Gene PTPRQ in Homo sapiens

Synonym: DFNB84, DFNB84A, PTPGMC1, R-PTP-Q, PTPRQ

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRB
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP094_AA protein Get Run
HsapP094_AA_1985-2261 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
fn3 Fibronectin type III domain 61-143 3.1e-13 42.8 Pfam-A 5-85 (85) alignment
Range on Protein: 61-143
Range on HMM: 5-85/85.0
FLAGERVGSAGILLSWNTPPNPNGRIISYIVKYKEV-CPWmqtvYTQVRSKPDSL-EVLLTNLNPGTTYEIKVAAENSAGIGVFS
 |  . |.|  . |||. |....| | .| |.|.|.  ..    ... .. | .  .| ||.|.|||.||..|.| | || | .|
nlsvsevtstsltlsWsppkdgggpitgYeveyrekggge....ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS

fn3 Fibronectin type III domain 308-386 1.8e-07 24.4 Pfam-A 2-85 (85) alignment
Range on Protein: 308-386
Range on HMM: 2-85/85.0
PPQNCVTGNITGKSFSILWDPPTIVTGKF-SYRVELYGP-SGR--ILDNSTKDL-KFAFTNLTPFTMYDVYIAAETSAGTGPKS
.|.|    ..|  |... |.||.   |.. .|.||.    .|.     . ...   . .|.|.| | | . ..| . ||.|| |
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS

fn3 Fibronectin type III domain 399-436 8.1e-06 19.1 Pfam-A 2-39 (85) alignment
Range on Protein: 399-436
Range on HMM: 2-39/85.0
AVFDLQLAEVESTQVRITWKKPRQPNGIINQYRVKVLV
|. .|.. || ||.....|..|....| |  |.|..  
aPenlsvsevtstsltlsWsppkdgggpitgYeveyre

fn3 Fibronectin type III domain 575-650 2e-13 43.5 Pfam-A 6-84 (85) alignment
Range on Protein: 575-650
Range on HMM: 6-84/85.0
INYKNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNR-AFQITTIDNS--FLITGLKKYTKYKMRVAASTHVGESSL
.. ....|.|. | |.||. ..|.||.|..   | ....   ..|.  ..  . .|||| .|.|..||.| . .||.  
lsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe

fn3 Fibronectin type III domain 667-742 1.9e-14 46.8 Pfam-A 1-81 (85) alignment
Range on Protein: 667-742
Range on HMM: 1-81/85.0
SSPQDVEVIDVTADEIRLKWSPPEKPNGIIIAYEVLYKNIDTL----YMKNTSTT-DIILRNLRPHTLYNISVRSYTRFGH
|.|... |..||.....|.||||....| |  ||| |.. ..       ....||   .|..|.|.| |...|..... | 
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngage

fn3 Fibronectin type III domain 761-842 7.7e-12 38.4 Pfam-A 1-85 (85) alignment
Range on Protein: 761-842
Range on HMM: 1-85/85.0
SAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNE-ERTINTTSLT--QNIKVLKKYTQYIIEVSASTLKGEGVRS
|||||.. ....| ...||. ||....| |..|.. .. ..|.| ........ |   ... || .|.| ..| | . .||| .|
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS

fn3 Fibronectin type III domain 856-933 1.7e-11 37.3 Pfam-A 1-83 (85) alignment
Range on Protein: 856-933
Range on HMM: 1-83/85.0
SPPQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYVWNR--SS-LKTINVTETS--LELSDLDYNVEYSAYVTASTRFGDGK
|.|...||.. .  .. |||.|| ...| | .|.| ...   ..  |...|..|.  ..|..|  . ||.  |.| .. | |.
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegp

fn3 Fibronectin type III domain 950-1040 1.2e-09 31.3 Pfam-A 1-85 (85) alignment
Range on Protein: 950-1040
Range on HMM: 1-85/85.0
DPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSVYYRNTSGTFmqnftlHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNGNKS
..|...   . .|.|. | |.||....| |..|.| ||...|.       .... . .. | | .. .|.  . |.|...| . .|.|  |
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge......ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS

fn3 Fibronectin type III domain 1058-1132 3.4e-06 20.3 Pfam-A 4-80 (85) alignment
Range on Protein: 1058-1132
Range on HMM: 4-80/85.0
GNLTYESISSTAINVSWVPPA-QPNGLVFYYVSLILQQTPR-HVRPPLVTYERSIYFDNLEKYTDYILKITPSTEKG
.||. ....|| ...|| ||. .   .. | | .  ..... ...  .   ..|  . .|. .|.| ....  ...|
enlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngag

fn3 Fibronectin type III domain 1158-1231 2e-10 33.8 Pfam-A 7-85 (85) alignment
Range on Protein: 1158-1231
Range on HMM: 7-85/85.0
TFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQGPNEN---YSFITSDNY--IILEELSPFTLYSFFAAARTRKGLGPSS
.... .|||. |||.|| ...| | .|.....  ...    .| .. .    .|..| | | |.|  .|....| ||.|
svsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS

fn3 Fibronectin type III domain 1245-1325 2.6e-11 36.7 Pfam-A 2-83 (85) alignment
Range on Protein: 1245-1325
Range on HMM: 2-83/85.0
PPQNLTLINCTSDFVWLKWSPSPLPGGIVKVYSFKIHEHETDT-IYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGN
.|.||.... ||. . |.|||.. .|| .. |. .  | ..      ..... .|...| ||.| ..|..|| | ...|.| 
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegp

fn3 Fibronectin type III domain 1343-1418 4e-12 39.3 Pfam-A 3-85 (85) alignment
Range on Protein: 1343-1418
Range on HMM: 3-85/85.0
VQNMQCMATSWQSVLVKWDPPKKANGIITQYMVTVER-------NSTKVSPQDHMYTFIKLLANTSYVFKVRASTSAGEGDES
..|... ...  |. ..|.|||. .| || | |...        .. .|... . .|. .| ..|.|.|.|.| . |||| ||
PenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS

fn3 Fibronectin type III domain 1431-1526 3.2e-10 33.2 Pfam-A 1-85 (85) alignment
Range on Protein: 1431-1526
Range on HMM: 1-85/85.0
SVPTNIAFSDVQSTSATLTWIRPDTILGYFQNYKITTqlraQ-----KckeweseecveyQKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGNA
| |.|. .|.|.|||.||.|  |..  | ...|...     .     .            .. ..  ... |. |. |||  . |.|.|.| ..||.| .
saPenlsvsevtstsltlsWsppkdgggpitgYevey....rekggge............ewkeftvprtttsvtltgLkpgteYefrVqavngagegpe

S
|
S

fn3 Fibronectin type III domain 1541-1618 2.6e-09 30.3 Pfam-A 2-79 (85) alignment
Range on Protein: 1541-1618
Range on HMM: 2-79/85.0
PPENVHVVATSPFSISISWSEPA-VITGPTCYLIDVKSVDNDEFNISFIKSNEENkTIEIKDLEIFTRYSVVITAFTGN
.|||..| .... |...|||.|.      | | ........ |   .|  .. .. . ....|.  |.|.. ..| .|.
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavnga

fn3 Fibronectin type III domain 1643-1732 8e-10 31.9 Pfam-A 1-83 (85) alignment
Range on Protein: 1643-1732
Range on HMM: 1-83/85.0
DPPNNMTFQKIpdEVTKFQLTFLPPSQPNGNIQVYQALVYREDDPTavqiHNLSIIQKTNTFvIAMLEGLKGGHTYNISVYAVNSAGAGP
..| |...  .    |...|.. ||....|.|. |.  .  ....     .  ..  . .|   ..|.||| | .|...|.||| || ||
saPenlsvsev..tstsltlsWsppkdgggpitgYeveyrekggge....ewkeftvprttt.svtltgLkpgteYefrVqavngagegp

0050432 (Phosphotyrosine protein) phosphatases II 1976-2263 4.2e-97 320.5 In-house 19-302 (308) alignment
Range on Protein: 1976-2263
Range on HMM: 19-302/308.0
YRKSIKPISKKSFLQHVEElcTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLiadaSvPGSDYINASYISGY--LCPNEFI
. .| ...| ...|...|.   ... ...||| ||...  .|. . | || |. |||...| || ..||||    . .|||||||||..||   .|..||
ilvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfI

ATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNK-PVTVFGDIVITKLMEDVQIDWTIRDLKIER--HGDCMTVRQCNFTAWPEHG
|||||||.||.|||||||| . .. ||||...|.||. |.||||.. .  ....|....| | |.|. |.|.| |...    |.  ||..  .|.||.||
atqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhg

VPENSAPLIHFVKLVRASRahDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNK
||.. ..|..|..||| |.  .  |..|||||||||||.|||||.| .... .  ||....|. ||. |..|||.. ||.||....|..|..|
vPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklk

subfamily_PTPRA_pd Subfamily PTPRA 1978-2260 2.6e-79 261.5 In-house 9-295 (330) alignment
Range on Protein: 1978-2260
Range on HMM: 9-295/330.0
KSIKPISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQG
|   |.  . . . ..   ...| .|.|||  ||    . .   |.   |. |||..|| ||. .|| |     |. |||||||.| ||   ..|||.||
kkyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqG

PLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNkpVTVFGDIVITKLMEDVQIDWTIRDLKIERHGDCM------TVRQCNFTAWPEHGV
|.  || |||||.|| .. |.||||.  |. . .|.||||..   .  .|.| ..   | | .|.|.|.. ... .| .       |||  ||.||. ||
PkeetvedfwrmiweqksativmltelkerkeekcaqywPdeG..lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGv

PENSAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLL
| ..  .....| |.. .   . |..||||||||||| ||.|| . . ..    ||... | .||  |  ||| . || |... .|.  
PfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy

subfamily_PTPRB_pd Subfamily PTPRB 1979-2266 1.4e-126 416.5 In-house 3-291 (293) alignment
Range on Protein: 1979-2266
Range on HMM: 3-291/293.0
SIKPISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGP
. |||....| .||........|.|.||..|| .. .| . . |.|..||||||. || ||...|||| | .. .|||||||.||.|| .|.||||||||
kskpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGP

LPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVtVFGDIVITKLMEDVQIDWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSAPL
||.|| ||||||||......|||||..|||...|..|||.|..|| ..||| .| ..|... ||.||.||||.. ....|||..||.||.|||||....|
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv.lyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktl

IHFVKLVRASR--AHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGSN
..||. || .   .....|..|||||||||||.|||||.|.|.|...|.|||.|.|||||.||...||. .||||.|||.||||..| ..
ldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkkeee

0039614 (Phosphotyrosine protein) phosphatases II 1979-2263 9.9e-90 296.3 In-house 10-292 (297) alignment
Range on Protein: 1979-2263
Range on HMM: 10-292/297.0
SIKPISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDlsSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASV-PGSDYINASYISGYLC-PNEFIATQ
.  ||. . . ...  .  |.. ....|| ||...  |   . | ||.|. |||...| ||...||||    .| ..||||||||..|| . ...|||||
esipiplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatq

GPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRiRCHQYWPEDNKpvtVFGDIVITKLMEDVQIDWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSA
||||.||.|||||||| . ...||||...|.||  |.|||||.     ..||...| | ...  ..|.| |.....|   ||..  .| ||.||||....
gPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppsle

PLIHFVKLVRASRAH--DTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNK
 |..|..|||  .|.  . .|..|||||||||||.|||.. . .... .  ||..  |.|||. |...||.. ||.||....|.||..|
llleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk

0045450 (Phosphotyrosine protein) phosphatases II 1980-2262 5.7e-88 290.8 In-house 6-306 (307) alignment
Range on Protein: 1980-2262
Range on HMM: 6-306/307.0
IKPISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQ--DLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASV-PGSDYINASYI--------SGYLC
...|. . .|..| .|  ... ....|| .|...      . . | ||.|. |||...| ||...||||    .  ..||||||||.        .|| .
slfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl

PNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDnKPVTVFGDIVITKLMEDVQIDWTIRDLKIE---RHGDCMTVRQCNFTA
...|||||||||.|| |||||.|| . ...||||...|.||. |.||||.. . . ..|....| | |... ..|.| |...     |   ||..  .|.
krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytg

WPEHGVPENSAPLIHFVKLVRASRAH--DTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDF---VDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLL
||.||||.. ..|..|...||. ...  . .|..|||||||||||.|||.. . ......     ||..  |..||. |...|||. ||.||....|.||
wpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

SN
 .
lk

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1980-2077 1.5e-12 41.5 In-house 2-95 (95) alignment
Range on Protein: 1980-2077
Range on HMM: 2-95/95.0
IKPISKKSFLQHVEELCTNNNLKFQEEFSELPKFlQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADAsvpGSDYINASYISGYLCPNEFIATQG
.|||    |  || |. .| . .|..||  ..      . |      |  |||| || ||.  || | .      |||||| .. ||   | .||.||
fkpihvsvfhshvlemhsnsdqefdnefksismt.sgapytvgsseanipknrflnifpydatrvvlttkr...dsdyinacfvdgyarkncyiaaqg

subfamily_PTPRD_pd Subfamily PTPRD 1981-2284 2.3e-106 351.7 In-house 3-304 (564) alignment
Range on Protein: 1981-2284
Range on HMM: 3-304/564.0
KPISKKSFLQHVEELCTNNNLKFQEEFSELPKFlQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLP
|||. ... .||..| .|..|||.||. .. .  |  . . |. | |.||||. || .|...||.| .   ..||||||||.| ||  ....|||||||.
kpipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

GTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNkpVTVFGDIVITKLMEDVQIDWTIRDLKI--ERHGDCMTVRQCNFTAWPEHGVPENSAPL
 |. |||||||| . .| ||||.. |||. .||.||||..   . .|....|   |    | .||..|.  ... . ..||| .||.||.|||||. ..|
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg..tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatsl

IHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNkgSNQPICFVNY-SAL
..... |||.. .|. |..|||||||||||.||..| . . |.. . ||||. |..||..|  |||.  ||||.|. ||. |.    |. .   |. ..|
LdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealac..gntevesenlkqhl

QKMDSLD
||. . .
qkLaeve

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1981-2263 1.3e-78 259.3 In-house 2-286 (305) alignment
Range on Protein: 1981-2263
Range on HMM: 2-286/305.0
KPISKKSFLQHVEELCTNNNLKFQEEFSELPKFlQDLSSTDADlPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLP
|.|. ... ....|  .... ...... .|..  ..    . .   |.||||. .| .....|..| .. |.. ||||||||. ||   ...|..||||.
kiialddlaayikearvysdkgleaqykslyee.eesidvgkk.eankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlk

GTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKIER---HGDCMTVRQCNFTAWPEHGVPENSAP
 || ||||...|.. .|.||||.  | |. .|.|||||  . .. ||.....   |    |...|.|||       .  || | ..| ||.||||. .. 
ntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfats

LIHFVKLVRASRAHDTT-PMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNK
|....| |. .. .|   |..|||||||||||||||.|   ....  . ||..... .|||.|| |||.|.|| |||. . .|.   
llslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg

0051299 (Phosphotyrosine protein) phosphatases II 1982-2260 9.9e-99 325.7 In-house 4-286 (288) alignment
Range on Protein: 1982-2260
Range on HMM: 4-286/288.0
PISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPG
.|| ...|..|..|. |.. ...||| ||...| ||. . | || |. |||...| ||...||||    .|.||||||||||.|| ....|||||||||.
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn

TVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEdnKPVTVFGDIVITKLMEDVQIDWTIRDLKIE------RHGDCMTVRQCNFTAWPEHGVPENS
||.|||||||| . .. ||||...|.||. |.||||.  . ....|||..| | |.|. |.|.| |...       .| . ||..  .|.||.||||.. 
tvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

APLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLL
 .|..|..||| ..|..  |..|||||||||||.|||||.| .... .  ||....|. ||. |..|||.. ||.|.....|..|
ellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

0043336 (Phosphotyrosine protein) phosphatases II 1982-2259 2.3e-90 298.1 In-house 1-276 (278) alignment
Range on Protein: 1982-2259
Range on HMM: 1-276/278.0
PISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQdLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPG
||| |..|....||  |.. ....|| ||..|    . . | || |. |||...| ||...||||  . ....||||||||..|| .|..|||||||||.
pisvkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe

TVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPednKPVTVFGDIVITKLMEDVQIDWTIRDLKIE--RHGDCMTVRQCNFTAWPEHGVPENSAPLI
||.|||||||| . .|.||||...|.||. |.||||   . ....||...| | |... |.|.|.|...  ..| . ||..  ...||.|||||. ..|.
tvedFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslslll

HFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDL
.|.| ||  .... .|..|||||||||||.||||. | ...... .||..  |.|||. |...||.. ||.||....|..
dflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1982-2265 9.5e-63 207.1 In-house 9-289 (297) alignment
Range on Protein: 1982-2265
Range on HMM: 9-289/297.0
PISKKSFLQHVEElcTNNNLKFQEEFSELPKFlQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCpnEFIATQGPLPG
||    |   |..    .   |.|||  ||.  .  ..| |.   |  |.|. || ||. .||||    . | |||.|||.. |.    ..|.|| | . 
piplsdfatlvqk..nrhtdvfseeflclpea.niqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmka

TVGDFWRMVWETRAKTLVMLTQCFEKGRiRCHQYWPEDNkpVTVFGDIVITKLMEDVQIDWTIRDLKIERHG--DCMTVRQCNFTAWPEHGVPE--NSAP
|| |||.||.. ...|.|||..  |. . .| .||...   || |||.... |  . .     |.|....        |.| .|. ||.. |..  . . 
tvadfWamvldeqvstivmlnddnerdk.kcaryWsdkg..vttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsass

LIHFVKLVRASRAHDTT-PMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGS
|..... || .  . .  |..|||.||||||||....|    ...... |||.|||  || ||. .||   || |... .|. |. .  
llklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedt

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1982-2066 1.6e-10 35.0 In-house 5-86 (440) alignment
Range on Protein: 1982-2066
Range on HMM: 5-86/440.0
PISKKSFLQHVEElcTNNNLKFQEEFSELPKFLQDLsSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGY
||    | ..|..        |..|.| ||  |..  |  | || |. |||. ||  |...|| |    .|| |||||||||.| 
piivadfadyvqn..nrrsrafedewsllpsglsqp.sdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1983-2262 4.5e-92 303.5 In-house 2-282 (318) alignment
Range on Protein: 1983-2262
Range on HMM: 2-282/318.0
ISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGT
|| . . .||..| .. .|...||. .| .  .  .|...  | |.||||. || .|.. ||||   ....|||||||.|| ||   ...||.|.||| |
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

VGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKpvTVFGDIVITKLMEDVQIDWTIRDLKIERHG--DCMTVRQCNFTAWPEHGVPENSAPLIH
. ||||||||  ....|||||. |.|....|.|||...   . .|..|..   |    |...| .|..|..  .  .||| ..|.||..||||..| |..
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgs..rsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslld

FVKLVRASR-AHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSN
.|. |..    ....|..|||||||||||||||.| | ..|..   ||... | .||..|  |||   ||.|... .|. |  
lvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealas

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1983-2261 1.9e-81 268.6 In-house 5-284 (319) alignment
Range on Protein: 1983-2261
Range on HMM: 5-284/319.0
ISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDlSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGT
|  . . .....| .. . ....|| .| .  .| . . |. . |. |||..||..|.. ||.| .   |.||||||||.| ||   ..|||||.||  |
ievqeLkerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlent

VGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNkpVTVFGDIVITKLMEDVQIDWTIRDLKIERHGDCM---TVRQCNFTAWPEHGVPENSAPLI
. |||||||| .. ..||||.  ||.......|||| |  ....| ...| . |. . |. ||.||.... . .   .| .  .|.||.|.|||..  |.
iedfWrmvWeeessivvmltklveklkvklkkywpeen..feeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatsll

HFVKLVRASRAH-DTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLS
...| .| || . .  |..||||||||||| ||.||   ....    .|..  | .||  | .|||. .||.|... .|. ..
dllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1984-2259 7.8e-57 187.6 In-house 3-278 (439) alignment
Range on Protein: 1984-2259
Range on HMM: 3-278/439.0
SKKSFLQHVEELCTNNNLKFQEEFSELPKFLQD--LSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPG
... | .|||.|  |..  |.|.| ..     |    .. |   ....|||. .. ...  || |     || | |||| || ||  .. .||||||   
grdefqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkke

TVGDFWRMVWETRAKTLVMLTQCFEKGRirchqYWPEDNKpvTVFGDIVITKLMEDVQIDWTIRDLKIERHGD----CMTVRQCNFTAWPEHGVPENSAP
|. ||||.|.| .. |.||||. .|  .     ||| |..  ...|||..    .    ...|| .|.  . |      || |  ..|||.. || ... 
ttddfwrlviekktvtivmltnlvesyk.....ywpsdae..vcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqash

LIHFVKLVR-ASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDL
...|.. .  |   ... |..|||||||||||  ||||   ....  . ||| |.|  || .|  |||.|.||.|.....|. 
vldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavled

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1984-2263 9.9e-38 124.6 In-house 5-290 (305) alignment
Range on Protein: 1984-2263
Range on HMM: 5-290/305.0
SKKSFLQHVEELCTNNNLKFQEEFSELPKFlQDLSSTDA-DLPWNRAKNRFPNIKPYNNNRVKLiaDASVPgSDYINASYISGYLCPNEFIATQGPLPGT
 ||  |. |..   .    ...||. . .| .|.    |     .. |||. ..   .||||||  ... |  .|| | |.|    |. || || ||  |
qkkqilkfvkrtlekgpaglraefvamkrf.ndfekmkafkeaqeagknrykdvgcldnnrvkl..egpwp.heyihanyvstptnpkrfictqaplekt

VGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGD---IVIT--------KLMEDVQIDWTIRDLKIERHGD-CMTVRQCNFTAWPEHG
  ||| | .. . ... || .  |||  .|..|.. ..|.|  | .    ..         |. .| . . |   | ||  |     | .  .  ||. |
cadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrg

VPENSAPLIHFVKLVRASRahdtTPMIVHCSAGVGRTGVFIALDHLTQH-INDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNK
||     .. ...  |.|.     |..||||||.||||  . |... .  .. .   |   ..  .| .|   .|  |||.|.|| ||. . .|
vpaadlailellekarpsk....gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkk

0040438 (Phosphotyrosine protein) phosphatases II 1986-2266 4.3e-94 310.6 In-house 3-282 (317) alignment
Range on Protein: 1986-2266
Range on HMM: 3-282/317.0
KSFLQHVEELCTNNNLKFQEEFSELPKFLQDlSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGD
...|.... |. ... ...||| .|...  | . . | || |. |||.|.| || ..||||  . ....||||||||..|. ....|||||||||.||.|
ldlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntved

FWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEdnKPVTVFGDIVITKLMEDVQIDWTIRDLKIE--RHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVK
||||||| . ...||||...|.||. |.||||.  . ....||...| | |..  ..|.| |..|  ..... ||..  .|.||.||||..  .|..|..
FwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfle

LVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGSN
.||...... .|..|||||||||||.|||.. . .... . .||..  |.|||. |...||...||.||....|..| .|.  
avrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltl

subfamily_PTPRG_pd Subfamily PTPRG 1986-2265 7.8e-80 263.7 In-house 4-292 (563) alignment
Range on Protein: 1986-2265
Range on HMM: 4-292/563.0
KSFLQHVEELCTNNNLKFQEEFSELPK--FLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGS-DYINASYISGYLCPNEFIATQGPLPGT
| | .|| .| .... .|.||| .| .    .||  . .. | |. |||  || .|.. ||||   . . .. |||||.|| ||   ..||||||||. |
kefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdt

VGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNkpVTVFGDIVITKLMEDVQIDWTIRDLKIER-----HGD---CMTVRQCNFTAWPEHGVPEN
. |||||.|| .....||.|.  |.||  |..|||.|.  .  .| . .|   |.| .  |.| |.|.      . .     .||| ..| ||.||||| 
fddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkde..setygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPeh

SAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGS
|.| . |||   |.. ... |..|||||||||||..|.|| |.. |.... |...|..  .|..|  .||.  ||||||. .|.... |  
slpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasket

subfamily_PTPRK_pd Subfamily PTPRK 1986-2277 7.3e-75 246.7 In-house 7-296 (314) alignment
Range on Protein: 1986-2277
Range on HMM: 7-296/314.0
KSFLQHVEELCTNNNLKFQEEFSELPKFlqdLSSTDADLpwNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGD
.  ||..  | ....  |.||.  |..      ..  |   ||.|||. .| .|.. ||.||.    | ||||||..| .|  |..||.|||||. || |
adllqsiallkraegygfkeeyeslfeg...wdaakkde..nreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkd

FWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPvtvFGDIVITKLMEDVQIDWTIRDLKIER----HGDCMTVRQCNFTAWPEHGVPENSAPLIHF
|||.|.. .. ..||||.  |.||..| .||||| .    .||| .. .  ... .  .| ...|.    . .  .||| .|..||.|.|| .   |...
fWrlvydencasivmltelvevgrvkClkyWPedtev...ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllkl

VKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGSNQPICFVN--YSAL
|. | .|....  ...|||||| ||||.|||.| . . |. .. ||..  | .|||... ||.   ||.|... ||.      .  |.. ..  |   
vrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalyles

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1986-2261 4.6e-62 204.5 In-house 5-284 (290) alignment
Range on Protein: 1986-2261
Range on HMM: 5-284/290.0
KSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASV--PGSDYINASYISGYLCPNEFIATQGPLPGTV
. | ..|..  ...| .|...|  | .. .. . | .  . |. .||| || .|..||. |   ..      .||||.|| ||   ...||||||.. |.
dkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntl

GDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDnkPVTVFGDIVITKLMEDVQIDWTIRDLKIERHG---DCMTVRQCNFTAWPEHG-VPENSAPLI
 |||...|. .   .||||.  |.|. .|.||||.   ... .| . |. | | .  . ..| |... .    .. .| | ..|.|...| |..... |.
vdFWkliwqekvtiivmltniieegkvkCqqYWpds..dtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtill

HFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLS
 . . ..  | .  |...||||..|||..||.|..   .. .    .|.. .. ..|. .. .||   || ...| .|  |.
vieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1987-2282 5.3e-63 208.1 In-house 9-312 (325) alignment
Range on Protein: 1987-2282
Range on HMM: 9-312/325.0
SFLQHVEELCTNNNLKFQEEFSELPKfLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDF
 ...|||.  ....  |  ||  ||   .  . . | .| |.|||||.|. .....|| | .    | ||||||||.  .   . |.|.| ||. |..|.
nlvehvekkkaqdqdgfahefgllps.ddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindl

WRMVWETRaKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVIT-KLMEDVqIDWTIRDLKIE--RHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVK
||.| . |  ..|...  ...|  || .|||..      || . .  . .|..  |.  | |..   ..|. ..|.| .. .|.. ||..  | || ...
WrlvldWr.csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieei.sdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilq

LVRASR------AHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGSNQPICFV--NYS
|| |        .. .||..||||||||||||||.|  . ... ..  |||.| |  || .|  ||.   |||...... . . .  .. |.. .  . |
lvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeakls

ALQKMDS
.||. . 
slqernp

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1988-2265 5.7e-93 306.1 In-house 8-284 (288) alignment
Range on Protein: 1988-2265
Range on HMM: 8-284/288.0
FLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFW
 ...| .   .|.  |.||.  |... .. |.| . |. |  |||..|| ||. .||||     ..|.|||||||| |.   ...|||||||. ||.|||
pvakvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfW

RMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPvTVFGDIVITKLMEDVQIDWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRA
..|.|....|.||||.  |.|. .|..|||...|| . .|.. .| . .  . |.. | | .|.... ... | ...|||.|||||..|||..... |  
elvyenktstivmltelveggktkCeeYWPdadkp.knyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkv

SRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGS
.   || |.||||||||||||.||||| | .... .|..|. | ||.|| .|. .||.| ||.|.....|.| ...| 
anqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslieedgv

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1988-2261 1.1e-60 200.0 In-house 7-279 (287) alignment
Range on Protein: 1988-2261
Range on HMM: 7-279/287.0
FLQHVEELCTNNNLKFQEEFSELPKFLQDL-SSTDADLPWNRAKNRFPNIKPYNNNRVKLIadasVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDF
| . |..   ..|  |.. |  | .  |.  . | .  . |. |||. .| ...|.|| |         |||||..| ||   ..||....|.  |. .|
fgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnf

WRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKpvTVFGDIVITKLMEDVQIDWTIRDLKIERH---GDCMTVRQCNFTAWPEHG-VPENSAPLIHFV
|..... . ...|||.|  |. .  |.|||||..   .|.|.  |. | |.|. ....|.|.....   ||  .|.| ..|.|...| |.|  . |. . 
WkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvie

KLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLS
. ... | .  |...||||..|||...|.| .   .. .    .|.. .. . |  .. .||  .||.|. . .|  |.
emyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyld

subfamily_Ptp69D_pd Subfamily Ptp69D 1989-2262 1.4e-76 252.5 In-house 10-288 (307) alignment
Range on Protein: 1989-2262
Range on HMM: 10-288/307.0
LQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWR
 . ..    . .  ...|. .|..   |.|.. ..   |  |||...||.....||||        |||||||.| ||   ..||| |.|. .|.|||||
eealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWR

MVWETRAKTLVMLTQCFEKGRIRCHQYWPEDnkPVTVFGDIVITKLMEDVQIDWTIRDLKIERHGDCM-------TVRQCNFTAWPEHGVPENSAPLIHF
|..|   ...|||..  || | .|..|||..    . .|||...   |. . |..||.|.. . ...         | | ..|.|..  ||| .  |...
miaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllkl

VKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSN
.. ||    .. .|..|||||||||.|.|.||| | |...  | |||.  | .|||.|  .||.|.||.||.. .||  | 
ieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssy

subfamily_PTPRN_pd Subfamily PTPRN 1989-2257 2.4e-46 152.8 In-house 18-289 (297) alignment
Range on Protein: 1989-2257
Range on HMM: 18-289/297.0
LQHVEELCTnNNLKFQEEFSELPKFLQDLSST-DADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCP-NEFIATQGPLPGTVGDF
|...|.  . |. ....|.  | .. .. |..  |. . |  |||  .. ||...|||| ..||   ||||||| |         .|||||||. || ||
lsyledhlk.nkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadf

WRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDivITKLMEDVQI-DWTIRD--LKIERHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVK
|.||||  .  .|.||.  |.|  .|..|||.. . |  . .  .  . | .   |. .|   ||  .  .  || |  | .|||.||| .. .|..| .
wqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiye..vhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrr

LVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHIN-DHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCIL
 |  |    ..|..||||.|.|||||.|..| . ....     .||   .  || .|  .|.  .|. |  ... 
kvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltava

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1990-2262 2e-84 278.0 In-house 4-278 (281) alignment
Range on Protein: 1990-2262
Range on HMM: 4-278/281.0
QHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRM
.|...| .|.|  |.||...| .  .| ..| .  . |. |||. ||  |.. |||.  . .   .|||||....||  ..|.||||||.| .. .||.|
khlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqm

VWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKpVTVFGDIVITKLMEDVQIDWTIRDLKI-ERHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRAS
|||......||.|.  |.|...||.|||.||.  . .||...... |  .  .  | .|. ...|.  .|.| ..||||.||||.... |..| | |.  
vweqkvsaivmvtreieagklkChrYWPddns.elkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkl

RAHDT-TPMIVHCSAGVGRTGVFIALDHLTQHIN-DHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSN
. ..| .|...||||||||||..|||| | .... ..  .|.  .||||| ||. ||| ..|| |... .|| |..
tekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1993-2261 3.5e-73 241.5 In-house 19-291 (298) alignment
Range on Protein: 1993-2261
Range on HMM: 19-291/298.0
EELCTNNNLKFQEEFSELPKFLQ---DLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRM
.   ...  ....|| .| .  .   . ... |  | |. |||...| ...  || | .. .   |||||||....|   | |||||.||. || |||||
avkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrm

VWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKpvTVFGDIVITKLMEDVQIDWTIRDLKIERHG--DCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRA
|.|  ..|.||||.  |......|.|||...|  . .|.| .. | .... | ..| ||....   .  .||| .|| ||..|||||.  ...... |||
vteedigtiVmltnleeldktkyhkywPdegk..etygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra

SRAHDT-TPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLS
|. .   .|.||.|||||||.| |||.| . ....    ||..  |  || .|. .||  .||.|... .|. |.
sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1997-2261 7.5e-74 243.9 In-house 30-294 (319) alignment
Range on Protein: 1997-2261
Range on HMM: 30-294/319.0
TNNNLKFQEEFSELPKFLQDLS-STDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRA
 ..  |.. ||  ..|   .|.  | |.|. |. |||. || ....|.|||     . .|||||||...||  .. .||.||||. |. |||||.|| ..
dddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweync

KTLVMLTqcfekgRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQidWTIRDLKIERH---GDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVR--ASRA
 |.|.||      . .| |||| . .     ... .. . |  .  ...||... ..    |   ..|  |  ||..|||. ...|. .|| ||   |. 
stivllt......kdkcsqywplkivikeerfkvkvdsveetae..yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltske

HDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILD--LLS
.. ....||||||||||||.|.|| | . ... . ||.| .| .|| .|  .||.|.|| |..  .|.  |..
nhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfg

subfamily_PTPN6_pd Subfamily PTPN6 1997-2262 1.3e-71 236.1 In-house 22-299 (306) alignment
Range on Protein: 1997-2262
Range on HMM: 22-299/306.0
TNNNLKFQEEFSELPKF--LQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIaDASVPGSDYINASYISGYLC--PNEFIATQGPLPGTVGDFWRMVWE
. ..  |.||| || .    . || .... | |. |||. || |....||.|  . ||||||||||.||.. .    ...||||| |. || |||||||.
slekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwq

TRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTvFGDIVITKLMEDVQIDWTIRDLKIE---RHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASR
  .. .||.|.  |.|. .| .|||. ..  . .|.| .|.. |. . |...|.|...   ..... .|.| .|..||.||||..   ...|.. |.. .
ensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkq

AHD----TTPMIVHCSAGVGRTGVFIALDHLTQHINDHDF---VDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSN
 .     . |..||||||.|||| || .| |.. |. . .   .||. ||  .|. |  .||  .|| |... |   . .
eeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1997-2258 3.5e-51 168.8 In-house 5-264 (283) alignment
Range on Protein: 1997-2258
Range on HMM: 5-264/283.0
TNNNLKFQEEFSELPKFLQDLSSTDADlpWNRAKNRFPNIKPYNNNRVKLIADASvpgsDYINASYIS---GYLCPNEFIATQGPLPGTVGDFWRMVWET
.|||  |.| . .|    .|   . ||   |. |||. .| |....||.| ...     |||||..|     |   ...|..|.||  || |||.||.. 
vnnnklfrevlkrlsvpdldadiasad..enkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfde

RAKTLVMLTQCFEKGRIRCHQYWPEDNkpVTVFGDIVITKLMEDVQIDWTIRDLKIERH---GDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRA
.. ..||||.  |  ||.| ||||..      .|.  .|   |  .  ..|. | .       . . .    .  | | |       |..| |..   . 
kitaivmltklqedlrikCsqyWPkrG..sedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqte

HDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILD
.  .|..||||.|.|||.||||.    ...  .  ||..  |  .| .|| .||.| || ..|. .|.
skkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1997-2261 2.9e-48 159.1 In-house 13-294 (301) alignment
Range on Protein: 1997-2261
Range on HMM: 13-294/301.0
TNNNlkFQEEFSELPKFLQDLSSTDADlPWNRAKNRFPNIKPYNNNRVKLIADA--SVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETR
 .|.  |.|...|| .  .. ..   .   |.| ||| ||..|..||. |      ..   .|||||||.||   ..|||.|||.  |. ||||..|. .
hsnk..feeqykelkegedksctvgls.eenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqek

AKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLK-----------------IERHGDCMTVRQCNFTAWPEHGV-PENSA
  ..||.|.  |. . .|.||||. ..  . || . .|   | |  |..||.|.                 .... . ..| | . | ||..|| .|   
pvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprt

PLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLS
 |    . . . .  .  |..||||..|.|.||.....           ||.....  .|  .. .|. | ||..... |   |.
vLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq

0036941 (Phosphotyrosine protein) phosphatases II 1998-2265 8.3e-92 302.9 In-house 10-282 (297) alignment
Range on Protein: 1998-2265
Range on HMM: 10-282/297.0
NNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLiadaSVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKT
... ....||.||...| . | . | || |. |||...| ||...||||    . .|||||||||..|| ....|||||||||.||.|||||||| . ..
lflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtv

LVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDV--QIDWTIRDLKIER--HGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAH--
.||||...|.||. |.||||...  . ..||...| | ..|    |.|.| |...    |.  ||... .| ||.|||||. |.|..|..|||  ...  
Ivmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllp

DTTPMIVHCSAGVGRTGVFIALDHLTQHIN---DHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGS
. .|..|||||||||.|.|||.| . | ..    .  |||. .| .||. |...||.| ||.||....|.|| .|  
sggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt

0047943 (Phosphotyrosine protein) phosphatases II 1998-2259 6.9e-91 299.8 In-house 9-271 (273) alignment
Range on Protein: 1998-2259
Range on HMM: 9-271/273.0
NNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLiadaSVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKT
... ...||| .|...  .|. . | || |. |||...| ||...||||    . .|||||||||..|| ....|||||||||.||.|||||||| ....
lgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrv

LVMLTQCFEKGRIRCHQYWPEDNKP-VTVFGDIVITKLMEDVQIDWTIRDLKIER--HGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAH--D
.||||...|.||. |.||||...   ....|.. .| | |..  |.|.| |....   |.. ||..  .| ||.||||.. ..|..|..|||  ...  .
iVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealps

TTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDL
 .|..|||||||||||.|||||.| .... .  ||.. .|. ||| |..|||.. ||.||....|..
ngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley

subfamily_CG7180_pd Subfamily CG7180 1998-2258 2e-51 169.4 In-house 14-288 (296) alignment
Range on Protein: 1998-2258
Range on HMM: 14-288/296.0
NNNLKFQEEFSELPKFLQDLSSTDADLpWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKT
. ..... |.   |.. ..   ..  .  || ||| ... ||..||| |        ||||||.|. ..| ..|.| |..|   ||..|||.|..  ...
kfrveyklelkltprleigdCagglrk.enreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisa

LVMLTQCFEKGRiRCHQYWPEDNkpVTVFGDIVITKLMEDVQIDWTIRDLKIERH------------GDCMTVRQCNFTAWPE-HGVPENSAPLIHFVKL
.|.||. |.  .  ...|||..    . .|.|..  ..|.   . .|| .|. ..             .  .|.. ..| |.  . ||  .. ||.... 
vvvLtktfdfak.mypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrr

VRASRAHD-----TTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILD
||  | .      . |..|..| |..|.||..|.|   . .. .. ||... |  || .|  .|.|  .| .. . .|.
vrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlle

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1999-2270 1.3e-55 183.4 In-house 18-246 (392) alignment
Range on Protein: 1999-2270
Range on HMM: 18-246/392.0
NNLKFQEEFSELPKFlQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTL
 .  | ||| .||   .    | |  . |  |||. || ||...||||     .| |||.||||| .. . . .||.||| . .. ||||||.. .. |.
hsalffeefhdlpgp.diypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvtti

VMLTQCFEKGrirchqywpednkpvtvfgdivitklmedvqidwtirdlkieRHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIV
.|.|.  |                                            .  |. || |  || ||...||. .. |..|.| |.|   . | |.|.
amvtklkegd..........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythplii

HCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGSNQPIC
||||||||||| |..| .  | .   .||.. .|...| .|  |||   || |.. ..|. |  . .  |. 
hcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvv

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1999-2258 2.9e-39 129.7 In-house 4-257 (267) alignment
Range on Protein: 1999-2258
Range on HMM: 4-257/267.0
NNLKFQEEFSELPKFLQDLSSTDADLPW-NRAKNRFPNIKPYNNNRVKLIADAsvpgSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKT
.. ....|| .. |  .. |     ..  |...||. .  ||...|| |         .||||||. ||   | ||.||.||  |..||. .. . .  .
eeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtke....eeyinasyvegyktknafivtqdplkntitdfltvihdqkvpv

LVMLTQCFEkGRIRchQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKIERHGDC-MTVRQCNFTAWpehGVPENSAPLIH--FVKLVRASRAHDTT
 |.||. |. . ||  ..||        . |... . .|  . |. |  |... . ..   |    .  |    .  |  | ..  |  | .        
ivlltkvft.dnir..lfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkw...nintnnkpylkplfgilaknqlengnr

PMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILD
|..|.||.||||.| |. .|   . .   . .||. .. ..|| |. .|. . .||..|. . .
PlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae

0045098 (Phosphotyrosine protein) phosphatases II 2000-2262 2.8e-79 261.7 In-house 6-274 (278) alignment
Range on Protein: 2000-2262
Range on HMM: 6-274/278.0
NLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKliadasvpgsDYINASYISGYlcPNEFIATQGPLPGTVGDFWRMVWETRAKTLV
.|... || .|.   .  . |.| .. |..|||...| ||...|||          ||||||||.||  |..||||||||| || |||||.|| . ...|
sldlllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitviv

MLTQCFEKGRIRCHQYWPEdnKPVTVFGDIVITKLMEDVQIDWTIRDLKIE------RHGDCMTVRQCNFTAWPEHGVPENS--APLIHFVKLVRASRAH
|||...|.||. |.|||||  . . ..||...| | |.|  |.|.|.|...       .. ...|.. ... ||.||||...  ........ .|. ...
mltelvelgrekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkl

-------------DTTPMIVHCSAGVGRTGVFIALDHLTQHIndHDFVDIYGLVAELRSERMC-MVQNLAQYIFLHQCILDLLSN
             . .|..|||||||||||...|.. . ...  .. ||..  |.|||| |.. .|||| ||.||....|.||..
laslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 2001-2264 2.3e-75 248.3 In-house 19-281 (315) alignment
Range on Protein: 2001-2264
Range on HMM: 19-281/315.0
LKFQEEFSELPKFlQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVM
  | ||| .||   .    . |  . |  |||. || |....||||      | ||||||||| .. . . .||.||||. .| ||||||..... |.||
alfseefhdlpdP.diyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivm

LTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHC
.|.  |  .|.| ||||. .   . || | .. |  . . | ..| | . .  .  || | .|| ||..||..... |....| |.|.. ... ...|||
vtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhc

SAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKG
|||||||||.|..|.  ..|.. . ||.. .| .||..|. .||   .| |... .|. |  . 
saGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrn

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 2001-2258 3.4e-67 221.4 In-house 5-266 (274) alignment
Range on Protein: 2001-2258
Range on HMM: 5-266/274.0
LKFQEEFSELPKFLqdlSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASV-PGSDYINASYISGYLC-PNEFIATQGPLPGTVGDFWRMVWETRAKTL
 ....|| |||      .  . |.. .  |||. .| | .| || | .. |  . |.|||| || ||    . ..||||||| || |||||....... .
kdlekeflelPlnf...dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvi

VMLTQCFEKGRIRCHQYWPEDNKP--VTVFGDIVITKLMEDVQIDWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDT---
||||.  |. . .|..|.|....      .||. |.      . |...| | ..   .. .|    .|.||.| .|..  .|...|. |. || ...   
vmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenakl

TPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILD
.|..||||||.||||.||| .   ...... .||. ..|..|| .|  |||.  || ..|. .  
apvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl

0046845 (Phosphotyrosine protein) phosphatases II 2002-2263 1.1e-91 302.5 In-house 1-277 (284) alignment
Range on Protein: 2002-2263
Range on HMM: 1-277/284.0
KFQEEFSELPKFLQDL--SSTDADLPWNRAKNRFPNIKPYNNNRVKLIADAS-VPGSDYINASYISGY-----LCPNEFIATQGPLPGTVGDFWRMVWET
...||| ||...  .|  | . | || |. |||...| ||...||||    . ...||||||||..||      ....|||||||||.||.|||||||| 
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

RAKTLVMLTQCFEKGRIRCHQYWPEDnKPVTVFGDIVITKLMEDVQIDWTIRDLKIER---HGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRA
.....||||...|.||. |.||||.. . | ..||. .| | |.|. |.|.| |....    |  .||..  .|.||.||||.....|..|..||| .. 
nvrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrelle

--HDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHD---FVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNK
  ..  |..|||||||||||.|||||.| .... ..    ||....|. ||. |..|||.|.||.|.....|..|..|
nlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk

DSPc_SM00195 2002-2260 1.8e-86 285.1 In-house 1-262 (263) alignment
Range on Protein: 2002-2260
Range on HMM: 1-262/263.0
KFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVML
|..|||..| .  .. ..|.|. . |..|||. ||.||...||||  . . .|||||||.||.|. .....|||||||| || ||||||||.. |. |||
klkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

TQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQI-DWTIRDLKIERHG--DCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIV
|...|.|...|..||||...  ..||.| ..   .. .  ....|.|... .|  .  .|.| ....||.||||..  ....... |. |. . ..|..|
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLL
||||||||||.|...| . ....... |||  .| |||..|. |||.|.||.|....||...
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 2002-2260 1.8e-86 285.1 In-house 1-262 (263) alignment
Range on Protein: 2002-2260
Range on HMM: 1-262/263.0
KFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVML
|..|||..| .  .. ..|.|. . |..|||. ||.||...||||  . . .|||||||.||.|. .....|||||||| || ||||||||.. |. |||
klkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

TQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQI-DWTIRDLKIERHG--DCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIV
|...|.|...|..||||...  ..||.| ..   .. .  ....|.|... .|  .  .|.| ....||.||||..  ....... |. |. . ..|..|
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLL
||||||||||.|...| . ....... |||  .| |||..|. |||.|.||.|....||...
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 2002-2271 3.6e-75 248.0 In-house 19-287 (515) alignment
Range on Protein: 2002-2271
Range on HMM: 19-287/515.0
KFQEEFSELPKFlQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVML
 | ||| .||   .    | |.   |  |||. || ||...||||      | |||.||||| .. . . .||.|||.. .| ||||.|.. .  |..|.
lfseefhdlpgp.niypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamv

TQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHCS
|.  |  .|.| .|||.       || | .  .  .   . ..| |.. .  |. || | .|| ||..|||...  |. ..| |.|.. . | |.|.|||
tklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcs

AGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGSNQPICF
||||||||.|..|    |... . ||.. .|  .| .|. .||   || |... .|. |  . .  |.  
aGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvih

subfamily_PTPN14_pd Subfamily PTPN14 2002-2262 5.7e-59 194.6 In-house 24-298 (300) alignment
Range on Protein: 2002-2262
Range on HMM: 24-298/300.0
KFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVpGSDYINASYISGYLCPN--EFIATQGPLPGTVGDFWRMVWETRAKTLV
|   |. ..||  .|   . | || |  ||||... ||..|||.|..      ..||||| |.  .. .  ..|..||||. || |||.||||.  . .|
kvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqliv

MLTQCFEKGRIRCHQYWPED--NKPVTVFGDI-VITKLMEDVQIdWTIRDLKIE--RHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDT-
|||.  |.|. ....|.|..  .|    ||   |.||. || .   . . ||..    ..  ||    .| ||.|||||.  . ..... |.. | . . 
mlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsds.vittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktns

--------TPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSN
         |..|||||||||||| |  | |.. ..  . .||   .| ||  || .||.|||| |... ..  | |
eveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkn

subfamily_PTPN1_pd Subfamily PTPN1 2002-2258 2e-57 189.1 In-house 7-269 (290) alignment
Range on Protein: 2002-2258
Range on HMM: 7-269/290.0
KFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASvpgsDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVML
...| . .. |  .|.. ..|.|| ||..||. ...||.  |.||  .      |||||| .       ..| |||||| ||. ||.|||| ..|..|||
lykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvml

TQCFEKGRIRCHQYWPEDNK-PVTVFG--DIVITKLMEDVQIDWTIRDLKIER--HGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASR--AHDTT
 .. ||..|.|.||||....    ..    . .. . |...  .|.| |..|     .. .. .  .|.||. ||||  | ...|.  || |   ..|  
nkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvG

PMIVHCSAGVGRTGVFIALDHLTQHINDHDF---VDIYGLVAELRSERMCMVQNLAQYIFLHQCILD
| ..|||||.||.| |. .| .  .|...|    |||   . |||. |. ..|   |  | .. ||.
pavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 2002-2259 1.9e-47 156.7 In-house 17-276 (307) alignment
Range on Protein: 2002-2259
Range on HMM: 17-276/307.0
KFQEEFSELPKFLQDLSSTDAdLPWNRAKNRFPNIKPYNNNRVKLIADASvpGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVML
....||..| |   .  ...| .  |  |||. ..|  ...|. .  |     |||| | |.   . |. ||..||||  |. .|| |. . . ....||
alvdefrvlakktpegvtvea.fsantdknryqdvkcqdkgrivvkfdgl..asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesviml

TQCFEKGRIRCHQYWPEDNKPVTVFGDIVIT---------KLMEDVQIdWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSAPLIhfvKLVRASRaHD
 .. | ..|.|.|||| ..    |||.   |         ||  | ..   . .||..  ... |... ... ||..|||.     |    |. | |  |
ckvielakikceqywpleegqklvfgeapntisvanlgakklapdedl.invttlkvdwaqksrtiqhlqwenwpdrgvpqinltai...nlleavr.yd

TTPMIVHCSAGVGRTGVFIALDHLTQ-HINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDL
| |..|||||||||.|  .|.  . .  |.  .  |.  || ||||.|   .|. |||..||. .|. 
tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley

subfamily_ptpA1_pd Subfamily ptpA1 2002-2219 1.6e-42 140.7 In-house 22-255 (418) alignment
Range on Protein: 2002-2219
Range on HMM: 22-255/418.0
KFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYlCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVML
| .|||  | . .    ... |   | .|||. || | |  ||.|       ||||||| || |   |..||.|||||| |. |||||||| |.. .|||
kikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivml

TQCFEKGRIRCHQYWPEDNK--P-------VTVFGDI--VITKLMEDVQIDWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRAS--
..  |. ||.| .||||.              |||     . ....| . .   |....   |.   . | ..  ||.| .|. . |. .... .     
sresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqn

----RAHDTTPMIVHCSAGVGRTGVFIALDHLTQH
     .    |.|||||||||||| | .   . ..
qiipssdrnvpiivhcsagvgrtgtfctavimmkk

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 2002-2259 2.4e-39 129.7 In-house 12-268 (281) alignment
Range on Protein: 2002-2259
Range on HMM: 12-268/281.0
KFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIA-DASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVM
 |..|||.||        |  . | |  |||. ||   .  ||.|         .||| | ||   .    .| ||||   |  |||||.|.  . ..||
dfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivm

LTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSAPLIhfvKLVRASRAHDtTPMIVHC
| |  |  | .| .|.| . . .  |  . ..     |.       |..   |.   . .  .  ||.  ||| |  ..   |..|  ||.  || ..||
lcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevml...kilrkirars.tppvihc

SAGVGRTGVFIALDHLTQHINDH-DFVDIYGLVAELRS-ERMCMVQNLAQYIFLHQCILDL
||||||.| ..|..   | |  |  . ||  .|. ||   | . || | ||... . .||.
sagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 2002-2263 8.6e-22 71.9 In-house 27-288 (302) alignment
Range on Protein: 2002-2263
Range on HMM: 27-288/302.0
KFQEEFSELPKFLQDLSStDADLPWNRAKNRFPNIKPYNNNRVKLIADAsvpgSDYINASYISGYLCPNEFIATQGPLPGTV---GDFWRMVWETRAKTL
. ..|| .. ..  || .       | .||. .... ...|.||| | .     .|.||| ..   . .. | .| |  ...    .|||||.. . ...
evkkefkkidtmkvdlek.Ckafkknlkknqsedvpildsnlvkleaep....dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsv

VMLTQCFEKGRiRCHQYWPEDNKPVTVFGDIVITKL-MEDVQiDWTiRDLKIERH-GDCM---TVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDT
|.| .  |  .   ....|.     . .|.. . .   | .. . .   . ||    .|     .    .| |... ||.. | ||. .. | |. .. .
vilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekae.eek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikad

TPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNK
 ....    |.|| |.|..|    ....... . |  .|. .||.| ..|..| ||..|. ..| .. .|
entvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkk

subfamily_PTPN23_pd Subfamily PTPN23 2003-2258 5.3e-57 187.8 In-house 17-278 (288) alignment
Range on Protein: 2003-2258
Range on HMM: 17-278/288.0
FQEEFSELPKF----LQDLSSTDADLpwNRAKNRFPNIKPYNNNRVKLIadasVPGSDYINASYISGY--LCPNeFIATQGPLPGTVGDFWRMVWETRAK
....| || .      .. | . | |  .  |||. .| ||..|||||         ||||||.. .    ||. |||||.||..|..|||.||.| ...
ldkkfkeleqkqdkearkrsiaiakl..yseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPd.fiatqaPlqstlnDFWlmvyeqkss

TLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKIERHGD--CMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRA----SRA
..|||..  |.|. ....|||||.   ..|||. .|   .     .  |.||.| ..     .|.  ..|.|||.|||.    |..|.. |..     . 
viVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqr

HDTTPMIVHCSAGVGRTGVFIALDHLTQHINDH-DFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILD
.  ||..|||||||||||||  .    . .. .   .||  .|  || .|  |||. .|. |. . .| 
ksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 2003-2065 2.1e-07 24.8 In-house 15-76 (244) alignment
Range on Protein: 2003-2065
Range on HMM: 15-76/244.0
FQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLiADASVPGSDYINASYISG
 .|||  |  . ...  |.| |  | .|||. || |... || | . .   |||||||.|| |
akeefvglsdhtreflqtnavlsanatknryinilpfdetrvil.ssskkegsdyinanyiqg

subfamily_PTPN13_pd Subfamily PTPN13 2004-2261 7.2e-67 220.5 In-house 14-270 (273) alignment
Range on Protein: 2004-2261
Range on HMM: 14-270/273.0
QEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASvpgsdYINASYISGYLCPNEF--IATQGPLPGTVGDFWRMVWETRAKTLVML
.||| || ..   .... .    |..|||. |. ||.. |||| ....     |||||.|   .  .|.  ||.||||| || |||.|||| .|. ..|.
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv

TQCFEKGRIRCHQYWPED-NKPVTVFGDIVITKLMEDVQIDWTIRDLKIER--HGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAhDTTPMIV
|.  |||...||.||||  ||...| . . ...|    . ....|.|...    |.   | . ||..||.|||| ..|.|..||. ||  .  |..|..|
tlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivv

HCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLS
|||||.||.|..|..| . . |.    .|.  .| .||  |  .||   |||| .. ||..|.
hcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk

subfamily_CG42327_pd Subfamily CG42327 2004-2188 3.5e-27 89.9 In-house 8-193 (319) alignment
Range on Protein: 2004-2188
Range on HMM: 8-193/319.0
QEEFSELPkflQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYL-CPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLT
 ||| .||   | ....|.  .  . |.|. |. |  . || |   .. . . |..|||. ||  .|| .||.| .|  .  ||||.||| .....| ||
aeefrdlP...qliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqlt

QCFEKGRIRCHQYWPEDN--KPVTVFGDIVITKLMEDVQIDWTIRDLKIERH--GDCMTVRQCNFtAWPEHGVPENSAPLIHFVKLVRAS
. .|.|  .| .|.|  .  .   ..||| .|    .|.  . |  | . |     .  .    .  |.| .|| . |.||  .  ||.|
dlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss

subfamily_PTPN3_pd Subfamily PTPN3 2005-2260 1.2e-70 232.6 In-house 19-275 (280) alignment
Range on Protein: 2005-2260
Range on HMM: 19-275/280.0
EEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASvpgsDYINASYIS----GYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVM
 .| .| .  ..|. . | .| | .|||. .| ||.. |||| .  .    |||||.|..    .    | .|||||||. |. |||.|||| .....||
aqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivm

LTQCFEKGRIRCHQYWPEdNKPVTVFGDIVITKLMEDVQIDWTIRDLKIERHG--DCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIV
||.  |.||..||||||| ..  . .|.. ..   || .  . .|.| ....   .  .. |  ..|||.||||..|| ...||. ||. |. ...|..|
lttlverGrvkChqyWPe.tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvv

HCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLL
|||||.|||||.|.|.   . |. .. | .  .| ..|  |...||. .|| |. ..|| . 
hCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvy

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 2005-2264 9.5e-41 134.4 In-house 28-293 (305) alignment
Range on Protein: 2005-2264
Range on HMM: 28-293/305.0
EEFSELPKF-----LQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLiADASvpGSDYINASYISGYLCPN-EFIATQGPLPGTVGDFWRMVWETRAKTL
||| .| |.      | .  ..     . .|||. ..   ... ||| .. |   |||| | |.   . |.  ||..||||  |. .|| || . . . .
eefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkl.dkps..psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqi

VMLTQCFEKGRIRCHQYWPEDN-KPVTVFGDIV-----ITKLME-DVQIDWTIRDLKIErHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRah
||| .  | |...| ||||  . . ... . ||      .| || | .|. |. .|     .. |.||. ..| ||. |||      . ..  .| |.  
vmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltys.gdqkmsvrhlqwtewpdrgvppckltslellsairgsk..

dtTPMIVHCSAGVGRTGVFIALDHLTQHINDH-DFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKG
   |..||||||.||||  .|.... ..| .  .   .  ||  || .|   .||  ||.|.|. .|. . .| 
..vpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfleky

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 2008-2120 4.4e-07 23.0 In-house 6-88 (169) alignment
Range on Protein: 2008-2120
Range on HMM: 6-88/169.0
SELPKFLQDL--SSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINAsyisgylcpnefiatqgplpgtvgdfwRMVWETRAKTLVMLTQCF
 || .|.. .      |.|  | .|||       .. ||||       |||||||                           ||.||| |  .|.| .. 
nelkefmktieynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtd

EKgrircHQYWPEDN
.|      ..||| .
dk.....nnfwpeke

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 2009-2120 6.9e-07 22.2 In-house 6-87 (169) alignment
Range on Protein: 2009-2120
Range on HMM: 6-87/169.0
ELPKFLQD--LSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINAsyisgylcpnefiatqgplpgtvgdfwRMVWETRAKTLVMLTQCFE
|| .|..        |.|  | .|||       .. ||||       |||||||                           ||.||| |  .|.| .. .
elkefmktieynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtdd

KgrircHQYWPEDN
|      ..||| .
k.....nnfwpeke

0049772 (Phosphotyrosine protein) phosphatases II 2013-2274 6.8e-43 142.9 In-house 32-294 (314) alignment
Range on Protein: 2013-2274
Range on HMM: 32-294/314.0
FLQDLSSTDADLPWNRAKNRFPNIKPYNnNRVKLiADASVPGSDYINASYISGYlcpNEFIATQGPLPGTVGDF----------WRMV--WETRAKTLVM
 |..|. . |||. || |||...| |.. |||.|    .| |||||||||..|.   . ||||||||. || ||          ||||  .. .  ..||
vlpeltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivm

---------------------LTQCFEKGrirchqywpednkP--------VTVfgdivitklmedvqidwTIRDLKIERHGDCMTVRQCnftAWPEHGV
                     |... ..|             .                            .. . .    .  ... ..    .| ...
srdevladelsrLdaAlgKtpllildgng.............neptaadlellk.................eelydpelferlgikylri...pvpDgsa

PeNSAPLIHFVKLVRASraHDTTPMIVHCSAGVGRTGVFIALDHLTQHINdHDFVDIYGLVAELRS--ERMCMVQNLAQYIFLHQCILDLLSNKGSNQPI
|  .. . .|......   .. .| .|||.||.||||.|.... |  . .  .. ...  | . |.   .. ....| ||.| ....|..|... ..  .
p.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllg.vsleealedvrlkRpinpnpgfieqleqyefilealleylkflkkfyey

CFVNY
.  |.
leenl

subfamily_PTPN12_pd Subfamily PTPN12 2015-2262 1.2e-79 262.2 In-house 28-279 (290) alignment
Range on Protein: 2015-2262
Range on HMM: 28-279/290.0
QDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQ
.  |.. .. . |..|||. .| ||...||.|  . ...|||||||..| |   . |.||.||||| |. |||||.||.. . .||. . .| |...|..
kvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCer

YWPEDNKPVTVFGDIVITKLMEDVQI-DWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIAL
|||| ..  . ||.. .|.  |.    |..|| ||.|..... .|.| ..||||.||||..  .|.....|||  . .. .|..|||||||||||. ||.
YWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiai

DHLTQHINDHDF---VDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSN
|.  . ....     .|.. ||.||| .| ..||   || ........|...
dyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 2016-2257 8.1e-33 108.3 In-house 41-287 (310) alignment
Range on Protein: 2016-2257
Range on HMM: 41-287/310.0
DLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPgSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQY
| | |      .  |||. ..   .. ||||  | |    ||| | |.      . || .||||  |. |||||... ||.....| .  |.|| .|  |
dssltyeaykkymhknrysdvvcldtsrvklkidksry.edyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgy

WPEDNKpVTVFGDIVITKLMEDVQiDWTIRDLKIERHGDCMT------------VRQCNFTAWPEHGVPENSAPLIHFvKLVRASRaHdtTPMIVHCSAG
||        .| | .|.| |  . .. | .| .    | .             |   ..  ||. |||..    .   .|.   | |   | .||||||
wpslgv.tetygcirvtnlsesse.efeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpq.rllaqvr.h..gpcvvhcsag

VGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCIL
..|..| .||.   ....  . ||.  ...||. .|.  .|.  ||.....  .
kdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 2018-2261 5.3e-72 237.7 In-house 16-258 (284) alignment
Range on Protein: 2018-2261
Range on HMM: 16-258/284.0
SSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTqcfekgRIRCHQYWP
  | |.|. |. |||. .| ....|.|||     . .|||||||.|.||  .. .|||||||. |. |||||.|| .. |.|.||      . .| ||||
dqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywp

EDNKPVTVFGDIVITKLMEDVQidWTIRDLKIERH---GDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVR--ASRAHDTTPMIVHCSAGVGRTGVFIA
 . .     ... .. . |  .  ...||... ..    |  ..||  |  ||..|||. ...|. .|| ||   |. .. ....||||||||||||.|.
lkivikeerfkvkvdsveesee..yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyiv

LDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILD--LLS
|| | . ... . ||.| .| .|| .|  .||.|.|| |..  .|.  |..
ldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfg

subfamily_PTPN9_pd Subfamily PTPN9 2019-2259 2.9e-66 218.5 In-house 34-289 (297) alignment
Range on Protein: 2019-2259
Range on HMM: 34-289/297.0
STDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPE
 . . |. |  |||. ..  |.. ||.|      . ||||||... ||  .. ||||||||. || |||||||| .. ..|| |.. |.||..| ||||.
flasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpl

DNKPVTVFGDIVITKLMEDVQIDWTIRDLKIE--RHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAH-------------DTTPMIVHCSAG
... .. |||. ....  ... |...| |.|.  ....  .|    |..||..|||...| |..... ||  .|              .  |..||||||
eeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaG

VGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDL
.|||| ||.||   ..... . ||.   |  ||. |  ..|   || | ....|. 
iGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley

0037934 (Phosphotyrosine protein) phosphatases II 2021-2259 4e-72 238.0 In-house 4-241 (243) alignment
Range on Protein: 2021-2259
Range on HMM: 4-241/243.0
DADLPWNRAKNRFPNIKPYNNNRVKLiadasvPGSDYINASYISGYlcPNeFIATQGPLPGTVGD----FWRMVWETRAKTLVMLTQCFEKGRIRCHQYW
 | ||.|. |||...| ||...||||      .|||||||..| ..  |. .||||||||.|| |    ||||.|| . ...||||...|.||. |.|||
iallpenlsknrysdilpydhsrvkl......egsdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PedNKPvtVFGDIVITKLMEDVQIDWTIRDLKIER---HGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRAS--------RAHDTTPMIVHCSAGVG
|  ..   ..||...| | | .  |.|.| |..|.    . . .|..  ...||.||||.. ..|. |.. ||.          ...  |..||||||||
p..gev..tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RTGVFIALDHLTQHIndhDfVDIYGLVAELRSERMC-MVQNLAQYIFLHQCILDL
|||..||.. . ...   . ||..  |..||. |.. .||.. ||.||....| |
RtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 2021-2262 2.7e-17 57.3 In-house 41-281 (303) alignment
Range on Protein: 2021-2262
Range on HMM: 41-281/303.0
DADLPWNRAKNRFPNIKPYNNNRVKLiADasvpgSDYINASYISgYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEdN
  ..  |  |||| ..   .  .||| .|     | || |||.    . .  | || ||. |  |||.|. | . | ...|    |  ..  .  .|. |
knqfvknmdknrfvdvicldhskvkl.sd.....ssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfpr.n

KPVTVFGDIVIT-KLMEDVQI--DWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSAP-LIHFVKLVRA--SRAHDTTPMIVHCSAGVGRTGVFIALD
.    | . .|    .  |..   |... | .        .    . |||   .| ...| ... .  ...   .  |.|| .    .|.||.| |  ..
qdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfe

--HLTQHiNDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSN
  ||. | ..   .|.   .  .|  |.  ||||.|. ...  . . . .
tahlslh.seqasldlvkclenvrngrlhavqnlsqfsvvytllaehvld

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 2021-2151 1.2e-12 42.0 In-house 90-213 (244) alignment
Range on Protein: 2021-2151
Range on HMM: 90-213/244.0
DADLPWNRAKNRFPNIKPYNNNRVKLIAdASVpGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKgrircHQYWPeDN
||  | |  |||     |.. ||| |   .|. |  |||||..       |.| || ||  |  |||.|. |   . ||.|    |.      .||| | 
dafnpnnswknregaglpfdfnrvplsk.gsm.gntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywp.ds

KPVTVF-GDIVITKLMEDVQIDWTIRDLKIER
.|.  .  || .|    |   .    .|.|| 
eplewyeeditvtltdrdefknikasnleies

0040439 (Phosphotyrosine protein) phosphatases II 2023-2261 4.8e-80 264.0 In-house 7-247 (249) alignment
Range on Protein: 2023-2261
Range on HMM: 7-247/249.0
DLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEdnKP
 ||.|. |||.|.| ||...||||    ....|||||||||.|| ....|||||||||.||.|||||.|| . ...||||...|.||. |.||||.  . 
llpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..gg

VTVFGDIVITKLMEDVQIDWTIRDLKIE--RHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAH--DTTPMIVHCSAGVGRTGVFIALDHLTQ
....||...| | ..|  |.|.| |...   .|.  ||.. ..| ||.||||.. ..|. |...||  ...  . .|..|||||||||||.|||.. . .
sleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmle

HINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLS
... .  ||..  |..||| |...|||. ||.||....|.|| 
qlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll

0042113 (Phosphotyrosine protein) phosphatases II 2024-2261 4.8e-78 257.2 In-house 6-244 (245) alignment
Range on Protein: 2024-2261
Range on HMM: 6-244/245.0
LPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEdnKPV
||.|. |||...| ||...||||  | . ..||||||||..|| ... |||||||||.||.|||||.|| . .|.||||...|.||. |.||||.  . .
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..ges

TVFGDIVITKLMEDVQIDWTIRDLKIE--RHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRA-HDTTPMIVHCSAGVGRTGVFIALDHLTQHI
...||...| | |..  |.|.| |...  ...   .|..  .. ||.||||.... |. |...||  .| .. .|..|||||||||||.|||.. . ...
ltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleql

NDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLS
. .  |...  |.|||| |...||.. ||.||....|.||.
ekelgvsleeavkelrsqRpgavqtpsqyrflyeallellk

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2024-2261 8.6e-67 220.3 In-house 46-280 (315) alignment
Range on Protein: 2024-2261
Range on HMM: 46-280/315.0
LPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDnkpV
   |. |||. || .|.. ||.|      |.|||.||..| ||  .. .||.|||.. .|.||||.|.|    ..||||.  |. . .. .|||..    
kienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...k

TVFGDIVITKLMEDVQIDWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDH
 ..| | .|.  |.|. ..|.| | .    .  .| | ..|.||. |||. . ||..... |.  .  . ....||||||||||| ||.|| . ....  
viyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeae

DFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLS
. .|.| ..  .|. |. ||| ..|| |... .|. . 
naidvynfitgvrqnrikmvqvaeqyqfiydalletfv

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 2025-2261 1.1e-69 229.5 In-house 7-243 (250) alignment
Range on Protein: 2025-2261
Range on HMM: 7-243/250.0
PWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIrCHQYWPEDNKpvT
| |. |||. .| .... || |  . .   |||||||.. ||   . ||||||||. |. ||||||.|  ..|.||||.  |...  .||||| ..   .
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka..e

VFGDIVITKLMEDVQIDWTIRDLKIERHGDCMT--VRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAH-DTTPMIVHCSAGVGRTGVFIALDHLTQHIN
 .||. .. | ...  |.|.| ||. ..       ||| .|..||. ||||.    ....| |.||. . ...|.||.|||||||.| |||.| . ....
kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlk

DHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLS
    ||.. ..  || .|. .|. |.||.|... ||  | 
kekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 2025-2258 1.4e-61 202.8 In-house 18-262 (270) alignment
Range on Protein: 2025-2258
Range on HMM: 18-262/270.0
PWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLC-PNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKP-
  ... ||. .| |  . ||.|    . . . |||| |. |.   ....||..|||| |. .||||.||......||.|.  |||| .| .|||...|  
argkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkek

-VTVFGDIVITKLMEDVQIDWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSA------PLIHFVKLVRASRAHD--TTPMIVHCSAGVGRTGVFIAL
  . .|.| ...| |  .  . .. |..|..|.   .    ...||.||||...        |.. .. ||.|. .   ..|..|||||||||||..|||
vkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlial

DHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILD
|. .. .. .  ||.  ...||| .|| .||   || ||.. .. 
DiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 2026-2257 3.7e-56 185.0 In-house 37-274 (287) alignment
Range on Protein: 2026-2257
Range on HMM: 37-274/287.0
WNRAKNRFPNIKPYNNNRVKLIADASvPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTV
 .  |||. .. |....|| | |..   ||||||| |...|   ..|||.|||.. ||.||||.|.|||. .....|.  |..| .|..|||| ..|. |
aavkknryadvlPiddtrvllsaege.lGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrv

FGDIVITKLMEDVQIDWTIRDLKIER-HGD-CMTVRQCNFTAWPEHGVPENSAPLIHFVKLV----RA-SRAHDTTPMIVHCSAGVGRTGVFIALDHLTQ
 |  |.    .  . ....| |..   ..  .  |.| .. .||.....  .  || ||  |     .   | .. |..||...|.||.|...|.  | .
GGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvs

HINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCIL
  .|   ||.   |. ||  | ..||   |. .| . . 
rledlGrvdvaavvirlreyraalvqavvqlrllyealv

subfamily_egg_pd Subfamily egg 2026-2259 3.5e-27 89.9 In-house 39-269 (307) alignment
Range on Protein: 2026-2259
Range on HMM: 39-269/307.0
WNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKgrIRCHQYWPEDNKPVTV
 |. | | . ..  .  ||||         |.| | ...|    |||| .| ||  || ||||||.. . . .||||   |    ||. |||  ..   |
nnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslv

--FGDIVITKLMEDVQID--WTIRDLKIerHGDCmtvRQCNFT-AWpeHGVPENSAPLIHFVKLVRASRAHdTTPMIVHCSAGVGRTGVFIALDHLTQHI
   | . |. |  | . |  ...  ||.   |     ..  |   |   |  .||. .   ....|  |   ..|..|..  || ......|..    ..
tvpGslrienlkvdskadplfrvtklkl..vGgd...deerflehw..qgdvnnssdvysplrvlrklrnl.skpvvvqdilGvskaatlvaieiallsl

NDHD--FVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDL
         .   |  || .|   |.   .|.|... .| .
lrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlff

Y_phosphatase Protein-tyrosine phosphatase 2027-2257 6.8e-78 256.7 Pfam-A 1-234 (235) alignment
Range on Protein: 2027-2257
Range on HMM: 1-234/235.0
NRAKNRFPNIKPYNNNRVKLiadASVPG-SDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTV
|. |||...| ||...||||    . .| ||||||.|..||  ...||||||||. |..|||||||. . |..||||.. ||||  |.|||||...  . 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGDIVITKL--MEDVQIDWTIRDLKIERHGDCM---TVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHI
.||| ..     .. . ..|.|.|... ...     .|.|  .|.||.|||||.. .|..... |. |......|..|||||||||||.|.||| | ...
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

NDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCIL
.... ||.. .| |||..|. |||.|.|||||...||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 2027-2257 6.8e-78 256.7 In-house 1-234 (235) alignment
Range on Protein: 2027-2257
Range on HMM: 1-234/235.0
NRAKNRFPNIKPYNNNRVKLiadASVPG-SDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTV
|. |||...| ||...||||    . .| ||||||.|..||  ...||||||||. |..|||||||. . |..||||.. ||||  |.|||||...  . 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGDIVITKL--MEDVQIDWTIRDLKIERHGDCM---TVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHI
.||| ..     .. . ..|.|.|... ...     .|.|  .|.||.|||||.. .|..... |. |......|..|||||||||||.|.||| | ...
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

NDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCIL
.... ||.. .| |||..|. |||.|.|||||...||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 2027-2258 2.9e-59 195.2 In-house 3-237 (237) alignment
Range on Protein: 2027-2258
Range on HMM: 3-237/237.0
NRAKNRFPNIKPYNNNRVKLIADASVpgSDYINASYISGYL-CPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTv
|..|||. ||. |. .|| |    |   ||||||.|. |.   |...||.||||  .  |||.|||. .   .||||   |. ...||.|||. ..| . 
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa.

FGDIVITKLMEDVQIDWTIRDLKIERHGDCMTVR---QCNFTAWPEHGVPENSAPLIHFVKLVRASRAH--DTTPMIVHCSAGVGRTGVFIALDHLTQHI
.| . ..   ..   |.|.| | . ...    ||   | .||.||..|||...| |. | | .     |  ...| |.||||||||||.|. .| . .. 
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

NDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILD
...  ||||  |  .  .|  ..|   ||.|.|| ||.
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtile

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 2027-2258 4.2e-50 165.1 In-house 7-238 (239) alignment
Range on Protein: 2027-2258
Range on HMM: 7-238/239.0
NRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYL-CPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNkpvTV
|.||||. ||  |. .|| |   .  | ||||||||.  |   |. .||||| .  . ||||||.|. |   .||||   |  . .||||||.     . 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst...sk

FGDIVITKLMEDVQIDWTIRDLKIERHGDC--MTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDH
. .. .|    .|  |. || . . . |.     | |  || ||..|||. .. .. . . .       . | ..|||||||||| |. .| . .. . .
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

DFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILD
  |||.  |  .| .|  |||   ||.|.| ..|.
ktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 2027-2257 5e-50 164.9 In-house 8-238 (239) alignment
Range on Protein: 2027-2257
Range on HMM: 8-238/239.0
NRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYL-CPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNkpvTV
|.||||. ||  |. .|| |   .  | ||||||||.  |   |. .||||| .  . ||||||.|. |   .||||   |  . .||||||.     . 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst...sk

FGDIVITKLMEDVQIDWTIRDLKIERHGDC--MTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDH
. .. .|    .|  |. || . . . |.     | |  || ||..|||. .. .. . . .       . | ..|||||||||| |. .| . .. . .
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

DFVDIYGLVAELRSERMCMVQNLAQYIFLHQCIL
  |||.  |  .| .|  |||   ||.|.| ..|
ktvdifnyvkairedrphmvqtseqyvfihlavl

0041856 (Phosphotyrosine protein) phosphatases II 2027-2263 3.6e-47 155.6 In-house 1-174 (182) alignment
Range on Protein: 2027-2263
Range on HMM: 1-174/182.0
NRAKNRFPNIKPYNNNRvkliadasvpGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTqcfekgrirCHQYWPEDNkpvtvf
|. |||...| ||...|          ..|||||... |.| ...||||||||..|| ||.||..| . .|.|.||         ...||||.       
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

gdivitklmedvqidwtirdlkierhgdCMTVRQCNFTAWPEHGVPEnSAPLIHFVKLVRAsrahDTTPMIVHCSAGVGRTGVFIALDHLTQHindhdFV
                              .. |  .. || ||||.    |..|.. |..    .  | .|||||||||||...|.. . ..      |
............................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gv

DIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNK
...  |...|| |..||... ||.||....|.|| .|
sleeavklvrsrRpgmvitpnqyfflqlallellllk

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 2027-2263 1.2e-39 131.1 In-house 43-274 (288) alignment
Range on Protein: 2027-2263
Range on HMM: 43-274/288.0
NRAKNRFPNIKPYNNNRVKLIADASVpgsdYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVF
| ...|. |.   .  ||||  |.      ||.|  .|    .. .| .| || ||.. .|.|. |.  . .|||..  |||. .  .|.|      . .
nptrdryenlprcditrvklsddpdf....yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

GDIVITKLMEDVQIDWT--IRDLKIERHGDCMT-VRQCNFTAWPEHGVPENSAPLIHFVKLVrasRAHdTTPMIVHCSAGVGRTGVFIALDHLTQHINDH
| .      . ..|| .  .  |.|...|.    |..  .  |...|||||  . ..... .   ... . |..||.|||||||| .|      . .  .
grlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl...ksl.qkPivvhssaGvGrtgtlililialeslrld

DFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNK
||. |  |.|.|| ||.  .|   ||...|.|.|. |  |
dflgirsllaklreerfkaiqtemqylyvhrcvleelllk

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 2027-2263 3.4e-33 109.8 In-house 35-273 (285) alignment
Range on Protein: 2027-2263
Range on HMM: 35-273/285.0
NRAKNRFPNIKPYNNNRVKLIADAsvpgSDYINASYISGY-LCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTV
|   ||. ...  .. || |         ||| ||..       . .|.|||||| |. |||.|... .   ..||   || |  .|  |.||    |  
npdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvk

FGD--IVITKLMEDVQIDWTIRDLKIERHGD----CMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDtTPMIVHCSAGVGRTGVFIALDHLTQH
||   | .|.  |.      .  | .    |     . . . .   ||..  ||.. |.| . | |.    .. .|. ||||||||||  |. .|. | .
fgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpke.kpicvhcsagvgrtatfvgidyatir

INDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNK
| .   ...  .| |.|. |.  ||.  |..||.  ... .  .
imenpniemldivremramrfqavqshmqflflyvvlmeyfige

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 2027-2101 1.9e-09 31.5 In-house 37-116 (347) alignment
Range on Protein: 2027-2101
Range on HMM: 37-116/347.0
NRAKNRFPNIKPYNNNRVKLIADASV-----PGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVML
. .|||  . |  .. || |  . |      .   |||||.|    . .|.| || ||| || |||.||  |.   .| .
slsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 2028-2260 3.3e-41 135.9 In-house 57-283 (290) alignment
Range on Protein: 2028-2260
Range on HMM: 57-283/290.0
RAKNRFPNIKPYNNNRVklIADASVPGsDYINASYISGYLCPneFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFG
  |||. ..   .  ||  | .   .| ||. | |. |   .  || |||.|  || |.|||| .... ..||| . .|.|. .|.||.|| .  |  ||
fkknrykdvvcndktrv..ilkdGydG.dyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfG

DIVITKLMEDVQIDWTI-RDLKI--ERHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASrahdTTPMIVHCSAGVGRTGVFIALDHLTQHINDHD
.| ..  .|| . . .| . | .     |    ..  .  .||.. |.  .  |.  .. .|      . |..||||||.|||| |.|..   | . |  
eitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka....sGpvvvhcsaGiGrtGtfvaievglqilldGk

FVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLL
 .|. .||  ||  |.  ||   ||. | . .||| 
eldlldlvralrnsrlnsvqvdiqylalveilldlG

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 2028-2252 3.5e-31 103.1 In-house 51-273 (301) alignment
Range on Protein: 2028-2252
Range on HMM: 51-273/301.0
RAKNRFPNIKPYNNNRVKLIADAS-VPgsdyINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVF
. |.|.|..    .  |..|.|   ||    | | .|.    |. ||||||||. |  ||| |.     ...|||.|  ||   .|..| | . .     
kdkhryptvPckPstavevivdGkrvP....ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldi

GDIVITKLMEDVQI--DWTIRDLKIERHG---DCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRahdtTPMIVHCSAGVGRTGVFIALDHLTQHIN
|   |.   ... .  . . | |..|      .  ||   ... |...|||.  | | ....||. |.     |..||||||.||.  ||. . |.....
grfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkkse....kPivvhcsaGiGrsvafigteylareve

DHDFVDIYGLVAELRSERMCMVQNLAQYIFL
 .  ...   ...|| .| . ||.  |  ..
adptieltealkhlrehrwngvqtnsqlywm

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 2028-2120 6.4e-22 72.7 In-house 48-154 (350) alignment
Range on Protein: 2028-2120
Range on HMM: 48-154/350.0
RAKNRFPNIKPYNNNRVKLI--------ADASVPGSDYINASYISGY----LCPNEF--IATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCH
 ||||. || ||. .||||          . |. ..|||||.|..          .|  ||||.||| || ||.... .   | ...||. .| .. .|.
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

QYWPEDN
.||.| .
rYWqegs

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 2029-2181 2.3e-31 103.8 In-house 35-189 (297) alignment
Range on Protein: 2029-2181
Range on HMM: 35-189/297.0
AKNRFPNIKPYNNNRVKLIAdaSVPGSDYINASYISGY--LCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVF
 |||. .|  ....||||    .....||||| |.       .  .| .||||  || |||..|.|   ...||...  | || .|  |||. ..     
rknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlka

GDIVITKLMED--VQIDWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSAPLIHF
||.|.  | .         . .|..    .   || ..| .||.|||| .   |  |
gdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrf

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 2029-2265 2.3e-26 87.3 In-house 45-281 (312) alignment
Range on Protein: 2029-2265
Range on HMM: 45-281/312.0
AKNRFPNIKPYNNNRVKLIADASVpgsdYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGD
  ||.|||. ..  |  |  |       || | ..     |. |..|||||  |.  ||...    . ....|.   | |  .| .|  .    | .   
dlnrypniqcwdrgrftlagdenf....yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledh

IVITKLMEDVQIDW------TIRDLKI--ERHGDCMTVRQCNFTAWPEHGVPENSAPLIhfvKLVRASRaHDTTPMIVHCSAGVGRTGVFIALDHLTQHI
 | |.   ...|        | | ||.     |.   . . ....||.||.|.         .|. | . .|  |.| |||||||||| .. .. .   .
rvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtal...rllsavk.kdkkpviahcsagvgrtgtlaliesmiaal

NDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGS
      ..      || .|   |. ..||..  .|.|..| .|| 
rhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgl

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 2029-2120 1e-11 38.8 In-house 50-157 (349) alignment
Range on Protein: 2029-2120
Range on HMM: 50-157/349.0
AKNRFPNIKPYNNNRVKLIAD--------ASV------PGSDYINASYISGY--LCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRC
||||. .| ||.  ||||           ||          ||||| |..       . .|||| ||| || ||....   . | .. |.. .|..  .|
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

HQYWPEDN
..|| | .
diywqels

subfamily_eak_pd Subfamily eak 2033-2263 1.2e-13 45.2 In-house 57-308 (332) alignment
Range on Protein: 2033-2263
Range on HMM: 57-308/332.0
FPNIKPYNNNRVKLIADASVPgSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVIT
  .| ||. . |.| .    .   ||||| .      ...| |  .    |  ||.|| | .. ..|.| .  |..  .  .|.|.. . .  || . ..
vvkivpydrylvrltssqlnr.lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildve

KLMEDVQIDWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSA-------------PLIHFVK--LVRA--SRAHDTTP---MIVHCSAGVGRTGVFIA
.     .     | |....  .   |   ..  | |  .|                 .|.  .|  |...   . . | |    |. .. |  |.|||. 
rkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapiiqsarGsaraGvfvv

LDHLTQHINDH--DFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNK
.| | . |...  .   .  |.   .| |.  |    |. |... .|| | ..
idllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrr

0044763 (Phosphotyrosine protein) phosphatases II 2038-2262 7.9e-33 108.9 In-house 1-173 (178) alignment
Range on Protein: 2038-2262
Range on HMM: 1-173/178.0
PYNNNRVKLIADASVPGSDYINASYISGYlcpnEFIATQGPlpgtvGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKpvtvfgdivitklmed
|. ..||.|.    ...|||||||.| ..     ......|      |......|   ...|.||. .| |.. |..||||..                 
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

vqidwtirdlkierhgdcmtvRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHindhdFVDIYGLVAELRS
                      |  .. .| ||||. .. .  ||..... .. .  | .|||||||||.|...|.. . ..      ....  ....|.
.....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvre

ERMcMVQNLAQYIFLHQCILDLLSN
 |. .|.|  |. .|... | ||..
rRp.ivpnpgqlrqLyefelrllke

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 2040-2259 2.7e-18 61.1 In-house 31-258 (290) alignment
Range on Protein: 2040-2259
Range on HMM: 31-258/290.0
NNNRVKLIADASVPGSDYINASYISgylCPN--EFIATQGPLPG-------TVGDFWRMVWETRAKTLVMLTQCFEKGRI----RCHQYWPEDNKPVTVF
...|| |    .   .||| |....   |||  ..|.|| |.         |. .|| |. . ..| .||| .  || .      | .| ||       |
eatrvvLkgygkrfnddyiHAnrvt...cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkf

GDIVITKLMEDVQIDWTIRDLKIERH-GDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASrahdTTPMIVHCSAGVGRTGVFIALDHLTQHIN-DHD
... .       . |  .| | ..   .  .||    .  | .  |.|..  |.. .. |.||    .||.||||  |. |  .. |..   | |   ..
kgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkas....ktpvivHcvdGiSrsAalaaiilgyQkiaetsg

FVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDL
 | .  .. .||..|  ....  .. |    |. |
svkledvlkalrkqralaitsalelafvdagivll

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 2042-2155 1.3e-08 29.2 In-house 8-106 (130) alignment
Range on Protein: 2042-2155
Range on HMM: 8-106/130.0
NRVKliadasvpGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKgrircHQYWPeDNKPVTVFGDIVITKLMEDVQID
.|..        | .|||||..      .|.. || ||  |  |||.|. |     ||.|    |.      .||| | .|.  . . .|  | .  . .
srlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywp.dsePlewyeediivtltdrdefk

wTIRDLKIERHGDC
  |.  ..| . | 
.nikasnleiesdl

0051429 (Phosphotyrosine protein) phosphatases II 2052-2261 8.4e-54 178.3 In-house 1-226 (272) alignment
Range on Protein: 2052-2261
Range on HMM: 1-226/272.0
VPGSDYINASYISGYLC---PNEFIATQGPLPGTVGDFWRMvWETRAKTLVMLTQCFEKGRIRCHQYWP----------EDNKPVTVFGDIVITKLMEDV
.| |.||||....||     |. .....|||| |. ||||. .| . || |.|....|.||  |..|||          .|  |   .|....| |.| .
lplsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

QIDWTIRDLKIE---RHGDCMTVRQCNFTAWPEHGVPENSapLIHFVKLVRAsrahdTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVD--------
. |...| | ..     |. ..|..  .|.|| ||||...  |.....|...       |..||||||..|||...||..| . ..... ||        
lldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

IYGLVAELRSERMCMVQNLAQYIFLHQCILDLLS
... |.|||. |...||. .||.||....|.|| 
leeaveelraqrpgavqteeqylflyeallellr

0046846 (Phosphotyrosine protein) phosphatases II 2052-2261 4.7e-41 135.8 In-house 9-174 (176) alignment
Range on Protein: 2052-2261
Range on HMM: 9-174/176.0
VPGSDYINASYISGYLcpneFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTvfgdivitklmedvqidwtirdlkier
 ...|||||..| |..    .||||||||.|. ||..|..| . ...|.||...|.||..|..||||  |.                             
dldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...........................

hgdcmtvrQCNFTAWPEHGVPENsAPLIHFVKLVRASRAHDtTPMIVHCSAGVGRTGVFIALDHLTQhindHDFVDIYGLVAELRSERM-CMVQNLAQYI
        |  .. ||.||||.  . |.......|  . ..  | .||||||.||||...|.. |      . .....  .|..|. |. ..||. .|| 
........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpeQyr

FLHQCILDLLS
||....| ||.
flyefellllk

0043147 (Phosphotyrosine protein) phosphatases II 2053-2254 1.6e-41 137.2 In-house 3-155 (172) alignment
Range on Protein: 2053-2254
Range on HMM: 3-155/172.0
PGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCfekgrirchqywpednkpvtvfgdivitklmedvqidwtirdlKIERH
.|||||||||...| .|..||||||||. |. |||||..|   ...|.||..                                              . 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

GDCMTVRQCNFTAWPEHGVPeNSAPLIHFVKLVRA-SRAHDTTPMIVHCSAGVGRTGVFIALDHLTqhindhD-FvDIYGLVAELRSERMCMVQNLAQYI
. . .. |  .. || |||| ... |..|.....      .  |..|||||||||||...|.. .         . ...  ||..|. |...|||  ||.
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyr

FLHQ
||..
flyy

0036282 (Phosphotyrosine protein) phosphatases II 2054-2254 3.3e-48 159.0 In-house 1-164 (174) alignment
Range on Protein: 2054-2254
Range on HMM: 1-164/174.0
GSDYINASYISGYLCPNEFIATQGPLPgtvgdFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEdnkpvtvfgdivitklmedvqidwtirdlkiERHG
||||||||..... .....||.||||.     ||.|..| . .|.|||....|.|. .|..||||                                |. 
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lred

DCMTVRQCNFTAWPEHGVPENSApLIHFVKLVRASRAH-DTTPMIVHCSAGVGRTGVFIALDHLTQHINdHDFVDIYGLVAELRSERMCMVQNLAQYIFL
   .. |  .. || ||||. |  |..|||.|.  ... .  |..|||||||||||...|.. . ...  ...||.. ||.|||. |..|||.  ||.||
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

HQ
..
yy

0051082 (Phosphotyrosine protein) phosphatases II 2054-2256 7.2e-35 115.1 In-house 2-149 (151) alignment
Range on Protein: 2054-2256
Range on HMM: 2-149/151.0
GSDYINASYISGYlcpneFIATQGPLPgtvgDFWRMVWETRAKTLVMLTQCFEKGriRCHQYWPEDNkpvtvfgdivitklmedvqidwtirdlkierhg
 |||||.||. |.     .....|||.    ||.....|   || |.|.. .| |   |..|.|| .                                 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

dcMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRAsraHDTTPMIVHCSAGVGRTGVFIALDHLTQHindhdfVDIYGLVAELRSERMCMVQNLAQYIFLH
  ..|... .. ||..|.|.. . ...|..|...   ..  |..||||||.||||...||. . ..      |...  ..|.|. |. .||   |..|..
..ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

QCI
...
fal

0049260 (Phosphotyrosine protein) phosphatases II 2062-2254 2e-38 126.8 In-house 1-144 (152) alignment
Range on Protein: 2062-2254
Range on HMM: 1-144/152.0
YISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWpednkpvtvfgdivitklmedvqidwtirdlkierhgdcmtvrQC
.|.||  |.||||||||.| |. |||||..|  ..|.||||...|.|.. |.||.                                           | 
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

NFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTqhindhDFVDIYGLVAELRSERMCMVQNLAQYIFLHQ
 .. || ||||..|  |. ......  . ..  | .|||||||||||...|.. .         |...  || .|. |...|.|  |..||..
lhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2064-2131 2.1e-11 37.8 In-house 230-293 (440) alignment
Range on Protein: 2064-2131
Range on HMM: 230-293/440.0
SGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKgriRCHQYWPEDNKPVTvFGDIVI
 ||   | ||||| ||  || ||||.| . |  |..|| |  .|    |  ||| . . || || . .
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvt.fgpftv

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 2071-2254 4.1e-23 76.6 In-house 5-197 (198) alignment
Range on Protein: 2071-2254
Range on HMM: 5-197/198.0
EFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKIERHGD----CMTVRQCNFTAW
 .|||| ||  |. |||.||||| .  .||. .   .       |||  .  .. .| . .|     .. |.||  | .            . . .||.|
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PEHGVPeNSAPLIHFVKLVRA-SR---AHDTTPMIVHCSAGVGRTGVFIALDHLT-QHIN-DHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQ
 |.  | | | .. ||   |  |.       .|.||||| | | ||||.|||     | .     ||.. .   ||  |  ..  | .| |..|
kekttp.nvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 2071-2254 4.5e-23 76.5 In-house 6-198 (199) alignment
Range on Protein: 2071-2254
Range on HMM: 6-198/199.0
EFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKIERHGD----CMTVRQCNFTAW
 .|||| ||  |. |||.||||| .  .||. .   .       |||  .  .. .| . .|     .. |.||  | .            . . .||.|
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PEHGVPeNSAPLIHFVKLVRA-SR---AHDTTPMIVHCSAGVGRTGVFIALDHLT-QHIN-DHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQ
 |.  | | | .. ||   |  |.       .|.||||| | | ||||.|||     | .     ||.. .   ||  |  ..  | .| |..|
kekttp.nvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 2072-2265 4.7e-22 73.3 In-house 39-226 (255) alignment
Range on Protein: 2072-2265
Range on HMM: 39-226/255.0
FiatqgplpgTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVI--TKLMEDVQIDWTIRDLKIERHGDCMTVRQCNFTAWPEH
.         ||  |....  |.....|||.   |.|. .|..|.| .     .. |. .  || . || .      ... .     ||.  ... |.|.
l.........tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWiek

GVPENSAPLIHFVKLVRASRahdttPMIVHCSAGVGRTGVFIALDHLTQ----HINDHDFVDI--YGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNK
  ||..  . . .|.|| |.     ...||||.|.||.  |.  . . |     ..  . |..    |. ||||.| . ...  |  |    .|||.  |
naPelareilnilkvvrdsk.....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfpk

GS
| 
ge

subfamily_hpo-7_pd Subfamily hpo-7 2080-2265 5e-20 66.5 In-house 44-232 (263) alignment
Range on Protein: 2080-2265
Range on HMM: 44-232/263.0
PGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITklMEDVQIDWTIRDLKIER----HGDCMTVRQCNFTAWPEHGVPENS
  |.  |....  |.....|||.   |.|. .| .|.| .     .. .. ..    .|| |  .. |..           ||..  .. |.|.  ||..
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvc..ttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpela

APLIHFVKLVRASRahdttPMIVHCSAGVGRTGVFIALDHLTQ----HINDHDFVDI--YGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGS
   .. .|..| |.     ...||||.|.||.  |   . . |     ..  . |..    |. ||||.| . ...  |  |    .||.. |  .
reilnilkvarnsk.....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfa

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 2081-2263 3.9e-18 60.0 In-house 102-291 (302) alignment
Range on Protein: 2081-2263
Range on HMM: 102-291/302.0
GTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLM--EDVQ-----IDWTIRDLKIERH----GDCMTVRQCNFTAWPEH
 |.  .| .. . .    | |..  |..  .| .|. .. . .  ||   .. .   .|..      . ..  ..|. .       .||    |.|||.|
stlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdh

GVPENSAPLIHFVKLVRASRahdtTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNK
| |... . .. .|   . .    . ..||||||||||| ..|. .  |    ..  |.  .|  .|. |   ||.  | |.|  |.   | .|
Gapkeaytaldilkfcesyk....knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkglmek

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 2083-2264 1.4e-06 21.2 In-house 131-313 (346) alignment
Range on Protein: 2083-2264
Range on HMM: 131-313/346.0
VGDFWRMVWETRAKtLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKI--ERHGDCMTVRQCNFTAWPEHGVPENSAPLIH
| ||| |... . . || |    .| .      . ..|      | ..| .   ||  |     ...  |   | . ..    . |     | .. |.|.
vedfwymiyqeqih.lvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapwkhlqqppktlpiik

FVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKG
...   . .   .. . |    | ||.  ||   .  . .|.    .|. .. ... .|   |. .|||  ..  ..| .. | 
mihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyiarkr

0048076 (Phosphotyrosine protein) phosphatases II 2142-2259 5.2e-24 80.0 In-house 31-142 (145) alignment
Range on Protein: 2142-2259
Range on HMM: 31-142/145.0
WTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDtTPMIVHCSAGVGRTGVFIALDHLTQhindHDfVDIYGLVAELRSERMC
.|. .|  |...   .. |  .. || ||||. .. |..|...... ....  |..|||||||||||...|.. . .    .. |...  ....|| |..
ttvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpg

MVQNLAQYIFLHQCILDL
.|.|  |..||....| |
avpnpgqlrflyefelel

0048179 (Phosphotyrosine protein) phosphatases II 2144-2254 1.2e-21 72.4 In-house 33-139 (144) alignment
Range on Protein: 2144-2254
Range on HMM: 33-139/144.0
IRDLKIERHGDCMT--VRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDtTPMIVHCSAGVGRTGVFIALDHLTqhindH-DfVDIYGLVAELRSERM
. .|  |.. ....  . |  .. || ||||. .. |..|...... ....  |..|||||||||||...|.. .      . . ....  .|..|| |.
vinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk.....klg.lsleealalvrsrrp

CMVQNLAQYIFLHQ
..|.|  |..||..
gavpnpgqlrfLle

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2155-2260 5e-20 66.2 In-house 88-194 (440) alignment
Range on Protein: 2155-2260
Range on HMM: 88-194/440.0
CMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAH-DTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLH
. |..| .. .||..|||. ..|...... |  |. .    |..||||||.||||| ||.| . .. .  | .||. ..  .|..|  |||   || |.|
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

QCILDLL
...|. |
eavlegl

PTPc_DSPc_SM00012 2157-2257 7.8e-33 108.2 In-house 1-104 (105) alignment
Range on Protein: 2157-2257
Range on HMM: 1-104/105.0
TVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHD--TTPMIVHCSAGVGRTGVFIALDHLTQHINDH-DFVDIYGLVAELRSERMCMVQNLAQYIFLH
||..  .|.||.|||||.| ....... |. .. .   ..|..|||||||||||.|.||| | |..... ..|||. .| |||..|. |||...||.||.
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

QCIL
...|
rall

subfamily_PTPDC1_pd Subfamily PTPDC1 2159-2213 7.4e-06 20.5 In-house 84-134 (182) alignment
Range on Protein: 2159-2213
Range on HMM: 84-134/182.0
RQCNFtAWPEHGVPENSApLIHFVKLVRASRAHDttPMIVHCSAGVGRTGVFIAL
  .|| .|...||.     ..  ||.|  .  ..   . ||| || ||||| || 
yvynf.gwkDygvasler.iLdivkvvafalqeg..kvavhChaGlGrtGvliac

0038934 (Phosphotyrosine protein) phosphatases II 2165-2213 3.6e-06 22.3 In-house 86-135 (194) alignment
Range on Protein: 2165-2213
Range on HMM: 86-135/194.0
AWPEHGVPENSAPLIHFVKLVRASRAHD-TTPMIVHCSAGVGRTGVFIAL
 .|..|.. . . | .|..||    . |      ||| ||.||||...| 
pfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa

subfamily_CG42327_pd Subfamily CG42327 2187-2256 9.8e-13 42.4 In-house 241-311 (319) alignment
Range on Protein: 2187-2256
Range on HMM: 241-311/319.0
ASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDH-DFVDIYGLVAELRSERMCMVQNLAQYIFLHQCI
... ..  |..|||| ||||||. || |   .....    |||  ||  .| .|   |..  || |... .
sgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 2189-2259 3.9e-16 53.7 In-house 258-343 (350) alignment
Range on Protein: 2189-2259
Range on HMM: 258-343/350.0
RAHDTTPMIVHCSAGVGRTGVFIALDHLTQ----------HINDHDFV-----DIYGLVAELRSERMCMVQNLAQYIFLHQCILDL
    ..|..|||||||||||....||.| .          . .  |        |  .| |||. |. ||||| |.||.....| .
dnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfy

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 2191-2260 4.7e-12 39.9 In-house 263-344 (349) alignment
Range on Protein: 2191-2260
Range on HMM: 263-344/349.0
HDTTPMIVHCSAGVGRTGVFIALDHLTQ--HINDHDFV----------DIYGLVAELRSERMCMVQNLAQYIFLHQCILDLL
 ......|||||| |||||.. || | .  .   ....           |.  | |||  |. |||||||.|......|  .
dqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 2193-2258 4.5e-12 40.4 In-house 228-293 (297) alignment
Range on Protein: 2193-2258
Range on HMM: 228-293/297.0
TTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILD
 ....|||||||||.|| .  | . . .  .   |.  ..  ||..|  .|| | |. .|.. .| 
nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 2196-2258 9.1e-13 42.4 In-house 1-63 (69) alignment
Range on Protein: 2196-2258
Range on HMM: 1-63/69.0
MIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILD
|.||||.| |||| |||.      |    .|||.  |  .|  |  || |  .|||.|  . .
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalve

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 2197-2259 1.5e-11 38.5 In-house 1-63 (69) alignment
Range on Protein: 2197-2259
Range on HMM: 1-63/69.0
IVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDL
.||||.| |||| |||.      |    .|||.  |  .|  |  || |  .|.|.|. . . 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvea