Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
0040695 | (Phosphotyrosine protein) phosphatases II | 1-263 | 1.6e-52 | 172.5 | In-house | 32-385 (388) | alignment | ||
Range on Protein: 1-263
Range on HMM: 32-385/388.0
INLFFQVCASYPTSVIVPLGVSDDELKASAQFRHGARFPVLCYFHKATQSVLMRSGEPLCGSMSNkRCKEDEKLVNSALG---SMKKGMIVDTRSTPAVM
.| ...| ||| ..|| .||..|| .|.||.. |.|||.|.|. ...||.||..||.| . . |..|||||... |. . .|..|||.|.. ..
vNenyelcpsYPallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplvgllls.rsledeklleailkllpnlskllivdlrpklnal
NSRSKGLKIALTTP--------------------------NVLSFKDCHPLLFLWEtphlrlSAPHHASVVQFLIVVVVLFAIVPLEV--YLGHCLGSR-
| .| .. .. ..|...| ..|| |.| . . ..| ..|... .. |. | || .
anralgggvenedaypnaeliflnipnihvvreslqklldaclnvpdslnllslle......esgwldliklilelavlivklldlgnssvlvhcsdgwd
----------------------FQSLVDREWIRGGHPFSNRCTRvGFSSTKYKGQGPVFLLFLDCVWQIYQQFPCSFEFHDSFLICLFEHAYYSQFVAPL
||.|. .||. ||.|..|. . . |... |. ||||||||||||...|||..||| . .|. |..|.|...| |
rtsqlssLaqllldPyYRTleGFqvLiekeWlsfghkfadRlgh.leseidskefsPvFllFLdcvwqLlrqfPtaFeFnerlLlfLadhlyscrfgtFl
TSCA---------------------------------------------SQQVLWPGLYLKW
. .. .|| ..||.|
fnsekerlelsvsertlslwsyllsrkseflnplYdpsslevllpslsvldlllWleyylrw
|
|||||||||
Myotub-related | Myotubularin-like phosphatase domain | 1-106 | 2.3e-30 | 98.5 | Pfam-A | 46-156 (353) | alignment | ||
Range on Protein: 1-106
Range on HMM: 46-156/353.0
INLFFQVCASYPTSVIVPLGVSDDELKASAQFRHGARFPVLCYFHKATQSVLMRSGEPLCGSmSNKRCKEDEKLVNSAL------GSMKKGMIVDTRSTP
.| ...|.|||. .||| .||.||| .|.||.. |.|||.|.||....||.||..|| | .|||.||||||...|. .. || .|||.|..
vNenYelcesYPaklivPksisdeelkkvakfrskkRlPvlsyrhkengavlvRssqplvgl.lnkrskedeklleaaisaekskkekkkllivDarkkl
AVMNSRSKGLKI
... ..|| ..
nalankakgggv
|
|||||||||
Myotub-related | Myotubularin-like phosphatase domain | 1-106 | 2.3e-30 | 98.5 | In-house | 46-156 (353) | alignment | ||
Range on Protein: 1-106
Range on HMM: 46-156/353.0
INLFFQVCASYPTSVIVPLGVSDDELKASAQFRHGARFPVLCYFHKATQSVLMRSGEPLCGSmSNKRCKEDEKLVNSAL------GSMKKGMIVDTRSTP
.| ...|.|||. .||| .||.||| .|.||.. |.|||.|.||....||.||..|| | .|||.||||||...|. .. || .|||.|..
vNenYelcesYPaklivPksisdeelkkvakfrskkRlPvlsyrhkengavlvRssqplvgl.lnkrskedeklleaaisaekskkekkkllivDarkkl
AVMNSRSKGLKI
... ..|| ..
nalankakgggv
|
|||||||||
subfamily_Dicty-MTMR1-like_pd | Subfamily Dicty-MTMR1-like | 1-103 | 1.6e-24 | 78.8 | In-house | 41-145 (404) | alignment | ||
Range on Protein: 1-103
Range on HMM: 41-145/404.0
INLFFQVCASYPTSVIVPLGVSDDELKASAQFRHGARFPVLCYFHKATQSVLMRSGEPLCGsMSNKRCKEDEKLVNSALG---SMKKGMIVDTRSTPAVM
|| ...| .|| ..|| .||.||| .|.||. |.|||.. |. ..|...|| || | ....|..|||||.|| .... .|.|.|.. .
insdyelcetYPkllvvPesisDeelkkvasfRskgRiPvlswrhrsknstitRssqplvG.ltksrseedEklinsirkaktqletlyildarpkanav
NSRSKG
....||
ansakg
|
|||||||||
subfamily_MTMR1_pd | Subfamily MTMR1 | 1-103 | 1.1e-21 | 69.6 | In-house | 32-136 (389) | alignment | ||
Range on Protein: 1-103
Range on HMM: 32-136/389.0
INLFFQVCASYPTSVIVPLGVSDDELKASAQFRHGARFPVLCYFHKATQSVLMRSGEPLCGsMSNKRCKEDEKLVNSALGSMKKG---MIVDTRSTPAVM
.| ...| .||. ..||. |||..|| .|.|| |.|||....| .|.|..|. .|| | .|.||.|||||... .| . .. .|.| ||. . .
lnkkyelcdtYpavlvvpkvvsdedlkkvaafrskgRlPvlswlnkenqavilrasqplvG.lsgkrskedekylqaileanaqsekllildarssvnav
NSRSKG
. . ||
ankakg
|
|||||||||
subfamily_MTMR5_pd | Subfamily MTMR5 | 1-66 | 1.7e-13 | 42.2 | In-house | 36-101 (483) | alignment | ||
Range on Protein: 1-66
Range on HMM: 36-101/483.0
INLFFQVCASYPTSVIVPLGVSDDELKASAQFRHGARFPVLCYFHKATQSVLMRSGEPLCGSMSNK
.| ..|| ||| ..|| ||||... |. . |.|| .. |. ....|.|||.. .. ..
vNkkytvcrsYPalivvPsevsddsiarvakcfrqnRlPvvtWrhernkalLiRsggfeskgvvgl
|
|||||||||
subfamily_Ank-MTMR1_pd | Subfamily Ank-MTMR1 | 1-93 | 1.3e-09 | 29.3 | In-house | 47-140 (405) | alignment | ||
Range on Protein: 1-93
Range on HMM: 47-140/405.0
INLFFQVCASYPTSVIVPLGVSDDELKASAQFRHGARFPVLCYFHKATQSVLMRSGEPLCGsMSNKRCKEDEKLV-NSALGSMKKGM-IVDTRST
|| ...|.||..|..| | .|. || | | | . .... . | .|| | . || ||| . . || . | . ..|.|
inkeykmcssyssslvvlskaldkdlekifsfrskgripslswkdpssnasisrcsqplvg.ierarcpedelycsslalsapsktlylidarpk
|
|||||||||
subfamily_MTMR9_pd | Subfamily MTMR9 | 2-166 | 5.7e-53 | 172.4 | In-house | 40-214 (393) | alignment | ||
Range on Protein: 2-166
Range on HMM: 40-214/393.0
NLFFQVCASYPTSVIVPLGVSDDELKASAQFRHGARFPVLCYFHKATQSVLMRSGEPLCGSmSNKRCKEDEKLVNSALGSMKKGMIVDTRSTPAVMNSRS
| |.||||||.||||| ...|.||||||.||.|.|||||.|.||.|..||.||..||||| |.|||||||||.|..|...|||.||||||..|..|.||
NknfkvcasypesvivPkaiddeelkasaafreggrfPvLsylhketkavllrssqplcgs.sgkrckedekllnlvlkklkkGlivdtrsksaaenars
KGLKIALTTPNVLSFKDCHPL-----------LFLWETPHLRLSAPHHASVVQFLIVVVVLFAIVPLEVYLGHCLG
|| .|. .. .. . |....| .|... ...||. ...| .. . .. . ... ..... .||
kgggietevkysqwkkasrslesvasiqdslaklleacsdaglstdkflsrleksgwlsqvadlleaalvvaqcld
|
|||||||||
subfamily_MTMR3_pd | Subfamily MTMR3 | 2-82 | 2.3e-20 | 65.8 | In-house | 50-129 (442) | alignment | ||
Range on Protein: 2-82
Range on HMM: 50-129/442.0
NLFFQVCASYPTSVIVPLGVSDDELKASAQFRHGARFPVLCYFHKATQSVLMRSGEPLCGSMSnKRCKEDEKLVNSALGSM
| |..|.|||. .||| ..||.|| .|.|| |.|.. . || ...||.|.. | | .. |..|||||.... .
nsdfklCssyPkklivPksitdddlkkvasfrslkrlPavvwrhkkngavlarcsqPevgwlg.Wrnaedekllkaiakac
|
|||||||||
subfamily_MTMR6_pd | Subfamily MTMR6 | 2-102 | 8.8e-19 | 60.0 | In-house | 44-145 (397) | alignment | ||
Range on Protein: 2-102
Range on HMM: 44-145/397.0
NLFFQVCASYPTSVIVPLGVSDDELKASAQFRHGARFPVLCYFHKATQSVLMRSGEPLCGSMSnkRCKEDEKLVNSAL---GSMKKGMIVDTRSTPAVMN
| ...| .||... || .. . | .|..|| |.||| |.||.... . |. .||.| . ||.|||||.. . . ..|||| .
nkdyelcdtyprelyvPksatkevlvgsskfrskgrlPvlsylhkeneaaicrcsqplsgfsa..rcledeklleairkanpnsellyvvdtrpklnala
SRSK
...
nkaa
|
|||||||||
subfamily_MTMR10_pd | Subfamily MTMR10 | 2-75 | 1.6e-07 | 22.4 | In-house | 32-105 (380) | alignment | ||
Range on Protein: 2-75
Range on HMM: 32-105/380.0
NLFFQVCASYPTSVIVPLGVSDDELKASAQFRHGARFPVLCYFHKATQSVLMRSGEPLCGSMSNKRCKEDEKLV
| .|... ..|. ..|| .||.... . . .|||.... | ....|. |.. |. .. . . ||
nelfaaaqtlPqyfvvpnslsdsdverlsrhykesRfplwvwshakgaallrlsalqeaesadkekeekmlelv
|
|||||||||
subfamily_pats1_pd | Subfamily pats1 | 6-55 | 5.2e-06 | 17.1 | In-house | 35-83 (691) | alignment | ||
Range on Protein: 6-55
Range on HMM: 35-83/691.0
QVCASYPTSVIVPLGVSDDELKASAQFRHgARFPVLCYFHKATQSVLMRS
... || ..|| |||. |..... |. ..|||.. ... .|.|.|
dlseiyPkrilvPklvsdellvsyvrkrs.skiPvlswsnqnnksslfri
|
|||||||||
subfamily_MTMR9_pd | Subfamily MTMR9 | 168-253 | 1.3e-44 | 144.8 | In-house | 251-336 (393) | alignment | ||
Range on Protein: 168-253
Range on HMM: 251-336/393.0
RFQSLVDREWIRGGHPFSNRCTRVGFSSTKYKGQGPVFLLFLDCVWQIYQQFPCSFEFHDSFLICLFEHAYYSQFVAPLTSCASQQ
.|..|..||||..||||..|...|....||.| .|||||||||||.||..|||.||||....||.||||.|.|||.. |.......
gfealiereWiqaGHPFasRaskvaaketkkklsgpvfllFLDcvyqilsqfpasFEFneelLillfehsyssqfgtflcdneaer
|
|||||||||
subfamily_MTMR3_pd | Subfamily MTMR3 | 168-250 | 5.5e-23 | 74.4 | In-house | 303-384 (442) | alignment | ||
Range on Protein: 168-250
Range on HMM: 303-384/442.0
RFQSLVDREWIRGGHPFSNRCTRvGFSSTKYKGQGPVFLLFLDCVWQIYQQFPCSFEFHDSFLICLFEHAYYSQFVAPLTSCA
|. ||.|||. || |..||. | . . . . |||| .||.| |. .|||.|||| ..||. | .|.| . | . |. ..
GfkvlvereWldfGhkfadrcgh.genvddanercPvflqwldavhqlqrqfPtsfefneaflvklvqhtysclfGtflanse
|
|||||||||
subfamily_Ank-MTMR1_pd | Subfamily Ank-MTMR1 | 168-253 | 5.6e-13 | 40.4 | In-house | 267-349 (405) | alignment | ||
Range on Protein: 168-253
Range on HMM: 267-349/405.0
RFQSLVDREWIRGGHPFSNRctrVGFSSTKYKGQGPVFLLFLDCVWQIYQQFPCSFEFHDSFLICLFEHAYYSQFVAPLTSCASQQ
|| |...||. || || | .| . . . |.| ||||..|. .||| ||| |.|. . . . .. . | | ..
gfqvliekewlsfghkfslr...lghlpgneeerspifqqfldccfqllsqfpllfeftpslllfisdnihsckygtflnncekdr
|
|||||||||
Myotub-related | Myotubularin-like phosphatase domain | 169-252 | 2e-30 | 98.8 | Pfam-A | 266-349 (353) | alignment | ||
Range on Protein: 169-252
Range on HMM: 266-349/353.0
FQSLVDREWIRGGHPFSNRCTRVGFSSTKYKGQGPVFLLFLDCVWQIYQQFPCSFEFHDSFLICLFEHAYYSQFVAPLTSCASQ
||.||..||. ||.|..|.. .... | ..||||.|||||.|...|||..||| . |||.|.||.| .|| |. . ..
fqvLvekeWlsfGhkFaeRvghlkenkksskesspvFlqFlDcvyqllrqfptaFeFneefLiklvehlyscqfgtFLlnseke
|
|||||||||
Myotub-related | Myotubularin-like phosphatase domain | 169-252 | 2e-30 | 98.8 | In-house | 266-349 (353) | alignment | ||
Range on Protein: 169-252
Range on HMM: 266-349/353.0
FQSLVDREWIRGGHPFSNRCTRVGFSSTKYKGQGPVFLLFLDCVWQIYQQFPCSFEFHDSFLICLFEHAYYSQFVAPLTSCASQ
||.||..||. ||.|..|.. .... | ..||||.|||||.|...|||..||| . |||.|.||.| .|| |. . ..
fqvLvekeWlsfGhkFaeRvghlkenkksskesspvFlqFlDcvyqllrqfptaFeFneefLiklvehlyscqfgtFLlnseke
|
|||||||||
subfamily_MTMR10_pd | Subfamily MTMR10 | 169-292 | 3.1e-26 | 84.0 | In-house | 221-348 (380) | alignment | ||
Range on Protein: 169-292
Range on HMM: 221-348/380.0
FQSLVDREWIRGGHPFSNRCTRVGFSSTKYKgqgPVFLLFLDCVWQIYQQFPCSFEFHDSFLICLFEHAYYSQFVAPLTSCASQQVLW-----PGLYL--
||||...||. .|||| .|. .. |... . ||||||||||.| .||| .||| ..||| |. . . . | | ...|.. | |
fqsliqkewvaaghpfldrlghikpsekses...pvfllFldcvdqlleqfpseFeFtetfLialwdsshsgifltflfnseeqrlkavvsssplliaks
KWQKQQRNGDSFWLEARRVQDLNKDLKLQAA
...... | . .. .. |... .||
elkendllkdeldyrqglyaeiiksirrlaa
|
|||||||||
subfamily_MTMR1_pd | Subfamily MTMR1 | 169-252 | 4.5e-25 | 80.8 | In-house | 247-329 (389) | alignment | ||
Range on Protein: 169-252
Range on HMM: 247-329/389.0
FQSLVDREWIRGGHPFSNRCTRvGFSSTKYKGQGPVFLLFLDCVWQIYQQFPCSFEFHDSFLICLFEHAYYSQFVAPLTSCASQ
|. |...||. ||.|..| .. | .... . ..|||| |.|||||. .|||. ||| ..|||.| .| | . | . | . ..
fevliekeWlsfGHkfkeRlgh.gdknssdaersPvFlqfiDcvwqltrqfptAFefneefLitlldhlysclfGtflfnseke
|
|||||||||
subfamily_MTMR6_pd | Subfamily MTMR6 | 169-251 | 3.4e-22 | 71.3 | In-house | 258-337 (397) | alignment | ||
Range on Protein: 169-251
Range on HMM: 258-337/397.0
FQSLVDREWIRGGHPFSNRCTRVgfsSTKYKGQGPVFLLFLDCVWQIYQQFPCSFEFHDSFLICLFEHAYYSQFVAPLTSCAS
|. |...||. || ||.|| . ... | |.|. ||.||||. .|||..||| ..||. | .| | .|| . |. |
flvliekewlsfGhkfsercGll...dedskevsPiftqflecvwqlleqfpkafefnerfllelhdhvyscqfGtflgncek
|
|||||||||
subfamily_MTMR5_pd | Subfamily MTMR5 | 169-252 | 2.1e-21 | 68.3 | In-house | 332-413 (483) | alignment | ||
Range on Protein: 169-252
Range on HMM: 332-413/483.0
FQSLVDREWIRGGHPFSNRCTRVGFSSTKykGQGPVFLLFLDCVWQIYQQFPCSFEFHDSFLICLFEHAYYSQFVAPLTSCASQ
|. ||..||. || |..|.... ... | |||| |||||.|. .||| .||| | .| | | .| |. . .
FkvLveKEWLafGHrFtkrsnqtlsaqss..gfaPvFlqFLDcvhqvsrqfPlafefndfylkflayhsvsnrfrtfllDseye
|
|||||||||
subfamily_Dicty-MTMR1-like_pd | Subfamily Dicty-MTMR1-like | 169-252 | 5.1e-21 | 67.3 | In-house | 257-338 (404) | alignment | ||
Range on Protein: 169-252
Range on HMM: 257-338/404.0
FQSLVDREWIRGGHPFSNRCTRvgFSSTKYKGQGPVFLLFLDCVWQIYQQFPCSFEFHDSFLICLFEHAYYSQFVAPLTSCASQ
|..|...||. || | .|... .... . . |.|| |.|||.|. .||| |||| ..||| . .. | ..| | . .
FivliekewlsfGhkfaqRigq..ttekssdersPiflqFidcvyqltkqfptsFeFnekflikildalyscrfgtFLydseke
|
|||||||||
subfamily_pats1_pd | Subfamily pats1 | 199-250 | 7.3e-12 | 36.5 | In-house | 550-601 (691) | alignment | ||
Range on Protein: 199-250
Range on HMM: 550-601/691.0
KGQGPVFLLFLDCVWQIYQQFPCSFEFHDSFLICLFEHAYYSQFVAPLTSCA
.. |.|. ||| |||....|| ||| .|.|. | .... |.| . | | |
rsfsPifvqfldlvwqlqkefPfhfefneslllllvkesfssrfGnflysea
|