Gene PTPDC1 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily PTPDC1
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP017_AA protein Get Run
NvecP017_AA_17-180 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPDC1_pd Subfamily PTPDC1 17-187 8.5e-88 287.6 In-house 12-182 (182) alignment
Range on Protein: 17-187
Range on HMM: 12-182/182.0
EIFAIWITKDILATARPSSEVIKSHCVLEQFKDLGIKSIINLQHPGEHASCGYGLQDSGFSYDPEAFMQVEIFFYNFGWNDYGVRSLESILDMVKVMSFA
 ....|.|.||||.||||.|.|.....|..||. |||..||||..|||||||.||..||||||.||.|. .|..|||||.||||.|||.|||.|||..||
GlystWvtedilalarpsqeaideyklldkfkesgikavinLqekgehasCGagleesGfsYdlealmeqgiyvynfgwkDygvasleriLdivkvvafa

LQEGKTAVHCHAGLGRTGVLICCYFIYSDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDFYKFLSHLWVIF
|||||.|||||||||||||||.||..|..|||||.||.|.|..|||..|||.|.|.||.|..||..|....
lqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvkefalfliplrkvy

0046846 (Phosphotyrosine protein) phosphatases II 18-180 1.2e-36 121.4 In-house 10-172 (176) alignment
Range on Protein: 18-180
Range on HMM: 10-172/176.0
IFAIWITKDILATARPSSEVIK----SHCVLEQFKDLGIKSIINLQHPGEHASCGyglqdsgFSYDPEAFMQVEIFFYNFGWNDYGVRSLESILDMVKVM
 .  .|. ......||              ||..|.|||. ..||. . |.....       . .... .....| .....| |.|| .|| .|.... .
ldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlk.......cpnywpeleklgiqylhlpwpDhgvpdlelllellefi

SFALQEG-KTAVHCHAGLGRTGVLICCYFIYS-DRLTAEEAIHLMRKNRP-KAVQTRGQIECVKDFYKFL
  ||.|| ...|||.||.||||.|...| ...   |..|||..|.|. || .||||..|.. ...|...|
realkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll

0044763 (Phosphotyrosine protein) phosphatases II 18-180 9.9e-33 108.6 In-house 21-170 (178) alignment
Range on Protein: 18-180
Range on HMM: 21-170/178.0
IFAIWITKDILATARPSseviksHCVLEQFKDLGIKSIINLQHPGEHASCGyglqdsgfsYDPEAFMQVEIFFYNFGWNDYGVRS-LESILDMVKVMSFA
| | .|. ...... |.       . ||..|.|||..|.|| .. |.  ..         .||..... .| ...... |.|| . || .|..|. .  |
inaseilpglylgslpp......addlellkelgithivnlteelelgflk.........cdpywpeeagiqylhipipDhgvpdllehflefvefieea

--LQEGKTAVHCHAGLGRTGVLICCYFIYSDRLTAEEAIHLMRKNRPkAVQTRGQIECVKDFYKFL
   ..|...|||.||.||.|.|...| ... .|..||||.|.|. || .|...||.. ...|...|
ldekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrl

0040439 (Phosphotyrosine protein) phosphatases II 18-179 2.4e-28 94.8 In-house 47-244 (249) alignment
Range on Protein: 18-179
Range on HMM: 47-244/249.0
IFAIWITKDILATARPSSEVIKSHcvLEQFKDLGIKSIINLQHPGEH--ASCGYGLQDSGFS----------------------------YDPEAFMQVE
|   .|.....||  | .| ....  ......|||..|..| .. |.    |     ..|.                             ||.| ..   
idgyyikrrfiatqgPlpetvedf..wrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlh

IFFYNFGwnDYGVR-SLESILDMVKVMSFAL----QEGKTAVHCHAGLGRTGVLICCYFI-----YSDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDFY
| ....   |.||  |.|..||... .  ||    ..|...|||.||.||||..|..| .     .  ....|||..|.|. ||.|||. .|.. . .. 
iqytdwp..dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeal

KF
..
le

0043336 (Phosphotyrosine protein) phosphatases II 18-178 7e-27 90.0 In-house 81-274 (278) alignment
Range on Protein: 18-178
Range on HMM: 81-274/278.0
IFAIWITKDILATARPSSEVIKSHcvLEQFKDLGIKSIINLQHPGEHASCG--------------------YGLQDSGFS---------YDPEAfmQVEI
.   .......||  |..| .. .   . ...||...|..|  . |. ...                       .....          .|.|   .   
vdgynvprkfiatqgPlpetvedF..wrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdges..rtvt

FFYNFGWNDYGVR-SLESILDMVKVMSFAL--QEGKTAVHCHAGLGRTGVLICCYFI-----YSDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDFYK
 .. .|| |.||  ||...||..|..  ||  ..|...|||.||.||||..|..| .     .  ....|||.. .|. ||.||||  |.. . .. .
hyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall

0041856 (Phosphotyrosine protein) phosphatases II 19-180 2e-31 104.4 In-house 18-170 (182) alignment
Range on Protein: 19-180
Range on HMM: 18-170/182.0
FAIWITKDILATARPSSEVIKS--------HCVLEQFKDLGIKSIINLQhpgehascgyglqdsGFSYDPEAFMQVEIFFYNFGWNDYGVRSLESILDMV
.  .|.  ... ..|... |           . |...|.|||..|.||                .. |.|| ...  | .....| |.|| .|...||..
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt...............eelywpellerlgiqylylpwpDhgvpdldelldfi

KVMSFalQEGKTAVHCHAGLGRTGVLICCYFIYSDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDFYKFL
. .    ..|...|||.||.||||.|...|.... ....|||..|.|. ||..|.|  |.  . ... .|
eevle..eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallel

0051082 (Phosphotyrosine protein) phosphatases II 20-172 2.1e-25 84.5 In-house 8-144 (151) alignment
Range on Protein: 20-172
Range on HMM: 8-144/151.0
AIWITKDILATARPSSevikshCVLEQFKDLGIKSIINLQHPGEHAscgyglqdsgfsYDPEAFMQVEIFFYNFGWNDYGVRSL----ESILDMVKVMSF
. ..|  ..... |..       .||..|.||||.|.||  . |..            |.|| . . .| .... . |  . .|    ...|......  
fsyvtgglyrsggpla......dflellkelgiktivnlrseeerg............ycpeylpelgievlhipildwpdpglplsfdavleflellld

aLQEGKTAVHCHAGLGRTGVLICCYFIYsDRLTAEEAIHLMRKNRPKAVQTRGQIEC
  ..|...|||.||.||||.|...| ..  ....|||.. .|. || .||.  |. .
.kkngpvlvHCsaGkgRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflf

0043147 (Phosphotyrosine protein) phosphatases II 21-180 3.4e-33 110.2 In-house 16-160 (172) alignment
Range on Protein: 21-180
Range on HMM: 16-160/172.0
IWITKDILATARPSSEVIKSHcvLEQFKDLGIKSIINLQHPgehascgyglqdsgfSYDPEAFMQVEIFFYNFGWNDYGVRSLESILDMVKVMSF---AL
 .|.....||  | .. . ..  ....|.|||. |.||                   |||| ...  | .. ..| |.|| .|| .|.... .       
yyipdrfiatqgplrntladf..wrmlkelgithivnltel...............lydpellerlgiqylylpwpDhgvpllellleflefidellals

QEGKTAVHCHAGLGRTGVLICCYFIYsDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDFYKFL
..|...|||.||.||||.|...| ..  .|..|||..|.|. ||.|||. .|. ....| |.|
pggpvlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekll

0037934 (Phosphotyrosine protein) phosphatases II 21-179 1e-27 92.7 In-house 40-240 (243) alignment
Range on Protein: 21-179
Range on HMM: 40-240/243.0
IWITKDILATARPSSEVIKS--HCVLEQFKDLGIKSIINLQHPGEHASCGYGLQDS---------------------------GFSYDPEAFMQVEIFFY
|..|. . ||  | .| ...     .. ...|||..|..| .. |.  ...    .                              .|.. . .  | ..
iyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyh

NFGWNDYGVRS-LESILDMVKVMS----------FALQEGKTAVHCHAGLGRTGVLICCYFIYSD-RLTAEEAIHLMRKNRPK-AVQTRGQIECVKDFYK
 ..| |.|| .  |..||... .            . ..|...|||.||.||||.||..| ...  ....|||..|.|. ||  ||||..|.. . ....
ylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeall

F
.
e

0038934 (Phosphotyrosine protein) phosphatases II 22-181 3.6e-35 116.8 In-house 15-177 (194) alignment
Range on Protein: 22-181
Range on HMM: 15-177/194.0
WITKDILATARPSSEVIKSHcvLEQFKDLGIKSIINLQH-PGEHASCGYGLQDSGFSYDPEAFMQVEIFFYNFGWNDYGV----RSLESILDMVKVMSFA
.||....|...|.|. . ..  .|... ......... .  ...  . . |  ... |||| |... | .... . |.|.      | ..||.|...  .
iitgrfiafkvPlsgsldky..ieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflne

LQEGKTAVHCHAGLGRTGVLICCYFIYSDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDFYKFLS
 ..|. ||||.|||||||.|...| ||. ...|||||.|.|  ||.|.......| .  .||.| 
dpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykelr

0036282 (Phosphotyrosine protein) phosphatases II 22-181 7.6e-31 102.5 In-house 14-170 (174) alignment
Range on Protein: 22-181
Range on HMM: 14-170/174.0
WITKDILATARPSSevikshcVLEQFKDLGIKSIINLQHPGEHASCG------YglqdsgfsyDPEAFMQVEIFFYNFGWNDYGVRSLESILDMVKVMSF
.||. ..|.. | .        .|..|.|||.....| .. |  ...                ..| . .  | .. ..| |.|| .|. .|..|| .  
yitprliagqgpla.......fwemlkelgittvvmlleekelglykcinywpe.........lredlerlgiqylylpwpDhgvpdlsillefvkfvee

ALQE---GKTAVHCHAGLGRTGVLICCYFIYSDRL-TAEEAIHLMRKNR---PKAVQTRGQIECVKDFYKFLS
||.|   |...|||.||.||||.|...| ..   | ....|..|.|. |   |..||| .|.. . .| |.||
alsedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfeklls

0039614 (Phosphotyrosine protein) phosphatases II 22-178 2.8e-28 94.7 In-house 87-286 (297) alignment
Range on Protein: 22-178
Range on HMM: 87-286/297.0
WI-----------TKDILATARPSSEVIKSHcvLEQFKDLGIKSIINLQHPGEHA--SCGYGLQDSGfSYDPeafM---------QVEIF----------
.|           |....||  |..| ....  .. ....|...|..|  . |.    . |  ...|  |..   .            ..          
YinAsyvdgydlltrkfIatqgPlpetvedF..wrmvweqgvtvivmLtklvelgrkcaqywpeegg.tygd...ftvtllkvehldgytvrtlevtnng

-------FYNFGWNDYGVR-SLESILDMVKVMSFAL----QEGKTAVHCHAGLGRTGVLICCYFI-----YSDRLTAEEAIHLMRKNRPKAVQTRGQIEC
       |  .|| |.||  |||..|.... .  ||    ..|...|||.||.||||..|..| .     .  .....||.. .|. ||.|||| .|.. 
esrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrf

VKDFYK
. |. .
lydall

0042113 (Phosphotyrosine protein) phosphatases II 22-179 6.6e-28 93.2 In-house 49-241 (245) alignment
Range on Protein: 22-179
Range on HMM: 49-241/245.0
WITKDILATARPSSEvikshcV----LEQFKDLGIKSIINLQHPGEHASC----------------------------GYGLQDSGFSYDPEAFMQVEIF
.||. ..||. |..|           ......|||..|..|  . |.  .                            .| .     ..... . .  | 
ritpkfiatqgPlpe......tvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevih

FYNFGWNDYGVRS-LESILDMVKVMSFALQ---EGKTAVHCHAGLGRTGVLICCYFI-----YSDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDFYKF
.. ..| |.|| . ||..||... .  ||.   .|...|||.||.||||..|..| .     .  ....|||.. .|. ||.|||| .|.. . .. ..
yhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle

0045450 (Phosphotyrosine protein) phosphatases II 22-178 1.5e-27 92.5 In-house 104-301 (307) alignment
Range on Protein: 22-178
Range on HMM: 104-301/307.0
WITKDILATARPSSEVIKSHcvLEQFKDLGIKSIINLQHPGEHAS----CGYGLQDSGFSYDP-------------------------EAFMQVEIFFYN
.... ..||  | .| ....  .......|.. |..| .. |...      . . .. . |..                         . ..  ..  . 
dlkrkfIatqgPlpetvedF..wrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfh

F-GWNDYGVR-SLESILDMVKVMSFAL----QEGKTAVHCHAGLGRTGVLICCYFIYSDR--------LTAEEAIHLMRKNRPKAVQTRGQIECVKDFYK
. || |.||  |.|..||... .  ||    ..|...|||.||.||||..|..| ... .        ....||..|.|. ||.|||. .|.. . .. .
ytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall





subfamily_PTEN_pd Subfamily PTEN 22-176 9.9e-13 43.5 In-house 24-175 (184) alignment
Range on Protein: 22-176
Range on HMM: 24-175/184.0
WITKDILATARPSsEVIkSHCVLEQFKDlgIKSIINLQHPGEHAScgYGLQdSGFSYDPEAFmQVEIFFYnfGWNDYGVRSLESILDMVKVMSFALQEGK
.||. |.| . |. | . ...   . .|  .. ... .| ...    | |. |. .|| . | . ..  |  . .|    .|| . ..|. ..  |.| |
yiteniiamgyPa.ekl.ealyRnsled..vvkflekkhkdhyki..ynlr.serkydskkf.dgrvavy..pfdDhnppplelleeivediekwleedk

T---AVHCHAGLGRTGVLICCYFIYSDRLTAE-EAIHLMRKNR---PKAVQTRGQIECVKDF
.   .|||.|| |||||||..|...|  |. . ||..|  ..|    |.|.   |.  |. .
knvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYy

0040438 (Phosphotyrosine protein) phosphatases II 23-185 3.2e-25 84.5 In-house 84-280 (317) alignment
Range on Protein: 23-185
Range on HMM: 84-280/317.0
ITKDILATARPSSEviKSHCVLEQFKDLGIKSIINLQHPGEHA----------------------------SCGYGLQDSGFSY-DPEAFMQVEIFFYnF
... ..||  | ..    .  .. ....|...|..| .. |                                |. |    ... . .   .| .| |  
lkrkfIatqgPlpn..tvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhy.t

GWNDYGVR-SLESILDMVKVMSFALQ--EGKTAVHCHAGLGRTGVLICCYFI-----YSDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDFYKFLSHLWV
|| |.||  |....||... .  ||.  .|...|||.||.||||..|..| .     .  ....|||.. .|. ||.|||| .|.. . |.  ..    .
gWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkl





0045098 (Phosphotyrosine protein) phosphatases II 26-179 3.5e-28 94.2 In-house 65-270 (278) alignment
Range on Protein: 26-179
Range on HMM: 65-270/278.0
DILATARPSSEVIksHCVLEQFKDLGIKSIINLQHPGEHA--SCGYGLQDSG-----------------------------FSYDPEAFMQVEIFFYNF-
  .||. |  . .  .  ......|||..|..| .  | .   |     ..|                             ... .| ... ... ... 
kfIatqgPlpstv..adfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhyl

GWNDYGVRSLE---SILDMVKVMSFAL---------------QEGKTAVHCHAGLGRTGVLICCYFIYSD---RLTAEEAIHLMRKNRPK-AVQTRGQIE
.| |.|| ||.   |.|.... .  ||               ..|...|||.||.||||.|...| ...    .....||.. .|. ||  |||. .|..
pwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyr

CVKDFYKF
 . .|   
flyeflle

subfamily_CDC14_pd Subfamily CDC14 40-169 2.6e-19 64.2 In-house 201-313 (328) alignment
Range on Protein: 40-169
Range on HMM: 201-313/328.0
SHCVLEQFKDLGIKSIINLQHPgehascgyglqdsgfSYDPEAFMQVEIFFYNFGWNDYGVRSLESILDMVKVMSFAlqEGKTAVHCHAGLGRTGVLICC
 . .|| |.. ...... | .                 || . | .  .  ..  . | .. | . .  .....  |  ||. ||||.||||||| || |
PeklleyfrknnvttvvrLnkk...............lYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka..eGaiavhCkaGLGrtGtLiac

YFIYSDRLTAEEAIHLMRKNRPKAVQTRGQ
|...  |.||.|||  .|  ||  | .  |
ylmkhyrftaaeaiawlricrPGsvigpqq

PTEN_1 42-181 2.3e-35 117.2 In-house 58-193 (196) alignment
Range on Protein: 42-181
Range on HMM: 58-193/196.0
CVLEQFKDLGIKSIINLQHPGEHascgyglqdSGFSYDPEAFMQVEIFFYNFGWNDYGVRSLESILDMVKVMSFALQ----EGKTAVHCHAGLGRTGVLI
. |...|  || ...|| .  |.         ||.|||.| |..  . ...|...|.|. ||....|..|..  .|.    ... .|||.|||||.|...
adldnlkedgitlvvnlseeeel.........sgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv

CCYFIYSDRLTAEEAIHLMRKNR-PKAVQTRGQIECVKDFYKFLS
..| .|. .|||.||. |.|. | | |.... | .... |...|.
aayLmykgkltadeAlelvrekRppgapnspsqerlleyfaella

0048076 (Phosphotyrosine protein) phosphatases II 43-180 9.6e-30 98.5 In-house 21-142 (145) alignment
Range on Protein: 43-180
Range on HMM: 21-142/145.0
VLEQFKDLGIKSIINLqhpgehascgyglqdsgfSYDPEAFMQVEIFFYNFGWNDYGVRSL-ESILDMVKVMSFALQEG-KTAVHCHAGLGRTGVLICCY
 ||..|||||. ..||                  ....| . .  | .....| |.|| .| | .|.... .  ||.|| ...|||.||.||||.|...|
dlellkdlgittvlnl..................tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaay

FIYSDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDFYKFL
 ... ....|||..|.|. ||.||.. ||.. ...|.. |
lmlllgvsleealelvrsqrpgavpnpgqlrflyefelel

0049260 (Phosphotyrosine protein) phosphatases II 43-180 6.8e-29 95.9 In-house 25-149 (152) alignment
Range on Protein: 43-180
Range on HMM: 25-149/152.0
VLEQFKDLGIKSIINLQHPGEHAS--CGYGLqdsgfsydpeafmqveiFFYNFGWNDYGVRSLESILDMVKVMS---FALQEGKTAVHCHAGLGRTGVLI
.....|.|||. |..|  . | .   | ..                   .... | |.|| .|. .|...  .       ..|...|||.||.||||.|.
fwrmlkelgittivmltellelgklkceqyi.................qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlv

CCYFIYsDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDFYKFL
..| ..  ....|||. |.|. ||.||.. ||.. ...|.|.|
aaylml.lgvsleeavalvrekRpgavpnpgqlrflyefekll

0048179 (Phosphotyrosine protein) phosphatases II 44-179 1.1e-28 95.1 In-house 22-143 (144) alignment
Range on Protein: 44-179
Range on HMM: 22-143/144.0
LEQFKDLGIKSIINLQHPGEHASCGYGlqdsgfsydpeafmqvEIFFYNFGWNDYGVRSL-ESILDMVKVMSFALQ-EGKTAVHCHAGLGRTGVLICCYF
||..|.|||. .|||... |.....                   | .....| |.|| .| | .|.... .  ||. .|...|||.||.||||.|...| 
lellkklgittvinlteeyepeflere................giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaayl

IYSDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDFYKF
..  .|..|||..|.|. || ||...||.. .....|.
mkklglsleealalvrsrrpgavpnpgqlrfLleyekl

0051429 (Phosphotyrosine protein) phosphatases II 44-180 1.5e-23 79.3 In-house 38-224 (272) alignment
Range on Protein: 44-180
Range on HMM: 38-224/272.0
LEQFKDLGIKSIINLQHPGEHASCGYGLQDSGFSYDPEAFMQVEIFF-----------------------------------------YNFGWNDYGVRS
....|.||||.|..| .. |...... .   |. |    ..  . ..                                         .  .| |.|| .
fwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpq

--LESILDMVKVmsfalqEGKTAVHCHAGLGRTGVLICCYFIYsDRLT--------------AEEAIHLMRKNRPKAVQTRGQIECVKDFYKFL
  | ..|...        .|.  |||.|| .|||...... ..  ...              .|||.. .|. ||.|||| .|.... .... |
eallellellld......ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallel

DSPc Dual specificity phosphatase, catalytic domain 44-176 5.5e-16 53.6 Pfam-A 11-130 (133) alignment
Range on Protein: 44-176
Range on HMM: 11-130/133.0
LEQFKDLGIKSIINLQHPGEHAscgyglqdsgFSYDPEAFMQVEIFfYNFGWNDYGVRSLESILDMVKvmSFALQEGKTAVHCHAGLGRTGVLICCYFIY
|.. ..|||. .||...  ...          ... .. . ...|   .  ...  .. ||.. ....  ... ...| .||| ||. |.. ||..| ..
lalleklgitlvinvtkevpnn..........naikkseieylrip.vedetetkiskeleeavefie..kaeqkgkkvlVHCqaGisRSatliiaYlmk

SDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDF
...|...||.......|.| ... |..  . ..
tknlslneAyefvkerrskispnagflrqLley

DSPc Dual specificity phosphatase, catalytic domain 44-176 5.5e-16 53.6 In-house 11-130 (133) alignment
Range on Protein: 44-176
Range on HMM: 11-130/133.0
LEQFKDLGIKSIINLQHPGEHAscgyglqdsgFSYDPEAFMQVEIFfYNFGWNDYGVRSLESILDMVKvmSFALQEGKTAVHCHAGLGRTGVLICCYFIY
|.. ..|||. .||...  ...          ... .. . ...|   .  ...  .. ||.. ....  ... ...| .||| ||. |.. ||..| ..
lalleklgitlvinvtkevpnn..........naikkseieylrip.vedetetkiskeleeavefie..kaeqkgkkvlVHCqaGisRSatliiaYlmk

SDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDF
...|...||.......|.| ... |..  . ..
tknlslneAyefvkerrskispnagflrqLley

PTPc_motif_SM00404 44-177 8.9e-15 49.8 In-house 20-138 (140) alignment
Range on Protein: 44-177
Range on HMM: 20-138/140.0
LEQFKDLGIKSIINLQHPGEHAscgyglqdsgfsYDPEAFMQVEIFfYNFGWNDYGVRSLESILDMVKVMsfALQEGKTAVHCHAGLGRTGVLICCYFIY
... | |||. .||..   .              .  . |  ..|   .   .|  .. |...||... .  . ..||  ||| ||. |.. ||..| ..
pallkklgithvinvteevslt............kensgfqilqip.lddnekdklskyldkvldfiena..ekkggkvlVHCqaGvSRSatliiaYlmr

SDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDFY
.. |...||.......||.  .. . .. . ...
yrqlslaeayefvkerRpiispnlnfvrqLieye

0049772 (Phosphotyrosine protein) phosphatases II 59-178 7.7e-22 73.8 In-house 167-271 (314) alignment
Range on Protein: 59-178
Range on HMM: 167-271/314.0
QhpgehascgyglqdsGFSYDPEAFMQVEIFFYNFGWNDYGVRSLESILDMVKVMSFALQEGKTAVHCHAGLGRTGV-LICCYFIYSDRLTAEEAIHLMR
.               .  |||| | .  | .... . |... .|| ........  | ..|...|||.|| ||||. ....| ..  ....|||.. .|
k...............eelydpelferlgikylripvpDgsaplledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvr

KNRPkAVQTRGQIECVKDFYK
. || .   .|.||  .....
lkRp.inpnpgfieqleqyef

subfamily_PTPN6_pd Subfamily PTPN6 60-173 1.5e-07 25.7 In-house 160-289 (306) alignment
Range on Protein: 60-173
Range on HMM: 160-289/306.0
HPGEHASCGYGLQDSGFSYDPEAFMQVEIFFYNF-GWNDYGVRSLES-ILDM---VKVMSFAL---QEGKTAVHCHAGLGRTGVLICCYFIYS----D--
.  |..   | | .   |   ..  . |.| |.|  | | ||..  . .||.   |.  .  |   ..| . ||| ||.|||| .|    . .       
nvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgl

--RLTAEEAIHLMRKNRPKAVQTRGQIECV
   .  .......|. |   |||  |   |
dadidiqklvksvreqrsglvqteqqykfv

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 69-171 7e-07 24.0 In-house 132-245 (284) alignment
Range on Protein: 69-171
Range on HMM: 132-245/284.0
YGLQDSGFSYDPEAFMQVEIFFYNF-GWNDYGVRSLES-ILDMVKVMSFA---LQ-EGKTAVHCHAGLGRTGVLICCYFIYsDRLTAEEAIHL------M
| ..|   | | .   . .|  . | || |.||    | .. .|| ..      . . .  ||| || ||||| |.   .  ||.  |. . .      .
yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvll.drmkeekqvdvynfvrdl

RKNRPKAVQTRGQIE
|..|.. ||   |  
rqqrntlvqdlvqyk

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 69-171 7.7e-07 23.7 In-house 168-281 (319) alignment
Range on Protein: 69-171
Range on HMM: 168-281/319.0
YGLQDSGFSYDPEAFMQVEIFFYNF-GWNDYGVRSLES-ILDMVKVMSFA---LQ-EGKTAVHCHAGLGRTGVLICCYFIYsDRLTAEEAI------HLM
| ..|   | | .   . .|  . | || |.||    | .. .|| ..      . . .  ||| || ||||| |    .  ||.  |. .      . .
yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvll.drmkeekqvdvynfvrdl

RKNRPKAVQTRGQIE
|..|.. ||   |  
rqqrntlvqdlvqyk

subfamily_VSP_pd Subfamily VSP 76-160 6.6e-09 30.0 In-house 85-170 (212) alignment
Range on Protein: 76-160
Range on HMM: 85-170/212.0
FSYDPEAFMQVeifFYNFGWNDYGVRSLESILDMVKVMSFALQEGK---TAVHCHAGLGRTGVLICCYFIYSDRL-TAEEAIHLMRKNR
 .||.. | .      .   .|. | .|| .| . | .   |.. .    |.||  | |||| ..|.....|. . ||.|... . . |
raydekyfnnr...vkriliddhnvpkleellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerr

0048567 (Phosphotyrosine protein) phosphatases II 77-180 5.6e-18 59.7 In-house 27-138 (157) alignment
Range on Protein: 77-180
Range on HMM: 27-138/157.0
SYDPEAFMQVEIFFYNFGWNDYGVRSLESILDMVKVMSFAL-----QEGKTAVHCHAGL---GRTGVLICCYFIYSDRLTAEEAIHLMRKNRPKAVQTRG
 |..  |   . ..|.  . |.|  .|  . . ....   |     .... ||||.|||   |||..||.|| |.  ..|.||||...|  ||. |  | 
lynalyFsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrd

QIECVKDFYKFL
.   . ...  |
asyllslynltl

subfamily_PRL_pd Subfamily PRL 77-176 1.4e-10 35.4 In-house 45-145 (151) alignment
Range on Protein: 77-176
Range on HMM: 45-145/151.0
SYDPEAFMQVEIFFYNFGWNDYGVRSLESILDMVKVMSFALQE---GKTAVHCHAGLGRTGVLICCYFIYsDRLTAEEAIHLMRKNRPKAVQTRgQIECV
.|| |.. . .|   .. ..| .| . | . . ....  . .|      |||| |||||. ||..  .|  . .. |.|....|..|  |. .. |.. .
tydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalalie.aGmkyedavefirekrrgainsk.qlkfl

KDF
...
eky

subfamily_DSP3_pd Subfamily DSP3 77-161 2.3e-09 31.1 In-house 52-139 (162) alignment
Range on Protein: 77-161
Range on HMM: 52-139/162.0
SYDPEAFMQVEIFFYNFGWNDYGVRSLESILDM-VKVMSFALQE--GKTAVHCHAGLGRTGVLICCYFIYSDRLTAEEAIHLMRKNRP
  ..| . ..|| .. .  .|     |.   .  .| .  ||..  ||  |||..|. |  .|.  | . . ..|. |||. .||.| 
dtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkRe

subfamily_Tensin_pd Subfamily Tensin 77-152 1.3e-07 24.3 In-house 62-137 (189) alignment
Range on Protein: 77-152
Range on HMM: 62-137/189.0
SYDPEAFMQvEifFYNFGWNDYGVRSLESILDMVKVMSFALQEGKT---AVHCHAGLGRTGVLICCYFIYSDRLTAEEA
.|| . . . .    .||| |    ||| .  ..| .   |..      .|||. | ||.||.. .|  ||.  ....|
rydisklnk.k..vldfGWPdllaPsleklcsicksldsWlkadpqnvvvvhckGgkgrigvvvsaymkyskisasada

subfamily_PTPMT1_pd Subfamily PTPMT1 81-181 2.7e-15 51.2 In-house 67-169 (171) alignment
Range on Protein: 81-181
Range on HMM: 67-169/171.0
EAFMQVEIFFYNFGWNDYG-VRSLESILDMVKVMSFALQEGKT-AVHCHAGLGRTGVLICCYFIYSDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDFYK
| . .. . ....   |.    .||.... |....   ..||.  |||.|| ||.. |. || .....|. |||.. ..| |..    . | . .. ...
eewkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyee

FLS
.| 
kll

subfamily_CDKN3_pd Subfamily CDKN3 83-180 4.2e-12 40.1 In-house 95-195 (202) alignment
Range on Protein: 83-180
Range on HMM: 95-195/202.0
FMQVEIFFYNFGWNDYGVRSLESILDMVKVMSFALQEG-KTAVHCHAGLGRTGVLICCYFIY-SDRLTAEEAIHLMRKNR-PKAVQTRGQIECVKDFYKF
. |. .  . .   | .| .  | |.... .  .|... || |||. ||||. ..| | ..| .| .  ..||  .|. .  .|.||  | . ...| . 
yqqaglivhhypiadglvpdiasclkileelrinlkayrktlvhcygglgrsslviaclllylddtiepkdaidklrdlkgsraiqtvkqynylsefrdk

L
|
l

CDKN3 Cyclin-dependent kinase inhibitor 3 (CDKN3) 83-153 4.1e-07 21.3 Pfam-A 96-168 (168) alignment
Range on Protein: 83-153
Range on HMM: 96-168/168.0
FMQVEIFFYNFGWNDYGVRSLESILDMVKVMSFALQE-GKTAVHCHAGLGRTGVLICCYFIY-SDRLTAEEAI
. |. |  .    .| |   . | |.... .. .|..  || .||. ||||. .. .| ..| || .. |.||
yqqygivthhhpiadggtpdiascleimeelatclknyrktlihcygglgrsclvaaclllylsdsispeqai

CDKN3 Cyclin-dependent kinase inhibitor 3 (CDKN3) 83-153 4.1e-07 21.3 In-house 96-168 (168) alignment
Range on Protein: 83-153
Range on HMM: 96-168/168.0
FMQVEIFFYNFGWNDYGVRSLESILDMVKVMSFALQE-GKTAVHCHAGLGRTGVLICCYFIY-SDRLTAEEAI
. |. |  .    .| |   . | |.... .. .|..  || .||. ||||. .. .| ..| || .. |.||
yqqygivthhhpiadggtpdiascleimeelatclknyrktlihcygglgrsclvaaclllylsdsispeqai

subfamily_Ptp69D_pd Subfamily Ptp69D 84-160 2.7e-08 28.3 In-house 182-259 (307) alignment
Range on Protein: 84-160
Range on HMM: 182-259/307.0
MQVEIFFYNfGWNDYGV-RSLESILDMVKVM--SFALQEGKTAVHCHAGLGRTGVLICCYFIYsDRLTAEEAIHLMRKNR
 .|  . |. ||.|. | .. ...|.... .     |...   ||| || ||.|....   .  ..| ||. ....   .
rkvvqyhyt.gWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsll.qqlkaedkvdifetvk

Y_phosphatase Protein-tyrosine phosphatase 85-173 4.8e-12 41.2 Pfam-A 134-229 (235) alignment
Range on Protein: 85-173
Range on HMM: 134-229/235.0
QVEIFFYNfGWNDYGVR-SLESILDMVKVMSFAL--QEGKTAVHCHAGLGRTGVLICCYFIYSDRLT-----AEEAIHLMRKNRPKAVQTRGQIECV
.|. . |. .|.|.||  | .|.||... .      ..|.. ||| || ||||....  .. .   .       ...  .||.||..||.  | . .
evkqlhyt.nWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYifl

Y_phosphatase Protein-tyrosine phosphatase 85-173 4.8e-12 41.2 In-house 134-229 (235) alignment
Range on Protein: 85-173
Range on HMM: 134-229/235.0
QVEIFFYNfGWNDYGVR-SLESILDMVKVMSFAL--QEGKTAVHCHAGLGRTGVLICCYFIYSDRLT-----AEEAIHLMRKNRPKAVQTRGQIECV
.|. . |. .|.|.||  | .|.||... .      ..|.. ||| || ||||....  .. .   .       ...  .||.||..||.  | . .
evkqlhyt.nWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYifl

subfamily_PTPRD_pd Subfamily PTPRD 85-169 4.7e-09 30.4 In-house 178-269 (564) alignment
Range on Protein: 85-169
Range on HMM: 178-269/564.0
QVEIFFYnFGWNDYGVR-SLESILDMVKVMSF--ALQEGKTAVHCHAGLGRTGVLICCYfIYSDRLTAEEA------IHLMRKNRPKAVQTRGQ
.|. | .   | | ||  | .|.||... ..     ..| . ||| || ||||. |    .  .|...|.       ....||.|.  |||. |
eVrqFhF.tsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfivid.amlerikeektvDiyqyvkalrkqRnamVqteeQ

subfamily_PTPRK_pd Subfamily PTPRK 85-175 2.2e-08 28.3 In-house 174-271 (314) alignment
Range on Protein: 85-175
Range on HMM: 174-271/314.0
QVEIFFYnFGWNDYGVR-SLESILDMVKVMSFA--LQEGKTAVHCHAGLGRTGVLICCYFIySDRLTAEE------AIHLMRKNRPKAVQTRGQIECVKD
.|  | .  || |..|  | ...|..|. .      ..|.. ||| || ||||. | .  .  | .  |.      |.. .|....  |.|  |   . |
evrqfqf.lgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidiv.ldmieregvvdvfnavktlrsrkvnmveteeqykfiyd





0051299 (Phosphotyrosine protein) phosphatases II 86-173 1.8e-19 65.7 In-house 183-278 (288) alignment
Range on Protein: 86-173
Range on HMM: 183-278/288.0
VEIFFYNFGWNDYGVRS-LESILDMVKVMSFA--LQEGKTAVHCHAGLGRTGVLICCYFI-----YSDRLTAEEAIHLMRKNRPKAVQTRGQIECV
  . |. ..| |.|| . .|..||... .  |   ..| ..|||.||.||||..|... .     .  .....||.. .|. || .|||  |.. |
tvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfv

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 86-173 1.1e-08 29.5 In-house 175-271 (288) alignment
Range on Protein: 86-173
Range on HMM: 175-271/288.0
VEIFFYNF-GWNDYGV-RSLESILDMVKVMSFALQE--GKTAVHCHAGLGRTGVLICCYFIY-----SDRLTAEEAIHLMRKNRPKAVQTRGQIECV
.||  |.. .| | || .| . .|.... .  | |.  |.  ||| ||.||||. |    .      .| .   .... .||.|.  |||  | | .
leitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefi

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 86-172 2.4e-08 28.4 In-house 180-274 (319) alignment
Range on Protein: 86-172
Range on HMM: 180-274/319.0
VEIFFYNfGWNDYGV-RSLESILDMVKVMSFALQE---GKTAVHCHAGLGRTGVLIcCYFIYSDRLTAEEAIHL------MRKNRPKAVQTRGQIEC
|  | |.  | | .| ... |.||..| .  . ..   |   ||| || ||||  |   ..  .|.  |... .      .|  |.  ||.  | . 
vkhfqyt.eWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfi.vldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkf

subfamily_PTPN12_pd Subfamily PTPN12 87-173 1.4e-11 38.8 In-house 173-269 (290) alignment
Range on Protein: 87-173
Range on HMM: 173-269/290.0
EIFFYNfGWNDYGV-RSLESILDMVKVMSFALQEGK--TAVHCHAGLGRTGVLICCYFIYSDrLTAE---------EAIHLMRKNRPKAVQTRGQIECV
. | |.  | | || .| .|.|.... .    .. .   .||| || ||||..|   ....  | ||         . .  .||.|. .|||. | | |
yqfhYt.aWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrel.lkaekipeeldvfdlvlelrkqraalvqtkeqyelv

subfamily_PTPN13_pd Subfamily PTPN13 87-174 9.1e-11 36.5 In-house 167-263 (273) alignment
Range on Protein: 87-174
Range on HMM: 167-263/273.0
EIFFYNF-GWNDYGVRS-LESILDMVKVMS-FALQEGKTAVHCHAGLGRTGVLICCYFIYS-----DRLTAEEAIHLMRKNRPKAVQTRGQ-IECVK
|.   ||  | |.|| |  ...| .|. .  .. ..|  .||| ||.||.|.||. . .         .  .| .. .|. |   |||. | | . |
evahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvyk

0047943 (Phosphotyrosine protein) phosphatases II 88-173 6.1e-21 70.5 In-house 169-264 (273) alignment
Range on Protein: 88-173
Range on HMM: 169-264/273.0
IFFYNFGWNDYGVR-SLESILDMVKVMSFALQ----EGKTAVHCHAGLGRTGVLICCYFI-----YSDRLTAEEAIHLMRKNRPKAVQTRGQIECV
. |. .|| |.||  ||||.|......  ||.    .|...|||.||.||||..|... .     .  .....||..|.|. || .|||  |.. .
thfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl

0046845 (Phosphotyrosine protein) phosphatases II 88-177 1.3e-20 69.4 In-house 168-270 (284) alignment
Range on Protein: 88-177
Range on HMM: 168-270/284.0
IFFYNFGWNDYGVR-SLESILDMVKVMSFALQ----EGKTAVHCHAGLGRTGVLICCYFIYSD--------RLTAEEAIHLMRKNRPKAVQTRGQIECVK
. |. ..| |.||  |.|..|.... .  .|.    .|...|||.||.||||..|... ...         .....||.. .|. || .|||  |.. | 
thfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvy

DFY
.. 
eal

subfamily_DSP23_pd Subfamily DSP23 88-180 4.6e-18 60.3 In-house 52-145 (148) alignment
Range on Protein: 88-180
Range on HMM: 52-145/148.0
IFFYNFGWNDYGVRSLESILDMVKVMSFALQEGK-TAVHCHAGLGRTGVLICCYFIYSDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDFYKFL
. ..... .||   .|| . ..|.|.  | . ..  .|||  | |||| .. ||..   .|.| |||  .|. || .|.|  | . |.|.  |.
ltlvrlriddyhppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsvetveqeklvrdyetfi

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 88-175 2.5e-10 34.9 In-house 179-274 (318) alignment
Range on Protein: 88-175
Range on HMM: 179-274/318.0
IFFYNfGWNDYGVR-SLESILDMVKVMSFAL---QEGKTAVHCHAGLGRTGVLICCYfIYSDRLTAEEAI------HLMRKNRPKAVQTRGQIECVKD
 . |   | | ||  |  |.||.|.  | |    ..| ..||| || ||||| |    |  .|. ||. .      . .|..|.  |||. | | . |
qyhyt.sWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavd.illerikaealvDvfqtvkqlreqrnlmvqtedqyefiyd

subfamily_PTPRB_pd Subfamily PTPRB 88-171 1.5e-09 32.3 In-house 181-275 (293) alignment
Range on Protein: 88-171
Range on HMM: 181-275/293.0
IFFYNF-GWNDYGVR-SLESILDMVKVMSFAL----QEGKTAVHCHAGLGRTGVLICCYFIY-----SDRLTAEEAIHLMRKNRPKAVQTRGQIE
.  |.|  | |.||  . ...||.|. .  |.    ... . ||| ||.||||..|.   .      .| .     .. .|..|   |||  |  
vrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYi

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 88-173 1.3e-08 29.2 In-house 156-256 (270) alignment
Range on Protein: 88-173
Range on HMM: 156-256/270.0
IFFYNfGWNDYGVRSLES-------ILDMVKVMSFALQEG----KTAVHCHAGLGRTGVLICCYFI-----YSDRLTAEEAIHLMRKNRPKAVQTRGQIE
 |.||  |.| || . |        .| |.. .    .|      . ||| ||.||||.||   ..      . ..   . |. .||.|.. ||.  |.|
Hfwyn.tWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqye

CV
 .
fl

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 88-173 1.8e-06 22.2 In-house 165-260 (274) alignment
Range on Protein: 88-173
Range on HMM: 165-260/274.0
IFFYNfGWNDYGV-RSLESILDMVKVMSFALQEGK-----TAVHCHAGLGRTGVLICCYfIYSDRLTAEEAIHLM------RKNRPKAVQTRGQIECV
 ..|   | |  . .. ...||.|. .. . .| .     . ||| ||.||||. |    |   .| .|. . ..      | .|   |||. | | .
hywyt.dWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiais.iavrqlreeivvdvlkivcnlrldrGGmvqtseqyeli

0050432 (Phosphotyrosine protein) phosphatases II 89-173 5.1e-21 70.7 In-house 201-291 (308) alignment
Range on Protein: 89-173
Range on HMM: 201-291/308.0
FFYNFGWNDYGVRS-LESILDMVKVMSFALQEGKTAVHCHAGLGRTGVLICCYFI-----YSDRLTAEEAIHLMRKNRPKAVQTRGQIECV
 |.  .| |.|| . .|..||... .   |..|...|||.||.||||..|... .     .  .....||.. .|. || .|||  | . .
hfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylfl

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 89-171 4e-06 20.8 In-house 184-271 (301) alignment
Range on Protein: 89-171
Range on HMM: 184-271/301.0
FFYNF-GWNDYGVRslESILDMVKVMSFALQEGK-TAVHCHAGLGRTGVLICCYFIYSD-----RLTAEEAIHLMRKNRPKAVQTRGQIE
  |..  | |.||   .|  .. ..| .. .  |   ||| ||.||.  .|   .. ..     ..   ||.. .|..| ..|||. |. 
thyqysewtdrgvP..kshaelfdlmelvkksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqly

0036941 (Phosphotyrosine protein) phosphatases II 90-181 3e-20 68.2 In-house 173-277 (297) alignment
Range on Protein: 90-181
Range on HMM: 173-277/297.0
FYNFGWNDYGVRS-LESILDMVKVMSFAL----QEGKTAVHCHAGLGRTGVLICCYFI--------YSDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDF
|. .|| |.|| .  .|.||... .  .|    ..|.. |||.||.||.|..|... .        .  ...  ||.. .|. || |||| .| . . ..
fhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyea

YKFLS
  .| 
llell

PTPc_DSPc_SM00012 90-173 6e-14 47.5 In-house 5-99 (105) alignment
Range on Protein: 90-173
Range on HMM: 5-99/105.0
FYNFGWNDYGVRS-LESILDMVKVMSFALQE----GKTAVHCHAGLGRTGVLICCYFIYSDRLTA------EEAIHLMRKNRPKAVQTRGQIECV
..  || | || .  .|||.... .    ..    . . |||.|| ||||.... . ....  .       .. .. .|| ||..|||  |   .
yhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfl

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 90-173 3.8e-09 31.1 In-house 183-280 (325) alignment
Range on Protein: 90-173
Range on HMM: 183-280/325.0
FYNFGWNDYGVR----SLESILDMVKVMSFALQE-----GKTAVHCHAGLGRTGVLICCYFIYS-----DRLTAEEAIHLMRKNRPKAVQTRGQIECV
|   .|.| ||.    .| |||..|| .|  ..      .   ||| ||.|||||.|. | .        |.   . .. .||.||. |.|  |   .
fqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyili

subfamily_PTPRA_pd Subfamily PTPRA 90-207 8.8e-09 29.7 In-house 196-315 (330) alignment
Range on Protein: 90-207
Range on HMM: 196-315/330.0
FYNFGWNDYGVRSL-ESILDMVKV-MSFALQE-GKTAVHCHAGLGRTGVLICCYFIYsDRLTAEE------AIHLMRKNRPKAVQTRGQIECVkdfYKFL
|.  .| | || .    .|...|   .   |. |   ||| || |||| .|    .  .|. ||.      ... .|..||. |||  | | .   || |
fhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavl.ervkaerkvdvfefvkrlrlqrpqmvqtdeqyefi...ykvl

SHLWVIfpsSHSEAKQFTLENYLKKQR
 . ..      .| . ..||..|.|  
leyyly...gdteldvsslekhlqkly

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 90-171 1.7e-08 29.1 In-house 190-280 (298) alignment
Range on Protein: 90-171
Range on HMM: 190-280/298.0
FYNFGWNDYGVR-SLESILDMVK-VMSFALQEG--KTAVHCHAGLGRTGVLICCYFIYsDRLTAEE------AIHLMRKNRPKAVQTRGQIE
.  . | | ||    .|.||... |     | |     |.| || ||.|  |  . .  .|. .|.      ... .||.||.||||. |  
lhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvl.ervkkeqvvDvfqvvkvlRkkrpgavqteeqYv

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 90-174 5.1e-08 26.7 In-house 94-187 (440) alignment
Range on Protein: 90-174
Range on HMM: 94-187/440.0
FYNFGWNDYGVRSLE-SILDMVKVMSFA---LQEGKTAVHCHAGLGRTGVLICCYFIY-----SDRLTAEEAIHLMRKNRPKAVQTRGQIECVK
..  || | ||  .   .| |.. .. .     .|   ||| || |||||.|.   |      ||..     |  ||.|||. |||  |   |.
yhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 91-172 2.8e-07 25.0 In-house 143-233 (250) alignment
Range on Protein: 91-172
Range on HMM: 143-233/250.0
YNFGWNDYGVR-SLESILDMVKVMSFALQE---GKTAVHCHAGLGRTGVLICCYFIYsDRLTAE------EAIHLMRKNRPKAVQTRGQIEC
  . | | ||    ...|...| .    |.   .   |.| || ||.|  |  . .  .||  |      . |. .||.||.||... |   
hfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl.erlkkekvvdvfkvikvlrkdrphavesleqyvf

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 91-173 3.5e-07 24.4 In-house 179-269 (315) alignment
Range on Protein: 91-173
Range on HMM: 179-269/315.0
YNFGWNDYGVR-SLESILDMVKVMS--FALQEGKTAVHCHAGLGRTGVLICCYFIYS-----DRLTAEEAIHLMRKNRPKAVQTRGQIECV
   .| | ||   . |.| ..| .      .|    ||| || |||||.|    . .     . .   . .. .|..||. |||. .   .
qftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafi

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 92-174 4.7e-07 24.0 In-house 169-259 (283) alignment
Range on Protein: 92-174
Range on HMM: 169-259/283.0
NFGWNDYGVRS-LESILDMVKVMSFALQE--GKTAVHCHAGLGRTGVLICCYFIYSDRLTA-----EEAIHLMRKNRPKAVQTRGQIECVK
  .| .||  . ..|.. . ||.|   ..  |   ||| .| |||.|.|       | ||       . .. ||..|. ||||..|   | 
vidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvh

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 93-167 1.1e-06 22.6 In-house 194-273 (305) alignment
Range on Protein: 93-167
Range on HMM: 194-273/305.0
FGWNDYGVRSLE-SILDMVKVMsfALQEGKTAVHCHAGLGRTGVLICCYFIYSDRLtAEEAI-------HLMRKNRPKAVQTR
  | | || . . .||....        | ..||| ||.|||| ..   .|  . | | . |         .|..| ...|| 
idwpdrgvpaadlailelleka..rpskgpivvhcsagigrtgsvvmleyildqll.agqiiedtdkilqkireqrnnsiqtd

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 93-172 3.9e-06 20.2 In-house 180-267 (515) alignment
Range on Protein: 93-172
Range on HMM: 180-267/515.0
FGWNDYGVRS-LESILDMVKVMSFALQ--EGKTAVHCHAGLGRTGVLICCYFIYSDRLTAE-----EAIHLMRKNRPKAVQTRGQIEC
 .| | ||     |.| ..| .    .  .    .|| || |||||.|    . ..  |..     . .. .|..||. |||. |   
teWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyaf

DSPc_SM00195 94-173 6.2e-12 40.7 In-house 167-254 (263) alignment
Range on Protein: 94-173
Range on HMM: 167-254/263.0
GWNDYGVR-SLESILDMVKVMSFALQ--EGKTAVHCHAGLGRTGVLICCYFIYSDR-----LTAEEAIHLMRKNRPKAVQTRGQIECV
.|.| ||  | .|.|......    .  .| . |||.||.||||....  .|.|       .  .| .  .||.||..|||. |   .
nWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfi

PTPc_SM00194 94-173 6.2e-12 40.7 In-house 167-254 (263) alignment
Range on Protein: 94-173
Range on HMM: 167-254/263.0
GWNDYGVR-SLESILDMVKVMSFALQ--EGKTAVHCHAGLGRTGVLICCYFIYSDR-----LTAEEAIHLMRKNRPKAVQTRGQIECV
.|.| ||  | .|.|......    .  .| . |||.||.||||....  .|.|       .  .| .  .||.||..|||. |   .
nWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfi

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 94-175 4.1e-09 31.0 In-house 187-277 (305) alignment
Range on Protein: 94-175
Range on HMM: 187-277/305.0
GWNDYGV-RSLESILDMVKVMSFALQEGKT---AVHCHAGLGRTGVLICCYfIYSDRLTAEEAIHL------MRKNRPKAVQTRGQIECVKD
 | | || ..  |.|...| .  . ...|     ||| ||.||||| |.   |  .|| .|| . .      .|..|.|.|||  |   . |
dWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavd.ialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhd

subfamily_PTPN3_pd Subfamily PTPN3 94-173 3.4e-07 24.5 In-house 180-267 (280) alignment
Range on Protein: 94-173
Range on HMM: 180-267/280.0
GWNDYGVRS-LESILDMVKVMSFAL--QEGKTAVHCHAGLGRTGVLIC-----CYFIYSDRLTAEEAIHLMRKNRPKAVQTRGQIECV
 | | || .  ...|..|. .  .   .|  . ||| ||.|||||||      .    .. .   . .. ||  |   ||| .| . |
aWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfv

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 94-173 6.5e-06 20.5 In-house 179-268 (281) alignment
Range on Protein: 94-173
Range on HMM: 179-268/281.0
GWNDYGVR-SLESILDMVKVM-SFALQEG--KTAVHCHAGLGRTGVLICCYFIYS------DRLTAEEAIHLMRKNRPKAVQTRGQIECV
 | | ||  . . .|.  | . ..  ..      .|| || ||||. |    . .       .|  .. .. .||.|   |||  | | |
aWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefv

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 95-176 1.1e-06 22.9 In-house 185-274 (315) alignment
Range on Protein: 95-176
Range on HMM: 185-274/315.0
WNDYGVR-SLESILDMVK-VMSFAL-QEGKTAVHCHAGLGRTGVLICCYFIYsDRLTAEEAIH------LMRKNRPKAVQTRGQIECVKDF
| | ||  .  ....... |. .   . |   |||.|| |||| .|.   .  |.. ||.||        .|.|| |.||.  | . . | 
wpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavl.dqaeaenaidvynfitgvrqnrikmvqvaeqyqfiyda

subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 100-178 2.3e-07 24.3 In-house 72-150 (154) alignment
Range on Protein: 100-178
Range on HMM: 72-150/154.0
VRSLESILDMVKVMSFALQEGKTAVHCHAGLGRTGVLICCYFIYSDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDFYK
...|.  .....    .....|  ||...|. |.  |.  |.. . ...  .|. |... |..    .| .. .. | |
iekldkafefiddaiggvennkvlvhsdkGvsrsaallisylmdklkislslalellkdsryiikPnqGflkqleifek

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 103-173 2.2e-08 28.6 In-house 201-276 (297) alignment
Range on Protein: 103-173
Range on HMM: 201-276/297.0
LESILDMVKVMSFALQEGKTAVHCHAGLGRTGVLICCYFIYSDRLTAEE-----AIHLMRKNRPKAVQTRGQIECV
|  ... |.      .||   ||| ||.||||||.    . ..    .|      .. .|..||. |||. | . |
llklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfv

subfamily_Laforin_pd Subfamily Laforin 108-178 7.7e-06 18.9 In-house 98-170 (183) alignment
Range on Protein: 108-178
Range on HMM: 98-170/183.0
DMVKVMSFALQEGK-TAVHCHAGLGRTGVLICCYFIYSDRLTAEEAIHLMRKNRPKA-VQTRGQIECVKDFYK
. | ..   |..|.   ||| ||.||.  ..| .. |    .     . .  .|| . .. .  | . |||..
qavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvvyideealiraekdfiq

subfamily_DSP14_pd Subfamily DSP14 111-163 2.8e-07 24.6 In-house 75-127 (157) alignment
Range on Protein: 111-163
Range on HMM: 75-127/157.0
KVMSFALQEGKTAVHCHAGLGRTGVLICCYFIYSDRLTAEEAIHLMRKNRPKA
|. .   ..||| ||| ||  |   |   | .   .|. .|| .|... ||  
kieevkkkggktlvhCvaGvSRSAslclaylmkyeklsLreayklvksaRpii

subfamily_DSP12_pd Subfamily DSP12 113-179 5e-10 34.0 In-house 75-142 (155) alignment
Range on Protein: 113-179
Range on HMM: 75-142/155.0
MSFAL-QEGKTAVHCHAGLGRTGVLICCYFIYSDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDFYKF
.. || .||.  |||.||. |   ..  |......|  |.|..|... .|..    | .|  | |.| 
ieealeeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkpeiepNegFleQLklfekm

subfamily_DSP1_pd Subfamily DSP1 116-162 1.4e-08 29.0 In-house 92-138 (163) alignment
Range on Protein: 116-162
Range on HMM: 92-138/163.0
ALQEGKTAVHCHAGLGRTGVLICCYFIYSDRLTAEEAIHLMRKNRPK
  ..||  .||.||. |   |.  |.. ..|.. ||| ......|. 
kkknGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRsi

subfamily_DSP19_pd Subfamily DSP19 116-173 5.7e-08 27.2 In-house 85-143 (152) alignment
Range on Protein: 116-173
Range on HMM: 85-143/152.0
ALQE-GKTAVHCHAGLGRTGVLICCYFIYSDRLTAEEAIHLMRKNRPKAVQTRGQIECV
|... |   |||.||  |.  ..  |.. . .|. |||..|.|. || .    | |. .
arskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpcikPneGFikqL

subfamily_DSP15_pd Subfamily DSP15 117-177 8.1e-07 23.2 In-house 76-136 (151) alignment
Range on Protein: 117-177
Range on HMM: 76-136/151.0
LQEGKTAVHCHAGLGRTGVLICCYFIYSDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDFY
|.|..  ||| ||. |   |.  |..    |  ..|.. ....|  |    |  . .|.. 
lkeenvlvhClaGvsRsvtlvvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeye

subfamily_LRR-DSP_pd Subfamily LRR-DSP 118-181 1.9e-08 27.7 In-house 196-259 (263) alignment
Range on Protein: 118-181
Range on HMM: 196-259/263.0
QEGKTAVHCHAGLGRTGVLICCYFIYSDRLTAEEAIHLMRKNRPKAVQTRGQIECVKDFYKFLS
..|   ||| ||. |.  |. .|..  .||. .||. |. |.||.    .| .. .| . | |.
kkGGvlvhcraGvsrsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklf

subfamily_RNGTT_pd Subfamily RNGTT 119-169 1.2e-11 38.6 In-house 113-163 (189) alignment
Range on Protein: 119-169
Range on HMM: 113-163/189.0
EGKTAVHCHAGLGRTGVLICCYFIYSDRLTAEEAIHLMRKNRPKAVQTRGQ
|   .|||. |  ||| ||..| .      .|.|..| .|.||. .     
eevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedy

subfamily_DSP11_pd Subfamily DSP11 120-166 3.1e-09 31.0 In-house 117-163 (178) alignment
Range on Protein: 120-166
Range on HMM: 117-163/178.0
GKTAVHCHAGLGRTGVLICCYFIYSDRLTAEEAIHLMRKNRPKAVQT
   .|||  |. ||| ||| |.|  . . .|.||. . . |  ... 
kligvhCthGvnrtGyliCrylidvegyepedaieafeearGhsler

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 120-176 7.3e-06 20.0 In-house 229-290 (297) alignment
Range on Protein: 120-176
Range on HMM: 229-290/297.0
GKTAVHCHAGLGRTGVLICCYFIYSD----RLT-AEEAIHLMRKNRPKAVQTRGQIECVKDF
  . ||| ||.||.||.. .  | .     |.  .   .. .|..|.. |||  | | . |.
ayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyda

subfamily_DSP10_pd Subfamily DSP10 121-162 6e-06 20.2 In-house 94-135 (159) alignment
Range on Protein: 121-162
Range on HMM: 94-135/159.0
KTAVHCHAGLGRTGVLICCYFIYSDRLTAEEAIHLMRKNRPK
.  |||.||. |   ..  | ..  .|. ..| ......|| 
rvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekrpi

subfamily_PTPN14_pd Subfamily PTPN14 122-173 4.7e-06 20.8 In-house 232-288 (300) alignment
Range on Protein: 122-173
Range on HMM: 232-288/300.0
TAVHCHAGLGRTGVLICCYFI-----YSDRLTAEEAIHLMRKNRPKAVQTRGQIECV
  ||| || |||||||   ..       ...  ..... .|. |   ||| .| . |
vlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfv

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 122-159 7.8e-06 19.8 In-house 265-302 (350) alignment
Range on Protein: 122-159
Range on HMM: 265-302/350.0
TAVHCHAGLGRTGVLICCYFIYSDRLTAEEAIHLMRKN
  ||| || ||||.|.   .. || .  |.  . .|| 
ilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkl