Gene DSP19 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP19
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP010_AA protein Get Run
NvecP010_AA_103-242 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0049772 (Phosphotyrosine protein) phosphatases II 80-242 1.1e-30 102.9 In-house 118-272 (314) alignment
Range on Protein: 80-242
Range on HMM: 118-272/314.0
EGNSPIIVDT---------------------GERTYGFcedtkhdvtlakieeglflgSQDGAHCYEELQrnnithilnvatGVV---NVFAKD-FTYKN
. |. .|| .                      . . ..                    ..  |. .|.|.            ...   . | .  ..|..
dlnvrdivmsrdevladelsrLdaAlgKtpllildgng....................neptaadlellk............eelydpelferlgikylr

IELLDlPETDLVAQLPQMFQFINDGLQAGAVLVHCNAGVSRSP-AVVIAYLMHKRLLSLGQAFNVVREQRPcVKPNEGFWRQLCNYEQQ
| . | ....| ........||..  . |.|||||.||..|.. .||.||||... .|| .|.. ||..|| ..||.||..||..||..
ipvpD.gsaplledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefi

subfamily_DSP19_pd Subfamily DSP19 95-243 3.1e-71 232.6 In-house 1-150 (152) alignment
Range on Protein: 95-243
Range on HMM: 1-150/152.0
GFCEDTKHDVTLAKIEEGLFLGSQDGAHCYEELQRNNITHILNVATGVVNVFAKDFTYKNIELLDLPETDLVAQLPQMFQFINDGLQA-GAVLVHCNAGV
||.||.|.|......|. |.|||||.|...|.|....|||||||||||.|||.|||||..||.||||||||...|.....||...... |||||||||||
gfveDlkedlevgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGv

SRSPAVVIAYLMHKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQQK
|||..|||||||.|. ||| .|...|||.|||.||||||..||..||...
SRsasvviaylmkkeelsleealelvrearpcikPneGFikqLkeyeael

subfamily_DSP1_pd Subfamily DSP1 101-242 1.6e-41 136.1 In-house 14-155 (163) alignment
Range on Protein: 101-242
Range on HMM: 14-155/163.0
KHDVTLaKIEEGLFLGSQDGAHCYEELQRNNITHILNVATGVVNVFAKDFTYKNIELLDLPETDLVAQLPQMFQFINDGL-QAGAVLVHCNAGVSRSPAV
 .| .  || . |.|||.  |   | |....||.||||.. . ||| . |.||...| | |. |. . . .. .||..   . | ||.||.||.||| ..
lydPve.kildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstl

VIAYLMHKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQQ
..||||... .|| .||. |...|....|| || .|| |||..
claylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekk

subfamily_DSP8_pd Subfamily DSP8 101-242 1.9e-25 83.3 In-house 10-153 (159) alignment
Range on Protein: 101-242
Range on HMM: 10-153/159.0
KHDVTLAKIEEGLFLGSQDGAHCYEELQRNNITHILNVATGV-VNVFAKDFTYKNIELLDLPETDLVAQLPQMFQFINDGLQ-AGAVLVHCNAGVSRSPA
 .|| . .| . |.||||  .   | |....|...||. .      . |.  .  . . |  . .|.  ... ..||.   .  | ||||. || |||..
vadvgptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsat

VVIAYLMHKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQQ
|.|||.|..  .|| .|.. |.|.|| ..||  |  || .||..
vaiayimktlemsldeayrfvkekrptispnlnflgqLleyeke

subfamily_DSP10_pd Subfamily DSP10 102-242 1.6e-36 119.6 In-house 10-152 (159) alignment
Range on Protein: 102-242
Range on HMM: 10-152/159.0
HDVTLAKIEEGLFLGSQDGAHCYEELQRNNITHILNVATGVVNVFAK-DFTYKNIELLDLPETDLVAQLPQMFQFINDGLQAG-AVLVHCNAGVSRSPAV
. . ....   |||||. .|.  . |.| |||..|||.| | | |.. ...|| |.. |  . .|  .  . ..||..  . |  |||||.||.||| .|
etapasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatv

VIAYLMHKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQQ
||||||... ||| .|.. |.|.|| . || .|  || ..|..
viaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefeke

0045098 (Phosphotyrosine protein) phosphatases II 102-242 2.5e-30 101.2 In-house 18-270 (278) alignment
Range on Protein: 102-242
Range on HMM: 18-270/278.0
HDVTLAKIEEGLFLGSQD-----------------------------------------GAHCYEELQRNNITHILNVA---------------------
.     .|...|.||..|                                          |. .. |. ..||.|....                     
llgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggslt

-------------------------------TGVVNVFAKDFTYKNIELLDLPETDLVAQLPQMFQFINDGL---------------QAGAVLVHCNAGV
                               ..  . . . . |....  . |........ ....||.. |               . | |||||.|||
ygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGv

SRSPAVVIAYLMHKR---LLSLGQAFNVVREQRPC-VKPNEGFWRQLCNYEQQ
.|. ..|.|||| ..    ..| .|.. .|.|||. . .|....|.|. ....
gRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyeflle

0041856 (Phosphotyrosine protein) phosphatases II 102-241 5.1e-30 99.8 In-house 15-170 (182) alignment
Range on Protein: 102-241
Range on HMM: 15-170/182.0
HDVTLAKIEEGLFLGSQDG--------------AHCYEELQRNNITHILNVAtgVVNVFAKDF-----TYKNIELLDLPETDlvaqLPQMFQFINDGLQ-
|.  | .| ..|.|||. .              |. .. |....||.|.|..   .. .....     .|...   | . .|    |.....||.. |. 
hsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd....ldelldfieevlee

AGAVLVHCNAGVSRSPAVVIAYLMHKRLLSLGQAFNVVREQRP--CVKPNEGFWRQLCNYEQ
 |.|||||.|||.|....|.||||.|. .|| .|.. ||..||  .. || .|..||. .| 
ggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallel

PTEN_1 102-242 1.7e-29 98.0 In-house 32-190 (196) alignment
Range on Protein: 102-242
Range on HMM: 32-190/196.0
HDVTLA-----KIEEGLFLGSQDGAHC-YEELQRNNITHILNVATGVVN---------VFAKDFTYKNIELLDLPETDLVAQLPQMFQFINDGLQ---AG
.... .     .|.|||..||.. . .  ..|. ..||...|.. .  .          |.....|....  | .  .|   .    .||.  |.    .
mgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngn

AVLVHCNAGVSRSPAVVIAYLMHKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQQ
.||||| ||..||  ||.||||.|. |.  .|.  |||.||.. || .....| .|...
vVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfae

subfamily_DSP6_pd Subfamily DSP6 103-242 3.1e-37 121.5 In-house 11-153 (158) alignment
Range on Protein: 103-242
Range on HMM: 11-153/158.0
DVTLAKIEEGLFLGSQDGAHCYEELQRNNITHILNVATGVVNVFAK--DFTYKNIELLDLPETDLVAQLPQMFQFINDGLQAG-AVLVHCNAGVSRSPAV
. ....| . |.|||.. |.  | |.. .| ..|||.. . |.|..  ...|..| . |  ...| . .|. ..||... ..  .||||| ||.||| .|
aefpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtv

VIAYLMHKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQQ
..||||.|. ||| .|...|..... . ||  |  || ..|..
tlaylmkklalslndaydlvkkrksnisPnfnfmgqlldfers

0046846 (Phosphotyrosine protein) phosphatases II 103-242 6.7e-28 93.0 In-house 9-171 (176) alignment
Range on Protein: 103-242
Range on HMM: 9-171/176.0
DVTLAKIEEGLFLGSQD----------GAHCYEELQRNNITHILNVATGV-----------VNVFAKDFTYKNIELLDLPETDLvAQLPQMFQFINDGLQ
|  |  | ..|.|||             |.  |.|....||...|. . |             . . ...|...   |    || ..|.....||.. |.
dldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealk

AG-AVLVHCNAGVSRSPAVVIAYLMHK-RLLSLGQAFNVVREQRP-CVKPNEGFWRQLCNYEQQ
.|  ||||| ||..|....|.|||... . ||. .|.  |||||| .. ......|.|  .|..
eggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefell

0037934 (Phosphotyrosine protein) phosphatases II 104-242 3.4e-24 81.2 In-house 37-240 (243) alignment
Range on Protein: 104-242
Range on HMM: 37-240/243.0
VTLAKIEEGLFLGSQ--------DGAHCYEELQRNNITHILNVATGV----------------------------------------VNVFAKDFTYKNI
  | .. ..|.....        | |. .. |....||.|... . |                                        .|. ..|.|. .|
anliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvi

ELLDLPETD----L-VAQLPQMFQFIND----------GLQAGAVLVHCNAGVSRSPAVVIAYLMHKR-LLSLGQAFNVVREQRPC-VKPNEGFWRQLCN
 .. ||  |      ...| ........            . | ||||| |||.|. ....||||...  ..| .|.. .|||||. . ......|.|  
hyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflye

YEQQ
....
alle

0042113 (Phosphotyrosine protein) phosphatases II 104-241 3.7e-24 80.9 In-house 45-240 (245) alignment
Range on Protein: 104-241
Range on HMM: 45-240/245.0
VTLAKIEEGLFLGSQDGAHCYE----ELQRNNITHILNVATGV----------------------------------------------VNVFAKDFTYK
|.. .| ........  .. .|     |....||.|... . .                                               .   ....| 
vdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyh

NIELLDLPETDLVAQLPQMFQFINDGLQ---AGAVLVHCNAGVSRSPAVVIAYLM-----HKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQ
 .   | ...||...| ....|... |.    | |||||.|||.|. ....||||     . . .|| .|.  .|.|||.. ......|.|  ...
ylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall

subfamily_DSP14_pd Subfamily DSP14 105-242 3.2e-39 128.4 In-house 6-143 (157) alignment
Range on Protein: 105-242
Range on HMM: 6-143/157.0
TLAKIEEGLFLGsQDGAHCYEELQRNNITHILNVATGVVNVFAKDFTYKNIELLDLPETDLVAQLPQMFQFINDG-LQAGAVLVHCNAGVSRSPAVVIAY
.|..|.. |||.   .|   |.|....||.|.||.. ..|  .||. . .. . | ||..|.. . .. . |..   ..|..|||| |||||| ....||
alsqitpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclay

LMHKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQQ
||. . ||| .|...|...|| ..|| |||.|| .||..
lmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkk

0036282 (Phosphotyrosine protein) phosphatases II 105-241 2.1e-27 91.3 In-house 11-167 (174) alignment
Range on Protein: 105-241
Range on HMM: 11-167/174.0
TLAKIEEGLFLGSQDGAhCYEELQRNNITHILNVATGVVNV---------------FAKDFTYKNIELLDLPETDLVAqLPQMFQFINDGLQA---GAVL
 |  | ..|..|.   |  .|.|....||..... . . .                   ...|. .   |  . ||   | ....|... |.    | ||
dlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvl

VHCNAGVSRSPAVVIAYLMHKRLL-SLGQAFNVVREQR---PCVKPNEGFWRQLCNYEQ
|||.|||.|....|.||||...|| || .|...|||.|   |.. ......|.|  .|.
VHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfek

0044763 (Phosphotyrosine protein) phosphatases II 106-242 2.2e-39 130.2 In-house 23-169 (178) alignment
Range on Protein: 106-242
Range on HMM: 23-169/178.0
LAKIEEGLFLGSQDGAHCYEELQRNNITHILNVATGVVNVFAKD---------FTYKNIELLDLPETDLVAQLPQMFQFINDG--LQAGAVLVHCNAGVS
. .| .||.|||.  |. .| |....||||.|... . . | |.         ..|..| . | ...|| ........||..    . |.|||||.|||.
aseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvg

RSPAVVIAYLMHKRLLSLGQAFNVVREQRPcVKPNEGFWRQLCNYEQQ
||...|.||||.|. ||| .|.. |||.|| . ||.|..|||. .|..
RsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelr

subfamily_DSP15_pd Subfamily DSP15 106-243 1.3e-31 103.7 In-house 2-139 (151) alignment
Range on Protein: 106-243
Range on HMM: 2-139/151.0
LAKIEEGLFLGSQDGAHCYEELQRNNITHILNVATgVVNVFAKDFTYKNIELLDLPETDLVAQLPQMFQFINDG-LQAGAVLVHCNAGVSRSPAVVIAYL
. |. .||.||    ..  | |...||||||.|     . . ||..|| |.. | |...|   . .  .|| .  |. ..||||| ||||||  .|.|||
iskvlpglylgnfrdskdeelLkeknithilsvhd.nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYl

MHKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQQK
|    |.  .|..|....| . .|| || ||| .||..|
mtvtelnwrdalevikaaRsvanPnfGfkrqlkeyektk

subfamily_STYX_pd Subfamily STYX 106-241 2.5e-27 89.0 In-house 12-155 (166) alignment
Range on Protein: 106-241
Range on HMM: 12-155/166.0
LAKIEEGLFLGSQDGAH--CYEELQRNNITHILNV-----ATGVVNVFAKDFTYKNIELLDLPETDLVAQLPQMFQFINDGLQAG-AVLVHCNAGVSRSP
. .|  |||||    |     | |... ||||. .     |. .   | ..| |  ... | .  ...  ||.. .||.| || |  |||| |||.||| 
mqeilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsa

AVVIAYLMHKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQ
|.||||.|    |   .||  |.|.| |..||||| .|| .|| 
alviayimetyglkyreafayvqerrfcinpnegfvsqlkeyea

subfamily_Slingshot_pd Subfamily Slingshot 107-240 1.5e-40 132.3 In-house 20-154 (169) alignment
Range on Protein: 107-240
Range on HMM: 20-154/169.0
AKIEEGLFLGSQDGAHCYEELQRNNITHILNVATGVVNVFAKDFTYKNIELLDLPETDLVAQLPQMFQFINDGLQAG-AVLVHCNAGVSRSPAVVIAYLM
.|| . ..|||.  |  .|||..|....||||.  . | |...|.|.|| . | .||||...  . ..||.   ..|  |||||  ||||| ..|||| |
skifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayam

HKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYE
..  ||| .|.. |.|.| ..|||.||..|| .||
keyglsleealeyvkerrsvikPnkgflkqleeye

subfamily_DSP12_pd Subfamily DSP12 107-241 3.2e-39 128.8 In-house 3-141 (155) alignment
Range on Protein: 107-241
Range on HMM: 3-141/155.0
AKIEEGLFLGSQDGAHCYEELQRNNITHILNVATGVVNVF---AKDFTYKNIELLDLPETDLVAQLPQMFQFINDGL-QAGAVLVHCNAGVSRSPAVVIA
 .|..||.||.   .. .| |.  .|||.| |..  .. .   ..  ..|.|..|| ||.|..  |.....||...| . |||||||.|||||| ..|||
srilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviA

YLMHKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQ
|||.|  ||| .|...|.|..| ..||||| .||  .|.
YlmkkeklslekAlklvkekkpeiepNegFleQLklfek

0048076 (Phosphotyrosine protein) phosphatases II 107-242 1.1e-35 117.7 In-house 5-141 (145) alignment
Range on Protein: 107-242
Range on HMM: 5-141/145.0
AKIEEGLFLGSQDGAHCYEELQRNNITHILNVATGVVNVFAKDFTYKNIELLDLPETDLVAQLPQMFQFINDGLQAG-AVLVHCNAGVSRSPAVVIAYLM
..| .||.|||.  |. .|.|....||..||...   ........| .. . | .. || ..|.....||.. |..|  |||||.|||.|....|.||||
seilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylm

HKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQQ
... .|| .|.. ||.|||.. ||.|..|.|. .|..
lllgvsleealelvrsqrpgavpnpgqlrflyefele

0048179 (Phosphotyrosine protein) phosphatases II 107-241 5.9e-35 115.4 In-house 5-142 (144) alignment
Range on Protein: 107-241
Range on HMM: 5-142/144.0
AKIEEGLFLGSQDGAHCYEELQRNNITHILNVATGVVNVFAKDF--TYKNIELLDLPETDLVAQLPQMFQFINDGLQ-AGAVLVHCNAGVSRSPAVVIAY
..| .||.|||.  |. .|.|....||...|....  . | ...  .| .. . | .  || ..|.....||.. |.  | |||||.|||.|....|.||
seilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaay

LMHKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQ
||.|. ||| .|.. ||..||.. ||.|..|.|..||.
lmkklglsleealalvrsrrpgavpnpgqlrfLleyek

PTPc_motif_SM00404 108-241 1.3e-38 127.0 In-house 4-139 (140) alignment
Range on Protein: 108-241
Range on HMM: 4-139/140.0
KIEEGLFLGSQDGAHCYEELQRNNITHILNVATGVVN-VFAKDFTYKNIELLDLPETDLVAQLPQMFQFINDGLQAGA-VLVHCNAGVSRSPAVVIAYLM
.| ..|.|||.. |   . |. ..|||..||.. |..    ..|....|.| |  ...|...|... .||..  . |  ||||| |||||| ...|||||
rilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlm

HKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQ
..| ||| .|...|.|.||...||..|.|||..||.
ryrqlslaeayefvkerRpiispnlnfvrqLieyek

subfamily_LRR-DSP_pd Subfamily LRR-DSP 108-242 2.5e-36 119.1 In-house 122-257 (263) alignment
Range on Protein: 108-242
Range on HMM: 122-257/263.0
KIEEGLFLGSQDGAHCYEELQRNNITHILNVATGVVNVFAKDFTYKNI-ELLDLPETDLVAQLPQMFQFINDGLQAGAVLVHCNAGVSRSPAVVIAYLMH
.| ..||||..| |     |. ...||||   . .  .| | | |  | .. | .| |.   . ..  ||..| . | ||||| |||||| ..||.|||.
eiidklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkGGvlvhcraGvsrsstlvisylmk

KRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQQ
|. | . .|...| ..|| ..|| ||  ||  ||..
kqrlkfkealdlvikkrpriqPnpGfkdqlkkyekk

subfamily_DSP3_pd Subfamily DSP3 108-242 1.9e-31 102.9 In-house 13-156 (162) alignment
Range on Protein: 108-242
Range on HMM: 13-156/162.0
KIEEGLFLGSQDGAHCYEELQRNNITHILNVATGVV-NV-----FA--KDFTYKNIELLDLPETDLVAQLPQMFQFINDGLQA--GAVLVHCNAGVSRSP
 . ..|..| .. |.  ..|..  |||.|| | | . .|     |    ...|  .|. | ||.|| .   . ..||.. |.   | |||||..|||||.
evypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsa

AVVIAYLMHKRLLSLGQAFNVVREQRpCVKPNEGFWRQLCNYEQQ
..|.|||| .| ..| .| . ||..| .. ||||| .||......
tlvlayLmirrkmtlveairtvrkkR.eilPneGFlkqLaeldee

0051082 (Phosphotyrosine protein) phosphatases II 108-239 2.5e-23 77.7 In-house 10-149 (151) alignment
Range on Protein: 108-239
Range on HMM: 10-149/151.0
KIEEGLFLGSQDGAHCYEELQRNNITHILNVATGVVNVFAK------DFTYKNIELLDLPETDLVAQLPQMFQFINDGLQ--AGAVLVHCNAGVSRSPAV
 ...||.....  |. .|.|....|..|.|. . . . . .      ......| .|| |...|   .... .|..  |.   | |||||.||..|. ..
yvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtl

VIAYLMHKRlLSLGQAFNVVREQRP-CVKPNEGFWRQLCNY
|..|||. . .|| .|.. .|..|| .| ||..|. ||. .
valylmllg.vsleealeeyrlkrpgvvqpnqqflfqlfal

0051429 (Phosphotyrosine protein) phosphatases II 108-241 2.2e-20 68.9 In-house 18-222 (272) alignment
Range on Protein: 108-241
Range on HMM: 18-222/272.0
KIEEGLFLGSQD----GAHCYEELQRNNITHILNVATGVVNVFAK------DFTYKNIELLDLPETDLV-------------------------------
.. .|... |.      |. .. |....|..|... . .   . |      ...| .. .||  ...                                 
vvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsag

--------------------AQLPQMFQFINDglqAGAVLVHCNAGVSRSPAVVIAYLMHkRLLS--------------LGQAFNVVREQRPCVKPNEGF
                     .| .......|    |.|||||.||..|.  || ..|.  . .|              | .| . .|.|||.. ..|..
earevmhlhytdwpdhgvpqeallellellld...ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeq

WRQLCNYEQ
...|.....
ylflyeall

subfamily_PTPMT1_pd Subfamily PTPMT1 108-242 3.4e-17 57.4 In-house 22-167 (171) alignment
Range on Protein: 108-242
Range on HMM: 22-167/171.0
KIEEGLFLGSQDGAHCYEEL-QRNNITHILNVATGV----VNVFAKDFTYKNIELLDLPETDLV-----AQLPQMFQFINDGLQAG-AVLVHCNAGVSRS
.|.. ..||     .  .|| . .|.  ....        .    ....  ..| | |. .|       ..| .  .||..  . |  | |||.|| .||
riDdtvilGalPfrslikeLiekenvkavvslneeyelkalansteewkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRs

PAVVIAYLMHKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQQ
 ..|..|||.|. ||. .| ......|. .. ..  |..| .||..
atlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeek

subfamily_MKPLT_pd Subfamily MKPLT 109-241 8.1e-31 100.8 In-house 25-158 (164) alignment
Range on Protein: 109-241
Range on HMM: 25-158/164.0
IEEGLFLGSQDGAHCYEELQRNNITHILNVATGVVNVFAKDFTYKNIELLDLPETDLVAQLPQMFQFINDGLQA-GAVLVHCNAGVSRSPAVVIAYLMHK
.|. |.||  . |   . |.  .||||.||...  . |.| . | .... | ... | . | .. .|. | ... | |||||. |.||| .| .|.|.. 
ledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiks

RLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQ
.   |..|.. ..|.| .|.|| || .||...|.
kgwtlkeayeylkerrsivapnrGflkqlakfee

subfamily_MKPLV_pd Subfamily MKPLV 109-241 8.1e-31 100.8 In-house 25-158 (164) alignment
Range on Protein: 109-241
Range on HMM: 25-158/164.0
IEEGLFLGSQDGAHCYEELQRNNITHILNVATGVVNVFAKDFTYKNIELLDLPETDLVAQLPQMFQFINDGLQA-GAVLVHCNAGVSRSPAVVIAYLMHK
.|. |.||  . |   . |.  .||||.||...  . |.| . | .... | ... | . | .. .|. | ... | |||||. |.||| .| .|.|.. 
ledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiks

RLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQ
.   |..|.. ..|.| .|.|| || .||...|.
kgwtlkeayeylkerrsivapnrGflkqlakfee

0049260 (Phosphotyrosine protein) phosphatases II 109-241 4.7e-29 96.4 In-house 11-147 (152) alignment
Range on Protein: 109-241
Range on HMM: 11-147/152.0
IEEGLFLGSQDGAHCYEELQRNNITHILNVATGVVN---VFAKDFTYKNIELLDLPETDLVAQLPQMFQFIND--GLQAGAVLVHCNAGVSRSPAVVIAY
.  ....|... |. .. |....||.|... . . .    ... ..|...   | .  ||   |.....||.     . | ||||| |||.|....|.||
fiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaay

LMHkRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQ
||. . .|| .|.. |||.||.. ||.|..|.| ..|.
lml.lgvsleeavalvrekRpgavpnpgqlrflyefek

0043147 (Phosphotyrosine protein) phosphatases II 111-242 2.2e-30 101.0 In-house 24-159 (172) alignment
Range on Protein: 111-242
Range on HMM: 24-159/172.0
EGLFLGSQDGAHCYEELQRNNITHILNVATG---VVNVFAKDFTYKNIELLDLPETdLVAQLPQMFQFIND---GLQAGAVLVHCNAGVSRSPAVVIAYL
 ...... . |. .. |....||||.|. .      ...  ...|  .   | . . | ..|.....||..     . |.||||| |||.|....|.|||
atqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaayl

MHkRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQQ
|. . ||| .|.. |||.||.. .|....|.|. .|..
ml.lglsleeavalvrekRpgavqnpsqyrflyyfekl

subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 112-242 4.1e-38 124.1 In-house 9-151 (154) alignment
Range on Protein: 112-242
Range on HMM: 9-151/154.0
GLFLGSQDGAHCYEELQRNNITHILNVATGVVNVFAKD---------FTYKNIELLDLPETDLVAQLPQMFQFINDGL---QAGAVLVHCNAGVSRSPAV
 |...|.| |    .|| .||..||||..|. |.|...         . | |.|| | .. |.. .| . |.||.| .   . . ||||...||||| |.
flyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaal

VIAYLMHKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQQ
.|.|||.|. .|| .|. .... |. .|||.|| .||. .|..
lisylmdklkislslalellkdsryiikPnqGflkqleifeke

DSPc Dual specificity phosphatase, catalytic domain 113-242 1e-35 117.5 Pfam-A 1-133 (133) alignment
Range on Protein: 113-242
Range on HMM: 1-133/133.0
LFLGSQDGAHcYEELQRNNITHILNVATGVVN---VFAKDFTYKNIELLDLPETDLVAQLPQMFQFINDGLQAG-AVLVHCNAGVSRSPAVVIAYLMHKR
|.|||.  |   . |. ..||...||.. | |      ....| .| . |  ||.....|... .||..  | |  |||||.||.|||....||||| ..
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

LLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQQ
 ||| .|...|.|.|... ||.||.|||..||..
nlslneAyefvkerrskispnagflrqLleyerk

DSPc Dual specificity phosphatase, catalytic domain 113-242 1e-35 117.5 In-house 1-133 (133) alignment
Range on Protein: 113-242
Range on HMM: 1-133/133.0
LFLGSQDGAHcYEELQRNNITHILNVATGVVN---VFAKDFTYKNIELLDLPETDLVAQLPQMFQFINDGLQAG-AVLVHCNAGVSRSPAVVIAYLMHKR
|.|||.  |   . |. ..||...||.. | |      ....| .| . |  ||.....|... .||..  | |  |||||.||.|||....||||| ..
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

LLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQQ
 ||| .|...|.|.|... ||.||.|||..||..
nlslneAyefvkerrskispnagflrqLleyerk

subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 113-242 7.2e-28 91.0 In-house 15-146 (148) alignment
Range on Protein: 113-242
Range on HMM: 15-146/148.0
LFLGSQDGAHCYEELQRNNITHILNVATGVVNVFAKDFT-YKNIELLDLPETDLVAQLPQMFQFINDGLQAG-AVLVHCNAGVSRSPAVVIAYLMHKRLL
|||||.  |  .| |.  ..|.| | .    |....    | ...| | |. || |  ... .|..   ..|  ||||.. ||||| |.....|.. .  
LFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkrv

SLGQAFNVVREQRPCVKPNEGFWRQLCNYEQQ
|| .|...|...|. |.|| || .|| ..||.
slkealalvkskrryvdpnlgfLkqLaeleqa

subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 116-242 1.2e-16 54.1 In-house 9-140 (145) alignment
Range on Protein: 116-242
Range on HMM: 9-140/145.0
GSQDGAHCYEELQRNNITHILNVATGVV----NVFAKDFTYKNIELLDLPETDLVAQLPQMFQFINDGLQAGA-VLVHCNAGVSRSPAVVIAYLMHKRLL
||   |.    ||   |. |.|.|.| .    .. .....   |   ||   ||   . .. .||. | . || |.||| |||||| .| .|.||.   .
gsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnm

SLGQAFNVVREQRPCVKPNEGFWRQLCNYEQQ
.| .|   || .|    ||  | ..| | |.|
tlseaarqvrsnrllaypnvtflknllnlekq

0040439 (Phosphotyrosine protein) phosphatases II 121-241 7.9e-27 89.9 In-house 68-243 (249) alignment
Range on Protein: 121-241
Range on HMM: 68-243/249.0
AHCYEELQRNNITHILNVATGVVN-------------------------------------------VFAKDFTYKNIELLDLPETDLVAQLPQMFQFIN
.. .. |....||.|... . | .                                            . ...|.. |  .|.|....   ......||.
edfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfie

DGLQ-------AGAVLVHCNAGVSRSPAVVIAYLM-----HKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQ
  ..        | |||||.|||.|......||||     ... ..| .|.. .|.|||.. .|....|.|.....
avrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeall

0039614 (Phosphotyrosine protein) phosphatases II 124-241 1.5e-22 75.9 In-house 118-286 (297) alignment
Range on Protein: 124-241
Range on HMM: 118-286/297.0
YEELQRNNITHILNVATGVVN--------------------VFAKDFTYKNIE-----L-----------------LDLPETDLVAQLPQMFQFINDGL-
.. ......|.|... . | .                     . | ......      .                  |    .....| ........ | 
wrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvreala

---QAGAVLVHCNAGVSRSPAVVIAYLM-----HKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQ
   . | |||||.|||.|. ....||||     ... ... .|.. .|||||.. ......|.|.....
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydall

0038934 (Phosphotyrosine protein) phosphatases II 124-241 3.3e-21 71.2 In-house 35-174 (194) alignment
Range on Protein: 124-241
Range on HMM: 35-174/194.0
YEELQRNNITHILNV--------------ATGVVNVFAKDFTYKNIELLDLPETDL--VAQLPQMFQFIN------DGLQAGAVLVHCNAGVSRSPAVVI
.|||.|.........                      ...|.  .|| |.||  |   | .| ....|..      .  . |.|.||| ||..|.. .|.
ieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlva

AYLMHKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQ
|||.... .|. .| . .|| || . || .....|. . .
aYLiyrlgmsaeeAialfrekRpgaipnqdyleallkryk

subfamily_CDC14_pd Subfamily CDC14 124-225 1.3e-06 22.5 In-house 205-306 (328) alignment
Range on Protein: 124-225
Range on HMM: 205-306/328.0
YEELQRNNITHILNVATGVVNvfAKDFTYKNIELLDLPETDLVAQLPQ---MFQFINDGLqAGAVLVHCNAGVSRSPAVVIAYLMHKRLLSLGQAFNVVR
.|  ..||.|... .   . .  || || . ..  ||   |      .    |  | .    ||. ||| ||. |  ... .|||..  ..  .|   .|
leyfrknnvttvvrLnkklYd..akkftdaGfdhkDlffiDGstPsdaivkkfleiaeka.eGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlr

EQRPC
  || 
icrPG

0045450 (Phosphotyrosine protein) phosphatases II 125-241 2.3e-26 88.7 In-house 125-301 (307) alignment
Range on Protein: 125-241
Range on HMM: 125-301/307.0
EELQRNNITHILNVATGVVN-----------------------------VfAKDFTYKNIELLDL-----------------PETDLVAQLPQMFQFIND
. |.....|.|... . | .                             .  ...|. ..|. ||                 |....   . ....||. 
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfiee

GL-------QAGAVLVHCNAGVSRSPAVVIAYLMHKRL--------LSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQ
 .       . | |||||.|||.|......|||| ..|        ..| .|.. .|||||.. .|....|.|.....
vrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall

0040438 (Phosphotyrosine protein) phosphatases II 125-241 1.4e-22 75.8 In-house 104-273 (317) alignment
Range on Protein: 125-241
Range on HMM: 104-273/317.0
EELQRNNITHILNVATGVVN---------------------------VFAKDFTYKNIELLDL----------------PETDLVAQLPQMFQFINDGLQ
. ......|.|... . . .                           .  ...|. ..|. ||                |. ..   . ....|..   .
rmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavre

-----AGAVLVHCNAGVSRSPAVVIAYLM-----HKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQ
      | |||||.|||.|. ....||||     ... ... .|.. .|||||.. ......|.|. ...
aledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydall

subfamily_PRL_pd Subfamily PRL 125-224 8.8e-06 19.8 In-house 28-131 (151) alignment
Range on Protein: 125-224
Range on HMM: 28-131/151.0
EELQRNNITHILNVATGVVNvfAKDFTYKNIELLDL-------PETDLVAQLPQMFQFINDGLQAGAVLVHCNAGVSRSPAVVIAYLMHKRLlSLGQAFN
|||........  |     .  .. .  ..||.|||       | ...| .  .. .         .| ||| ||. |.| .|   |. . . .  .| .
eelkkeevktvvrvceptyd..teklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalalieaGm.kyedave

VVREQRP
..||.| 
firekrr

0043336 (Phosphotyrosine protein) phosphatases II 126-240 4.6e-18 61.1 In-house 107-273 (278) alignment
Range on Protein: 126-240
Range on HMM: 107-273/278.0
ELQRNNITHILNVATGV-----------------------------------------------VNVFAKDFTYKNIELLDLP-ETDLVAQLPQMFQFIN
 .. ...|.|... . |                                                  .   . |...   ..|  ..|. .. .... ..
mvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreal

DgLQAGAVLVHCNAGVSRSPAVVIAYLM-----HKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYE
.  . |.|||||.|||.|. .....||.     . . ..| .|.. .|||||.  ... ..|.|....
e.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal

0036941 (Phosphotyrosine protein) phosphatases II 128-241 1.4e-20 69.2 In-house 99-274 (297) alignment
Range on Protein: 128-241
Range on HMM: 99-274/297.0
QRNNITHILNVATGVVNVF-------------------------------AKDFTYKNIELLD----------------LPETDLVAQLPQMFQFINDGL
  .|.|.|... . | . .                                .|.|. ..|..|                 |. ..     ....||.  .
weqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvr

-------QAGAVLVHCNAGVSRSPAVVIAYLM--------HKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQ
       . | |||||.|||.|| ....|.||        . . ... .|.. .|||||.. ......|.|. ...
kvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeall

subfamily_STYXL1_pd Subfamily STYXL1 133-242 1.2e-20 67.3 In-house 39-152 (157) alignment
Range on Protein: 133-242
Range on HMM: 39-152/157.0
THILNVATGVVNVFAKD---FTYKNIELLDLPETDLVAQLPQMFQFINDGLQA-GAVLVHCNAGVSRSPAVVIAYLMHKRLLSLGQAFNVVREQRPCVKP
   .||..   ...| .       .|.. | .|.||. .| .. |||..  .   .|||  | |.||| ||.|||||... ..| .|.. ... .. |||
kahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiaylmyskkitlkkaykylkkCkenvkP

NEGFWRQLCNYEQQ
| .|  || ..|.|
nrafveqlseWekq

0051299 (Phosphotyrosine protein) phosphatases II 143-231 5.6e-14 47.7 In-house 175-273 (288) alignment
Range on Protein: 143-231
Range on HMM: 175-273/288.0
VNVFAKDFTYKNIELLDLPETDLVAQLPQMFQFINDGLQ-----AGAVLVHCNAGVSRSPAVVIAYLM-----HKRLLSLGQAFNVVREQRPCVKPNEG
..   . .|.. .  .. |. .    . ....|...  .      | |.|||.|||.|. ......|.     ... ... .|.. .|||||.. ... 
ldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpe

subfamily_PTPDC1_pd Subfamily PTPDC1 146-224 2.2e-10 35.2 In-house 79-156 (182) alignment
Range on Protein: 146-224
Range on HMM: 79-156/182.0
FAKDFTYKNIELLDLPETDLvAQLPQMFQFINDGLQAGAVLVHCNAGVSRSPAVVIAYLMHKRLLSLGQAFNVVREQRP
 ... .. |. . |   . |  .. .. . ..  || |.| ||| ||  |   .. .||.... |.  .| ..||..||
meqgiyvynfgwkDygvasl.eriLdivkvvafalqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrp

0046845 (Phosphotyrosine protein) phosphatases II 147-230 2.4e-13 45.6 In-house 167-260 (284) alignment
Range on Protein: 147-230
Range on HMM: 167-260/284.0
AKDFTYKNIELLDLP--ETDLVAQLPQMFQFINDGLQAGAVLVHCNAGVSRSPAVVIAYLMHKR--------LLSLGQAFNVVREQRPCVKPNE
 . | |...   . |   .||.. | .. .....  . | ..||| |||.|. ......|....         ... .|.. .|||||.   ..
vthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtl

PTPc_DSPc_SM00012 148-213 2.8e-08 29.3 In-house 3-70 (105) alignment
Range on Protein: 148-213
Range on HMM: 3-70/105.0
KDFTYKNIELLDLPE--TDLVAQLPQMFQFINDGLQAGAVLVHCNAGVSRSPAVVIAYLMHKRLLSLG
|.. |...    .||  ....  | .. .. |.  ... |.||| |||.|.  .| .......| .  
khyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket

DSPc_SM00195 148-227 5.9e-06 21.2 In-house 161-245 (263) alignment
Range on Protein: 148-227
Range on HMM: 161-245/263.0
KDFTYKNIELLDLP-ETDLVAQLPQMFQFINDGLqAGAVLVHCNAGVSRSPAVVIAYLMHKRLL-----SLGQAFNVVREQRPCVK
. . ||| .  ..| .|. | .| ....  ..    | ..||| |||.|. ..| . .. ..|      .. . .. .|.||| . 
tqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmv

PTPc_SM00194 148-227 5.9e-06 21.2 In-house 161-245 (263) alignment
Range on Protein: 148-227
Range on HMM: 161-245/263.0
KDFTYKNIELLDLP-ETDLVAQLPQMFQFINDGLqAGAVLVHCNAGVSRSPAVVIAYLMHKRLL-----SLGQAFNVVREQRPCVK
. . ||| .  ..| .|. | .| ....  ..    | ..||| |||.|. ..| . .. ..|      .. . .. .|.||| . 
tqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmv

0047943 (Phosphotyrosine protein) phosphatases II 151-237 2.5e-15 52.1 In-house 151-265 (273) alignment
Range on Protein: 151-237
Range on HMM: 151-265/273.0
TYKNIELLD----------------LPETDLVAQLPQMFQFINDGL-------QAGAVLVHCNAGVSRSPAVVIAYLM-----HKRLLSLGQAFNVVREQ
|  ..|| .                 |. .  ..| ....||..         . | |.|||.|||.|. ......|.     ... ... .|.. .|.|
tvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsq

RPCVKPNEGFWRQLC
||.. ... ..|.|.
Rpgmvqtpeqyrfly

subfamily_DSP23_pd Subfamily DSP23 151-225 8.8e-08 26.9 In-house 53-127 (148) alignment
Range on Protein: 151-225
Range on HMM: 53-127/148.0
TYKNIELLDLPETdLVAQLPQMFQFINDG-LQAGAVLVHCNAGVSRSPAVVIAYLMHKRLLSLGQAFNVVREQRPC
|...... |      . |. .. . ...   .. || |||  |  |. ...  ||...| |. ..|   ||..|| 
tlvrlriddyhpp.aleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpg

0050432 (Phosphotyrosine protein) phosphatases II 152-230 1.3e-12 43.1 In-house 204-285 (308) alignment
Range on Protein: 152-230
Range on HMM: 204-285/308.0
YKNIELLDLPETdlVAQLPQMFQFINDGLQAGAVLVHCNAGVSRSPAVVIAYLM-----HKRLLSLGQAFNVVREQRPCVKPNE
|.| .  . |.   ...| ........ |. | ..|||.|||.|. ......|.     ... ... .|.. .|||||.. ...
ytnWpdhgvPps..peilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp

subfamily_Laforin_pd Subfamily Laforin 152-226 5.8e-09 29.1 In-house 79-154 (183) alignment
Range on Protein: 152-226
Range on HMM: 79-154/183.0
YKNIELLDLPETDLVAQLPQMFQFINDGLQAG-AVLVHCNAGVSRSPAVVIAYLMHKRLLSLGQAFNVVREQRPCV
|  . . ||     | .|||   ..   |. |  | ||||||| || |.|  .|..    || .    .  .||.|
yiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvv

subfamily_RNGTT_pd Subfamily RNGTT 159-227 2.7e-07 24.5 In-house 90-158 (189) alignment
Range on Protein: 159-227
Range on HMM: 90-158/189.0
DLPETDLVAQLPQMFQFINDGLQAGAVLVHCNAGVSRSPAVVIAYLMHKRLLSLGQAFNVVREQRPCVK
. ||.. |... .. .  ..      . |||  |  |.  ....||..|.  |. .| .. .. ||   
eaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGi

subfamily_MSG5_pd Subfamily MSG5 162-240 2.6e-12 40.2 In-house 78-157 (165) alignment
Range on Protein: 162-240
Range on HMM: 78-157/165.0
ETDLVAQLPQMFQFINDGL-QAGAVLVHCNAGVSRSPAVVIAYLMHKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYE
.. .| .|... . |     .   .||||. |.||| ....||.|.   ||| .|.. .. .   ..|. |.  || ..|
dskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewe

Y_phosphatase Protein-tyrosine phosphatase 167-224 6.4e-06 21.1 Pfam-A 153-217 (235) alignment
Range on Protein: 167-224
Range on HMM: 153-217/235.0
AQLPQMFQFINDGL--QAGAVLVHCNAGVSRSPAVVIAYLMHKRLLS-----LGQAFNVVREQRP
 .| .. . ..     . | |.||| |||.|.  .| . .. ..| .     . |. . .|.|||
kslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRp

Y_phosphatase Protein-tyrosine phosphatase 167-224 6.4e-06 21.1 In-house 153-217 (235) alignment
Range on Protein: 167-224
Range on HMM: 153-217/235.0
AQLPQMFQFINDGL--QAGAVLVHCNAGVSRSPAVVIAYLMHKRLLS-----LGQAFNVVREQRP
 .| .. . ..     . | |.||| |||.|.  .| . .. ..| .     . |. . .|.|||
kslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRp

0048567 (Phosphotyrosine protein) phosphatases II 179-240 9.5e-06 20.1 In-house 71-135 (157) alignment
Range on Protein: 179-240
Range on HMM: 71-135/157.0
GLQAGAVLVHCNAGV---SRSPAVVIAYLMHKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYE
 |. .|. ||| ||    .|.  .. .||. .  ..  .|.. .|  ||  .|    .  |..|.
elagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyllslyn