.|. . ||..|| ...|  | . .||.|..|. ..|||.  ||||||||||||||...  |.
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslL

NFRYLVRDYMkQsPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKD
...  ||..  . | . ||.||||||||||||||.|| .. .|..|.|||.|..|  || .|. |||||.||.|. . .|. . ....
dlirkvraln.e.pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnt
0051299 (Phosphotyrosine protein) phosphatases II 1019-1298 3.6e-105 346.8 In-house 3-285 (288) alignment 
Range on Protein: 1019-1298
Range on HMM: 3-285/288.0
KLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTH-STDDYINANYMPGYHSKKDFIATQGPLP
. |.||... ...| .|....|..||.|.|  . .. . .|| | ||. |||| ..|||| |||||||    ...|||||.|..||..|. |||||||||
teisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlp

NTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNI----QTSESHPLRQFHFTSWPDHGVPDTTD
||..||||||||.||  |.||||.|| ||.||. |||... . |||||| ..|| ||...|.| ..|.|.    ...||.  ..||.|.||||||||...
ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspe

LLINFRYLVRDYMKqsPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDI
||..|  |||....  ....|..|||||||||||||||.| |..|.|.|..|||...|  ||..|| ||||..||.|. ...|. 
llldflrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1019-1305 5.3e-85 280.2 In-house 2-289 (305) alignment 
Range on Protein: 1019-1305
Range on HMM: 2-289/305.0
KLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVgiSQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHST-DDYINANYMPGYHSKKDFIATQGPLP
| | .....|| |.....|. |. ..|. |     ...    .  .|. |||.... ..| .|..|. . .    |||||.|. ||..|| .|..||||.
kiialddlaayikearvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlk

NTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQ--DYGDITVAMTSEIVLPEWTIRDFTVKN-IQTSESHPLRQFHFTSWPDHGVPDTTDL
||..||||...|  |  |.|||| ||.|. ||. ||| ....  ..|...| ..||   .....|.... .  . .||. . |...|.|||||||...  
ntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfats

LINFRYLVRDYMKQSpPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDS
|...   |.   |..  . |.||||||||||||.|||.|  . ....|..|||....  || .|. |||| |||||| . . . . . . |
llslikrvqkdqkkd.kgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdts
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1019-1114 7.5e-12 39.3 In-house 3-95 (95) alignment 
Range on Protein: 1019-1114
Range on HMM: 3-95/95.0
KLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVgiSQPKYAAELA-ENRGKNRYNNVLPYDISRVKLSvqTHSTDDYINANYMPGYHSKKDFIATQG
| | |  | ..  . ...|.  | .|.  . .   |   |..  .  |  |||. |..||| .|| |.  |.   ||||| .. ||  |. .||.||
kpihvsvfhshvlemhsnsdqefdnefksismt..sgapytvgsseanipknrflnifpydatrvvlt..tkrdsdyinacfvdgyarkncyiaaqg
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1020-1303 2.3e-74 245.0 In-house 1-282 (287) alignment 
Range on Protein: 1020-1303
Range on HMM: 1-282/287.0
LIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELA-ENRGKNRYNNVLPYDISRVKLSvqtHSTDDYINANYMPGYHSKKDFIATQGPLPN
|| ||.|  . .|..| .| || . .  |. |. .. .   ..| .|. |||....|..|  || |       .||||| .. ||..|| ||....|. |
lipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk...gehpdyinavfidgykekkafiiaesPmfn

TLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQ-TSESHPLRQFHFTSWPDHG-VPDTTDLLI
|...||......|| ||.||..  |. . .| .|||....  .|. ......| |  ....|.. ||| . ... . ..|...|.|...| |..    |.
tarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtill

NFRYLVRDYMKQSppESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQK
 .   ..   |..  ...|.||||..|||...|.|..  | . ..| ..||. ..   |. .| .||| .|| |.|. ||  . | .
vieemyktqrkrg..ntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfe
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1020-1301 5.2e-74 243.7 In-house 1-285 (290) alignment 
Range on Protein: 1020-1301
Range on HMM: 1-285/290.0
LIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHS---TDDYINANYMPGYHSKKDFIATQGPL
||.|..|  .  ...|  | || .... |.    ..  . .   .|. .||..|...||  |. |   .     |..|||| |. ||. ||..||||||.
lipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpv

PNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQT-SESHPLRQFHFTSWPDHG-VPDTTDL
.|||.|||...|...| .|.|||. .|.|..||  |||......|| ... ...| .| | ..| . ||| ..  ... . |...|.|...| |....  
sntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqti

LINFRYLVRDYMKQSppESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRS
|. ..  ..   |.   . .|.||||..|||...|.|..  | . . |  .||. ... .|. .| .|||..|| ...| ||  . |
llvieemyktqrkrg..ntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1021-1303 3.8e-105 346.5 In-house 2-284 (318) alignment 
Range on Protein: 1021-1303
Range on HMM: 2-284/318.0
IRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQT-HSTDDYINANYMPGYHSKKDFIATQGPLPNT
| ||..|   .. ... .  . |||| |. .  .  .. .    |. ||||.|.|.|| .||||. .. . . |||||||..||..|| .||.|.|||.|
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

LKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFR
..||||||||.|   |.|||...|.|..|.. |||||... ||...| ...|. | ....| |.|.. ...||   ||.|.|||||.|||. .  |... 
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlv

YLVRdYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQK
  |. ...|.. ..||.|||||||||||.|||.| |. .|..|..|||...|  || .|.|||||||||.|. . .|. . | .
rqvs.kaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgd
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1021-1307 1.3e-90 298.8 In-house 5-292 (319) alignment 
Range on Protein: 1021-1307
Range on HMM: 5-292/319.0
IRVENFEAYFKKQQADSNCGFAEEYEDLKLVGiSQPKYAAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLPNT
|.|.... ..|. .. .. ....|...||  . ..  . |.  ||. ||||.|.|.|| .||.|| ..     |||||... ||. .. |||||.|| ||
ievqeLkerlkalastgetllekefkllkeav.ndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlent

LKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVkNIQTSES--HPLRQFHFTSWPDHGVPDTTDLLIN
..||||||||.... ..|||| ||... |...|||... ..|| ..| . .|  | .. ||.... |...||     . .|..|.||||.||... .|..
iedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPekatslld

FRYLVRDYMKQsPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQK-DSKV
.   .|  ... . . || ||||||||||||||..|  . ....|...||. .|  ||. |..|||...|| |. . .|..| . . . .|
llkrirksrek.tqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteiev
subfamily_PTPRG_pd Subfamily PTPRG 1021-1305 1e-88 293.0 In-house 1-293 (563) alignment 
Range on Protein: 1021-1305
Range on HMM: 1-293/563.0
IRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQ--PKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHST--DDYINANYMPGYHSKKDFIATQGPL
. |..|. .  .  ||.. ||.||.|.|.   ||.  .  ...  ||. |||| |...|| ||||||  .      |||||||. ||. .|.||||||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

PNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSE------SHPLRQFHFTSWPDHGVPD
..|..|||||.||.||  |.|.|. ||.|| ||. |||. ....|| ..| ...| ||   |.| ...||..  .       .  ||.|.|.|||||||.
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe

TTdlLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDS
 .  | .  . ...   .     ||.||||||||||||.|..| |. ||..||.|.|.|..  .|..|. .||||.||.|| . .|....|... 
hs..lpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiaskete
subfamily_Ptp69D_pd Subfamily Ptp69D 1021-1310 6.6e-86 283.2 In-house 4-298 (307) alignment 
Range on Protein: 1021-1310
Range on HMM: 4-298/307.0
IRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLPNT
| ... |  .|... |.. |.|.||| |.   |..   ..|  ||  ||||... ..|  ||||. .. . . |||||... ||. ||.||| |.|. .|
iaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveat

LKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQ-----TSESHPLRQFHFTSWPDHGVPDTTDL
..|||||..|..|. |.||..  |. | ||. |||  . . |||| | . ||   ....||.. | ...       .|. . |.|.|.|.|  ||...  
igDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevarg

LINFRYLVRDYMKQSppESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVR-SQKDSKVDLI
|... . ||.  |..  .|||.|||||||||.|.|.|.| |. |...|..||.. .| ||| .|.|.||  .||||| . .||    .. | .|| .
llklieqvrelykln..rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1021-1311 7.4e-78 256.6 In-house 6-291 (315) alignment 
Range on Protein: 1021-1311
Range on HMM: 6-291/315.0
IRVENFEAYFKKQQADSNCGFAEEYEDLKlVGISQPKYAAELAENRGKNRYNNVLPYDISRVKL-SVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNT
| .... .|  ...| .. || ..|| .   |  .|   |   ||. |||| |...|| |||.|  .....  ||.|||...||  |. .||.|||....
ipldqlityvaqkkastkngfkqdyesip.ggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvas

LKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKqAQDYGDITVAMTSEIVLPEWTIRDFTVknIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFR
.|||||.|.|...  |.|||. ||. . |.|.||| |    || |||.. || |  |.|.| ..|  .  .. . . |.|.||||| |||  |  |.|. 
vkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtlsv..vfgdnirevvqlhytswpdmgvpkytiplmnli

YLVRDYMKQSPpeSPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDSKVDLIY
  |. . ..|   ..|.||||||||||||||..| .. |.| || .||| ..  .|  |  |||. .|| |. . .|. .     |  . .|
rtvkqhhtnsv..gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdly
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1021-1299 3.2e-74 244.6 In-house 3-277 (315) alignment 
Range on Protein: 1021-1299
Range on HMM: 3-277/315.0
IRVENFEAYFKKQQAdsNCGFAEEYEDLKLVGISQPKYAAElAENRGKNRYNNVLPYDISRVKL-SVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNT
| | .| |. .|..    . |.||. ||    |.. . | |  .|  ||||.|.||.| .||||  .. .  .||||| |...... | .||.||||. .
ipvaqfpafvnknrh..talfseefhdlpdPdiyrqrvare.tinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkas

LKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQA--QDYGDITVAMTSEIVLPEWTIRDFTVKNiqTSESHPLRQFHFTSWPDHGVPDTTDLLIN
..||||||....| .|.|.||  |. . ||  ||| ..|   ..| | |.. |     . ..| .....  . ||. . ||.|| |||.||.  |  |..
vddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrk..seesrtvtqfqftewPdkGvdkqtssllk

FRYLVRDYmkQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIV
.   |.    . . | ..|||||||||||| .|.||  . ||.....|||. .|  || .|| .||||..| |. . ||. .
likevkad..ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1021-1298 9.1e-58 190.5 In-house 4-235 (392) alignment 
Range on Protein: 1021-1298
Range on HMM: 4-235/392.0
IRVENFEAYFKKQQAdsNCGFAEEYEDLKLVGISQpKYAAELAENRGKNRYNNVLPYDISRVKL-SVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNT
| | .| |. .|..   .. |.||. ||    |.. . .|.   |  ||||.|.|||| .||||  ..  . .||.|| |.|.....| .||.||| . .
ipvaqfpafveknrh..salffeefhdlpgpdiyp.qtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaas

LKDFWRMVWEKNVYAIIMLTKCVEQGrtkceeywpskqaqdygditvamtseivlpewtirdftvkniQTSESHPLRQFHFTSWPDHGVPDTTDLLINFR
|.||||||...|| .|.|.||  |                                            .  . .   ||||| |||..||  |  |..| 
lddfwrmvfqenvttiamvtklkegd..........................................kgddartvaqfhftewPdkdvpkhtssllkfi

YLVRDYMKQSppESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDI
  |.    |     |...||||||||||  |.|| .. . ..   |||. .| ..| .|| ||||..|| |.  .||. 
kevkadfGqy..thpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavled
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1021-1106 1.6e-10 34.9 In-house 6-89 (440) alignment 
Range on Protein: 1021-1106
Range on HMM: 6-89/440.0
IRVENFEAYFKKQQadSNCGFAEEYEdLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSK
| | .|  | ....      | .|.  |   |.|||   | | .|. |||| |.| || ||| |  |.    .||||| |. | .|.
iivadfadyvqnnr..rsrafedews.llpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingiesr
0043336 (Phosphotyrosine protein) phosphatases II 1022-1297 9.9e-97 319.0 In-house 3-275 (278) alignment 
Range on Protein: 1022-1297
Range on HMM: 3-275/278.0
RVENFEAYFKKQQADSNCGFAEEYEDLKLVGIsQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTH-STDDYINANYMPGYHSKKDFIATQGPLPNTL
.|.... ....  .... .. .|.|.|  . .  ... |.| ||. |||| ..|||| ||||||. .    .|||||.|..||. ...|||||||||.|.
svkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetv

KDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPsKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRY
.|||||||| .|  |.|||..|| ||.|| .||| .. . |||.|| ...|..|. .|.|...|.| ...||.  ...|...|||||||....||..|  
edFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflk

LVRDYMKqsPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD
 ||....  ....|.||||||||||||||||...|..|.|.| .||.. .| .||..|| .|||..||.|| ...|.
avreale..dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_PTPRK_pd Subfamily PTPRK 1022-1298 1.5e-80 265.4 In-house 5-276 (314) alignment 
Range on Protein: 1022-1298
Range on HMM: 5-276/314.0
RVENFEAYFKKQQADSNCGFAEEYEDLKLVgisqpKYAAELAENRGKNRYNNVLPYDISRVKLSV-QTHSTDDYINANYMPGYHSKKDFIATQGPLPNTL
||..     .. ..  . || |||| |          ||   ||| |||....|.|| |||.| . .  .  |||||... .|.  . ||.|||||..|.
rvadllqsiallkraegygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetv

KDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQdYGDITVAMTSEIVLPEWTIRDFTVKNI--QTSESHPLRQFHFTSWPDHGVPDTTDLLINF
|||||.|...|  .|.|||. ||.|| || .||| .  . |||| | . .  .| |  .| |.|...  . .| . .|||.|..||||.||     |...
kdfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllkl

RYLVRdyMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDI
   |   ..| . . .|.|||||| |||||||||| ..  ||.|..|||. .| .|| ... ||.||.||.|. . .|. 
vrrvk..ksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvilea
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1022-1301 1.3e-66 220.0 In-house 6-290 (325) alignment 
Range on Protein: 1022-1301
Range on HMM: 6-290/325.0
RVENFEAYFKKQQADSNCGFAEEYEDLKLVGiSQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQT-HSTDDYINANYMPGYHSKKDFIATQGPLPNTL
 | |.  . .|..|. . ||| |.. |  .. .. | .| . ||. |||..||...| ||| |  .   .  |||||.|.  .  |. |.|.| ||..|.
avvnlvehvekkkaqdqdgfahefgllpsdd.giakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltati

KDFWRMV--WEknvYAIIMLTKCVEQGRTKCEEYWPSK--QAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLI
.|.||.|  |.    ......  ...|  .|  ||| .  ... .| . | . .   . ..  | . ||...  |.  ..||.. ||.| ||.     ||
ndlWrlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatli

NFRYLVRDY---MKQ-SPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRS
..  ||      ..  .   .||||||||||||||.||..  .. .. .|  ||..| |  || .|| ||.| |||... ... . . |
silqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveayms
subfamily_PTPN9_pd Subfamily PTPN9 1023-1301 1.4e-83 275.4 In-house 3-292 (297) alignment 
Range on Protein: 1023-1301
Range on HMM: 3-292/297.0
VENFEAYFKKQQadsNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSV-QTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLK
.|...|| |...   . |  .||....   ..   .|..|  |  ||||..|| || .||.|.  . ... ||||||.. ||. || ||||||||..| .
ieelvayvkekg...krGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvs

DFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWP--SKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFR
||||||||..|  |.| |..||.|| || .|||  .......||..|.  .  .  ....| ...||..|.||  .  | |.||||.|||...  |....
dfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvl

YLVRDY-----------MKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRS
  ||..            |  | . ||.||||||.|||||||..|  . ..|...||||   |  ||  |  ..||..||.|  ..||.   .
ekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1023-1297 1.3e-74 246.4 In-house 18-289 (319) alignment 
Range on Protein: 1023-1297
Range on HMM: 18-289/319.0
VENFEAYFKKQQADSNCGFAEEYEDLKLVGISQP-KYAAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTL
... .   |..  |    .  |.  .  .|..   .  |.| .|. |||. |.|..| ..|||  ..     ||||| .. || .|. .||.||||.|||
ayyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntl

KDFWRMVWEKNVYAIIMLTkcveqgRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKN-IQTSESHPLRQFHFTSWPDHGVPDTTDLLINFR
.|||||.|| |. .|..||      . || .||| |  . ..   | ..|     |...||. . .  .  .   ..||||  |||.|||| .  |. . 
adfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlv

YLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD
  ||   ..   . .|.|||||||||||..|..| |. ....|. |||| .| |||  |. .||   || |.   .|.
kkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1023-1300 1.8e-51 169.5 In-house 11-284 (290) alignment 
Range on Protein: 1023-1300
Range on HMM: 11-284/290.0
VENFEAYFKKQQADSNCGFAEEYED-LKLVGISQPKYAAELAENR--GKNRYNNVLPYDISRVKLSVQthSTDDYINANYMPGYhsKKDFIATQGPLPNT
.| || .  .    .  ..| || . ||    .|.     . .|    |||| .|   |..|| |.       ||. |||. |   |  || |||.| .|
teafekfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdG..ydGdyvhanyvkGl..kamfiltqGalkdt

LKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQ--DYGDITVAMTSEIVLPEWTI-RDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLI
  |.|||| ...| ||.|| . .|.|..|||.|.| |. .   .|.|||  . |    . .| . ..|.. ..  .| |. ..  ||||. |. .|  |.
vidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlall

NFRYLVRDYmkqsppESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVR
   . .|          |. ||||||.||||||.||.  .  . .   .|. ..|  ||  |   || . ||. | . .||. .
rtlrilrka......sGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGk
0040438 (Phosphotyrosine protein) phosphatases II 1024-1300 1.7e-99 328.3 In-house 3-277 (317) alignment 
Range on Protein: 1024-1300
Range on HMM: 3-277/317.0
ENFEAYFKKQQADSNCGFAEEYEDLKLVGISqPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTH-STDDYINANYMPGYHSKKDFIATQGPLPNTLKD
.... . ..  . .. .. ||.|||  . .. .   ||| ||..|||| ..|||| ||||||. .    .|||||.|..|.. |. |||||||||||. |
ldlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntved

FWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLV
||||||| .|  |.|||...| || ||..|||... . |||.|| ..||..|...|.| ..|.. ..|||. ...||.|.|||||||...|||..|  .|
FwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleav

RDYMKqsPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVR
|....  .|..|.||||||||||||||||......|.| |..|||. .|. ||..|| .|||..||.|| ...|....
reale..dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylk
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1025-1304 2.9e-87 287.7 In-house 13-295 (298) alignment 
Range on Protein: 1025-1304
Range on HMM: 13-295/298.0
NFEAYFKKQQADSNCGFAEEYEDLKLVGI---SQPKYAAELAENRGKNRYNNVLPYDISRVKLSV-QTHSTDDYINANYMPGYHSKKDFIATQGPLPNTL
 .. . ..... .  |.|.|.. |. |     .. | .|.  ||. |||| .....| ||| |.  ..    ||||| .. .|. .. |||||.||..|.
alqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetv

KDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRY
.||||||.|... .|.|||. .|...||...|||..... ||.||| . |. .  . ..| ..|.. ...... .||.|||||||.||| ..  ..... 
edFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllr

LVRDyMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKD
 ||  ..|   ..|..|.|||||||.||||||| .. ....|..|||. .|  ||..|| .||||.||||. . ||. . | .|
kvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnd
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1027-1299 1.3e-60 200.1 In-house 8-280 (439) alignment 
Range on Protein: 1027-1299
Range on HMM: 8-280/439.0
EAYFKKQQADSNCGFAEEYEDLKlvgISQPKYA---AELAE--NRGKNRYNNVLPYDISRVKL-SVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTL
. . .| . . .  | |..| ..     .|.||   . .|.  .. ||||..| ..| .|| |  .       ||||||. ||. .| .||||||  .| 
qehvekldknkqeifkeifekin...stspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkett

KDFWRMVWEKNVYAIIMLTKCVEQGRtkceeYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNI--QTSESHPLRQFHFTSWPDHGVPDTTDLLINF
.||||.|.||..  |.|||. ||  .     ||||..   ||||.| .  .| ||...|| | | |   .|   . . |||...|||. ||  .  ...|
ddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldf

RYLVRDyMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD-IV
   .    ...    |..|||||||||||| ||.|  . |.  || ||. |||  || .|  |||.  ||||. ..||. ||
lrains.andkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavlediv
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1028-1301 1.7e-94 311.1 In-house 4-278 (281) alignment 
Range on Protein: 1028-1301
Range on HMM: 4-278/281.0
AYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTH-STDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRM
. .|......| ||.||||.|. .|....  |..  ||. ||||.|.  || .|||.. . . .. ||||||..|||...|..||||||.|..|..||.|
khlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqm

VWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQ-AQDYGDITVAMTSEIVLPEWTIRDFTVkNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDY
|||..| ||.|.|. .|.|. ||  ||| .. .  |||.|| .|.|   ...  | |.. . ...|.  ..|...|.|||||||.||  |..||  |. .
vweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkl

MKQSpPESPILVHCSAGVGRTGTFIAIDRLIYQIENE-NTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRS
 ...  . |...|||||||||||.||.|||. ..|.| ...||  .| .|| .| |||||  || |. . |||..  
tekk.tkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1028-1301 1.8e-94 311.0 In-house 10-281 (288) alignment 
Range on Protein: 1028-1301
Range on HMM: 10-281/288.0
AYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSV-QTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRM
|. .|..|... || |||. |  .. .. . |..||.|  ||||.|.||||  ||||   .. .. |||||.|. |...|| .|||||||..|..|||..
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

VWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQA-QDYGDITVAMTSEIVLPEWTIRDFTVKniQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDY
|.|...  |.|||. ||.|.||||||||...  . ||..|| ....  | ... | . ..  .. .   . |.....|||||||. .  |..... |   
vyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkva

MKQSppESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRS
 ..     ||.|||||||||||||||.| || ..|.|...|| |.|  ||..|.|.|||. ||.|. ...|...  
nqad..tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsliee
0036941 (Phosphotyrosine protein) phosphatases II 1029-1301 5.2e-101 333.1 In-house 3-279 (297) alignment 
Range on Protein: 1029-1301
Range on HMM: 3-279/297.0
YFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLsvqTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVW
. .. ..... .. .|.|.|  . .. ....|.| ||. |||| ..|||| .||||   ... .|||||.|..||. |. |||||||||||. |||||||
lkllekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvw

EKNVYAIIMLTKCVEQGRTKCEEYWPSK--QAQDYGDITVAMTSEIV--LPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRD
| ||  |.|||..|| || ||..|||..  . . |||.|| ..|. |  |...|.| ..|......||. ...||.|.|||||||.... |..|  |||.
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk

YMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIE---NENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRS
..|..|...|.||||||||||.|||||.| ...|.|    |..||.. .|  ||..|| .|||..||.|| ...|. ...
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk
subfamily_PTPN6_pd Subfamily PTPN6 1030-1303 7.3e-81 266.5 In-house 17-301 (306) alignment 
Range on Protein: 1030-1303
Range on HMM: 17-301/306.0
FKKQQADSNCGFAEEYEDLKLVGIS--QPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHSTDDYINANYMPG--YHSKKDFIATQGPLPNTLKDFWR
 |...  .. || ||.|.|.    .    .  .. .||. ||||.|.||.| .||.|. .  . .|||||||. .    |.| .||||| |..|..||||
ekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWr

MVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQA-QDYGDITVAMTSEIVLPEWTIRDFTVK-NIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVR
|||..|   |.|.|| ||.|. ||  |||.... ..||.|.| ..||  | ....|...|. . . .|.. ..|.||.||||||||  .. ...|   |.
mvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvn

DYMKQSP--PESPILVHCSAGVGRTGTFIAIDRLIYQIENE---NTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQK
  ....    . ||.||||||.||||||| || |. .||..     .|.. .|  .| .|  .||||.|| |. . .   ....|
rkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk
0047943 (Phosphotyrosine protein) phosphatases II 1031-1297 6.2e-101 332.7 In-house 4-270 (273) alignment 
Range on Protein: 1031-1297
Range on HMM: 4-270/273.0
KKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLsvqTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEK
. ...... ...||.|.|. . .. ....|.| ||. |||| ..|||| |||||   .....|||||.|..||..|. |||||||||||..||||||||.
llekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

NVYAIIMLTKCVEQGRTKCEEYWPSKQ---AQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMK
||  |.|||..|| || ||. |||...    . ||..|| ..|| . . .|.| ....|..|.||.  ..||.|.|||||||.... |..|  |||....
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkale

QSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD
..| ..|..|||||||||||||||.| |..|.| |..|||. .|. ||..|| ||||..||.|| ...|.
alpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
0045098 (Phosphotyrosine protein) phosphatases II 1035-1299 1.9e-89 295.0 In-house 3-272 (278) alignment 
Range on Protein: 1035-1299
Range on HMM: 3-272/278.0
ADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKlsvqthstdDYINANYMPGYhsKKDFIATQGPLPNTLKDFWRMVWEKNVYA
|.... .  |.| | | || .  . | . .|. |||| ..|||| ||||         |||||.|..||  .| |||||||||.|. |||||.|| .. .
alasldlllefefllllgipseitpalylgnldknRykdilpydhsrVk.........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitv

IIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNI----QTSESHPLRQFHFTSWPDHGVPDTT--DLLINFRYLVRDYMK-
|.|||..|| || ||..|||... . |||.|| ..|| ||...|.|...| |.    .. ||. ....|...|||||||...  . ....   .|...| 
ivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkl

----------QSPPESPILVHCSAGVGRTGTFIAIDRLIYQIenENTVDVYGIVYDLRMHRPL-MVQTEDQYVFLNQCVLDIV
          . ... |.|||||||||||||..|.. .....  |..||.. .|  ||..||  .||...||.|| ...|...
laslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1035-1296 1.9e-56 186.0 In-house 12-290 (301) alignment 
Range on Protein: 1035-1296
Range on HMM: 12-290/301.0
ADSNCgFAEEYEDLKLvGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTH---STDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKN
. ||  |.|.|..||  | ...       ||.  ||..|. .||  |. |. ...   .. .||||.|. || .|| |||.|||. .||.||||..|.. 
khsnk.feeqykelke.gedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqek

VYAIIMLTKCVEQGRTKCEEYWPS--KQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTS---------------ESHPLRQFHFTSWPDHGV-PDTTD
. .|.|.|.  |. ..|||.|||.  .. ...| .|| ...| |.|...||...||  ..|               .|. . |.. |.||..|| ..   
pvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprt

LLINFRYLVRdyMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVL
 |      .    .|..  .|..||||..|.|.|......  . |   |  |||....  .|  .| .|.| .||... . . 
vLqviddvih..rqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvid
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1036-1297 1.2e-45 150.6 In-house 3-257 (267) alignment 
Range on Protein: 1036-1297
Range on HMM: 3-257/267.0
DSNCGFAEEYEDLKLVGISQPKYAAELAE-NRGKNRYNNVLPYDISRVKLSvqtHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYA
|..| . .|.| .| .   . . .  .|| |. .||....|||| .|| |.    ....|||| |. ||. |. ||.||.|| ||  ||. .. ...|  
deeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilr...tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpv

IIMLTKCVEQgrtKCEEYWPSK--QAQDYGDITVAMTSEIVLPEWTIRDFTVKNiQTSESHPLRQFHFTSWPDHgVPDTTDLLINFRYLVRDYMKQSppE
|..|||  ..   .   .|| |  ||. | |.||  . |    .. |  . .|  .   .| .  ...  |    . .   |   |  | .. ...   .
ivlltkvftd...nirlfwPPkmgqakkyqdltvehslekeendyqiitlelkf.knesahnvtlyyykkwnin.tnnkpylkplfgilaknqleng..n

SPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD
 |..|.||.||||.|||. ||  . .. .|...|..  .  .|  |. .|.| ..|... . . .
rPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1037-1298 1.4e-73 242.8 In-house 16-275 (515) alignment 
Range on Protein: 1037-1298
Range on HMM: 16-275/515.0
SNCGFAEEYEDLKLVGISqPKYAAELAENRGKNRYNNVLPYDISRVKLSV-QTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAI
  . |.||. ||    |  |.  |.   |  ||||.|.|||| .|||| | .     ||.|| |.|.... | .||.|||.. ...||||.|...|| .|
httlfseefhdlpgpniy.pqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvtti

IMLTKCVEQGRTKCEEYWPSKQA--QDYGDITVAMTSEIVLPEWTIRDFTVknIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPpeS
.|.||  |. . || .||| | .    .| | | . |     . ..| .||  .. ..|. . ||||| |||.|||  |  |. .   |.    |     
amvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltv..lkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt..h

PILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDI
|...|||||||||| .|.||  . .... ..|||. .|  .| .|| .|||..|| |. . ||. 
pliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavled
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1038-1299 8.9e-61 200.2 In-house 5-266 (283) alignment 
Range on Protein: 1038-1299
Range on HMM: 5-266/283.0
NCGFAEEYEDLKLVGIS-QPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHstdDYINANYMP---GYHSKKDFIATQGPLPNTLKDFWRMVWEKNVY
. ..   .| || ...  ..   |   ||. |||.....|.|  ||.|  ...   ||||| ..|    |. .|..|..|.|| .| .|||.||..... 
vnnnklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr...dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekit

AIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESH-PLRQFHFTSWPDHGVPDTTDLLINFRYLVRDyMKQSpPE
||.||||  |. | ||  |||.. ..|||. ||..  |     ..|. .....  ...|   |  . .  | . |     . |..|  ..    ..| ..
aivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvisl.qtes.kk

SPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIV
.||.||||.|.|||..|||.   . ..  |  |||. .|  .| .|. .||| ||| .. . ||.  
gPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqa
0046845 (Phosphotyrosine protein) phosphatases II 1040-1300 3.5e-100 330.3 In-house 1-275 (284) alignment 
Range on Protein: 1040-1300
Range on HMM: 1-275/284.0
GFAEEYEDLKLVGISQ--PKYAAELAENRGKNRYNNVLPYDISRVKLSVQTH--STDDYINANYMPGY-----HSKKDFIATQGPLPNTLKDFWRMVWEK
|. ||.| |  . ...  . ..| | ||. |||| ..|||| |||||..  .  ...|||||.|..||     ..|| |||||||||||..||||||||.
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

NVYAIIMLTKCVEQGRTKCEEYWPSKQ-AQDYGDITVAMTSEIVLPEWTIRDFTVKNIQ-TSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQ
||  |.|||..|| ||.||. |||...  . |||.|| ..|| | . .|.| ....|.. |.||. ...||.|||||||||.... |..|  |||.....
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

SPPESPILVHCSAGVGRTGTFIAIDRLIYQIENEN---TVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVR
.|...||.|||||||||||||||.| |..|.|.|.   .|||...|. ||..|| ||||..||.|. ...|. ..
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1040-1311 1.4e-40 134.0 In-house 23-301 (305) alignment 
Range on Protein: 1040-1311
Range on HMM: 23-301/305.0
GFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLsvQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLT
|. .|.  .| .   .   |   |...||||| .|   |  ||||  ..    .|| |||.      | || || || .|  ||| | ....| ||.|| 
glraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkl..egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlc

KCVEQGRTKCEEYWPSKQAQD------YGDITVAMTSEIVLPEWTIRDFTVKN----IQ--TSESHPLRQFHFTSWPDHGVPDTtDLLInfrylVRDYMK
. .|.|  || ||..||. .          |.| . |   |   .  . .|..    |.   ....   ..|.  ||| ||| . || |     .    |
nllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaa.dlai.....lellek

QSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVD-VYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQK--DSKVDLIY
  |   || ||||||.||||. . .. .. |. . . ..    |.  .|  |   .||..||.|. | .|. .| .|  | .|. .|
arpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkklldeevkeay
DSPc_SM00195 1041-1299 1.5e-91 301.7 In-house 2-262 (263) alignment 
Range on Protein: 1041-1299
Range on HMM: 2-262/263.0
FAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTH-STDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLT
. ||.|.|.    ....  ||  .|. ||||.|.|||| .||||. . . ...|||||||. |...||..||||||||.|..||||||||..|  |.|||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

KCVEQGRTKCEEYWPSK--QAQDYGDITVAMTSEIVLP-EWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSppESPIL
...|.|..||..|||..  . ...|.|.| .....  . |...|...... ...|.. ..|.....||||||||.|. ....   |.   ..|  ..||.
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpiv

VHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIV
|||||||||||||..|| .. ..|.|..||.  ||  ||..|| ||||..|| |. ...|. .
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1041-1299 1.5e-91 301.7 In-house 2-262 (263) alignment 
Range on Protein: 1041-1299
Range on HMM: 2-262/263.0
FAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTH-STDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLT
. ||.|.|.    ....  ||  .|. ||||.|.|||| .||||. . . ...|||||||. |...||..||||||||.|..||||||||..|  |.|||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

KCVEQGRTKCEEYWPSK--QAQDYGDITVAMTSEIVLP-EWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSppESPIL
...|.|..||..|||..  . ...|.|.| .....  . |...|...... ...|.. ..|.....||||||||.|. ....   |.   ..|  ..||.
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpiv

VHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIV
|||||||||||||..|| .. ..|.|..||.  ||  ||..|| ||||..|| |. ...|. .
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPN13_pd Subfamily PTPN13 1042-1300 9.6e-72 236.5 In-house 14-270 (273) alignment 
Range on Protein: 1042-1300
Range on HMM: 14-270/273.0
AEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHstddYINANYMPGY--HSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLT
|||...|. .   .    .. .||. |||| |||||| .||||. ..     ||||...     . . ..||.|||||.| ||||.||||...  |.|.|
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt

KCVEQGRTKCEEYWPSKQAQD---YGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKqspPESPIL
. .|.|. ||. |||... .    .. ..|..     | ....|...||.....||. . ...|..||||||| ... |..|   ||   .    ..||.
lekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt...dagPiv

VHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVR
||||||.||.||.|.|| ..  ||... .||  || .||  |  .|||.|||.|  . .|....
vhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_CG42327_pd Subfamily CG42327 1042-1226 4.4e-30 99.4 In-house 8-194 (319) alignment 
Range on Protein: 1042-1226
Range on HMM: 8-194/319.0
AEEYEDLKLVgISQPKyaAELAENRGKNRYNNVLPYDISRVKLSVQ-THSTDDYINANYMPGYHS-KKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLT
|||..||  . |..    .  .  . |.|. ||.|   .|| |  .  .  | |..|.|. ||.. .  .||.| .| ..  ||||.|||..   |. ||
aeefrdlPql.iarad..evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqlt

KCVEQGRTKCEEYWPSKQA----QDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFtSWPDHGVPDTTDLLINFRYLVRDYM
.  |.|  .| ||.|.|..    . |||| |..    |  .. |  . .|... .|| .|  . .  |.. .||     ||     ||. .
dlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrssl
subfamily_PTPN14_pd Subfamily PTPN14 1043-1300 1e-59 197.0 In-house 27-297 (300) alignment 
Range on Protein: 1043-1300
Range on HMM: 27-297/300.0
EEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHSTDDYINANYMPG--YHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTK
 ||| ..        ..|.| ||  |||...||||. .||.|| . .....||||  .      .....|..||||..|..|||.||||..|. |.|||.
teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlte

CVEQGRTKCEEYWPSK----QAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQ---S----
  |.|..|. .|.|..    .  ..|   |        .  . . ...| . ..|   .  . .| |||||||.  .  ...   |.   ..   .    
eeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnsevesk

PPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVR
  . |.||||||||||||  |  | ||. .|.....|.  ..  ||  | |.|||  || |. . ..  ..
eskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_PTPN1_pd Subfamily PTPN1 1044-1312 7.1e-67 220.1 In-house 11-285 (290) alignment 
Range on Protein: 1044-1312
Range on HMM: 11-285/290.0
EYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHstdDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVE
 |.|..      |  .|.| |||..||| .| ||| ||.||  .     |||||. .   . |. .| |||||||| . ||.||||..  |..|| |.||
iyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn...dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvve

QGRTKCEEYWPSKQAQ-----DYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVH
....|| .|||... .     .   ..| . || .  ..|.| . ..|..| |.. . .||.|.||| |||..   ...| . ||.    |.   | ..|
keqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavih

CSAGVGRTGTFIAIDRLIYQIENENT---VDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVR-SQKDSKVDLIYQ
||||.||.|||. .| .. .||...    ||.   . .|| .|  ..|| ||  |  . .|. ..  ..|| |. ...
csaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssvqkrwk
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1044-1140 6.9e-13 42.8 In-house 15-118 (347) alignment 
Range on Protein: 1044-1140
Range on HMM: 15-118/347.0
EYEDLKLVGISQPKYA-AELAENRGKNRYNNVLPYDISRVKLSV------QTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAII
 | | .| . | .|.. .|   .  ||| ..|   | .|| ||       ..  .. |||| ..    ..|..| || |||.|..|||.||   .|  ..
tyfdenlanyspskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvv

MLTK
 . .
tife
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1052-1161 2.3e-07 23.9 In-house 14-90 (169) alignment 
Range on Protein: 1052-1161
Range on HMM: 14-90/169.0
GISQPKYAAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINAnympgyhskkdfiatqgplpntlkdfwRMVWEKNVYAIIMLTKCVEQgrtkcE
 |   .. |||. |  |||    |     ||||  |  .   |||||                           ||.|| |   |..|  . ..     .
tieynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddk.....n

EYWPSKQaqDY
..|| |.  ||
nfwpeke..dy
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1052-1161 3.4e-07 23.2 In-house 13-89 (169) alignment 
Range on Protein: 1052-1161
Range on HMM: 13-89/169.0
GISQPKYAAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINAnympgyhskkdfiatqgplpntlkdfwRMVWEKNVYAIIMLTKCVEQgrtkcE
 |   .. |||. |  |||    |     ||||  |  .   |||||                           ||.|| |   |..|  . ..     .
tieynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddk.....n

EYWPSKQaqDY
..|| |.  ||
nfwpeke..dy
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1055-1292 6.1e-19 62.7 In-house 36-272 (303) alignment 
Range on Protein: 1055-1292
Range on HMM: 36-272/303.0
QPKYA-AELAENRGKNRYNNVLPYDISRVKLSvqthsTDDYINANYMPgYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYW
 |. .  .. .|  |||. .|.  | |.||||        || |.|.   .|.|  | || ||. |  |||.|. |..|  ...|    |  .   .  .
ppsvsknqfvknmdknrfvdvicldhskvkls.....dssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvf

PSKQA-QDYGD--ITVAMTSEIV-LPEWTIRDFTVKNIQTSesHPLRQFHFTSWPDHGVPDT-TDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGT
| .|   .. .  | |    ..     |...  .| | .      |   |. .||   .|   .  ...  . .. ....  . .| .    .|.||.||
prnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyk..sflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragt

FIAIDRLIYQIENEN-TVDVYGIVYDLRMHRPLMVQTEDQYVFLN
|  ..     . .|. ..|.   .  .|  |   ||   |. .. 
falfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvy
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1055-1145 3.8e-09 30.5 In-house 24-114 (332) alignment 
Range on Protein: 1055-1145
Range on HMM: 24-114/332.0
QPKYAAELAENRGKNRYNNVLPYDISRVKLSVQThSTDDYINANYMPGYHSKKDFIATQGPLPN-TLKDFWRMVWEKNVYAIIMLTKCVEQG
 |.   .. .|   ||   .  .| |||.|. |    ||. ||... ||  |  .| .| |. . |   ||||| |..   |...    |. 
ypntydkflnnmdmnriphlycfdhsrvelapqd.gkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekq
subfamily_PTPN12_pd Subfamily PTPN12 1056-1304 2.5e-82 271.0 In-house 31-282 (290) alignment 
Range on Protein: 1056-1304
Range on HMM: 31-282/290.0
PKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHST-DDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWP
.. |.|  ||. |||| ..|||| |||.|| ....  .||||||.. | ..|. .||.|||||.||.|||||.|||||  ..|. . || |..||| |||
steagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWp

SKQAQ--DYGDITVAMTSEIVLP-EWTIRDFTVKNIqtSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKqsPPESPILVHCSAGVGRTGTFIA
... .   .|...| ...|  .  ...|| ..|..   .||. ..|||.|.||||||| ... |...  |||.. .    ..|..|||||||||||| ||
eegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGrtGtiia

IDRLIYQIENENT---VDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKD
||    ....|..   .||. .| .|| .|. .|||..||... ..|...|... .
idyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkele
0040439 (Phosphotyrosine protein) phosphatases II 1057-1298 2.1e-89 294.6 In-house 3-245 (249) alignment 
Range on Protein: 1057-1298
Range on HMM: 3-245/249.0
KYAAELAENRGKNRYNNVLPYDISRVKLSV-QTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPS
.. |.| ||. |||| ..|||| ||||||. . .  .|||||.|..||..|..|||||||||.|..|||||.|| .. .|.|||..|| || ||..|||.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

KQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRL
.. . |||.|| ..|..|....|.| ....|....||.  .....|.|||||||.... |..|  .||..... |...|.||||||||||||||||.. .
ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm

IYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDI
..|.| |..||.. .| .||..|| .||...||.|| ...|..
leqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
subfamily_PTPRN_pd Subfamily PTPRN 1058-1299 3.3e-59 195.0 In-house 49-292 (297) alignment 
Range on Protein: 1058-1299
Range on HMM: 49-292/297.0
YAAELAENRGKNRYNNVLPYDISRVKLSVQT-HSTDDYINANYMPGYHSK-KDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPS
 .|.  .|  |||...||||| |||||. .. ....|||||  .     .   .|||||||..|. |||.||||. |  |..||.  |.| ..|..||| 
evakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpd

KQAQDYGDITVAMTSEIVL-PEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQspPESPILVHCSAGVGRTGTFIAIDR
. .. |.   | . || .   .. .| | .||.||||.  . |||| |||..||| ..  |..||  |    .     .||.||||.|.||||..|.|| 
eGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG..rscpivvhcsdGaGrtGvyilidl

LIYQIEN-ENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIV
.. .. .  . .|.   .  ||  || .|.|.||. |  ..| . |
vlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1058-1299 3.5e-40 132.8 In-house 36-271 (288) alignment 
Range on Protein: 1058-1299
Range on HMM: 36-271/288.0
YAAELAENRGKNRYNNVLPYDISRVKLSvqtHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQ
 . .  .|  ..||.|.   ||.|||||     .| ||.|| ..  . |. .| .| ||  |.. .|.|. |..|  |.||.. .|.|. | .||.|||.
iidsfianptrdryenlprcditrvkls...ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPskl

AQD--YGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHP-LRQFHFTSWPDHGVPDTtdLLINFRYLvrDYMkqSPPESPILVHCSAGVGRTGTFIAIDR
 .   .| .   .  . .  . ...  .... .. | .  ... |.  |.|.|||.    |  .| |  . .     . ||.||.|||||||||.| |  
GekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPen..ylsplrll..evl..kslqkPivvhssaGvGrtgtlilili

LIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIV
 . ..  .. . .  ..  || .|   .||| ||... .|||. .
aleslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel
0037934 (Phosphotyrosine protein) phosphatases II 1059-1297 3.5e-81 267.6 In-house 4-240 (243) alignment 
Range on Protein: 1059-1297
Range on HMM: 4-240/243.0
AAELAENRGKNRYNNVLPYDISRVKLsvqthSTDDYINANYMPGYhskKDFIATQGPLPNTLKD----FWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWP
 | | ||. |||| ..|||| |||||     . .||||||.....   . .||||||||.|..|    ||||.|| .. .|.|||..|| || ||..|||
iallpenlsknrysdilpydhsrvkl.....egsdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

sK-QaqDYGDITVAMTSEIVLPEWTIRDFTVKNIQ-TSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQ------SPPESPILVHCSAGVGRT
   .   |||.|| ..|| .|...|.| ....|.. . ...  ...|...||||||||... |..|   ||.....       ....|.|||||||||||
.gev..tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRt

GTFIAIDRLIYQIenenTVDVYGIVYDLRMHRPL-MVQTEDQYVFLNQCVLD
||.||.. .....    .||.. .| .||..||  .|||..||.|| ...| 
Gtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_PTPN3_pd Subfamily PTPN3 1059-1299 1.4e-73 242.3 In-house 35-275 (280) alignment 
Range on Protein: 1059-1299
Range on HMM: 35-275/280.0
AAELAENRGKNRYNNVLPYDISRVKLSvqTHSTdDYINANYM----PGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWP
|| ..||  |||| ..||||. ||||.    .| |||||||.    |. .  . .|||||||..| .|||.||||...  |.|||  ||.||.|| .|||
aarkpenlsknryrdilpydatrvklk..eset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWP

SKQ-AQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQspPESPILVHCSAGVGRTGTFIAID
...  ..||...| ...|    .. .|....|. .|.|.... |. ...|||||||| .. ...|   ||.. .    |.|..||||||.|||| .|...
etedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsg..keePvvvhCsaGigrtGvlille

RLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIV
  .  ||... | .  ||  .|  |  .|||..|| |. ...| . 
talalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvy
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1059-1297 5e-73 241.1 In-house 19-253 (284) alignment 
Range on Protein: 1059-1297
Range on HMM: 19-253/284.0
AAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTkcveqgRTKCEEYWPSKQ
 |.| .|. |||. ..|..| ..|||  ..     ||||| .. || .|. .|||||||.|||.|||||.|| |. .|..||      . || .||| | 
fanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplki

AQDYGDITVAMTSEIVLPEWTIRDFTVKN-IQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLI
 . ..   | ..|     |...||. . .  .  .   .|||||  |||.|||| .  |. .   ||   ..   ...|.|||||||||||..|..| |.
vikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvll

YQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD
 ....|. |||| .| |||  |. .||   || |.   .|.
drmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1059-1296 3.4e-62 204.8 In-house 33-274 (287) alignment 
Range on Protein: 1059-1296
Range on HMM: 33-274/287.0
AAELAeNRGKNRYNNVLPYDISRVKLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQA
| ||| .  |||| .|||.| .|| || ...   |||||||...|. .. |||.|||.. |..||||.|.|... ..|..|. ||..| || .||| .. 
aeela.avkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerev

Q-DYGDIT-VAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYM---KQSPPESPILVHCSAGVGRTGTFIAID
    |  . |..  .|  ||...| . . ...| |.. ..|... ||||.... |.  || |   |....   ...    |..||...|.||.|...|. 
PmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatl

RLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVL
 |. . |.   |||  .|  ||..|  .||.  |. .| . . 
vlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
0049772 (Phosphotyrosine protein) phosphatases II 1059-1302 1.4e-49 164.8 In-house 40-283 (314) alignment 
Range on Protein: 1059-1302
Range on HMM: 40-283/314.0
AAELAENRGKNRYNNVLPYDiSRVKLSVQTHSTDDYINANYMPGYhskKDFIATQGPLPNTLKDF----------WRMV--WEKNVYAIIM---------
.| | .|| |||| ..||.| .||.|. . .|. |||||.|. |.   ..||||||||..|. ||          ||||  .. ||  | |         
vadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlade

------------LTKCVEQGrtkceeywPSKQAQDYGDITvamtseivlpewtirdfTVKNIQTSESHPLRQFHFTSWPDHGVPdTTDLLINFRYLVRDY
            |... ..|        .   |.|. ..                  .. . .   ...  ... . .||...| ... .  |  .....
lsrLdaAlgKtpllildgng........neptaadlellk.................eelydpelferlgikylripvpDgsap.lledfdeflefieea

mkqsPPESPILVHCSAGVGRTGTFIAIDRLIYQIenenTVDVYGIVYDLRMHRP-----LMVQTEDQYVFLNQCVLDIVRSQ
    ....|.||||.||.||||||.... |...      |..  .. |.|. ||      .... .||.|  ...|. .. .
....dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylkfl
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1059-1103 9.2e-08 26.0 In-house 33-77 (244) alignment 
Range on Protein: 1059-1103
Range on HMM: 33-77/244.0
AAELAENRGKNRYNNVLPYDISRVKLSVQTHSTDDYINANYMPGY
 | |. |  |||| |.||.| .|| ||   .   |||||||. | 
navlsanatknryinilpfdetrvilssskkegsdyinanyiqgs
0042113 (Phosphotyrosine protein) phosphatases II 1060-1297 4.5e-87 286.8 In-house 4-241 (245) alignment 
Range on Protein: 1060-1297
Range on HMM: 4-241/245.0
AELAENRGKNRYNNVLPYDISRVKLSVQTHST-DDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQA
|.| ||. |||| ..|||| .|||||.  ..  .|||||.|..||. .. |||||||||.|..|||||.|| .. .|.|||...| || ||..|||... 
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplges

QDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQsPPESPILVHCSAGVGRTGTFIAIDRLIYQ
. |||.|| ..|| .|...|.| ..|.|....||.  ...|...||||||||...||..|  .||..... ... |.||||||||||||||||......|
ltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylmleq

IENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD
.| | .|... .|..||..|| .|||..||.|| ...|.
lekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1060-1304 1.6e-77 255.1 In-house 4-247 (250) alignment 
Range on Protein: 1060-1304
Range on HMM: 4-247/250.0
AELAENRGKNRYNNVLPYDISRVKLSVQT-HSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTkCEEYWPSKQA
|.  .|. |||| .....| ||| |  .      ||||| .. ||. .| ||||||||..|..||||||.|... .|.|||. .|...| ...||| ..|
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka

QDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQsPPESPILVHCSAGVGRTGTFIAIDRLIYQ
. |||.|| . |. .  ..|.| . . . . ...  .||.||..||| |||...   ....  |.   .|   ..|..|.|||||||.|.||||| .. .
ekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqq.agnaPvivqCsaGvgrsGafiaidavler

IENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKD
...|..|||. ..  || .|| .|....||||. . .|  . | .|
lkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsved
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1060-1296 4.4e-73 240.7 In-house 23-265 (274) alignment 
Range on Protein: 1060-1296
Range on HMM: 23-265/274.0
AELAENRGKNRYNNVLPYDISRVKLSVQTHSTD--DYINANYMPGYHSK-KDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSK
 ... .  ||||...|| . ||| |. .. . .  .||||||. ||. . | ..|||||||||..|||||.....|  |.||||  |. ..||..|.| .
ldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPda

QAQ----DYGDITVAMTSEIVLPEWTIRDFTVKNIQTSEShpLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPE-SPILVHCSAGVGRTGTFIA
.       |||. . ... .   ....| ...|. . . |  .  . .|.|||| .|| .. |...   |..  ...  . .|..||||||.|||| |||
edyeiserygdveikvekiverndysvrklvlkylerers..vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfia

IDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVL
|.  . |...|..||| .|| .||..|  ||||..|| .. . . 
isiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1060-1300 8.6e-70 229.8 In-house 15-265 (270) alignment 
Range on Protein: 1060-1300
Range on HMM: 15-265/270.0
AELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHS-KKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQ
 | | ..  |||...||   .||.|. ... |.  ||||||..|... || .||..||||.|||.||||.||..| ||.|.|. .|.||.||| |||...
peaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaep

AQ----DYGDITVAMTSEIVLPEWTIRDFTVKniQTSESHPLRQFHFTSWPDHGVPDTTD------LLINFRYLVRDYMKQSPPESPILVHCSAGVGRTG
 .     .|.|.|. .||     . ..  ...  ...|.. |  |....||||||| ..|       |..    || . |.   ..|.||||||||||||
kekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtG

TFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVR
|.||.|  .  .|... |||  |. .|| .|. .||. .|| || . |.  ..
tlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1060-1296 4.3e-57 188.0 In-house 3-238 (239) alignment 
Range on Protein: 1060-1296
Range on HMM: 3-238/239.0
AELAENRGKNRYNNVLPYDISRVKL---SVQTHStdDYINANYMPGYH-SKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPS
|.   |. |||| |.. || ||| |   | . ||  |||||.|.  |  | | .||||| .  .  |||||.|..    |.|||  .|  . || .||| 
akkrvnkaknryanivtydhsrvvleklsndphs..dyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd

KqAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRylvRDYMKQS-PPESPILVHCSAGVGRTGTFIAIDR
  .  | .. |..    |. .. || | . ..  .| . . |.||| |||.|||. .  .. .|   |   |.| |   | ..||||||||||.|. || 
s.tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglr...rkitkdslpgarpwvihcsagvgrtgaflvida

LIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVL
.. | ....|||..  |  .|  || |||| .||||.  .||
mlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1060-1298 1.3e-20 68.1 In-house 46-284 (302) alignment 
Range on Protein: 1060-1298
Range on HMM: 46-284/302.0
AELAENRGKNRYNNVLPYDISRVKLSvqtHSTDDYINANYMPGYHSKKDFIATQGPLPNTL---KDFWRMVWEKNVYAIIMLTKCVEQGRtKCEEYWP--
    .|  ||. ..|  .|  .|||.   .. |.|.||  .   . ..  | .| |  ..     .|||||.....  . .| .  |  .   .|..|  
kafkknlkknqsedvpildsnlvkle...aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkk

SKQAQDYGDITVAMTSeI-VLPEWTiRDFTVKNI--QTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVrdYMKQSPPESPILVHCSAGVGRTGTFIA
| . ..||.. |     .    | .   ...  .    |.|      ..| |... ||.    ||.    |  ..|... ......    |.|| |.|..
sgdykeygkmfvNnrk.Vekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv..fakkikadentvivSknGaGRagaflt

IDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDI
    . ...... . .  ||  .|  || .|.. .|||.|  ..|  
lavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiallly
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1061-1298 8.2e-49 161.2 In-house 37-276 (307) alignment 
Range on Protein: 1061-1298
Range on HMM: 37-276/307.0
ELAENRGKNRYNNVLPYDISRVKLSVQTHSTdDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQD
 .  |  ||||..|   | .|. . ..  .. ||| |||.      | ||..|||| ||  .|| |. ...| ..||| |..| .. |||.||| .. | 
afsantdknryqdvkcqdkgrivvkfdglas.dyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqk

--YGD----ITVAM-TSEIVLPEW-TIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDymKqsppESPILVHCSAGVGRTGTFIAI
  .|.    |.||   .. . |.   |   |.|   ...|  .... .. |||.|||..    ||.   ||   .    . |..|||||||||.|| .||
lvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry..d....tnpvvvhcsaGvGrsGtivai

DRLIYQ-IENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDI
  .  . |. .|  |.  .| .|| .|.  .||| ||..| . .|. 
slvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
subfamily_CG7180_pd Subfamily CG7180 1062-1300 2.2e-61 202.1 In-house 39-291 (296) alignment 
Range on Protein: 1062-1300
Range on HMM: 39-291/296.0
LAENRGKNRYNNVLPYDISRVKL-SVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRtKCEEYWPSKQAQD
 .|||.|||. .|.|||  || | ... ....||||| |. ..  ||..| |..|  .|...|||.|..... |...|||  .. . .. .||| |. ..
rkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeq

YGDITVAMTSEIVLPEWTIRDFTVKNI-------QTSESH---PLRQFHFTSWPD-HGVPDTTDLLINFRYLVRDYMKQS---PPESPILVHCSAGVGRT
||.| | ...|  ... .|| | ..         .. ..     ...|..| |.  . ||  |  ||..|  || ....    | |.|..|..| |..|.
ygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRs

GTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVR
| ..|||  . ..|.|. |||.. |  || .|| .|.. ..| .. . .|. | 
GvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
subfamily_ptpA1_pd Subfamily ptpA1 1062-1252 2.2e-42 140.3 In-house 44-249 (418) alignment 
Range on Protein: 1062-1252
Range on HMM: 44-249/418.0
LAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSkKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSK----
   |  |||| |.|| . .||.|  .| .   |||||||. | .  |.||.||||||||. ||||||||. .  |.||..  |. | ||. ||| .    
kkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge

QAQDYGD-------ITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPP----ESPILVHCSAGVGR
|   ||.        .| .   |  ||  |    ..     |.. . |...  |||| .|| |. . .. . . .  .|  |    . ||.|||||||||
qfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgr

TGTFIAI
|||| . 
tgtfcta
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1062-1306 1e-39 130.9 In-house 49-297 (310) alignment 
Range on Protein: 1062-1306
Range on HMM: 49-297/310.0
LAENRGKNRYNNVLPYDISRVKLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQ-AQD
  ..  |||| .|.  | ||||| ..    .||| |||.   . .. || .||||  |. |||||....   .|..| | .|.|| ||  ||||   .. 
ykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtet

YGDITVAMTSEIVlPEWTIRDFTV----KNIQT----SESHPLR--QFHFTSWPDHGVPDTTDLLINFRYLVRdyMKqsppESPILVHCSAGVGRTGTFI
|| | |.  ||    |. | ...|     |.      .. . ||    ..  ||| ||||     .  | | .  ..      | .||||||..|... .
ygcirvtnlsess.eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaq..vr....hgpcvvhcsagkdrlyvvv

AIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDSK
|..  | .... . ||.  .. .|. .|   .||| ||.....  . ..|....  
alklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifargeteva
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1063-1297 3.6e-57 188.3 In-house 5-238 (239) alignment 
Range on Protein: 1063-1297
Range on HMM: 5-238/239.0
AENRGKNRYNNVLPYDISRVKL---SVQTHStdDYINANYMPGYH-SKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKqA
  |. |||| |.. || ||| |   | . ||  |||||.|.  |  | | .||||| .  .  |||||.|..    |.|||  .|  . || .|||   .
rvnkaknryanivtydhsrvvleklsndphs..dyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.t

QDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRylvRDYMKQS-PPESPILVHCSAGVGRTGTFIAIDRLIY
  | .. |..    |. .. || | . ..  .| . . |.||| |||.|||. .  .. .|   |   |.| |   | ..||||||||||.|. || .. 
skycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglr...rkitkdslpgarpwvihcsagvgrtgaflvidamlr

QIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD
| ....|||..  |  .|  || |||| .||||.  .||.
qakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1063-1296 4.6e-37 122.5 In-house 33-267 (285) alignment 
Range on Protein: 1063-1296
Range on HMM: 33-267/285.0
AENRGKNRYNNVLPYDISRVKLsvQTHStDDYINANYM--PGYhSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQ-
  |   ||| .|   . .|| |  . |   ||| |..|  ||   .  .|.||||||.|| |||.|......  ..||   .| |  ||  |.| |  . 
eanpdlnryadvrcieetrvvl..knhd.rdyihaswmrmpgk.dqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev

-DYG--DITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHF--TSWPDHGVPDTTDLLINFRYLVRdymKQSPPESPILVHCSAGVGRTGTFIAIDR
  .|  .||..   |  .    .  .|| | . . | ||   |     |||.  |. .  .|..   |.   |  | | || |||||||||| ||. || 
vkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvk...kvnpkekpicvhcsagvgrtatfvgidy

LIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVL
   .| ..  ...  || ..|  |   ||.  |..||   ..
atirimenpniemldivremramrfqavqshmqflflyvvlm
subfamily_egg_pd Subfamily egg 1063-1309 2.6e-29 96.9 In-house 38-284 (307) alignment 
Range on Protein: 1063-1309
Range on HMM: 38-284/307.0
AENRGKNRYNNVLPYDISRVKLSVQT-HSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQgrTKCEEYWPSKQAQDY
..|. | | . |   | ||||| ..    .||.| ||.. |     .|| .| || || .||||||....|  |.|||  .|    .|| |||  ...  
dnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdsl

GDITVAMTSEIV-LPEWTIRDFTVKNIQTSESHpLRQFHFTSWpDHGVPDTTDLLINFRYLvRDYMKQSppeSPILVHCSAGVGRTGTFIAIDRLIYQIE
  .  ..  | . . . .   |.| ...   ..   . .   |    |  ..|.   .| | |   . |    |..|..  || ...|..||.  . .. 
vtvpGslrienlkvdskadplfrvtklklvGgd.deerflehw.qgdvnnssdvysplrvl.rklrnls...kpvvvqdilGvskaatlvaieiallsll

NENTV--DVYGIVYDLRMHRPLMVQTEDQYVFLNQCVL----DIVRSQKDSKVDL
   ..   |   |  ||..|.| |..  .|.|. . ||    |.. | |.  || 
rGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsakeldvdy
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1064-1296 9e-64 209.9 In-house 2-236 (237) alignment 
Range on Protein: 1064-1296
Range on HMM: 2-236/237.0
ENRGKNRYNNVLPYDISRVKLSVQThSTDDYINANYMPGYHS-KKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPS-KQAQDY
||. |||| |.  || ||| |     |. |||||.|. |.    | .||.|||| .. .|||.|||...   |.|||  .|. . || .|||| .| . |
enkiknrygnivaydhsrvvlkgag.sgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GDITVAMTSEIVLPEWTIRDFTVK-NIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIE
| .||... .  . ..|.| ...  ...  |   . |..||||||.|||. |  |. ||  . .  .  .  .| ..|||||||||| |. || .. | .
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

NENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVL
... ||.|  || .   || ..||.|||||..| .|
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_PTPN23_pd Subfamily PTPN23 1064-1303 2.5e-63 208.6 In-house 42-284 (288) alignment 
Range on Protein: 1064-1303
Range on HMM: 42-284/288.0
ENRGKNRYNNVLPYDISRVKLSvqtHSTDDYINANYMPGYHSK-KDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSK--QAQD
 .  |||....|||| .||||     |.|||||| .. .  .   ||||||.||..|| |||.||.|. .  |.||..  |.|..|...|||..  ... 
lyseknrsrdilPyDhnRvklr...gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvk

YGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRD--YMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQ
.||..|.. |.  ....  |.....  .... . ..  ..||||..|||.. . |..|   |..  . .| . . |..|||||||||||.|  .   . .
fgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavre

IENENT-VDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQK
.|..|  .|.  .|  ||  |  |||...|. |. . ||  .|   
lekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvl
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1064-1303 3.6e-39 129.1 In-house 36-273 (281) alignment 
Range on Protein: 1064-1303
Range on HMM: 36-273/281.0
ENRGKNRYNNVLPYDISRVKLSV--QTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQ--AQ
 |  |||| |.   |||||.| |    . . ||| |||.     |. .| ||||  .|  |||||.|..|  ||.|| . .|  | || ||.| .   . 
vnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahccl

DYGDITVAMTSEIVLPEWTIrdFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRdymKQS-PPespiLVHCSAGVGRTGTFIAIDRLIYQ
..  ..|.     |          ..     |.. . .. .  |||  ||........    .|    .| ||    ..||||||||.||..|..  .  
qfdklsvsyedstvnkslvt..trlnlsyegetrlithwlwkewpdwqvpessevmlkilrkir...arstpp....vihcsagvgrsgtlmaveialqs

IENENTV-DVYGIVYDLRM-HRPLMVQTEDQYVFLNQCVLDIVRSQK
| .  |. |.  ||  ||.  |   ||| .||... . .||.  . |
ihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgvayk
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1064-1171 4.5e-28 93.0 In-house 46-165 (350) alignment 
Range on Protein: 1064-1171
Range on HMM: 46-165/350.0
ENRGKNRYNNVLPYDISRVKLS---------VQTHSTDDYINANYM----PGYHSKKDF--IATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTK
|   ||||.|.|||. |||||            ..||.|||||||.    .. . . ||  ||||.|||.|..||.... . .|  |..||. ||... |
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CEEYWPSkqaQDYGDITVAMTSE
|..||.     .| |||| ..| 
cyrYWqe...gsydditvklask
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1064-1168 1.1e-18 61.7 In-house 47-165 (349) alignment 
Range on Protein: 1064-1168
Range on HMM: 47-165/349.0
ENRGKNRYNNVLPYDISRVKLSV-------QTHS--------TDDYINANYM--PGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGR
|   ||||...|||. |||||           .|         ||||||||.  . .  .| .|||| ||| |..||....  ..|  .. |..  |.. 
elfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsl

TKCEEYWpskQAQDYGDITVAM
 ||. ||   |  .| .||| .
ekcdiyw...qelsysnitvkl
subfamily_eak_pd Subfamily eak 1064-1216 1.4e-16 54.8 In-house 51-202 (332) alignment 
Range on Protein: 1064-1216
Range on HMM: 51-202/332.0
ENRGKNrYNNVLPYDISRVKLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQ--AQDY
|.  .|   ...|||   |.|.      . ||||  .   .  . .| |  .  . .  ||.|| |..  ||..| . ||..  | . |.| |     ..
eavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkf

GDITVAMTSEIVLPEWTIRDFTVKniQTSESHPLRQFHFTSWPDHGVPDTTDLLI
| . |   . .       | . ..  .  |.| .  ...  | .  .|   |.| 
Gildverkefvkrniletrllels..kGnethrvlhykvfGwtettlpkyedfla
Y_phosphatase Protein-tyrosine phosphatase 1065-1296 4.3e-85 280.2 Pfam-A 1-234 (235) alignment 
Range on Protein: 1065-1296
Range on HMM: 1-234/235.0
NRGKNRYNNVLPYDISRVKLSVQTHSTDdYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWP--SKQAQDYG
|. ||||...|||| .||||. .....| ||||||. ||..|| ||||||||..|..|||||||...| .|.|||...|.||.||..|||  ... . ||
nkkknRykdilpydktrvklkgsegpsd.YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

DITVAMT-SEI-VLPEWTIRDFTVKNIQTS-ESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMkqSPPESPILVHCSAGVGRTGTFIAIDRLIYQI
||.| .. .|     |.|.|....|. ... |.. ..|.|.|.|||||||.... |...   |. .   .. ..|..|||||||||||||.|.| |. |.
dikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldilleql

ENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVL
|.|..|||. ||  || .|| |||...||.|| ...|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 1065-1296 4.3e-85 280.2 In-house 1-234 (235) alignment 
Range on Protein: 1065-1296
Range on HMM: 1-234/235.0
NRGKNRYNNVLPYDISRVKLSVQTHSTDdYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWP--SKQAQDYG
|. ||||...|||| .||||. .....| ||||||. ||..|| ||||||||..|..|||||||...| .|.|||...|.||.||..|||  ... . ||
nkkknRykdilpydktrvklkgsegpsd.YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

DITVAMT-SEI-VLPEWTIRDFTVKNIQTS-ESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMkqSPPESPILVHCSAGVGRTGTFIAIDRLIYQI
||.| .. .|     |.|.|....|. ... |.. ..|.|.|.|||||||.... |...   |. .   .. ..|..|||||||||||||.|.| |. |.
dikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldilleql

ENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVL
|.|..|||. ||  || .|| |||...||.|| ...|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail
0041856 (Phosphotyrosine protein) phosphatases II 1065-1301 1.8e-54 179.4 In-house 1-173 (182) alignment 
Range on Protein: 1065-1301
Range on HMM: 1-173/182.0
NRGKNRYNNVLPYDISRvklsvqthsTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTkcveqgrtkCEEYWPskqaqdygdi
|. |||| ..|||| ||           ||||||.. |..  ..||||||||..|. ||.||..| .. .|..||         .| |||          
nldknrysdilpydhsr.........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp..........

tvamtseivlpewtirdftvkniqTSESHPLRQFHFTSWPDHGVPDtTDLLINFRYLVRDymkqspPESPILVHCSAGVGRTGTFIAIDRLIYQienenT
                        . . .   |.....|||||||| .| |..|   |..      .. |.|||||||||||||..|.. ....      
........................ellerlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaaylmkkl.....g

VDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRS
|... .|  .|..|| ||.|..||.|| ...|.... 
vsleeavklvrsrRpgmvitpnqyfflqlallellll
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1065-1301 3.7e-39 129.2 In-house 55-291 (305) alignment 
Range on Protein: 1065-1301
Range on HMM: 55-291/305.0
NRGKNRYNNVLPYDISRVKLSVQThsTDDYINANYMPG-YHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYG-
.  ||||..|   | | |||.  .    ||| |||.      .| ||..|||| .|. .|| || ...|  |.|| | || |. || .|||  | .    
aitknryqdvpcqdqsavkldkps..psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklel

--DITVAMTSEI-VLPEWTIRDFTVKNIQT--SESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDymkqSppESPILVHCSAGVGRTGTFIAIDRLIY
   | |   |    .   .  . |. |.    ...  .|....| ||| |||      ...   .|     |  . ||.||||||.||||| .||. .. 
ksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairg....s..kvpivvhcsagigrtgtivaieyile

QI-ENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRS
.| || .   .  .|  || .|   .|.. ||.|. . .|. .  
kiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfle
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1066-1309 5e-37 122.3 In-house 51-289 (301) alignment 
Range on Protein: 1066-1309
Range on HMM: 51-289/301.0
RGKNRYNNVlPYDISrVKLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDY--G-
. |.||..| | . |   . | .. .   | ||..|     . ||||||||.|| .||| |.   .|  |.||.. ||.  .||||| |.| ...   | 
kdkhryptv.PckPs.tavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr

-DITVAMTSEIVLPEWTIRDFTVKNIQ-TSESHPLRQFHFTSWPDHGVPDTTDLLINFRylvrDYMKQSppESPILVHCSAGVGRTGTFIAIDRLIYQIE
 .|..  .  |.  . . | . |..     ... .  . ...|.|.||| .   | ..     . .|.|  | ||.||||||.||. .||. . |  ..|
fkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlm....elvkks..ekPivvhcsaGiGrsvafigteylareve

NENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNqcVLDIVRSQKDSKVDL
...|...   . .|| ||   |||. |  ...  .  . |  |.  .|.
adptieltealkhlrehrwngvqtnsqlywmt..lGtvyrlikeygfdm
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1066-1304 3.6e-30 99.7 In-house 44-281 (312) alignment 
Range on Protein: 1066-1304
Range on HMM: 44-281/312.0
RGKNRYNNVLPYDISRVKLSVQthsTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQA-QDYGDI
.  ||| |.  .|  |  |. .    . || ||..      . |..||||| ||   ||...      .||.|.  ||.|  || .|     .  |  | 
kdlnrypniqcwdrgrftlagd...enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledh

TV--AMTSEIVLP-----EWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRdymKQsppESPILVHCSAGVGRTGTFIAIDRLIY
 |   . .|| .        | | . |    | .   | .. ..||||||.||. |    .   |.   |.     |.. |||||||||||.. |. .| 
rvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavk...kd...kkpviahcsagvgrtgtlaliesmia

QIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKD
 .      .|  .   ||  |   |..  |||.  .|||... |.  
alrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1067-1299 1.1e-44 147.5 In-house 35-295 (297) alignment 
Range on Protein: 1067-1299
Range on HMM: 35-295/297.0
GKNRYNNVLPYDISRVKLSvQTHSTDDYINANYM--PGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSK--QAQDYG
 ||||...| .| .||||  .. .  |||||.|.  |  ...  .| .|||| .|..|||..|.|..| .|.|..|  |.|| ||  ||||   . .  |
rknryrdilatddtrvkll.rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkag

DITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVP-DTTDL-------------------LIN-F---RYL-VRDYMKQSPPESPILV
|. |   |.      ..    .. |  |||  .|   | |||||||| |  ||                   |.. |    .| .  .  . | . ..||
dvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprnayllv

HCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIV
||||||||.|  .  | .. .. ..   ||  |.  ||  |. .||| .|. .| . ||  .
hcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1067-1208 3.3e-15 50.4 In-house 98-235 (244) alignment 
Range on Protein: 1067-1208
Range on HMM: 98-235/244.0
GKNRYNNVLPYDISRVKLSVQThSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKcVEQGrtkcEEYWPSKQAQDY--GDI
 |||    ||.|..|| ||  .   . |||| ..       ..| || || .|  |||.|. |. |  ...|   ||.     .||||  .  ..   ||
wknregaglpfdfnrvplskgs.mgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgs.veee....deywpdseplewyeedi

TVAMTSEIVLPEWTIRDFTVKNiQTSESH-PLRQFHFTSWPDHGV
||..|    . .    .. ..  .  |||  |  |  . ||  | 
tvtltdrdefknikasnleies.dmneshqaltmfqisnwpsdgt
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1068-1299 2.6e-19 64.4 In-house 22-257 (290) alignment 
Range on Protein: 1068-1299
Range on HMM: 22-257/290.0
KNRYNNVLPYDiSRVKLSV-QTHSTDDYINANYMPgYHSKKDFIATQGPLPNT-------LKDFWRMVWEKNVYAIIMLTKCVEQGRT----KCEEYWPS
..|... |  . .|| | .  .. .|||| ||..  . .   .|.|| |. ..       ...|| |. . .|  ..|| .  |. .      |..| | 
dqRlevpLvea.trvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpe

KQA--QDYGDITVAMTSEIVLPEWTIRDFTVKnIQTSESHPLRQFHFTSWPDHGVPDTTDLLINfryLVrDYMKQSppESPILVHCSAGVGRTGTFIAID
.      ....||  .| .   .  .|  .||  .  | . .    . .| .  |...| .|..   |. ...|.|  ..|..|||  |. |  .. ||.
svgeelkfkgltvkCkskekeddvetRelvvk.fddeeeftvtHsllkgWnklnvqedtktlls...li.qkvkas..ktpvivHcvdGiSrsAalaaii

rLIYQI--ENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLdiV
 | ||   | .. | .  ....|| .| |..... .. |    ..  .
.lgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv..l
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1075-1207 1.2e-11 39.0 In-house 3-125 (130) alignment 
Range on Protein: 1075-1207
Range on HMM: 3-125/130.0
LPYDISRVKlsvqthsTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKcVEQGrtkcEEYWPSKQAQD--YGDITVAMTSEI
|....||..        ..||||...      .... || || .|  |||.|. |. |  ...|   ||.     .||||  .  .    ||.|..|   
lefevsrlq.......gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgs.veee....deywpdsePlewyeediivtltdrd

VLPEWTIRDFTVKNiQTSESH-PLRQFHFTSWPDHG
   .     . ... .  |||  |  |. . ||  |
efknikasnleies.dlneshqaltmfqisnwpsdg
0044763 (Phosphotyrosine protein) phosphatases II 1087-1294 1.5e-34 114.5 In-house 13-166 (178) alignment 
Range on Protein: 1087-1294
Range on HMM: 13-166/178.0
QTHSTDDYINANYMPGYhskkdFIATQGPLpntlKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAqdygditvamtseivlpewtirdftvkn
. . . |||||... ..     ..... |      |......| .. .|..||. .| |. || .|||..                              
eglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag............................

iqtseshplRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPpeSPILVHCSAGVGRTGTFIAIDRLIYQienenTVDVYGIVYDLRMHRPlMVQTED
          |.... .||||||| .. . .|  ..........  .|.||||||||||.||..|.. ....      .... ..  .|..|| .|....
.........iqylhipipDhgvpdllehflefvefieealdekg..gpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpg

QYVFLNQC
|. .| ..
qlrqLyef
0051429 (Phosphotyrosine protein) phosphatases II 1091-1311 8.1e-58 191.4 In-house 3-237 (272) alignment 
Range on Protein: 1091-1311
Range on HMM: 3-237/272.0
TDDYINANYMPGYHS---KKDFIATQGPLPNTLKDFWRMvWEKNVYAIIMLTKCVEQGRTKCEEYWP------------SKQAQDYGDITVAMTSEIVLP
...||||....||..   .. .....||||.| .||||. .| .. .|..|....|.|| ||. |||            | .   ||...| ..||..|.
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

EWTIRDFTVKNI-QTSESHPLRQFHFTSWPDHGVPDTTdlLINFRYLVRDymkqsppESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVD--------
 ...| ...... ...|.. ....|.|.|||||||. .  |...  |..|       . |.|||||||..||||..|...|..... |  ||        
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

VYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDSKVDLIY
....|  || .|| .||||.||.|| ...|...||  ..... . 
leeaveelraqrpgavqteeqylflyeallellrsllsvraeyll
0043147 (Phosphotyrosine protein) phosphatases II 1091-1293 1.6e-47 156.7 In-house 4-155 (172) alignment 
Range on Protein: 1091-1293
Range on HMM: 4-155/172.0
TDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCveqgrtkceeywpskqaqdygditvamtseivlpewtirdftvKNIQTS
 .|||||.|...|.  ..||||||||.||| |||||..|... .|..||..                                            .. . 
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpel

ESHPLRQFHFTSWPDHGVPdTTDLLINFRYLVRDYMkQSPPESPILVHCSAGVGRTGTFIAIDRLIyqieneNTVDVYGIVYDLRMHRPLMVQTEDQYVF
...   |.....||||||| ...||..|  ...... .  |. |.|||||||||||||..|.. ..        .... .|  .|..|| .||...|| |
lerlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrf

LNQ
| .
lyy
0036282 (Phosphotyrosine protein) phosphatases II 1092-1293 2.8e-53 175.5 In-house 2-164 (174) alignment 
Range on Protein: 1092-1293
Range on HMM: 2-164/174.0
DDYINANYMPGYHSKKDFIATQGPLPntlkdFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSkqaqdygditvamtseivlpewtirdftvknIQTSE
.|||||... ...  . .||.||||.     ||.|..| .. ...||....| |..||  |||.                                ....
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredl

SHPLRQFHFTSWPDHGVPDTTDlLINFRYLVRDYMKQsPPESPILVHCSAGVGRTGTFIAIDRLIYQIEnENTVDVYGIVYDLRMHRPLMVQTEDQYVFL
..   |.... ||||||||..  |..|  .|...... .|. |.|||||||||||||..|......... |..||.. .|. ||..|| ||||..|| ||
erlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

NQ
 .
yy
0046846 (Phosphotyrosine protein) phosphatases II 1092-1296 3e-47 155.9 In-house 12-170 (176) alignment 
Range on Protein: 1092-1296
Range on HMM: 12-170/176.0
DDYINANYMPGYHskkdFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYgditvamtseivlpewtirdftvkniqtse
 ||||||.. |..    .||||||||.|| ||..|..| ...|...||..|| || ||  |||  .. ..                              
ldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..............................

shplrQFHFTSWPDHGVPDTtDLLINFRYLVRDYMKQSppeSPILVHCSAGVGRTGTFIAIDrliyQIENENTVDVYGIVYDLRMHRP-LMVQTEDQYVF
     |.... ||||||||  .||...  ..|.. |.     |.|||||||.|||||..|..     .| |. ..|. ... .|..||  .|||..|| |
.....qylhlpwpDhgvpdl.elllellefirealkeg...gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrf

LNQCVL
| ...|
lyefel
0051082 (Phosphotyrosine protein) phosphatases II 1092-1295 4.3e-39 128.8 In-house 3-149 (151) alignment 
Range on Protein: 1092-1295
Range on HMM: 3-149/151.0
DDYINANYMPGYhskkdFIATQGPLPntlkDFWRMVWEKNVYAIIMLTKCVEQGrtKCEEYWPSKQaqdygditvamtseivlpewtirdftvkniqtse
.||||..|. |.     .....|||.    ||.....| ....|..|.. .| |  .| ||.|. .                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

sHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDymkqsPPESPILVHCSAGVGRTGTFIAIDRLIYQienentVDVYGIVYDLRMHRPLMVQTEDQYVFL
 . ........|||.|.|...| ...|  |..|     ... |.|||||||.|||||..|.......      |... .. ..|..|| .||...|..|.
.ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfq

NQCV
 ...
lfal
0049260 (Phosphotyrosine protein) phosphatases II 1099-1293 1.5e-45 150.0 In-house 1-144 (152) alignment 
Range on Protein: 1099-1293
Range on HMM: 1-144/152.0
YMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWpskqaqdygditvamtseivlpewtirdftvkniqtseshplrQF
...||. .. |||||||.||||.|||||..| .. .|.|||...| |. |||.|.                                           |.
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

HFTSWPDHGVPDTTDLLINFRYLVRDYmkQSPPESPILVHCSAGVGRTGTFIAIDRLIyqieneNTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQ
... |||||||| ..||. .  ... .  .  .. |.|||||||||||||..|.. ..      . |... .|  .|..|| .|....|. || .
lhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1100-1297 2.6e-22 73.7 In-house 83-286 (302) alignment 
Range on Protein: 1100-1297
Range on HMM: 83-286/302.0
MPGYHSKKDFI-ATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQA--QDYGDITVAMTS-EIVLPEWTI-RDFTVKNIQT-----
| |   |..       |  .||. .| .. . ||  .. |.. ||..  || ||.  |      .|  ||   | .  | |.|  ..|.. ...      
mdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekk

--SESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQsppespILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQ
     ...  ..|..||||| |. ..  ..       | |.      .|||||||||||||..||   |    .... |.  ||  .|  |   ||.|.|
kkkvkktvdilafsawpdhGapkeaytaldilkfcesykkn......vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqq

YVFLNQCVLD
 ..|  ||  
liylllcvtk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1102-1167 2.8e-10 34.1 In-house 231-294 (440) alignment 
Range on Protein: 1102-1167
Range on HMM: 231-294/440.0
GYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQgrtKCEEYWPSK-QAQDYGDITVA
||  |. ||||| ||  |. ||||.| . .. .|||| .  ..    |  ||| . ..  .| .|| 
gyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvg
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1105-1293 3.1e-23 77.0 In-house 3-198 (199) alignment 
Range on Protein: 1105-1293
Range on HMM: 3-198/199.0
SKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQA--QDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSE--SHPLRQFHF
... .|||| || .|. |||.||||     |.|.     .  .    |||. ..    || ..|.  .  . |..||  . . |  |.   .  . .. |
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TSWPDHGVPDTTdLLINFRYLVRDYMKQSPP--ESPILVHCSAGVGRTGTFIAIDRLIYQIENENT--VDVYGIVYDLRMHRPLMVQTEDQYVFLNQ
||| ..  |. . |.. |    |.  |.     ..|..|||| | | || |.|.|  .   |. .|  ||.. .   ||  |  .. . ..| |. |
tswkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1106-1293 4.1e-23 76.6 In-house 3-197 (198) alignment 
Range on Protein: 1106-1293
Range on HMM: 3-197/198.0
KKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQA--QDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSE--SHPLRQFHFT
.. .|||| || .|| |||.||||     |.|.     .  .    |||. ..    || ..|.  .  . |..||  . . |  |.   .  . .. ||
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWPDHGVPDTTdLLINFRYLVRDYMKQSPP--ESPILVHCSAGVGRTGTFIAIDRLIYQIENENT--VDVYGIVYDLRMHRPLMVQTEDQYVFLNQ
|| ..  |. . |.. |    |.  |.     ..|..|||| | | || |.|.|  .   |. .|  ||.. .   ||  |  .. . ..| |. |
swkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1113-1305 4.5e-19 63.5 In-house 39-229 (255) alignment 
Range on Protein: 1113-1305
Range on HMM: 39-229/255.0
QgplpnTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQ--AQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPD
      |.. |....  ..   ..||.   |.|. ||..|.| ..   . . |..|. |  .  .    .. | .  .  . | .. .... |...  |.
l.....tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPe

TTDLLINFRYLVRDymkqSppeSPILVHCSAGVGRTGTFIAIDrLIYQ-----IENENTVDV--YGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIV--RS
 .  . |   .|||    |    ...||||.|.||. .|. .. |.||     ... .||..    .. .|| .|.  ..|  |  |    |||.|  ..
lareilnilkvvrd....s...ksvvvhCstGiGrsaafvlae.lvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfpkg

QKDS
. . 
elea
subfamily_hpo-7_pd Subfamily hpo-7 1116-1302 3.8e-16 53.8 In-house 43-230 (263) alignment 
Range on Protein: 1116-1302
Range on HMM: 43-230/263.0
LPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQ--AQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTD
| .|.. |....  ..   ..||.   |.|. ||..|.| ..   | . ...|. |  .  .    ....    .  . | .... .. |...  |  . 
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelar

LLINFRYLVRDYmKqsppesPILVHCSAGVGRTGTFIAIDrLIYQ-----IENENTVDV--YGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQ
  .|   ..|.  |      .. ||||.|.||.  |  .. |.||     ... .||..    .. .|| .|.  ..|  |  |    |||.|  .
eilnilkvarns.k......slvvhcstGiGrsaafsvaE.lvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnn
0048076 (Phosphotyrosine protein) phosphatases II 1171-1296 2.4e-28 94.0 In-house 22-140 (145) alignment 
Range on Protein: 1171-1296
Range on HMM: 22-140/145.0
EIVLPEWTIRD-FTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSppeSPILVHCSAGVGRTGTFIAIDRLIYqieneNTVDVYG
   | .. |.  ... . .. ...   |.....|||||||| ..||..|  ......|.     |.|||||||||||||..|.. ...     . |... 
lellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg...gpvlVHCsaGvgRtgtlvaaylmll.....lgvslee

IVYDLRMHRPLMVQTEDQYVFLNQCVL
..  .|..|| .|....|. || ...|
alelvrsqrpgavpnpgqlrflyefel
0048179 (Phosphotyrosine protein) phosphatases II 1177-1293 4.7e-27 89.9 In-house 31-139 (144) alignment 
Range on Protein: 1177-1293
Range on HMM: 31-139/144.0
WTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKqspPESPILVHCSAGVGRTGTFIAIDRLIyqienENTVDVYGIVYDLRM
.|. ..| .  .... ..  |.....|||||||| ..||..|  .......   .. |.|||||||||||||..|.....     .. .... ... .|.
ttvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrs

HRPLMVQTEDQYVFLNQ
.|| .|....|. || .
rrpgavpnpgqlrfLle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1187-1299 2.1e-21 70.8 In-house 83-194 (440) alignment 
Range on Protein: 1187-1299
Range on HMM: 83-194/440.0
IQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSpPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTED
|.  ||. |.|.|. .|||.|||  .  ....   | .  ...  ..|.|||||||.||||  ||.| .. . .  . .|.. ..  .|  || |||| .
ingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqeka.gngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpe

QYVFLNQCVLDIV
||.|....||. .
qyafvheavlegl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1191-1304 2.4e-15 51.1 In-house 213-349 (350) alignment 
Range on Protein: 1191-1304
Range on HMM: 213-349/350.0
ESHPLRQFHFTSWPDHGVP-DTTDLLINFR--------YLVRDYMkQSPPESPILVHCSAGVGRTGTFIAIDRLIY------QIENE-N-------TVD-
. . . |...  |.| ..  .  ..|  .            . .. ..   ||||||||||||||||....| |.       ....| .       | | 
dPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshl.dnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDl

VYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKD
.  ||  ||  |  |||. ||..|. ...|   . .||
isiivnelrkqrismvqnldqfifiYeallfyfaLrkd
PTPc_DSPc_SM00012 1195-1296 4.8e-35 115.3 In-house 2-104 (105) alignment 
Range on Protein: 1195-1296
Range on HMM: 2-104/105.0
LRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENE-NTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQ
....|.|.|||||||...| ....   |.. ...|  ..|..|||||||||||||.|.| |. |.|.| ..||.. ||  ||..|| |||||.||.|| .
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

CVL
..|
all
PTEN_1 1197-1251 3.6e-09 31.7 In-house 96-149 (196) alignment 
Range on Protein: 1197-1251
Range on HMM: 96-149/196.0
QFHFTSWPDHGVPDTtDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIA
...  ...|||.|.  . |. . . . ..... |..  .|||| ||.||.|| .|
eylhfpieDhgapsl.selfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
0038934 (Phosphotyrosine protein) phosphatases II 1198-1291 8.9e-12 40.5 In-house 82-169 (194) alignment 
Range on Protein: 1198-1291
Range on HMM: 82-169/194.0
FHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPpESPILVHCSAGVGRTGTFIAIdrliYQIENENTvDVYGIVYDLRMHRPLMVQTEDQYVFL
..   .||.|.. ....| .|  || ......| .  ..||| ||.|||||..|     | |.  .  ..   .. .|. || .... |..  |
ylklpfpddgtvPsleillrfldlvdeflnedp.ggvvaVHCkaGlgRtGtlvaa....YLiyrlgm.saeeAialfrekRpgaipnqdyleal
subfamily_PTPDC1_pd Subfamily PTPDC1 1198-1294 9.2e-08 26.7 In-house 85-171 (182) alignment 
Range on Protein: 1198-1294
Range on HMM: 85-171/182.0
FHFTSWPDHGVPDTTDLLInfryLVRdYMKQSPPESPILVHCSAGVGRTGTFIAIdRLIYQieneNTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQC
..  .|.|.||.  . .|     .|.  ....  |  . ||| || ||||  ||   |.|.    . ..    .  .| .||  .|| .|  .... 
vynfgwkDygvasleriLd....ivk.vvafalqegkvavhChaGlGrtGvliac.ylvya....krltaekaiklvrskrpksiqtreqvelvkef
0048567 (Phosphotyrosine protein) phosphatases II 1198-1258 4.2e-07 24.5 In-house 40-103 (157) alignment 
Range on Protein: 1198-1258
Range on HMM: 40-103/157.0
FHFTSWPDHGvPDTTDLLINFRYLVRDYMKQSP-PESPILVHCSAGV---GRTGTFIAIDRLIYQ
.... . |.| | . ..|..| ... ...|.    . .| |||.||    |||.|.|.   ....
vyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhl
subfamily_PTEN_pd Subfamily PTEN 1200-1276 2.7e-06 22.5 In-house 84-157 (184) alignment 
Range on Protein: 1200-1276
Range on HMM: 84-157/184.0
FTSWPDHGVPdTTDLLINFRYLVRDYMKQSPpESPILVHCSAGVGRTGTFIAIdRLIYQIENENTVDVYGIVYDLRM
 .   ||  | . .|| ..   ......... .  . ||| || ||||. |.   |...   |.. ..  .    |.
vypfdDhnpp.plelleeivediekwleedk.knvvvvHCkaGkGRtGvliva.yllkslllekaeealelfaeaRt
subfamily_VSP_pd Subfamily VSP 1204-1251 5.5e-06 20.5 In-house 102-147 (212) alignment 
Range on Protein: 1204-1251
Range on HMM: 102-147/212.0
PDHGVPDTTDLLiNFRYLVRDYMKQSPpESPILVHCSAGVGRTGTFIA
 || ||   .|| .|   |...... . .  . .||  | ||||| . 
ddhnvpkleell.vftkevkewlekdl.knvlaihckGGkgrtGtivc
subfamily_eak_pd Subfamily eak 1218-1305 2.6e-08 27.6 In-house 223-311 (332) alignment 
Range on Protein: 1218-1305
Range on HMM: 223-311/332.0
FRYLVRDYMKQSPPESPIlVHCSAGVGRTGTFIAIDRLIYQIENE--NTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDS
.. ... |..  |  .|| . .. |  |.|.|. || ||  |.|   |.  |  ..   . .|   | .. |. |. . ||| .. ... 
lsstlkkyihtppsfapi.iqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnr
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1228-1303 2.5e-09 31.0 In-house 261-348 (349) alignment 
Range on Protein: 1228-1303
Range on HMM: 261-348/349.0
QSPPESPILVHCSAGVGRTGTFIAIDRLIY----QIENENTVDVY--------GIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQK
..   |..||||||| ||||... .| |.       .. | ...          ||  ||  |  |||   |.... ...|  .. .|
dtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyfalkk
subfamily_CG42327_pd Subfamily CG42327 1232-1294 1.6e-14 48.3 In-house 247-310 (319) alignment 
Range on Protein: 1232-1294
Range on HMM: 247-310/319.0
ESPILVHCSAGVGRTGTFIAIDRLIYQIENE-NTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQC
  |. |||| ||||||. || |  | ..|.  ..||.  .|. .|  |   |.| .|| |. . 
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1236-1297 5.5e-15 49.5 In-house 2-63 (69) alignment 
Range on Protein: 1236-1297
Range on HMM: 2-63/69.0
LVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD
.||||.| |||||||||   . .|  |  ||..  |  .|  ||.||  | .|.|.   . .
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalve
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1237-1297 1e-14 48.6 In-house 2-62 (69) alignment 
Range on Protein: 1237-1297
Range on HMM: 2-62/69.0
VHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLD
||||.| |||||||||   . .|  |  ||..  |  .|  ||.||  |..|.|. . . .
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalve