Gene PTPDC1-2 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily PTPDC1
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP015_AA protein Get Run
MbreP015_AA_384-530 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
PH PH domain 59-151 2.2e-09 27.8 Pfam-A 4-103 (104) alignment 
Range on Protein: 59-151
Range on HMM: 4-103/104.0
EGHLLKRGkNTNSAWRRRYLILFDSMIEYRRSQR---DADPAGTIQLKGARLNISKTPD-----PSMDLLEISSPSQARMYLLQGGPLLIREWAQAIRQQ
|| |||.. . .. |..||..|... ..| .|.    ...| |.|.|..... . ....     .|   .||. ... . .|    .   ..| ||... 
eGyllkks.ellktwkkryfvLtsnyLlyfksskkksykapkgsiplndctvkkasstkfgaqkesnnyfeitfknvesyllsaeseeerkrWvqalknl

I
.
l
PTEN_1 365-514 1.2e-27 92.0 In-house 4-157 (196) alignment 
Range on Protein: 365-514
Range on HMM: 4-157/196.0
GCQYCGDLERWLHNDQAIPGIFSTWITNDILALARPTQRgVDEFGLLDKLVESRVRVLINLEDHGEHANCGQGNLP--GGFSYDLDAFAARGVAVHLFGW
.. .. . ...|.. ..  ......|. .  | .|| ..   . ||. . ... .. | ||. .| .. .   . .  .|.||||. | ..|| .. |..
lskrsskknlalptelldltyitsriiamgkapsrpllq.eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpi

ADYGVPSMQTALTMVKVAAQALDL---QVAVAVHCHAGLGRTGMLIACILVYVLK
 |.|.||..  . ..|.....| .   . .|.|||.|||||.|...|. |.|  |
eDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk
subfamily_CDC14_pd Subfamily CDC14 371-515 1.9e-12 41.7 In-house 157-291 (328) alignment 
Range on Protein: 371-515
Range on HMM: 157-291/328.0
DLERWLHNDQAIPGIFSTWITNDILALARPTQRGVDEFGL--------LDKLVESRVRVLINLEDHgehancgqgnlpggfSYDLDAFAARGVAVHLFGW
|||.. . ...  | |.. . . .|||| | ..   | |         |.   . .|. .. |  .                ||   | . |.. .   .
dleeYekyervenGDfnwivPdkflalagPhnkskledgyplhaPeklleyfrknnvttvvrLnkk...............lYdakkftdaGfdhkDlff

ADYGVPSMQTALTMVKVAAQAldlQVAVAVHCHAGLGRTGMLIACILVYVLKL
.| ..|| .    ....| .|   . |.||||.||||||| |||| |..  ..
iDGstPsdaivkkfleiaeka...eGaiavhCkaGLGrtGtLiacylmkhyrf
subfamily_PTPDC1_pd Subfamily PTPDC1 374-515 1.5e-65 215.1 In-house 2-142 (182) alignment 
Range on Protein: 374-515
Range on HMM: 2-142/182.0
RWLHNDQAIPGIFSTWITNDILALARPTQRGVDEFGLLDKLVESRVRVLINLEDHGEHANCGQGNLPGGFSYDLDAFAARGVAVHLFGWADYGVPSMQTA
|| ...||| |..|||.|.||||||||.|. .||..||||..||.....|||...||||.||.|. ..||||||.|....|..|. |||.||||.|....
rwseeeqaikGlystWvtedilalarpsqeaideyklldkfkesgikavinLqekgehasCGagleesGfsYdlealmeqgiyvynfgwkDygvasleri

LTMVKVAAQALDLQvAVAVHCHAGLGRTGMLIACILVYVLKL
|..|||.|.||. . .|||||||||||||.||||.|||. .|
Ldivkvvafalqeg.kvavhChaGlGrtGvliacylvyakrl
0044763 (Phosphotyrosine protein) phosphatases II 377-515 2.2e-15 52.2 In-house 13-138 (178) alignment 
Range on Protein: 377-515
Range on HMM: 13-138/178.0
HNDQAIPGIFSTWITNDILALARPTqrgvdeFGLLDKLVESRVRVLINLEDHGEHANCGqgnlpggfsYDLDAFAARGVAVHLFGWADYGVPS-MQTALT
 . .....|  ..|...... . |.         |. | |  .....|| .  |.  ..         .|  ..   |. .. ... |.|||. ..  | 
eglersdyinaseilpglylgslpp......addlellkelgithivnlteelelgflk.........cdpywpeeagiqylhipipDhgvpdllehfle

MVKVAAQAL-DLQVAVAVHCHAGLGRTGMLIACILVYVLKL
.|.   .|| . . .|.|||.||.||.|.|.|. |...|.|
fvefieealdekggpvlVHCsaGvgRsgtlvaaylmkklgl
0051429 (Phosphotyrosine protein) phosphatases II 378-513 8.3e-13 44.1 In-house 8-175 (272) alignment 
Range on Protein: 378-513
Range on HMM: 8-175/272.0
NDQAIPGIFSTWITNDILALARPTQRGVDEFGLLdklVESRVRVLINLEDHGEHANCGQGNLPGGFSYDLDAFAARGVAVH-------------------
|   ..| ... . . ... ..|..  ...|  |    | .... ..| .  |.. ..   .. |. |    .  ...  .                   
Nardvggygrvvkpgrlyrsggplpltaadfwrl...kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyi

----------------------LFGWADYGVPSmQTALTMVKVAAQaldlQVAVAVHCHAGLGRTGMLIACILVYvL
                        .| |.|||. .. |..... ..    . .| |||.|| .|||...|..|.. |
lrellltlllsagearevmhlhytdwpdhgvpq.eallellellld....ggpvlvHCsaGkdRTGtvvalllll.l
0041856 (Phosphotyrosine protein) phosphatases II 380-522 1.4e-17 59.3 In-house 12-139 (182) alignment 
Range on Protein: 380-522
Range on HMM: 12-139/182.0
QAIPGIFSTWITNDILALARPTQRGVDE--------FGLLDKLVESRVRVLINLEdhgehancgqgnlpgGFSYDLDAFAARGVAVHLFGWADYGVPSMQ
   .......|.. ... ..|..| .             |. | | ......||                .. |. . .   |. .. ..| |.|||...
pydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt...............eelywpellerlgiqylylpwpDhgvpdld

TALTMVKVAAQaldLQVAVAVHCHAGLGRTGMLIACILVYVLklvypRTCV
..| ... . .    . .|.|||.||.||||.|.|. |...|     .  .
elldfieevle...eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsl
0046846 (Phosphotyrosine protein) phosphatases II 382-512 8.8e-21 69.9 In-house 7-134 (176) alignment 
Range on Protein: 382-512
Range on HMM: 7-134/176.0
IPGIFSTWITNDILALARPTQRGVD----EFGLLDKLVESRVRVLINLEDHGEHANCGqgnlpggFSYDLDAFAARGVAVHLFGWADYGVPSMQTALTMV
... ....|...... .||     .        |. | | ......|| .. |.. ..       . .. . . . |. .. ..| |.|||...  |...
gldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlk.......cpnywpeleklgiqylhlpwpDhgvpdlelllell

KVAAQALDLQVAVAVHCHAGLGRTGMLIACILVYV
.   .||.    |.|||.||.||||.|.|. |.. 
efirealkeggpvlVHCsaGigRtgtlvaayllel
0039614 (Phosphotyrosine protein) phosphatases II 385-529 1.9e-15 52.5 In-house 83-264 (297) alignment 
Range on Protein: 385-529
Range on HMM: 83-264/297.0
IFSTWI-----------TNDILALARPTQRGVDEFglLDKLVESRVRVLINLEDHGEHAN-CGQGNLPGGFSYD------LDAFAARGVA----------
  |..|           |....|   |..  |. |  .  . | .|.|...| .  |. . | |   . |  |.      |. .   |.           
ldsdYinAsyvdgydlltrkfIatqgPlpetvedF..wrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnng

-------VHLFGWADYGVP-SMQTALTMVKVAAQALD---LQVAVAVHCHAGLGRTGMLIACILVYVLKLVYPRTCVEGCVEHF
       .. .|| |.||| |... | ... . .||     .  |.|||.||.||||..||. |.. .   . . .|. .|...
esrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkel
0038934 (Phosphotyrosine protein) phosphatases II 386-514 1.4e-18 62.6 In-house 12-142 (194) alignment 
Range on Protein: 386-514
Range on HMM: 12-142/194.0
FSTWITNDILALARPTQRGVDEFglLDKLVESRVRVLINLEDHGEHANCGQGNLP-GGFSYDLDAFAARGVAVHLFGWADYG-VPSMQTALTMVKVAAQA
....||....|...|..  .|..  .. |.   .. |... ..  . ..   .|   .. || . | ..|. .. . . |.| |||... |. .... . 
vgdiitgrfiafkvPlsgsldky..ieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdef

LDL--QVAVAVHCHAGLGRTGMLIACILVYVLK
|.   . .|||||.|||||||.|.|. |.|.|.
lnedpggvvaVHCkaGlgRtGtlvaaYLiyrlg
0037934 (Phosphotyrosine protein) phosphatases II 387-514 5.4e-15 51.1 In-house 39-205 (243) alignment 
Range on Protein: 387-514
Range on HMM: 39-205/243.0
STWITNDILALARPTQRGVDE--FGLLDKLVESRVRVLINLEDHGEHANCGQGNLPG-G--------------------------FSYDLDAFAARGVAV
 ...|. . |   |..  |..     .. | | ...|...| .  |.  ..   .   .                            .||| .   .. .
liyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihy

HLFGWADYGVPS-MQTALTMVKVAAQ---------ALDLQVAVAVHCHAGLGRTGMLIACILVYVLK
| ..| |.|||. ..  | ... . .         ||| .  |.|||.||.||||.|||. |.. | 
hylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll
0040439 (Phosphotyrosine protein) phosphatases II 387-529 1.3e-13 46.7 In-house 49-221 (249) alignment 
Range on Protein: 387-529
Range on HMM: 49-221/249.0
STWITNDILALARPTQRGVDEFglLDKLVESRVRVLINLEDHGEH--ANCGQGNLPGGFS----------------------------YDLDAFAARGva
 ..|.....|   |..  |. |  .. | | ...|...| .  |.   .| |   .||.                             || . .  ..  
gyyikrrfiatqgPlpetvedf..wrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlh..

VHLFGWADYGVP-SMQTALTMVKVAAQALD---LQVAVAVHCHAGLGRTGMLIACILVYVLKLVYPRTCVEGCVEHF
.. ..| |.||| |....| ... . .||.    .  |.|||.||.||||..||. |.. .   . . ..| .|...
iqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkll
0036282 (Phosphotyrosine protein) phosphatases II 388-515 8.2e-19 63.4 In-house 13-132 (174) alignment 
Range on Protein: 388-515
Range on HMM: 13-132/174.0
TWITNDILALARPTQrgvdefgLLDKLVESRVRVLINLEDHGEHANCGQGNLPGGFSYDldaFAARGVAVHLFGWADYGVPSMQTALTMVKVAAQALDL-
..||. ..| . |..        .. | | .......| .  |  ...  |.   ...|   .   |. .. ..| |.|||.... |..|| . .||   
syitprliagqgpla.......fwemlkelgittvvmlleekelglykcinywpelred...lerlgiqylylpwpDhgvpdlsillefvkfveealsed

-QVAVAVHCHAGLGRTGMLIACILVYVLKL
 .  |.|||.||.||||.|.|. |.....|
pggpvlVHCsaGvgRtGtlvaaylmlrgll
0043147 (Phosphotyrosine protein) phosphatases II 388-514 1.2e-18 62.9 In-house 16-126 (172) alignment 
Range on Protein: 388-514
Range on HMM: 16-126/172.0
TWITNDILALARPTQRGVDEFglLDKLVESRVRVLINLEDHgehancgqgnlpggfSYDLDAFAARGVAVHLFGWADYGVPSMQTALTMVKVAAQ--ALD
..|.....|   |... ...|  .. | |  .....|| ..                || . .   |. .. ..| |.|||...  | ...   .  ||.
yyipdrfiatqgplrntladf..wrmlkelgithivnltel...............lydpellerlgiqylylpwpDhgvpllellleflefidellals

LQVAVAVHCHAGLGRTGMLIACILVYvLK
 . .|.|||.||.||||.|.|. |.. |.
pggpvlVHCsaGvgRtgtlvaaylml.lg
0051082 (Phosphotyrosine protein) phosphatases II 388-533 3.5e-14 48.1 In-house 9-132 (151) alignment 
Range on Protein: 388-533
Range on HMM: 9-132/151.0
TWITNDILALARPTQrgvdefGLLDKLVESRVRVLINLEDHGEHAncgqgnlpggfsYDLDAFAARGVAVHLFGWADYGVPSMQTA-LTMVKVAAQALDL
...|. ... . |..        |. | |  ... .|| .  |..            |. . . . |. |. . . |  .|....   .....  ..|| 
syvtgglyrsggpla......dflellkelgiktivnlrseeerg............ycpeylpelgievlhipildwpdpglplsfdavleflellldk

-QVAVAVHCHAGLGRTGMLIACILVYvLKlvyprTCVEGCVEHFAHTA
 .  |.|||.||.||||.|.|..|.. |.      ..| ..|..  . 
kngpvlvHCsaGkgRTGtlvalylml.lg.....vsleealeeyrlkr
0042113 (Phosphotyrosine protein) phosphatases II 389-529 2.2e-15 52.2 In-house 49-218 (245) alignment 
Range on Protein: 389-529
Range on HMM: 49-218/245.0
WITNDILALARPTQRGVDEFglLDKLVESRVRVLINLEDHGEHANC--GQGNLPGGF--------------------------SYDLDAFAARGVAVHLF
.||. ..| . |..  |. |  .  | | .......| .  |.  .   |   .|..                          ... | .   .. .| .
ritpkfiatqgPlpetvedf..wrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhyl

GWADYGVPS-MQTALTMVKVAAQALD--LQVAVAVHCHAGLGRTGMLIACILVYVLKLVYPRTCVEGCVEHF
.| |.|||. ... | ... . .||    .  |.|||.||.||||..||. |.. .   . . ..| .|...
pwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkel
0043336 (Phosphotyrosine protein) phosphatases II 389-529 3.8e-14 48.3 In-house 85-252 (278) alignment 
Range on Protein: 389-529
Range on HMM: 85-252/278.0
WITNDILALARPTQRGVDEFglLDKLVESRVRVLINLEDHGEHANCG---------------------QGNLPGGFSYD------LDAFAARGVAVHLFG
.......|   |..  |. |     . | .|.....| .  |. ...                     .  |..   ..       | .   .. .| .|
nvprkfiatqgPlpetvedF..wrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylg

WADYGVP-SMQTALTMVKVAAQALD-LQVAVAVHCHAGLGRTGMLIACILVYVLKLVYPRTCVEGCVEHF
| |.||| |... | ..|.. .||.  . .|.|||.||.||||..||. |.. .   . . ..| .|...
wpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkel
0045450 (Phosphotyrosine protein) phosphatases II 390-516 1.7e-13 46.5 In-house 105-263 (307) alignment 
Range on Protein: 390-516
Range on HMM: 105-263/307.0
ITNDILALARPTQRGVDEFglLDKLVESRVRVLINLEDHGEHAN--CGQGNLPGGFS----------------------------YDLDAFAARGVAVHL
... ..|   |..  |..|  .  | | .|.|...| .  |...  | |     | .                            .| . .  .    | 
lkrkfIatqgPlpetvedF..wrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhy

FGWADYGVP-SMQTALTMVKVAAQALD---LQVAVAVHCHAGLGRTGMLIACILVYVLKLV
 || |.||| |....| ... . .||.    .  |.|||.||.||||..||. |....   
tgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlek
0048076 (Phosphotyrosine protein) phosphatases II 413-514 8.1e-15 50.2 In-house 24-108 (145) alignment 
Range on Protein: 413-514
Range on HMM: 24-108/145.0
KLVESRVRVLINLedhgehancgqgnlpggfSYDLDAFAARGVAVHLFGWADYGVPSM-QTALTMVKVAAQALDLQVAVAVHCHAGLGRTGMLIACILVY
 | .  .. ..||                  ...|. . . |. .. ..| |.|||.. .. |....   .||.    |.|||.||.||||.|.|. |..
llkdlgittvlnl..................tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylml

VLK
 |.
llg
0045098 (Phosphotyrosine protein) phosphatases II 414-514 2.9e-14 48.6 In-house 84-233 (278) alignment 
Range on Protein: 414-514
Range on HMM: 84-233/278.0
LVESRVRVLINLEDHGEHA--NCGQGNLPGG-----------------------------FSYDLDAFAARGVAVHLF-GWADYGVPSMQ---TALTMVK
| | ...|...| .  | .   | |   .||                             ...    .  ||| .. . .| |.||||.      | ...
lwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflelle

VAAQALD--------------LQVAVAVHCHAGLGRTGMLIACILVYVLK
   .||.               .  |.|||.||.||||.|.|. |.. | 
firealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell
subfamily_PTEN_pd Subfamily PTEN 425-516 5.8e-10 34.4 In-house 53-143 (184) alignment 
Range on Protein: 425-516
Range on HMM: 53-143/184.0
LEDHGEHANCGQGNLPGGFSYDLDAFaarGVAVHLFGWADYGVPSMQTALTMVKVAAQALDL--QVAVAVHCHAGLGRTGMLIACILVYVLKLV
. ..  . .    || .. .|| . |      |. ..  |   |...   ..|. . . |.   .  |.|||.|| ||||.||.. |.. |.| 
flekkhkdhykiynlrserkydskkf...dgrvavypfdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllksllle
0049772 (Phosphotyrosine protein) phosphatases II 429-514 4.4e-14 48.4 In-house 167-240 (314) alignment 
Range on Protein: 429-514
Range on HMM: 167-240/314.0
GehancgqgnlpgGFSYDLDAFAARGVAVHLFGWADYGVPSMQTALTMVKVAAQAlDLQVAVAVHCHAGLGRTG-MLIACILVYVLK
             .  || . |  .|. .. . . |...|. .  . ....  .| | . .|.|||.|| |||| ...|..|.. |.
k............eelydpelferlgikylripvpDgsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllg
0048179 (Phosphotyrosine protein) phosphatases II 437-514 1e-13 46.7 In-house 48-110 (144) alignment 
Range on Protein: 437-514
Range on HMM: 48-110/144.0
GnlpggfsydldafaarGVAVHLFGWADYGVPSM-QTALTMVKVAAQALDLQVAVAVHCHAGLGRTGMLIACILVYVLK
                 |. .. ..| |.|||.. .  |....   .||.    |.|||.||.||||.|.|. |...|.
e................giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmkklg
subfamily_VSP_pd Subfamily VSP 441-514 9.4e-06 19.7 In-house 83-155 (212) alignment 
Range on Protein: 441-514
Range on HMM: 83-155/212.0
GGFSYDLDAFAARGVAVHLfgwADYGVPSMQTALTMVKVAAQAL--DLQVAVAVHCHAGLGRTGMLIACILVYVLK
   .||   |  | . ...    |. ||...  |.. | . . |  ||.  .|.||  | |||| .. ..|..   
seraydekyfnnrvkrili...ddhnvpkleellvftkevkewlekdlknvlaihckGGkgrtGtivcalllasei
0049260 (Phosphotyrosine protein) phosphatases II 444-513 5.9e-14 47.5 In-house 44-114 (152) alignment 
Range on Protein: 444-513
Range on HMM: 44-114/152.0
SYDLDAFAARGVAVHLFGWADYGVPSMQTALTMVKVAAQA--LDLQVAVAVHCHAGLGRTGMLIACILVYvL
...   . ...  .. . | |.|||..   | ..  . .   || .  |.|||.||.||||.|.|. |.. |
lelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.l
subfamily_PRL_pd Subfamily PRL 444-510 1.2e-07 25.9 In-house 45-113 (151) alignment 
Range on Protein: 444-510
Range on HMM: 45-113/151.0
SYDLDAFAARGVAVHLFGWADYGVPSMQTALTMVKVAAQAL--DLQVAVAVHCHAGLGRTGMLIACILV
.|| ... ..|. |. . ..| .||. .     ...  ..   . . .||||| |||||. .|.|  |.
tydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalali
subfamily_Tensin_pd Subfamily Tensin 445-511 8e-06 18.5 In-house 63-128 (189) alignment 
Range on Protein: 445-511
Range on HMM: 63-128/189.0
YDLDAFAArgvAVHLFGWADYGVPSMQTALTMVKVAAQAL--DLQVAVAVHCHAGLGRTGMLIACILVY
||.. .      |  ||| |   ||..   ...|   . |  |.|  |.|||. | ||.|..... . |
ydisklnk...kvldfGWPdllaPsleklcsicksldsWlkadpqnvvvvhckGgkgrigvvvsaymky
subfamily_CDKN3_pd Subfamily CDKN3 447-521 4.5e-10 33.4 In-house 92-166 (202) alignment 
Range on Protein: 447-521
Range on HMM: 92-166/202.0
LDAFAARGVAVHLFGWADYGVPSMQTALTMVKVAAQALDLQVAVAVHCHAGLGRTGMLIACILVYVLKLVYPRTC
|| .   |..|| .  || .||.. . | ...    .|. .    |||. ||||. ..|||.|.|.   . |.  
ldlyqqaglivhhypiadglvpdiasclkileelrinlkayrktlvhcygglgrsslviaclllylddtiepkda
CDKN3 Cyclin-dependent kinase inhibitor 3 (CDKN3) 447-519 2.2e-08 25.4 Pfam-A 93-165 (168) alignment 
Range on Protein: 447-519
Range on HMM: 93-165/168.0
LDAFAARGVAVHLFGWADYGVPSMQTALTMVKVAAQALDLQVAVAVHCHAGLGRTGMLIACILVYVLKLVYPR
|| .   |.  |    || | | . ..| ...  | .|  .    .||. ||||. .. ||.|.|.   . |.
ldlyqqygivthhhpiadggtpdiascleimeelatclknyrktlihcygglgrsclvaaclllylsdsispe
CDKN3 Cyclin-dependent kinase inhibitor 3 (CDKN3) 447-519 2.2e-08 25.4 In-house 93-165 (168) alignment 
Range on Protein: 447-519
Range on HMM: 93-165/168.0
LDAFAARGVAVHLFGWADYGVPSMQTALTMVKVAAQALDLQVAVAVHCHAGLGRTGMLIACILVYVLKLVYPR
|| .   |.  |    || | | . ..| ...  | .|  .    .||. ||||. .. ||.|.|.   . |.
ldlyqqygivthhhpiadggtpdiascleimeelatclknyrktlihcygglgrsclvaaclllylsdsispe
subfamily_PTPMT1_pd Subfamily PTPMT1 450-515 5e-06 21.1 In-house 69-135 (171) alignment 
Range on Protein: 450-515
Range on HMM: 69-135/171.0
FAARGVAVHLFGWADYG-VPSMQTALTMVKVAAQALDLQVAVAVHCHAGLGRTGMLIACILVYVLKL
.   ||    .   |.   |.... .  |..  .  ...  | |||.|| ||.. |.|| |..  ||
wkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkekl
subfamily_DSP23_pd Subfamily DSP23 451-515 1.6e-09 32.5 In-house 48-112 (148) alignment 
Range on Protein: 451-515
Range on HMM: 48-112/148.0
AARGVAVHLFGWADYGVPSMQTALTMVKVAAQALDLQVAVAVHCHAGLGRTGMLIACILVYVLKL
|. ..... ..  ||  |...    .|.|  .| . . ||.|||  | |||| ..|| ||   ||
atpnltlvrlriddyhppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerkl
0048567 (Phosphotyrosine protein) phosphatases II 456-515 2.4e-07 25.3 In-house 39-105 (157) alignment 
Range on Protein: 456-515
Range on HMM: 39-105/157.0
AVHLFGWADYGVPSMQTALTMVKVAAQALD----LQVAVAVHCHAGL---GRTGMLIACILVYVLKL
 |..  ..|.| ... .    .... . |.       |.||||.|||   |||..||.| |...|..
lvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgf
subfamily_PTPN23_pd Subfamily PTPN23 456-512 4.4e-06 20.7 In-house 175-235 (288) alignment 
Range on Protein: 456-512
Range on HMM: 175-235/288.0
AVHLFGWADYGVPS-MQTALTMVKVAAQ-----ALDLQVAVAVHCHAGLGRTGMLiaCILVYV
 ..|. |...|||.  .| | ..... .        ... . ||| || ||||..  .... .
hlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvf..alvyaa
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 456-507 8.8e-06 20.2 In-house 189-243 (298) alignment 
Range on Protein: 456-507
Range on HMM: 189-243/298.0
AVHLFGWADYGVPSMQTALTM--VKVAAQALDLQ-VAVAVHCHAGLGRTGMLIAC
 .| . |.| |||...|..     || |.  .   ..| |.| || ||.|  || 
qlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiai
0040438 (Phosphotyrosine protein) phosphatases II 457-529 5.7e-12 41.0 In-house 177-251 (317) alignment 
Range on Protein: 457-529
Range on HMM: 177-251/317.0
VHLFGWADYGVP-SMQTALTMVKVAAQALDL-QVAVAVHCHAGLGRTGMLIACILVYVLKLVYPRTCVEGCVEHF
 |  || |.||| |... | ... . .||.  .  |.|||.||.||||..||. |.. .   . . .|| .|...
fhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkel
0047943 (Phosphotyrosine protein) phosphatases II 457-525 1.3e-11 39.9 In-house 171-243 (273) alignment 
Range on Protein: 457-525
Range on HMM: 171-243/273.0
VHLFGWADYGVP-SMQTALTMVKVAAQALD---LQVAVAVHCHAGLGRTGMLIACILVYVLKLVYPRTCVEGC
.| .|| |.||| |..  |...... .||     .  |.|||.||.||||..||. |.. .   . . .|. .
fhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvlea
0046845 (Phosphotyrosine protein) phosphatases II 457-513 4.6e-11 38.1 In-house 170-230 (284) alignment 
Range on Protein: 457-513
Range on HMM: 170-230/284.0
VHLFGWADYGVP-SMQTALTMVKVAAQALDL---QVAVAVHCHAGLGRTGMLIACILVYVL
 | ..| |.||| |..  |.... . ..|.    .  ..|||.||.||||..||. |.. .
fhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleq
0051299 (Phosphotyrosine protein) phosphatases II 457-517 1.2e-10 36.9 In-house 187-249 (288) alignment 
Range on Protein: 457-517
Range on HMM: 187-249/288.0
VHLFGWADYGVPS-MQTALTMVKVAAQA-LDLQVAVAVHCHAGLGRTGMLIACILVYVLKLVY
 | ..| |.|||. ..  |.... . .|  . .  |.|||.||.||||..||. |.. . .  
fhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqleke
0036941 (Phosphotyrosine protein) phosphatases II 457-517 5.7e-10 34.4 In-house 173-240 (297) alignment 
Range on Protein: 457-517
Range on HMM: 173-240/297.0
VHLFGWADYGVPS-MQTALTMVKVAAQALD---LQVAVAVHCHAGLGRTGMLIACILVYVLKL---VY
 | .|| |.|||. ... | ... . ..|.    .  | |||.||.||.|..||. |.. .      .
fhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklke
PTPc_DSPc_SM00012 457-527 7.2e-09 31.2 In-house 5-80 (105) alignment 
Range on Protein: 457-527
Range on HMM: 5-80/105.0
VHLFGWADYGVPS-MQTALTMVKVAAQALDLQ---VAVAVHCHAGLGRTGMLIACILVYVLKLVY-PRTCVEGCVE
.|  || | |||. ..  |....   .    .     | |||.|| ||||...|  ...        . ... .|.
yhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivk
subfamily_PTPRB_pd Subfamily PTPRB 457-507 5e-08 27.3 In-house 184-238 (293) alignment 
Range on Protein: 457-507
Range on HMM: 184-238/293.0
VHLFGWADYGVPSM-QTALTMVKVAAQAL---DLQVAVAVHCHAGLGRTGMLIAC
 |   |.|.|||.  .| |..|.   .|.     .  . ||| ||.|||| .|| 
yhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfial
DSPc_SM00195 457-509 5e-08 28.0 In-house 163-217 (263) alignment 
Range on Protein: 457-509
Range on HMM: 163-217/263.0
VHLFGWADYGVP-SMQTALTMVKVAAQALD-LQVAVAVHCHAGLGRTGMLIACIL
..  .| | ||| |..  | ..... .  .  .. . |||.||.||||....  .
yqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidi
PTPc_SM00194 457-509 5e-08 28.0 In-house 163-217 (263) alignment 
Range on Protein: 457-509
Range on HMM: 163-217/263.0
VHLFGWADYGVP-SMQTALTMVKVAAQALD-LQVAVAVHCHAGLGRTGMLIACIL
..  .| | ||| |..  | ..... .  .  .. . |||.||.||||....  .
yqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidi
subfamily_PTPRK_pd Subfamily PTPRK 457-510 1.9e-07 25.2 In-house 178-233 (314) alignment 
Range on Protein: 457-510
Range on HMM: 178-233/314.0
VHLFGWADYGVPSMQTALTM--VKVAAQALDLQVAVAVHCHAGLGRTGMLIACILV
..  ||.|..||  .|.|     .| ..  . .  . ||| || ||||. ||.  |
fqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidiv
subfamily_PTPRA_pd Subfamily PTPRA 457-507 2e-07 25.2 In-house 196-248 (330) alignment 
Range on Protein: 457-507
Range on HMM: 196-248/330.0
VHLFGWADYGVPSMQTALTMV--KVAAQALDLQVAVAVHCHAGLGRTGMLIAC
.|. .| | |||.    .  .  || ..      .. ||| || |||| .|. 
fhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivl
Y_phosphatase Protein-tyrosine phosphatase 457-508 5e-07 24.7 Pfam-A 138-191 (235) alignment 
Range on Protein: 457-508
Range on HMM: 138-191/235.0
VHLFGWADYGVPS-MQTALTMVKVAAQAL-DLQVAVAVHCHAGLGRTGMLIACI
.|. .| |.|||.  .  | ...   .   . .  | ||| || ||||...|  
lhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvald
Y_phosphatase Protein-tyrosine phosphatase 457-508 5e-07 24.7 In-house 138-191 (235) alignment 
Range on Protein: 457-508
Range on HMM: 138-191/235.0
VHLFGWADYGVPS-MQTALTMVKVAAQAL-DLQVAVAVHCHAGLGRTGMLIACI
.|. .| |.|||.  .  | ...   .   . .  | ||| || ||||...|  
lhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvald
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 457-513 9.3e-07 22.9 In-house 191-243 (305) alignment 
Range on Protein: 457-513
Range on HMM: 191-243/305.0
VHLFGWADYGVPSMQTAltMVKVAAQALDLQVAVAVHCHAGLGRTGMLIacILVYVL
 |   | | |||. ..|  .... ..|  ..  ..||| ||.|||| ..  .| |.|
yhwidwpdrgvpaadla..ilellekarpskgpivvhcsagigrtgsvv..mleyil
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 457-506 2.1e-06 22.1 In-house 183-235 (305) alignment 
Range on Protein: 457-506
Range on HMM: 183-235/305.0
VHLFGWADYGVPSMQTALT-MVKV--AAQALDLQVAVAVHCHAGLGRTGMLIA
 .|  | | ||| . |.|  ..|    .|  | .|.. ||| ||.||||. ||
yqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfia
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 457-507 5.8e-06 20.8 In-house 190-244 (319) alignment 
Range on Protein: 457-507
Range on HMM: 190-244/319.0
VHLFGWADYGVPSMQTALT-MVKV---AAQALDLQVAVAVHCHAGLGRTGMLIAC
 |. || |.|||   . |  .||      .  . .  . ||| || ||||. |. 
fhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivl
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 457-507 6.8e-06 20.8 In-house 154-208 (284) alignment 
Range on Protein: 457-507
Range on HMM: 154-208/284.0
VHLFGWADYGVPSMQTALT-MVKV---AAQALDLQVAVAVHCHAGLGRTGMLIAC
 |. || |.||| . . |  .||      .  . .  . ||| || ||||. |. 
fhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivl
0050432 (Phosphotyrosine protein) phosphatases II 458-513 3.1e-10 35.3 In-house 203-258 (308) alignment 
Range on Protein: 458-513
Range on HMM: 203-258/308.0
HLFGWADYGVPS-MQTALTMVKVAAQALdLQVAVAVHCHAGLGRTGMLIACILVYVL
|  .| |.|||. ..  |.... . . |  .  ..|||.||.|||| .||. |.. .
hytnWpdhgvPpspeilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleq
subfamily_PTPN13_pd Subfamily PTPN13 458-510 2.7e-08 28.4 In-house 172-225 (273) alignment 
Range on Protein: 458-510
Range on HMM: 172-225/273.0
HLFGWADYGVPSMQTA-LTMVKVAAQALDLQVAVAVHCHAGLGRTGMLIACILV
..  | |.||||  .  |..|.  ..  . .  ..||| ||.||.|.||.   |
nfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvv
subfamily_PTPN12_pd Subfamily PTPN12 458-509 1.3e-07 25.8 In-house 176-229 (290) alignment 
Range on Protein: 458-509
Range on HMM: 176-229/290.0
HLFGWADYGVPSMQT-ALTMVKVAAQAL-DLQVAVAVHCHAGLGRTGMLIACIL
|   | | |||| ..  | ... . .   . .. ..||| || |||| .||  .
hYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidy
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 458-507 3.2e-06 20.8 In-house 194-241 (302) alignment 
Range on Protein: 458-507
Range on HMM: 194-241/302.0
HLFGWADYGVPS-MQTALTMVKVAAQaldLQVAVAVHCHAGLGRTGMLIAC
.  .| |.| |   .||| ..|        . .| ||| ||.|||| |.| 
afsawpdhGapkeaytaldilkfces...ykknvlvhcsaGvGrtGtlvai
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 458-513 6.2e-06 20.1 In-house 194-245 (305) alignment 
Range on Protein: 458-513
Range on HMM: 194-245/305.0
HLFGWADYGVPSMQtaLTMVKVAAQALDLQVAVAVHCHAGLGRTGMLIACilVYVL
.   | | |||  .  || ... .     .| . ||| ||.|||| ..|    |.|
qwtewpdrgvppck..ltslellsairgskvpivvhcsagigrtgtivai..eyil
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 459-506 2.1e-06 22.1 In-house 177-227 (281) alignment 
Range on Protein: 459-506
Range on HMM: 177-227/281.0
LFGWADYGVPSMQTALTMVKVAA---QALDLQVAVAVHCHAGLGRTGMLIA
   | | |||.  ..|   . .    .  . .... .|| || ||||  ||
ytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyia
subfamily_PTPN3_pd Subfamily PTPN3 459-507 4.4e-06 20.8 In-house 178-228 (280) alignment 
Range on Protein: 459-507
Range on HMM: 178-228/280.0
LFGWADYGVPSMQTA-LTMVK-VAAQALDLQVAVAVHCHAGLGRTGMLIAC
   |.| |||. ..  |..|. | ..    .  | ||| ||.||||.||. 
ylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlill
MbtH MbtH-like protein 1033-1061 7e-06 11.9 Pfam-A 9-39 (54) alignment 
Range on Protein: 1033-1061
Range on HMM: 9-39/54.0
ERSRFY--KNDQEQVQHFPEGQEVPQGWRLV
|  .|.   ||.||    |. .|||.||| |
edgsflVlvNdeeqySlWpafaevPaGWrvv