Gene DSP19 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP19
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP012_AA protein Get Run
MbreP012_AA_52-165 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP19_pd Subfamily DSP19 45-166 7.3e-47 153.5 In-house 2-121 (152) alignment 
Range on Protein: 45-166
Range on HMM: 2-121/152.0
FVVDQRQDLNVGYATDRVLFGSQDVAASRFTLDQLGVTHVLNVGVGIPCFFPEDLHYLKLELLDVPEASLLTILQPALDFVRNALDIDpaNRVFIHCNAG
||.|...||.||....|...|||||||.. .|.. ..||.|||..|.|..||.|..||..|.||.||..||..|. ||||...|.. |  ..|..|||||
fveDlkedlevgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskd..gavlvHCnAG

VSRSASVAMAYLITDHESDLER
|||||||..|||....|..||.
vSRsasvviaylmkkeelslee
0044763 (Phosphotyrosine protein) phosphatases II 45-164 4.1e-22 74.1 In-house 13-140 (178) alignment 
Range on Protein: 45-164
Range on HMM: 13-140/178.0
FVVDQRQDLNVGYATDRVLFGSQDVAASRFTLDQLGVTHVLNVGVGIPCFFPED---------LHYLKLELLDVPEASLLTILQPALDFVRNALDiDPAN
  .   . .|. . ..... ||.  |. .  | .||.||..|.   ....|...         ..||.. . | .. .|| ... ...|...||| .. .
eglersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeald.ekgg

RVFIHCNAGVSRSASVAMAYLITDHESDL
.|..||.|||.||.....|||.  .  .|
pvlVHCsaGvgRsgtlvaaylmkklglsl
0041856 (Phosphotyrosine protein) phosphatases II 50-165 5.6e-19 63.9 In-house 14-140 (182) alignment 
Range on Protein: 50-165
Range on HMM: 14-140/182.0
RQDLNVGYATDRVLFGSQDV--------------AASRFTLDQLGVTHVLNVGvgIPCFFPEDL-----HYLKLELLDVPEASlltiLQPALDFVRNALD
 ....  | ..... ||.                |.   .| .||.|...|.    .. .||.|     .||.|   | .  .    |. .|||.. .|.
dhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd....ldelldfieevle

idPANRVFIHCNAGVSRSASVAMAYLITDHESDLE
  . ..|..||.|||.|......|||.  .. .||
..eggpvlVHCsaGvgRtgtlvaaylmkklgvsle
0045098 (Phosphotyrosine protein) phosphatases II 52-160 3.5e-18 61.4 In-house 19-232 (278) alignment 
Range on Protein: 52-160
Range on HMM: 19-232/278.0
DLNVGYATDRVLFGSQD-----------------------------------------VAASRFTLDQLGVTHVLNVG----------------------
  ...  |. .. |..|                                         ||.   .| .||.|.....                       
lgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggslty

------------------------------VGIPCFFPEDLHYLKLELLDVPEASLLTILQPALDFVRNALD------------IDPANRVFIHCNAGVS
                               ...... . ||||  .  .||. ..|. .. .|.|.|.||.            .|. ..|..||.|||.
gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvg

RSASVAMAYLITDH
|.. ...|||. ..
RtGtlvaaylmlel
0046846 (Phosphotyrosine protein) phosphatases II 52-161 9.8e-16 53.5 In-house 9-137 (176) alignment 
Range on Protein: 52-161
Range on HMM: 9-137/176.0
DLNVGYATDRVLFGSQD----------VAASRFTLDQLGVTHVLNVGVGI-----------PCFFPEDLHYLKLELLDVPEASLlTILQPALDFVRNALD
||.. | ......||            .|.    | .||.|.|.|.   .           | .  ....|| |   |    .| ..|. .|.|.|.||.
dldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealk

IDpaNRVFIHCNAGVSRSASVAMAYLITD-HE
 .  ..| .|| ||..|.. ...|||.   . 
eg..gpvlVHCsaGigRtgtlvaayllelekg
0037934 (Phosphotyrosine protein) phosphatases II 52-164 5.9e-14 47.7 In-house 36-209 (243) alignment 
Range on Protein: 52-164
Range on HMM: 36-209/243.0
DLNVGYATDRVLFGSQ--------DVAASRFTLDQLGVTHVLNVGVGI---------------------------------------------PCFFPED
..|  | |.|.  ...        |.|.    | .||.|.....   .                                             . .. ..
nanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlv

LHYLKLELLD--VP--EASLLTILQPALDFVRN---ALDIDPANRVFIHCNAGVSRSASVAMAYLITDH-ESDL
 ||. |   |  ||   ..|| .|. . .|...   .| .|. ..| .|| |||.|.. ...|||. .. . ||
ihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdl
0051082 (Phosphotyrosine protein) phosphatases II 53-162 2.7e-16 55.0 In-house 6-119 (151) alignment 
Range on Protein: 53-162
Range on HMM: 6-119/151.0
LNVGYATDRVLFGSQDVAASRFTLDQLGVTHVLNVGV-----GIPCFFPE-DLHYLKLELLDVPEASLLTILQPALDFVRNALDiDPANRVFIHCNAGVS
.| .| |.... ...  |.   .| .||.....|.         |...|| ....| . .|| |. .| .... .|.|.. .|| .. . |..||.||..
infsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkg

RSASVAMAYLITdHES
|.. ....||.  .  
RTGtlvalylml.lgv
0036282 (Phosphotyrosine protein) phosphatases II 53-161 2.8e-16 55.1 In-house 10-131 (174) alignment 
Range on Protein: 53-161
Range on HMM: 10-131/174.0
LNVGYATDRVLFGSQDVAaSRFTLDQLGVTHVLNVGVGI---------------PCFFPEDLHYLKLELLDVPEASLLTiLQPALDFVRNALDIDPANRV
|.. | |.|.. |.   |     | .||.|.|...   .                 . .....||.|   |  . .| . |. ...||..||  || . |
ldlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpv

FIHCNAGVSRSASVAMAYLITDHE
 .||.|||.|.. ...|||.  . 
lVHCsaGvgRtGtlvaaylmlrgl
subfamily_DSP3_pd Subfamily DSP3 58-164 2.6e-21 69.9 In-house 14-127 (162) alignment 
Range on Protein: 58-164
Range on HMM: 14-127/162.0
ATDRVLFGSQDVAASRFTLDQLGVTHVLNVGVGI-------PCFFP-EDLHYLKLELLDVPEASLLTILQPALDFVRNALDIdPANRVFIHCNAGVSRSA
 ....  | ..||  .  | .||.|||||   |        . |.   ...|| ||. ||||. | .  ..| .|...||.  .  .|..||..||||||
vypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsq.kegkvlvhcvvGvsRsa

SVAMAYLITDHESDL
 ...|||.  .. .|
tlvlayLmirrkmtl
subfamily_DSP8_pd Subfamily DSP8 58-159 1.2e-15 51.5 In-house 18-118 (159) alignment 
Range on Protein: 58-159
Range on HMM: 18-118/159.0
ATDRVLFGSQDVAASRFTLDQLGVTHVLNVGVGIPC-FFPEDLHYLKLELLDVPEASLLTILQPALDFVRNALDIdpANRVFIHCNAGVSRSASVAMAYL
 .. . .||| .. |. .|..||...|||.    |   . .. ..|.. . |  .  || ... ...|.  |       ||..|. || ||||.||.||.
ilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkakse..ngrvlvhvlaGisrsatvaiayi

ITD
.  
mkt
subfamily_DSP1_pd Subfamily DSP1 59-165 3.5e-24 79.7 In-house 22-126 (163) alignment 
Range on Protein: 59-165
Range on HMM: 22-126/163.0
TDRVLFGSQDVAASRFTLDQLGVTHVLNVGVGIPCFFPEDLHYLKLELLDVPEASLLTILQPALDFVRNALDIdpANRVFIHCNAGVSRSASVAMAYLIT
.| . .||. ||. . .|..||.|..|||   .. .|.. ..| ||.| | |.| . ........|. .. .     .|.|||.||.|||... .|||..
ldfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkk..nGkvlihCqaGisRsstlclaylmk

DHESDLE
 ..  ||
tkrvsle
0048076 (Phosphotyrosine protein) phosphatases II 59-165 6.7e-22 73.2 In-house 8-112 (145) alignment 
Range on Protein: 59-165
Range on HMM: 8-112/145.0
TDRVLFGSQDVAASRFTLDQLGVTHVLNVGVGIPCFFPEDLHYLKLELLDVPEASLLTILQPALDFVRNALDIDpaNRVFIHCNAGVSRSASVAMAYLIT
.... .||. .| .. .| .||.|.|||.   .. .......|| | . | .. .|| .|. .|.|...||. .  ..|..||.|||.|......|||. 
lpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylml

DHESDLE
 .  .||
llgvsle
subfamily_Slingshot_pd Subfamily Slingshot 59-167 1.9e-21 70.2 In-house 23-129 (169) alignment 
Range on Protein: 59-167
Range on HMM: 23-129/169.0
TDRVLFGSQDVAASRFTLDQLGVTHVLNVGVGIPCFFPEDLHYLKLELLDVPEASLLTILQPALDFVRNALDIDpaNRVFIHCNAGVSRSASVAMAYLIT
 | | .||.  |.    |.. ||...|||   |  ||||...||.. . | .|. ||.  . . .|...| . .   .|..||  |||||||. .|| . 
fdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkg..skvlvhckmGvsrsastviayamk

DHESDLERE
... .||. 
eyglsleea
0048179 (Phosphotyrosine protein) phosphatases II 59-165 1.3e-20 69.1 In-house 8-114 (144) alignment 
Range on Protein: 59-165
Range on HMM: 8-114/144.0
TDRVLFGSQDVAASRFTLDQLGVTHVLNVGVGIPCFFPEDL--HYLKLELLDVPEASLLTILQPALDFVRNALDidPANRVFIHCNAGVSRSASVAMAYL
.... .||. .| .  .| .||.|.|.|.  . .  |.|.   .||.| . | .  .||..|. .|.|...||.  . ..|..||.|||.|......|||
lpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaayl

ITDHESDLE
.  .  .||
mkklglsle
0042113 (Phosphotyrosine protein) phosphatases II 59-159 2.6e-14 48.7 In-house 51-206 (245) alignment 
Range on Protein: 59-159
Range on HMM: 51-206/245.0
TDRVLFGSQDVAASRF----TLDQLGVTHVLNVGVGI----------------------------------------------PCFFPEDLHYLKLELLD
|.... ...  . .       | .||.|.....                                                    .  |..||. |   |
tpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpd

VPEASLLTILQPALDFVRNALDIDPANRVFIHCNAGVSRSASVAMAYLI-----TD
 ....|| .|. .|.|||.||  |. ..|..||.|||.|.. ...|||.     . 
hgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqleke
PTPc_motif_SM00404 60-165 3.5e-19 64.1 In-house 7-111 (140) alignment 
Range on Protein: 60-165
Range on HMM: 7-111/140.0
DRVLFGSQDVAASRFTLDQLGVTHVLNVGVGIPCF-FPEDLHYLKLELLDVPEASLLTILQPALDFVRNAldIDPANRVFIHCNAGVSRSASVAMAYLIT
... .||.. | ..  |..||.|||.||.  ..     .. ..|...| |  .. |.  |. .|||..||  ..   .|..|| |||||||....|||..
phlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfiena..ekkggkvlVHCqaGvSRSatliiaYlmr

DHESDLE
 .. .|.
yrqlsla
subfamily_DSP12_pd Subfamily DSP12 60-165 7.9e-18 59.3 In-house 7-113 (155) alignment 
Range on Protein: 60-165
Range on HMM: 7-113/155.0
DRVLFGSQDVAASRFTLDQLGVTHVLNVGVG-IPCFFP--EDLHYLKLELLDVPEASLLTILQPALDFVRNALdiDPANRVFIHCNAGVSRSASVAMAYL
.....|.   ...  .|..|..|||| |    .| . .    ........|| ||. .|. |. |.||. .||  .  . |..||.||||||... .|||
pglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieeal..eeegavlvHCqagvSRSvtiviAYl

ITDHESDLE
.  .. .||
mkkeklsle
subfamily_LRR-DSP_pd Subfamily LRR-DSP 60-159 6.6e-15 48.9 In-house 125-222 (263) alignment 
Range on Protein: 60-159
Range on HMM: 125-222/263.0
DRVLFGSQDVAASRFTLDQLGVTHV-LNVGVgIPCFFPEDLHYLKL-ELLDVPEASLLTILQPALDFVRNALDidpANRVFIHCNAGVSRSASVAMAYLI
|.. .|..| |  .  | .|||||. | |.  .  .||. . || . .. ||.|| .   ..    |. .  .      |..|| ||||||... ..||.
dklflGgldsannksilkdlgvthillavad.fePlfPklfkylsiddiedvdeadisqhfeetnafieeGrk...kGGvlvhcraGvsrsstlvisylm

TD
  
kk
0051429 (Phosphotyrosine protein) phosphatases II 60-164 3.6e-11 38.7 In-house 21-193 (272) alignment 
Range on Protein: 60-164
Range on HMM: 21-193/272.0
DRVLFGSQDV----AASRFTLDQLGVTHVLNVGVG-----IP-CFFPEDLHYLKLELLDVPEASLLTIL-------------------------------
...|. |.      ||.  .| .||.......         .  .......|| | .||  . . | .                                
pgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagear

-----------------QPALDFVRNALDidpANRVFIHCNAGVSRSASVAMAYLITdHESD--------------L
                 .. |....  ||    ..| .||.||..|.. |....|.  .  .              |
evmhlhytdwpdhgvpqeallellellld...ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyl
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 61-159 1.1e-20 67.5 In-house 9-116 (154) alignment 
Range on Protein: 61-159
Range on HMM: 9-116/154.0
RVLFGSQDVAASRFTLDQLGVTHVLNVGVGIPCFFPED---------LHYLKLELLDVPEASLLTILQPALDFVRNALDIDPANRVFIHCNAGVSRSASV
 .  .|.| |  .. |..  ....||||.||.  |...         ..||.||| | ..  ..  |. |..|...|.     |.|..|...||||||..
flyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaal

AMAYLITD
...||.  
lisylmdk
subfamily_MKPLT_pd Subfamily MKPLT 61-160 1.5e-18 60.9 In-house 28-125 (164) alignment 
Range on Protein: 61-160
Range on HMM: 28-125/164.0
RVLFGSQDVAASRFTLDQLGVTHVLNVGVGIPCFFPEDLHYLKLELLDVPEASLLTILQPALDFVRNAldIDPANRVFIHCNAGVSRSASVAMAYLITDH
..  |  . | ..  |..| .||..||  .    ||. . ||.... |...  | . |. | .|. .|  ||   ||..||. |.|||.||..|.||. .
tlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakflada..idsGGrvlvhcvqGksrsssvtvafLiksk
subfamily_MKPLV_pd Subfamily MKPLV 61-160 1.5e-18 60.9 In-house 28-125 (164) alignment 
Range on Protein: 61-160
Range on HMM: 28-125/164.0
RVLFGSQDVAASRFTLDQLGVTHVLNVGVGIPCFFPEDLHYLKLELLDVPEASLLTILQPALDFVRNAldIDPANRVFIHCNAGVSRSASVAMAYLITDH
..  |  . | ..  |..| .||..||  .    ||. . ||.... |...  | . |. | .|. .|  ||   ||..||. |.|||.||..|.||. .
tlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakflada..idsGGrvlvhcvqGksrsssvtvafLiksk
subfamily_DSP6_pd Subfamily DSP6 61-164 5.9e-17 55.6 In-house 20-123 (158) alignment 
Range on Protein: 61-164
Range on HMM: 20-123/158.0
RVLFGSQDVAASRFTLDQLGVTHVLNVGVGIPCFFPE--DLHYLKLELLDVPEASLLTILQPALDFVRNALDIDpaNRVFIHCNAGVSRSASVAMAYLIT
.. .||.. |. . .|..|.. .||||   .| .| |  .|.||.. . |. .. | . .  |..|. .|   .  . |..|| ||.|||  |..|||. 
llylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskk..skvlvhClaGisrsvtvtlaylmk

DHESDL
 ..  |
klalsl
subfamily_DSP10_pd Subfamily DSP10 62-164 4.5e-21 69.4 In-house 21-122 (159) alignment 
Range on Protein: 62-164
Range on HMM: 21-122/159.0
VLFGSQDVAASRFTLDQLGVTHVLNVGVGIPCFFPE-DLHYLKLELLDVPEASLLTILQPALDFVRNALDIdpANRVFIHCNAGVSRSASVAMAYLITDH
...||.  ||.  .||.|..|.||||   .|..| | .|.| .... |  .  | .  . ||.|. .|      .||..||.||.||||.|..|||..  
LflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkk..gsrvLvhCqaGisrsatvviaYlmkhl

ESDL
.  |
nlsl
subfamily_DSP14_pd Subfamily DSP14 62-165 2.6e-18 60.5 In-house 13-114 (157) alignment 
Range on Protein: 62-165
Range on HMM: 13-114/157.0
VLFGSQDVAASRFTLDQLGVTHVLNVGVGIPCFFPEDLHYLKLELLDVPEASLLTILQPALDFVRNALdiDPANRVFIHCNAGVSRSASVAMAYLITDHE
 || |  .| |. .|.. ..|...|| | .|    .|....|. . | |||.| . .... | ....     . .. .|| ||||||||...|||.  ..
sLflsgvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevk..kkggktlvhCvaGvSRSAslclaylmkyek

SDLE
  |.
lsLr
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 63-164 2.9e-16 53.3 In-house 16-116 (148) alignment 
Range on Protein: 63-164
Range on HMM: 16-116/148.0
LFGSQDVAASRFTLDQLGVTHVLNVGVGIPCFFPED-LHYLKLELLDVPEASLLTILQPALDFVRNALDidPANRVFIHCNAGVSRSASVAMAYLITDHE
  ||.  ||.  .| .||||.. |     .  . .  ..||...| | |.  | .| ... .|||.| |    .|| .|.. |||||. .|...||  ..
FlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakd..eGrrvLvhlqmGvsrssalallwlidfkr

SDL
  |
vsl
PTEN_1 64-158 9.4e-16 53.2 In-house 51-154 (196) alignment 
Range on Protein: 64-158
Range on HMM: 51-154/196.0
FGSQDVAASRFTLDQLGVTHVLNVGVGIP---------CFFPEDLHYLKLELLDVPEASLLTILQPALDFVRNALDIDPANRVFIHCNAGVSRSASVAMA
    |||| . .|.. |.|.|.|.  . .          || ... ||...  | .  ||  ..  . .|   .|  .. | | .|| ||..||. |..|
gslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaa

YLIT
||. 
yLmy
0049260 (Phosphotyrosine protein) phosphatases II 64-164 2.1e-15 52.2 In-house 17-118 (152) alignment 
Range on Protein: 64-164
Range on HMM: 17-118/152.0
FGSQDVAASRFTLDQLGVTHVLNVGVGIPC---FFPEDLHYLKLELLDVPEASLLTILQPALDFVRNAlDIDPANRVFIHCNAGVSRSASVAMAYLITdH
 |....|     | .||.|.....    .    ....  .|| |   | .  .|  .|. .|.|.. .  .|. ..|..|| |||.|.. ...|||.  .
pgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml.l

ESDL
  .|
gvsl
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 64-158 3.8e-07 23.3 In-house 8-104 (145) alignment 
Range on Protein: 64-158
Range on HMM: 8-104/145.0
FGSQDVAASRFTLDQLGVTHVLNVGVGIP----CFFPEDLHYLKLELLDVPEASLLTILQPALDFVRNALDidPANRVFIHCNAGVSRSASVAMAYLIT
 ||   | .  ||..||.. ..|.  |          |... | .   |.    |   ..   ||.    .      ||.|| |||||| .|..|.|. 
vgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgke..egagvfvhcmagvsrsvtvsvaflmk
0043147 (Phosphotyrosine protein) phosphatases II 65-162 1.1e-18 63.0 In-house 29-127 (172) alignment 
Range on Protein: 65-162
Range on HMM: 29-127/172.0
GSQDVAASRFTLDQLGVTHVLNVGvG----IPCFFPEDLHYLKLELLDVPEAsLLTILQPALDFVRNALDIDPANRVFIHCNAGVSRSASVAMAYLITdH
.. ..|  .  | .||.||..|.  .     .........|| |   | .   || .|. .|.|....| ..| ..| .|| |||.|.. ...|||.  .
lrntladfwrmlkelgithivnlt.ellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.l

ES
  
gl
subfamily_DSP15_pd Subfamily DSP15 65-159 6.5e-14 46.3 In-house 12-103 (151) alignment 
Range on Protein: 65-159
Range on HMM: 12-103/151.0
GSQDVAASRFTLDQLGVTHVLNVGVGIPCFFPEdLHYLKLELLDVPEASLLTILQPALDFVRNALDiDpANRVFIHCNAGVSRSASVAMAYLITD
|   ..  .  |..  .||.|.|      .... ..|. ... | |.| | .... . .|. ..      . |..|| ||||||. ...|||.| 
gnfrdskdeelLkeknithilsvhdnakkllkd.ieYkciaasDtpsaklskffkesvefihkcRl.k.eenvlvhClaGvsRsvtlvvaYlmtv
DSPc Dual specificity phosphatase, catalytic domain 66-163 2.4e-17 58.1 Pfam-A 5-102 (133) alignment 
Range on Protein: 66-163
Range on HMM: 5-102/133.0
SQDVAAsRFTLDQLGVTHVLNVGVGIPC---FFPEDLHYLKLELLDVPEASLLTILQPALDFVRNAldIDPANRVFIHCNAGVSRSASVAMAYLITDHES
|.  |     |..||.|.|.||   .|    . ... .||.. . |  |. .   |. | .|...|  ..  ..|..||.||.||||....|||.. .. 
skstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefieka..eqkgkkvlVHCqaGisRSatliiaYlmktknl

D
.
s
DSPc Dual specificity phosphatase, catalytic domain 66-163 2.4e-17 58.1 In-house 5-102 (133) alignment 
Range on Protein: 66-163
Range on HMM: 5-102/133.0
SQDVAAsRFTLDQLGVTHVLNVGVGIPC---FFPEDLHYLKLELLDVPEASLLTILQPALDFVRNAldIDPANRVFIHCNAGVSRSASVAMAYLITDHES
|.  |     |..||.|.|.||   .|    . ... .||.. . |  |. .   |. | .|...|  ..  ..|..||.||.||||....|||.. .. 
skstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefieka..eqkgkkvlVHCqaGisRSatliiaYlmktknl

D
.
s
0040439 (Phosphotyrosine protein) phosphatases II 69-158 5e-14 48.0 In-house 67-208 (249) alignment 
Range on Protein: 69-158
Range on HMM: 67-208/249.0
VAASRFTLDQLGVTHVLNVGVGIPC-------------------------------------------FFPEDLHYLKLELLDVPEASLLTILQPALDFV
|.. .  | .||.|.....    ..                                            ..|....| .  .| |. ..   ....|||.
vedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfi

RNALDID----PANRVFIHCNAGVSRSASVAMAYLI-----T
. ....     . ..|..||.|||.|.. ...|||.     .
eavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlek
0038934 (Phosphotyrosine protein) phosphatases II 74-160 4.2e-11 38.3 In-house 50-141 (194) alignment 
Range on Protein: 74-160
Range on HMM: 50-141/194.0
FTLDQLGVTHVLNVGVGIPCFFPEDLHYLKLELLDVPEAS-----LLTILQPALDFVRNALDIDPANRVFIHCNAGVSRSASVAMAYLITDH
..| . ....|...    ... ||... ...| |. |  .      | ||.  ||.|   |. || . | .|| ||..|.. .. ||||  .
lkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrl
0045450 (Phosphotyrosine protein) phosphatases II 76-160 1.9e-12 43.0 In-house 127-260 (307) alignment 
Range on Protein: 76-160
Range on HMM: 127-260/307.0
LDQLGVTHVLNVGVGIP-------CFFPED---------------------LHYLKLELLDV-----------------PEASLLTILQPALDFVRNALD
| ..|||.....   ..        ..|..                     .....||. |                  |. .. . ....|||.. ...
lweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrk

----IDPANRVFIHCNAGVSRSASVAMAYLITDH
     .. ..| .||.|||.|......|||. ..
aleelpkggpvlVHCsaGvgRtGtfiaaylmlrq
subfamily_STYX_pd Subfamily STYX 76-158 6.1e-10 32.4 In-house 35-120 (166) alignment 
Range on Protein: 76-158
Range on HMM: 35-120/166.0
LDQLGVTHVLNVGVGI-----PCFFPEDLHYLKLELLDVPEASLLTILQPALDFVRNALDIdpANRVFIHCNAGVSRSASVAMAYLIT
| . |.||.. .   |        ||....|| |.. | .   ..  |    .|. ..|.     .|..| |||.||||.. .||.. 
lkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqk..ggkvlvhgnagisrsaalviayime
0040438 (Phosphotyrosine protein) phosphatases II 78-159 2.2e-12 42.3 In-house 108-239 (317) alignment 
Range on Protein: 78-159
Range on HMM: 108-239/317.0
QLGVTHVLNVGVGIPC---------------------------FFPEDLHYLKLELLDV----------------PEASLLTILQPALDFVRNALDI--D
..|||.....    ..                           .  .. ....||. |                 |. ..   ... |||.. . .   |
eqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealed

PANRVFIHCNAGVSRSASVAMAYLI-----TD
| . | .||.|||.|......|||.     . 
pggpvlVHCsaGvgRtGtfiaaylmleqleke
0043336 (Phosphotyrosine protein) phosphatases II 78-158 1.2e-10 36.9 In-house 110-239 (278) alignment 
Range on Protein: 78-158
Range on HMM: 110-239/278.0
QLGVTHVLNVG-----------------------------------------------VGIPCFFPEDLHYLKLELLDVPEasLLTILQPALDFVRNALD
.||||.....                                                   ....   .|||.    .|||   |..|.  | .||.||.
elgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpe..slsllldflkavreale

iDPANRVFIHCNAGVSRSASVAMAYLI-----T
 |. . | .||.|||.|.. ....||.     .
.dsngpvlVHCsaGvgRTGtfialyllleqlek
subfamily_STYXL1_pd Subfamily STYXL1 78-165 1.8e-10 34.3 In-house 35-123 (157) alignment 
Range on Protein: 78-165
Range on HMM: 35-123/157.0
QLGVTHVLNVGVGIPCFF---PEDLHYLKLELLDVPEASLLTILQPALDFVRNALDidPANRVFIHCNAGVSRSASVAMAYLITDHESDLE
 | |  ..||      ..   ..  . |.... |..|| ||. |. | .|. .       . |..  | |.||||.|..|||.  ..  |.
dlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkk..egevvlvfsnkGisrsaaviiaylmyskkitlk
0036941 (Phosphotyrosine protein) phosphatases II 78-160 2.4e-10 35.7 In-house 100-241 (297) alignment 
Range on Protein: 78-160
Range on HMM: 100-241/297.0
QLGVTHVLNVG-------VGIPCFFP------------------------EDLHYLKLELLD----------------VPEASLLTILQPALDFVRNALD
...||.....        .  . ..|                        .| .. .||..|                 |. .. .  .. |||.. ...
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk

ID----PANRVFIHCNAGVSRSASVAMAYLI--------TDH
.     . ..| .||.|||.||.....|.|.        . .
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeg
0049772 (Phosphotyrosine protein) phosphatases II 94-161 4.1e-16 55.1 In-house 175-240 (314) alignment 
Range on Protein: 94-161
Range on HMM: 175-240/314.0
FFPED-LHYLKLELLDvPEASLLTILQPALDFVRNAldiDPANRVFIHCNAGVSRSAS-VAMAYLITDHE
.|..  ..|| . . | ..| || ... .|.|...|   |. ..|..||.||..|... |..|||.  . 
lferlgikylripvpD.gsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllg
0039614 (Phosphotyrosine protein) phosphatases II 97-158 3.6e-11 38.5 In-house 184-251 (297) alignment 
Range on Protein: 97-158
Range on HMM: 184-251/297.0
EDLHYLKLELLDVPEASLLTILQPALDFVRNALDID-PANRVFIHCNAGVSRSASVAMAYLI-----T
.  |.. .   |    ..|..|. .|..||.||  . . ..| .||.|||.|......|||.     .
tvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlek
subfamily_Laforin_pd Subfamily Laforin 97-157 7.3e-06 19.0 In-house 75-133 (183) alignment 
Range on Protein: 97-157
Range on HMM: 75-133/183.0
EDLHYLKLELLDVPEASLLTILQPALDFVRNALdiDPANRVFIHCNAGVSRSASVAMAYLI
| | |. | . |.   | .  |  |. ..   |  .   .|..|||||| ||...   .| 
eglayiwlptedlstesrvenlpqavyllhall..ekghivyvhcnagvgrstaivcgflq
subfamily_PTPMT1_pd Subfamily PTPMT1 98-165 1.2e-11 39.4 In-house 73-138 (171) alignment 
Range on Protein: 98-165
Range on HMM: 73-138/171.0
DLHYLKLELLDVPEASLLTILQPALDFVRNALDidPANRVFIHCNAGVSRSASVAMAYLITDHESDLE
....|.|.  |. ||  |  |. ...|...  .    .||..||.|| .|||... .||.. .. ..|
gveqlqlatvDfteapdleklekgvefiekvas..kgkrvYvHCkaGrgRsatlvacylmkkeklspe
0046845 (Phosphotyrosine protein) phosphatases II 99-160 8.3e-08 27.4 In-house 170-230 (284) alignment 
Range on Protein: 99-160
Range on HMM: 170-230/284.0
LHYLKLELLDVP--EASLLTILQPALDFVRNaldIDPANRVFIHCNAGVSRSASVAMAYLITDH
.||..    .||   ..||..|. . .. .|   ... . . .|| |||.|.. .....|. ..
fhytswpdhgvppspedlleflrlvrellen...lpgggpivVHCsaGvgRtGtfialdllleq
PTPc_DSPc_SM00012 99-160 3e-07 25.9 In-house 5-65 (105) alignment 
Range on Protein: 99-160
Range on HMM: 5-65/105.0
LHYLKLELLDVPEASlltilQPALDFVRNALDIDP----ANRVFIHCNAGVSRSASVAMAYLITDH
.||..     ||| |     .. |...|.  .       .. | .|| |||.|.. ....... ..
yhytgwpdhgvPees.....dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqq
0051299 (Phosphotyrosine protein) phosphatases II 105-159 1.7e-08 29.7 In-house 188-244 (288) alignment 
Range on Protein: 105-159
Range on HMM: 188-244/288.0
ELLDVPEASLLTILQPALDFVRNALDI--DPANRVFIHCNAGVSRSASVAMAYLITD
  .. |. .  . ... |||.| . .   .. . | .||.|||.|.. .....|. .
hytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllle
0050432 (Phosphotyrosine protein) phosphatases II 107-159 1.2e-07 26.9 In-house 205-262 (308) alignment 
Range on Protein: 107-159
Range on HMM: 205-262/308.0
LDVPEASLLTILQPALDFVRNALDIDPANRVFIHCNAGVSRSASVAMAYLI-----TD
.. |. .  . ... |||.. . .  | . . .||.|||.|.. .....|.     ..
tnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqleke
0047943 (Phosphotyrosine protein) phosphatases II 109-159 3.2e-08 28.8 In-house 176-235 (273) alignment 
Range on Protein: 109-159
Range on HMM: 176-235/273.0
VPEAS---LLTILQPALDFVRNALDID-PANRVFIHCNAGVSRSASVAMAYLI-----TD
 |. .    |..|   ...||.||  .   . | .||.|||.|........|.     . 
wpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqleke
subfamily_PTEN_pd Subfamily PTEN 112-166 3.7e-07 25.3 In-house 92-146 (184) alignment 
Range on Protein: 112-166
Range on HMM: 92-146/184.0
ASLLTILQPALDFVRNALDIDPANRVFIHCNAGVSRSASVAMAYLITDHESDLER
.  | .|..... ... |. |. | | .||.||  |.  . .|||.. .  . ..
ppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekae
subfamily_MSG5_pd Subfamily MSG5 135-165 1.8e-06 21.2 In-house 100-130 (165) alignment 
Range on Protein: 135-165
Range on HMM: 100-130/165.0
NRVFIHCNAGVSRSASVAMAYLITDHESDLE
.....||. |.|||||. .||..  ..  |.
kkilvhcqcglsrsaslivayimkyynlslr