Gene NvecPTP-sf6-1 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily NvecPTP-sf6
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP065_AA protein Get Run
NvecP065_AA_3-278 phosphatase_domain Get Run
NvecP065_AA_287-571 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1-315 2.2e-164 541.1 In-house 2-318 (318) alignment 
Range on Protein: 1-315
Range on HMM: 2-318/318.0
ISIDDFEQHVARMRRSGDLFFTTEYERI-PVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAET
||..|.|.||.|.|.||.|....||||. ...|.||...||.|||..||||.||.||||.|||||..|.|.||||||||...||||..||||||.||.||
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

CRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGSLSYEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFV
..|||||||||||..|.|||...||...|...||||.|| ||....|.|.. .||. |..|...|.|......|||.|.|.|||||.|||.|...||..|
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlv

RDSTRAD-PPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSASDLRSHIRRLQE
|....|. ..||||.||||||||||||.||..|..|..|..|..||....|..||..||||||||.||.||.|.||.|..||.||..||||||.||.|.|
rqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelre

QDPESGYTPMFTEFQKL
||||||.|.|..|||.|
qdpesgttemdaefqrl
subfamily_PTPRD_pd Subfamily PTPRD 1-318 4.3e-152 502.6 In-house 5-322 (564) alignment 
Range on Protein: 1-318
Range on HMM: 5-322/564.0
ISIDDFEQHVARMRRSGDLFFTTEYERIPVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETC
|.......|||... ..|| |..||..|  ....| ...  |.|..|||| ||||||||||.|. .| ..|||||||.|. |||...||||.|||||||.
ipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaeti

RDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGSLSYEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVR
.|||||||||||.||.|||.|.|. ..||..|||..|. .|...|||| . .||. |..||......  ...|.|.|||||||||||||.| ..||...|
edFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlir

DSTRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSASDLRSHIRRLQEQD
..... .|.|||.||||||||||||||||||.||..|.||||||| ..|..||..|| |||||.||||||.|.|.|. .|.|| ....|..|...|.|..
kvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLaeve

PESGYTPMFTEFQKLSRC
.....| . .|||.|. .
edtemtgleleFqrLata
subfamily_PTPRG_pd Subfamily PTPRG 1-291 1.5e-113 374.9 In-house 1-301 (563) alignment 
Range on Protein: 1-291
Range on HMM: 1-301/563.0
ISIDDFEQHVARMRRSGDLFFTTEYE---RIPVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGS-DYINANFLPGYRRDNAYIAAQGPL
. ...|..||| .  .||  |. |.|   .  ......|.|| .| |..||||.||||||.|||||..  .. .. ||||||.. ||.. .|.||.||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

AETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGSLSYEDITVTLDSVTELTPYIVRTLSVQR------EGCDDVRQVKQFHFTSWPDHGVPT
..|. |||||.||||. .|.|.|||.|| | || .|||. .|. |. ..||| .   |. | ||||...       . ||....|.|.|.|.|||||||.
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe

SVCNLLAFVRDSTRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSASDLR
.    | ||. | .| .  |||.|||||||||||||.||.| .|.||..|..|...||. ..| .|| .|||| ||||.|||||.|| |.||| .|....
hslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqve

S
.
e
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1-313 4.2e-111 366.0 In-house 5-319 (319) alignment 
Range on Protein: 1-313
Range on HMM: 5-319/319.0
ISIDDFEQHVARMRRSGDLFFTTEYERIPVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETC
| ........ ... .|.  .  |.. .  .. .| ...  . |..|||| ||.|||..||.|..... .|||||||.|. ||.. ...||.|.||..| 
ievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlenti

RDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGSLSYEDITVTLDSVTELTPYIVRTLSVqREGCDDV--RQVKQFHFTSWPDHGVPTSVCNLLAF
 ||||||||..| ...|||.|.|. . |. .|||.    .|  ..|||..  ||  ||.| |.. ..  ..|  |.||.|..|.||||.||..   ||..
edfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPekatslldl

VRDSTRADP-PGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSASDLRSHIRRLQ
...  ..   . .||.||||||||||||||||.|.||....|| ..|.  .||.||  ||.|||...||.||..|||.|. .|.||    |||  ...|.
lkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqla

EQDPESGYTPMFTEFQ
|.....| | .  |||
ekvadtgetglerefq
subfamily_PTPRB_pd Subfamily PTPRB 1-282 1e-107 354.6 In-house 7-290 (293) alignment 
Range on Protein: 1-282
Range on HMM: 7-290/293.0
ISIDDFEQHVARMRRSGDLFFTTEYERIPV-PEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAET
|....||.||..|..  || |. |||..    .. . . .  .||. |||| ||..||||||||.. .||.||||||||..|||.  . .||.|||| ||
iklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpet

CRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSR-GSLSYEDITVTLDSVTELTPYIVRTLSVQRegCDDVRQVKQFHFTSWPDHGVPTSVCNLLAF
  ||||||||..|..|.|||.| |. . || .|||.   .  | ||.||| . .||. ...|.|....   .. |.|.|.||||||||||| .  .||.|
vddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldf

VRDSTRAD--PPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGET
||   .|      ..|.||||||||||||||| .| .||.|.|| .|||.|.|. ||..|||.||||.||||||...|| . ..|.
vrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkkee
0051299 (Phosphotyrosine protein) phosphatases II 1-277 7.1e-106 349.1 In-house 5-286 (288) alignment 
Range on Protein: 1-277
Range on HMM: 5-286/288.0
ISIDDFEQHVARMRRSGDLFFTTEYERIPVPE-HVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAET
||.......| .....|  ..  |.|...    ..| ...| | |..|||| .|..||||||||.......|||||||....||......||.|||| .|
isveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpnt

CRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGSLSYEDITVTLDSVTELTPYIVRTLSVQRE----GCDDVRQVKQFHFTSWPDHGVPTSVCNL
. ||||||||||.|.|.|||.| |. | |||||||..||| |.|||||| |...|  |.|||| |..     |.. .|.|..||.|.|||||||.|.  |
vedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspell

LAFVRDSTRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAI
|.|.|.  .| ..| ||.|||||||||||||||..|..|.|...|..||.|..| .||..|. ||||..||.|...|||...
ldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0043336 (Phosphotyrosine protein) phosphatases II 1-275 2.4e-97 321.0 In-house 2-275 (278) alignment 
Range on Protein: 1-275
Range on HMM: 2-275/278.0
ISIDDFEQHVARMRRSGDLFFTTEYERIPVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETC
||. |........ ...   .  |.|...   . | ...| | |..|||| .|..||||||||.... ...||||||....||.. ...||.|||| ||.
isvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetv

RDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPsRGSLSYEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVR
 ||||||||....||.|||.|.|. | ||||||| .||| |.|.|||| ....|  |.|||| | . |.. .|.| ..|...|||||||.|.  || |..
edFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflk

DSTRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLD
.  .| ..  ||..||||||||||||||.....|.|.. |..||..  |..||..|  .|||..||.|...|||.
avrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1-297 6.1e-92 303.0 In-house 4-303 (305) alignment 
Range on Protein: 1-297
Range on HMM: 4-303/305.0
ISIDDFEQHVARMRRSGDLFFTTEYERIPVPEHVTAThSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETC
|..||.....  .|   |  . ..|. ..  |. .     . .|..|||. .|. .|..|..|.  |... ||||||... ||.| ..||.||||| .| 
ialddlaayikearvysdkgleaqykslyeeeesidv.gkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntv

RDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGSL--SYEDITVTLDSVTELTPYIVRTLSVQR-EGCDDVRQVKQFHFTSWPDHGVPTSVCNLLA
.||||...|   .||.|||.|.|  .||| |||| . .    .....|.| | .. . || | |..   .. .. |.| |...|.|||||||..   || 
adfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatslls

FVRDSTRADPPGAG-PMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSASDLRSHIRRL
.... ...   . | |..|||||||||||.||..|..|.....|..||. . . .||..|  |||| .|| |.|||| . |..|.|.   |.|| .. .|
likrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnkl

Q
.
k
subfamily_Ptp69D_pd Subfamily Ptp69D 1-296 2.9e-90 297.5 In-house 4-305 (307) alignment 
Range on Protein: 1-296
Range on HMM: 4-305/307.0
ISIDDFEQHVARMRRSGDLFFTTEYERIPVP-EHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAET
|.||| |. .   .|  |  .. |||...    . ... |    |. |||| .|.|.|. ||||.  . .  ||||||.|. ||.  . .||||.|. .|
iaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveat

CRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGSLSYEDITVTLDSVTELTPYIVRTLSVQREG-----CDDVRQVKQFHFTSWPDHGVPTSVCN
  |||||..||.. .|.||.||.|  |.|||.|||      |.|| |.| |  . . || |.|.| . .      .| |.| |.|.|.|.|  || .   
igDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevarg

LLAFVRDSTRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSASDLRSHIR
|| ...          .|.||||||||||.|.|. .|..|||...|..|||  .|  ||..|||.||  .||.|.. |||| .  |.|. .  || ..|.
llklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaie

RL
||
rl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1-289 2.4e-89 294.4 In-house 6-290 (315) alignment 
Range on Protein: 1-289
Range on HMM: 6-290/315.0
ISIDDFEQHVARMRRSGDLFFTTEYERIPVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETC
| .|..  .||. . |    |  .|| ||  .      . .  |..|||||||.|||.|||.|   | .|.|||.||||..|| . . |||||||.... 
ipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasv

RDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRgSLSYEDITVTLDSVTELTPYIVRTLSVQREgcDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVR
.||||.|.|..  .|.||||| |. . |. .||| .  . |  ||||. |    | | ||||||  .  |..|.| |.|.||||| ||| .  .|. ..|
kdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtlsvvfg..dnirevvqlhytswpdmgvpkytiplmnlir

DSTRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETsASDL
   . .   .|..||||||||||||||| .| .|.|.. |. .|.  |.  .|. |  |||. .|| ||.||||.... |.|   | ||
tvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsi.aqdl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1-284 9.3e-74 243.0 In-house 2-285 (287) alignment 
Range on Protein: 1-284
Range on HMM: 2-285/287.0
ISIDDFEQHVARMRRSGDLFFTTEYERIPV--PEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQdfedEPGSDYINANFLPGYRRDNAYIAAQGPLAE
|... | . ||. .. |.  |.. .  .     ..   ||.. . |..|||. .|. .|  || |.    .   ||||| |. ||. ..|.|.|..|...
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfn

TCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGSLSYEDITVTLDSVTELTPYIVRTLSVQREG-CDDVRQVKQFHFTSWPDHG-VPTSVCNLL
| |.||......|  .|.||...||  ...| ||||.  |... . ...| . .  . ||.|.| |....  .| .||||...|.|...| |..    ||
tarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtill

AFVRDSTRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETET
 . .       .| ...|||||..|||...|. ... ... ..| ..|..  .   |  .  .||| .||.|| |..|  . |.|| .
vieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1-282 8.4e-72 236.5 In-house 2-288 (290) alignment 
Range on Protein: 1-282
Range on HMM: 2-288/290.0
ISIDDFEQHVARMRRSGDLFFTTEYERIPVPE-HVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPG--SDYINANFLPGYRRDNAYIAAQGPLA
| .|.| ..||  .  |.  | ...... . | . |.|. | . |...||. ||| ||  |. |..  ...    .|||| .. ||. ...|||.|||. 
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

ETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGSLSYEDITVTLDSVTELTPYIVRTLSVQREGC-DDVRQVKQFHFTSWPDHG-VPTSVCNL
.| .|||...|....  |.|||| .|  ..|| ||||.... .|. ....| . ..|. || |.|.|. .   .. ..|.|...|.|...| |.     |
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtil

LAFVRDSTRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGET
|.. .       .| ...|||||..|||...|..... ... . |  .|..  . ..|  .  .|||.||| .|.. .| .. | ||
lvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfet
subfamily_PTPRA_pd Subfamily PTPRA 2-302 1.2e-103 341.5 In-house 15-320 (330) alignment 
Range on Protein: 2-302
Range on HMM: 15-320/330.0
SIDDFEQHVARMRRSGDLFFTTEYERIPV-PEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETC
 ....|. . .        |  |.. .|  | . |   .    |..|||..||. ||.||| |.  | .. |||||| |. ||.. . .||||||..|| 
pvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetv

RDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGSLSYEDITVTLDSVTELTPYIVRTLSVQ--REGC--DDVRQVKQFHFTSWPDHGVPTSVCNLL
 |||||.|||.| ||.|||.|||| ..|||||||. |...| .|.|... .|.|  | || . ||   ...  ...|.|.||||||||| |||.    .|
edfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGml

AFVRDSTRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSASDLRSHIRRL
 ...   . ..  |||.||||||||||||||||.| .|.... |. ||. .||. ||  |  ||||..|| ||. .||.  . |.||  .| | .|...|
kllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlqkl

QEQDPE
... ..
ynkitg
0050432 (Phosphotyrosine protein) phosphatases II 2-280 5.6e-102 336.4 In-house 27-302 (308) alignment 
Range on Protein: 2-280
Range on HMM: 27-302/308.0
SIDDFEQHVARmrRSGDLFFTTEYER-IPVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLqdfedEPGSDYINANFLPGY--RRDNAYIAAQGPLAE
|..|. ... .    .  .. .|.|.   |... . ...| | |..|||| .|..||||||||     ..|||||||.. .||  ......||.|||| .
svldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpn

TCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSR---GSLSYEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNL
|. ||||||||||.|.|.|||.| |. | |||||||.    ||| |...|||| |...|  |.|||| ..  |....|.|..||.|.|||||||.|.  |
tvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeil

LAFVRDSTRADPPgaGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISG
|.|..   .  |.  ||.|||||||||||||||..|..|.|...|..||... | .||..|. ||||..||.|...|||. . . 
ldflelvrkslpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklk
subfamily_PTPRK_pd Subfamily PTPRK 2-313 6.7e-100 329.0 In-house 5-313 (314) alignment 
Range on Protein: 2-313
Range on HMM: 5-313/314.0
SIDDFEQHVARMRRSGDLFFTTEYERIPVPehVTATHslDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCR
 ..|  |..| ..|.    |  ||| ..      |..  .  |..|||. .|.|||.|||.|.  ...| ||||||... .|.| .|.|..|||| || .
rvadllqsiallkraegygfkeeyeslfeg..wdaak..kdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvk

DFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGSLsYEDITVTLDSVTELTPYIVRTLSVQR--EGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFV
||||.|...|. .|.|||.|.|  | || .|||  ..  |.|| |.| ... |. ..||...|..   | ...|.|.||.|..||||.||.|   ||..|
dfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklv

RDSTRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSASDLRSHIRRLQEQ
|     ....||..||||||| |||||||.||..|. |..|..||.   | ||| ..  ||.||.||.||.|..|.| . |||   .|....     .. 
rrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesirl

DPESGYTPMFTEFQ
||..  . .  |||
dpqtnssqlkeefq
subfamily_PTPN9_pd Subfamily PTPN9 2-275 7e-82 269.8 In-house 2-288 (297) alignment 
Range on Protein: 2-275
Range on HMM: 2-288/297.0
SIDDFEQHVARMRRSGdlfFTTEYERIP-VPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETC
.|......|  ....|    . ||. |   | . |...|  ..| .|||| ... ||..||.|.  .... ||||||||. ||.. .|.||.|||| .|.
eieelvayvkekgkrG...lskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktv

RDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWP--SRGSLSYEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAF
.|||||||||. ..|.| | . || | ||.||||  .  | .. |..|.  .| |   | ||.| ...   .. |.|  | |.||||.||| |  .|| .
sdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldv

---VRDS----------TRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLD
   ||.           . . .|   |.|||||||.||||||| .|. |....|. |||.   |..||  |  ..||..|| | . |.|.
lekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
0039614 (Phosphotyrosine protein) phosphatases II 3-277 8.8e-95 312.8 In-house 16-289 (297) alignment 
Range on Protein: 3-277
Range on HMM: 16-289/297.0
IDDFEQHVARMRRSGDLFFTTEYERIPVPEHvTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDE-PGSDYINANFLPGYRR-DNAYIAAQGPLAETC
.. ..... ......  .. .|.|...   .   ...| |.|..||||..|..||||||||.....  ..||||||....||.. ....||.|||| ||.
lsvldlllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetv

RDFWRMVWEQNSRTIIMLTNLKERCRdKCAQYWPSRGSlSYEDITVTLDSVTELTPYIVRTLSVQRegCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVR
 |||||||||....|.|||.|.|. | |||||||..|.  |.|.|||| .|..|  |.||||.|..   . .|.|..|..|.||||||| |.  || |..
edFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslelllefle

DSTRADP--PGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAI
   .|    |. ||..||||||||||||||... ||.|...|..||.|  |..||..|. .|||..||.|..||||. .
lvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 3-287 3.1e-79 261.2 In-house 12-294 (297) alignment 
Range on Protein: 3-287
Range on HMM: 12-294/297.0
IDDFEQHVARMRRSgDlFFTTEYERIPVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRdnAYIAAQGPLAETCRD
. ||   | . |.. | .|. |.  .|  .  ..| . . || .|.|| ||. || |||||.  .|.| |||.|| |..|..    .|. | |  .|  |
lsdfatlvqknrht.d.vfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvad

FWRMVWEQNSRTIIMLTNLKERCRdKCAQYWPSRGSLSYEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPT--SVCNLLAFVR
||.||....  ||.||....|| . |||.||. .|. .. |..|.| ||.| . .| |.|.|...     | |||..|..|||. |.   |.  || .. 
fWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklis

DSTRADP-PGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSAS
.          ||..|||.||||||| .. || .. ....||.|||.|.|. ||..|  .|||..|| |.. |.|.|..| .|.  ||
evrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqas
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 3-290 1.3e-77 256.1 In-house 4-292 (439) alignment 
Range on Protein: 3-290
Range on HMM: 4-292/439.0
IDDFEQHVARMRRSGDLFFTTEYERIPV--PE-HVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAET
 |.|..|| .. .  . .|. ..| |    |. .. |.   .  .| |||| ...|.||.|| ||.    | | |||||.. ||  |. |||.|||  ||
rdefqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkket

CRDFWRMVWEQNSRTIIMLTNLKERCRdkcaqYWPSRGSLSYEDITVTLDSVTELTPYIVRTLSV--QREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLA
. ||||.|.|... ||.||||| |  .     |||| .   | ||.|  |   ||  |..| . |  .|. ..  | | |||...|||. ||.    .| 
tddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvld

FVRDSTRA-DPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSASDLR
|.|    | |    ||.||||||||||||| | .|. |.|.. |. ||| | |. ||..|. |||.  ||.||..|.|. |. |.. ..  ...
flrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefk
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 3-94 1.2e-16 54.6 In-house 7-95 (95) alignment 
Range on Protein: 3-94
Range on HMM: 7-95/95.0
IDDFEQHVARMRRSGDLFFTTEYERIPVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDepgSDYINANFLPGYRRDNAYIAAQG
.  |  ||  |    |  |  |.  |..    . |      |  |||..||. || .|| |    |   |||||| |. || | |.||||||
vsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkrd...sdyinacfvdgyarkncyiaaqg
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 3-81 2.8e-11 37.4 In-house 8-84 (440) alignment 
Range on Protein: 3-81
Range on HMM: 8-84/440.0
IDDFEQHVARMRRSGDlfFTTEYERIPVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLP
. || ..|   |||    |  |.  .|      .  .  | |. |||| ||.||||||| |.. .  | |||||| .. 
vadfadyvqnnrrsra..fedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyin
0040438 (Phosphotyrosine protein) phosphatases II 4-315 4.2e-104 343.5 In-house 3-314 (317) alignment 
Range on Protein: 4-315
Range on HMM: 3-314/317.0
DDFEQHVARMRRSGDLFFTTEYERIPVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDF
 |..... .. .|.   .  |.|...   . | .... |.|..|||| .|. ||||||||....  ..||||||.. .|... ...||.|||| .|. ||
ldlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedF

WRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGSLSYEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDST
|||||||....|.|||.|.|. | |||||||....| |.|.|||| |..||  ...||| |.  |....|.|..||.|.||||||| |   ||.|..   
wrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavr

RADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSASDLRSHIRRLQEQDPES
.| ... ||..||||||||||||||....||.|...|..||.   | .||..|. .|||..||.|..||||. .  ..| ..||.| ... .|.. .. .
ealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplald

GYTPMFTEFQKL
..... .|.. |
dvklkekelkll
0045450 (Phosphotyrosine protein) phosphatases II 4-277 4.7e-93 307.5 In-house 12-304 (307) alignment 
Range on Protein: 4-277
Range on HMM: 12-304/307.0
DDFEQHVARMRRSGDLFFTTEYERIPVPEH---VTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDE-PGSDYINANFL--------PGYRRDNAYIA
 .....|... ...   .  |.|...  ..    . ...| |.|..|||| .|..|||.||||.. ... ..||||||..         .||......||
lkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIa

AQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRG-SLSYEDITVTLDSVTELTPYIVRTLSVQRE-GCDDVRQVKQFHFTSWPDHGVP
.|||| ||. |||||.|||....|.|||.|.|. | |||||||. | .| |...|||| |...|  |.|||| |..  |.. .|.|..||.|.|||||||
tqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvp

TSVCNLLAFVRDSTR--ADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKT---VDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAI
.|.  ||.|..   .  .. |. ||..||||||||||||||....||.|...|.|   ||.|  |..||..|  .||...||.|...|||. .
psfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 4-315 1.8e-81 268.4 In-house 6-315 (315) alignment 
Range on Protein: 4-315
Range on HMM: 6-315/315.0
DDFEQHVARMRRSGdlFFTTEYERIPVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDF
 .|   | . |..   .|. |.  .| |.    . . ...|..|||| ||. .|..||||.  .|.| |||||| .....  |.||||.||||  .  ||
aqfpafvnknrhta..lfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddf

WRMVWEQNSRTIIMLTNLKERCRDKCAQYWPS--RGSLSYEDITVTLDSVTELTPYIVRTLsVQREGcDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRD
||||....  ||.|.|...|  . ||.||||     |  .  | |.| |.   |  ..| | | |.. .. |.| ||.|| |||.||.  .  || ....
wrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrks.eesrtvtqfqftewPdkGvdkqtssllklike

STRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSASDLRSHIRRLQEQDP
    . .   ...||||||||||| .| || ...||.....||.. || .||..|  .||||..| ||.||.|. .   .|      .  |.. |.    
vkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhtsvd

ESGYTPMFTEFQKL
 || . |  ||..|
gsgrskmtkefetl
subfamily_PTPN14_pd Subfamily PTPN14 4-276 6.7e-62 204.2 In-house 10-295 (300) alignment 
Range on Protein: 4-276
Range on HMM: 10-295/300.0
DDFEQHVARMRRSGDLFftTEYERIPVP-EHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEpGSDYINANFLP--GYRRDNAYIAAQGPLAETC
|.  ... .  ..| .|  |||||||   |. . . .  |.|..|||. ... |...||.|.  ...  ..||||  .      ..  ||.|||||  |.
dkrakilekkleegkvf..teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltv

RDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSR----GSLSYEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLL
.|||.|||||. . |.|||. .|  ..|. .|.|.      .. ..   ||   ... . .| ..| ..     . |.|  . .| |||||||  | . |
qdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgfl

AFVRD--STRAD----P---PGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDA
 ....  | |              |..|||||||||||  |. |.... .. ....||   ...||. | |.|||  || |....|.  
syLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 5-315 3.9e-66 218.1 In-house 8-274 (392) alignment 
Range on Protein: 5-315
Range on HMM: 8-274/392.0
DFEQHVARMRRSgDLfFTTEYERIPVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFW
.|   | . |.|  | |. |.  .| |.    | .  ..|..|||| ||. || .||||.  .| | |||.|| ..|..  ..||||.||| | .  |||
qfpafveknrhs.al.ffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfw

RMVWEQNSRTIIMLTNLKERCrdkcaqywpsrgslsyeditvtldsvteltpyivrtlsvqreGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTR
|||...|  ||.|.|.|||                                              ||.| | ||||| |||..||  ...|| |...   
rmvfqenvttiamvtklkegd..........................................kgddartvaqfhftewPdkdvpkhtssllkfikevka

ADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSASDLRSHIRRLQEQDPESG
     . |...||||||||||  | || .. . .. . ||.. ||. .||.|  ||||..|| ||. |.|. ..  .|      .  |.. |.      .
dfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlstssdGdv

YTPMFTEFQKL
 . .  ||..|
rskqlkefrsl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 5-275 6.3e-58 190.8 In-house 4-291 (301) alignment 
Range on Protein: 5-275
Range on HMM: 4-291/301.0
DFEQHVARMRRSGdlfFTTEYERIPVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFE--DEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRD
| ..||| ..  .   |  .|...   |. ..| .|.  |.. ||. ||. ||. |. |.  .  |    .||||... ||.. ...||||||. .| .|
dlgthvaakhsnk...feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvd

FWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRG--SLSYEDITVTLDSVTELTPYIVRTLSVQR-EGCD--------------DVRQVKQFHFTSWPD
|||..|..   .|.|.|||||. ..|| ||||.    | ..  .|||| . . .  ...| |.|.  .| .              . ..| |.. |.||.
fWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpq

HGVPTSVCNLLAFVRDS-TRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLD
.||       |  . |   |   .| ||.|||||..|.|.|... ... | |   |  ||. . . ..|| .  .|.| .||..|.|..  
dGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidm
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 6-322 5.9e-83 273.7 In-house 7-322 (515) alignment 
Range on Protein: 6-322
Range on HMM: 7-322/515.0
FEQHVARMRRSGdlFFTTEYERIPVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWR
|   |.. |.    .|. |.  .| |.    | . . .| .|||| ||. || .||||.  .|.| |||.|| ..|..  |.||||.|||.  .  ||||
fPafvnknrhtt..lfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWr

MVWEQNSRTIIMLTNLKERCRDKCAQYWPS--RGSLSYEDITVTLDSVTELTPYIVRTLSVQREgcDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDST
.|...|  ||.|.|.|||  . ||..|||     |. .  | | | |.   |  | |.| | ..  ||.| | ||||| |||.|||     || ....  
lvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkg..ddsrtvtqfhfteWPdkGvpkhtssllklikevk

RADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSASDLRSHIRRLQEQDPES
      . |...|||||||||| .| || .. .... ..||.. ||  .|..|  .|||..|| ||..|.|. .   .|      .  |.. |.      
adhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgr

GYTPMFTEFQKL-SRCINSS
| . |  ||| | | | .  
grskmtkefqtlkslcpdpp
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 6-304 1.1e-78 259.6 In-house 10-315 (325) alignment 
Range on Protein: 6-304
Range on HMM: 10-315/325.0
FEQHVARMRRSGDLFFTTEYERIPVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWR
. .|| . .   .  |. |.. .|  . .. . .  | |. |||. |.||.|.||| |.  .|.| ||||||..|  ... . ..||| ||..|  |.||
lvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWr

MV--WEqnsRTIIMLTNLKERCRDKCAQYWPSR--GSLSYEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVP---TSVC---NL
.|  |.    ......|  .   |.||.||| .   |  .  . | | .. |.. |. | | |..    . | ||||.. ||.| ||.   ...    .|
lvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilql

LAFVRDSTRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSASDLRSHIRR
.  | .  .|.  ...|..|||||||||||.|| .  .|... ||  |||.|||  ||..|  ||.|  |||.|..|| .|..||.|.   | . ...  
vkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklss

LQEQDPESG
|||..| . 
lqernpltq
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 7-283 2.2e-95 314.4 In-house 15-296 (298) alignment 
Range on Protein: 7-283
Range on HMM: 15-296/298.0
EQHVARMRRSGDLFFTTEYERIPVPEH----VTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRD
.. .| ... .   ...|..|.   ..     . . .  | |..|||| .|.|.|.||| |.. ...  |||||| || .|.. ||.||.|.|| ||  |
qklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetved

FWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGSLSYEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDS
|||||.|... ||.|||||.|  . |. .|||..|.  |..|||.| |  | . .|||.| |...  .. |.|.|.|||||||.|||.  . .|...|. 
FWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkv

TRaDPPGAG--PMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETE
 .  .  ||  |..|.|||||||.||||.|| .|.....|..||..  | .||..|  .||||.||.||..| |.|. |...|
ra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnde
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 7-278 4.5e-90 296.6 In-house 3-277 (281) alignment 
Range on Protein: 7-278
Range on HMM: 3-277/281.0
EQHVARMRRSGDLFFTTEYERIPV-PEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWR
..|....... .  |..||| .     . ||| |  . |..||||.||||||..|||... |..  .|||||||.|||. ...|||.|||. ... .||.
rkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWq

MVWEQNSRTIIMLTNLKERCRDKCAQYWPSRG-SLSYEDITVTLDSVTELTPYIVRTLSVQREGCDDvRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTR
|||||. ..|.|.|.  |  . || .|||    .|.| |.||.  . .| . || |.....||...  |.|.|...|.|||||||..  .|| | .. ..
mvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresget.reveqlaytaWPdhGvPattkellefrkevlk

ADPPG-AGPMVVHCSAGVGRTGTFIVIDVMLQQIHEE-KTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAII
.. .    |.|.|||||||||||.| .| .......| ...|.   |  ||..|||||||  || |.. |.|||. 
ltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 8-277 7.2e-96 315.6 In-house 10-279 (288) alignment 
Range on Protein: 8-277
Range on HMM: 10-279/288.0
QHVARMRRSGDLFFTTEYERI-PVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRM
..||.. ...   |. ||. . .. .. . | .  .||..|||| ||..||. ||||.. |.|.|.|||||... |......|||.|||||.|  |||..
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

VWEQNSRTIIMLTNLKERCRDKCAQYWPSRGS-LSYEDITVTLDSVTELTPYIVRTLSVQREGcdDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRA
|.|... ||.|||.| |. . || .|||. .    | ..|||| .. ||. ...|.| .....  . ....|.....||||||| |  .||...|    |
vyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkk..teleitqyqylaWpdhgvPeskapllellrqvkva

DPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAI
..  .||..||||||||||||||..| ......||...|..|.|. ||..|.|.|||..||.||...||. |
nqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_CG7180_pd Subfamily CG7180 9-281 2.7e-61 201.8 In-house 8-294 (296) alignment 
Range on Protein: 9-281
Range on HMM: 8-294/296.0
HVARmRRSGDLFFTTEYERIPVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVW
 | . ||   . .  |.. .|  |  .  . |   |. |||....| ||. || |. .. |  |||||| .  .. ....||  ..|  ||  .|||.|.
lvdk.rrkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvy

EQNSRTIIMLTNLKERCRdKCAQYWPSRGSLSYEDITVTLDSVTELTPYIVRTLSVQRE----------GCDDVRQVKQFHFTSWPD-HGVPTSVCNLLA
.... ....||.  .  . .. .||| ..   | .| | . .. ...    ||. ....             ..| ||.|..| |.  . || |   |. 
deeisavvvLtktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalie

FVRDS----TRA-DPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGE
..|       .. . |  ||.||..| |..|.| .. ||. |.....|. ||. ..| ||||.|. .|.. ..| .| | ||.|.. . 
lrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 19-293 2e-66 218.8 In-house 9-282 (283) alignment 
Range on Protein: 19-293
Range on HMM: 9-282/283.0
LFFTTEYERIPVPEHVTATHSLDpVNQHKNRYINIVAYDHSRVKLQDFEDepgsDYINANFLP---GYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTI
  |   ..|. ||.  .  .| |  |..|||. .||..|  ||.|.        ||||| |.|    |..|. ||.||.|| .| .|||.||....  .|
klfrevlkrlsvpdldadiasad.enkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitai

IMLTNLKERCRDKCAQYWPSRGSLSYEDITVTLDSVTELTPYIVRTLSVQRE-GCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADPPGAGPMV
.|||.|.|  | ||.||||.|||  | . ||||   |    .|.. | .. .  . .   .  . .  | . |  . .  |. | .  .       ||.|
vmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPiv

VHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSASDLRSHI
||||.|.|||..|| . . ....  |  ||.   |  .| .|  .||| .|| ..|.. |.  . |.|.  | || | |
vhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdlqsti
0049772 (Phosphotyrosine protein) phosphatases II 19-276 2.3e-47 157.6 In-house 21-279 (314) alignment 
Range on Protein: 19-276
Range on HMM: 21-279/314.0
LFFTTEYERIPVPEHVTATHSLDPVNQHKNRYINIVAYDhSRVKLqDFEDEPGSDYINANFLPGYrrdNAYIAAQGPLAETCRDF----------WRMV-
|...  .  . |.   | . . ...|..||||..|. .| .||.| ....  |||||||... |.   ...||.|||| .|. ||          |||| 
lllvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvl

-WEQNSRTIIM---------------------LTNLKERCrdkcaqywpsrG------SLSYEditvtldsvteltpyivrtlSVQREGCDDVRQVKQFH
 ...|.|.| |                     |..| ..            .         ..                    ... .. .  |.. ...
rgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng...........neptaadlellk....................eelydpelferlgikyl

FTSWPDHGVPtSVCNLLAFVRDSTRAdpPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHeektVDILGFVSTLRRHRN-----LMVQTEQQYIFIHDALL
 . .||...| .   ...|..   .|  .  || .|||.||.||||||.|.. .. . .    |..   .. .|. |       .... .||.||..|||
ripvpDgsap.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefileall

DA
..
ey
subfamily_PTPN6_pd Subfamily PTPN6 21-275 1.6e-81 268.7 In-house 28-295 (306) alignment 
Range on Protein: 21-275
Range on HMM: 28-295/306.0
FTTEYERIPVP---EHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQdFEDEPGSDYINANFLPGY--RRDNAYIAAQGPLAETCRDFWRMVWEQNSRTI
|. |.|..      . .. ...  | |..|||| ||. .||.||.|.  .. |||||||||.. .     |..|||.|| | .|  |||||||..||| |
feeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvi

IMLTNLKERCRDKCAQYWPSRGSL-SYEDITVTLDSVTELTPYIVRTLSVQ-REGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADPP----G
.|.|.  || ..|||.|||.  .  .| .|.||  | ..|. ||.|.|||. ..  .. |.| |.||.||||||||..   .|.|..| .|         
vmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeae

AGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEK---TVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLD
|||.|||||||.||||||||||..|..|....    .||  .| ..|..|. .||||||| |.. |.  
agpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 22-297 2.4e-89 294.8 In-house 37-311 (319) alignment 
Range on Protein: 22-297
Range on HMM: 37-311/319.0
TTEYERIPV--PEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLT
  |. |..   ..  . |..  . |. |||.|||.|.|...|||.  . | .|||||| |. ||.| . |||||||| .|  |||||.||.|. ||..||
evefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt

nlkercRDKCAQYWPSRGSLSYEDITVTLDSVTELTPYIVRTLSVQREG-CDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRD--STRADPPGAGPMVVH
      .|||.|||| ..   .|   | .|||.|   |.|| . . ..|   |.|...||||  |||.||| .  .|. .|.     .    .  ..|||
......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvh

CSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSASDLRSHIRRLQ
|||||||||..||.||.|....||| ||.  ||  ||. || .||   || ||. |||.  . | .. .  |. .....| 
csaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleels
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 23-275 4.6e-45 148.7 In-house 10-257 (267) alignment 
Range on Protein: 23-275
Range on HMM: 10-257/267.0
TEYERIPVPEHVTAT--HSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEpgsdYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTN
 |.| |    . ..|   |.   || .||. . . ||..|| |.. |.|    |||| .. ||.. ||.|. |.||  |  ||. .. .|.  .|..||.
kefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltk

LkerCRDKCAQYWPSR--GSLSYEDITVTLDSVTELTPYIVRTLSVQREgCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADpPGAGPMVVHCS
      |.  ..|| .   .  |.|.||      |   | . || .. .  .  ..|  ...  |          . |  .    . .  |  |.||.||
v...ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfk.nesahnvtlyyykkwnintnnkpylkplfgilaknqle.ngnrPlvvacs

AGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLD
.||||.|||.||| .|... .| ..||  |.  .|  |  .|.| ..||.||. | .
dGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
0046845 (Phosphotyrosine protein) phosphatases II 24-281 5.7e-99 326.3 In-house 5-278 (284) alignment 
Range on Protein: 24-281
Range on HMM: 5-278/284.0
EYERIPVPEHV---TATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDE-PGSDYINANFLPGY-----RRDNAYIAAQGPLAETCRDFWRMVWEQNSRT
|.|...   .    . ...| | |..|||| .|..||||||||. .... ..||||||....||     .. ...||.|||| .|. ||||||||||.|.
efeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrv

IIMLTNLKERCRDKCAQYWPSRG-SLSYEDITVTLDSVTELTPYIVRTLSVQREG-CDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADP--PGA
|.|||.| |. | |||||||. | .| |.|.|||| |...   |.||||.....| .. .|.|..||.|||||||||.|. .||.|.|.  .. .  || 
IVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgg

GPMVVHCSAGVGRTGTFIVIDVMLQQIHEEK---TVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGE
||.|||||||||||||||..|..|.|...|.   .||.|. |. ||..|. ||||..||.|...|||... .. 
gpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 24-274 1.6e-76 252.1 In-house 10-265 (274) alignment 
Range on Protein: 24-274
Range on HMM: 10-265/274.0
EYERIPVPEhvTATHSLDPVNQHKNRYINIVAYDHSRVKL-QDFEDEPGSDYINANFLPGYRR-DNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNL
|.  .|.    .  .   . .|.|||| .|.  ..||| | ..  ... |.|||||.. ||.. ..||.|.||||..|  |||||....... |.|||.|
eflelPlnf..dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltkl

KERCRDKCAQYWPSRGSL----SYEDITVTLDSVTELTPYIVRTLSVQRegCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDS--TRADPPG-AGPMV
||. ..|||.|.| . ..     |.|. .. ....|   | ||.|...   . . |.|| . .|.|||| .| .. .|| .|..   .| .    ..|.|
keaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlky..lerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvv

VHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALL
||||||.|||| || |.. ..|..||..||.|. |. || .|  ||||..|| .|| || 
vhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc
subfamily_CG42327_pd Subfamily CG42327 24-199 3.1e-38 126.2 In-house 10-187 (319) alignment 
Range on Protein: 24-199
Range on HMM: 10-187/319.0
EYERIPvpEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRR-DNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLK
|.. .|    .. .  . .  . |.|.||.|   ..|| ||   |.. . |..|... ||.  .| ||||| .| ..  ||||.||||.||.|. ||.| 
efrdlP..qliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdls

ERCRDKCAQYWPSRGS----LSYEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFtSWPDHGVPTSVCNLLAFV
|   ..||.|.|.. .     .| || |||        |.. || ..|   .  |..  . .  |.. .||..   |.| .
elGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliaml
0036941 (Phosphotyrosine protein) phosphatases II 27-289 9.9e-98 322.4 In-house 22-289 (297) alignment 
Range on Protein: 27-289
Range on HMM: 22-289/297.0
RIPVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLqdfeDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCR
  |.    . ...| | |..|||| .|..|||.||||    |..|||||||....||......||.|||| .|. ||||||||||...|.|||.| |. |
llpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgr

DKCAQYWPSR--GSLSYEDITVTLDSVTE--LTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTR--ADPPGAGPMVVHCSAG
 |||||||.   .|| |.|.|||| ||..  |. |..||| |.  |....|.|..||.|.|||||||.|.  ||.|..   .  .  |. ||..||||||
ekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaG

VGRTGTFIVIDVMLQQIH---EEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSASDL
|||.||||..|.||||..   .|..|||| .| .||..|. .|||..||.|...|||. . ...|  ....|
vgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllkl
0045098 (Phosphotyrosine protein) phosphatases II 27-276 3.1e-84 277.9 In-house 16-271 (278) alignment 
Range on Protein: 27-276
Range on HMM: 16-271/278.0
RIPVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKlqdfedepgsDYINANFLPGYrrDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCR
 .. .   . |..| . |..|||| .|..|||||||          |||||....||  ....||.|||| .|. |||||.||.....|.|||.|.|. |
llllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgr

DKCAQYWPSRGSLSYEDITVTLDSVTELTPYIVRTLSVQRE----GCDDVRQVKQFHFTSWPDHGVPTSV--CNLLAFVRDSTRADP-------------
 |||||||..||| |.|.|||| |...|  |..||| |.        .  | |...|...|||||||..     .| ...   .|               
ekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllll

PGAGPMVVHCSAGVGRTGTFIVIDVMLQQIheEKTVDILGFVSTLRRHRNL-MVQTEQQYIFIHDALLDA
.. ||..||||||||||||..... ||...  |..||.|  |..||..|.  .||...||.|....||. 
dsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllel
0047943 (Phosphotyrosine protein) phosphatases II 29-277 9.7e-95 312.4 In-house 23-272 (273) alignment 
Range on Protein: 29-277
Range on HMM: 23-272/273.0
PVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLqdfeDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDK
......| ...| | |..|||| .|..||||||||    ...|||||||....||.. ...||.|||| .|. ||||||||||.|.|.|||.| |. | |
slkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrek

CAQYWPSRG---SLSYEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADPP--GAGPMVVHCSAGVGR
||||||. |   || |...|||| |...   |.|||| ... |....|.|..||.|.|||||||.|.  || |...  .|     . ||.||||||||||
caqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgR

TGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAI
|||||..|..|.|...|..||.|  |  ||..|  ||||..||.|...|||. .
tgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 30-278 1.7e-21 71.1 In-house 35-280 (303) alignment 
Range on Protein: 30-278
Range on HMM: 35-280/303.0
VPEHVTATHSLDpvNQHKNRYINIVAYDHSRVKLQDfedepgSDYINANFLPGYRRDNAyIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKC
.| .|.  . ..  | .|||.....  |||.||| |      | || |..|    . .| | .| ||. |. |||.|. ||. . ...|    |  .   
lppsvsknqfvk..nmdknrfvdvicldhskvklsd......ssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklgg

AQYWPS-RGSLSYEDITVTLDS---VTELTPYIVRTLSVQREgcDDVRQVKQFHFTSWPDHGVPTS----VCNLLAFVRDSTRADPPGAgPMVVHCSAGV
   .|  .  | .|. .. .     |     . .. |||     |    ..  |. .||   .|.     . . .  ..   |   ..  | |    .|.
dsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsng..dyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdst.ptvymslsgc

GRTGTFIVIDVMLQQIHEEK-TVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAII
||.||| ...     .|.|. ..|..  . ..|  |   ||   |. ...  | . ..
gragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 31-188 1.4e-18 61.4 In-house 83-235 (244) alignment 
Range on Protein: 31-188
Range on HMM: 83-235/244.0
PEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDfeDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERcrdkcA
|.      ...| | .|||    . .| .|| |       |  |||| |.    |   || .| |||.|  |||.|. |.    ...|  ..|       
pdpsvmkdafnpnnswknregaglpfdfnrvplsk..gsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....d

QYWPSRGSLSY--EDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGV
.|||    | .  |||||||    |.       | .. .  .  . .  |  . ||  | 
eywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgt
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 32-297 6.9e-88 289.8 In-house 13-275 (284) alignment 
Range on Protein: 32-297
Range on HMM: 13-275/284.0
EHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTnlkercRDKCAQ
.  . |..  . |. |||...|.|.|...|||.    | .|||||| |. ||.| . |||.|||| .|  |||||.||.|. ||..||      .|||.|
ngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsq

YWPSRGSLSYEDITVTLDSVTELTPYIVRTLSVQREG-CDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRD--STRADPPGAGPMVVHCSAGVGRTGTFI
||| ..   .|   | .|||.|   |.|| . . ..|   |.|...||||  |||.||| .  .|...|.     .    .  ..||||||||||||..|
ywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyi

VIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSASDLRSHIRRLQ
|.||.|....||| ||.  ||  ||. || .||   || ||. |||.  . | .. .  |. .....| 
vldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleels
subfamily_egg_pd Subfamily egg 32-274 2.4e-28 93.7 In-house 28-267 (307) alignment 
Range on Protein: 32-274
Range on HMM: 28-267/307.0
EHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERcrDKCAQ
.... |....  |..| |   .   | |||||.  .     |.| || . |    | .| || || .|  ||||||.... . |.|||  ||   ..|  
deislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..ercey

YWPSRGSLSYED----ITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRadppgagPMVVHCSAGVGRTGTF
|||   | |       . ..   | . .  . |   ..  | ||  .  .     .   .   |  ..|  .|. ..       |.||..  || ...|.
ywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgdvnnssdvysplrvlrklrnlsk.......pvvvqdilGvskaatl

IVIDVMLQQIHEEKT--VDILGFVSTLRRHRNLMVQTEQQYIFIHDALL
. |.. | ..    .    .|  |  ||..|.| |..  .|.|..  .|
vaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_PTPN12_pd Subfamily PTPN12 34-277 1.3e-79 262.2 In-house 30-277 (290) alignment 
Range on Protein: 34-277
Range on HMM: 30-277/290.0
VTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYW
......  ..|..|||| .|. ||.|||.|.  |.|.|||||||||. |   . .||||||||..|  |||||.||.| . ..|. .. |  . ||..||
ysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYW

PSRG--SLSYEDITVTLDSVTELT-PYIVRTLSVQREgcDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADPPGAGPMVVHCSAGVGRTGTFIVI
|..|  .| .....|||..   ..  ...||| |...  .. |.|.|||.|.|||||||.|. .||.....  .     . |.||||||||||||| |.|
peegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiai

DVMLQQIHEEKT---VDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAI
| . .....||.   .|.   | .||..|. .|||..|| ... |... .
dyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_PTPN3_pd Subfamily PTPN3 34-276 4.9e-73 240.5 In-house 31-274 (280) alignment 
Range on Protein: 34-276
Range on HMM: 31-274/280.0
VTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDepgsDYINANFL----PGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKC
.. ...  | | .|||| .|..||. ||||.. |     ||||||..    |.    | |||.|||||.|. |||.|||||.|..|.|||.| || | ||
laisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkC

AQYWPSRG-SLSYEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADPPGAGPMVVHCSAGVGRTGTFI
 ||||. . .|.| ...|.. .  | . |..| | ....  .. |.. |. ...|||||||..  ..| ||.   ..      |.|||||||.|||| .|
hqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvli

VIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDA
.... |. | ... | .|  |.|.|  |  .|||..|| |. .|.| .
lletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_PTPN1_pd Subfamily PTPN1 34-279 1.6e-66 218.9 In-house 22-273 (290) alignment 
Range on Protein: 34-279
Range on HMM: 22-273/290.0
VTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDepgsDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYW
...... .| |. .||| ..  |||||.||.. .     |||||...   . .  || .||||..|.  ||.|||||.|....|| .. |. . ||||||
fptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqyw

PSRGS---LSYEDIT--VTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFV---RDSTRAdPPGAGPMVVHCSAGVGRTG
|.  .   | .||..  |.| |  .   |.||.| ..   ... |.. .||.|.||| ||| |  ..| |.   |.|     .  || |.|||||.||.|
PqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGsl.ssdvGpavihcsaGiGrsG

TFIVIDVMLQQIHEEKT---VDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIIS
||...| .| .|....    |||   .  ||..|  ..|| .|  | . |.|. .  
tfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakv
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 34-277 5.5e-49 161.3 In-house 27-269 (281) alignment 
Range on Protein: 34-277
Range on HMM: 27-269/281.0
VTATHSLDPVNQHKNRYINIVAYDHSRVKLQD-FEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQY
  .|   .|||..||||.|| . | |||.|.  . ..  .||| ||..        || .|||  ||  |||||.|..|. .|.|| .. |  |.|||.|
dlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaey

WPSR--GSLSYEDITVTLDSVTELTPYIVRTLSVQREGcdDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDsTRADppgAGPMVVHCSAGVGRTGTFIVI
.|      | .. ..|. .  |     .   | .  ||  . | . .. .  |||  || |   .|  .|   ||    . | |.||||||||.||.. .
fprnahcclqfdklsvsyedstvnkslvttrlnlsyeg..etrlithwlwkewpdwqvpessevmlkilrk.irar...stppvihcsagvgrsgtlmav

DVMLQQIHEEKTV-DILGFVSTLRR-HRNLMVQTEQQYIFIHDALLDAI
.. || ||   |. ||   || ||   |   ||| |||..|   |||  
eialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfg
DSPc_SM00195 35-277 7e-92 302.8 In-house 17-262 (263) alignment 
Range on Protein: 35-277
Range on HMM: 17-262/263.0
TATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWP
. |..  . |..|||| ||. |||.||||.. |...||||||||.. |......|||.|||| .|..||||||||.....|.|||. .|... ||..|||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

SR--GSLSYEDITVTLDSVTELT-PYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVP---TSVCNLLAFVRDSTRADppgAGPMVVHCSAGVGRTGTFI
.   |.  ...|.|.| .|..    .|.|||... ||... |.|.|.....|||||||   .|| .|| .|. |..      ||.||||||||||||||.
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...sgpivVhCsaGvgRtgtfv

VIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAI
.||..|....|||.|||   |. || .|  ||||..||.||..|.|..|
tidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 35-277 7e-92 302.8 In-house 17-262 (263) alignment 
Range on Protein: 35-277
Range on HMM: 17-262/263.0
TATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWP
. |..  . |..|||| ||. |||.||||.. |...||||||||.. |......|||.|||| .|..||||||||.....|.|||. .|... ||..|||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

SR--GSLSYEDITVTLDSVTELT-PYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVP---TSVCNLLAFVRDSTRADppgAGPMVVHCSAGVGRTGTFI
.   |.  ...|.|.| .|..    .|.|||... ||... |.|.|.....|||||||   .|| .|| .|. |..      ||.||||||||||||||.
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...sgpivVhCsaGvgRtgtfv

VIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAI
.||..|....|||.|||   |. || .|  ||||..||.||..|.|..|
tidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPRN_pd Subfamily PTPRN 35-274 6.1e-59 194.1 In-house 47-289 (297) alignment 
Range on Protein: 35-274
Range on HMM: 47-289/297.0
TATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPG-YRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYW
|.. . .. | .|||. ....||||||||..  ..  |||||| ..     |  ||||.|||||.|  |||.||||| .  |..||.|.|    .|..||
tkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckryw

PSRGSLSYEDITVTLDSVTE-LTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADPPGAGPMVVHCSAGVGRTGTFIVIDV
|  ||  |.   | | |       |.||.. ..    .. | | |||| |||..|||.|  .|| | |   ..    . |.|||||.|.||||..|.||.
pdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidl

MLQQIHE-EKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALL
.|...    | .||   .  ||  |. .|.|..|. |.  |. 
vlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltava
0040439 (Phosphotyrosine protein) phosphatases II 37-277 1.6e-88 291.8 In-house 4-246 (249) alignment 
Range on Protein: 37-277
Range on HMM: 4-246/249.0
THSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSR
...| |.|..|||| .|..||||||||..... ..||||||....||.. ...||.|||| ||. |||||.||.....|.|||.|.|. | |||||||..
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplg

GSLSYEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTR--ADPPGAGPMVVHCSAGVGRTGTFIVIDVML
||| |.|.|||| ||...  |.|||| ... .....|.|.....|.||||||| |.  ||.|..      .. |  ||..||||||||||||||... ||
gsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylml

QQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAI
.|...|..||..  |..||..|. .||...||.|...|||. .
eqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 37-268 1.1e-31 104.8 In-house 43-272 (301) alignment 
Range on Protein: 37-268
Range on HMM: 43-272/301.0
THSLDPVNQHKNRYINIVAYDHSRVKLQDfedEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSR
|.|.  ....|.|| ..    .. |.. .   .     | ||..|   . . .||.|||| .|. ||| |.   .  .|.||..  |.  .||..| |..
tesyaylpkdkhryptvPckPstaveviv...dGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvk

GS--LSYEDITVTLDSVTEL--TPYIVRTLSVQRE-GCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADPpgagPMVVHCSAGVGRTGTFIVID
 |  |  .  .... .   .     . ||| |.   |  . | |  . ...|.|.||| |  .|  ..    ...     |.|||||||.||. .||  .
isekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek....PivvhcsaGiGrsvafigte

VMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIF
.. .... ..|...   .  || ||   |||..|  .
ylareveadptieltealkhlrehrwngvqtnsqlyw
0042113 (Phosphotyrosine protein) phosphatases II 38-275 7.7e-88 289.3 In-house 3-241 (245) alignment 
Range on Protein: 38-275
Range on HMM: 3-241/245.0
HSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRG
..| |.|..|||| .|..|||.||||.. . ...||||||.. .|||. . .||.||||.||. |||||.||....||.|||.. |. | |||||||...
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplge

SLSYEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADP-PGAGPMVVHCSAGVGRTGTFIVIDVMLQQ
|| |.|.|||| |.. |  |.||||.|...|.| .|.| ..|...|||||||...  || |..   .|   .. ||..||||||||||||||... ||.|
sltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleq

IHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLD
...|..|..   |  ||..|  .|||..||.|...|||.
lekelgvsleeavkelrsqRpgavqtpsqyrflyealle
0037934 (Phosphotyrosine protein) phosphatases II 38-275 1.5e-79 262.2 In-house 4-240 (243) alignment 
Range on Protein: 38-275
Range on HMM: 4-240/243.0
HSLDPVNQHKNRYINIVAYDHSRVKLqdfedePGSDYINANFLPGYRRdnaYIAAQGPLAETCRD----FWRMVWEQNSRTIIMLTNLKERCRDKCAQYW
..| |.|..|||| .|..||||||||      .||||||||. ....|   .|| |||| ||. |    ||||.||.....|.|||.|.|. | ||||||
iallpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PsrGSLSYEDITVTLDSVTELTPYIVRTLSVQREG-CDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRA--------DPPGAGPMVVHCSAGVGRT
|  |.  |.|.|||| |...|  |.||||.... .  | .|.| ..|...|||||||.|. .||.|... .            .. ||..||||||||||
p..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRt

GTFIVIDVMLQQIheekTVDILGFVSTLRRHRNL-MVQTEQQYIFIHDALLD
||.|....||...    .||..  | .||..|.  .|||..||.|...||| 
Gtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 40-281 5.9e-41 135.1 In-house 51-293 (305) alignment 
Range on Protein: 40-281
Range on HMM: 51-293/305.0
LDPVNQHKNRYINIVAYDHSRVKLQDFEdepGSDYINANFLPG-YRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPS-RG
   ... |||| .. . |.| |||..      |||| ||..      .. .|.||||| .|  .|| || ...   |.|| .  |  . |||||||  .|
sadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqg

SLSYEDITVTLDSVTELTP-----YI-VRTLSVQREGcDDVRQVKQFHFTSWPDHGVPTSVC---NLLAFVRDStradppgAGPMVVHCSAGVGRTGTFI
        . .. |.   |      | . .| .   | |.   |.....| ||| |||       .||. .| |         |.|||||||.||||| .
eklelksgivvenvsgskpmerdaeiqitllnltysg.dqkmsvrhlqwtewpdrgvppckltslellsairgs.......kvpivvhcsagigrtgtiv

VIDVMLQQIHEEKTVD-ILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGE
 |. .|..| |.| .  .  .| .|| .|   .|.. ||.|||  .|. ..   
aieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfleky
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 41-279 9.8e-87 285.3 In-house 6-244 (250) alignment 
Range on Protein: 41-279
Range on HMM: 6-244/250.0
DPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDkCAQYWPSRGSLS
.| |..|||| .|.|.|.||| |.  . .  |||||| || ||.  .|.||.|||| .|  ||||||.|..| ||.|||||||  .  . ||||  ..  
kpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaek

YEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADPP-GAGPMVVHCSAGVGRTGTFIVIDVMLQQIHE
| |.||.| |  | . |..|.| . ..   | |.|.|.||..||| |||      |.....  . ..  |..|..|.|||||||.|.||.|| .|.....
yGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkk

EKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIIS
||.||.  .. .||..|  .|....||.|.. ..| |. |
ekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 41-274 1.5e-61 202.7 In-house 35-274 (287) alignment 
Range on Protein: 41-274
Range on HMM: 35-274/287.0
DPVNQHKNRYINIVAYDHSRVKLQdFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRG-SL
.  . .|||| ... .|..|| |   | | ||||||||....|..|.|.||||||.| | |||||.|.|..| ..|..|   | .| || .||| |   .
elaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPm

SYEDITVTLDSVTELTP-YIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDS-----TRADPPGAGPMVVHCSAGVGRTGTFIVIDVM
     .|.| . . . | | ||.| .      . | |||... ||||.... .   |. || |       . |  ..||.|||...|.||.|... . |.
rvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvl

LQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALL
...  .   ||.   |  || .|. .||.  |. .. .|| 
vsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 41-279 6e-32 105.7 In-house 32-272 (285) alignment 
Range on Protein: 41-279
Range on HMM: 32-272/285.0
DPVNQHKNRYINIVAYDHSRVKLQDFEdepgSDYINANFLPGYRR-DNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGS-
   |   ||| .. . . .|| |....     ||| |...    . ...||..|||| ||  |||.|.....   ..||  | |   .||| |.| .   
yeanpdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

-LSYEDITVTLD--SVTELTPYIVRTLSVQR--EGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADPpGAGPMVVHCSAGVGRTGTFIVIDVM
 . .    .||       ..  |. .|.|    . . .   ... .   |||.  |     .. . .   . .|    |..|||||||||| ||. ||  
vvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnp.kekpicvhcsagvgrtatfvgidya

LQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIIS
  .| |.  ...|  |  .|  |   ||.  |..|..  |.. .| 
tirimenpniemldivremramrfqavqshmqflflyvvlmeyfig
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 43-276 5.5e-75 246.6 In-house 6-239 (239) alignment 
Range on Protein: 43-276
Range on HMM: 6-239/239.0
VNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRR-DNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGSlSY
||. |||| |||.|||||| |. . ..| ||||||..|  |    .||||.|| .. .. |||||.|..    |.||| | |  . || ||||   |  |
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.ky

EDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEK
 .. |||     .. ||.||. . . |  . | | |.||| |||.|||     .| . |  |.   ||| | |.||||||||||.|.||| ||.| ...|
cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqk

TVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDA
||||. .| ..|  |  |||| .||.||| |.|.|
tvdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 43-274 1.5e-74 245.2 In-house 7-238 (239) alignment 
Range on Protein: 43-274
Range on HMM: 7-238/239.0
VNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRR-DNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGSlSY
||. |||| |||.|||||| |. . ..| ||||||..|  |    .||||.|| .. .. |||||.|..    |.||| | |  . || ||||   |  |
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.ky

EDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEK
 .. |||     .. ||.||. . . |  . | | |.||| |||.|||     .| . |  |.   ||| | |.||||||||||.|.||| ||.| ...|
cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqk

TVDILGFVSTLRRHRNLMVQTEQQYIFIHDALL
||||. .| ..|  |  |||| .||.||| |.|
tvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_PTPN13_pd Subfamily PTPN13 43-276 1.1e-70 233.0 In-house 36-268 (273) alignment 
Range on Protein: 43-276
Range on HMM: 36-268/273.0
VNQHKNRYINIVAYDHSRVKLQDfedEPGsdYINANFLPGYRRD--NAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGS--
 |..|||| |.. ||..||||.|   | |  ||||...     .    |||.|||| ||..|||.|||||... |.|.|. ||. . || .|||.. .  
enkdknryrnvlPydetrvklgd...egg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkk

LS-YEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADPpGAGPMVVHCSAGVGRTGTFIVIDVMLQQI
|  .. ..|.|  |..|  . ||.| |.     ..|.| ...|..|||||||.|  .|| ||.   | .   |||.|||||||.||.||.|.|||.|. |
lkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitidvvlgli

HEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDA
. .| .|.   | .||. |. .|||..||||.. |.|..
erdkefdvkeivrklreqrqgvvqtkdqyifvykailev
subfamily_PTPN23_pd Subfamily PTPN23 43-276 1.6e-63 209.3 In-house 42-279 (288) alignment 
Range on Protein: 43-276
Range on HMM: 42-279/288.0
VNQHKNRYINIVAYDHSRVKLQDFEDepgsDYINANFLPGYRRD-NAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRG--SL
.. .|||. .|. |||.||||.. .|    ||||| |. .       .||.|.||..|  |||.||.|| |..|.||.. .|. . |...|||..   . 
lyseknrsrdilPyDhnRvklrgskD....DYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetv

SYEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTR----ADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQ
...|..||| ||.|. ... |.|... .. | |..|.  ..||||..||| |  .||.|.            .   |.||||||||||||.| ..   ..
kfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavr

QIHEEKT-VDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDA
......  .||.  ||.||. |  |||...|. |  .| | |
elekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 43-286 7.5e-45 148.2 In-house 40-286 (307) alignment 
Range on Protein: 43-286
Range on HMM: 40-286/307.0
VNQHKNRYINIVAYDHSRVKLQdFeDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRG--SLS
 |..|||| .. . |..|. .. | |   |||| ||.|    . . .|.||||| .|  .|| |. ...  ..||| .. | .. || ||||      | 
antdknryqdvkcqdkgrivvk.f.dglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklv

YE----DITVTLDSVTELTPY--IVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVrDSTRADppgAGPMVVHCSAGVGRTGTFIVIDVML
.      |.|.   . .|.|   ..   ... . ... | .... .. |||.|||    . . .. ...| |     |.||||||||||.|| . | .. 
fgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainll.eavryd...tnpvvvhcsaGvGrsGtivaislvq

-QQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSA
 . |  .   |.  .|  || .|.  .||| ||...|  ||.  .    || .
dkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyketye
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 43-289 1.8e-38 126.8 In-house 51-301 (310) alignment 
Range on Protein: 43-289
Range on HMM: 51-301/310.0
VNQHKNRYINIVAYDHSRVKLQdFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGSL-SY
 . ||||| ..|  | |||||.  .     ||| ||..      ...| .||||  |  |||||.... . .|..| .  |  | ||  |||| |   .|
kymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtety

EDITVTL--DSVTEL-----T-PYIVRTLSVQREGCD-DVRQVKQFHFTSWPDHGVPTSVCNLLAfvrDSTRADpPGAGPMVVHCSAGVGRTGTFIVIDV
  | ||   .|  |.     .  ..   . |. . .. .  .|.  ..  ||| |||   |  .    .   |.    || |||||||..|... . ...
gcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp...qrllaq.vrhgpcvvhcsagkdrlyvvvalkl

MLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLdAIISGETETSASDL
 ...... . ||.   .. |...|   .||| ||..|.   . ..  ||||.. . |
kidkldrglkvdaeevktellksraiciqtelqyliidrvri.ifargetevaekil
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 43-194 2.7e-12 39.9 In-house 26-160 (169) alignment 
Range on Protein: 43-194
Range on HMM: 26-160/169.0
VNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINAnflpgyrrdnayiaaqgplaetcrdfwRMVWEQNSRTIIMLTNLKERCR----DKCAQYWPS--R
.|. |||    .|  | |||||   .. |||||||                           ||.|| |.  |..| .  ..       .  |  |.   
cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddknnfwpekedyqlhpavil

GSLSYEDITVTLDSVTELTPY---IVRTLSVQREGCDDVR-QVKQFHFTSWPDHGVPTSVCN
|    . . |  | |. .|     ..    |  .  |||  ... .|...||. ||| |  .
gewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqspvh
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 43-194 1.7e-11 37.2 In-house 25-159 (169) alignment 
Range on Protein: 43-194
Range on HMM: 25-159/169.0
VNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINAnflpgyrrdnayiaaqgplaetcrdfwRMVWEQNSRTIIMLTNLKERCR----DKCAQYWPS--R
.|. |||    .|  | |||||   .. |||||||                           ||.|| |.  |..| .  ..       .  |  |.   
cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddknnfwpekedyqlhpavil

GSLSYEDITVTLDSVTELTPYI---VRTLSVQREGCDDVRQ-VKQFHFTSWPDHGVPTSVCN
|    . . |  | |.  |  .   .    |  .  ||| . .. .|...||. ||| |  .
Gewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspvh
Y_phosphatase Protein-tyrosine phosphatase 44-274 1.7e-88 291.4 Pfam-A 1-234 (235) alignment 
Range on Protein: 44-274
Range on HMM: 1-234/235.0
NQHKNRYINIVAYDHSRVKLqdfEDEPG-SDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWP--SRGSLS
|..|||| .|..||..||||   ....| |||||||.. ||......||.|||| .|. |||||||......|.|||.|.|. | |||||||  ...||.
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YEDITVTLD-SVT-ELTPYIVRTLSVQREGCDD-VRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQI
|.||.|.|  ... . . |..|.|... .. ..  |.|||.|.|.|||||||.|. .|| ..|.  .   .  ||.||||||||||||||...|..|.|.
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

HEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALL
..|..||.| .|..||..|. |||...||||...|.|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 44-274 1.7e-88 291.4 In-house 1-234 (235) alignment 
Range on Protein: 44-274
Range on HMM: 1-234/235.0
NQHKNRYINIVAYDHSRVKLqdfEDEPG-SDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWP--SRGSLS
|..|||| .|..||..||||   ....| |||||||.. ||......||.|||| .|. |||||||......|.|||.|.|. | |||||||  ...||.
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YEDITVTLD-SVT-ELTPYIVRTLSVQREGCDD-VRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQI
|.||.|.|  ... . . |..|.|... .. ..  |.|||.|.|.|||||||.|. .|| ..|.  .   .  ||.||||||||||||||...|..|.|.
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

HEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALL
..|..||.| .|..||..|. |||...||||...|.|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 44-274 6.1e-70 230.1 In-house 3-236 (237) alignment 
Range on Protein: 44-274
Range on HMM: 3-236/237.0
NQHKNRYINIVAYDHSRVKLQDFEDEpgSDYINANFLPGYRR-DNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRG-SLSY
|. |||| |||||||||| |.    .  ||||||..| |.    . ||||||||  .| |||.|||...   |.||| | |. . || .||||     .|
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

EDITVTLDSVTELTPYIVRTLSVQR-EGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADP--PGAGPMVVHCSAGVGRTGTFIVIDVMLQQIH
  .||.|    |.. | ||.| ...     .|| ..|..||||||.|||   . || | ..     |  . .|| ..|||||||||| |.||| ||.| .
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

EEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALL
|.| |||  .| ..   |  ..||..||.|||...|
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 44-274 4.8e-68 224.1 In-house 20-261 (270) alignment 
Range on Protein: 44-274
Range on HMM: 20-261/270.0
NQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYR-RDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRG----S
... ||| .|.   ..||.|.. |... . |||||...|.  ....||||.|||. | ..||||.||.....|.|.|.|.|. |.||..|||..     .
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

LSYEDITVTLDSVTELTPYIVRTLSVQREGcdDVRQVKQFHFTSWPDHGVPTSVC------NLLAFVRDS--TRADPPGAGPMVVHCSAGVGRTGTFIVI
|.. .|.|.  | .  . ||.. | ....|  . |..  |....|||||||..        .||. .|.   .. .   |.|..||||||||||||.|..
ledgkikvlalseekeegyiltrlrleekg..eerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlial

DVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALL
| ... ..|.| ||.|  .. ||..|  .||. .|| |.. |..
DiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavv
0041856 (Phosphotyrosine protein) phosphatases II 44-281 4.4e-55 181.4 In-house 1-175 (182) alignment 
Range on Protein: 44-281
Range on HMM: 1-175/182.0
NQHKNRYINIVAYDHSRvklqdfedepGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTnlkercrdkCAQYWPSRGslsyed
|..|||| .|. |||||          ..||||||.. |..... .||.|||| .|. ||.||..|.. .||..||         . .|||..       
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

itvtldsvteltpyivrtlsvqregcddVRQVKQFHFTSWPDHGVPTsVCNLLAFVRDSTRadppGAGPMVVHCSAGVGRTGTFIVIDVMLQQiheekTV
                             |.. |.....|||||||. .  ||.|...  .      || .||||||||||||......|...      |
............................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gv

DILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGE
..   |...|..|. ||.|..||.|...|||. .  ..
sleeavklvrsrRpgmvitpnqyfflqlallellllkk
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 44-276 5.3e-45 148.4 In-house 48-286 (305) alignment 
Range on Protein: 44-276
Range on HMM: 48-286/305.0
NQHKNRYINIVAYDHSRVKLqdfEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRG--SLSY
...|||| ..   |. ||||   |     .|| ||..      . .| .| || .|| ||| | ....  .|.|| ||.|.   ||..|..|.    |..
eagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlef

E----DITVTLDSVTEL------TPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDStRadpPGAGPMVVHCSAGVGRTGTFIVID
|     |.| ..| ..|         . .|  |      ..|.|...|.  ||| |||..   .| .. .. |   |  ||.|||||||.||||. ....
eekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka.r...pskgpivvhcsagigrtgsvvmle

VMLQQIHEEKTVDI-LGFVSTLRRHRNLMVQTEQQYIFIHDALLDA
 .|.|. . . ..     .  .|  ||  .||..||.|.|. .|. 
yildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilny
subfamily_ptpA1_pd Subfamily ptpA1 44-238 7.1e-39 128.7 In-house 47-257 (418) alignment 
Range on Protein: 44-238
Range on HMM: 47-257/418.0
NQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRrDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSR-------
|  |||| ||.  .|.||.|.  .|. ||||||||.. |    . .|..|||| .|  ||||||||.  | |.||.   | || || .||| .       
ntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfs

----GSLSYEDITVTLDSVTELT--PYIVRTLSVQREGcdDVRQVKQFHFTSWPDHGVPTSVCN---LLAFVRDSTRADPP---GAGPMVVHCSAGVGRT
    |   .   .| |  | .      | | . .  ||  . |.. |...  |||| .|        ||  . .      |      |..||||||||||
iygngnevfgtysvelveviqdpereiitrnirltfeg..etrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrt

GTFIVIDVMLQQIH
|||    .|.... 
gtfctavimmkkld
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 44-278 2.3e-38 126.9 In-house 43-272 (288) alignment 
Range on Protein: 44-278
Range on HMM: 43-272/288.0
NQHKNRYINIVAYDHSRVKLQdfeDEPgSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGSLS---
|  ..|| |.   | .||||.   |.|   ||.|| ..  . ..  | || ||  |   .|.|. |.. . |.||..| |. ..| |.|.||.   .   
nptrdryenlprcditrvkls...ddp.dfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

YEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVrdsTRAdPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEE
    ||. .. ...   .. .|    .  ..   ||. |.  |.|.||| .    | ..   ..       |.|||.|||||||||.|.| ..|...  .
grlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrll...evl.kslqkPivvhssaGvGrtgtlililialeslrld

KTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAII
  . |  ... || .|   .|||.||...|  .|. ..
dflgirsllaklreerfkaiqtemqylyvhrcvleell
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 44-198 2.1e-37 123.6 In-house 33-189 (297) alignment 
Range on Protein: 44-198
Range on HMM: 33-189/297.0
NQHKNRYINIVAYDHSRVKLQDfeDEPGSDYINANFL--PGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSR--GSL
  .|||| .|.|.| .||||.     ...|||||...  |    |  || ||||| .|  |||..|.||. |.|.|...|.|  ||||| ||||   . |
slrknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerl

SYEDITVTLDSVTE--LTPYIVRTLSVQREgcDDVRQVKQFHFTSWPDHGVPTSVCNLLAF
   |. |   | |       |.  | .     .. |.|.   | ||||||||. . .|  |
kagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrf
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 44-274 1e-20 68.4 In-house 51-282 (302) alignment 
Range on Protein: 44-274
Range on HMM: 51-282/302.0
NQHKNRYINIVAYDHSRVKLQDFEDepgsDYINANFL--PGYRrdNAYIAAQGPLAETC---RDFWRMVWEQNSRTIIMLTNlKERCRDKCAQYWP--SR
| .||.  .. ..|. .|||.  .|    .|.||  .  |  .  .  | || |  ..     .|||||....  .. .|   .| .     ...|  | 
nlkknqsedvpildsnlvkleaepd....syvnaskvevPelt..rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvg.eeelkktlselfpkksg

GSLSYEDITVTLDSVTELTPYI-VRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQ
  . |... |    | .        .. |  ||| .   ..  ..| |... ||... .| . . .    . ..  ..|.    |.|| |.|..  | ..
dykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavave

QIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALL
.....| . |   | ..|  |  .|.. .||.... |||
klqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_eak_pd Subfamily eak 44-197 1e-13 45.4 In-house 52-202 (332) alignment 
Range on Protein: 44-197
Range on HMM: 52-202/332.0
NQHKNrYINIVAYDHSRVKLQDFEDEPgSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRG--SLSY
. ..|  ..|| ||.  |.|     ..   ||||  .      . || .  .  .    ||.|| ||.| .|..| .  |   .|  .|.| ..   |..
avnrn.vvkivpydrylvrltssqlnr.lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkf

EDITVTLDSVTELTPYIVRTLSVQReGcDDVRQVKQFHFTSWPDHGVPTsVCNLLA
  . |.  .  .   . .| | ... | ..  .|. ...  | .  .|  . ..||
Gildverkefvkrniletrllelsk.G.nethrvlhykvfGwtettlpk.yedfla
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 44-130 8.6e-12 39.2 In-house 34-119 (332) alignment 
Range on Protein: 44-130
Range on HMM: 34-119/332.0
NQHKNRYINIVAYDHSRVKLQDFEdePGSDYINANFLPGYRRDNAYIAAQGPLAE-TCRDFWRMVWEQNSRTIIMLTNLKERCRDKCA
|   ||   . ..|||||.|   .     |. ||... || . .||| || |. . |   ||||| |..   |... .. |. . |. 
nmdmnriphlycfdhsrvelapqd..gkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkap
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 45-275 2.1e-50 166.0 In-house 57-281 (290) alignment 
Range on Protein: 45-275
Range on HMM: 57-281/290.0
QHKNRYINIVAYDHSRVKLQDFEDepgSDYINANFLPGYRrdNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRG--SLSYE
 .|||| ..|  | .|| |.|  |    ||. ||.. | .    .| .||.|..|  |.|||| ...  .|.|| .| |  . ||.||.| .    |.. 
fkknrykdvvcndktrvilkdGyd...GdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfG

DITVTLDSVT-ELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRAdppgAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEK
.|||.    . . .  | .||||.        ..| ..  ||||. |. |   ||  .|   .|    .||.|||||||.||||||. |.| || . . |
eitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka....sGpvvvhcsaGiGrtGtfvaievglqilldGk

TVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLD
 .|.|. | .||. |   || . ||. . ..|||
eldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 46-153 2.7e-25 83.8 In-house 49-167 (350) alignment 
Range on Protein: 46-153
Range on HMM: 49-167/350.0
HKNRYINIVAYDHSRVKLQDF--------EDEPGSDYINANFLPG----YRRDN--AYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQ
 |||| ||. |.||||||.              ..||||||.|       . .    |||.|.|| .|  ||.... . . . |..||.. |  ..|| .
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPSrgsLSYEDITVTLDSVTE
||.    .||.|||| | |  |
YWqe...gsydditvklaskwe
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 46-153 2.5e-16 53.9 In-house 50-170 (349) alignment 
Range on Protein: 46-153
Range on HMM: 50-170/349.0
HKNRYINIVAYDHSRVKLQDFEDEPG--------------SDYINANFL--PGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKC
 |||| .|. |.||||||.     .                ||||||.|  . .  .. ||| | ||  |  ||....  .. . .. |.. ||   .||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

AQYWPsrgSLSYEDITVTLDSVTE
 .||     |||..||| |    .
diywq...elsysnitvklqnssl
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 46-117 4.2e-07 23.8 In-house 39-115 (347) alignment 
Range on Protein: 46-117
Range on HMM: 39-115/347.0
HKNRYINIVAYDHSRVKLQDFE-----DEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIM
 |||  .    | .|| |   .      ..   ||||  .     .. || .| || .| ||||.||   .   .. 
sknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 47-279 7.2e-32 105.3 In-house 46-278 (312) alignment 
Range on Protein: 47-279
Range on HMM: 46-278/312.0
KNRYINIVAYDHSRVKLQDFEdepgSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPS-RGSLSYEDIT
 ||| ||  .|  |  |   |      || |||.    . . ....|||| .||  ||...    | .||.|. . |   .|||.|     | .  ||  
lnrypniqcwdrgrftlagde....nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhr

VTLDSVTELT-------PYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSvCNLLAFVRDSTRADppgAGPMVVHCSAGVGRTGTFIVIDVMLQQIH
|  ...||.            | | |      .  ..... ..||||||.| | |.    .  . . |     |.. |||||||||||...|. |.  . 
vyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpds.cdtalrllsavkkd...kkpviahcsagvgrtgtlaliesmiaalr

EEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIIS
  .  ..      ||. |   |..  ||..   ..|. . |
hprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflys
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 47-278 6.3e-23 76.3 In-house 22-260 (290) alignment 
Range on Protein: 47-278
Range on HMM: 22-260/290.0
KNRYiNIVAYDHSRVKLQDFEDEPGSDYINANFLpGYRRDNAYIAAQGPLAET-------CRDFWRMVWEQNSRTIIMLTNLKERCRD----KCAQYWPS
..|. ..    ..|| |...     .||| ||..  .  . . |. | |....         .|| |. . ... ..|| . .|....     ||.| | 
dqRl.evpLveatrvvLkgygkrfnddyiHAnrv.tcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpe

R--GSLSYEDITVTLDSVTELTPYIVRTLSVQREGCDDVrQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRAdppgAGPMVVHCSAGVGRTGTFIVIDVM
.  ..| ....||   |  .    ..|.| |. ..  .  .|.   . .| .  |. .   ||. ..           |..|||  |. |  ..  |.. 
svgeelkfkgltvkCkskekeddvetRelvvkfddeeef.tvtHsllkgWnklnvqedtktllsliqkvkas....ktpvivHcvdGiSrsAalaaiilg

LQQIH-EEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAII
 | |   .. | .   ...||..|.|........ |.  ...  .|
yQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllai
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 55-188 3.3e-12 40.9 In-house 4-126 (130) alignment 
Range on Protein: 55-188
Range on HMM: 4-126/130.0
AYDHSRVKlqdfedepGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERcrdkcAQYWPSRGSLS-Y-EDITVTLDSVT
 .. ||..        | .||||.|.    | . |. .| |||.|. |||.|. |.    ...|  ..|       .|||    |  | |||.|||    
efevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdrd

ELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGV
|        | ....  .  . .  |. . ||  | 
efknikasnleiesdlneshqaltmfqisnwpsdgt
0044763 (Phosphotyrosine protein) phosphatases II 56-272 7.1e-39 128.6 In-house 2-166 (178) alignment 
Range on Protein: 56-272
Range on HMM: 2-166/178.0
YDHSRVKLQDFEDEPGSDYINANFLPGYrrdnAYIAAQGPlaetcRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGSlsyeditvtldsvtelt
.|..||.|. .|....||||||..  ..     |.....|      |......|.. ..|..||. .|. . || .|||.. .                 
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

pyivrtlsvqregcddvrqvKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQiheekTVDILGFVSTLRRH
                     |.... .||||||..   .|.||.   .| ..  || .|||||||||.||..... |...      ...   .. .|..
....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrer

RNlMVQTEQQYIFIHDA
|. .|... |. .... 
Rp.ivpnpgqlrqLyef
0046846 (Phosphotyrosine protein) phosphatases II 67-273 8.5e-46 151.2 In-house 7-169 (176) alignment 
Range on Protein: 67-273
Range on HMM: 7-169/176.0
EDEPGSDYINANFLPGYRrdnaYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGSLSYeditvtldsvteltpyivrtlsvqr
 .....||||||.. |.|    .|| |||| .|. ||..|..|.. .....||...|  | ||..|||   .|..                         
gldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.........................

egcddvrqvkQFHFTSWPDHGVPTSvCNLLAFVRDSTRADPPGaGPMVVHCSAGVGRTGTFIVIDVMLQqiheEKTVDILGFVSTLRRHRN-LMVQTEQQ
          |.... |||||||..   || ...   .|   | || .||||||.|||||..... .      || ....  ....|..|   .|||..|
..........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpeQ

YIFIHDAL
| |.....
yrflyefe
0043147 (Phosphotyrosine protein) phosphatases II 69-270 6.5e-46 151.5 In-house 2-154 (172) alignment 
Range on Protein: 69-270
Range on HMM: 2-154/172.0
EPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLkercrdkcaqywpsrgslsyeditvtldsvteltpyivrtlsvQREG
..|||||||..|..|.  . .|| |||| .|. |||||..|.. ..|..||.|                                           .  .
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydp

CDDVRQVKQFHFTSWPDHGVPtSVCNLLAFVRDSTR--ADPPGaGPMVVHCSAGVGRTGTFIVIDVMLqqiheeKTVDILGFVSTLRRHRNLMVQTEQQY
 . .|.. |.....||||||| .   || |..   .  |  || ||..||||||||||||..... ||      . ....  |...|..|. .||...||
ellerlgiqylylpwpDhgvp.llellleflefidellalspg.gpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqy

IFIH
.|..
rfly
0051429 (Phosphotyrosine protein) phosphatases II 70-297 1.2e-59 197.4 In-house 2-244 (272) alignment 
Range on Protein: 70-297
Range on HMM: 2-244/272.0
PGSDYINANFLPGYRR---DNAYIAAQGPLAETCRDFWRMvWEQNSRTIIMLTNLKERCRDKCAQYWP------------SRGSLSYEDITVTLDSVTEL
| |.||||....|| |   ........|||  |..||||. .|.. .||..|... || |.|| .|||            |  . .| ...||| |.. |
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

TPYIVRTLSVQRE-GCDDVRQVKQFHFTSWPDHGVP-TSVCNLLAFVRDstradppgAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVD--------
. ||.|.| . .. . ...|.| ..|.|.|||||||  ....||....|         ||..||||||..||||..... .|.....|  ||        
ldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

ILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAiISGETETSASDLRSHIRRLQ
....|. ||..|  .||||.||.|...|||.. . . ....|. |..... ..
leeaveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaaldaid
0036282 (Phosphotyrosine protein) phosphatases II 71-271 7.9e-51 167.5 In-house 1-164 (174) alignment 
Range on Protein: 71-271
Range on HMM: 1-164/174.0
GSDYINANFLPGYRRDNAYIAAQGPLAetcrdFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSrgslsyeditvtldsvteltpyivrtlsvqrEGCD
|||||||..| .... . .|| |||||     ||.|..|....|..||...||. . || .|||.                                  |
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lred

DVRQVKQFHFTSWPDHGVPTSVCnLLAFVRDSTRADPP-GAGPMVVHCSAGVGRTGTFIVIDVMLQQIHeEKTVDILGFVSTLRRHRNLMVQTEQQYIFI
 .| . |.... |||||||..   || ||.   .|    . ||..||||||||||||..... ||.... |..||.| .| .||..|  ||||..||.|.
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

HD
..
yy
0051082 (Phosphotyrosine protein) phosphatases II 71-273 4.1e-38 125.6 In-house 2-149 (151) alignment 
Range on Protein: 71-273
Range on HMM: 2-149/151.0
GSDYINANFLPGYrrdnaYIAAQGPLAetcrDFWRMVWEQNSRTIIMLTNLKERCrdKCAQYWPSRGslsyeditvtldsvteltpyivrtlsvqregcd
 |||||.... |.     ... .||||    ||.....|.. .||..|....||   .|..|.|. |                                 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

dvRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRadpPGAGPMVVHCSAGVGRTGTFIVIDVMLQQiheektVDILGFVSTLRRHRNLMVQTEQQYIFIH
  ..|.......|||.|.|.|   .|.|..   .   .. ||..||||||.|||||..... ||..      |..   .. .|..|  .||..||..|..
..ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

DAL
 ||
fal
0049260 (Phosphotyrosine protein) phosphatases II 79-271 1e-43 144.0 In-house 1-144 (152) alignment 
Range on Protein: 79-271
Range on HMM: 1-144/152.0
FLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWpsrgslsyeditvtldsvteltpyivrtlsvqregcddvrqvkQF
|..||.. ...||.|||. .|. |||||..|.. .||.|||.| |. ..||.||.                                           |.
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

HFTSWPDHGVPTSVCNLLAFVRDSTRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLqqiheeKTVDILGFVSTLRRHRNLMVQTEQQYIFIHD
... |||||||..   || ...   ..     || .||||||||||||..... ||      . |... .|. .|..|. .|....|..|...
lhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 81-174 2.3e-13 44.3 In-house 230-322 (440) alignment 
Range on Protein: 81-174
Range on HMM: 230-322/440.0
PGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCrdkCAQYWPSR-GSLSYEDITVTLDSVTELTPYIVRTLSVQ-REGCDDVRQ
 || . ||.||.| ||  |  ||||.| . .  ||||| .|...    |. |||    |...  .||      ..    |||| .. .|   ..||
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndkt...csiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevheirq
subfamily_hpo-7_pd Subfamily hpo-7 85-286 8.6e-19 62.4 In-house 36-236 (263) alignment 
Range on Protein: 85-286
Range on HMM: 36-236/263.0
RDNAYIAaqgpLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSR--GSLSYEDITVTLDSVTEltPYIVRTLSVQR--EGCDDVRQVKQFHF
| | |.     | .|   |....  ... ...||.. .|  ..|| .|.|    . . .....|.   | .    ...|| .    .    ...||.. .
rknlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysy

TSWPDHGVPTS---VCNLLAFVRDStRadppgagPMVVHCSAGVGRTGTFIVIDVMLQ----QIHEEKTVDI--LGFVSTLRRHRNLMVQTEQQYIFIHD
. |...  |.    . |.|  .|.| .       ..|||||.|.||.  | |.... |    .... .||..  | ..  || .|.  ..|  |  |   
kgWiekndpelareilnilkvarns.k.......slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsil

ALLDAIISGETETSA
 .|| ..   ..  .
mvLdfvlnnfakgel
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 86-270 3.6e-25 83.3 In-house 4-197 (199) alignment 
Range on Protein: 86-270
Range on HMM: 4-197/199.0
DNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSR--GSLSYEDITVTLDSVTELTPYIVRTLSVQRE--GCDDVRQVKQFHFT
.  |||.| || ||  |||.||||  |  |.|. . .       . |||.   |.  |  ..||  ..|    | . .| .  .       |.. .. ||
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWPDHGVPTsVCNLLAFVRD----STRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKT--VDILGFVSTLRRHRNLMVQTEQQYIFIH
|| ..  |  |. .. ||      | . .     |..|||| | | || |. .|. ..   | ||  ||..     ||. |  .. . |.| ||.
swkekttpn.valfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 86-291 1.2e-20 68.6 In-house 34-236 (255) alignment 
Range on Protein: 86-291
Range on HMM: 34-236/255.0
DNAYIAaqgplaeTCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSR--GSLSYEDITVTLDSvtELTPYIVRTLSVQREGC--DDVRQVKQFHFT
 | |.        |   |....  ... ...||....|  ..|| .|.|    . | ..|..||       .  ..||| .  .       ..|| ....
knlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysyk

SWPDHGVPTSVCNLL---AFVRDStRadppgagPMVVHCSAGVGRTGTFIVIDVMLQ----QIHEEKTVDI--LGFVSTLRRHRNLMVQTEQQYIFIHDA
 |...  |    ..|     |||| .       ..|||||.|.||. .|...... |    .... .||..  | ..  || .|.  ..|  |  |    
GWieknaPelareilnilkvvrds.k.......svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilm

LLDAI-ISGETETSASDLRS
.|| .   || |   ...| 
vldlvfpkgeleakyqeirk
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 87-270 4.1e-25 83.1 In-house 4-196 (198) alignment 
Range on Protein: 87-270
Range on HMM: 4-196/198.0
NAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSR--GSLSYEDITVTLDSVTELTPYIVRTLSVQRE--GCDDVRQVKQFHFTS
  |||.| || ||  |||.||||  |  |.|. . .       . |||.   |.  |  ..||  ..|    | . .| .  .       |.. .. |||
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPTsVCNLLAFVRD----STRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKT--VDILGFVSTLRRHRNLMVQTEQQYIFIH
| ..  |  |. .. ||      | . .     |..|||| | | || |. .|. ..   | ||  ||..     ||. |  .. . |.| ||.
wkekttpn.valfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 94-270 2.5e-22 73.7 In-house 98-281 (302) alignment 
Range on Protein: 94-270
Range on HMM: 98-281/302.0
GPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSR--GSLSYE-------DITVTLDSVTELTPYIVRTLSVQREGCD--DVRQVKQFHFTS
 |  .|.  .| .. . |   .. |....|    |||.|.  .  | | .        ..   |.  |.   . . |. .. |       . |. ..|..
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDHGVPTSVCNLLAFVRDSTRADppgaGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIH
||||| |    . |  ..            ..||||||||||||.. |   .|   ..|. |.|  |  .|. |   ||.||| |.. 
wpdhGapkeaytaldilkfcesyk....knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyll
0048076 (Phosphotyrosine protein) phosphatases II 132-273 2.1e-27 90.9 In-house 2-139 (145) alignment 
Range on Protein: 132-273
Range on HMM: 2-139/145.0
YWPSR--GSLSYEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADPPGaGPMVVHCSAGVGRTGTFIV
||||.  ..| . .....||  .     | . |.. .|  . .|.. |.....|||||||..   ||.|..   .| . | ||..||||||||||||...
ywpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlva

IDVMLQqiheeKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDAL
...||.     . |..   .  .|..|  .|....|..|.....
aylmll.....lgvsleealelvrsqrpgavpnpgqlrflyefe
PTEN_1 148-229 1.9e-07 26.1 In-house 60-149 (196) alignment 
Range on Protein: 148-229
Range on HMM: 60-149/196.0
LDSVTELTPYIVRTLSVQREG----CDDV----RQVKQFHFtSWPDHGVPTSVCNL--LAFVRDSTRADPPgAGPMVVHCSAGVGRTGTFIV
||.  |   . | .||  .|     .|.     ..|.. || ...|||.|.  . .  .. . .. ..||.  .  .||| ||.||.|| . 
ldnlkedgitlvvnlseeeelsgrsydleeffksgveylhf.pieDhgapslselfdicksfiewllsdpn.gnvVlVHCkaGlgRsGtvva
0048179 (Phosphotyrosine protein) phosphatases II 150-271 1.8e-26 88.0 In-house 24-139 (144) alignment 
Range on Protein: 150-271
Range on HMM: 24-139/144.0
SVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADPPGaGPMVVHCSAGVGRTGTFIVIDVMLqqiheEKTVDILGFV
   .|  . | .|. ..|  .  |.. |.....|||||||..   ||.|..   .| ..| ||..||||||||||||......|.     .. ...   .
llkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk.....klglsleeal

STLRRHRNLMVQTEQQYIFIHD
  .|..|  .|....|..|...
alvrsrrpgavpnpgqlrfLle
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 161-259 1.2e-08 28.9 In-house 215-320 (347) alignment 
Range on Protein: 161-259
Range on HMM: 215-320/347.0
TLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADPPG-------AGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLR
|. |  ||| .    | .  |.|| .  |  . ..||.||   .   .          |.|| |  |. |. | ..  ....|. . || |   .   .|
tvevvaegcseatfakvyncttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiiieqvldgktpdcddlfkkmr

RHRNLM
  |  .
dqragv
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 169-274 2.8e-15 50.9 In-house 212-341 (350) alignment 
Range on Protein: 169-274
Range on HMM: 212-341/350.0
CDDVRqVKQFHFTSWPDH---GVPTSVCNLLA---FVRDS----TRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQ------QIHE--------EKTVD
.|    | |...  |.|      | |. . |     . |.    .  |   . |..||||||||||||.. .| .|.      .. .         || |
sdPyv.vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrD

I-LGFVSTLRRHRNLMVQTEQQYIFIHDALL
.    |  ||. |  |||. .|.|||..|||
lisiivnelrkqrismvqnldqfifiYeall
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 172-317 2.7e-30 100.1 In-house 88-234 (440) alignment 
Range on Protein: 172-317
Range on HMM: 88-234/440.0
VRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRA-DPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIH
 | .||.|. .|||.|||  .  .| ...|   . .  | ||..||||||.||||  |..| .|.. .    .||. |....|  |  |||| .|| |.|
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

DALLDAIISGETETSASDLRSHIRRLQEQDPESGYTPMFTEFQKLSR
.|.|.....|.|     |.  .. ..|  .| .  .|.  ||.  |.
eavlegllcgdtliledditerveqiqwpnphtdksplqqefegysk
PTPc_DSPc_SM00012 174-274 3e-36 119.2 In-house 1-104 (105) alignment 
Range on Protein: 174-274
Range on HMM: 1-104/105.0
QVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADP---PgAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEE-KTVDILGFVSTLRRHRNLMVQTEQQYIFI
.||..|.|.|||||||... ..| ..|.  .        ..|.||||||||||||||...|..|||...| |.|||. .|. ||..|. |||||.||.|.
tvkhyhytgwpdhgvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfl

HDALL
..|||
yrall
subfamily_PTPDC1_pd Subfamily PTPDC1 177-271 1.2e-07 26.3 In-house 84-170 (182) alignment 
Range on Protein: 177-271
Range on HMM: 84-170/182.0
QFHFTSWPDHGVPtSVCNLLAFVRDSTRADPPGagPMVVHCSAGVGRTGTFIVIDVMLQQ-IHEEKTvdilgfVSTLRRHRNLMVQTEQQYIFIHD
 ..  .|.|.||. |. ..|  |.  . |   |   . ||| || ||||  |   .. .. .  ||.      ....| .|   .|| .|  ....
yvynfgwkDygva.sleriLdivkvvafalqeg..kvavhChaGlGrtGvliacylvyakrltaeka......iklvrskrpksiqtreqvelvke
0038934 (Phosphotyrosine protein) phosphatases II 178-271 5.8e-09 31.4 In-house 82-174 (194) alignment 
Range on Protein: 178-271
Range on HMM: 82-174/194.0
FHFTSWPDHGVPT---SVCNLLAFVRDSTRADPPGagPMVVHCSAGVGRTGTFIVIDVMLQqiHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHD
..   .||.|..     ... | .| . ...||.|    .||| ||.|||||...   .    .  .  . .....  |..    ..  ...   ..
ylklpfpddgtvPsleillrfldlvdeflnedpgg..vvaVHCkaGlgRtGtlvaaYLiyr..lgmsaeeAialfrekRpgaipnqdyleallkryk
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 201-276 5.4e-16 53.3 In-house 219-294 (297) alignment 
Range on Protein: 201-276
Range on HMM: 219-294/297.0
DSTRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDA
.| ||. |   ...|||||||||.|  .  ||.|...  ..  |.  ..| ||  |  .||| .|. ...|| |  
eslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkk
subfamily_eak_pd Subfamily eak 206-279 1.5e-09 31.7 In-house 233-307 (332) alignment 
Range on Protein: 206-279
Range on HMM: 233-307/332.0
DPPGAGPmVVHCSAGVGRTGTFIVIDVMLQQIHEEKT--VDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIIS
 ||   | .. .. |  |.|.|.|||.... | . |.    .  ..   . .|.  | ...|. ||....|| .  
tppsfap.iiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllr
subfamily_CG42327_pd Subfamily CG42327 210-272 1.1e-17 58.7 In-house 247-310 (319) alignment 
Range on Protein: 210-272
Range on HMM: 247-310/319.0
AGPMVVHCSAGVGRTGTFIVIDVMLQQIHEE-KTVDILGFVSTLRRHRNLMVQTEQQYIFIHDA
 ||.||||| ||||||. |  |. .... |  ..|||   || .|| |   |.| .|| ||.  
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
subfamily_CDC14_pd Subfamily CDC14 210-268 3.3e-06 21.2 In-house 263-317 (328) alignment 
Range on Protein: 210-268
Range on HMM: 263-317/328.0
AGPMVVHCSAGVGRTGTFIVIDVMLQqiHEEKTVDILGFVSTLRrhrNLMVQT-EQQYIF
 | ..||| ||.|||||.|   .| .  ..  . ......   |     .| .  |... 
eGaiavhCkaGLGrtGtLiacylmkh..yrftaaeaiawlricr...PGsvigpqqkfle
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 211-275 4.2e-10 33.5 In-house 266-342 (349) alignment 
Range on Protein: 211-275
Range on HMM: 266-342/349.0
GPMVVHCSAGVGRTGTFIVIDVMLQ-----QIH------EEKTVDIL-GFVSTLRRHRNLMVQTEQQYIFIHDALLD
 ...|||||| ||||... .|..|.     | .      . .. |..   | .||. |  |||  .|.|.|..||| 
stllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 213-278 1.1e-22 74.2 In-house 1-66 (69) alignment 
Range on Protein: 213-278
Range on HMM: 1-66/69.0
MVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAII
||||||.| ||||||| | | . .|  || |||.  |  .|. | .||  |..|||||||| .|. 
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealk
subfamily_PTEN_pd Subfamily PTEN 213-267 5.3e-06 21.5 In-house 117-170 (184) alignment 
Range on Protein: 213-267
Range on HMM: 117-170/184.0
MVVHCSAGVGRTGTFIVIDVMlQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYI
.|||| || ||||. ||  .. .. . ||. ..| . .. | . .  |.   |  
vvvHCkaGkGRtGvlivayll.kslllekaeealelfaeaRtknkkgvtiPsqrR
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 214-279 1.9e-21 70.2 In-house 1-66 (69) alignment 
Range on Protein: 214-279
Range on HMM: 1-66/69.0
VVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIIS
|||||.| ||||||| | | . .|  || |||.  |  .|. | .||  | .|.|||||| .|.  
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealkl
0051299 (Phosphotyrosine protein) phosphatases II 280-570 2.8e-97 320.9 In-house 1-286 (288) alignment 
Range on Protein: 280-570
Range on HMM: 1-286/288.0
GETETSASDLRSHIRRLQeqdpESGYTPMFTEFQKLSRCINSsLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFI
|.|| |...|......|.     .|.| .. ||..| ... . |.|.|| .| |. |||| ..|||| .||.||.  ||||||||||.|||||  ||.||
gdteisveellklvlkll....angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfI

ATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQPITFGSLVVEMQDKVKSGHLVVRIFKLTNT----EVSASRDVRQFHYTSWTEE
|||.| |.|. ||||||||||. .||.| ..||  . |...||| ....|.| ..|.. . .. .. .|| ...||.      . || |..||||.| . 
atqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdh

NPLEdglSRCQLIDLIGQVQYWQAeSGRHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
.  .   |  .|.|.. .|. ..| || .|..|||||||||||.|.|. .|.|.|..| .|||...||.|||||| ||||  || |.|...||||
gvpd...spellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 280-574 2.5e-95 314.2 In-house 1-294 (298) alignment 
Range on Protein: 280-574
Range on HMM: 1-294/298.0
GETETSASDLRSHIRRLQEQDPESGYTPMFTEFQKLSRCIN--SSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRT
|.|| .|.||. ....|.. ... . | . .|||.|..  .   . . ..| .| ||.|||||.....| .||.|. . . | |||||| ....|  . .
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

FIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENP
|||||||..||. ||||||.|..  ||| | . .|. | |.|.||| ..  |.|.. |... | . . |.|| .|....... .| |||.|.|||...  
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgv

LEdglSRCQLIDLIGQVQYWQAESGRHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLASFE
 |     . ..||. .|. .| ..| .|.||.|||||||.| |.|.. ..||.|.| .|||||.|| ||..||..|||. || |.|..|||.|.||.
pe...natsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfn
subfamily_PTPRB_pd Subfamily PTPRB 285-571 1.4e-85 281.9 In-house 8-286 (293) alignment 
Range on Protein: 285-571
Range on HMM: 8-286/293.0
SASDLRSHIRRLQeQDPESGYTpmfTEFQKLSRcINSSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAP
..... .|..... .| . ...    |...|.  .... . .||...||. |||| |.|||| .||.|.   . .||||||||||.|| ..| ||||| |
klekfeehvkkmk.adsdlrfs...eeyeelka.vgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGP

IPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGK-QPITFGSLVVEMQDKVKSGHLVVRIFKLTNteVSASRDVRQFHYTSWTEENPLEDgls
.|||. ||||||||... .|| | | ||. | | ..||| . .|...|.. |... . .  . |.| .|...   ...|.|||.|.|||.. .  |.   
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPek...

RCQLIDLIGQVQYWQ-AESGRHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLA
  .|.|.. .|. ..  .. ..||.|||||||||||.| |.  |..... | .||.| .| .|||.|  .|||. || | .|.||..| 
tktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_PTPN6_pd Subfamily PTPN6 285-571 5.9e-71 234.0 In-house 5-298 (306) alignment 
Range on Protein: 285-571
Range on HMM: 5-298/306.0
SASDLRSHIRRLQEQDPESGYTPMFTEFQKLSRC-INSSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSmQVGVEGSDYINANYIDGYMA--KRTFIAT
 |.........|.... . . . .  ||..|..   .. || . ...| ||.|||| |.||.| ||| |. . .| ||||||||||.. .   ....|||
lakeieqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiat

QAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQ-PITFGSLVVEMQDKVKSGHLVVRIFKLT-NTEVSASRDVRQFHYTSWTEENPLE
|  ...|..|||||||..|.  || . .|||..| |  |||| ..   ..|.. |.. .. .  . ..| .... ... . .|.|.|.|..|| ...  .
qgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpk

DGLSRCQLIDLIGQVQYWQAESGRHPIIVHCSAGVGRTGVFCAVSILIERLK---AEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLA
|     .... . . |   .|.   ||.||||||.|||| |  . ||.. ..    .| .|. ..||..||||  .|||. || | |... .|. 
dpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 289-571 4.6e-78 257.2 In-house 2-277 (281) alignment 
Range on Protein: 289-571
Range on HMM: 2-277/281.0
LRSHIRRLQEQDpESGYTpmfTEFQKLSRcINSSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPET
|| |...|...| ..|..   .|..||.  |. . . .|.... |. |||| |.  || |||... .   . .||||||...||  .. .||||.|.|..
lrkhlkqlsqnd.naGfi...eeyeklaa.igvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPas

IPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQ-PITFGSLVVEMQDKVKSGHLVVRIFKLtNTEVSASRDVRQFHYTSWTEENPLEdglSRCQL
. .||.|||||. ..|| ...|.|. | | ||||| ..  ...| ..|... . .. . . | ||| ..| . .|.|.|..||.| .    .   .  .|
lvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPa...ttkel

IDLIGQVQYWQAESGRHPIIVHCSAGVGRTGVFCAVSILIERLKAE-AMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLA
..   .|.  . ..  .|...||||||||||.. |.  |.....|| ...|| ..|..||..|  ||||  ||.| |..||..| 
lefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 289-570 1.2e-59 197.0 In-house 7-279 (439) alignment 
Range on Protein: 289-570
Range on HMM: 7-279/439.0
LRSHIRRLQEQDPESgYTPMFTEFQKLSRCINSSLSLNAatHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPET
.. |. .|. .. |  .. .| . .  |   .   || |  .  .. |||| .| ..| ||| |    ||  | |||||||.||  .. .||||.|  ||
fqehvekldknkqei.fkeifekinstspdyaciaslaa..qeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkket

IPDFWRMVWEQNCCTIVTLAQEVEQAKakmhrYWPGKQPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVS--ASRDVRQFHYTSWTEENPLEDglsRCQ
  ||||.|.|... |||.|.. ||  |     ||| .. . .| ..| .. ...  . |.| ||. |   .    | | ||||..| ..|   .      
tddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaq...ash

LIDLIGQVQYWQAESGRHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
..|..  ..  . .    |..|||||||||||   |. | .|.||.|  ||.   || ||.||  |||.  || | |. ||| .
vldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
0039614 (Phosphotyrosine protein) phosphatases II 291-571 6.8e-87 286.9 In-house 17-290 (297) alignment 
Range on Protein: 291-571
Range on HMM: 17-290/297.0
SHIRRLQEQDPESGYTPMFTEFQKLSRCINSslsLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGV-EGSDYINANYIDGYMA-KRTFIATQAPIPET
|.. .|.  .. .. | ...||..| ... .      | .|.|| |||| ..|||| .||.|..  || ..||||||.|.|||   .|.|||||.| |||
svldlllllekansktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpet

IPDFWRMVWEQNCCTIVTLAQEVEQAKaKMHRYWPGKQPiTFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSasRDVRQFHYTSWTEENPLEDGLSRCQLI
. |||||||||.. .||.| ..||  . | ..||| ..  |.| ..|.. .  . .. .|| ...||.. |  | |..|.||.| . .. ..  . ....
vedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtnnges..rtvthfqytgwpdhgvppslelllefl

DLIGQVQYWQaeSGRHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLA
.|. ... .   .. .|..|||||||||||.|.|  ...|.|. |  |||...||.|||||| .||| .|| |.|...||.| 
elvrealael..pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk
0045450 (Phosphotyrosine protein) phosphatases II 294-570 1.7e-87 289.3 In-house 15-304 (307) alignment 
Range on Protein: 294-570
Range on HMM: 15-304/307.0
RRLQEQDPESGYTPMFTEFQKLSRCINS-SLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGV-EGSDYINANYI--------DGYMAKRTFIATQA
  |. ... .. | .. ||.|| ..    . . ..| .|.|| |||| ..|||| |||.||   |  |.||||||.|.        |||  ||.|||||.
lllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqg

PIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGK-QPITFGSLVVEMQDKVKSGHLVVRIFKLTNT-EVSASRDVRQFHYTSWTEENPLEdg
| |||. |||||.|||.. .||.| ..|| .. | ..||| . ...|.| ..|.. .. . ....|| ...|.. . . || |..||||.| . .  .  
PlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpp..

lSRCQLIDLIGQVQYWQAES-GRHPIIVHCSAGVGRTGVFCAVSILIERLKAEAM---VDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
 |  .|.|.| .|. ...|. . .|..|||||||||||.|.|  .....|..| .   ||....||.|||||| .||. .|| |.|...||.|
.sfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 294-574 1.9e-68 225.5 In-house 8-282 (287) alignment 
Range on Protein: 294-574
Range on HMM: 8-282/287.0
RRLQEQDPESGYTPMFTEFQKLSRCINSSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSmqvgVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFW
 .. ..... | .   . |. | .  ..  ..  .  . || |||....|..|  || |      |  ||||| .||||  |. ||....|. .|. .||
gefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfW

RMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQPITFGSLVVEMQDKVKSGHLVVRIFKLTNTE-VSASRDVRQFHYTSWTEENPLEDGLSRcqlIDLIG
......|  .|| |.|| |. . . ..||| .. ...|   .|. .. .. . ..| ....|..  .. . |.|...|.| ..  ...  .    . .| 
kliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqti...llvie

QVQYWQAESGRHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLASFE
.    |  .|. .|.||||..|||...|||. . |.. | |  .|||| .|. | |.| .|||  || | ...||||| |||
emyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfe
0050432 (Phosphotyrosine protein) phosphatases II 296-572 9.2e-95 312.8 In-house 32-301 (308) alignment 
Range on Protein: 296-572
Range on HMM: 32-301/308.0
LQEQDPESGYTPMFTEFQKLSRCINsSLSLNAATHPVNKRKNRYANVLPYDVTRVRLsmqvGvEGSDYINANYIDGY--MAKRTFIATQAPIPETIPDFW
|.  ..  ... ...||..| .. . .|. ..| .| || |||| ..|||| .||.|    . ||||||||.|.|||    .|.|||||.| |.|. |||
lkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFw

RMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGK---QPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEDglsRCQLIDL
|||||||. .||.| ..||  . |...||| .   .....| ..|.. .  . .. .|| ..|||.. . || |..||||.| . .  ..     .|.|.
rmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPps...peilldf

IGQVQYWQaesGRHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLAS
. .|. ..   . .||.|||||||||||.|.|. .|.|.|..| .||||..||.|||||| ||||. || |.|...|||| .
lelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
0047943 (Phosphotyrosine protein) phosphatases II 299-570 1.7e-90 298.5 In-house 5-272 (273) alignment 
Range on Protein: 299-570
Range on HMM: 5-272/273.0
QDPESGYTPMFTEFQKLSRCINsSLSLNAATHPVNKRKNRYANVLPYDVTRVRLsmqvGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWE
 .. .|.| .. ||..| .... .|. ..| .| || |||| ..|||| .||.|    | .|||||||.|.|||  ||.|||||.| |.|. ||||||||
lekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvwe

QNCCTIVTLAQEVEQAKAKMHRYWPGKQ---PITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEdglSRCQLIDLIGQVQ
||. .||.| ..||  . | ..||| ..   ..|.| . |.. .  . .. .|| ..|||.. . || |..||||.| . .  .   |  .|...| .|.
qnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvpp...slesllefielvr

YWQAES-GRHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
 ..... . .|..|||||||||||.|.|. .|...|..| .|||...||.||.||| ||||  || |.|...||||
kalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 299-568 6.2e-78 257.3 In-house 27-289 (319) alignment 
Range on Protein: 299-568
Range on HMM: 27-289/319.0
QDPESGYTPMFTEFQKLSRCINSSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWE
.| .   | .  ||.....   .    . |  . || |||. |.|..| ..|.|   .|.|.|||||| ...||  |  .||.| | ..|. |||||.||
sdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiwe

QNCCTIVTLAqeveqaKAKMHRYWPGKQPITFGSLVVEMQDKVKSGHLVVRIFKLTN-TEVSASRDVRQFHYTSWTEENPLEDGLsrcQLIDLIGQVQY-
.||.||| |.      | |  .||| |  |. .   |...   ..   ||| ..|.. ..    |...|||.  | .    . .    .|. |. .|.. 
yncstivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdyps...dlmrlvkkvrhl

WQAESGRHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLE
 . | .|..|.||||||||||||. .. .|..|.| | .|||...|..||.||. .||   || |.|  .||
tskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_PTPN12_pd Subfamily PTPN12 299-570 2.1e-77 254.9 In-house 4-277 (290) alignment 
Range on Protein: 299-570
Range on HMM: 4-277/290.0
QDPESGYTPMFTEFQKLSRCINSS--LSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMV
.. |  ..  |....|||.   ..   | .|.....|..|||| ..|||| .|| || . ..|||||||||.| |   | ..||.|.|.|.|. |||||.
kegeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmi

WEQNCCTIVTLAQEVEQAKAKMHRYWPGK--QPITFGSLVVEMQ-DKVKSGHLVVRIFKLTNTevSASRDVRQFHYTSWTEENPLEdglSRCQLIDLIGQ
||.|   .| . .||| .| | .|||| .  ....||.. |... .|  .  ...| .|...   ..|| |.|||||.| . .  .   |  .|..|| .
weknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPs...sakslleliel

VQYWQAeSGRHPIIVHCSAGVGRTGVFCAVSILIERLKAEAM---VDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
|.  |  |  .|..|||||||||||. .|. .  | |||| .   .|||. | .||.||.|.|||| || . |. |.|..
vrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
0036941 (Phosphotyrosine protein) phosphatases II 301-572 7.5e-89 293.2 In-house 8-279 (297) alignment 
Range on Protein: 301-572
Range on HMM: 8-279/297.0
PESGYTPMFTEFQKLSRCINsSLSLNAATHPVNKRKNRYANVLPYDVTRVRLsmqvGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQN
. .... . .||..| .... . ||..|  | |. |||| ..|||| |||.|    . ||||||||.|.|||  ||.|||||.| |.|. ||||||||||
kllflalllkefeellplll.lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqn

CCTIVTLAQEVEQAKAKMHRYWPGK--QPITFGSLVVEMQDKVK--SGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEdglSRCQLIDLIGQVQY
. .||.| ..||  . | ..||| .  ...|.| ..|....  .  ... ..| ...|.|. . || |..||||.| . .. |   |  .|.|.| .|. 
vtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpe...spaslldfielvrk

WQAES-GRHPIIVHCSAGVGRTGVFCAVSILIERLK---AEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLAS
..... . .|..|||||||||.|.|.|. .....|.    |  ||....||.|||||| .||| .|| |.|...||.| .
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk
subfamily_PTPRG_pd Subfamily PTPRG 302-572 8.7e-77 253.6 In-house 18-289 (563) alignment 
Range on Protein: 302-572
Range on HMM: 18-289/563.0
ESGYTpmfTEFQKL-SRCINSSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGS-DYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQ
. |..    ||..| |..|...|  ... .| ||||||| |...|| .||.||   |.... |||||||||||  .. ||||| |...|. |||||.|||
digfs...eefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeq

NCCTIVTLAQEVEQAKAKMHRYWPGKQPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVS------ASRDVRQFHYTSWTEENPLEDGLsrCQLIDLIGQ
|  .||.... ||. . | ..|||  ...|.|.| | .... .     || ... |...         . |||.|||.| . .  |  |   .||  . .
nvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehsl..pvLifvkks

VQYWQAESGrhPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLAS
 .  .|| |  ||.|||||||||||...... |......| .|.||...|..| ||. .|||. || | ....|| .||
saankaeaG..PivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
0043336 (Phosphotyrosine protein) phosphatases II 303-570 2.6e-87 288.1 In-house 17-277 (278) alignment 
Range on Protein: 303-570
Range on HMM: 17-277/278.0
SGYTPMFTEFQKLSRCINssLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCC
...| .  ||..| ..     . . | .| || |||| ..|||| .||.||.  |...||||||.|.|||  .|.|||||.| |||. ||||||||... 
nlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvt

TIVTLAQEVEQAKAKMHRYWPgKQPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEdglSRCQLIDLIGQVQYWQAeSG
|||.| ..||  . | ..||| ....|.| ..|....  . .. .|| ...||.  . || |...||..| . .  |   |  .|.|.. .|. ... . 
tivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpe...slsllldflkavreale.ds

RHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
 .|..|||||||||||.|.|. .|.|.|. |  ||....||.|||||| .|||  || |.|...||||
ngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 303-570 1.4e-38 127.6 In-house 13-277 (307) alignment 
Range on Protein: 303-570
Range on HMM: 13-277/307.0
SGYTPMFTEFQKLSRCINSSLSLNAAThpVNKRKNRYANVLPYDVTRVRLSMQvGvEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCC
 | . .  ||..|..    ... .| .   |  |||| .|   | .|. . .. |   |||| |||.   .  . ||..| |  .|. .|| |. ...  
kgvqalvdefrvlakktpegvtveafs..antdknryqdvkcqdkgrivvkfd.g.lasdyihanylgiaikpkkficaqgplentqysfwamaiqekve

TIVTLAQEVEQAKAKMHRYWPGKQ--PITFGSLVVEMQ-DKVKSGHL--VVRIFKLTNTEVSASRDVRQFHYTSWTeeNPLEDGLSRC--QLIDLIGQVQ
... |.. .| || | ..||| ..    .||.    .  ... ...|     . ..|. .|  ... |  ..  |.  |  . |  .     |.|.  |.
svimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwe..nwpdrgvpqinltainlleavr

YWQaesgrHPIIVHCSAGVGRTGVFCAVSILIERL-KAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
| .      |..|||||||||.|   |.|.. ... . .   |. . |..||.||.  .||. || . ..|.|||.
ydt.....npvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 303-570 4.1e-31 102.9 In-house 19-287 (305) alignment 
Range on Protein: 303-570
Range on HMM: 19-287/305.0
SGYTPMFTEFQKLSRcINSSLSLNAATHPVNKRKNRYANVLPYDVTRVRLsmqVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCC
 | . . .||. . | .|    ..|  .  .. |||| .|   |  ||.|    |    .|| |||.      . || ||||. .|  ||| | ....  
kgpaglraefvamkr.fndfekmkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkve

TIVTLAQEVEQAKAKMHRYWPGKQP--ITFGSLVVEMQDKVKSGH----LVVRIFKLTNTEV------SASRDVRQFHYTSWTEENPLEDGlsrCQLIDL
.|  | . .|.   | . |.. |.   ..|      .. |..| .          |.|.|..      . .| | ..|.  | .            ...|
aifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaad...lailel

IGqvqywQAESGRHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVF-QTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
.      .| . . ||.||||||.||||    .  ....| |  ...   . ....||||   .||  || | .||.|.|.
le.....karpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 304-574 7.6e-140 460.5 In-house 18-284 (318) alignment 
Range on Protein: 304-574
Range on HMM: 18-284/318.0
GYTPMFTEFQKLSRCINSSLSLNAaTHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCT
|.. ...|...|||. ... ||.. ..||||.||||||.|.|| |||.|.|..|.||||||||||||||..|...||.|||.||||.||||||||||...
Gelllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsav

IVTLAQEVEQAKAKMHRYWPGKQPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEDGlsrCQLIDLIGQVQYWQAESGR
||.|.||.|..|||.|||||.|.....|.||||....|.....|.| ||.|.||...||.|||.|||||..|. .|.|   ..|.||..||...|..||.
ivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesg...aslldlvrqvskaqqksga

HPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLASFE
.||.|||||||||||||.||.||.||.||||.||||||||||||||..||||. ||.|.|.|.||.|||..
gpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgd
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 304-568 2.6e-81 267.8 In-house 19-277 (288) alignment 
Range on Protein: 304-568
Range on HMM: 19-277/288.0
GYTPMFTEFQKLsRCINSSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCT
. | .  |...|   .... | .|. ..||..|||| |.|||| .||.|     ..|.|||||.||||.  |...||||.|...|. |||..|.|..  |
nrtgfseeynsL.aalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktst

IVTLAQEVEQAKAKMHRYWPGKQ-PITFGSLVVEMQDKVKSGHLVVRIFKLTntEVSASRDVRQFHYTSWTEENpLEDglSRCQLIDLIGQVQYWQAESg
|| |.. ||. | | ..||| .. |  .||. |..... . .. |.| . |        ... |..|..|....   .  |  .|..|. ||.  . .  
ivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhg.vPe..skapllellrqvkvanqad.

RHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLE
  ||||||||||||||.| |.  ||.....| ..||. ||..||.||. .|||. || |.|.|.|.
tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_PTPN23_pd Subfamily PTPN23 305-569 2.7e-64 211.7 In-house 17-279 (288) alignment 
Range on Protein: 305-569
Range on HMM: 17-279/288.0
YTPMFTEFQKLSRCINSSLSLNAAThpVNKRKNRYANVLPYDVTRVRLSmqvgVEGSDYINANYIDGYMAK-RTFIATQAPIPETIPDFWRMVWEQNCCT
    | |...     . . |. .|   ..  |||. ..|||| .|| |      .  ||||| .. .  .   .|||||||...|. |||.||.||   .
ldkkfkeleqkqdkearkrsiaiak..lyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssv

IVTLAQEVEQAKAKMHRYWPGK--QPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEE-NPLedglSRCQLIDLIGQVQY---W
|| | .. |. | |..|||| .  .. .|| | | .... .... | |..||.  ...| ..|.  ..|||.|   |     |  .|......|.     
iVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPa....sPetllqfldevesayea

QAESGRHPIIVHCSAGVGRTGVFCAVSILIERLK-AEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEY
. .  . |..|||||||||||||. |   .. |.  . ..|. | |..|||||  |||.| |. |.|..|||.
vqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_PTPN1_pd Subfamily PTPN1 305-568 6.7e-55 180.8 In-house 8-269 (290) alignment 
Range on Protein: 305-568
Range on HMM: 8-269/290.0
YTPMFTEFQKLSRcinsSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGvegsDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTI
|...... .| ..     .. ..| .| |. .||| .| ||| .|..|  .      |||||. ..   ||| .| || |.|.|.  ||.|||||.. ..
ykeiyldirkeas....dfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskav

VTLAQEVEQAKAKMHRYWPGKQP---ITFG--SLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEDGLSRCQLIDLIGQVQYWQA
| | . ||. . | ..||| ..    ...   .| |..  . .. . .||...|.| .   .|.. .||||.|..    |   .  ...  . .    . 
vmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslss

ESGrhPIIVHCSAGVGRTGVFCAVS---ILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLE
. |  | ..|||||.||.| || |    .|||. .  . ||. ... .||..|  ..||. | .| |. .||
dvG..pavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_PTPN14_pd Subfamily PTPN14 306-571 5.5e-61 201.2 In-house 23-297 (300) alignment 
Range on Protein: 306-571
Range on HMM: 23-297/300.0
TPMFTEFQKLSRCINsSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVeGSDYINANYIDGYMA--KRTFIATQAPIPETIPDFWRMVWEQNCCT
. .|||......  .    |..|. |.|..|||. .||||. .||.|| .     ..||||  |   ..  .|..|..|.|.. |. |||.|||||.   
gkvfteyeripkkre.dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvql

IVTLAQEVEQAKAKMHRYWPGK----QPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEDGLSRCQLIDLIGQVQYWQA
|| |..| |. | | ..|.| .    . ..||   |  . . .|. .. . .||     .  |.|  . || |....  ||  .  . .. .  |..   
ivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktn

ESG-----RHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLA
..      . |..||||||||||||   . .||. |. .  .|. .....|||||  .||| .|| | |.|...|| 
seveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
0049772 (Phosphotyrosine protein) phosphatases II 306-571 1.8e-48 161.2 In-house 19-281 (314) alignment 
Range on Protein: 306-571
Range on HMM: 19-281/314.0
TPMFTEFQKLSRCINSSLSLNAATHPVNKRKNRYANVLPYDvTRVRLsMQVGVEGSDYINANYIDGYmakRTFIATQAPIPETIPDF----------WRM
. .. ..  .|  . ..|.. .| ...|. |||| ..||.| .||.|   ..|.|||||||.|.||.   ..|||||.| ..|. ||          |||
lklllvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrm

V--WEQNCCTIVT---------------------LAQEVEQAkakmhrywPGKQPITFGSLVvemqdkvksghlvvrifKLTNTEVSASRDVRQFHYTSW
|  ...|. .||                      | .  ..         .   . ..  |                  . ..     .| . ..... .
vlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng........neptaadlellk.................eelydpelferlgikylripv

TEENPLedglSRCQLIDLIGQVQYWqaeSGRHPIIVHCSAGVGRTGVFCAVSILIERLKaeamVDVFQTVKQLREQRP-----AMVQTKGQYDFCYQVVL
. ...     .  .. ...  .. .   .  .|..|||.||.||||.|... .|. .|.    |.. ......|..||      ....  || |.....|
pDgsap....lledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefileall

EYLA
||| 
eylk
0040438 (Phosphotyrosine protein) phosphatases II 307-570 5.8e-90 297.1 In-house 19-276 (317) alignment 
Range on Protein: 307-570
Range on HMM: 19-276/317.0
PMFTEFQKLSRCINSslSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVT
 .  ||..| ... .  . . | .|.|| |||| ..|||| .||.||   |...||||||.|.||.  ||.|||||.| |.|. |||||||||....||.
alleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivm

LAQEVEQAKAKMHRYWPGKQPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEdglSRCQLIDLIGQVQYWQAeSGRHPI
| ...|  . | ..||| ....|.| ..|.... .. .. ..| ....... | || |..||||.|.. .. .   |  .|.|.. .|. ... .. .|.
LteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvpp...spdllldfleavreale.dpggpv

IVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
.|||||||||||.|.|. ...|.|. |  |||...||.|||||| .||| .|| |.|...||||
lVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
0046845 (Phosphotyrosine protein) phosphatases II 308-572 1.2e-90 299.0 In-house 2-276 (284) alignment 
Range on Protein: 308-572
Range on HMM: 2-276/284.0
MFTEFQKLSRCINSSL-SLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGV-EGSDYINANYIDGY-----MAKRTFIATQAPIPETIPDFWRMVWEQN
.. ||..| ..  . | ||..| .| |. |||| ..|||| .||.|..  |  |.||||||.|.|||     . |..|||||.| |.|. ||||||||||
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

CCTIVTLAQEVEQAKAKMHRYWPGKQ-PITFGSLVVEMQDKVKSGHLVVRIFKLTNTE-VSASRDVRQFHYTSWTEENPLEDglsRCQLIDLIGQVQYWQ
. .||.| ..||  . |...||| .. ..|.| . |.. .. . .. .|| ..|||..  . || |..|||||| . .  ..     .|.... .|. ..
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvpps...pedlleflrlvrell

AE-SGRHPIIVHCSAGVGRTGVFCAVSILIERLKAEA---MVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLAS
 . .| .||.|||||||||||.|.|. .|.|.|..|    .|||...||.|||||| ||||  || |.|...|||| .
enlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
subfamily_Ptp69D_pd Subfamily Ptp69D 308-570 2.3e-79 261.7 In-house 24-286 (307) alignment 
Range on Protein: 308-570
Range on HMM: 24-286/307.0
MFTEFQKLSRCiNSSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTL
.  |..|| .  ....| ... .  |. |||| .. ..| |||.|.   | | ||||||..| ||  |..||| |.|. .|| |||||..||.  .|| |
lakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivml

AQEVEQAKAKMHRYWPGKQPITFGSLVVEMQDKVKSGHLVVRIFKLTNTE-----VSASRDVRQFHYTSWTEENPLEDGLSrcqLIDLIGQVQYWQAESg
... |. ..|...|||  . . .|...|.. .. | .. . | .......     | .|| | |.|||.| . .  |   .   |..|| ||.  .  . 
snlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevarg...llklieqvrelykln.

RHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
| ||.|||||||||.|.| |...|...||||  ||.|.|||.||.||. .||   || |.|. .|.| 
rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldys
subfamily_PTPN3_pd Subfamily PTPN3 308-568 5e-63 207.6 In-house 17-273 (280) alignment 
Range on Protein: 308-568
Range on HMM: 17-273/280.0
MFTEFQKLSRCiNSSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQvgvEGsDYINANYID----GYMAKRTFIATQAPIPETIPDFWRMVWEQNCCT
....|..| |  . .|...||  | |  |||| ..|||| |||.|. .   |  |||||||..    .  .   .|||| |...|  |||.|||||.. .
vlaqfeqlyrk.kpglaisaarkpenlsknryrdilpydatrvklkes...et.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssl

IVTLAQEVEQAKAKMHRYWPGK-QPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEDglsRCQLIDLIGQVQYWQaESG
|| |.. ||. . | |.||| . . ...|.. |... . ..   |.| . |...| . .| . |. |..|....  .|     ...... .|.  . .. 
ivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPdd...sadflefvervrklr.sgk

RHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLE
..|..||||||.|||||. .. . .  . |.  | . . |...|.|| ..|||..|| |  . .|.
eePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk
subfamily_CG42327_pd Subfamily CG42327 308-475 1.1e-25 85.0 In-house 7-174 (319) alignment 
Range on Protein: 308-475
Range on HMM: 7-174/319.0
MFTEFQKLSRCINSSLslnaATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYM-AKRTFIATQAPIPETIPDFWRMVWEQNCCTIVT
.. ||..| . | ..     .  .  | |.|..||.|   ||| |  .   . . |..|.|. ||  |.  .||.|..  ..  ||||.||||.  .||.
vaeefrdlPqliarad....evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivq

LAQEVEQAKAKMHRYWPGKQPI----TFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYtSWTEE
|..  |.   .  .|.| |.      ..| . | ....    . ..  . | . . . ||..  . |  | | 
ltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwlea
DSPc_SM00195 309-570 7.8e-87 286.3 In-house 3-262 (263) alignment 
Range on Protein: 309-570
Range on HMM: 3-262/263.0
FTEFQKLSRCINSSlSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLA
 .||.|| .  ... . . | .. ||.|||| |.|||| |||.|. . . |||||||||||.|.  |...||||.| |.|. ||||||||... .||.| 
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

QEVEQAKAKMHRYWPGK--QPITFGSLVVEMQDKVKSG-HLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEDGLSrcqLIDLIGQVQYWQAESgRHP
.|.|. | |..|||| .  .. |||.. |..... |   ....| ..||... . .|.|.|..|..|....  ..  |   ...|. .|. .. .|  .|
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstks...vlellravkksksts.sgp

IIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
|.|||||||||||.|....|....|..| .||.|..||.||.||| ||||. || |.|...|||.
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 309-570 7.8e-87 286.3 In-house 3-262 (263) alignment 
Range on Protein: 309-570
Range on HMM: 3-262/263.0
FTEFQKLSRCINSSlSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLA
 .||.|| .  ... . . | .. ||.|||| |.|||| |||.|. . . |||||||||||.|.  |...||||.| |.|. ||||||||... .||.| 
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

QEVEQAKAKMHRYWPGK--QPITFGSLVVEMQDKVKSG-HLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEDGLSrcqLIDLIGQVQYWQAESgRHP
.|.|. | |..|||| .  .. |||.. |..... |   ....| ..||... . .|.|.|..|..|....  ..  |   ...|. .|. .. .|  .|
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstks...vlellravkksksts.sgp

IIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
|.|||||||||||.|....|....|..| .||.|..||.||.||| ||||. || |.|...|||.
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 310-574 3.5e-94 310.4 In-house 27-287 (319) alignment 
Range on Protein: 310-574
Range on HMM: 27-287/319.0
TEFQKLSRCINSslSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQ
 ||..|.   |   ... |... ||.|||| |.|.|| ||| ||   ||||||||||..||||  .. |||||||. .|| ||||||||... ..| |..
kefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltk

EVEQAKAKMHRYWPGKQPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSA-SRDVRQFHYTSWTEENPLEDGLSrcqLIDLIGQVQYWQAESGRHPIIV
 ||. | |...||| ... ..| |.|..... .  ....| .|| .      .|.| .|.||.|....  |...|   |.||.....  . ..   ||.|
lveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekats...lldllkrirksrektqsgPivv

HCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLASFE
|||||||||| |..... .||.| |...|||.||..|| ||. |||.. || |.|...||.. ...
hCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
0045098 (Phosphotyrosine protein) phosphatases II 310-571 9e-80 263.3 In-house 13-273 (278) alignment 
Range on Protein: 310-571
Range on HMM: 13-273/278.0
TEFQKLSRCInssLSLNAATHPVNKRKNRYANVLPYDVTRVRlsmqvgvegsDYINANYIDGYmaKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQ
.||. |  ..    . . |  . |. |||| ..|||| .||.          |||||.|||||  ...|||||.| |.|. |||||.||... .||.|..
fefllllgip...seitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmlte

EVEQAKAKMHRYWPGKQPITFGSLVVEMQDKVKSGHLVVRIFKLTNT----EVSASRDVRQFHYTSWTEENPLEDG--LSRCQLIDLIGQVQYW------
.|| .. |...||| ....|.| ..|....    .. ..| ...||.    |   || |...||..| . .. ..    |  .|.. | ... .      
lvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslll

---QAESGRHPIIVHCSAGVGRTGVFCAVSILIERLkaEAMVDVFQTVKQLREQRPA-MVQTKGQYDFCYQVVLEYLA
   ..... .|..|||||||||||...|. ...|.|  |  ||....||.||.|||  .||...|| |.|...||.| 
sslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 310-574 4.7e-69 227.4 In-house 24-287 (290) alignment 
Range on Protein: 310-574
Range on HMM: 24-287/290.0
TEFQKLSRcINSSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEG--SDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTL
..|..|    .|. . . .. . ||..||.||...||  |. |    | .    .|||| ||.||  |. .||||.|...|. |||...|..... || |
nqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivml

AQEVEQAKAKMHRYWPGKQPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEV-SASRDVRQFHYTSWTEENPLEDGLSrcqLIDLIGQVQYWQAESGRHPI
 ...|. | | . ||| ..  ..|   .....  .  . . | ....|..   |.. | |.. |.| ..  ...  .    . .| ...  |  .|...|
tniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqt...illvieemyktqrkrgntsi

IVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLASFE
.||||..|||..||||. . |.. | |  .|||| .|..| |.| .|||. || . .|.||.|| |||
vvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfe
subfamily_PTPN13_pd Subfamily PTPN13 310-572 5.7e-66 217.6 In-house 15-271 (273) alignment 
Range on Protein: 310-572
Range on HMM: 15-271/273.0
TEFQKLSRcINSSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGvegsdYINANYIDGYMAKRTF--IATQAPIPETIPDFWRMVWEQNCCTIVTL
 ||..|   . . .. . . .  ||.|||| |||||| |||.|. . |     ||||..|   . | ..  ||.| |.|||. |||.|||||..  |. .
eefkelre.lkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv

AQEVEQAKAKMHRYWPGK--QPITFGS-LVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEdglSRCQLIDLIGQVQYWQAesGRH
..|.|. | | ||||| .  ....  . | ||. . .|   .||| ......| ..||.| ......| . .      |  .|. .. .|.  |    . 
tlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPs...saaellqfvaevrrlqt..dag

PIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLAS
||.||||||.||.|.. .. .... .. .  .|| ..|..||||| ..|||| || |.|...|| | |
PivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlks
subfamily_PTPRN_pd Subfamily PTPRN 310-568 1.1e-56 186.7 In-house 33-290 (297) alignment 
Range on Protein: 310-568
Range on HMM: 33-290/297.0
TEFQKLSRCINSSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYID-GYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLA
 |.. | .  .   . ..| .. | .|||...||||| .||.|. .   | ||||||  |      . ..||||.|...|. |||.||||| .. ||.|.
kewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnlt

QEVEQAKAKMHRYWPGKQPITFGSLVVEM-QDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEdglSRCQLIDLIGQVQywQAESGR-HPI
.  |.   ...|||| .   ...   |..  ... .   .|| | | | . | .| | |||. ||.||.      |   |...  .|.  ..  ||  ||
rleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPa...saksllefrrkvn..ksyrGrscpi

IVHCSAGVGRTGVFCAVSILIERLKA-EAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLE
.||||.|.|||||.... ....||.     .|.  |.. ||.||| .|.|| |..|....| |
vvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 310-569 2.1e-47 156.4 In-house 10-258 (267) alignment 
Range on Protein: 310-569
Range on HMM: 10-258/267.0
TEFQKLSRCINSSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQvgveGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQ
 ||... .  . |  .       |. .||. ..|||| ||| |. .      .|||| |..||  |..||.|| |.  || ||. .. .|.. .|| | .
kefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtk....eeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltk

EVEQakaKMHRYWPGK--QPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSAsRDVRQFHYTSWTEENPledglSRCQLIDLIGQVQYWQAESGRHPII
  ..   .....|| |  |   .  |.||   . .     .  ..|   . || ..|  ..|  |  .        .  |  |.| .   | | | .|..
vftd...nirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesa.hnvtlyyykkwnintn.....nkpylkplfgilaknqlengnrPlv

VHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEY
|.||.||||.| |  .   .||.| | ..|.|. ....|.||...|.|| .| ...... ||
vacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 310-567 7.2e-30 98.6 In-house 31-287 (310) alignment 
Range on Protein: 310-567
Range on HMM: 31-287/310.0
TEFQKLSRCINSSLSLNAATHpvNKRKNRYANVLPYDVTRVRLSMQVGVEgSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQ
 ...||    .|||. .| ..  .  ||||..|.  | .||.| ..      ||| |||.     . ||| .| |.  || |||||.... . .|. | .
kqyrkldakqdssltyeaykk..ymhknrysdvvcldtsrvklkidksry.edyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllck

EVEQAKAKMHRYWPGKQ-PITFGSLVV----EMQDKVKSGHLVVRiFKLTNTEV---SASRDVRQFHYTSWTEENplEDGL--SRCQLIdliGQVQYwqA
 .|. . |.  |||      |.| . |    |  .. .   | |  |   |  |    |  .  .     | .    . |.   .|. .    |     |
vgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavt.fvpdnvpvdeqpanlkelrvslikwpnwp..drgvpdekchtv...pqrll..a

ESGRHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVL
.    | .||||||..|..| .|. . |..|.    ||. . . .|. .|   .||. || .  .| .
qvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 310-570 2.8e-20 67.1 In-house 26-279 (303) alignment 
Range on Protein: 310-570
Range on HMM: 26-279/303.0
TEFQKLSRCINSSLSLNAATHpvNKRKNRYANVLPYDVTRVRLSmqvgveGSDYINANYIDGYMAKRTfIATQAPIPETIPDFWRMVWEQNCCTIVTLAQ
 ||.|..  .  |.| |   .  |  |||...|.  | ..|.||       | || |.|..    |.. | || |.. |  |||.|. ||.   .. |  
nefekvvsylppsvsknqfvk..nmdknrfvdvicldhskvkls......dssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvllllt

EVEQAKAKMHRYWPGKQP-ITFGSLVVEMQ--DKVKS-GHLVVRIFKLTNTEVSASrdVRQFHYTSWTEENPLEDGLsrCQLIDLIGQVQ-YWQAESGRH
. |  |   .  .| .|  . |   .. .    .|.     |...  ..| .  .   .   || .|  ..   ||    ...  | |.| . .  |  .
dseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksf..lhvhhykawphnsipsdgs..pkfvkqiwqlqsvlrkysdst

PIIVHCSAGVGRTGVFCAVSILIERLKAE-AMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
| .    .|.||.| |.        |..| | .|. . ....|. |   ||   |. . | .. |..
ptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv
subfamily_PTPRA_pd Subfamily PTPRA 311-569 4.6e-87 287.0 In-house 37-294 (330) alignment 
Range on Protein: 311-569
Range on HMM: 37-294/330.0
EFQKLSRCINSSlSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQE
||. |  .   . .|..|..  ||.|||. |.|||| .|| ||.. ||| |||||| .||||  | .|||.| |  ||. |||||.|||. .||| |.. 
efnalPagpiqa.tlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltel

VEQAKAKMHRYWPGKQPITFGSLVVEMQDKVKSGHLVVRIFKLT----NTEVSASRDVRQFHYTSWTEENPLEDGlsrCQLIDLIGQVQYWQAESGRhPI
 |. . | ..||| .  .|.| . ||..|.. . .. || | ..    .|.  .|| |||||.||| .     ..     ...|. .|.  .  |.  ||
kerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfep...iGmlkllkkvkklnqqsag.pi

IVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEY
.||||||||||| |.... ..||.||| .||||..||.|| ||| ||||. || |.|.|.|||
vvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 311-568 3.8e-76 251.3 In-house 3-253 (284) alignment 
Range on Protein: 311-568
Range on HMM: 3-253/284.0
EFQKLSRCINSSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAqe
||.....   .    . |  . || |||. ..|..| ..|.|   .|.|.|||||| .| ||  |  .|||| | ..|. |||||.||.||.||| |.  
efrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt..

veqaKAKMHRYWPGKQPITFGSLVVEMQDKVKSGHLVVRIFKLTN-TEVSASRDVRQFHYTSWTEENPLEDGLsrcQLIDLIGQVQY-WQAESGRHPIIV
    | |  .||| |  |. .   |...   .|   ||| ..|.. ..    |..||||.  | .    . .    .|. |. .|..  . | .|..|.|
....kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdyps...dlmrlvkkvrhltskenhranivv

HCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLE
|||||||||||. .. .|..|.| | .|||...|..||.||. .||   || |.|  .||
hcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 311-570 3.5e-38 125.9 In-house 16-269 (281) alignment 
Range on Protein: 311-570
Range on HMM: 16-269/281.0
EFQKLSRCINSSLSlNAATHPVNKRKNRYANVLPYDVTRVRLSMQVG-VEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQ
|| .|     | |   .  .|||..||||.|.   |..||.| ...   . .||| ||||   . || .| || |  ||  |||||.|..|  .|| |.|
efsnlpgdppsdlc.tvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcq

EVEQAKAKMHRYWPGKQ--PITFGSLVVEMQDKVKSGHLVVRIFKLTNTevSASRDVRQFHYTSWTEenpLEDGLSRCQLIDLIGQVqywQAESgrHPII
 .|  . |   |.| .    . |  | |. .|      ||   ..|.      .| . .. .  | .    .   |   .. .. ..   .| |   | .
fletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsye..getrlithwlwkewpd...wqvpessevmlkilrki...rars..tppv

VHCSAGVGRTGVFCAVSILIERLKAE-AMVDVFQTVKQLRE-QRPAMVQTKGQYDFCYQVVLEYL
.||||||||.| . || | .. ...  .. |. | | .||   | | |||  || . ..|.|.. 
ihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfg
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 311-570 3.2e-35 116.2 In-house 32-289 (305) alignment 
Range on Protein: 311-570
Range on HMM: 32-289/305.0
EFQKLSRCINSSLSLNAATH-PVNKRKNRYANVLPYDVTRVRLSMQVgveGSDYINANYIDGYM-AKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLA
.. | .|   .   .||     ... ||||..|   | . |.|.       |||| |||.   |  .. ||..| |. .|| .|| || ...   || |.
glakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlc

QEVEQAKAKMHRYWPGK---QPITFGSLVVEMQDKVKSGHLVVRIfKLTNTEVS----ASRDVRQFHYTSWTeenplEDGLSRCQLIDLIgqvQYWQAES
. ||  | |  .|||     .    . .|||     |  .    | ..|  ...     .  ||....| |      . |.  |.|  |           
ktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaei.qitllnltysgdqkmsvrhlqwtewp.....drgvppckltsle...llsairg

GRHPIIVHCSAGVGRTGVFCAVSILIERLKAEA-MVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
 . ||.||||||.||||   |.  ..|..  .     . . || ||.||   .|.  || | ..|.|.|.
skvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 311-372 1.6e-10 35.1 In-house 18-77 (244) alignment 
Range on Protein: 311-372
Range on HMM: 18-77/244.0
EFQKLSRCINSSLSLNAAtHPVNKRKNRYANVLPYDVTRVRLSMQvGVEGSDYINANYIDGY
||  ||      |  ||    .|  |||| |.||.| ||| ||     |||||||||||.| 
efvglsdhtreflqtnav.lsanatknryinilpfdetrvilsss.kkegsdyinanyiqgs
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 312-571 1.9e-56 186.0 In-house 21-294 (301) alignment 
Range on Protein: 312-571
Range on HMM: 21-294/301.0
FQKLSRCINSSLSLNaaTHPVNKRKNRYANVLPYDVTRVRLSMQ--VGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQ
...|..  . | ...  ..  ||. ||. |. .||  |. |. .  . .   .||||.|||||  |. |||.|.|. .|. ||||..|..   .||....
ykelkegedksctvg..lseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtn

EVEQAKAKMHRYWPG--KQPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVS---------------ASRDVRQFHYTSWTEENPLEDGLSRCQLIDlig
. |..|.| ..|||   ..  .|| . |.....      |.| .... ...|               .|.|| |.. |.| ..  . .     | ||   
lkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqvid...

QVQYWQAESGRHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLA
.| . |   |  |..||||..|.|.||.|.||| .|  |||  ||||| .| .| ..| .|.|  || . |.|. .||.
dvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq
subfamily_ptpA1_pd Subfamily ptpA1 312-531 5.2e-46 152.2 In-house 27-257 (418) alignment 
Range on Protein: 312-531
Range on HMM: 27-257/418.0
FQKLSRCINSSLSLNaATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRtFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEV
|. |   .  | . .   .  |  ||||.|.|| . |||.|      |||||||||||||   |. ||.|| |.|.|| ||||||||. |  || |..| 
frlleesvgpsetse.gdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq.fictqgplpntiadfwrmvwenrcriivmlsres

EQAKAKMHRYWPG----K-------QPITFGSLVVEMQDKVKSGH--LVVRIFKLTntEVSASRDVRQFHYTSWTEENPLEDGLSRCQLIDLIGQVQY--
|... |  ||||     .           ||.  ||. . ..     .. |  .||      .||. |..|  | . |  .      ||.  | . |   
encrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirlt..fegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqi

WQAESGRHPIIVHCSAGVGRTGVFCAVSILIERLK
  .     |||||||||||||| ||.  |....| 
ipssdrnvpiivhcsagvgrtgtfctavimmkkld
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 314-572 9.9e-71 233.3 In-house 30-286 (297) alignment 
Range on Protein: 314-572
Range on HMM: 30-286/297.0
KLSRCINSSL--SLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAkrTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEV
.  .|. ..   .   | . ||  |.||.|.||||. ||.| .      |||.|| .. |.     .|.|| | ..|. |||.||....  ||| |... 
eeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddn

EQAKaKMHRYWPGKQPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENpLEDGLSRCQLIDLIGQVQYWQAESGRHPIIVHCS
|. | |  |||. |   |||...|...   .    . | ...|. .  | | |.|.....| ...  |   |  .|..|| .|.    .    |..|||.
erdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdka.verkdsassllklisevrkdfsqnaegPllvhcl

AGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLAS
||||||||....   . . | |  ||.|..||.||..|| .|||| || | |..|||.| |
aGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlealls
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 315-568 1e-58 193.5 In-house 15-264 (283) alignment 
Range on Protein: 315-568
Range on HMM: 15-264/283.0
LSRCINSSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGvegsDYINANYID---GYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEV
| |    .|. . |.   ||||||. ...|.|. ||.|  .      ||||| .|     |  .. .|..|.|. .|. |||.||.... ..|| |..  
lkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklq

EQAKAKMHRYWPGKQPITFGSLVVEMQDKVKSGHLVVRIFKLTNT-EVSASRDVRQFHYTSWTEENPledGLSRCQLIDlIGQVQYWQAESGRHPIIVHC
|. . |  .||| .  . .| . | ... . |  .... . | .     ..  .  . .  |.| ..   .     |.  . .|.  | || . ||.|||
edlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleyge...qaiinslvk.fnkvislqteskkgPivvhC

SAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLE
|.|.|||.||.|.|  .. ...|..||||..|| .||||. .|||..|| . ...|||
stgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 318-382 1.1e-12 41.9 In-house 33-94 (95) alignment 
Range on Protein: 318-382
Range on HMM: 33-94/95.0
CINSSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQvgvEGSDYINANYIDGYMAKRTFIATQ
 . |  .  . .   |  |||. |..||| ||| |. .     |||||| ..|||  |  .||.|
smtsgapytvgsseanipknrflnifpydatrvvlttk...rdsdyinacfvdgyarkncyiaaq
subfamily_PTPN9_pd Subfamily PTPN9 320-570 5.8e-74 243.8 In-house 29-290 (297) alignment 
Range on Protein: 320-570
Range on HMM: 29-290/297.0
NSSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMH
. .  ..|. ...| .||||..|| || ||| |. . . | |||||||..|||  |..||||| |...|. |||||||||.. .||  .. ||. . |  
pveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcg

RYWP--GKQPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEDGLSRCQLIDLIGQVQ---------YWQAESGRHPIIV
.|||   .. . ||.| |.  . ... . .||.....|.. . || |  | ..|| .    ... |  .... . . |          |. .    ||.|
qyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivv

HCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
|||||.|||| |... | ..||. ...|||..|||.||.||  ..||  || |||. |||| 
hcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 321-569 1.4e-62 206.1 In-house 26-276 (287) alignment 
Range on Protein: 321-569
Range on HMM: 26-276/287.0
SSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQvGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHR
|.. . ||..  . .|||||.|||.| ||| || . |  |||||||||. .|  . .|||.|.||. |. ||||.|.|.. ....|...|||.|. | ..
statfkaaeelaavkknryadvlPiddtrvllsae.gelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcyk

YWPGK-QPITFGSL-VVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEE--NPLEDGLSRCQLiDLIGQVQYWQAESGRHPIIVHCSAGVGR
||| . .|.  |   || .. ..|. .  || ..| . |   .| |.|... || ..   |   || |  | |   ...  .  |.  |..||...|.||
ywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvl.dvkqhielardasevGPlvvhddvGiGr

TGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEY
.|.. |. .|..||.    ||| ..| .|||.| |.||.  |. . |. .  |
sGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvty
subfamily_PTPRD_pd Subfamily PTPRD 322-573 3.2e-117 387.5 In-house 37-284 (564) alignment 
Range on Protein: 322-573
Range on HMM: 37-284/564.0
SLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRY
. . .||..|.||.||||||...|| .||.||.  |.||||||||..||||......||||.|..||| ||||||||||..||| | . .|. | |.|.|
qftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkY

WPGKQPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEDGlsrCQLIDLIGQVQYWQaESGRHPIIVHCSAGVGRTGVFC
|| |.. |.|.|.|.......  . ..| |||.... | || |||||.||| ...  | .   ..|.||| .|. .. |....||.|||||||||||.|.
WPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesa...tslLdlirkvraln.epdagPivVhCSaGVGRTGtfi

AVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLASF
......||.|.|..||..|.||.||.||.|||||. || |.....||.||..
vidamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacg
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 322-572 7.6e-64 210.9 In-house 37-290 (325) alignment 
Range on Protein: 322-572
Range on HMM: 37-290/325.0
SLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMV--WEqncCTIVTLAQEVEQAKAKMH
. . ..|..| || |||. ||...| .|| |  .     ||||||.|.  .. | .|.|.||| ..|| |.||.|  |.   |..| .  |... | .  
giakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr...csvvvvlneldlgkdrca

RYWPGK--QPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEDGLSRCQLIDLIGQVQYW-QA-ESGRHPIIVHCSAGVG
 ||| .  .  |||.| |...   .    | |.... ...   .| |.||.. || .    .   .   ...|. .|.   .|   .  ||.||||||||
vywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvG

RTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLAS
||||| ..  .....  |. ||.|. ||.||..||.||.|  || ..|. . |.. |
rtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveayms
subfamily_egg_pd Subfamily egg 322-569 5.4e-30 99.1 In-house 29-269 (307) alignment 
Range on Protein: 322-569
Range on HMM: 29-269/307.0
SLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQakAKMHRY
  ||. |    |. | |   |   |..||.| .. |    |.| ||...|     .|| .|||. .|  ||||||.....  || |.  .|    . . |
eislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyy

WPG--KQPITF--GSLVVEMQDKVKSGHLVVRIFKLTNteVSASRDVRQFHYTSWTeENPLEDGLSRCQLIDLIGQVqywqaesgRHPIIVHCSAGVGRT
||   .... .  ||| .|  .  .    . |. ||    | . .. |   .  .   | . |  |  ... .. ..         .|..|..  || ..
wpkaesdslvtvpGslrienlkvdskadplfrvtklkl..vGgddeerflehwqgd.vnnssdvysplrvlrklrnl........skpvvvqdilGvska

GVFCAVSILIERLKAEA--MVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEY
... |. | .  |         | ..|. || .|.  |..  .| | |..|| .
atlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlff
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 324-569 4.1e-72 237.8 In-house 40-278 (315) alignment 
Range on Protein: 324-569
Range on HMM: 40-278/315.0
SLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWP
 |. | .  ||.|||| |...|| .||.| .    ..|||.|||.||||  || .||.|.| .... ||||.|.|... .|| |.. ||. | |  .|||
pldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywp

GKqPITFGSLVVEMQDKVKSGHLVVRIFklTNTEVSASRDVRQFHYTSWTEENPledGLSRCQLIDLIGQVQYWQAESGrHPIIVHCSAGVGRTGVFCAV
 |  ...| . | .... .  .. || .  . .  .  |.| |.||||| . .      .   |..|| .|. .. .|   .|.||||||||||| |...
dk.kviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgv...pkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitl

SILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEY
. ......|| ..||.. ....|..|  |||.  ||.| |...|| 
davldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 325-573 1.9e-76 252.1 In-house 38-286 (305) alignment 
Range on Protein: 325-573
Range on HMM: 38-286/305.0
LNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPG
..  .. .||.|||.... ..|  |..|. .  .. ||||||.|.|||  | ..|..|.|...|. ||||...|    ||| |.. ||. | | ..|||.
idvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpe

KQPI--TFGSLVVEMQDKVKSGHLVVRIFKLTN-TEVSASRDVRQFHYTSWTEENPLEDGlsrCQLIDLIGQVQYWQAESGRHPIIVHCSAGVGRTGVFC
..     ||...||.... .   .. | .|...  | . || | |.. |.| ..   .       |..|| .||  | ..   |..|||||||||||||.
sktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfa...tsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfi

AVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLASF
||.| .||||.| .||||. .||||..|. ||||. ||.|..... |.. ..
avdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 325-570 1e-44 147.6 In-house 25-295 (297) alignment 
Range on Protein: 325-570
Range on HMM: 25-295/297.0
LNAATHPVNKRKNRYANVLPYDVTRVRLSmqVGVEGSDYINANYID--GYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYW
. .|  .   ||||| ..| .| |||.|    .. ..|||||.|.      |.  .| .| |. .|. |||..|.||.  .|| .|.  |. . |   ||
fssakrnsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapyw

PGK--QPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEEN-P--LEDgLSRC---------------QLID-----LIGQVQYW
|    .  . |..|||   ..   .  | . .|.    | || ||   . || .   |  ||| | |                 |..     .. |..  
psvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdled.lvrfqaqvcscciavpmmlalvemftamvflqlesl

QAESGRH-PIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
.||  |  ...|||||||||.||     .....|. . . ||   ...|||||. .|||  |....|..||. |
raemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
0037934 (Phosphotyrosine protein) phosphatases II 326-570 8.2e-73 240.2 In-house 3-242 (243) alignment 
Range on Protein: 326-570
Range on HMM: 3-242/243.0
NAATHPVNKRKNRYANVLPYDVTRVRLsmqvgvEGSDYINANYIDGYmakRTFIATQAPIPETIPD----FWRMVWEQNCCTIVTLAQEVEQAKAKMHRY
. | .|.|. |||| ..|||| .||.|      |||||||||.|...   ...||||.| |||. |    ||||.||... .||.| ..||  . |...|
siallpenlsknrysdilpydhsrvkl......egsdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPGKQpiTFGSLVVEMQDKVKSGHLVVRIFKLTNTE-VSASRDVRQFHYTSWTEENPLEDGLSRCQLIDLIGQVQY----WQAESGRHPIIVHCSAGVGR
|||..  |.| ..|.. .    .. .|| ..|.|..    .| |...||..| . .. ..  .  ...| . ...     . |... .|..|||||||||
wpgev..tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

TGVFCAVSILIERLkaeaMVDVFQTVKQLREQRPA-MVQTKGQYDFCYQVVLEYL
||...|  .....|     ||....||.||||||  .||| .|| |.|...||.|
tGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 326-570 1.8e-51 169.8 In-house 38-236 (392) alignment 
Range on Protein: 326-570
Range on HMM: 38-236/392.0
NAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAkakmhrywpgk
..| ...|..|||| |.|||| .||.| .   .  |||.|| ||... .....||.|.| . .. ||||||...| .||. ...  |             
tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...........

qpitfgslvvemqdkvksghlvvrifkltntEVSASRDVRQFHYTSWTEENPLEDGlsrCQLIDLIGQVQYwQAESGRHPIIVHCSAGVGRTGVFCAVSI
                                    | | |||.| | ...  .     . |. .| .|.  .  .  ||.|.|||||||||||  ..  
...............................kgddartvaqfhftewPdkdvpkht...ssllkfikevka.dfGqythpliihcsagvgrtgvvisids

LIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
.. . |   |||||. | ..|..|| ||||| || | |  ||| |
vvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 326-372 3.5e-09 30.5 In-house 40-86 (440) alignment 
Range on Protein: 326-372
Range on HMM: 40-86/440.0
NAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGY
. |. | || |||| |.| || .|| |    ||  |||||| ||.| 
diaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi
0040439 (Phosphotyrosine protein) phosphatases II 327-570 5.5e-82 270.4 In-house 5-246 (249) alignment 
Range on Protein: 327-570
Range on HMM: 5-246/249.0
AATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQ
 | .|.|| |||| ..|||| .||.||   |...||||||.|||||  ||.|||||.| |||..|||||.||... .||.| ..||  . | ..||| ..
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplgg

PITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEDGLSrcqLIDLIGQVQYWQAES-GRHPIIVHCSAGVGRTGVFCAVSI
....| ..|.. .  ......|| ..|||.. . || |....||.| . .  ..  .   |.|.| .|. ...|    .|..|||||||||||.|.|  .
sleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfed...lldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

LIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
..|.|. |  ||....||.||.||| .||. .|| |.|...||.|
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0042113 (Phosphotyrosine protein) phosphatases II 327-570 1.1e-80 265.9 In-house 3-243 (245) alignment 
Range on Protein: 327-570
Range on HMM: 3-243/245.0
AATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQ
 | .|.|| |||| ..|||| |||.||   | ..||||||.|.|||  ...|||||.| |||..|||||.||... |||.| .|.|  . | ..||| ..
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplge

PITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEDglsRCQLIDLIGQVQYWQAESGRHPIIVHCSAGVGRTGVFCAVSIL
..|.| ..|.. .  . ....||....||.  . || |...||..| . .. ..     .|.|..  |. ..||.. .|..|||||||||||.|.|. ..
sltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdl...lellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylm

IERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
.|.|..|  |.....||.||.||| .||| .|| |.|...||.|
leqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 327-574 2.2e-79 261.2 In-house 3-246 (250) alignment 
Range on Protein: 327-574
Range on HMM: 3-246/250.0
AATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAkMHRYWPGKQ
 | .| || |||||.....| .|| |  . | . |||||| ...||. ...|||||.|...|| ||||||.|..  ||| |.. .|. |  .|.||| ..
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek

PITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEDGLSrcqLIDLIGQVQYWQAESGRHPIIVHCSAGVGRTGVFCAVSIL
. ..|.. |.. .| . . ...| .||.... . .| |||.|...| .    |   .    ..|. .||  | ..|  |.||.|||||||.| |.|.. .
aekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevata...vLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidav

IERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLASFE
.|||| | .||||. .|.||..|| .|... || |.|...|..| |.|
lerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsve
subfamily_PTPRK_pd Subfamily PTPRK 327-568 4e-77 254.1 In-house 37-275 (314) alignment 
Range on Protein: 327-568
Range on HMM: 37-275/314.0
AATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQ
|| .  |..|||. ..|.|| .||.|    |   ||||||..||.|   . ||.|| |..||. ||||.|...||..|| |.. ||... |  .||| . 
aakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedt

PItFGSLVVEMQDKVKSGHLVVRIFKLTN--TEVSASRDVRQFHYTSWTEEnplEDGLSRCQLIDLIGQVQYWQAEsGRHPIIVHCSAGVGRTGVFCAVS
 . .| . ||. .      ||||||....    ... | ||||....|..    .   |.  |..|. .|. .|.| .  .|.|||||| ||||.|.|..
ev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdh...dvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaid

ILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLE
|... .. | .||||..||.||.... ||.|. || |.|.|.||
ivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 327-571 1.8e-69 229.0 In-house 38-278 (315) alignment 
Range on Protein: 327-571
Range on HMM: 38-278/315.0
AATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPG--
.| ...| .|||| |.||.| .||.| .      |||||| || ..   ...||.|.| . .. ||||||....  ||| ...  |. | |  .|||   
varetinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrk

KQPITFGSLVVEMQDKVKSGHLVVRIFklTNTEVSASRDVRQFHYTSWTEENPlEDGLSrcQLIDLIGQVQYWqAESGRHPIIVHCSAGVGRTGVFCAVS
 . . |||. ||. .    .  |.| .  .  .  .|| | ||..| | ..   .  .|   |. || .|.    ..  ....||||||||||||.... 
adsvefGsikvellsleadtdgvarkl..vtrkseesrtvtqfqftewPdkGv.dkqts..sllklikevkad.ngkkefsllvhcsaGvGrtGvvisid

ILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLA
  ....| . .||||..||.||..|| .|||. .| | |..|||.| 
evvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 327-568 7.1e-49 161.1 In-house 2-239 (239) alignment 
Range on Protein: 327-568
Range on HMM: 2-239/239.0
AATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYM-AKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGK
|| . ||| ||||||.. || .|| |        ||||||.|.  |  . ...||||  .  .  |||||.|..  | || |.  .|  | | |.|||  
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

QpITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEDGLSrcqLIDLIGQVQYwQAESGRHPIIVHCSAGVGRTGVFCAVSI
    .  | | ..        ..| | ...   .  | | |.|.| | ..   .   .   .. |  ..   ..  | .| ..|||||||||| |  .  
t.skycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyata...vlglrrkitk.dslpgarpwvihcsagvgrtgaflvida

LIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLE
.. . | .  ||.|. || .||.|| ||||  || | .  |||
mlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 327-568 1e-48 160.6 In-house 1-238 (239) alignment 
Range on Protein: 327-568
Range on HMM: 1-238/239.0
AATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYM-AKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGK
|| . ||| ||||||.. || .|| |        ||||||.|.  |  . ...||||  .  .  |||||.|..  | || |.  .|  | | |.|||  
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

QpITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEDGLSrcqLIDLIGQVQYwQAESGRHPIIVHCSAGVGRTGVFCAVSI
    .  | | ..        ..| | ...   .  | | |.|.| | ..   .   .   .. |  ..   ..  | .| ..|||||||||| |  .  
t.skycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyata...vlglrrkitk.dslpgarpwvihcsagvgrtgaflvida

LIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLE
.. . | .  ||.|. || .||.|| ||||  || | .  |||
mlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 328-571 4.5e-68 224.6 In-house 38-277 (515) alignment 
Range on Protein: 328-571
Range on HMM: 38-277/515.0
ATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPG--K
|   .| .|||| |.|||| .||.| .      |||.|| || .. . ...||.|.| . .. ||||.|...|  ||. ...  |. | |  .|||    
aqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpg

QPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVsaSRDVRQFHYTSWTEENPLEDglsRCQLIDLIGQVQYWQAESGrHPIIVHCSAGVGRTGVFCAVSI
. . |||. ||.      .  . | ....  .   || | |||.| | ..   ..      |. || .|.  . .   ||.|.|||||||||||....  
dsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkh...tssllklikevkadhgqyt.hpliihcsaGvGrtGvvisids

LIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLA
 . . |   |||||..|...|..|| .|||. || | |..|||.| 
vvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 328-427 1.4e-08 27.8 In-house 22-89 (169) alignment 
Range on Protein: 328-427
Range on HMM: 22-89/169.0
ATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINAnyidgymakrtfiatqapipetipdfwRMVWEQNCCTIVTLAQEVEQakakmHRYWPGKQP
|   .|. ||| |  |    |||.|   .   |||||||                           ||.|| |   || | .  ..       .|| |. 
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddk.....nnfwpeked
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 328-429 1.5e-08 27.6 In-house 21-90 (169) alignment 
Range on Protein: 328-429
Range on HMM: 21-90/169.0
ATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINAnyidgymakrtfiatqapipetipdfwRMVWEQNCCTIVTLAQEVEQakakmHRYWPGKQP
|   .|. ||| |  |    |||.|   .   |||||||                           ||.|| |   || | .  ..       .|| |. 
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddk.....nnfwpeked

IT
  
yq
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 329-571 7.1e-65 213.8 In-house 24-269 (274) alignment 
Range on Protein: 329-571
Range on HMM: 24-269/274.0
THPVNKRKNRYANVLPYDVTRVRLSMQVGVEG-SDYINANYIDGYMAK-RTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQ
. . ...|||| ..|| . .|| |. . . .  |.||||||| ||  . ....||| |.|.|. |||||......  || |..  |. ..| ..|.| ..
dvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdae

PI----TFGSLVVEMQDKVKSGHLVVRIFKLTNTEVsaSRDVRQFHYTSWTEENPLEDglsRCQLIDLIGQVQYWQAESGRH--PIIVHCSAGVGRTGVF
 .    ..| . ......|.  .  || . | ..|   .|.|  . ||.| ...  .|     .|.||. .|.  . |.  .  |..||||||.||||.|
dyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPdd...antlldlvleveesreeenaklapvvvhCsaGiGrtGcf

CAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLA
 |.|| . .|..| .|||...| .|| .|  ||||. ||.. .... .|| 
iaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 330-570 8.4e-60 197.0 In-house 17-264 (270) alignment 
Range on Protein: 330-570
Range on HMM: 17-264/270.0
HPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMA-KRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQ--
.  .|. ||||..||  .|||||.     . . ||||||. |.   |...||...| | |. .||||.||..  .|| ... .|. . |  |||| ..  
aargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepke

--PITFGSLVVEMQDKVKSGHLVVRIFKLTntEVSASRDVRQFHYTSWTEE-NPLEDG--LSRCQLIDLIGQVQYWQAESGRH-PIIVHCSAGVGRTGVF
   ...| . |  . ..|.   ...  .|.  | . .| .  |.|..| ..  | |..  ||  ||. .. .|. .. |  .  |..|||||||||||..
kvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtl

CAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
 |. | .. |. .  ||| . ...||..|.|.||.  || | |..|.|| 
ialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya
subfamily_CG7180_pd Subfamily CG7180 331-571 7.3e-66 216.8 In-house 40-291 (296) alignment 
Range on Protein: 331-571
Range on HMM: 40-291/296.0
PVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKaKMHRYWPGKQPITF
  |. |||. .|.||| .|| |.   | | |||||| |.|... |. .| |.||  ||. .|||.|..... ..| |... ..|| ... ||| |.   .
kenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqy

GSLVVEMQDKVKSGHLVVRIFKLTNT----------EVSASRDVRQFHYTSWTEENPLedGLSRCQLIDLIGQVQYWQAES----GRHPIIVHCSAGVGR
| ..||.  . .  .|. | |||| .          ..   | |..|..| |  |. .   ||   ||.|. .|. |. .      . |..|..| |..|
geifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkv..PlstnalielrrrvrlwrekvdedpeegPvvvvssdGasR

TGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLA
.||..|. . .| .. |  ||||. ||.||..|| .|... .| ..|.|.||.. 
sGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 331-570 6.9e-27 89.1 In-house 33-270 (285) alignment 
Range on Protein: 331-570
Range on HMM: 33-270/285.0
PVNKRKNRYANVLPYDVTRVRLSMqvgvEGSDYINANYIDGY-MAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQ--P
  |   ||||.|   . ||| |         ||| |...      . |.|.|| |.|||. |||.|..... . .. |.  .|    |   |.| |    
eanpdlnryadvrcieetrvvlkn....hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev

ITFGSLVV---EMQDKVKSGHlVVRIFKLTNTEVSASRDVRQFHYT--SWTEENPLEDGLSrcqLIDLIGQVQywQAESGRHPIIVHCSAGVGRTGVFCA
. ||   .   | ...  .|  ..  . ..||| ..|  .   |     | ..   ||      .|.|   |.  . .   .|| ||||||||||  |  
vkfgkyeitlteckeeaiagt.ilnaltvintedasseplymnhvqvpwwpdqlapedarp...mielykwvk..kvnpkekpicvhcsagvgrtatfvg

VSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
.     |.  .  ..... |...|  |   ||.. |. | | |..||.
idyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 332-571 2.3e-34 113.7 In-house 42-272 (288) alignment 
Range on Protein: 332-571
Range on HMM: 42-272/288.0
VNKRKNRYANVLPYDVTRVRLSmqvgVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGK--QPIT
 |  ..|| |.   |.|||.||     .   ||.|| .     || .| .|||.  ||  .|.|. |..   || |.. .|. | |   |.| |  . . 
anptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

FGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRD-VRQFHYTSWTEENPLEDGLSRCQLIDLIgqvqywqaESGRHPIIVHCSAGVGRTGVFCAVSILIE
.| |   ...| .  . .|..  | ....   .  |.. |.  | ..   |. ||  .|.. .        .| ..||.||.|||||||| .  . | .|
igrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl........kslqkPivvhssaGvGrtgtlililiale

RLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLA
 |. .  . . . ...|||.|   .||. || . ...|||.|.
slrlddflgirsllaklreerfkaiqtemqylyvhrcvleell
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 332-559 5.9e-31 102.3 In-house 49-270 (301) alignment 
Range on Protein: 332-559
Range on HMM: 49-270/301.0
VNKRKNRYANVlPYD-VTrvrlSMQVGVEGSD-YINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQ--P
..| |.|| .| | .  |    ...| |.|    | ||.|.     . |||||.|...|  ||| |.   .  .|| |.|.||. . |.. | | |    
lpkdkhryptv.PckPst....avevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisek

ITFGSLVVEM--QDKVKSGHLVVRIFKLTNT-EVSASRDVRQFHYTSWTEENPLEdglSRCQLIDLIGQVQywqaeSGRHPIIVHCSAGVGRTGVFCAVS
.  |   ...  .... . ... | ...... .  |.| |  . |..||...  .   |  .| ||.  |.       ..||.||||||.||.  | .  
ldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPk...shaelfdlmelvk.....ksekPivvhcsaGiGrsvafigte

ILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQY
.|  ...|.  ... ...|.|||.|   |||. | 
ylareveadptieltealkhlrehrwngvqtnsql
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 332-570 1.9e-21 70.8 In-house 50-285 (302) alignment 
Range on Protein: 332-570
Range on HMM: 50-285/302.0
VNKRKNRYANVLPYDVTRVRLSMQvgveGSDYINANYIDGYMAKRTFIATQAPIPETI---PDFWRMVWEQNCCTIVTLAQEVEQAKaKMHRYWP--GKQ
 | .||.  .|  .| ..|.|...      .|.||  ..    .|. | .| |. ..     .|||||..... ..| |..| |  |  .. ..|    .
knlkknqsedvpildsnlvkleae....pdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgd

PITFGSLVVEMQDkVKSGHLVV--RIFKLTNTEVSASRDVRQFHYTSWTEENPLedgLSRCQLIDLIGQVqYWQAESGRHPIIVHCSAGVGRTGVFCAVS
  ..|.. |  .  |.. .  .   .  .   ..| |  .   . | | ... .    .  .||  . .| . . ... .....    |.|| |.| .. 
ykeygkmfvNnrk.VekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvp...vkyaeliktaakv.fakkikadentvivSknGaGRagafltla

ILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
. .|.|.... . . ..||..|.|||..|..  || . | ..| |.
vaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
Y_phosphatase Protein-tyrosine phosphatase 333-568 1.3e-79 262.3 Pfam-A 1-235 (235) alignment 
Range on Protein: 333-568
Range on HMM: 1-235/235.0
NKRKNRYANVLPYDVTRVRLsmqVGVEG-SDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWP--GKQPIT
||.|||| ..|||| |||.|    | || ||||||||..||  |..|||||.|...|| |||||||.... .||.|....|. . |...|||   ... |
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGSLVVEMQ-DKV-KSGHLVVRIFKLTNTEVS-ASRDVRQFHYTSWTEENPLEDglsRCQLIDLIGQVQYWQaESGRHPIIVHCSAGVGRTGVFCAVSIL
.|.. ||.. ..  .. . ..| ..|.... . ..| |.|.|||.|....  |.     .|.||| .|. .. |. ..|..|||||||||||.|.|..||
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpes...pkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldil

IERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLE
.|.|.||  |||.|.||.||.||| |||.  || |.|...||
leqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 333-568 1.3e-79 262.3 In-house 1-235 (235) alignment 
Range on Protein: 333-568
Range on HMM: 1-235/235.0
NKRKNRYANVLPYDVTRVRLsmqVGVEG-SDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWP--GKQPIT
||.|||| ..|||| |||.|    | || ||||||||..||  |..|||||.|...|| |||||||.... .||.|....|. . |...|||   ... |
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGSLVVEMQ-DKV-KSGHLVVRIFKLTNTEVS-ASRDVRQFHYTSWTEENPLEDglsRCQLIDLIGQVQYWQaESGRHPIIVHCSAGVGRTGVFCAVSIL
.|.. ||.. ..  .. . ..| ..|.... . ..| |.|.|||.|....  |.     .|.||| .|. .. |. ..|..|||||||||||.|.|..||
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpes...pkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldil

IERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLE
.|.|.||  |||.|.||.||.||| |||.  || |.|...||
leqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 333-568 1.5e-50 166.7 In-house 3-237 (237) alignment 
Range on Protein: 333-568
Range on HMM: 3-237/237.0
NKRKNRYANVLPYDVTRVRLSMQvGvEGSDYINANYIDGYM-AKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPG-KQPITF
|| ||||.|.  || .|| |    |  |||||||.|..|.  . ...||.| |.  .  |||.|||...|  || |.  .|. . | |.|||  .|| ..
nkiknrygnivaydhsrvvlkga.g.sgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GSLVVEMQDKVKSGHLVVRIFKLTNT-EVSASRDVRQFHYTSWTEENPLEDGLSRCQLIDLIGQVQYWQAESGrhPIIVHCSAGVGRTGVFCAVSILIER
| | | .. | .     || . |..  ..   | . |...||| .    .   .  ..   | .     .|||  | |.||||||||||.|  .  .. .
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesg..pwiihcsagvgrtgiflvidamlrq

LKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLE
 | . .||... |. . |.|| ..||| || | .|..||
akekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
0041856 (Phosphotyrosine protein) phosphatases II 333-570 2.7e-48 159.3 In-house 1-171 (182) alignment 
Range on Protein: 333-570
Range on HMM: 1-171/182.0
NKRKNRYANVLPYDVTRvrlsmqvgveGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAqeveqakakMHRYWPGKQpitfgs
|. |||| ..|||| .|          ..||||||...|..  ..|||||.| ..|..||.||..|... |||.|.          ..||| .       
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

lvvemqdkvksghlvvrifkltntevsaSRDVRQFHYTSWTEENPLEdglsRCQLIDLIGQVQYwqaesGRHPIIVHCSAGVGRTGVFCAVSILIERlka
                             | . |..|..|   .. .      .|.|.| .|.        .|..|||||||||||...|  .....   
............................erlgiqylylpwpDhgvpd....ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl...

eaMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
   |.....||..|..|| ||.|  || |.....||.|
..gvsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 333-410 6.3e-11 36.4 In-house 37-119 (347) alignment 
Range on Protein: 333-410
Range on HMM: 37-119/347.0
NKRKNRYANVLPYDVTRVRLSMQVG-----VEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQE
.  |||  .|   | ||| || .        .   |||| .|    |.. .| || |.|.|. |||.||   .   .||. . 
slsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifep
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 334-571 4.3e-39 128.9 In-house 57-284 (290) alignment 
Range on Protein: 334-571
Range on HMM: 57-284/290.0
KRKNRYANVLPYDVTRVRLSmqVGVEGsDYINANYIDGYmaKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGK--QPITFG
 .|||| .|   |.||| |.   | .| ||. |||..|   | .|| || .. .|. |.|||| ...  .|| | . .|. ||| ..|.| |  . .|||
fkknrykdvvcndktrvilk..dGydG.dyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfG

SLVVEM-QDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPledGLSRCQLIDLIgqvQYWQAESGrhPIIVHCSAGVGRTGVFCAVSILIERL
.. |   ... |  ... ... . . .   .  .. ..  || .       ||   |. ..   .  .  ||  |..||||||.|||| | |. . .. |
eitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksv...alstlallrtl...rilrkasG..pvvvhcsaGiGrtGtfvaievglqil

KAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLA
     .|. ..|. ||. | . ||   ||    ...|..  
ldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGk
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 334-572 6.7e-19 62.7 In-house 44-278 (312) alignment 
Range on Protein: 334-572
Range on HMM: 44-278/312.0
KRKNRYANVLPYDVTRVRLSmqvGVEgSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQ-------
|  ||| |.  .|  |  |.   | |   || ||..        |..||.|. .|.  ||...    ...|. |.  ||..  |  .|            
kdlnrypniqcwdrgrftla...gde.nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdled

--PITFGSLVVEMQDKVKSgHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENpLEDGLSRCqlIDLIGQVQywqaeSGRHPIIVHCSAGVGRTGVFCAVS
    |     .|.  | |  ..  |..|.          . .. ..|| .   . |    .    |.  |.       ..|.| |||||||||| .. . 
hrvyteycteieiggkskd.kithrvlkvvvkatgqesklnhyqwaswpdhg.mpdscdta..lrllsavk.....kdkkpviahcsagvgrtgtlalie

ILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLAS
 .|  |.     .| ..   || .|   |..  || .. ..|||.| |
smiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflys
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 334-416 1.2e-09 32.1 In-house 35-116 (332) alignment 
Range on Protein: 334-416
Range on HMM: 35-116/332.0
KRKNRYANVLPYDVTRVRLSMQVGVEgsDYINANYIDGYMAKRTFIATQAPIPE-TIPDFWRMVWEQNCCTIVTLAQEVEQAKA
   ||   .  .| .|| |. | | .  |. ||...|||  | ..| .|||. . |   ||||| |..   |. . .  |. | 
mdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkr
subfamily_eak_pd Subfamily eak 335-571 3.3e-24 79.9 In-house 54-306 (332) alignment 
Range on Protein: 335-571
Range on HMM: 54-306/332.0
RKNrYANVLPYDVTRVRLSMQVgVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQ--PITFGS
..|   ...|||   |||.     .   ||||  ..     | .| | ..  . .. ||.|| ||.  .|| |...||.   |  .|.| |    . || 
nrn.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGi

LVVEMQDKVKSGHLVVRIFKLTNTEvsASRDVRQFHYTSWTEEN-P-LEDGLSRCQLIDLIGQV---------------QYWQAESGRHPIIvHCSAGVG
| || .. || . | .| ..|.  .   .  |  ...  ||| . | .|| |.  . .  .| .               .|  .     |||  .. |  
ldverkefvkrniletrllelskGn..ethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapii.qsarGsa

RTGVFCAVSILIERL--KAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLA
|.|||  . .||. .  | . .  | . . . ...|   | .. |. | |..||.|| 
raGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyll
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 335-424 8.5e-22 72.3 In-house 49-152 (350) alignment 
Range on Protein: 335-424
Range on HMM: 49-152/350.0
RKNRYANVLPYDVTRVRLS--------MQVGVEGSDYINANYIDGY----MAKRTF--IATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHR
 |||| |.|||. .||.|         ..  ....|||||||.         .  |  ||||||.|.|. ||.... . .   |..|...||.   |..|
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPG
||. 
YWqe
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 335-423 7.1e-15 49.2 In-house 50-154 (349) alignment 
Range on Protein: 335-423
Range on HMM: 50-154/349.0
RKNRYANVLPYDVTRVRLSMQV--------------GVEGSDYINANYID--GYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKM
 |||| ..|||. .||.|   .              .    |||||||.    . ... .||||||.| |. ||....  ..   .. | .. |..  |.
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

HRYWP
..|| 
diywq
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 336-568 2.3e-18 61.3 In-house 22-257 (290) alignment 
Range on Protein: 336-568
Range on HMM: 22-257/290.0
KNRYANVLpYDVTRVRLSMQVGVEGSDYINANYIDgYMAKRTFIATQAPIPET-------IPDFWRMVWEQNCCTIVTLAQEVEQAKAKMH----RYWPG
..|... |    ||| |        .||| ||..  .     .|.||.|  ..       | .|| |. . .   .| | .  |. . . .    .| | 
dqRlevpL.veatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpe

KQP--ITFGSLVVEMQDKVKSGHLVVRIFKLTNTEvSASRDVRQFHYTSWTEENPLEDGLSRCQLIDLIgqvQywqaeSGRHPIIVHCSAGVGRTGVFCA
.    ..|. | |. ..|.|   . .|   ..  .      |    . .|.. |  || ..  .||. .   .       . |.||||  |. |  .. |
svgeelkfkgltvkCkskekeddvetRelvvkfdd.eeeftvtHsllkgWnklnvqedtktllsliqkv...k.....asktpvivHcvdGiSrsAalaa

VSILIERLK-AEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLE
. .    .   .  | . . .|.||.||  ..... .. |   ... 
iilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivl
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 343-440 1.5e-09 32.3 In-house 3-89 (130) alignment 
Range on Protein: 343-440
Range on HMM: 3-89/130.0
LPYDVTRVRlsmqvgveGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQeVEQAkakmHRYWPGKQPITF--GSLVVEMQDK
|...|.|..        | .||||...      . .. ||.|. .|  |||.|. |.    .| |   ||.       |||  .|. .    ..| . |.
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgs.veee....deywpdsePlewyeediivtltdr
0044763 (Phosphotyrosine protein) phosphatases II 344-569 1.3e-34 114.8 In-house 1-170 (178) alignment 
Range on Protein: 344-569
Range on HMM: 1-170/178.0
PYDVTRVRLSMQVGVEGSDYINANYIDGYmakrtFIATQAPIpetiPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQPitfgslvvemqdkvks
|.| ||| ||.  |.|.||||||..|...     ......|     .|......|... .||.|..|.|  . |...||| .                  
pldrtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag................

ghlvvrifkltntevsasrdvRQFHYTSWTEENPLEdglSRCQLIDLIGQVQYWQAESGrHPIIVHCSAGVGRTGVFCAVSILIERlkaeaMVDVFQTVK
                      |.... .   .. .   .. .. ...  .. ...|.| .|..|||||||||.|...|  .....      ..... ..
.....................iqylhipipDhgvpd...llehflefvefieealdekg.gpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaie

QLREQRPaMVQTKGQYDFCYQVVLEY
..||.|| .|.. ||. ..|.. |..
lvrerRp.ivpnpgqlrqLyefelrl
0046846 (Phosphotyrosine protein) phosphatases II 352-571 1.6e-42 140.6 In-house 3-174 (176) alignment 
Range on Protein: 352-571
Range on HMM: 3-174/176.0
LSMQVGVEGSDYINANYIDGYMakrtFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQPITFgslvvemqdkvksghlvvrif
| . .  ...||||||.|.|..    .||||.|.|.|..||..|..|... ..|.| .||| .. |...|||  .   .                     
lrllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.....................

kltntevsasrdvrQFHYTSWTEENPLEDglsrCQLIDLIGQVQYWQAESgrHPIIVHCSAGVGRTGVFCAVSilieRLKAEAMVDVFQTVKQLREQRP-
              |.... | . .. ..     .|..|. ... .. |   .|..||||||.||||...|       |. |  ..|.......||||| 
..............qylhlpwpDhgvpdl....elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRpl

AMVQTKGQYDFCYQVVLEYLA
 .||| .|| |.|...|..| 
gavqtpeQyrflyefellllk
0051429 (Phosphotyrosine protein) phosphatases II 359-572 2.1e-53 177.0 In-house 2-227 (272) alignment 
Range on Protein: 359-572
Range on HMM: 2-227/272.0
EGSDYINANYIDGYMA---KRTFIATQAPIPETIPDFWRMvWEQNCCTIVTLAQEVEQAKAKMHRYWP------------GKQPITFGSLVVEMQDKVKS
. |.||||....||     .........| | |. ||||. .|... |||.| .|.|... | .||||            . ..|..| |.| .. ..  
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

GHLVVRIFKLTNT-EVSASRDVRQFHYTSWTEENPLEDGlsRCQLIDLIGQvqywqaesgRHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVD-----
 . ..| . ||..   ...| |...|||.|   .  ..    ..|..|. .          .|..||||||..|||...|. .|.... .|..||     
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYllt

---VFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLAS
   ....|..||.|||..||| .|| |.|...||.| |
nlyleeaveelraqrpgavqteeqylflyeallellrs
0043147 (Phosphotyrosine protein) phosphatases II 359-564 8.7e-43 141.3 In-house 3-155 (172) alignment 
Range on Protein: 359-564
Range on HMM: 3-155/172.0
EGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEveqakakmhrywpgkqpitfgslvvemqdkvksghlvvrifklTNTEV
||||||||.|.|.|   . |||||.| ..|..|||||..|... .||.| ..                                           ...  
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

SASRDVRQFHYTSWTEENPLedglSRCQLIDLIGQVQYWQAESGRHPIIVHCSAGVGRTGVFCAVSILIerlkaeAMVDVFQTVKQLREQRPAMVQTKGQ
  .| . |..|..|   ..     .  .|.... ... ..|.|  .|..|||||||||||...|  ...        ......|...||.|| .||...|
llerlgiqylylpwpDhgvp....llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsq

YDFCYQ
| |.|.
yrflyy
0036282 (Phosphotyrosine protein) phosphatases II 360-564 1.1e-46 154.0 In-house 1-164 (174) alignment 
Range on Protein: 360-564
Range on HMM: 1-164/174.0
GSDYINANYIDGYMAKRTFIATQAPIPetipdFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGkqpitfgslvvemqdkvksghlvvrifkltnTEVS
|||||||...|...  . .||.|.| .     ||.|..|... |.|.| .|.|  . |...|||                                .  .
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lred

ASRDVRQFHYTSWTEENPLEDGLsrcqLIDLIGQVQYWQAESGRHPIIVHCSAGVGRTGVFCAVSILIERLKaEAMVDVFQTVKQLREQRPAMVQTKGQY
 .| . |..|. |   .. ..      |.... .|. ...|.. .|..|||||||||||...|  ... .|. | .||....|..|| ||| |||| .||
lerlgiqylylpwpDhgvpdlsi....llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQy

DFCYQ
 |.|.
rflyy
0051082 (Phosphotyrosine protein) phosphatases II 360-567 2e-35 117.0 In-house 2-150 (151) alignment 
Range on Protein: 360-567
Range on HMM: 2-150/151.0
GSDYINANYIDGYmakrtFIATQAPipetIPDFWRMVWEQNCCTIVTLAQEVEQAkaKMHRYWPGKQpitfgslvvemqdkvksghlvvrifkltntevs
 |||||..|..|.     ......|     .||.....|... |||.| .|.| .  ....|.|  .                                 
lsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

asRDVRQFHYTSWTEENpledglsRCQLIDLIGQVQYWQAESGRHPIIVHCSAGVGRTGVFCAVSILIERlkaeamVDVFQTVKQLREQRPAMVQTKGQY
  ..|.......|.. .         ...| . ..  . .. . .|..||||||.||||...|. .....      |.........|..|| .||.. |.
..ievlhipildwpdpg.......lplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqf

DFCYQVVL
 |.....|
lfqlfall
0049260 (Phosphotyrosine protein) phosphatases II 368-564 3.8e-38 125.9 In-house 1-144 (152) alignment 
Range on Protein: 368-564
Range on HMM: 1-144/152.0
YIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWpgkqpitfgslvvemqdkvksghlvvrifkltntevsasrdvrQF
.||||. .. |||||.| |.|..|||||..|... |||.| ...| .| |...|.                                           |.
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

HYTSWTEENPLEDGLSRCQLIDLIGQVqywqAESGRHPIIVHCSAGVGRTGVFCAVSILIerlkaeAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQ
... |   .. ..     .|...| .     |..  .|..|||||||||||...|  ...        |.....|...||.|| .|...||. |.|.
lhlpwpDhgvpdlsqlllflllfiekl....aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 370-472 1.8e-12 41.3 In-house 230-328 (440) alignment 
Range on Protein: 370-472
Range on HMM: 230-328/440.0
DGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAkakMHRYWPGK-QPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEvsASRDVRQFH
.||  | .||||| |.  |. ||||.| . .  ||. | |  ...      ||| . . .||| . |  .   .   . || ..|   |     ..||| 
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndkt...csiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkyke..evheirqfe

YTSW
  .|
vqtw
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 374-565 8.7e-27 88.6 In-house 3-199 (199) alignment 
Range on Protein: 374-565
Range on HMM: 3-199/199.0
AKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQPIT--FGSLVVEMQDKVKSGHLVVRIFKLTN--TEVSASRDVRQFHY
..| .|||| |. ||. |||.||||     || . ..  . .| .  |||  .  |  .||| |  .  .     ..  . |||  |   ..|.. .. .
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TSWTEENPLEDGLSRCQLIDLIGQVQYWQAEsGRHPIIVHCSAGVGRTGVFCAVSILIERLK--AEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQV
||| |    .  |    ..      . .. |    |.||||| | | |||| |. | .   .    ..||.|.  |.||. |  .. .  .|.| |||
tswkekttpnvalfvgfvvasrevskkyeqe.kdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 375-565 1e-26 88.4 In-house 3-198 (198) alignment 
Range on Protein: 375-565
Range on HMM: 3-198/198.0
KRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQPIT--FGSLVVEMQDKVKSGHLVVRIFKLTN--TEVSASRDVRQFHYT
.| .|||| |. ||. |||.||||     || . ..  . .| .  |||  .  |  .||| |  .  .     ..  . |||  |   ..|.. .. .|
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWTEENPLEDGLSRCQLIDLIGQVQYWQAEsGRHPIIVHCSAGVGRTGVFCAVSILIERLK--AEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQV
|| |    .  |    ..      . .. |    |.||||| | | |||| |. | .   .    ..||.|.  |.||. |  .. .  .|.| |||
swkekttpnvalfvgfvvasrevskkyeqe.kdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 382-560 4.3e-12 40.1 In-house 97-278 (302) alignment 
Range on Protein: 382-560
Range on HMM: 97-278/302.0
QAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGK--QPITFGSLVVEMQ---DKVK----SGHLVVRIFKLTNTEVS--ASRDVRQFHYT
  |  .|.  .| .. . | . .| |.. ||. . |.  |.  |  . ..||   |.     ....      ....   ...|...     . |  ....
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

SWTEENPLEDGLSRcqlIDLIgqvQYwqAESGRHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYD
.| .    ..  .    .|..   ..   || .. ..||||||||||| . |.   |.  . . . |. . |. .|. |   ||.. |  
awpdhGapkeayta...ldil...kf..cesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqli
subfamily_hpo-7_pd Subfamily hpo-7 387-570 2.6e-12 41.2 In-house 45-227 (263) alignment 
Range on Protein: 387-570
Range on HMM: 45-227/263.0
ETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQ--PITFGSLVVEMQdKVKSgHLVVRIFKLTN--TEVSASRDVRQFHYTSWTEENPLEDGL
.||. |....  ..  ..| |.   |... |  .|.| ..     .  . |    ||.|  ....  .|..   |    ..|... |. | |.|  |.  
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvctt.kvqs.dvllktlellstlgeKkkthtvkhysykgWiekndpelar

SRCQLIDLIgqvqywqAESgrHPIIVHCSAGVGRTGVFCAVSILIE----RLKAEA--MVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
.  .....         .|  ....||||.|.||.  |  . ..       |.      .|  . ...||..|.. ..|  |  |   .||...
eilnilkva.......rns..kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfv
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 388-570 2.7e-13 44.6 In-house 40-221 (255) alignment 
Range on Protein: 388-570
Range on HMM: 40-221/255.0
TIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQP--ITFGSLVVEMQDkvKSGHLVVRIFKLTNT--EVSASRDVRQFHYTSWTEENPLEDGLS
|.  |....  ..  ..| |.   |... | ..|.| ..     .  . |   .   | . |.|  ..| |  |    ..|. ..|. | |.|  |.   
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

RCQLIDLIgqvqywqAESgrHPIIVHCSAGVGRTGVFCAVSILIE----RLKAE--AMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
  ... ..        .|  ....||||.|.||.  |  . ..       |.    . .|  . ...||..|.. ..|  |  |.  .||...
ilnilkvv.......rds..ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
0048179 (Phosphotyrosine protein) phosphatases II 397-564 2.2e-20 68.3 In-house 26-139 (144) alignment 
Range on Protein: 397-564
Range on HMM: 26-139/144.0
WEQNCCTIVTLAQEVEQAKAKMHrywpgkqpitfgslvvemqdkvksghlvvrifkltntevsasrdVRQFHYTSWTEENPLEDGLSRCQLIDLIGQVqy
....  |...|. | |..  . .                                            . |.....|   .. ..    ......| ..  
kklgittvinlteeyepeflere............................................giqylhlpwpDhgvpdllellleflefieea..

wQAeSGrHPIIVHCSAGVGRTGVFCAVSILIerlkAEAmVDVFQTVKQLREQRPAMVQTKGQYDFCYQ
 .. .| .|..|||||||||||...|  ...     .  ..........|..|| .|.. ||. |...
.le.eg.gpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfLle
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 413-568 5.5e-09 29.9 In-house 144-300 (332) alignment 
Range on Protein: 413-568
Range on HMM: 144-300/332.0
QAKAKM-HRYWPGKQP-ITFGSLVVEMQDKVKSGHLvvRIFKLTNTEVSASRDVRQFHYTSWTEENPLEDGLSR-CQLIDLIGQVQYWQAESGRHPIIVH
. |||. ...|| |.    | .| ..  |     |.  . |.|| ||    ..   .|.  |.. . | . .      | |       ..     ||.. 
elkakicrkfwpekrskkdfpalsiqasddhsethm..ktfnltvtekkqdhqtvlmhfyewadasklpeymldmrasiklqyirsskktgvcigpimlv

CSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLE
|..|| .  ..... |.. |.  |  | . .|.  .. ||   ..| | |  . .....
catgvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpystacemlmk
0048076 (Phosphotyrosine protein) phosphatases II 428-569 5.7e-22 73.4 In-house 11-142 (145) alignment 
Range on Protein: 428-569
Range on HMM: 11-142/145.0
ITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEDGlsrCQLIDLIGQVQYWQAESgrHPIIVHCSAGVGRTGVFCAVSILI
. .||| . .. .    . . ... ||...   .| . |..|..|   .. ..     .|.... ... ...|   .|..|||||||||||...|  ...
lylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdll...ellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylml

ErlkaeAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEY
.       |.........|.||| .|.. ||. |.|...||.
l.....lgvsleealelvrsqrpgavpnpgqlrflyefelel
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 460-570 1.3e-19 64.9 In-house 87-194 (440) alignment 
Range on Protein: 460-570
Range on HMM: 87-194/440.0
ASRDVRQFHYTSWTEENPLEdglSRCQLIDLIGQVQYWQAESGRHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQY
 || ..|.|| .| ..   .       .. .| .|.  | ..|  |..||||||.|||||  ||  ..   |    .|.|  .. .|..|| ||||  ||
esrtlkqyhyqgwpdkgvpk...fagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqy

DFCYQVVLEYL
 | ...||| |
afvheavlegl
PTPc_DSPc_SM00012 464-568 1.7e-33 110.3 In-house 2-105 (105) alignment 
Range on Protein: 464-568
Range on HMM: 2-105/105.0
VRQFHYTSWTEENPLEDGlsrCQLIDLIGQVQYWQAESG-RHPIIVHCSAGVGRTGVFCAVSILIERLKAE-AMVDVFQTVKQLREQRPAMVQTKGQYDF
|...|||.|....  |..     ...|. .|. .. .|. ..|..|||||||||||.|.|..||...|..|   ||.||.||.||.||| ||||. || |
vkhyhytgwpdhgvPees...dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylf

CYQVVLE
.|...||
lyralle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 464-570 9.7e-18 59.0 In-house 217-344 (350) alignment 
Range on Protein: 464-570
Range on HMM: 217-344/350.0
VRQFHYTSWTEE----NPLE--DGLS-RCQLIDLIGQVQYWQAESgRHPIIVHCSAGVGRTGVFCAVSILIE-------------RLKAEAMV--DVFQT
| |...  | .     || .    |  . .|||     .. . .    ||.|||||||||||.....  |..             .|.  |..   ....
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnar.sspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

VKQLREQRPAMVQTKGQYDFCYQVVLEYL
|..||.||  |||.. |. |.|. .| | 
vnelrkqrismvqnldqfifiYeallfyf
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 485-571 8.6e-14 45.6 In-house 248-345 (349) alignment 
Range on Protein: 485-571
Range on HMM: 248-345/349.0
CQLIDLIGQVQYWQAESgRHPIIVHCSAGVGRTGVFCAVSILIE----------RLKAEAMV--DVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLA
 .|||     .|....    ...|||||| |||||.. . .|..          ..| .|.    .. .| .|| || .|||   |....|. .|.|.|
ndliddlfarlyldtdq.lstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyfa
0038934 (Phosphotyrosine protein) phosphatases II 486-565 4.2e-10 35.1 In-house 98-172 (194) alignment 
Range on Protein: 486-565
Range on HMM: 98-172/194.0
QLIDLIGQVQYWQAESGRHPIIVHCSAGVGRTGVFCAVsILIERLKAeamvDVFQTVKQLREQRPAMVQTKGQYDFCYQV
.| . .  |. . .|.  . . ||| ||.||||...|   ||.||.     .. . .. .|| || .... ....  .. 
illrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa.YLiyrlgm....saeeAialfrekRpgaipnqdyleallkr
subfamily_PTEN_pd Subfamily PTEN 487-558 4.2e-08 28.4 In-house 97-168 (184) alignment 
Range on Protein: 487-558
Range on HMM: 97-168/184.0
L-IDLIGQVQYWQAESGRHPIIVHCSAGVGRTGVFCaVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQ
|  ... ... | .|. .. ..||| || |||||   |. |...|. | . .. .  .. | .    |.   |
lleeivediekwleedkknvvvvHCkaGkGRtGvli.vayllkslllekaeealelfaeaRtknkkgvtiPsq
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 487-571 6.4e-06 19.0 In-house 227-310 (346) alignment 
Range on Protein: 487-571
Range on HMM: 227-310/346.0
LIDLIGQVQYWQAeSGRHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLA
.| .| |    .       . |    | ||.  |      |..|      .... .|....|||  |..  ||   | .|..|.|
iikmihqflsekq.vqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyia
PTEN_1 489-554 4e-07 25.0 In-house 115-177 (196) alignment 
Range on Protein: 489-554
Range on HMM: 115-177/196.0
DLIGQVQYWQ-AESGRHPIIVHCSAGVGRTGVFCAvSILIERLKaeamVDVFQTVKQLREQR-PAMVQ
| . ..  |  . . .. ..||| ||.||.|. .| . |... |     .. .... .||.| |....
dicksfiewllsdpngnvVlVHCkaGlgRsGtvva.ayLmykgk....ltadeAlelvrekRppgapn
PTPc_motif_SM00404 494-549 6.4e-06 21.1 In-house 76-121 (140) alignment 
Range on Protein: 494-549
Range on HMM: 76-121/140.0
VqywqaESGRHPIIVHCSAGVGRTGVFCAVSILiERLKAEaMVDVFQTVkqlREQR
.     |. .. ..||| ||| |.. .... .. .. . . . .... |   .|.|
a.....ekkggkvlVHCqaGvSRSatliiaYlm.ryrqls.laeayefv...kerR
subfamily_CG42327_pd Subfamily CG42327 501-571 1.5e-17 58.2 In-house 245-316 (319) alignment 
Range on Protein: 501-571
Range on HMM: 245-316/319.0
SGRHPIIVHCSAGVGRTGVFCAVSILIERLKAE-AMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLA
. . |..|||| ||||||.  |  | |..|.     ||. |.| ..|..|   |.|| ||.| |.|. || .
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak
subfamily_PTPDC1_pd Subfamily PTPDC1 505-565 1e-09 33.1 In-house 116-171 (182) alignment 
Range on Protein: 505-565
Range on HMM: 116-171/182.0
PIIVHCSAGVGRTGVFCAVSI-LIERLKAEamvdvfQTVKQLREQRPAMVQTKGQYDFCYQV
 . ||| || |||||  |. .   .||.||      ...| .|..||  .||..| ... . 
kvavhChaGlGrtGvliacylvyakrltae......kaiklvrskrpksiqtreqvelvkef
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 507-570 1e-15 51.8 In-house 2-65 (69) alignment 
Range on Protein: 507-570
Range on HMM: 2-65/69.0
IVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
.||||.| |||| | |. . . |.|.| .||.|  |. .|  || ||  . .| | .  . | |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 507-570 1.3e-15 51.4 In-house 1-64 (69) alignment 
Range on Protein: 507-570
Range on HMM: 1-64/69.0
IVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
.||||.| |||| | |. . . |.|.| .||.|  |. .|  || ||  . .| | .. . | |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
subfamily_ptpA1_pd Subfamily ptpA1 537-568 2e-06 21.8 In-house 365-396 (418) alignment 
Range on Protein: 537-568
Range on HMM: 365-396/418.0
DVFQTVKQLREQRPAMVQTKGQYDFCYQVVLE
..|  | .|||||| |||   || |||. .|.
nlfsivlklreqrpgmvqqleqylfcyktild