Gene DSP19 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP19
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP010_AA protein Get Run
NvecP010_AA_103-242 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0049772 (Phosphotyrosine protein) phosphatases II 80-242 1.1e-30 102.9 In-house 118-272 (314) alignment 
Range on Protein: 80-242
Range on HMM: 118-272/314.0
EGNSPIIVDT---------------------GERTYGFcedtkhdvtlakieeglflgSQDGAHCYEELQrnnithilnvatGVV---NVFAKD-FTYKN
. |. .|| .                      . . ..                    ..  |. .|.|.            ...   . | .  ..|..
dlnvrdivmsrdevladelsrLdaAlgKtpllildgng....................neptaadlellk............eelydpelferlgikylr

IELLDlPETDLVAQLPQMFQFINDGLQAGAVLVHCNAGVSRSP-AVVIAYLMHKRLLSLGQAFNVVREQRPcVKPNEGFWRQLCNYEQQ
| . | ....| ........||..  . |.|||||.||..|.. .||.||||... .|| .|.. ||..|| ..||.||..||..||..
ipvpD.gsaplledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefi
subfamily_DSP19_pd Subfamily DSP19 95-243 3.1e-71 232.6 In-house 1-150 (152) alignment 
Range on Protein: 95-243
Range on HMM: 1-150/152.0
GFCEDTKHDVTLAKIEEGLFLGSQDGAHCYEELQRNNITHILNVATGVVNVFAKDFTYKNIELLDLPETDLVAQLPQMFQFINDGLQA-GAVLVHCNAGV
||.||.|.|......|. |.|||||.|...|.|....|||||||||||.|||.|||||..||.||||||||...|.....||...... |||||||||||
gfveDlkedlevgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGv

SRSPAVVIAYLMHKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQQK
|||..|||||||.|. ||| .|...|||.|||.||||||..||..||...
SRsasvviaylmkkeelsleealelvrearpcikPneGFikqLkeyeael
subfamily_DSP1_pd Subfamily DSP1 101-242 1.6e-41 136.1 In-house 14-155 (163) alignment 
Range on Protein: 101-242
Range on HMM: 14-155/163.0
KHDVTLaKIEEGLFLGSQDGAHCYEELQRNNITHILNVATGVVNVFAKDFTYKNIELLDLPETDLVAQLPQMFQFINDGL-QAGAVLVHCNAGVSRSPAV
 .| .  || . |.|||.  |   | |....||.||||.. . ||| . |.||...| | |. |. . . .. .||..   . | ||.||.||.||| ..
lydPve.kildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstl

VIAYLMHKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQQ
..||||... .|| .||. |...|....|| || .|| |||..
claylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekk
subfamily_DSP8_pd Subfamily DSP8 101-242 1.9e-25 83.3 In-house 10-153 (159) alignment 
Range on Protein: 101-242
Range on HMM: 10-153/159.0
KHDVTLAKIEEGLFLGSQDGAHCYEELQRNNITHILNVATGV-VNVFAKDFTYKNIELLDLPETDLVAQLPQMFQFINDGLQ-AGAVLVHCNAGVSRSPA
 .|| . .| . |.||||  .   | |....|...||. .      . |.  .  . . |  . .|.  ... ..||.   .  | ||||. || |||..
vadvgptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsat

VVIAYLMHKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQQ
|.|||.|..  .|| .|.. |.|.|| ..||  |  || .||..
vaiayimktlemsldeayrfvkekrptispnlnflgqLleyeke
subfamily_DSP10_pd Subfamily DSP10 102-242 1.6e-36 119.6 In-house 10-152 (159) alignment 
Range on Protein: 102-242
Range on HMM: 10-152/159.0
HDVTLAKIEEGLFLGSQDGAHCYEELQRNNITHILNVATGVVNVFAK-DFTYKNIELLDLPETDLVAQLPQMFQFINDGLQAG-AVLVHCNAGVSRSPAV
. . ....   |||||. .|.  . |.| |||..|||.| | | |.. ...|| |.. |  . .|  .  . ..||..  . |  |||||.||.||| .|
etapasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatv

VIAYLMHKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQQ
||||||... ||| .|.. |.|.|| . || .|  || ..|..
viaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefeke
0045098 (Phosphotyrosine protein) phosphatases II 102-242 2.5e-30 101.2 In-house 18-270 (278) alignment 
Range on Protein: 102-242
Range on HMM: 18-270/278.0
HDVTLAKIEEGLFLGSQD-----------------------------------------GAHCYEELQRNNITHILNVA---------------------
.     .|...|.||..|                                          |. .. |. ..||.|....                     
llgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggslt

-------------------------------TGVVNVFAKDFTYKNIELLDLPETDLVAQLPQMFQFINDGL---------------QAGAVLVHCNAGV
                               ..  . . . . |....  . |........ ....||.. |               . | |||||.|||
ygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGv

SRSPAVVIAYLMHKR---LLSLGQAFNVVREQRPC-VKPNEGFWRQLCNYEQQ
.|. ..|.|||| ..    ..| .|.. .|.|||. . .|....|.|. ....
gRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyeflle
0041856 (Phosphotyrosine protein) phosphatases II 102-241 5.1e-30 99.8 In-house 15-170 (182) alignment 
Range on Protein: 102-241
Range on HMM: 15-170/182.0
HDVTLAKIEEGLFLGSQDG--------------AHCYEELQRNNITHILNVAtgVVNVFAKDF-----TYKNIELLDLPETDlvaqLPQMFQFINDGLQ-
|.  | .| ..|.|||. .              |. .. |....||.|.|..   .. .....     .|...   | . .|    |.....||.. |. 
hsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd....ldelldfieevlee

AGAVLVHCNAGVSRSPAVVIAYLMHKRLLSLGQAFNVVREQRP--CVKPNEGFWRQLCNYEQ
 |.|||||.|||.|....|.||||.|. .|| .|.. ||..||  .. || .|..||. .| 
ggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallel
PTEN_1 102-242 1.7e-29 98.0 In-house 32-190 (196) alignment 
Range on Protein: 102-242
Range on HMM: 32-190/196.0
HDVTLA-----KIEEGLFLGSQDGAHC-YEELQRNNITHILNVATGVVN---------VFAKDFTYKNIELLDLPETDLVAQLPQMFQFINDGLQ---AG
.... .     .|.|||..||.. . .  ..|. ..||...|.. .  .          |.....|....  | .  .|   .    .||.  |.    .
mgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngn

AVLVHCNAGVSRSPAVVIAYLMHKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQQ
.||||| ||..||  ||.||||.|. |.  .|.  |||.||.. || .....| .|...
vVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfae
subfamily_DSP6_pd Subfamily DSP6 103-242 3.1e-37 121.5 In-house 11-153 (158) alignment 
Range on Protein: 103-242
Range on HMM: 11-153/158.0
DVTLAKIEEGLFLGSQDGAHCYEELQRNNITHILNVATGVVNVFAK--DFTYKNIELLDLPETDLVAQLPQMFQFINDGLQAG-AVLVHCNAGVSRSPAV
. ....| . |.|||.. |.  | |.. .| ..|||.. . |.|..  ...|..| . |  ...| . .|. ..||... ..  .||||| ||.||| .|
aefpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtv

VIAYLMHKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQQ
..||||.|. ||| .|...|..... . ||  |  || ..|..
tlaylmkklalslndaydlvkkrksnisPnfnfmgqlldfers
0046846 (Phosphotyrosine protein) phosphatases II 103-242 6.7e-28 93.0 In-house 9-171 (176) alignment 
Range on Protein: 103-242
Range on HMM: 9-171/176.0
DVTLAKIEEGLFLGSQD----------GAHCYEELQRNNITHILNVATGV-----------VNVFAKDFTYKNIELLDLPETDLvAQLPQMFQFINDGLQ
|  |  | ..|.|||             |.  |.|....||...|. . |             . . ...|...   |    || ..|.....||.. |.
dldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealk

AG-AVLVHCNAGVSRSPAVVIAYLMHK-RLLSLGQAFNVVREQRP-CVKPNEGFWRQLCNYEQQ
.|  ||||| ||..|....|.|||... . ||. .|.  |||||| .. ......|.|  .|..
eggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefell
0037934 (Phosphotyrosine protein) phosphatases II 104-242 3.4e-24 81.2 In-house 37-240 (243) alignment 
Range on Protein: 104-242
Range on HMM: 37-240/243.0
VTLAKIEEGLFLGSQ--------DGAHCYEELQRNNITHILNVATGV----------------------------------------VNVFAKDFTYKNI
  | .. ..|.....        | |. .. |....||.|... . |                                        .|. ..|.|. .|
anliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvi

ELLDLPETD----L-VAQLPQMFQFIND----------GLQAGAVLVHCNAGVSRSPAVVIAYLMHKR-LLSLGQAFNVVREQRPC-VKPNEGFWRQLCN
 .. ||  |      ...| ........            . | ||||| |||.|. ....||||...  ..| .|.. .|||||. . ......|.|  
hyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflye

YEQQ
....
alle
0042113 (Phosphotyrosine protein) phosphatases II 104-241 3.7e-24 80.9 In-house 45-240 (245) alignment 
Range on Protein: 104-241
Range on HMM: 45-240/245.0
VTLAKIEEGLFLGSQDGAHCYE----ELQRNNITHILNVATGV----------------------------------------------VNVFAKDFTYK
|.. .| ........  .. .|     |....||.|... . .                                               .   ....| 
vdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyh

NIELLDLPETDLVAQLPQMFQFINDGLQ---AGAVLVHCNAGVSRSPAVVIAYLM-----HKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQ
 .   | ...||...| ....|... |.    | |||||.|||.|. ....||||     . . .|| .|.  .|.|||.. ......|.|  ...
ylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall
subfamily_DSP14_pd Subfamily DSP14 105-242 3.2e-39 128.4 In-house 6-143 (157) alignment 
Range on Protein: 105-242
Range on HMM: 6-143/157.0
TLAKIEEGLFLGsQDGAHCYEELQRNNITHILNVATGVVNVFAKDFTYKNIELLDLPETDLVAQLPQMFQFINDG-LQAGAVLVHCNAGVSRSPAVVIAY
.|..|.. |||.   .|   |.|....||.|.||.. ..|  .||. . .. . | ||..|.. . .. . |..   ..|..|||| |||||| ....||
alsqitpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclay

LMHKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQQ
||. . ||| .|...|...|| ..|| |||.|| .||..
lmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkk
0036282 (Phosphotyrosine protein) phosphatases II 105-241 2.1e-27 91.3 In-house 11-167 (174) alignment 
Range on Protein: 105-241
Range on HMM: 11-167/174.0
TLAKIEEGLFLGSQDGAhCYEELQRNNITHILNVATGVVNV---------------FAKDFTYKNIELLDLPETDLVAqLPQMFQFINDGLQA---GAVL
 |  | ..|..|.   |  .|.|....||..... . . .                   ...|. .   |  . ||   | ....|... |.    | ||
dlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvl

VHCNAGVSRSPAVVIAYLMHKRLL-SLGQAFNVVREQR---PCVKPNEGFWRQLCNYEQ
|||.|||.|....|.||||...|| || .|...|||.|   |.. ......|.|  .|.
VHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfek
0044763 (Phosphotyrosine protein) phosphatases II 106-242 2.2e-39 130.2 In-house 23-169 (178) alignment 
Range on Protein: 106-242
Range on HMM: 23-169/178.0
LAKIEEGLFLGSQDGAHCYEELQRNNITHILNVATGVVNVFAKD---------FTYKNIELLDLPETDLVAQLPQMFQFINDG--LQAGAVLVHCNAGVS
. .| .||.|||.  |. .| |....||||.|... . . | |.         ..|..| . | ...|| ........||..    . |.|||||.|||.
aseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvg

RSPAVVIAYLMHKRLLSLGQAFNVVREQRPcVKPNEGFWRQLCNYEQQ
||...|.||||.|. ||| .|.. |||.|| . ||.|..|||. .|..
RsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelr
subfamily_DSP15_pd Subfamily DSP15 106-243 1.3e-31 103.7 In-house 2-139 (151) alignment 
Range on Protein: 106-243
Range on HMM: 2-139/151.0
LAKIEEGLFLGSQDGAHCYEELQRNNITHILNVATgVVNVFAKDFTYKNIELLDLPETDLVAQLPQMFQFINDG-LQAGAVLVHCNAGVSRSPAVVIAYL
. |. .||.||    ..  | |...||||||.|     . . ||..|| |.. | |...|   . .  .|| .  |. ..||||| ||||||  .|.|||
iskvlpglylgnfrdskdeelLkeknithilsvhd.nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYl

MHKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQQK
|    |.  .|..|....| . .|| || ||| .||..|
mtvtelnwrdalevikaaRsvanPnfGfkrqlkeyektk
subfamily_STYX_pd Subfamily STYX 106-241 2.5e-27 89.0 In-house 12-155 (166) alignment 
Range on Protein: 106-241
Range on HMM: 12-155/166.0
LAKIEEGLFLGSQDGAH--CYEELQRNNITHILNV-----ATGVVNVFAKDFTYKNIELLDLPETDLVAQLPQMFQFINDGLQAG-AVLVHCNAGVSRSP
. .|  |||||    |     | |... ||||. .     |. .   | ..| |  ... | .  ...  ||.. .||.| || |  |||| |||.||| 
mqeilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsa

AVVIAYLMHKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQ
|.||||.|    |   .||  |.|.| |..||||| .|| .|| 
alviayimetyglkyreafayvqerrfcinpnegfvsqlkeyea
subfamily_Slingshot_pd Subfamily Slingshot 107-240 1.5e-40 132.3 In-house 20-154 (169) alignment 
Range on Protein: 107-240
Range on HMM: 20-154/169.0
AKIEEGLFLGSQDGAHCYEELQRNNITHILNVATGVVNVFAKDFTYKNIELLDLPETDLVAQLPQMFQFINDGLQAG-AVLVHCNAGVSRSPAVVIAYLM
.|| . ..|||.  |  .|||..|....||||.  . | |...|.|.|| . | .||||...  . ..||.   ..|  |||||  ||||| ..|||| |
skifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayam

HKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYE
..  ||| .|.. |.|.| ..|||.||..|| .||
keyglsleealeyvkerrsvikPnkgflkqleeye
subfamily_DSP12_pd Subfamily DSP12 107-241 3.2e-39 128.8 In-house 3-141 (155) alignment 
Range on Protein: 107-241
Range on HMM: 3-141/155.0
AKIEEGLFLGSQDGAHCYEELQRNNITHILNVATGVVNVF---AKDFTYKNIELLDLPETDLVAQLPQMFQFINDGL-QAGAVLVHCNAGVSRSPAVVIA
 .|..||.||.   .. .| |.  .|||.| |..  .. .   ..  ..|.|..|| ||.|..  |.....||...| . |||||||.|||||| ..|||
srilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviA

YLMHKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQ
|||.|  ||| .|...|.|..| ..||||| .||  .|.
YlmkkeklslekAlklvkekkpeiepNegFleQLklfek
0048076 (Phosphotyrosine protein) phosphatases II 107-242 1.1e-35 117.7 In-house 5-141 (145) alignment 
Range on Protein: 107-242
Range on HMM: 5-141/145.0
AKIEEGLFLGSQDGAHCYEELQRNNITHILNVATGVVNVFAKDFTYKNIELLDLPETDLVAQLPQMFQFINDGLQAG-AVLVHCNAGVSRSPAVVIAYLM
..| .||.|||.  |. .|.|....||..||...   ........| .. . | .. || ..|.....||.. |..|  |||||.|||.|....|.||||
seilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylm

HKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQQ
... .|| .|.. ||.|||.. ||.|..|.|. .|..
lllgvsleealelvrsqrpgavpnpgqlrflyefele
0048179 (Phosphotyrosine protein) phosphatases II 107-241 5.9e-35 115.4 In-house 5-142 (144) alignment 
Range on Protein: 107-241
Range on HMM: 5-142/144.0
AKIEEGLFLGSQDGAHCYEELQRNNITHILNVATGVVNVFAKDF--TYKNIELLDLPETDLVAQLPQMFQFINDGLQ-AGAVLVHCNAGVSRSPAVVIAY
..| .||.|||.  |. .|.|....||...|....  . | ...  .| .. . | .  || ..|.....||.. |.  | |||||.|||.|....|.||
seilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaay

LMHKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQ
||.|. ||| .|.. ||..||.. ||.|..|.|..||.
lmkklglsleealalvrsrrpgavpnpgqlrfLleyek
PTPc_motif_SM00404 108-241 1.3e-38 127.0 In-house 4-139 (140) alignment 
Range on Protein: 108-241
Range on HMM: 4-139/140.0
KIEEGLFLGSQDGAHCYEELQRNNITHILNVATGVVN-VFAKDFTYKNIELLDLPETDLVAQLPQMFQFINDGLQAGA-VLVHCNAGVSRSPAVVIAYLM
.| ..|.|||.. |   . |. ..|||..||.. |..    ..|....|.| |  ...|...|... .||..  . |  ||||| |||||| ...|||||
rilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlm

HKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQ
..| ||| .|...|.|.||...||..|.|||..||.
ryrqlslaeayefvkerRpiispnlnfvrqLieyek
subfamily_LRR-DSP_pd Subfamily LRR-DSP 108-242 2.5e-36 119.1 In-house 122-257 (263) alignment 
Range on Protein: 108-242
Range on HMM: 122-257/263.0
KIEEGLFLGSQDGAHCYEELQRNNITHILNVATGVVNVFAKDFTYKNI-ELLDLPETDLVAQLPQMFQFINDGLQAGAVLVHCNAGVSRSPAVVIAYLMH
.| ..||||..| |     |. ...||||   . .  .| | | |  | .. | .| |.   . ..  ||..| . | ||||| |||||| ..||.|||.
eiidklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkGGvlvhcraGvsrsstlvisylmk

KRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQQ
|. | . .|...| ..|| ..|| ||  ||  ||..
kqrlkfkealdlvikkrpriqPnpGfkdqlkkyekk
subfamily_DSP3_pd Subfamily DSP3 108-242 1.9e-31 102.9 In-house 13-156 (162) alignment 
Range on Protein: 108-242
Range on HMM: 13-156/162.0
KIEEGLFLGSQDGAHCYEELQRNNITHILNVATGVV-NV-----FA--KDFTYKNIELLDLPETDLVAQLPQMFQFINDGLQA--GAVLVHCNAGVSRSP
 . ..|..| .. |.  ..|..  |||.|| | | . .|     |    ...|  .|. | ||.|| .   . ..||.. |.   | |||||..|||||.
evypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsa

AVVIAYLMHKRLLSLGQAFNVVREQRpCVKPNEGFWRQLCNYEQQ
..|.|||| .| ..| .| . ||..| .. ||||| .||......
tlvlayLmirrkmtlveairtvrkkR.eilPneGFlkqLaeldee
0051082 (Phosphotyrosine protein) phosphatases II 108-239 2.5e-23 77.7 In-house 10-149 (151) alignment 
Range on Protein: 108-239
Range on HMM: 10-149/151.0
KIEEGLFLGSQDGAHCYEELQRNNITHILNVATGVVNVFAK------DFTYKNIELLDLPETDLVAQLPQMFQFINDGLQ--AGAVLVHCNAGVSRSPAV
 ...||.....  |. .|.|....|..|.|. . . . . .      ......| .|| |...|   .... .|..  |.   | |||||.||..|. ..
yvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtl

VIAYLMHKRlLSLGQAFNVVREQRP-CVKPNEGFWRQLCNY
|..|||. . .|| .|.. .|..|| .| ||..|. ||. .
valylmllg.vsleealeeyrlkrpgvvqpnqqflfqlfal
0051429 (Phosphotyrosine protein) phosphatases II 108-241 2.2e-20 68.9 In-house 18-222 (272) alignment 
Range on Protein: 108-241
Range on HMM: 18-222/272.0
KIEEGLFLGSQD----GAHCYEELQRNNITHILNVATGVVNVFAK------DFTYKNIELLDLPETDLV-------------------------------
.. .|... |.      |. .. |....|..|... . .   . |      ...| .. .||  ...                                 
vvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsag

--------------------AQLPQMFQFINDglqAGAVLVHCNAGVSRSPAVVIAYLMHkRLLS--------------LGQAFNVVREQRPCVKPNEGF
                     .| .......|    |.|||||.||..|.  || ..|.  . .|              | .| . .|.|||.. ..|..
earevmhlhytdwpdhgvpqeallellellld...ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeq

WRQLCNYEQ
...|.....
ylflyeall
subfamily_PTPMT1_pd Subfamily PTPMT1 108-242 3.4e-17 57.4 In-house 22-167 (171) alignment 
Range on Protein: 108-242
Range on HMM: 22-167/171.0
KIEEGLFLGSQDGAHCYEEL-QRNNITHILNVATGV----VNVFAKDFTYKNIELLDLPETDLV-----AQLPQMFQFINDGLQAG-AVLVHCNAGVSRS
.|.. ..||     .  .|| . .|.  ....        .    ....  ..| | |. .|       ..| .  .||..  . |  | |||.|| .||
riDdtvilGalPfrslikeLiekenvkavvslneeyelkalansteewkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRs

PAVVIAYLMHKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQQ
 ..|..|||.|. ||. .| ......|. .. ..  |..| .||..
atlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeek
subfamily_MKPLT_pd Subfamily MKPLT 109-241 8.1e-31 100.8 In-house 25-158 (164) alignment 
Range on Protein: 109-241
Range on HMM: 25-158/164.0
IEEGLFLGSQDGAHCYEELQRNNITHILNVATGVVNVFAKDFTYKNIELLDLPETDLVAQLPQMFQFINDGLQA-GAVLVHCNAGVSRSPAVVIAYLMHK
.|. |.||  . |   . |.  .||||.||...  . |.| . | .... | ... | . | .. .|. | ... | |||||. |.||| .| .|.|.. 
ledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiks

RLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQ
.   |..|.. ..|.| .|.|| || .||...|.
kgwtlkeayeylkerrsivapnrGflkqlakfee
subfamily_MKPLV_pd Subfamily MKPLV 109-241 8.1e-31 100.8 In-house 25-158 (164) alignment 
Range on Protein: 109-241
Range on HMM: 25-158/164.0
IEEGLFLGSQDGAHCYEELQRNNITHILNVATGVVNVFAKDFTYKNIELLDLPETDLVAQLPQMFQFINDGLQA-GAVLVHCNAGVSRSPAVVIAYLMHK
.|. |.||  . |   . |.  .||||.||...  . |.| . | .... | ... | . | .. .|. | ... | |||||. |.||| .| .|.|.. 
ledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiks

RLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQ
.   |..|.. ..|.| .|.|| || .||...|.
kgwtlkeayeylkerrsivapnrGflkqlakfee
0049260 (Phosphotyrosine protein) phosphatases II 109-241 4.7e-29 96.4 In-house 11-147 (152) alignment 
Range on Protein: 109-241
Range on HMM: 11-147/152.0
IEEGLFLGSQDGAHCYEELQRNNITHILNVATGVVN---VFAKDFTYKNIELLDLPETDLVAQLPQMFQFIND--GLQAGAVLVHCNAGVSRSPAVVIAY
.  ....|... |. .. |....||.|... . . .    ... ..|...   | .  ||   |.....||.     . | ||||| |||.|....|.||
fiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaay

LMHkRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQ
||. . .|| .|.. |||.||.. ||.|..|.| ..|.
lml.lgvsleeavalvrekRpgavpnpgqlrflyefek
0043147 (Phosphotyrosine protein) phosphatases II 111-242 2.2e-30 101.0 In-house 24-159 (172) alignment 
Range on Protein: 111-242
Range on HMM: 24-159/172.0
EGLFLGSQDGAHCYEELQRNNITHILNVATG---VVNVFAKDFTYKNIELLDLPETdLVAQLPQMFQFIND---GLQAGAVLVHCNAGVSRSPAVVIAYL
 ...... . |. .. |....||||.|. .      ...  ...|  .   | . . | ..|.....||..     . |.||||| |||.|....|.|||
atqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaayl

MHkRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQQ
|. . ||| .|.. |||.||.. .|....|.|. .|..
ml.lglsleeavalvrekRpgavqnpsqyrflyyfekl
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 112-242 4.1e-38 124.1 In-house 9-151 (154) alignment 
Range on Protein: 112-242
Range on HMM: 9-151/154.0
GLFLGSQDGAHCYEELQRNNITHILNVATGVVNVFAKD---------FTYKNIELLDLPETDLVAQLPQMFQFINDGL---QAGAVLVHCNAGVSRSPAV
 |...|.| |    .|| .||..||||..|. |.|...         . | |.|| | .. |.. .| . |.||.| .   . . ||||...||||| |.
flyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaal

VIAYLMHKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQQ
.|.|||.|. .|| .|. .... |. .|||.|| .||. .|..
lisylmdklkislslalellkdsryiikPnqGflkqleifeke
DSPc Dual specificity phosphatase, catalytic domain 113-242 1e-35 117.5 Pfam-A 1-133 (133) alignment 
Range on Protein: 113-242
Range on HMM: 1-133/133.0
LFLGSQDGAHcYEELQRNNITHILNVATGVVN---VFAKDFTYKNIELLDLPETDLVAQLPQMFQFINDGLQAG-AVLVHCNAGVSRSPAVVIAYLMHKR
|.|||.  |   . |. ..||...||.. | |      ....| .| . |  ||.....|... .||..  | |  |||||.||.|||....||||| ..
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

LLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQQ
 ||| .|...|.|.|... ||.||.|||..||..
nlslneAyefvkerrskispnagflrqLleyerk
DSPc Dual specificity phosphatase, catalytic domain 113-242 1e-35 117.5 In-house 1-133 (133) alignment 
Range on Protein: 113-242
Range on HMM: 1-133/133.0
LFLGSQDGAHcYEELQRNNITHILNVATGVVN---VFAKDFTYKNIELLDLPETDLVAQLPQMFQFINDGLQAG-AVLVHCNAGVSRSPAVVIAYLMHKR
|.|||.  |   . |. ..||...||.. | |      ....| .| . |  ||.....|... .||..  | |  |||||.||.|||....||||| ..
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

LLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQQ
 ||| .|...|.|.|... ||.||.|||..||..
nlslneAyefvkerrskispnagflrqLleyerk
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 113-242 7.2e-28 91.0 In-house 15-146 (148) alignment 
Range on Protein: 113-242
Range on HMM: 15-146/148.0
LFLGSQDGAHCYEELQRNNITHILNVATGVVNVFAKDFT-YKNIELLDLPETDLVAQLPQMFQFINDGLQAG-AVLVHCNAGVSRSPAVVIAYLMHKRLL
|||||.  |  .| |.  ..|.| | .    |....    | ...| | |. || |  ... .|..   ..|  ||||.. ||||| |.....|.. .  
LFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkrv

SLGQAFNVVREQRPCVKPNEGFWRQLCNYEQQ
|| .|...|...|. |.|| || .|| ..||.
slkealalvkskrryvdpnlgfLkqLaeleqa
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 116-242 1.2e-16 54.1 In-house 9-140 (145) alignment 
Range on Protein: 116-242
Range on HMM: 9-140/145.0
GSQDGAHCYEELQRNNITHILNVATGVV----NVFAKDFTYKNIELLDLPETDLVAQLPQMFQFINDGLQAGA-VLVHCNAGVSRSPAVVIAYLMHKRLL
||   |.    ||   |. |.|.|.| .    .. .....   |   ||   ||   . .. .||. | . || |.||| |||||| .| .|.||.   .
gsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnm

SLGQAFNVVREQRPCVKPNEGFWRQLCNYEQQ
.| .|   || .|    ||  | ..| | |.|
tlseaarqvrsnrllaypnvtflknllnlekq
0040439 (Phosphotyrosine protein) phosphatases II 121-241 7.9e-27 89.9 In-house 68-243 (249) alignment 
Range on Protein: 121-241
Range on HMM: 68-243/249.0
AHCYEELQRNNITHILNVATGVVN-------------------------------------------VFAKDFTYKNIELLDLPETDLVAQLPQMFQFIN
.. .. |....||.|... . | .                                            . ...|.. |  .|.|....   ......||.
edfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfie

DGLQ-------AGAVLVHCNAGVSRSPAVVIAYLM-----HKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQ
  ..        | |||||.|||.|......||||     ... ..| .|.. .|.|||.. .|....|.|.....
avrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeall
0039614 (Phosphotyrosine protein) phosphatases II 124-241 1.5e-22 75.9 In-house 118-286 (297) alignment 
Range on Protein: 124-241
Range on HMM: 118-286/297.0
YEELQRNNITHILNVATGVVN--------------------VFAKDFTYKNIE-----L-----------------LDLPETDLVAQLPQMFQFINDGL-
.. ......|.|... . | .                     . | ......      .                  |    .....| ........ | 
wrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvreala

---QAGAVLVHCNAGVSRSPAVVIAYLM-----HKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQ
   . | |||||.|||.|. ....||||     ... ... .|.. .|||||.. ......|.|.....
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydall
0038934 (Phosphotyrosine protein) phosphatases II 124-241 3.3e-21 71.2 In-house 35-174 (194) alignment 
Range on Protein: 124-241
Range on HMM: 35-174/194.0
YEELQRNNITHILNV--------------ATGVVNVFAKDFTYKNIELLDLPETDL--VAQLPQMFQFIN------DGLQAGAVLVHCNAGVSRSPAVVI
.|||.|.........                      ...|.  .|| |.||  |   | .| ....|..      .  . |.|.||| ||..|.. .|.
ieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlva

AYLMHKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQ
|||.... .|. .| . .|| || . || .....|. . .
aYLiyrlgmsaeeAialfrekRpgaipnqdyleallkryk
subfamily_CDC14_pd Subfamily CDC14 124-225 1.3e-06 22.5 In-house 205-306 (328) alignment 
Range on Protein: 124-225
Range on HMM: 205-306/328.0
YEELQRNNITHILNVATGVVNvfAKDFTYKNIELLDLPETDLVAQLPQ---MFQFINDGLqAGAVLVHCNAGVSRSPAVVIAYLMHKRLLSLGQAFNVVR
.|  ..||.|... .   . .  || || . ..  ||   |      .    |  | .    ||. ||| ||. |  ... .|||..  ..  .|   .|
leyfrknnvttvvrLnkklYd..akkftdaGfdhkDlffiDGstPsdaivkkfleiaeka.eGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlr

EQRPC
  || 
icrPG
0045450 (Phosphotyrosine protein) phosphatases II 125-241 2.3e-26 88.7 In-house 125-301 (307) alignment 
Range on Protein: 125-241
Range on HMM: 125-301/307.0
EELQRNNITHILNVATGVVN-----------------------------VfAKDFTYKNIELLDL-----------------PETDLVAQLPQMFQFIND
. |.....|.|... . | .                             .  ...|. ..|. ||                 |....   . ....||. 
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfiee

GL-------QAGAVLVHCNAGVSRSPAVVIAYLMHKRL--------LSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQ
 .       . | |||||.|||.|......|||| ..|        ..| .|.. .|||||.. .|....|.|.....
vrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall
0040438 (Phosphotyrosine protein) phosphatases II 125-241 1.4e-22 75.8 In-house 104-273 (317) alignment 
Range on Protein: 125-241
Range on HMM: 104-273/317.0
EELQRNNITHILNVATGVVN---------------------------VFAKDFTYKNIELLDL----------------PETDLVAQLPQMFQFINDGLQ
. ......|.|... . . .                           .  ...|. ..|. ||                |. ..   . ....|..   .
rmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavre

-----AGAVLVHCNAGVSRSPAVVIAYLM-----HKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQ
      | |||||.|||.|. ....||||     ... ... .|.. .|||||.. ......|.|. ...
aledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydall
subfamily_PRL_pd Subfamily PRL 125-224 8.8e-06 19.8 In-house 28-131 (151) alignment 
Range on Protein: 125-224
Range on HMM: 28-131/151.0
EELQRNNITHILNVATGVVNvfAKDFTYKNIELLDL-------PETDLVAQLPQMFQFINDGLQAGAVLVHCNAGVSRSPAVVIAYLMHKRLlSLGQAFN
|||........  |     .  .. .  ..||.|||       | ...| .  .. .         .| ||| ||. |.| .|   |. . . .  .| .
eelkkeevktvvrvceptyd..teklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalalieaGm.kyedave

VVREQRP
..||.| 
firekrr
0043336 (Phosphotyrosine protein) phosphatases II 126-240 4.6e-18 61.1 In-house 107-273 (278) alignment 
Range on Protein: 126-240
Range on HMM: 107-273/278.0
ELQRNNITHILNVATGV-----------------------------------------------VNVFAKDFTYKNIELLDLP-ETDLVAQLPQMFQFIN
 .. ...|.|... . |                                                  .   . |...   ..|  ..|. .. .... ..
mvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreal

DgLQAGAVLVHCNAGVSRSPAVVIAYLM-----HKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYE
.  . |.|||||.|||.|. .....||.     . . ..| .|.. .|||||.  ... ..|.|....
e.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal
0036941 (Phosphotyrosine protein) phosphatases II 128-241 1.4e-20 69.2 In-house 99-274 (297) alignment 
Range on Protein: 128-241
Range on HMM: 99-274/297.0
QRNNITHILNVATGVVNVF-------------------------------AKDFTYKNIELLD----------------LPETDLVAQLPQMFQFINDGL
  .|.|.|... . | . .                                .|.|. ..|..|                 |. ..     ....||.  .
weqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvr

-------QAGAVLVHCNAGVSRSPAVVIAYLM--------HKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYEQ
       . | |||||.|||.|| ....|.||        . . ... .|.. .|||||.. ......|.|. ...
kvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeall
subfamily_STYXL1_pd Subfamily STYXL1 133-242 1.2e-20 67.3 In-house 39-152 (157) alignment 
Range on Protein: 133-242
Range on HMM: 39-152/157.0
THILNVATGVVNVFAKD---FTYKNIELLDLPETDLVAQLPQMFQFINDGLQA-GAVLVHCNAGVSRSPAVVIAYLMHKRLLSLGQAFNVVREQRPCVKP
   .||..   ...| .       .|.. | .|.||. .| .. |||..  .   .|||  | |.||| ||.|||||... ..| .|.. ... .. |||
kahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiaylmyskkitlkkaykylkkCkenvkP

NEGFWRQLCNYEQQ
| .|  || ..|.|
nrafveqlseWekq
0051299 (Phosphotyrosine protein) phosphatases II 143-231 5.6e-14 47.7 In-house 175-273 (288) alignment 
Range on Protein: 143-231
Range on HMM: 175-273/288.0
VNVFAKDFTYKNIELLDLPETDLVAQLPQMFQFINDGLQ-----AGAVLVHCNAGVSRSPAVVIAYLM-----HKRLLSLGQAFNVVREQRPCVKPNEG
..   . .|.. .  .. |. .    . ....|...  .      | |.|||.|||.|. ......|.     ... ... .|.. .|||||.. ... 
ldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpe
subfamily_PTPDC1_pd Subfamily PTPDC1 146-224 2.2e-10 35.2 In-house 79-156 (182) alignment 
Range on Protein: 146-224
Range on HMM: 79-156/182.0
FAKDFTYKNIELLDLPETDLvAQLPQMFQFINDGLQAGAVLVHCNAGVSRSPAVVIAYLMHKRLLSLGQAFNVVREQRP
 ... .. |. . |   . |  .. .. . ..  || |.| ||| ||  |   .. .||.... |.  .| ..||..||
meqgiyvynfgwkDygvasl.eriLdivkvvafalqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrp
0046845 (Phosphotyrosine protein) phosphatases II 147-230 2.4e-13 45.6 In-house 167-260 (284) alignment 
Range on Protein: 147-230
Range on HMM: 167-260/284.0
AKDFTYKNIELLDLP--ETDLVAQLPQMFQFINDGLQAGAVLVHCNAGVSRSPAVVIAYLMHKR--------LLSLGQAFNVVREQRPCVKPNE
 . | |...   . |   .||.. | .. .....  . | ..||| |||.|. ......|....         ... .|.. .|||||.   ..
vthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtl
PTPc_DSPc_SM00012 148-213 2.8e-08 29.3 In-house 3-70 (105) alignment 
Range on Protein: 148-213
Range on HMM: 3-70/105.0
KDFTYKNIELLDLPE--TDLVAQLPQMFQFINDGLQAGAVLVHCNAGVSRSPAVVIAYLMHKRLLSLG
|.. |...    .||  ....  | .. .. |.  ... |.||| |||.|.  .| .......| .  
khyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket
DSPc_SM00195 148-227 5.9e-06 21.2 In-house 161-245 (263) alignment 
Range on Protein: 148-227
Range on HMM: 161-245/263.0
KDFTYKNIELLDLP-ETDLVAQLPQMFQFINDGLqAGAVLVHCNAGVSRSPAVVIAYLMHKRLL-----SLGQAFNVVREQRPCVK
. . ||| .  ..| .|. | .| ....  ..    | ..||| |||.|. ..| . .. ..|      .. . .. .|.||| . 
tqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmv
PTPc_SM00194 148-227 5.9e-06 21.2 In-house 161-245 (263) alignment 
Range on Protein: 148-227
Range on HMM: 161-245/263.0
KDFTYKNIELLDLP-ETDLVAQLPQMFQFINDGLqAGAVLVHCNAGVSRSPAVVIAYLMHKRLL-----SLGQAFNVVREQRPCVK
. . ||| .  ..| .|. | .| ....  ..    | ..||| |||.|. ..| . .. ..|      .. . .. .|.||| . 
tqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmv
0047943 (Phosphotyrosine protein) phosphatases II 151-237 2.5e-15 52.1 In-house 151-265 (273) alignment 
Range on Protein: 151-237
Range on HMM: 151-265/273.0
TYKNIELLD----------------LPETDLVAQLPQMFQFINDGL-------QAGAVLVHCNAGVSRSPAVVIAYLM-----HKRLLSLGQAFNVVREQ
|  ..|| .                 |. .  ..| ....||..         . | |.|||.|||.|. ......|.     ... ... .|.. .|.|
tvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsq

RPCVKPNEGFWRQLC
||.. ... ..|.|.
Rpgmvqtpeqyrfly
subfamily_DSP23_pd Subfamily DSP23 151-225 8.8e-08 26.9 In-house 53-127 (148) alignment 
Range on Protein: 151-225
Range on HMM: 53-127/148.0
TYKNIELLDLPETdLVAQLPQMFQFINDG-LQAGAVLVHCNAGVSRSPAVVIAYLMHKRLLSLGQAFNVVREQRPC
|...... |      . |. .. . ...   .. || |||  |  |. ...  ||...| |. ..|   ||..|| 
tlvrlriddyhpp.aleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpg
0050432 (Phosphotyrosine protein) phosphatases II 152-230 1.3e-12 43.1 In-house 204-285 (308) alignment 
Range on Protein: 152-230
Range on HMM: 204-285/308.0
YKNIELLDLPETdlVAQLPQMFQFINDGLQAGAVLVHCNAGVSRSPAVVIAYLM-----HKRLLSLGQAFNVVREQRPCVKPNE
|.| .  . |.   ...| ........ |. | ..|||.|||.|. ......|.     ... ... .|.. .|||||.. ...
ytnWpdhgvPps..peilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp
subfamily_Laforin_pd Subfamily Laforin 152-226 5.8e-09 29.1 In-house 79-154 (183) alignment 
Range on Protein: 152-226
Range on HMM: 79-154/183.0
YKNIELLDLPETDLVAQLPQMFQFINDGLQAG-AVLVHCNAGVSRSPAVVIAYLMHKRLLSLGQAFNVVREQRPCV
|  . . ||     | .|||   ..   |. |  | ||||||| || |.|  .|..    || .    .  .||.|
yiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvv
subfamily_RNGTT_pd Subfamily RNGTT 159-227 2.7e-07 24.5 In-house 90-158 (189) alignment 
Range on Protein: 159-227
Range on HMM: 90-158/189.0
DLPETDLVAQLPQMFQFINDGLQAGAVLVHCNAGVSRSPAVVIAYLMHKRLLSLGQAFNVVREQRPCVK
. ||.. |... .. .  ..      . |||  |  |.  ....||..|.  |. .| .. .. ||   
eaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGi
subfamily_MSG5_pd Subfamily MSG5 162-240 2.6e-12 40.2 In-house 78-157 (165) alignment 
Range on Protein: 162-240
Range on HMM: 78-157/165.0
ETDLVAQLPQMFQFINDGL-QAGAVLVHCNAGVSRSPAVVIAYLMHKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYE
.. .| .|... . |     .   .||||. |.||| ....||.|.   ||| .|.. .. .   ..|. |.  || ..|
dskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewe
Y_phosphatase Protein-tyrosine phosphatase 167-224 6.4e-06 21.1 Pfam-A 153-217 (235) alignment 
Range on Protein: 167-224
Range on HMM: 153-217/235.0
AQLPQMFQFINDGL--QAGAVLVHCNAGVSRSPAVVIAYLMHKRLLS-----LGQAFNVVREQRP
 .| .. . ..     . | |.||| |||.|.  .| . .. ..| .     . |. . .|.|||
kslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRp
Y_phosphatase Protein-tyrosine phosphatase 167-224 6.4e-06 21.1 In-house 153-217 (235) alignment 
Range on Protein: 167-224
Range on HMM: 153-217/235.0
AQLPQMFQFINDGL--QAGAVLVHCNAGVSRSPAVVIAYLMHKRLLS-----LGQAFNVVREQRP
 .| .. . ..     . | |.||| |||.|.  .| . .. ..| .     . |. . .|.|||
kslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRp
0048567 (Phosphotyrosine protein) phosphatases II 179-240 9.5e-06 20.1 In-house 71-135 (157) alignment 
Range on Protein: 179-240
Range on HMM: 71-135/157.0
GLQAGAVLVHCNAGV---SRSPAVVIAYLMHKRLLSLGQAFNVVREQRPCVKPNEGFWRQLCNYE
 |. .|. ||| ||    .|.  .. .||. .  ..  .|.. .|  ||  .|    .  |..|.
elagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyllslyn