Gene NvecPTP-sf6-1 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily NvecPTP-sf6
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP065_AA protein Get Run
NvecP065_AA_3-278 phosphatase_domain Get Run
NvecP065_AA_287-571 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1-315 2.2e-164 541.1 In-house 2-318 (318) alignment
Range on Protein: 1-315
Range on HMM: 2-318/318.0
ISIDDFEQHVARMRRSGDLFFTTEYERI-PVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAET
||..|.|.||.|.|.||.|....||||. ...|.||...||.|||..||||.||.||||.|||||..|.|.||||||||...||||..||||||.||.||
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

CRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGSLSYEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFV
..|||||||||||..|.|||...||...|...||||.|| ||....|.|.. .||. |..|...|.|......|||.|.|.|||||.|||.|...||..|
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlv

RDSTRAD-PPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSASDLRSHIRRLQE
|....|. ..||||.||||||||||||.||..|..|..|..|..||....|..||..||||||||.||.||.|.||.|..||.||..||||||.||.|.|
rqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelre

QDPESGYTPMFTEFQKL
||||||.|.|..|||.|
qdpesgttemdaefqrl

subfamily_PTPRD_pd Subfamily PTPRD 1-318 4.3e-152 502.6 In-house 5-322 (564) alignment
Range on Protein: 1-318
Range on HMM: 5-322/564.0
ISIDDFEQHVARMRRSGDLFFTTEYERIPVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETC
|.......|||... ..|| |..||..|  ....| ...  |.|..|||| ||||||||||.|. .| ..|||||||.|. |||...||||.|||||||.
ipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaeti

RDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGSLSYEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVR
.|||||||||||.||.|||.|.|. ..||..|||..|. .|...|||| . .||. |..||......  ...|.|.|||||||||||||.| ..||...|
edFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlir

DSTRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSASDLRSHIRRLQEQD
..... .|.|||.||||||||||||||||||.||..|.||||||| ..|..||..|| |||||.||||||.|.|.|. .|.|| ....|..|...|.|..
kvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLaeve

PESGYTPMFTEFQKLSRC
.....| . .|||.|. .
edtemtgleleFqrLata

subfamily_PTPRG_pd Subfamily PTPRG 1-291 1.5e-113 374.9 In-house 1-301 (563) alignment
Range on Protein: 1-291
Range on HMM: 1-301/563.0
ISIDDFEQHVARMRRSGDLFFTTEYE---RIPVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGS-DYINANFLPGYRRDNAYIAAQGPL
. ...|..||| .  .||  |. |.|   .  ......|.|| .| |..||||.||||||.|||||..  .. .. ||||||.. ||.. .|.||.||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

AETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGSLSYEDITVTLDSVTELTPYIVRTLSVQR------EGCDDVRQVKQFHFTSWPDHGVPT
..|. |||||.||||. .|.|.|||.|| | || .|||. .|. |. ..||| .   |. | ||||...       . ||....|.|.|.|.|||||||.
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe

SVCNLLAFVRDSTRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSASDLR
.    | ||. | .| .  |||.|||||||||||||.||.| .|.||..|..|...||. ..| .|| .|||| ||||.|||||.|| |.||| .|....
hslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqve

S
.
e

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1-313 4.2e-111 366.0 In-house 5-319 (319) alignment
Range on Protein: 1-313
Range on HMM: 5-319/319.0
ISIDDFEQHVARMRRSGDLFFTTEYERIPVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETC
| ........ ... .|.  .  |.. .  .. .| ...  . |..|||| ||.|||..||.|..... .|||||||.|. ||.. ...||.|.||..| 
ievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlenti

RDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGSLSYEDITVTLDSVTELTPYIVRTLSVqREGCDDV--RQVKQFHFTSWPDHGVPTSVCNLLAF
 ||||||||..| ...|||.|.|. . |. .|||.    .|  ..|||..  ||  ||.| |.. ..  ..|  |.||.|..|.||||.||..   ||..
edfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPekatslldl

VRDSTRADP-PGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSASDLRSHIRRLQ
...  ..   . .||.||||||||||||||||.|.||....|| ..|.  .||.||  ||.|||...||.||..|||.|. .|.||    |||  ...|.
lkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqla

EQDPESGYTPMFTEFQ
|.....| | .  |||
ekvadtgetglerefq

subfamily_PTPRB_pd Subfamily PTPRB 1-282 1e-107 354.6 In-house 7-290 (293) alignment
Range on Protein: 1-282
Range on HMM: 7-290/293.0
ISIDDFEQHVARMRRSGDLFFTTEYERIPV-PEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAET
|....||.||..|..  || |. |||..    .. . . .  .||. |||| ||..||||||||.. .||.||||||||..|||.  . .||.|||| ||
iklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpet

CRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSR-GSLSYEDITVTLDSVTELTPYIVRTLSVQRegCDDVRQVKQFHFTSWPDHGVPTSVCNLLAF
  ||||||||..|..|.|||.| |. . || .|||.   .  | ||.||| . .||. ...|.|....   .. |.|.|.||||||||||| .  .||.|
vddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldf

VRDSTRAD--PPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGET
||   .|      ..|.||||||||||||||| .| .||.|.|| .|||.|.|. ||..|||.||||.||||||...|| . ..|.
vrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkkee

0051299 (Phosphotyrosine protein) phosphatases II 1-277 7.1e-106 349.1 In-house 5-286 (288) alignment
Range on Protein: 1-277
Range on HMM: 5-286/288.0
ISIDDFEQHVARMRRSGDLFFTTEYERIPVPE-HVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAET
||.......| .....|  ..  |.|...    ..| ...| | |..|||| .|..||||||||.......|||||||....||......||.|||| .|
isveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpnt

CRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGSLSYEDITVTLDSVTELTPYIVRTLSVQRE----GCDDVRQVKQFHFTSWPDHGVPTSVCNL
. ||||||||||.|.|.|||.| |. | |||||||..||| |.|||||| |...|  |.|||| |..     |.. .|.|..||.|.|||||||.|.  |
vedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspell

LAFVRDSTRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAI
|.|.|.  .| ..| ||.|||||||||||||||..|..|.|...|..||.|..| .||..|. ||||..||.|...|||...
ldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

0043336 (Phosphotyrosine protein) phosphatases II 1-275 2.4e-97 321.0 In-house 2-275 (278) alignment
Range on Protein: 1-275
Range on HMM: 2-275/278.0
ISIDDFEQHVARMRRSGDLFFTTEYERIPVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETC
||. |........ ...   .  |.|...   . | ...| | |..|||| .|..||||||||.... ...||||||....||.. ...||.|||| ||.
isvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetv

RDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPsRGSLSYEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVR
 ||||||||....||.|||.|.|. | ||||||| .||| |.|.|||| ....|  |.|||| | . |.. .|.| ..|...|||||||.|.  || |..
edFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflk

DSTRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLD
.  .| ..  ||..||||||||||||||.....|.|.. |..||..  |..||..|  .|||..||.|...|||.
avrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1-297 6.1e-92 303.0 In-house 4-303 (305) alignment
Range on Protein: 1-297
Range on HMM: 4-303/305.0
ISIDDFEQHVARMRRSGDLFFTTEYERIPVPEHVTAThSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETC
|..||.....  .|   |  . ..|. ..  |. .     . .|..|||. .|. .|..|..|.  |... ||||||... ||.| ..||.||||| .| 
ialddlaayikearvysdkgleaqykslyeeeesidv.gkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntv

RDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGSL--SYEDITVTLDSVTELTPYIVRTLSVQR-EGCDDVRQVKQFHFTSWPDHGVPTSVCNLLA
.||||...|   .||.|||.|.|  .||| |||| . .    .....|.| | .. . || | |..   .. .. |.| |...|.|||||||..   || 
adfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatslls

FVRDSTRADPPGAG-PMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSASDLRSHIRRL
.... ...   . | |..|||||||||||.||..|..|.....|..||. . . .||..|  |||| .|| |.|||| . |..|.|.   |.|| .. .|
likrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnkl

Q
.
k

subfamily_Ptp69D_pd Subfamily Ptp69D 1-296 2.9e-90 297.5 In-house 4-305 (307) alignment
Range on Protein: 1-296
Range on HMM: 4-305/307.0
ISIDDFEQHVARMRRSGDLFFTTEYERIPVP-EHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAET
|.||| |. .   .|  |  .. |||...    . ... |    |. |||| .|.|.|. ||||.  . .  ||||||.|. ||.  . .||||.|. .|
iaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveat

CRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGSLSYEDITVTLDSVTELTPYIVRTLSVQREG-----CDDVRQVKQFHFTSWPDHGVPTSVCN
  |||||..||.. .|.||.||.|  |.|||.|||      |.|| |.| |  . . || |.|.| . .      .| |.| |.|.|.|.|  || .   
igDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevarg

LLAFVRDSTRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSASDLRSHIR
|| ...          .|.||||||||||.|.|. .|..|||...|..|||  .|  ||..|||.||  .||.|.. |||| .  |.|. .  || ..|.
llklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaie

RL
||
rl

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1-289 2.4e-89 294.4 In-house 6-290 (315) alignment
Range on Protein: 1-289
Range on HMM: 6-290/315.0
ISIDDFEQHVARMRRSGDLFFTTEYERIPVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETC
| .|..  .||. . |    |  .|| ||  .      . .  |..|||||||.|||.|||.|   | .|.|||.||||..|| . . |||||||.... 
ipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasv

RDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRgSLSYEDITVTLDSVTELTPYIVRTLSVQREgcDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVR
.||||.|.|..  .|.||||| |. . |. .||| .  . |  ||||. |    | | ||||||  .  |..|.| |.|.||||| ||| .  .|. ..|
kdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtlsvvfg..dnirevvqlhytswpdmgvpkytiplmnlir

DSTRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETsASDL
   . .   .|..||||||||||||||| .| .|.|.. |. .|.  |.  .|. |  |||. .|| ||.||||.... |.|   | ||
tvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsi.aqdl

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1-284 9.3e-74 243.0 In-house 2-285 (287) alignment
Range on Protein: 1-284
Range on HMM: 2-285/287.0
ISIDDFEQHVARMRRSGDLFFTTEYERIPV--PEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQdfedEPGSDYINANFLPGYRRDNAYIAAQGPLAE
|... | . ||. .. |.  |.. .  .     ..   ||.. . |..|||. .|. .|  || |.    .   ||||| |. ||. ..|.|.|..|...
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfn

TCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGSLSYEDITVTLDSVTELTPYIVRTLSVQREG-CDDVRQVKQFHFTSWPDHG-VPTSVCNLL
| |.||......|  .|.||...||  ...| ||||.  |... . ...| . .  . ||.|.| |....  .| .||||...|.|...| |..    ||
tarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtill

AFVRDSTRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETET
 . .       .| ...|||||..|||...|. ... ... ..| ..|..  .   |  .  .||| .||.|| |..|  . |.|| .
vieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1-282 8.4e-72 236.5 In-house 2-288 (290) alignment
Range on Protein: 1-282
Range on HMM: 2-288/290.0
ISIDDFEQHVARMRRSGDLFFTTEYERIPVPE-HVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPG--SDYINANFLPGYRRDNAYIAAQGPLA
| .|.| ..||  .  |.  | ...... . | . |.|. | . |...||. ||| ||  |. |..  ...    .|||| .. ||. ...|||.|||. 
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

ETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGSLSYEDITVTLDSVTELTPYIVRTLSVQREGC-DDVRQVKQFHFTSWPDHG-VPTSVCNL
.| .|||...|....  |.|||| .|  ..|| ||||.... .|. ....| . ..|. || |.|.|. .   .. ..|.|...|.|...| |.     |
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtil

LAFVRDSTRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGET
|.. .       .| ...|||||..|||...|..... ... . |  .|..  . ..|  .  .|||.||| .|.. .| .. | ||
lvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfet

subfamily_PTPRA_pd Subfamily PTPRA 2-302 1.2e-103 341.5 In-house 15-320 (330) alignment
Range on Protein: 2-302
Range on HMM: 15-320/330.0
SIDDFEQHVARMRRSGDLFFTTEYERIPV-PEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETC
 ....|. . .        |  |.. .|  | . |   .    |..|||..||. ||.||| |.  | .. |||||| |. ||.. . .||||||..|| 
pvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetv

RDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGSLSYEDITVTLDSVTELTPYIVRTLSVQ--REGC--DDVRQVKQFHFTSWPDHGVPTSVCNLL
 |||||.|||.| ||.|||.|||| ..|||||||. |...| .|.|... .|.|  | || . ||   ...  ...|.|.||||||||| |||.    .|
edfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGml

AFVRDSTRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSASDLRSHIRRL
 ...   . ..  |||.||||||||||||||||.| .|.... |. ||. .||. ||  |  ||||..|| ||. .||.  . |.||  .| | .|...|
kllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlqkl

QEQDPE
... ..
ynkitg

0050432 (Phosphotyrosine protein) phosphatases II 2-280 5.6e-102 336.4 In-house 27-302 (308) alignment
Range on Protein: 2-280
Range on HMM: 27-302/308.0
SIDDFEQHVARmrRSGDLFFTTEYER-IPVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLqdfedEPGSDYINANFLPGY--RRDNAYIAAQGPLAE
|..|. ... .    .  .. .|.|.   |... . ...| | |..|||| .|..||||||||     ..|||||||.. .||  ......||.|||| .
svldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpn

TCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSR---GSLSYEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNL
|. ||||||||||.|.|.|||.| |. | |||||||.    ||| |...|||| |...|  |.|||| ..  |....|.|..||.|.|||||||.|.  |
tvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeil

LAFVRDSTRADPPgaGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISG
|.|..   .  |.  ||.|||||||||||||||..|..|.|...|..||... | .||..|. ||||..||.|...|||. . . 
ldflelvrkslpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklk

subfamily_PTPRK_pd Subfamily PTPRK 2-313 6.7e-100 329.0 In-house 5-313 (314) alignment
Range on Protein: 2-313
Range on HMM: 5-313/314.0
SIDDFEQHVARMRRSGDLFFTTEYERIPVPehVTATHslDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCR
 ..|  |..| ..|.    |  ||| ..      |..  .  |..|||. .|.|||.|||.|.  ...| ||||||... .|.| .|.|..|||| || .
rvadllqsiallkraegygfkeeyeslfeg..wdaak..kdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvk

DFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGSLsYEDITVTLDSVTELTPYIVRTLSVQR--EGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFV
||||.|...|. .|.|||.|.|  | || .|||  ..  |.|| |.| ... |. ..||...|..   | ...|.|.||.|..||||.||.|   ||..|
dfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklv

RDSTRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSASDLRSHIRRLQEQ
|     ....||..||||||| |||||||.||..|. |..|..||.   | ||| ..  ||.||.||.||.|..|.| . |||   .|....     .. 
rrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesirl

DPESGYTPMFTEFQ
||..  . .  |||
dpqtnssqlkeefq

subfamily_PTPN9_pd Subfamily PTPN9 2-275 7e-82 269.8 In-house 2-288 (297) alignment
Range on Protein: 2-275
Range on HMM: 2-288/297.0
SIDDFEQHVARMRRSGdlfFTTEYERIP-VPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETC
.|......|  ....|    . ||. |   | . |...|  ..| .|||| ... ||..||.|.  .... ||||||||. ||.. .|.||.|||| .|.
eieelvayvkekgkrG...lskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktv

RDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWP--SRGSLSYEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAF
.|||||||||. ..|.| | . || | ||.||||  .  | .. |..|.  .| |   | ||.| ...   .. |.|  | |.||||.||| |  .|| .
sdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldv

---VRDS----------TRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLD
   ||.           . . .|   |.|||||||.||||||| .|. |....|. |||.   |..||  |  ..||..|| | . |.|.
lekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle

0039614 (Phosphotyrosine protein) phosphatases II 3-277 8.8e-95 312.8 In-house 16-289 (297) alignment
Range on Protein: 3-277
Range on HMM: 16-289/297.0
IDDFEQHVARMRRSGDLFFTTEYERIPVPEHvTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDE-PGSDYINANFLPGYRR-DNAYIAAQGPLAETC
.. ..... ......  .. .|.|...   .   ...| |.|..||||..|..||||||||.....  ..||||||....||.. ....||.|||| ||.
lsvldlllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetv

RDFWRMVWEQNSRTIIMLTNLKERCRdKCAQYWPSRGSlSYEDITVTLDSVTELTPYIVRTLSVQRegCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVR
 |||||||||....|.|||.|.|. | |||||||..|.  |.|.|||| .|..|  |.||||.|..   . .|.|..|..|.||||||| |.  || |..
edFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslelllefle

DSTRADP--PGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAI
   .|    |. ||..||||||||||||||... ||.|...|..||.|  |..||..|. .|||..||.|..||||. .
lvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 3-287 3.1e-79 261.2 In-house 12-294 (297) alignment
Range on Protein: 3-287
Range on HMM: 12-294/297.0
IDDFEQHVARMRRSgDlFFTTEYERIPVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRdnAYIAAQGPLAETCRD
. ||   | . |.. | .|. |.  .|  .  ..| . . || .|.|| ||. || |||||.  .|.| |||.|| |..|..    .|. | |  .|  |
lsdfatlvqknrht.d.vfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvad

FWRMVWEQNSRTIIMLTNLKERCRdKCAQYWPSRGSLSYEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPT--SVCNLLAFVR
||.||....  ||.||....|| . |||.||. .|. .. |..|.| ||.| . .| |.|.|...     | |||..|..|||. |.   |.  || .. 
fWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklis

DSTRADP-PGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSAS
.          ||..|||.||||||| .. || .. ....||.|||.|.|. ||..|  .|||..|| |.. |.|.|..| .|.  ||
evrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqas

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 3-290 1.3e-77 256.1 In-house 4-292 (439) alignment
Range on Protein: 3-290
Range on HMM: 4-292/439.0
IDDFEQHVARMRRSGDLFFTTEYERIPV--PE-HVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAET
 |.|..|| .. .  . .|. ..| |    |. .. |.   .  .| |||| ...|.||.|| ||.    | | |||||.. ||  |. |||.|||  ||
rdefqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkket

CRDFWRMVWEQNSRTIIMLTNLKERCRdkcaqYWPSRGSLSYEDITVTLDSVTELTPYIVRTLSV--QREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLA
. ||||.|.|... ||.||||| |  .     |||| .   | ||.|  |   ||  |..| . |  .|. ..  | | |||...|||. ||.    .| 
tddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvld

FVRDSTRA-DPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSASDLR
|.|    | |    ||.||||||||||||| | .|. |.|.. |. ||| | |. ||..|. |||.  ||.||..|.|. |. |.. ..  ...
flrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefk

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 3-94 1.2e-16 54.6 In-house 7-95 (95) alignment
Range on Protein: 3-94
Range on HMM: 7-95/95.0
IDDFEQHVARMRRSGDLFFTTEYERIPVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDepgSDYINANFLPGYRRDNAYIAAQG
.  |  ||  |    |  |  |.  |..    . |      |  |||..||. || .|| |    |   |||||| |. || | |.||||||
vsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkrd...sdyinacfvdgyarkncyiaaqg

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 3-81 2.8e-11 37.4 In-house 8-84 (440) alignment
Range on Protein: 3-81
Range on HMM: 8-84/440.0
IDDFEQHVARMRRSGDlfFTTEYERIPVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLP
. || ..|   |||    |  |.  .|      .  .  | |. |||| ||.||||||| |.. .  | |||||| .. 
vadfadyvqnnrrsra..fedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyin

0040438 (Phosphotyrosine protein) phosphatases II 4-315 4.2e-104 343.5 In-house 3-314 (317) alignment
Range on Protein: 4-315
Range on HMM: 3-314/317.0
DDFEQHVARMRRSGDLFFTTEYERIPVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDF
 |..... .. .|.   .  |.|...   . | .... |.|..|||| .|. ||||||||....  ..||||||.. .|... ...||.|||| .|. ||
ldlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedF

WRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGSLSYEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDST
|||||||....|.|||.|.|. | |||||||....| |.|.|||| |..||  ...||| |.  |....|.|..||.|.||||||| |   ||.|..   
wrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavr

RADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSASDLRSHIRRLQEQDPES
.| ... ||..||||||||||||||....||.|...|..||.   | .||..|. .|||..||.|..||||. .  ..| ..||.| ... .|.. .. .
ealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplald

GYTPMFTEFQKL
..... .|.. |
dvklkekelkll

0045450 (Phosphotyrosine protein) phosphatases II 4-277 4.7e-93 307.5 In-house 12-304 (307) alignment
Range on Protein: 4-277
Range on HMM: 12-304/307.0
DDFEQHVARMRRSGDLFFTTEYERIPVPEH---VTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDE-PGSDYINANFL--------PGYRRDNAYIA
 .....|... ...   .  |.|...  ..    . ...| |.|..|||| .|..|||.||||.. ... ..||||||..         .||......||
lkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIa

AQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRG-SLSYEDITVTLDSVTELTPYIVRTLSVQRE-GCDDVRQVKQFHFTSWPDHGVP
.|||| ||. |||||.|||....|.|||.|.|. | |||||||. | .| |...|||| |...|  |.|||| |..  |.. .|.|..||.|.|||||||
tqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvp

TSVCNLLAFVRDSTR--ADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKT---VDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAI
.|.  ||.|..   .  .. |. ||..||||||||||||||....||.|...|.|   ||.|  |..||..|  .||...||.|...|||. .
psfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 4-315 1.8e-81 268.4 In-house 6-315 (315) alignment
Range on Protein: 4-315
Range on HMM: 6-315/315.0
DDFEQHVARMRRSGdlFFTTEYERIPVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDF
 .|   | . |..   .|. |.  .| |.    . . ...|..|||| ||. .|..||||.  .|.| |||||| .....  |.||||.||||  .  ||
aqfpafvnknrhta..lfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddf

WRMVWEQNSRTIIMLTNLKERCRDKCAQYWPS--RGSLSYEDITVTLDSVTELTPYIVRTLsVQREGcDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRD
||||....  ||.|.|...|  . ||.||||     |  .  | |.| |.   |  ..| | | |.. .. |.| ||.|| |||.||.  .  || ....
wrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrks.eesrtvtqfqftewPdkGvdkqtssllklike

STRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSASDLRSHIRRLQEQDP
    . .   ...||||||||||| .| || ...||.....||.. || .||..|  .||||..| ||.||.|. .   .|      .  |.. |.    
vkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhtsvd

ESGYTPMFTEFQKL
 || . |  ||..|
gsgrskmtkefetl

subfamily_PTPN14_pd Subfamily PTPN14 4-276 6.7e-62 204.2 In-house 10-295 (300) alignment
Range on Protein: 4-276
Range on HMM: 10-295/300.0
DDFEQHVARMRRSGDLFftTEYERIPVP-EHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEpGSDYINANFLP--GYRRDNAYIAAQGPLAETC
|.  ... .  ..| .|  |||||||   |. . . .  |.|..|||. ... |...||.|.  ...  ..||||  .      ..  ||.|||||  |.
dkrakilekkleegkvf..teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltv

RDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSR----GSLSYEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLL
.|||.|||||. . |.|||. .|  ..|. .|.|.      .. ..   ||   ... . .| ..| ..     . |.|  . .| |||||||  | . |
qdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgfl

AFVRD--STRAD----P---PGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDA
 ....  | |              |..|||||||||||  |. |.... .. ....||   ...||. | |.|||  || |....|.  
syLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 5-315 3.9e-66 218.1 In-house 8-274 (392) alignment
Range on Protein: 5-315
Range on HMM: 8-274/392.0
DFEQHVARMRRSgDLfFTTEYERIPVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFW
.|   | . |.|  | |. |.  .| |.    | .  ..|..|||| ||. || .||||.  .| | |||.|| ..|..  ..||||.||| | .  |||
qfpafveknrhs.al.ffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfw

RMVWEQNSRTIIMLTNLKERCrdkcaqywpsrgslsyeditvtldsvteltpyivrtlsvqreGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTR
|||...|  ||.|.|.|||                                              ||.| | ||||| |||..||  ...|| |...   
rmvfqenvttiamvtklkegd..........................................kgddartvaqfhftewPdkdvpkhtssllkfikevka

ADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSASDLRSHIRRLQEQDPESG
     . |...||||||||||  | || .. . .. . ||.. ||. .||.|  ||||..|| ||. |.|. ..  .|      .  |.. |.      .
dfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlstssdGdv

YTPMFTEFQKL
 . .  ||..|
rskqlkefrsl

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 5-275 6.3e-58 190.8 In-house 4-291 (301) alignment
Range on Protein: 5-275
Range on HMM: 4-291/301.0
DFEQHVARMRRSGdlfFTTEYERIPVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFE--DEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRD
| ..||| ..  .   |  .|...   |. ..| .|.  |.. ||. ||. ||. |. |.  .  |    .||||... ||.. ...||||||. .| .|
dlgthvaakhsnk...feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvd

FWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRG--SLSYEDITVTLDSVTELTPYIVRTLSVQR-EGCD--------------DVRQVKQFHFTSWPD
|||..|..   .|.|.|||||. ..|| ||||.    | ..  .|||| . . .  ...| |.|.  .| .              . ..| |.. |.||.
fWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpq

HGVPTSVCNLLAFVRDS-TRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLD
.||       |  . |   |   .| ||.|||||..|.|.|... ... | |   |  ||. . . ..|| .  .|.| .||..|.|..  
dGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidm

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 6-322 5.9e-83 273.7 In-house 7-322 (515) alignment
Range on Protein: 6-322
Range on HMM: 7-322/515.0
FEQHVARMRRSGdlFFTTEYERIPVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWR
|   |.. |.    .|. |.  .| |.    | . . .| .|||| ||. || .||||.  .|.| |||.|| ..|..  |.||||.|||.  .  ||||
fPafvnknrhtt..lfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWr

MVWEQNSRTIIMLTNLKERCRDKCAQYWPS--RGSLSYEDITVTLDSVTELTPYIVRTLSVQREgcDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDST
.|...|  ||.|.|.|||  . ||..|||     |. .  | | | |.   |  | |.| | ..  ||.| | ||||| |||.|||     || ....  
lvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkg..ddsrtvtqfhfteWPdkGvpkhtssllklikevk

RADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSASDLRSHIRRLQEQDPES
      . |...|||||||||| .| || .. .... ..||.. ||  .|..|  .|||..|| ||..|.|. .   .|      .  |.. |.      
adhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgr

GYTPMFTEFQKL-SRCINSS
| . |  ||| | | | .  
grskmtkefqtlkslcpdpp

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 6-304 1.1e-78 259.6 In-house 10-315 (325) alignment
Range on Protein: 6-304
Range on HMM: 10-315/325.0
FEQHVARMRRSGDLFFTTEYERIPVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWR
. .|| . .   .  |. |.. .|  . .. . .  | |. |||. |.||.|.||| |.  .|.| ||||||..|  ... . ..||| ||..|  |.||
lvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWr

MV--WEqnsRTIIMLTNLKERCRDKCAQYWPSR--GSLSYEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVP---TSVC---NL
.|  |.    ......|  .   |.||.||| .   |  .  . | | .. |.. |. | | |..    . | ||||.. ||.| ||.   ...    .|
lvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilql

LAFVRDSTRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSASDLRSHIRR
.  | .  .|.  ...|..|||||||||||.|| .  .|... ||  |||.|||  ||..|  ||.|  |||.|..|| .|..||.|.   | . ...  
vkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklss

LQEQDPESG
|||..| . 
lqernpltq

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 7-283 2.2e-95 314.4 In-house 15-296 (298) alignment
Range on Protein: 7-283
Range on HMM: 15-296/298.0
EQHVARMRRSGDLFFTTEYERIPVPEH----VTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRD
.. .| ... .   ...|..|.   ..     . . .  | |..|||| .|.|.|.||| |.. ...  |||||| || .|.. ||.||.|.|| ||  |
qklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetved

FWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGSLSYEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDS
|||||.|... ||.|||||.|  . |. .|||..|.  |..|||.| |  | . .|||.| |...  .. |.|.|.|||||||.|||.  . .|...|. 
FWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkv

TRaDPPGAG--PMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETE
 .  .  ||  |..|.|||||||.||||.|| .|.....|..||..  | .||..|  .||||.||.||..| |.|. |...|
ra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnde

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 7-278 4.5e-90 296.6 In-house 3-277 (281) alignment
Range on Protein: 7-278
Range on HMM: 3-277/281.0
EQHVARMRRSGDLFFTTEYERIPV-PEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWR
..|....... .  |..||| .     . ||| |  . |..||||.||||||..|||... |..  .|||||||.|||. ...|||.|||. ... .||.
rkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWq

MVWEQNSRTIIMLTNLKERCRDKCAQYWPSRG-SLSYEDITVTLDSVTELTPYIVRTLSVQREGCDDvRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTR
|||||. ..|.|.|.  |  . || .|||    .|.| |.||.  . .| . || |.....||...  |.|.|...|.|||||||..  .|| | .. ..
mvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresget.reveqlaytaWPdhGvPattkellefrkevlk

ADPPG-AGPMVVHCSAGVGRTGTFIVIDVMLQQIHEE-KTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAII
.. .    |.|.|||||||||||.| .| .......| ...|.   |  ||..|||||||  || |.. |.|||. 
ltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 8-277 7.2e-96 315.6 In-house 10-279 (288) alignment
Range on Protein: 8-277
Range on HMM: 10-279/288.0
QHVARMRRSGDLFFTTEYERI-PVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRM
..||.. ...   |. ||. . .. .. . | .  .||..|||| ||..||. ||||.. |.|.|.|||||... |......|||.|||||.|  |||..
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

VWEQNSRTIIMLTNLKERCRDKCAQYWPSRGS-LSYEDITVTLDSVTELTPYIVRTLSVQREGcdDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRA
|.|... ||.|||.| |. . || .|||. .    | ..|||| .. ||. ...|.| .....  . ....|.....||||||| |  .||...|    |
vyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkk..teleitqyqylaWpdhgvPeskapllellrqvkva

DPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAI
..  .||..||||||||||||||..| ......||...|..|.|. ||..|.|.|||..||.||...||. |
nqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli

subfamily_CG7180_pd Subfamily CG7180 9-281 2.7e-61 201.8 In-house 8-294 (296) alignment
Range on Protein: 9-281
Range on HMM: 8-294/296.0
HVARmRRSGDLFFTTEYERIPVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVW
 | . ||   . .  |.. .|  |  .  . |   |. |||....| ||. || |. .. |  |||||| .  .. ....||  ..|  ||  .|||.|.
lvdk.rrkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvy

EQNSRTIIMLTNLKERCRdKCAQYWPSRGSLSYEDITVTLDSVTELTPYIVRTLSVQRE----------GCDDVRQVKQFHFTSWPD-HGVPTSVCNLLA
.... ....||.  .  . .. .||| ..   | .| | . .. ...    ||. ....             ..| ||.|..| |.  . || |   |. 
deeisavvvLtktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalie

FVRDS----TRA-DPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGE
..|       .. . |  ||.||..| |..|.| .. ||. |.....|. ||. ..| ||||.|. .|.. ..| .| | ||.|.. . 
lrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 19-293 2e-66 218.8 In-house 9-282 (283) alignment
Range on Protein: 19-293
Range on HMM: 9-282/283.0
LFFTTEYERIPVPEHVTATHSLDpVNQHKNRYINIVAYDHSRVKLQDFEDepgsDYINANFLP---GYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTI
  |   ..|. ||.  .  .| |  |..|||. .||..|  ||.|.        ||||| |.|    |..|. ||.||.|| .| .|||.||....  .|
klfrevlkrlsvpdldadiasad.enkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitai

IMLTNLKERCRDKCAQYWPSRGSLSYEDITVTLDSVTELTPYIVRTLSVQRE-GCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADPPGAGPMV
.|||.|.|  | ||.||||.|||  | . ||||   |    .|.. | .. .  . .   .  . .  | . |  . .  |. | .  .       ||.|
vmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPiv

VHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSASDLRSHI
||||.|.|||..|| . . ....  |  ||.   |  .| .|  .||| .|| ..|.. |.  . |.|.  | || | |
vhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdlqsti

0049772 (Phosphotyrosine protein) phosphatases II 19-276 2.3e-47 157.6 In-house 21-279 (314) alignment
Range on Protein: 19-276
Range on HMM: 21-279/314.0
LFFTTEYERIPVPEHVTATHSLDPVNQHKNRYINIVAYDhSRVKLqDFEDEPGSDYINANFLPGYrrdNAYIAAQGPLAETCRDF----------WRMV-
|...  .  . |.   | . . ...|..||||..|. .| .||.| ....  |||||||... |.   ...||.|||| .|. ||          |||| 
lllvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvl

-WEQNSRTIIM---------------------LTNLKERCrdkcaqywpsrG------SLSYEditvtldsvteltpyivrtlSVQREGCDDVRQVKQFH
 ...|.|.| |                     |..| ..            .         ..                    ... .. .  |.. ...
rgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng...........neptaadlellk....................eelydpelferlgikyl

FTSWPDHGVPtSVCNLLAFVRDSTRAdpPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHeektVDILGFVSTLRRHRN-----LMVQTEQQYIFIHDALL
 . .||...| .   ...|..   .|  .  || .|||.||.||||||.|.. .. . .    |..   .. .|. |       .... .||.||..|||
ripvpDgsap.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefileall

DA
..
ey

subfamily_PTPN6_pd Subfamily PTPN6 21-275 1.6e-81 268.7 In-house 28-295 (306) alignment
Range on Protein: 21-275
Range on HMM: 28-295/306.0
FTTEYERIPVP---EHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQdFEDEPGSDYINANFLPGY--RRDNAYIAAQGPLAETCRDFWRMVWEQNSRTI
|. |.|..      . .. ...  | |..|||| ||. .||.||.|.  .. |||||||||.. .     |..|||.|| | .|  |||||||..||| |
feeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvi

IMLTNLKERCRDKCAQYWPSRGSL-SYEDITVTLDSVTELTPYIVRTLSVQ-REGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADPP----G
.|.|.  || ..|||.|||.  .  .| .|.||  | ..|. ||.|.|||. ..  .. |.| |.||.||||||||..   .|.|..| .|         
vmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeae

AGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEK---TVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLD
|||.|||||||.||||||||||..|..|....    .||  .| ..|..|. .||||||| |.. |.  
agpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 22-297 2.4e-89 294.8 In-house 37-311 (319) alignment
Range on Protein: 22-297
Range on HMM: 37-311/319.0
TTEYERIPV--PEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLT
  |. |..   ..  . |..  . |. |||.|||.|.|...|||.  . | .|||||| |. ||.| . |||||||| .|  |||||.||.|. ||..||
evefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt

nlkercRDKCAQYWPSRGSLSYEDITVTLDSVTELTPYIVRTLSVQREG-CDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRD--STRADPPGAGPMVVH
      .|||.|||| ..   .|   | .|||.|   |.|| . . ..|   |.|...||||  |||.||| .  .|. .|.     .    .  ..|||
......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvh

CSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSASDLRSHIRRLQ
|||||||||..||.||.|....||| ||.  ||  ||. || .||   || ||. |||.  . | .. .  |. .....| 
csaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleels

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 23-275 4.6e-45 148.7 In-house 10-257 (267) alignment
Range on Protein: 23-275
Range on HMM: 10-257/267.0
TEYERIPVPEHVTAT--HSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEpgsdYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTN
 |.| |    . ..|   |.   || .||. . . ||..|| |.. |.|    |||| .. ||.. ||.|. |.||  |  ||. .. .|.  .|..||.
kefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltk

LkerCRDKCAQYWPSR--GSLSYEDITVTLDSVTELTPYIVRTLSVQREgCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADpPGAGPMVVHCS
      |.  ..|| .   .  |.|.||      |   | . || .. .  .  ..|  ...  |          . |  .    . .  |  |.||.||
v...ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfk.nesahnvtlyyykkwnintnnkpylkplfgilaknqle.ngnrPlvvacs

AGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLD
.||||.|||.||| .|... .| ..||  |.  .|  |  .|.| ..||.||. | .
dGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae

0046845 (Phosphotyrosine protein) phosphatases II 24-281 5.7e-99 326.3 In-house 5-278 (284) alignment
Range on Protein: 24-281
Range on HMM: 5-278/284.0
EYERIPVPEHV---TATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDE-PGSDYINANFLPGY-----RRDNAYIAAQGPLAETCRDFWRMVWEQNSRT
|.|...   .    . ...| | |..|||| .|..||||||||. .... ..||||||....||     .. ...||.|||| .|. ||||||||||.|.
efeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrv

IIMLTNLKERCRDKCAQYWPSRG-SLSYEDITVTLDSVTELTPYIVRTLSVQREG-CDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADP--PGA
|.|||.| |. | |||||||. | .| |.|.|||| |...   |.||||.....| .. .|.|..||.|||||||||.|. .||.|.|.  .. .  || 
IVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgg

GPMVVHCSAGVGRTGTFIVIDVMLQQIHEEK---TVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGE
||.|||||||||||||||..|..|.|...|.   .||.|. |. ||..|. ||||..||.|...|||... .. 
gpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 24-274 1.6e-76 252.1 In-house 10-265 (274) alignment
Range on Protein: 24-274
Range on HMM: 10-265/274.0
EYERIPVPEhvTATHSLDPVNQHKNRYINIVAYDHSRVKL-QDFEDEPGSDYINANFLPGYRR-DNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNL
|.  .|.    .  .   . .|.|||| .|.  ..||| | ..  ... |.|||||.. ||.. ..||.|.||||..|  |||||....... |.|||.|
eflelPlnf..dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltkl

KERCRDKCAQYWPSRGSL----SYEDITVTLDSVTELTPYIVRTLSVQRegCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDS--TRADPPG-AGPMV
||. ..|||.|.| . ..     |.|. .. ....|   | ||.|...   . . |.|| . .|.|||| .| .. .|| .|..   .| .    ..|.|
keaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlky..lerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvv

VHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALL
||||||.|||| || |.. ..|..||..||.|. |. || .|  ||||..|| .|| || 
vhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc

subfamily_CG42327_pd Subfamily CG42327 24-199 3.1e-38 126.2 In-house 10-187 (319) alignment
Range on Protein: 24-199
Range on HMM: 10-187/319.0
EYERIPvpEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRR-DNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLK
|.. .|    .. .  . .  . |.|.||.|   ..|| ||   |.. . |..|... ||.  .| ||||| .| ..  ||||.||||.||.|. ||.| 
efrdlP..qliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdls

ERCRDKCAQYWPSRGS----LSYEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFtSWPDHGVPTSVCNLLAFV
|   ..||.|.|.. .     .| || |||        |.. || ..|   .  |..  . .  |.. .||..   |.| .
elGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliaml

0036941 (Phosphotyrosine protein) phosphatases II 27-289 9.9e-98 322.4 In-house 22-289 (297) alignment
Range on Protein: 27-289
Range on HMM: 22-289/297.0
RIPVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLqdfeDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCR
  |.    . ...| | |..|||| .|..|||.||||    |..|||||||....||......||.|||| .|. ||||||||||...|.|||.| |. |
llpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgr

DKCAQYWPSR--GSLSYEDITVTLDSVTE--LTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTR--ADPPGAGPMVVHCSAG
 |||||||.   .|| |.|.|||| ||..  |. |..||| |.  |....|.|..||.|.|||||||.|.  ||.|..   .  .  |. ||..||||||
ekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaG

VGRTGTFIVIDVMLQQIH---EEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSASDL
|||.||||..|.||||..   .|..|||| .| .||..|. .|||..||.|...|||. . ...|  ....|
vgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllkl

0045098 (Phosphotyrosine protein) phosphatases II 27-276 3.1e-84 277.9 In-house 16-271 (278) alignment
Range on Protein: 27-276
Range on HMM: 16-271/278.0
RIPVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKlqdfedepgsDYINANFLPGYrrDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCR
 .. .   . |..| . |..|||| .|..|||||||          |||||....||  ....||.|||| .|. |||||.||.....|.|||.|.|. |
llllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgr

DKCAQYWPSRGSLSYEDITVTLDSVTELTPYIVRTLSVQRE----GCDDVRQVKQFHFTSWPDHGVPTSV--CNLLAFVRDSTRADP-------------
 |||||||..||| |.|.|||| |...|  |..||| |.        .  | |...|...|||||||..     .| ...   .|               
ekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllll

PGAGPMVVHCSAGVGRTGTFIVIDVMLQQIheEKTVDILGFVSTLRRHRNL-MVQTEQQYIFIHDALLDA
.. ||..||||||||||||..... ||...  |..||.|  |..||..|.  .||...||.|....||. 
dsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllel

0047943 (Phosphotyrosine protein) phosphatases II 29-277 9.7e-95 312.4 In-house 23-272 (273) alignment
Range on Protein: 29-277
Range on HMM: 23-272/273.0
PVPEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLqdfeDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDK
......| ...| | |..|||| .|..||||||||    ...|||||||....||.. ...||.|||| .|. ||||||||||.|.|.|||.| |. | |
slkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrek

CAQYWPSRG---SLSYEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADPP--GAGPMVVHCSAGVGR
||||||. |   || |...|||| |...   |.|||| ... |....|.|..||.|.|||||||.|.  || |...  .|     . ||.||||||||||
caqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgR

TGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAI
|||||..|..|.|...|..||.|  |  ||..|  ||||..||.|...|||. .
tgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 30-278 1.7e-21 71.1 In-house 35-280 (303) alignment
Range on Protein: 30-278
Range on HMM: 35-280/303.0
VPEHVTATHSLDpvNQHKNRYINIVAYDHSRVKLQDfedepgSDYINANFLPGYRRDNAyIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKC
.| .|.  . ..  | .|||.....  |||.||| |      | || |..|    . .| | .| ||. |. |||.|. ||. . ...|    |  .   
lppsvsknqfvk..nmdknrfvdvicldhskvklsd......ssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklgg

AQYWPS-RGSLSYEDITVTLDS---VTELTPYIVRTLSVQREgcDDVRQVKQFHFTSWPDHGVPTS----VCNLLAFVRDSTRADPPGAgPMVVHCSAGV
   .|  .  | .|. .. .     |     . .. |||     |    ..  |. .||   .|.     . . .  ..   |   ..  | |    .|.
dsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsng..dyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdst.ptvymslsgc

GRTGTFIVIDVMLQQIHEEK-TVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAII
||.||| ...     .|.|. ..|..  . ..|  |   ||   |. ...  | . ..
gragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 31-188 1.4e-18 61.4 In-house 83-235 (244) alignment
Range on Protein: 31-188
Range on HMM: 83-235/244.0
PEHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDfeDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERcrdkcA
|.      ...| | .|||    . .| .|| |       |  |||| |.    |   || .| |||.|  |||.|. |.    ...|  ..|       
pdpsvmkdafnpnnswknregaglpfdfnrvplsk..gsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....d

QYWPSRGSLSY--EDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGV
.|||    | .  |||||||    |.       | .. .  .  . .  |  . ||  | 
eywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgt

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 32-297 6.9e-88 289.8 In-house 13-275 (284) alignment
Range on Protein: 32-297
Range on HMM: 13-275/284.0
EHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTnlkercRDKCAQ
.  . |..  . |. |||...|.|.|...|||.    | .|||||| |. ||.| . |||.|||| .|  |||||.||.|. ||..||      .|||.|
ngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsq

YWPSRGSLSYEDITVTLDSVTELTPYIVRTLSVQREG-CDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRD--STRADPPGAGPMVVHCSAGVGRTGTFI
||| ..   .|   | .|||.|   |.|| . . ..|   |.|...||||  |||.||| .  .|...|.     .    .  ..||||||||||||..|
ywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyi

VIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSASDLRSHIRRLQ
|.||.|....||| ||.  ||  ||. || .||   || ||. |||.  . | .. .  |. .....| 
vldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleels

subfamily_egg_pd Subfamily egg 32-274 2.4e-28 93.7 In-house 28-267 (307) alignment
Range on Protein: 32-274
Range on HMM: 28-267/307.0
EHVTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERcrDKCAQ
.... |....  |..| |   .   | |||||.  .     |.| || . |    | .| || || .|  ||||||.... . |.|||  ||   ..|  
deislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..ercey

YWPSRGSLSYED----ITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRadppgagPMVVHCSAGVGRTGTF
|||   | |       . ..   | . .  . |   ..  | ||  .  .     .   .   |  ..|  .|. ..       |.||..  || ...|.
ywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgdvnnssdvysplrvlrklrnlsk.......pvvvqdilGvskaatl

IVIDVMLQQIHEEKT--VDILGFVSTLRRHRNLMVQTEQQYIFIHDALL
. |.. | ..    .    .|  |  ||..|.| |..  .|.|..  .|
vaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl

subfamily_PTPN12_pd Subfamily PTPN12 34-277 1.3e-79 262.2 In-house 30-277 (290) alignment
Range on Protein: 34-277
Range on HMM: 30-277/290.0
VTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYW
......  ..|..|||| .|. ||.|||.|.  |.|.|||||||||. |   . .||||||||..|  |||||.||.| . ..|. .. |  . ||..||
ysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYW

PSRG--SLSYEDITVTLDSVTELT-PYIVRTLSVQREgcDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADPPGAGPMVVHCSAGVGRTGTFIVI
|..|  .| .....|||..   ..  ...||| |...  .. |.|.|||.|.|||||||.|. .||.....  .     . |.||||||||||||| |.|
peegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiai

DVMLQQIHEEKT---VDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAI
| . .....||.   .|.   | .||..|. .|||..|| ... |... .
dyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv

subfamily_PTPN3_pd Subfamily PTPN3 34-276 4.9e-73 240.5 In-house 31-274 (280) alignment
Range on Protein: 34-276
Range on HMM: 31-274/280.0
VTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDepgsDYINANFL----PGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKC
.. ...  | | .|||| .|..||. ||||.. |     ||||||..    |.    | |||.|||||.|. |||.|||||.|..|.|||.| || | ||
laisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkC

AQYWPSRG-SLSYEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADPPGAGPMVVHCSAGVGRTGTFI
 ||||. . .|.| ...|.. .  | . |..| | ....  .. |.. |. ...|||||||..  ..| ||.   ..      |.|||||||.|||| .|
hqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvli

VIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDA
.... |. | ... | .|  |.|.|  |  .|||..|| |. .|.| .
lletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv

subfamily_PTPN1_pd Subfamily PTPN1 34-279 1.6e-66 218.9 In-house 22-273 (290) alignment
Range on Protein: 34-279
Range on HMM: 22-273/290.0
VTATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDepgsDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYW
...... .| |. .||| ..  |||||.||.. .     |||||...   . .  || .||||..|.  ||.|||||.|....|| .. |. . ||||||
fptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqyw

PSRGS---LSYEDIT--VTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFV---RDSTRAdPPGAGPMVVHCSAGVGRTG
|.  .   | .||..  |.| |  .   |.||.| ..   ... |.. .||.|.||| ||| |  ..| |.   |.|     .  || |.|||||.||.|
PqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGsl.ssdvGpavihcsaGiGrsG

TFIVIDVMLQQIHEEKT---VDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIIS
||...| .| .|....    |||   .  ||..|  ..|| .|  | . |.|. .  
tfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakv

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 34-277 5.5e-49 161.3 In-house 27-269 (281) alignment
Range on Protein: 34-277
Range on HMM: 27-269/281.0
VTATHSLDPVNQHKNRYINIVAYDHSRVKLQD-FEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQY
  .|   .|||..||||.|| . | |||.|.  . ..  .||| ||..        || .|||  ||  |||||.|..|. .|.|| .. |  |.|||.|
dlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaey

WPSR--GSLSYEDITVTLDSVTELTPYIVRTLSVQREGcdDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDsTRADppgAGPMVVHCSAGVGRTGTFIVI
.|      | .. ..|. .  |     .   | .  ||  . | . .. .  |||  || |   .|  .|   ||    . | |.||||||||.||.. .
fprnahcclqfdklsvsyedstvnkslvttrlnlsyeg..etrlithwlwkewpdwqvpessevmlkilrk.irar...stppvihcsagvgrsgtlmav

DVMLQQIHEEKTV-DILGFVSTLRR-HRNLMVQTEQQYIFIHDALLDAI
.. || ||   |. ||   || ||   |   ||| |||..|   |||  
eialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfg

DSPc_SM00195 35-277 7e-92 302.8 In-house 17-262 (263) alignment
Range on Protein: 35-277
Range on HMM: 17-262/263.0
TATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWP
. |..  . |..|||| ||. |||.||||.. |...||||||||.. |......|||.|||| .|..||||||||.....|.|||. .|... ||..|||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

SR--GSLSYEDITVTLDSVTELT-PYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVP---TSVCNLLAFVRDSTRADppgAGPMVVHCSAGVGRTGTFI
.   |.  ...|.|.| .|..    .|.|||... ||... |.|.|.....|||||||   .|| .|| .|. |..      ||.||||||||||||||.
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...sgpivVhCsaGvgRtgtfv

VIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAI
.||..|....|||.|||   |. || .|  ||||..||.||..|.|..|
tidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 35-277 7e-92 302.8 In-house 17-262 (263) alignment
Range on Protein: 35-277
Range on HMM: 17-262/263.0
TATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWP
. |..  . |..|||| ||. |||.||||.. |...||||||||.. |......|||.|||| .|..||||||||.....|.|||. .|... ||..|||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

SR--GSLSYEDITVTLDSVTELT-PYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVP---TSVCNLLAFVRDSTRADppgAGPMVVHCSAGVGRTGTFI
.   |.  ...|.|.| .|..    .|.|||... ||... |.|.|.....|||||||   .|| .|| .|. |..      ||.||||||||||||||.
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...sgpivVhCsaGvgRtgtfv

VIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAI
.||..|....|||.|||   |. || .|  ||||..||.||..|.|..|
tidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_PTPRN_pd Subfamily PTPRN 35-274 6.1e-59 194.1 In-house 47-289 (297) alignment
Range on Protein: 35-274
Range on HMM: 47-289/297.0
TATHSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPG-YRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYW
|.. . .. | .|||. ....||||||||..  ..  |||||| ..     |  ||||.|||||.|  |||.||||| .  |..||.|.|    .|..||
tkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckryw

PSRGSLSYEDITVTLDSVTE-LTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADPPGAGPMVVHCSAGVGRTGTFIVIDV
|  ||  |.   | | |       |.||.. ..    .. | | |||| |||..|||.|  .|| | |   ..    . |.|||||.|.||||..|.||.
pdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidl

MLQQIHE-EKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALL
.|...    | .||   .  ||  |. .|.|..|. |.  |. 
vlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltava

0040439 (Phosphotyrosine protein) phosphatases II 37-277 1.6e-88 291.8 In-house 4-246 (249) alignment
Range on Protein: 37-277
Range on HMM: 4-246/249.0
THSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSR
...| |.|..|||| .|..||||||||..... ..||||||....||.. ...||.|||| ||. |||||.||.....|.|||.|.|. | |||||||..
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplg

GSLSYEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTR--ADPPGAGPMVVHCSAGVGRTGTFIVIDVML
||| |.|.|||| ||...  |.|||| ... .....|.|.....|.||||||| |.  ||.|..      .. |  ||..||||||||||||||... ||
gsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylml

QQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAI
.|...|..||..  |..||..|. .||...||.|...|||. .
eqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 37-268 1.1e-31 104.8 In-house 43-272 (301) alignment
Range on Protein: 37-268
Range on HMM: 43-272/301.0
THSLDPVNQHKNRYINIVAYDHSRVKLQDfedEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSR
|.|.  ....|.|| ..    .. |.. .   .     | ||..|   . . .||.|||| .|. ||| |.   .  .|.||..  |.  .||..| |..
tesyaylpkdkhryptvPckPstaveviv...dGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvk

GS--LSYEDITVTLDSVTEL--TPYIVRTLSVQRE-GCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADPpgagPMVVHCSAGVGRTGTFIVID
 |  |  .  .... .   .     . ||| |.   |  . | |  . ...|.|.||| |  .|  ..    ...     |.|||||||.||. .||  .
isekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek....PivvhcsaGiGrsvafigte

VMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIF
.. .... ..|...   .  || ||   |||..|  .
ylareveadptieltealkhlrehrwngvqtnsqlyw

0042113 (Phosphotyrosine protein) phosphatases II 38-275 7.7e-88 289.3 In-house 3-241 (245) alignment
Range on Protein: 38-275
Range on HMM: 3-241/245.0
HSLDPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRG
..| |.|..|||| .|..|||.||||.. . ...||||||.. .|||. . .||.||||.||. |||||.||....||.|||.. |. | |||||||...
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplge

SLSYEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADP-PGAGPMVVHCSAGVGRTGTFIVIDVMLQQ
|| |.|.|||| |.. |  |.||||.|...|.| .|.| ..|...|||||||...  || |..   .|   .. ||..||||||||||||||... ||.|
sltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleq

IHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLD
...|..|..   |  ||..|  .|||..||.|...|||.
lekelgvsleeavkelrsqRpgavqtpsqyrflyealle

0037934 (Phosphotyrosine protein) phosphatases II 38-275 1.5e-79 262.2 In-house 4-240 (243) alignment
Range on Protein: 38-275
Range on HMM: 4-240/243.0
HSLDPVNQHKNRYINIVAYDHSRVKLqdfedePGSDYINANFLPGYRRdnaYIAAQGPLAETCRD----FWRMVWEQNSRTIIMLTNLKERCRDKCAQYW
..| |.|..|||| .|..||||||||      .||||||||. ....|   .|| |||| ||. |    ||||.||.....|.|||.|.|. | ||||||
iallpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PsrGSLSYEDITVTLDSVTELTPYIVRTLSVQREG-CDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRA--------DPPGAGPMVVHCSAGVGRT
|  |.  |.|.|||| |...|  |.||||.... .  | .|.| ..|...|||||||.|. .||.|... .            .. ||..||||||||||
p..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRt

GTFIVIDVMLQQIheekTVDILGFVSTLRRHRNL-MVQTEQQYIFIHDALLD
||.|....||...    .||..  | .||..|.  .|||..||.|...||| 
Gtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 40-281 5.9e-41 135.1 In-house 51-293 (305) alignment
Range on Protein: 40-281
Range on HMM: 51-293/305.0
LDPVNQHKNRYINIVAYDHSRVKLQDFEdepGSDYINANFLPG-YRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPS-RG
   ... |||| .. . |.| |||..      |||| ||..      .. .|.||||| .|  .|| || ...   |.|| .  |  . |||||||  .|
sadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqg

SLSYEDITVTLDSVTELTP-----YI-VRTLSVQREGcDDVRQVKQFHFTSWPDHGVPTSVC---NLLAFVRDStradppgAGPMVVHCSAGVGRTGTFI
        . .. |.   |      | . .| .   | |.   |.....| ||| |||       .||. .| |         |.|||||||.||||| .
eklelksgivvenvsgskpmerdaeiqitllnltysg.dqkmsvrhlqwtewpdrgvppckltslellsairgs.......kvpivvhcsagigrtgtiv

VIDVMLQQIHEEKTVD-ILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGE
 |. .|..| |.| .  .  .| .|| .|   .|.. ||.|||  .|. ..   
aieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfleky

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 41-279 9.8e-87 285.3 In-house 6-244 (250) alignment
Range on Protein: 41-279
Range on HMM: 6-244/250.0
DPVNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDkCAQYWPSRGSLS
.| |..|||| .|.|.|.||| |.  . .  |||||| || ||.  .|.||.|||| .|  ||||||.|..| ||.|||||||  .  . ||||  ..  
kpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaek

YEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADPP-GAGPMVVHCSAGVGRTGTFIVIDVMLQQIHE
| |.||.| |  | . |..|.| . ..   | |.|.|.||..||| |||      |.....  . ..  |..|..|.|||||||.|.||.|| .|.....
yGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkk

EKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIIS
||.||.  .. .||..|  .|....||.|.. ..| |. |
ekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 41-274 1.5e-61 202.7 In-house 35-274 (287) alignment
Range on Protein: 41-274
Range on HMM: 35-274/287.0
DPVNQHKNRYINIVAYDHSRVKLQdFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRG-SL
.  . .|||| ... .|..|| |   | | ||||||||....|..|.|.||||||.| | |||||.|.|..| ..|..|   | .| || .||| |   .
elaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPm

SYEDITVTLDSVTELTP-YIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDS-----TRADPPGAGPMVVHCSAGVGRTGTFIVIDVM
     .|.| . . . | | ||.| .      . | |||... ||||.... .   |. || |       . |  ..||.|||...|.||.|... . |.
rvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvl

LQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALL
...  .   ||.   |  || .|. .||.  |. .. .|| 
vsrledlGrvdvaavvirlreyraalvqavvqlrllyealv

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 41-279 6e-32 105.7 In-house 32-272 (285) alignment
Range on Protein: 41-279
Range on HMM: 32-272/285.0
DPVNQHKNRYINIVAYDHSRVKLQDFEdepgSDYINANFLPGYRR-DNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGS-
   |   ||| .. . . .|| |....     ||| |...    . ...||..|||| ||  |||.|.....   ..||  | |   .||| |.| .   
yeanpdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

-LSYEDITVTLD--SVTELTPYIVRTLSVQR--EGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADPpGAGPMVVHCSAGVGRTGTFIVIDVM
 . .    .||       ..  |. .|.|    . . .   ... .   |||.  |     .. . .   . .|    |..|||||||||| ||. ||  
vvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnp.kekpicvhcsagvgrtatfvgidya

LQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIIS
  .| |.  ...|  |  .|  |   ||.  |..|..  |.. .| 
tirimenpniemldivremramrfqavqshmqflflyvvlmeyfig

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 43-276 5.5e-75 246.6 In-house 6-239 (239) alignment
Range on Protein: 43-276
Range on HMM: 6-239/239.0
VNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRR-DNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGSlSY
||. |||| |||.|||||| |. . ..| ||||||..|  |    .||||.|| .. .. |||||.|..    |.||| | |  . || ||||   |  |
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.ky

EDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEK
 .. |||     .. ||.||. . . |  . | | |.||| |||.|||     .| . |  |.   ||| | |.||||||||||.|.||| ||.| ...|
cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqk

TVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDA
||||. .| ..|  |  |||| .||.||| |.|.|
tvdifnyvkairedrphmvqtseqyvfihlavlea

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 43-274 1.5e-74 245.2 In-house 7-238 (239) alignment
Range on Protein: 43-274
Range on HMM: 7-238/239.0
VNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRR-DNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGSlSY
||. |||| |||.|||||| |. . ..| ||||||..|  |    .||||.|| .. .. |||||.|..    |.||| | |  . || ||||   |  |
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.ky

EDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEK
 .. |||     .. ||.||. . . |  . | | |.||| |||.|||     .| . |  |.   ||| | |.||||||||||.|.||| ||.| ...|
cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqk

TVDILGFVSTLRRHRNLMVQTEQQYIFIHDALL
||||. .| ..|  |  |||| .||.||| |.|
tvdifnyvkairedrphmvqtseqyvfihlavl

subfamily_PTPN13_pd Subfamily PTPN13 43-276 1.1e-70 233.0 In-house 36-268 (273) alignment
Range on Protein: 43-276
Range on HMM: 36-268/273.0
VNQHKNRYINIVAYDHSRVKLQDfedEPGsdYINANFLPGYRRD--NAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGS--
 |..|||| |.. ||..||||.|   | |  ||||...     .    |||.|||| ||..|||.|||||... |.|.|. ||. . || .|||.. .  
enkdknryrnvlPydetrvklgd...egg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkk

LS-YEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADPpGAGPMVVHCSAGVGRTGTFIVIDVMLQQI
|  .. ..|.|  |..|  . ||.| |.     ..|.| ...|..|||||||.|  .|| ||.   | .   |||.|||||||.||.||.|.|||.|. |
lkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitidvvlgli

HEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDA
. .| .|.   | .||. |. .|||..||||.. |.|..
erdkefdvkeivrklreqrqgvvqtkdqyifvykailev

subfamily_PTPN23_pd Subfamily PTPN23 43-276 1.6e-63 209.3 In-house 42-279 (288) alignment
Range on Protein: 43-276
Range on HMM: 42-279/288.0
VNQHKNRYINIVAYDHSRVKLQDFEDepgsDYINANFLPGYRRD-NAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRG--SL
.. .|||. .|. |||.||||.. .|    ||||| |. .       .||.|.||..|  |||.||.|| |..|.||.. .|. . |...|||..   . 
lyseknrsrdilPyDhnRvklrgskD....DYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetv

SYEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTR----ADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQ
...|..||| ||.|. ... |.|... .. | |..|.  ..||||..||| |  .||.|.            .   |.||||||||||||.| ..   ..
kfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavr

QIHEEKT-VDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDA
......  .||.  ||.||. |  |||...|. |  .| | |
elekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 43-286 7.5e-45 148.2 In-house 40-286 (307) alignment
Range on Protein: 43-286
Range on HMM: 40-286/307.0
VNQHKNRYINIVAYDHSRVKLQdFeDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRG--SLS
 |..|||| .. . |..|. .. | |   |||| ||.|    . . .|.||||| .|  .|| |. ...  ..||| .. | .. || ||||      | 
antdknryqdvkcqdkgrivvk.f.dglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklv

YE----DITVTLDSVTELTPY--IVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVrDSTRADppgAGPMVVHCSAGVGRTGTFIVIDVML
.      |.|.   . .|.|   ..   ... . ... | .... .. |||.|||    . . .. ...| |     |.||||||||||.|| . | .. 
fgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainll.eavryd...tnpvvvhcsaGvGrsGtivaislvq

-QQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGETETSA
 . |  .   |.  .|  || .|.  .||| ||...|  ||.  .    || .
dkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyketye

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 43-289 1.8e-38 126.8 In-house 51-301 (310) alignment
Range on Protein: 43-289
Range on HMM: 51-301/310.0
VNQHKNRYINIVAYDHSRVKLQdFEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGSL-SY
 . ||||| ..|  | |||||.  .     ||| ||..      ...| .||||  |  |||||.... . .|..| .  |  | ||  |||| |   .|
kymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtety

EDITVTL--DSVTEL-----T-PYIVRTLSVQREGCD-DVRQVKQFHFTSWPDHGVPTSVCNLLAfvrDSTRADpPGAGPMVVHCSAGVGRTGTFIVIDV
  | ||   .|  |.     .  ..   . |. . .. .  .|.  ..  ||| |||   |  .    .   |.    || |||||||..|... . ...
gcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp...qrllaq.vrhgpcvvhcsagkdrlyvvvalkl

MLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLdAIISGETETSASDL
 ...... . ||.   .. |...|   .||| ||..|.   . ..  ||||.. . |
kidkldrglkvdaeevktellksraiciqtelqyliidrvri.ifargetevaekil

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 43-194 2.7e-12 39.9 In-house 26-160 (169) alignment
Range on Protein: 43-194
Range on HMM: 26-160/169.0
VNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINAnflpgyrrdnayiaaqgplaetcrdfwRMVWEQNSRTIIMLTNLKERCR----DKCAQYWPS--R
.|. |||    .|  | |||||   .. |||||||                           ||.|| |.  |..| .  ..       .  |  |.   
cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddknnfwpekedyqlhpavil

GSLSYEDITVTLDSVTELTPY---IVRTLSVQREGCDDVR-QVKQFHFTSWPDHGVPTSVCN
|    . . |  | |. .|     ..    |  .  |||  ... .|...||. ||| |  .
gewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqspvh

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 43-194 1.7e-11 37.2 In-house 25-159 (169) alignment
Range on Protein: 43-194
Range on HMM: 25-159/169.0
VNQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINAnflpgyrrdnayiaaqgplaetcrdfwRMVWEQNSRTIIMLTNLKERCR----DKCAQYWPS--R
.|. |||    .|  | |||||   .. |||||||                           ||.|| |.  |..| .  ..       .  |  |.   
cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddknnfwpekedyqlhpavil

GSLSYEDITVTLDSVTELTPYI---VRTLSVQREGCDDVRQ-VKQFHFTSWPDHGVPTSVCN
|    . . |  | |.  |  .   .    |  .  ||| . .. .|...||. ||| |  .
Gewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspvh

Y_phosphatase Protein-tyrosine phosphatase 44-274 1.7e-88 291.4 Pfam-A 1-234 (235) alignment
Range on Protein: 44-274
Range on HMM: 1-234/235.0
NQHKNRYINIVAYDHSRVKLqdfEDEPG-SDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWP--SRGSLS
|..|||| .|..||..||||   ....| |||||||.. ||......||.|||| .|. |||||||......|.|||.|.|. | |||||||  ...||.
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YEDITVTLD-SVT-ELTPYIVRTLSVQREGCDD-VRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQI
|.||.|.|  ... . . |..|.|... .. ..  |.|||.|.|.|||||||.|. .|| ..|.  .   .  ||.||||||||||||||...|..|.|.
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

HEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALL
..|..||.| .|..||..|. |||...||||...|.|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 44-274 1.7e-88 291.4 In-house 1-234 (235) alignment
Range on Protein: 44-274
Range on HMM: 1-234/235.0
NQHKNRYINIVAYDHSRVKLqdfEDEPG-SDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWP--SRGSLS
|..|||| .|..||..||||   ....| |||||||.. ||......||.|||| .|. |||||||......|.|||.|.|. | |||||||  ...||.
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YEDITVTLD-SVT-ELTPYIVRTLSVQREGCDD-VRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQI
|.||.|.|  ... . . |..|.|... .. ..  |.|||.|.|.|||||||.|. .|| ..|.  .   .  ||.||||||||||||||...|..|.|.
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

HEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALL
..|..||.| .|..||..|. |||...||||...|.|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 44-274 6.1e-70 230.1 In-house 3-236 (237) alignment
Range on Protein: 44-274
Range on HMM: 3-236/237.0
NQHKNRYINIVAYDHSRVKLQDFEDEpgSDYINANFLPGYRR-DNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRG-SLSY
|. |||| |||||||||| |.    .  ||||||..| |.    . ||||||||  .| |||.|||...   |.||| | |. . || .||||     .|
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

EDITVTLDSVTELTPYIVRTLSVQR-EGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADP--PGAGPMVVHCSAGVGRTGTFIVIDVMLQQIH
  .||.|    |.. | ||.| ...     .|| ..|..||||||.|||   . || | ..     |  . .|| ..|||||||||| |.||| ||.| .
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

EEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALL
|.| |||  .| ..   |  ..||..||.|||...|
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtil

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 44-274 4.8e-68 224.1 In-house 20-261 (270) alignment
Range on Protein: 44-274
Range on HMM: 20-261/270.0
NQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYR-RDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRG----S
... ||| .|.   ..||.|.. |... . |||||...|.  ....||||.|||. | ..||||.||.....|.|.|.|.|. |.||..|||..     .
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

LSYEDITVTLDSVTELTPYIVRTLSVQREGcdDVRQVKQFHFTSWPDHGVPTSVC------NLLAFVRDS--TRADPPGAGPMVVHCSAGVGRTGTFIVI
|.. .|.|.  | .  . ||.. | ....|  . |..  |....|||||||..        .||. .|.   .. .   |.|..||||||||||||.|..
ledgkikvlalseekeegyiltrlrleekg..eerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlial

DVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALL
| ... ..|.| ||.|  .. ||..|  .||. .|| |.. |..
DiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavv

0041856 (Phosphotyrosine protein) phosphatases II 44-281 4.4e-55 181.4 In-house 1-175 (182) alignment
Range on Protein: 44-281
Range on HMM: 1-175/182.0
NQHKNRYINIVAYDHSRvklqdfedepGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTnlkercrdkCAQYWPSRGslsyed
|..|||| .|. |||||          ..||||||.. |..... .||.|||| .|. ||.||..|.. .||..||         . .|||..       
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

itvtldsvteltpyivrtlsvqregcddVRQVKQFHFTSWPDHGVPTsVCNLLAFVRDSTRadppGAGPMVVHCSAGVGRTGTFIVIDVMLQQiheekTV
                             |.. |.....|||||||. .  ||.|...  .      || .||||||||||||......|...      |
............................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gv

DILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIISGE
..   |...|..|. ||.|..||.|...|||. .  ..
sleeavklvrsrRpgmvitpnqyfflqlallellllkk

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 44-276 5.3e-45 148.4 In-house 48-286 (305) alignment
Range on Protein: 44-276
Range on HMM: 48-286/305.0
NQHKNRYINIVAYDHSRVKLqdfEDEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRG--SLSY
...|||| ..   |. ||||   |     .|| ||..      . .| .| || .|| ||| | ....  .|.|| ||.|.   ||..|..|.    |..
eagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlef

E----DITVTLDSVTEL------TPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDStRadpPGAGPMVVHCSAGVGRTGTFIVID
|     |.| ..| ..|         . .|  |      ..|.|...|.  ||| |||..   .| .. .. |   |  ||.|||||||.||||. ....
eekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka.r...pskgpivvhcsagigrtgsvvmle

VMLQQIHEEKTVDI-LGFVSTLRRHRNLMVQTEQQYIFIHDALLDA
 .|.|. . . ..     .  .|  ||  .||..||.|.|. .|. 
yildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilny

subfamily_ptpA1_pd Subfamily ptpA1 44-238 7.1e-39 128.7 In-house 47-257 (418) alignment
Range on Protein: 44-238
Range on HMM: 47-257/418.0
NQHKNRYINIVAYDHSRVKLQDFEDEPGSDYINANFLPGYRrDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSR-------
|  |||| ||.  .|.||.|.  .|. ||||||||.. |    . .|..|||| .|  ||||||||.  | |.||.   | || || .||| .       
ntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfs

----GSLSYEDITVTLDSVTELT--PYIVRTLSVQREGcdDVRQVKQFHFTSWPDHGVPTSVCN---LLAFVRDSTRADPP---GAGPMVVHCSAGVGRT
    |   .   .| |  | .      | | . .  ||  . |.. |...  |||| .|        ||  . .      |      |..||||||||||
iygngnevfgtysvelveviqdpereiitrnirltfeg..etrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrt

GTFIVIDVMLQQIH
|||    .|.... 
gtfctavimmkkld

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 44-278 2.3e-38 126.9 In-house 43-272 (288) alignment
Range on Protein: 44-278
Range on HMM: 43-272/288.0
NQHKNRYINIVAYDHSRVKLQdfeDEPgSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGSLS---
|  ..|| |.   | .||||.   |.|   ||.|| ..  . ..  | || ||  |   .|.|. |.. . |.||..| |. ..| |.|.||.   .   
nptrdryenlprcditrvkls...ddp.dfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

YEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVrdsTRAdPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEE
    ||. .. ...   .. .|    .  ..   ||. |.  |.|.||| .    | ..   ..       |.|||.|||||||||.|.| ..|...  .
grlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrll...evl.kslqkPivvhssaGvGrtgtlililialeslrld

KTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAII
  . |  ... || .|   .|||.||...|  .|. ..
dflgirsllaklreerfkaiqtemqylyvhrcvleell

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 44-198 2.1e-37 123.6 In-house 33-189 (297) alignment
Range on Protein: 44-198
Range on HMM: 33-189/297.0
NQHKNRYINIVAYDHSRVKLQDfeDEPGSDYINANFL--PGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSR--GSL
  .|||| .|.|.| .||||.     ...|||||...  |    |  || ||||| .|  |||..|.||. |.|.|...|.|  ||||| ||||   . |
slrknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerl

SYEDITVTLDSVTE--LTPYIVRTLSVQREgcDDVRQVKQFHFTSWPDHGVPTSVCNLLAF
   |. |   | |       |.  | .     .. |.|.   | ||||||||. . .|  |
kagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrf

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 44-274 1e-20 68.4 In-house 51-282 (302) alignment
Range on Protein: 44-274
Range on HMM: 51-282/302.0
NQHKNRYINIVAYDHSRVKLQDFEDepgsDYINANFL--PGYRrdNAYIAAQGPLAETC---RDFWRMVWEQNSRTIIMLTNlKERCRDKCAQYWP--SR
| .||.  .. ..|. .|||.  .|    .|.||  .  |  .  .  | || |  ..     .|||||....  .. .|   .| .     ...|  | 
nlkknqsedvpildsnlvkleaepd....syvnaskvevPelt..rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvg.eeelkktlselfpkksg

GSLSYEDITVTLDSVTELTPYI-VRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQ
  . |... |    | .        .. |  ||| .   ..  ..| |... ||... .| . . .    . ..  ..|.    |.|| |.|..  | ..
dykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavave

QIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALL
.....| . |   | ..|  |  .|.. .||.... |||
klqkgkepnikeivksiRsqRpravdslkQyvslyiall

subfamily_eak_pd Subfamily eak 44-197 1e-13 45.4 In-house 52-202 (332) alignment
Range on Protein: 44-197
Range on HMM: 52-202/332.0
NQHKNrYINIVAYDHSRVKLQDFEDEPgSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRG--SLSY
. ..|  ..|| ||.  |.|     ..   ||||  .      . || .  .  .    ||.|| ||.| .|..| .  |   .|  .|.| ..   |..
avnrn.vvkivpydrylvrltssqlnr.lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkf

EDITVTLDSVTELTPYIVRTLSVQReGcDDVRQVKQFHFTSWPDHGVPTsVCNLLA
  . |.  .  .   . .| | ... | ..  .|. ...  | .  .|  . ..||
Gildverkefvkrniletrllelsk.G.nethrvlhykvfGwtettlpk.yedfla

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 44-130 8.6e-12 39.2 In-house 34-119 (332) alignment
Range on Protein: 44-130
Range on HMM: 34-119/332.0
NQHKNRYINIVAYDHSRVKLQDFEdePGSDYINANFLPGYRRDNAYIAAQGPLAE-TCRDFWRMVWEQNSRTIIMLTNLKERCRDKCA
|   ||   . ..|||||.|   .     |. ||... || . .||| || |. . |   ||||| |..   |... .. |. . |. 
nmdmnriphlycfdhsrvelapqd..gkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkap

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 45-275 2.1e-50 166.0 In-house 57-281 (290) alignment
Range on Protein: 45-275
Range on HMM: 57-281/290.0
QHKNRYINIVAYDHSRVKLQDFEDepgSDYINANFLPGYRrdNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRG--SLSYE
 .|||| ..|  | .|| |.|  |    ||. ||.. | .    .| .||.|..|  |.|||| ...  .|.|| .| |  . ||.||.| .    |.. 
fkknrykdvvcndktrvilkdGyd...GdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfG

DITVTLDSVT-ELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRAdppgAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEK
.|||.    . . .  | .||||.        ..| ..  ||||. |. |   ||  .|   .|    .||.|||||||.||||||. |.| || . . |
eitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka....sGpvvvhcsaGiGrtGtfvaievglqilldGk

TVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLD
 .|.|. | .||. |   || . ||. . ..|||
eldlldlvralrnsrlnsvqvdiqylalveilld

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 46-153 2.7e-25 83.8 In-house 49-167 (350) alignment
Range on Protein: 46-153
Range on HMM: 49-167/350.0
HKNRYINIVAYDHSRVKLQDF--------EDEPGSDYINANFLPG----YRRDN--AYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQ
 |||| ||. |.||||||.              ..||||||.|       . .    |||.|.|| .|  ||.... . . . |..||.. |  ..|| .
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPSrgsLSYEDITVTLDSVTE
||.    .||.|||| | |  |
YWqe...gsydditvklaskwe

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 46-153 2.5e-16 53.9 In-house 50-170 (349) alignment
Range on Protein: 46-153
Range on HMM: 50-170/349.0
HKNRYINIVAYDHSRVKLQDFEDEPG--------------SDYINANFL--PGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKC
 |||| .|. |.||||||.     .                ||||||.|  . .  .. ||| | ||  |  ||....  .. . .. |.. ||   .||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

AQYWPsrgSLSYEDITVTLDSVTE
 .||     |||..||| |    .
diywq...elsysnitvklqnssl

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 46-117 4.2e-07 23.8 In-house 39-115 (347) alignment
Range on Protein: 46-117
Range on HMM: 39-115/347.0
HKNRYINIVAYDHSRVKLQDFE-----DEPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIM
 |||  .    | .|| |   .      ..   ||||  .     .. || .| || .| ||||.||   .   .. 
sknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 47-279 7.2e-32 105.3 In-house 46-278 (312) alignment
Range on Protein: 47-279
Range on HMM: 46-278/312.0
KNRYINIVAYDHSRVKLQDFEdepgSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPS-RGSLSYEDIT
 ||| ||  .|  |  |   |      || |||.    . . ....|||| .||  ||...    | .||.|. . |   .|||.|     | .  ||  
lnrypniqcwdrgrftlagde....nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhr

VTLDSVTELT-------PYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSvCNLLAFVRDSTRADppgAGPMVVHCSAGVGRTGTFIVIDVMLQQIH
|  ...||.            | | |      .  ..... ..||||||.| | |.    .  . . |     |.. |||||||||||...|. |.  . 
vyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpds.cdtalrllsavkkd...kkpviahcsagvgrtgtlaliesmiaalr

EEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIIS
  .  ..      ||. |   |..  ||..   ..|. . |
hprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflys

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 47-278 6.3e-23 76.3 In-house 22-260 (290) alignment
Range on Protein: 47-278
Range on HMM: 22-260/290.0
KNRYiNIVAYDHSRVKLQDFEDEPGSDYINANFLpGYRRDNAYIAAQGPLAET-------CRDFWRMVWEQNSRTIIMLTNLKERCRD----KCAQYWPS
..|. ..    ..|| |...     .||| ||..  .  . . |. | |....         .|| |. . ... ..|| . .|....     ||.| | 
dqRl.evpLveatrvvLkgygkrfnddyiHAnrv.tcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpe

R--GSLSYEDITVTLDSVTELTPYIVRTLSVQREGCDDVrQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRAdppgAGPMVVHCSAGVGRTGTFIVIDVM
.  ..| ....||   |  .    ..|.| |. ..  .  .|.   . .| .  |. .   ||. ..           |..|||  |. |  ..  |.. 
svgeelkfkgltvkCkskekeddvetRelvvkfddeeef.tvtHsllkgWnklnvqedtktllsliqkvkas....ktpvivHcvdGiSrsAalaaiilg

LQQIH-EEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAII
 | |   .. | .   ...||..|.|........ |.  ...  .|
yQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllai

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 55-188 3.3e-12 40.9 In-house 4-126 (130) alignment
Range on Protein: 55-188
Range on HMM: 4-126/130.0
AYDHSRVKlqdfedepGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERcrdkcAQYWPSRGSLS-Y-EDITVTLDSVT
 .. ||..        | .||||.|.    | . |. .| |||.|. |||.|. |.    ...|  ..|       .|||    |  | |||.|||    
efevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdrd

ELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGV
|        | ....  .  . .  |. . ||  | 
efknikasnleiesdlneshqaltmfqisnwpsdgt

0044763 (Phosphotyrosine protein) phosphatases II 56-272 7.1e-39 128.6 In-house 2-166 (178) alignment
Range on Protein: 56-272
Range on HMM: 2-166/178.0
YDHSRVKLQDFEDEPGSDYINANFLPGYrrdnAYIAAQGPlaetcRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGSlsyeditvtldsvtelt
.|..||.|. .|....||||||..  ..     |.....|      |......|.. ..|..||. .|. . || .|||.. .                 
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

pyivrtlsvqregcddvrqvKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQiheekTVDILGFVSTLRRH
                     |.... .||||||..   .|.||.   .| ..  || .|||||||||.||..... |...      ...   .. .|..
....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrer

RNlMVQTEQQYIFIHDA
|. .|... |. .... 
Rp.ivpnpgqlrqLyef

0046846 (Phosphotyrosine protein) phosphatases II 67-273 8.5e-46 151.2 In-house 7-169 (176) alignment
Range on Protein: 67-273
Range on HMM: 7-169/176.0
EDEPGSDYINANFLPGYRrdnaYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSRGSLSYeditvtldsvteltpyivrtlsvqr
 .....||||||.. |.|    .|| |||| .|. ||..|..|.. .....||...|  | ||..|||   .|..                         
gldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.........................

egcddvrqvkQFHFTSWPDHGVPTSvCNLLAFVRDSTRADPPGaGPMVVHCSAGVGRTGTFIVIDVMLQqiheEKTVDILGFVSTLRRHRN-LMVQTEQQ
          |.... |||||||..   || ...   .|   | || .||||||.|||||..... .      || ....  ....|..|   .|||..|
..........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpeQ

YIFIHDAL
| |.....
yrflyefe

0043147 (Phosphotyrosine protein) phosphatases II 69-270 6.5e-46 151.5 In-house 2-154 (172) alignment
Range on Protein: 69-270
Range on HMM: 2-154/172.0
EPGSDYINANFLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLkercrdkcaqywpsrgslsyeditvtldsvteltpyivrtlsvQREG
..|||||||..|..|.  . .|| |||| .|. |||||..|.. ..|..||.|                                           .  .
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydp

CDDVRQVKQFHFTSWPDHGVPtSVCNLLAFVRDSTR--ADPPGaGPMVVHCSAGVGRTGTFIVIDVMLqqiheeKTVDILGFVSTLRRHRNLMVQTEQQY
 . .|.. |.....||||||| .   || |..   .  |  || ||..||||||||||||..... ||      . ....  |...|..|. .||...||
ellerlgiqylylpwpDhgvp.llellleflefidellalspg.gpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqy

IFIH
.|..
rfly

0051429 (Phosphotyrosine protein) phosphatases II 70-297 1.2e-59 197.4 In-house 2-244 (272) alignment
Range on Protein: 70-297
Range on HMM: 2-244/272.0
PGSDYINANFLPGYRR---DNAYIAAQGPLAETCRDFWRMvWEQNSRTIIMLTNLKERCRDKCAQYWP------------SRGSLSYEDITVTLDSVTEL
| |.||||....|| |   ........|||  |..||||. .|.. .||..|... || |.|| .|||            |  . .| ...||| |.. |
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

TPYIVRTLSVQRE-GCDDVRQVKQFHFTSWPDHGVP-TSVCNLLAFVRDstradppgAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVD--------
. ||.|.| . .. . ...|.| ..|.|.|||||||  ....||....|         ||..||||||..||||..... .|.....|  ||        
ldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

ILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAiISGETETSASDLRSHIRRLQ
....|. ||..|  .||||.||.|...|||.. . . ....|. |..... ..
leeaveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaaldaid

0036282 (Phosphotyrosine protein) phosphatases II 71-271 7.9e-51 167.5 In-house 1-164 (174) alignment
Range on Protein: 71-271
Range on HMM: 1-164/174.0
GSDYINANFLPGYRRDNAYIAAQGPLAetcrdFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSrgslsyeditvtldsvteltpyivrtlsvqrEGCD
|||||||..| .... . .|| |||||     ||.|..|....|..||...||. . || .|||.                                  |
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lred

DVRQVKQFHFTSWPDHGVPTSVCnLLAFVRDSTRADPP-GAGPMVVHCSAGVGRTGTFIVIDVMLQQIHeEKTVDILGFVSTLRRHRNLMVQTEQQYIFI
 .| . |.... |||||||..   || ||.   .|    . ||..||||||||||||..... ||.... |..||.| .| .||..|  ||||..||.|.
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

HD
..
yy

0051082 (Phosphotyrosine protein) phosphatases II 71-273 4.1e-38 125.6 In-house 2-149 (151) alignment
Range on Protein: 71-273
Range on HMM: 2-149/151.0
GSDYINANFLPGYrrdnaYIAAQGPLAetcrDFWRMVWEQNSRTIIMLTNLKERCrdKCAQYWPSRGslsyeditvtldsvteltpyivrtlsvqregcd
 |||||.... |.     ... .||||    ||.....|.. .||..|....||   .|..|.|. |                                 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

dvRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRadpPGAGPMVVHCSAGVGRTGTFIVIDVMLQQiheektVDILGFVSTLRRHRNLMVQTEQQYIFIH
  ..|.......|||.|.|.|   .|.|..   .   .. ||..||||||.|||||..... ||..      |..   .. .|..|  .||..||..|..
..ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

DAL
 ||
fal

0049260 (Phosphotyrosine protein) phosphatases II 79-271 1e-43 144.0 In-house 1-144 (152) alignment
Range on Protein: 79-271
Range on HMM: 1-144/152.0
FLPGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWpsrgslsyeditvtldsvteltpyivrtlsvqregcddvrqvkQF
|..||.. ...||.|||. .|. |||||..|.. .||.|||.| |. ..||.||.                                           |.
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

HFTSWPDHGVPTSVCNLLAFVRDSTRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLqqiheeKTVDILGFVSTLRRHRNLMVQTEQQYIFIHD
... |||||||..   || ...   ..     || .||||||||||||..... ||      . |... .|. .|..|. .|....|..|...
lhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 81-174 2.3e-13 44.3 In-house 230-322 (440) alignment
Range on Protein: 81-174
Range on HMM: 230-322/440.0
PGYRRDNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCrdkCAQYWPSR-GSLSYEDITVTLDSVTELTPYIVRTLSVQ-REGCDDVRQ
 || . ||.||.| ||  |  ||||.| . .  ||||| .|...    |. |||    |...  .||      ..    |||| .. .|   ..||
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndkt...csiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevheirq

subfamily_hpo-7_pd Subfamily hpo-7 85-286 8.6e-19 62.4 In-house 36-236 (263) alignment
Range on Protein: 85-286
Range on HMM: 36-236/263.0
RDNAYIAaqgpLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSR--GSLSYEDITVTLDSVTEltPYIVRTLSVQR--EGCDDVRQVKQFHF
| | |.     | .|   |....  ... ...||.. .|  ..|| .|.|    . . .....|.   | .    ...|| .    .    ...||.. .
rknlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysy

TSWPDHGVPTS---VCNLLAFVRDStRadppgagPMVVHCSAGVGRTGTFIVIDVMLQ----QIHEEKTVDI--LGFVSTLRRHRNLMVQTEQQYIFIHD
. |...  |.    . |.|  .|.| .       ..|||||.|.||.  | |.... |    .... .||..  | ..  || .|.  ..|  |  |   
kgWiekndpelareilnilkvarns.k.......slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsil

ALLDAIISGETETSA
 .|| ..   ..  .
mvLdfvlnnfakgel

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 86-270 3.6e-25 83.3 In-house 4-197 (199) alignment
Range on Protein: 86-270
Range on HMM: 4-197/199.0
DNAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSR--GSLSYEDITVTLDSVTELTPYIVRTLSVQRE--GCDDVRQVKQFHFT
.  |||.| || ||  |||.||||  |  |.|. . .       . |||.   |.  |  ..||  ..|    | . .| .  .       |.. .. ||
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWPDHGVPTsVCNLLAFVRD----STRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKT--VDILGFVSTLRRHRNLMVQTEQQYIFIH
|| ..  |  |. .. ||      | . .     |..|||| | | || |. .|. ..   | ||  ||..     ||. |  .. . |.| ||.
swkekttpn.valfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 86-291 1.2e-20 68.6 In-house 34-236 (255) alignment
Range on Protein: 86-291
Range on HMM: 34-236/255.0
DNAYIAaqgplaeTCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSR--GSLSYEDITVTLDSvtELTPYIVRTLSVQREGC--DDVRQVKQFHFT
 | |.        |   |....  ... ...||....|  ..|| .|.|    . | ..|..||       .  ..||| .  .       ..|| ....
knlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysyk

SWPDHGVPTSVCNLL---AFVRDStRadppgagPMVVHCSAGVGRTGTFIVIDVMLQ----QIHEEKTVDI--LGFVSTLRRHRNLMVQTEQQYIFIHDA
 |...  |    ..|     |||| .       ..|||||.|.||. .|...... |    .... .||..  | ..  || .|.  ..|  |  |    
GWieknaPelareilnilkvvrds.k.......svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilm

LLDAI-ISGETETSASDLRS
.|| .   || |   ...| 
vldlvfpkgeleakyqeirk

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 87-270 4.1e-25 83.1 In-house 4-196 (198) alignment
Range on Protein: 87-270
Range on HMM: 4-196/198.0
NAYIAAQGPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSR--GSLSYEDITVTLDSVTELTPYIVRTLSVQRE--GCDDVRQVKQFHFTS
  |||.| || ||  |||.||||  |  |.|. . .       . |||.   |.  |  ..||  ..|    | . .| .  .       |.. .. |||
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPTsVCNLLAFVRD----STRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKT--VDILGFVSTLRRHRNLMVQTEQQYIFIH
| ..  |  |. .. ||      | . .     |..|||| | | || |. .|. ..   | ||  ||..     ||. |  .. . |.| ||.
wkekttpn.valfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 94-270 2.5e-22 73.7 In-house 98-281 (302) alignment
Range on Protein: 94-270
Range on HMM: 98-281/302.0
GPLAETCRDFWRMVWEQNSRTIIMLTNLKERCRDKCAQYWPSR--GSLSYE-------DITVTLDSVTELTPYIVRTLSVQREGCD--DVRQVKQFHFTS
 |  .|.  .| .. . |   .. |....|    |||.|.  .  | | .        ..   |.  |.   . . |. .. |       . |. ..|..
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDHGVPTSVCNLLAFVRDSTRADppgaGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIH
||||| |    . |  ..            ..||||||||||||.. |   .|   ..|. |.|  |  .|. |   ||.||| |.. 
wpdhGapkeaytaldilkfcesyk....knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyll

0048076 (Phosphotyrosine protein) phosphatases II 132-273 2.1e-27 90.9 In-house 2-139 (145) alignment
Range on Protein: 132-273
Range on HMM: 2-139/145.0
YWPSR--GSLSYEDITVTLDSVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADPPGaGPMVVHCSAGVGRTGTFIV
||||.  ..| . .....||  .     | . |.. .|  . .|.. |.....|||||||..   ||.|..   .| . | ||..||||||||||||...
ywpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlva

IDVMLQqiheeKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDAL
...||.     . |..   .  .|..|  .|....|..|.....
aylmll.....lgvsleealelvrsqrpgavpnpgqlrflyefe

PTEN_1 148-229 1.9e-07 26.1 In-house 60-149 (196) alignment
Range on Protein: 148-229
Range on HMM: 60-149/196.0
LDSVTELTPYIVRTLSVQREG----CDDV----RQVKQFHFtSWPDHGVPTSVCNL--LAFVRDSTRADPPgAGPMVVHCSAGVGRTGTFIV
||.  |   . | .||  .|     .|.     ..|.. || ...|||.|.  . .  .. . .. ..||.  .  .||| ||.||.|| . 
ldnlkedgitlvvnlseeeelsgrsydleeffksgveylhf.pieDhgapslselfdicksfiewllsdpn.gnvVlVHCkaGlgRsGtvva

0048179 (Phosphotyrosine protein) phosphatases II 150-271 1.8e-26 88.0 In-house 24-139 (144) alignment
Range on Protein: 150-271
Range on HMM: 24-139/144.0
SVTELTPYIVRTLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADPPGaGPMVVHCSAGVGRTGTFIVIDVMLqqiheEKTVDILGFV
   .|  . | .|. ..|  .  |.. |.....|||||||..   ||.|..   .| ..| ||..||||||||||||......|.     .. ...   .
llkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk.....klglsleeal

STLRRHRNLMVQTEQQYIFIHD
  .|..|  .|....|..|...
alvrsrrpgavpnpgqlrfLle

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 161-259 1.2e-08 28.9 In-house 215-320 (347) alignment
Range on Protein: 161-259
Range on HMM: 215-320/347.0
TLSVQREGCDDVRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADPPG-------AGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLR
|. |  ||| .    | .  |.|| .  |  . ..||.||   .   .          |.|| |  |. |. | ..  ....|. . || |   .   .|
tvevvaegcseatfakvyncttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiiieqvldgktpdcddlfkkmr

RHRNLM
  |  .
dqragv

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 169-274 2.8e-15 50.9 In-house 212-341 (350) alignment
Range on Protein: 169-274
Range on HMM: 212-341/350.0
CDDVRqVKQFHFTSWPDH---GVPTSVCNLLA---FVRDS----TRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQ------QIHE--------EKTVD
.|    | |...  |.|      | |. . |     . |.    .  |   . |..||||||||||||.. .| .|.      .. .         || |
sdPyv.vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrD

I-LGFVSTLRRHRNLMVQTEQQYIFIHDALL
.    |  ||. |  |||. .|.|||..|||
lisiivnelrkqrismvqnldqfifiYeall

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 172-317 2.7e-30 100.1 In-house 88-234 (440) alignment
Range on Protein: 172-317
Range on HMM: 88-234/440.0
VRQVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRA-DPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIH
 | .||.|. .|||.|||  .  .| ...|   . .  | ||..||||||.||||  |..| .|.. .    .||. |....|  |  |||| .|| |.|
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

DALLDAIISGETETSASDLRSHIRRLQEQDPESGYTPMFTEFQKLSR
.|.|.....|.|     |.  .. ..|  .| .  .|.  ||.  |.
eavlegllcgdtliledditerveqiqwpnphtdksplqqefegysk

PTPc_DSPc_SM00012 174-274 3e-36 119.2 In-house 1-104 (105) alignment
Range on Protein: 174-274
Range on HMM: 1-104/105.0
QVKQFHFTSWPDHGVPTSVCNLLAFVRDSTRADP---PgAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEE-KTVDILGFVSTLRRHRNLMVQTEQQYIFI
.||..|.|.|||||||... ..| ..|.  .        ..|.||||||||||||||...|..|||...| |.|||. .|. ||..|. |||||.||.|.
tvkhyhytgwpdhgvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfl

HDALL
..|||
yrall

subfamily_PTPDC1_pd Subfamily PTPDC1 177-271 1.2e-07 26.3 In-house 84-170 (182) alignment
Range on Protein: 177-271
Range on HMM: 84-170/182.0
QFHFTSWPDHGVPtSVCNLLAFVRDSTRADPPGagPMVVHCSAGVGRTGTFIVIDVMLQQ-IHEEKTvdilgfVSTLRRHRNLMVQTEQQYIFIHD
 ..  .|.|.||. |. ..|  |.  . |   |   . ||| || ||||  |   .. .. .  ||.      ....| .|   .|| .|  ....
yvynfgwkDygva.sleriLdivkvvafalqeg..kvavhChaGlGrtGvliacylvyakrltaeka......iklvrskrpksiqtreqvelvke

0038934 (Phosphotyrosine protein) phosphatases II 178-271 5.8e-09 31.4 In-house 82-174 (194) alignment
Range on Protein: 178-271
Range on HMM: 82-174/194.0
FHFTSWPDHGVPT---SVCNLLAFVRDSTRADPPGagPMVVHCSAGVGRTGTFIVIDVMLQqiHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHD
..   .||.|..     ... | .| . ...||.|    .||| ||.|||||...   .    .  .  . .....  |..    ..  ...   ..
ylklpfpddgtvPsleillrfldlvdeflnedpgg..vvaVHCkaGlgRtGtlvaaYLiyr..lgmsaeeAialfrekRpgaipnqdyleallkryk

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 201-276 5.4e-16 53.3 In-house 219-294 (297) alignment
Range on Protein: 201-276
Range on HMM: 219-294/297.0
DSTRADPPGAGPMVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDA
.| ||. |   ...|||||||||.|  .  ||.|...  ..  |.  ..| ||  |  .||| .|. ...|| |  
eslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkk

subfamily_eak_pd Subfamily eak 206-279 1.5e-09 31.7 In-house 233-307 (332) alignment
Range on Protein: 206-279
Range on HMM: 233-307/332.0
DPPGAGPmVVHCSAGVGRTGTFIVIDVMLQQIHEEKT--VDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIIS
 ||   | .. .. |  |.|.|.|||.... | . |.    .  ..   . .|.  | ...|. ||....|| .  
tppsfap.iiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllr

subfamily_CG42327_pd Subfamily CG42327 210-272 1.1e-17 58.7 In-house 247-310 (319) alignment
Range on Protein: 210-272
Range on HMM: 247-310/319.0
AGPMVVHCSAGVGRTGTFIVIDVMLQQIHEE-KTVDILGFVSTLRRHRNLMVQTEQQYIFIHDA
 ||.||||| ||||||. |  |. .... |  ..|||   || .|| |   |.| .|| ||.  
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv

subfamily_CDC14_pd Subfamily CDC14 210-268 3.3e-06 21.2 In-house 263-317 (328) alignment
Range on Protein: 210-268
Range on HMM: 263-317/328.0
AGPMVVHCSAGVGRTGTFIVIDVMLQqiHEEKTVDILGFVSTLRrhrNLMVQT-EQQYIF
 | ..||| ||.|||||.|   .| .  ..  . ......   |     .| .  |... 
eGaiavhCkaGLGrtGtLiacylmkh..yrftaaeaiawlricr...PGsvigpqqkfle

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 211-275 4.2e-10 33.5 In-house 266-342 (349) alignment
Range on Protein: 211-275
Range on HMM: 266-342/349.0
GPMVVHCSAGVGRTGTFIVIDVMLQ-----QIH------EEKTVDIL-GFVSTLRRHRNLMVQTEQQYIFIHDALLD
 ...|||||| ||||... .|..|.     | .      . .. |..   | .||. |  |||  .|.|.|..||| 
stllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 213-278 1.1e-22 74.2 In-house 1-66 (69) alignment
Range on Protein: 213-278
Range on HMM: 1-66/69.0
MVVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAII
||||||.| ||||||| | | . .|  || |||.  |  .|. | .||  |..|||||||| .|. 
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealk

subfamily_PTEN_pd Subfamily PTEN 213-267 5.3e-06 21.5 In-house 117-170 (184) alignment
Range on Protein: 213-267
Range on HMM: 117-170/184.0
MVVHCSAGVGRTGTFIVIDVMlQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYI
.|||| || ||||. ||  .. .. . ||. ..| . .. | . .  |.   |  
vvvHCkaGkGRtGvlivayll.kslllekaeealelfaeaRtknkkgvtiPsqrR

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 214-279 1.9e-21 70.2 In-house 1-66 (69) alignment
Range on Protein: 214-279
Range on HMM: 1-66/69.0
VVHCSAGVGRTGTFIVIDVMLQQIHEEKTVDILGFVSTLRRHRNLMVQTEQQYIFIHDALLDAIIS
|||||.| ||||||| | | . .|  || |||.  |  .|. | .||  | .|.|||||| .|.  
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealkl

0051299 (Phosphotyrosine protein) phosphatases II 280-570 2.8e-97 320.9 In-house 1-286 (288) alignment
Range on Protein: 280-570
Range on HMM: 1-286/288.0
GETETSASDLRSHIRRLQeqdpESGYTPMFTEFQKLSRCINSsLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFI
|.|| |...|......|.     .|.| .. ||..| ... . |.|.|| .| |. |||| ..|||| .||.||.  ||||||||||.|||||  ||.||
gdteisveellklvlkll....angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfI

ATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQPITFGSLVVEMQDKVKSGHLVVRIFKLTNT----EVSASRDVRQFHYTSWTEE
|||.| |.|. ||||||||||. .||.| ..||  . |...||| ....|.| ..|.. . .. .. .|| ...||.      . || |..||||.| . 
atqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdh

NPLEdglSRCQLIDLIGQVQYWQAeSGRHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
.  .   |  .|.|.. .|. ..| || .|..|||||||||||.|.|. .|.|.|..| .|||...||.|||||| ||||  || |.|...||||
gvpd...spellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 280-574 2.5e-95 314.2 In-house 1-294 (298) alignment
Range on Protein: 280-574
Range on HMM: 1-294/298.0
GETETSASDLRSHIRRLQEQDPESGYTPMFTEFQKLSRCIN--SSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRT
|.|| .|.||. ....|.. ... . | . .|||.|..  .   . . ..| .| ||.|||||.....| .||.|. . . | |||||| ....|  . .
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

FIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENP
|||||||..||. ||||||.|..  ||| | . .|. | |.|.||| ..  |.|.. |... | . . |.|| .|....... .| |||.|.|||...  
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgv

LEdglSRCQLIDLIGQVQYWQAESGRHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLASFE
 |     . ..||. .|. .| ..| .|.||.|||||||.| |.|.. ..||.|.| .|||||.|| ||..||..|||. || |.|..|||.|.||.
pe...natsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfn

subfamily_PTPRB_pd Subfamily PTPRB 285-571 1.4e-85 281.9 In-house 8-286 (293) alignment
Range on Protein: 285-571
Range on HMM: 8-286/293.0
SASDLRSHIRRLQeQDPESGYTpmfTEFQKLSRcINSSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAP
..... .|..... .| . ...    |...|.  .... . .||...||. |||| |.|||| .||.|.   . .||||||||||.|| ..| ||||| |
klekfeehvkkmk.adsdlrfs...eeyeelka.vgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGP

IPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGK-QPITFGSLVVEMQDKVKSGHLVVRIFKLTNteVSASRDVRQFHYTSWTEENPLEDgls
.|||. ||||||||... .|| | | ||. | | ..||| . .|...|.. |... . .  . |.| .|...   ...|.|||.|.|||.. .  |.   
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPek...

RCQLIDLIGQVQYWQ-AESGRHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLA
  .|.|.. .|. ..  .. ..||.|||||||||||.| |.  |..... | .||.| .| .|||.|  .|||. || | .|.||..| 
tktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr

subfamily_PTPN6_pd Subfamily PTPN6 285-571 5.9e-71 234.0 In-house 5-298 (306) alignment
Range on Protein: 285-571
Range on HMM: 5-298/306.0
SASDLRSHIRRLQEQDPESGYTPMFTEFQKLSRC-INSSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSmQVGVEGSDYINANYIDGYMA--KRTFIAT
 |.........|.... . . . .  ||..|..   .. || . ...| ||.|||| |.||.| ||| |. . .| ||||||||||.. .   ....|||
lakeieqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiat

QAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQ-PITFGSLVVEMQDKVKSGHLVVRIFKLT-NTEVSASRDVRQFHYTSWTEENPLE
|  ...|..|||||||..|.  || . .|||..| |  |||| ..   ..|.. |.. .. .  . ..| .... ... . .|.|.|.|..|| ...  .
qgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpk

DGLSRCQLIDLIGQVQYWQAESGRHPIIVHCSAGVGRTGVFCAVSILIERLK---AEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLA
|     .... . . |   .|.   ||.||||||.|||| |  . ||.. ..    .| .|. ..||..||||  .|||. || | |... .|. 
dpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 289-571 4.6e-78 257.2 In-house 2-277 (281) alignment
Range on Protein: 289-571
Range on HMM: 2-277/281.0
LRSHIRRLQEQDpESGYTpmfTEFQKLSRcINSSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPET
|| |...|...| ..|..   .|..||.  |. . . .|.... |. |||| |.  || |||... .   . .||||||...||  .. .||||.|.|..
lrkhlkqlsqnd.naGfi...eeyeklaa.igvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPas

IPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQ-PITFGSLVVEMQDKVKSGHLVVRIFKLtNTEVSASRDVRQFHYTSWTEENPLEdglSRCQL
. .||.|||||. ..|| ...|.|. | | ||||| ..  ...| ..|... . .. . . | ||| ..| . .|.|.|..||.| .    .   .  .|
lvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPa...ttkel

IDLIGQVQYWQAESGRHPIIVHCSAGVGRTGVFCAVSILIERLKAE-AMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLA
..   .|.  . ..  .|...||||||||||.. |.  |.....|| ...|| ..|..||..|  ||||  ||.| |..||..| 
lefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 289-570 1.2e-59 197.0 In-house 7-279 (439) alignment
Range on Protein: 289-570
Range on HMM: 7-279/439.0
LRSHIRRLQEQDPESgYTPMFTEFQKLSRCINSSLSLNAatHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPET
.. |. .|. .. |  .. .| . .  |   .   || |  .  .. |||| .| ..| ||| |    ||  | |||||||.||  .. .||||.|  ||
fqehvekldknkqei.fkeifekinstspdyaciaslaa..qeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkket

IPDFWRMVWEQNCCTIVTLAQEVEQAKakmhrYWPGKQPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVS--ASRDVRQFHYTSWTEENPLEDglsRCQ
  ||||.|.|... |||.|.. ||  |     ||| .. . .| ..| .. ...  . |.| ||. |   .    | | ||||..| ..|   .      
tddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaq...ash

LIDLIGQVQYWQAESGRHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
..|..  ..  . .    |..|||||||||||   |. | .|.||.|  ||.   || ||.||  |||.  || | |. ||| .
vldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi

0039614 (Phosphotyrosine protein) phosphatases II 291-571 6.8e-87 286.9 In-house 17-290 (297) alignment
Range on Protein: 291-571
Range on HMM: 17-290/297.0
SHIRRLQEQDPESGYTPMFTEFQKLSRCINSslsLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGV-EGSDYINANYIDGYMA-KRTFIATQAPIPET
|.. .|.  .. .. | ...||..| ... .      | .|.|| |||| ..|||| .||.|..  || ..||||||.|.|||   .|.|||||.| |||
svldlllllekansktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpet

IPDFWRMVWEQNCCTIVTLAQEVEQAKaKMHRYWPGKQPiTFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSasRDVRQFHYTSWTEENPLEDGLSRCQLI
. |||||||||.. .||.| ..||  . | ..||| ..  |.| ..|.. .  . .. .|| ...||.. |  | |..|.||.| . .. ..  . ....
vedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtnnges..rtvthfqytgwpdhgvppslelllefl

DLIGQVQYWQaeSGRHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLA
.|. ... .   .. .|..|||||||||||.|.|  ...|.|. |  |||...||.|||||| .||| .|| |.|...||.| 
elvrealael..pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk

0045450 (Phosphotyrosine protein) phosphatases II 294-570 1.7e-87 289.3 In-house 15-304 (307) alignment
Range on Protein: 294-570
Range on HMM: 15-304/307.0
RRLQEQDPESGYTPMFTEFQKLSRCINS-SLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGV-EGSDYINANYI--------DGYMAKRTFIATQA
  |. ... .. | .. ||.|| ..    . . ..| .|.|| |||| ..|||| |||.||   |  |.||||||.|.        |||  ||.|||||.
lllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqg

PIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGK-QPITFGSLVVEMQDKVKSGHLVVRIFKLTNT-EVSASRDVRQFHYTSWTEENPLEdg
| |||. |||||.|||.. .||.| ..|| .. | ..||| . ...|.| ..|.. .. . ....|| ...|.. . . || |..||||.| . .  .  
PlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpp..

lSRCQLIDLIGQVQYWQAES-GRHPIIVHCSAGVGRTGVFCAVSILIERLKAEAM---VDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
 |  .|.|.| .|. ...|. . .|..|||||||||||.|.|  .....|..| .   ||....||.|||||| .||. .|| |.|...||.|
.sfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 294-574 1.9e-68 225.5 In-house 8-282 (287) alignment
Range on Protein: 294-574
Range on HMM: 8-282/287.0
RRLQEQDPESGYTPMFTEFQKLSRCINSSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSmqvgVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFW
 .. ..... | .   . |. | .  ..  ..  .  . || |||....|..|  || |      |  ||||| .||||  |. ||....|. .|. .||
gefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfW

RMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQPITFGSLVVEMQDKVKSGHLVVRIFKLTNTE-VSASRDVRQFHYTSWTEENPLEDGLSRcqlIDLIG
......|  .|| |.|| |. . . ..||| .. ...|   .|. .. .. . ..| ....|..  .. . |.|...|.| ..  ...  .    . .| 
kliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqti...llvie

QVQYWQAESGRHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLASFE
.    |  .|. .|.||||..|||...|||. . |.. | |  .|||| .|. | |.| .|||  || | ...||||| |||
emyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfe

0050432 (Phosphotyrosine protein) phosphatases II 296-572 9.2e-95 312.8 In-house 32-301 (308) alignment
Range on Protein: 296-572
Range on HMM: 32-301/308.0
LQEQDPESGYTPMFTEFQKLSRCINsSLSLNAATHPVNKRKNRYANVLPYDVTRVRLsmqvGvEGSDYINANYIDGY--MAKRTFIATQAPIPETIPDFW
|.  ..  ... ...||..| .. . .|. ..| .| || |||| ..|||| .||.|    . ||||||||.|.|||    .|.|||||.| |.|. |||
lkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFw

RMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGK---QPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEDglsRCQLIDL
|||||||. .||.| ..||  . |...||| .   .....| ..|.. .  . .. .|| ..|||.. . || |..||||.| . .  ..     .|.|.
rmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPps...peilldf

IGQVQYWQaesGRHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLAS
. .|. ..   . .||.|||||||||||.|.|. .|.|.|..| .||||..||.|||||| ||||. || |.|...|||| .
lelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl

0047943 (Phosphotyrosine protein) phosphatases II 299-570 1.7e-90 298.5 In-house 5-272 (273) alignment
Range on Protein: 299-570
Range on HMM: 5-272/273.0
QDPESGYTPMFTEFQKLSRCINsSLSLNAATHPVNKRKNRYANVLPYDVTRVRLsmqvGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWE
 .. .|.| .. ||..| .... .|. ..| .| || |||| ..|||| .||.|    | .|||||||.|.|||  ||.|||||.| |.|. ||||||||
lekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvwe

QNCCTIVTLAQEVEQAKAKMHRYWPGKQ---PITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEdglSRCQLIDLIGQVQ
||. .||.| ..||  . | ..||| ..   ..|.| . |.. .  . .. .|| ..|||.. . || |..||||.| . .  .   |  .|...| .|.
qnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvpp...slesllefielvr

YWQAES-GRHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
 ..... . .|..|||||||||||.|.|. .|...|..| .|||...||.||.||| ||||  || |.|...||||
kalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 299-568 6.2e-78 257.3 In-house 27-289 (319) alignment
Range on Protein: 299-568
Range on HMM: 27-289/319.0
QDPESGYTPMFTEFQKLSRCINSSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWE
.| .   | .  ||.....   .    . |  . || |||. |.|..| ..|.|   .|.|.|||||| ...||  |  .||.| | ..|. |||||.||
sdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiwe

QNCCTIVTLAqeveqaKAKMHRYWPGKQPITFGSLVVEMQDKVKSGHLVVRIFKLTN-TEVSASRDVRQFHYTSWTEENPLEDGLsrcQLIDLIGQVQY-
.||.||| |.      | |  .||| |  |. .   |...   ..   ||| ..|.. ..    |...|||.  | .    . .    .|. |. .|.. 
yncstivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdyps...dlmrlvkkvrhl

WQAESGRHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLE
 . | .|..|.||||||||||||. .. .|..|.| | .|||...|..||.||. .||   || |.|  .||
tskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_PTPN12_pd Subfamily PTPN12 299-570 2.1e-77 254.9 In-house 4-277 (290) alignment
Range on Protein: 299-570
Range on HMM: 4-277/290.0
QDPESGYTPMFTEFQKLSRCINSS--LSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMV
.. |  ..  |....|||.   ..   | .|.....|..|||| ..|||| .|| || . ..|||||||||.| |   | ..||.|.|.|.|. |||||.
kegeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmi

WEQNCCTIVTLAQEVEQAKAKMHRYWPGK--QPITFGSLVVEMQ-DKVKSGHLVVRIFKLTNTevSASRDVRQFHYTSWTEENPLEdglSRCQLIDLIGQ
||.|   .| . .||| .| | .|||| .  ....||.. |... .|  .  ...| .|...   ..|| |.|||||.| . .  .   |  .|..|| .
weknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPs...sakslleliel

VQYWQAeSGRHPIIVHCSAGVGRTGVFCAVSILIERLKAEAM---VDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
|.  |  |  .|..|||||||||||. .|. .  | |||| .   .|||. | .||.||.|.|||| || . |. |.|..
vrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv

0036941 (Phosphotyrosine protein) phosphatases II 301-572 7.5e-89 293.2 In-house 8-279 (297) alignment
Range on Protein: 301-572
Range on HMM: 8-279/297.0
PESGYTPMFTEFQKLSRCINsSLSLNAATHPVNKRKNRYANVLPYDVTRVRLsmqvGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQN
. .... . .||..| .... . ||..|  | |. |||| ..|||| |||.|    . ||||||||.|.|||  ||.|||||.| |.|. ||||||||||
kllflalllkefeellplll.lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqn

CCTIVTLAQEVEQAKAKMHRYWPGK--QPITFGSLVVEMQDKVK--SGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEdglSRCQLIDLIGQVQY
. .||.| ..||  . | ..||| .  ...|.| ..|....  .  ... ..| ...|.|. . || |..||||.| . .. |   |  .|.|.| .|. 
vtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpe...spaslldfielvrk

WQAES-GRHPIIVHCSAGVGRTGVFCAVSILIERLK---AEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLAS
..... . .|..|||||||||.|.|.|. .....|.    |  ||....||.|||||| .||| .|| |.|...||.| .
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk

subfamily_PTPRG_pd Subfamily PTPRG 302-572 8.7e-77 253.6 In-house 18-289 (563) alignment
Range on Protein: 302-572
Range on HMM: 18-289/563.0
ESGYTpmfTEFQKL-SRCINSSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGS-DYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQ
. |..    ||..| |..|...|  ... .| ||||||| |...|| .||.||   |.... |||||||||||  .. ||||| |...|. |||||.|||
digfs...eefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeq

NCCTIVTLAQEVEQAKAKMHRYWPGKQPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVS------ASRDVRQFHYTSWTEENPLEDGLsrCQLIDLIGQ
|  .||.... ||. . | ..|||  ...|.|.| | .... .     || ... |...         . |||.|||.| . .  |  |   .||  . .
nvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehsl..pvLifvkks

VQYWQAESGrhPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLAS
 .  .|| |  ||.|||||||||||...... |......| .|.||...|..| ||. .|||. || | ....|| .||
saankaeaG..PivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias

0043336 (Phosphotyrosine protein) phosphatases II 303-570 2.6e-87 288.1 In-house 17-277 (278) alignment
Range on Protein: 303-570
Range on HMM: 17-277/278.0
SGYTPMFTEFQKLSRCINssLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCC
...| .  ||..| ..     . . | .| || |||| ..|||| .||.||.  |...||||||.|.|||  .|.|||||.| |||. ||||||||... 
nlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvt

TIVTLAQEVEQAKAKMHRYWPgKQPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEdglSRCQLIDLIGQVQYWQAeSG
|||.| ..||  . | ..||| ....|.| ..|....  . .. .|| ...||.  . || |...||..| . .  |   |  .|.|.. .|. ... . 
tivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpe...slsllldflkavreale.ds

RHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
 .|..|||||||||||.|.|. .|.|.|. |  ||....||.|||||| .|||  || |.|...||||
ngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 303-570 1.4e-38 127.6 In-house 13-277 (307) alignment
Range on Protein: 303-570
Range on HMM: 13-277/307.0
SGYTPMFTEFQKLSRCINSSLSLNAAThpVNKRKNRYANVLPYDVTRVRLSMQvGvEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCC
 | . .  ||..|..    ... .| .   |  |||| .|   | .|. . .. |   |||| |||.   .  . ||..| |  .|. .|| |. ...  
kgvqalvdefrvlakktpegvtveafs..antdknryqdvkcqdkgrivvkfd.g.lasdyihanylgiaikpkkficaqgplentqysfwamaiqekve

TIVTLAQEVEQAKAKMHRYWPGKQ--PITFGSLVVEMQ-DKVKSGHL--VVRIFKLTNTEVSASRDVRQFHYTSWTeeNPLEDGLSRC--QLIDLIGQVQ
... |.. .| || | ..||| ..    .||.    .  ... ...|     . ..|. .|  ... |  ..  |.  |  . |  .     |.|.  |.
svimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwe..nwpdrgvpqinltainlleavr

YWQaesgrHPIIVHCSAGVGRTGVFCAVSILIERL-KAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
| .      |..|||||||||.|   |.|.. ... . .   |. . |..||.||.  .||. || . ..|.|||.
ydt.....npvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 303-570 4.1e-31 102.9 In-house 19-287 (305) alignment
Range on Protein: 303-570
Range on HMM: 19-287/305.0
SGYTPMFTEFQKLSRcINSSLSLNAATHPVNKRKNRYANVLPYDVTRVRLsmqVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCC
 | . . .||. . | .|    ..|  .  .. |||| .|   |  ||.|    |    .|| |||.      . || ||||. .|  ||| | ....  
kgpaglraefvamkr.fndfekmkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkve

TIVTLAQEVEQAKAKMHRYWPGKQP--ITFGSLVVEMQDKVKSGH----LVVRIFKLTNTEV------SASRDVRQFHYTSWTEENPLEDGlsrCQLIDL
.|  | . .|.   | . |.. |.   ..|      .. |..| .          |.|.|..      . .| | ..|.  | .            ...|
aifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaad...lailel

IGqvqywQAESGRHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVF-QTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
.      .| . . ||.||||||.||||    .  ....| |  ...   . ....||||   .||  || | .||.|.|.
le.....karpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 304-574 7.6e-140 460.5 In-house 18-284 (318) alignment
Range on Protein: 304-574
Range on HMM: 18-284/318.0
GYTPMFTEFQKLSRCINSSLSLNAaTHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCT
|.. ...|...|||. ... ||.. ..||||.||||||.|.|| |||.|.|..|.||||||||||||||..|...||.|||.||||.||||||||||...
Gelllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsav

IVTLAQEVEQAKAKMHRYWPGKQPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEDGlsrCQLIDLIGQVQYWQAESGR
||.|.||.|..|||.|||||.|.....|.||||....|.....|.| ||.|.||...||.|||.|||||..|. .|.|   ..|.||..||...|..||.
ivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesg...aslldlvrqvskaqqksga

HPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLASFE
.||.|||||||||||||.||.||.||.||||.||||||||||||||..||||. ||.|.|.|.||.|||..
gpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgd

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 304-568 2.6e-81 267.8 In-house 19-277 (288) alignment
Range on Protein: 304-568
Range on HMM: 19-277/288.0
GYTPMFTEFQKLsRCINSSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCT
. | .  |...|   .... | .|. ..||..|||| |.|||| .||.|     ..|.|||||.||||.  |...||||.|...|. |||..|.|..  |
nrtgfseeynsL.aalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktst

IVTLAQEVEQAKAKMHRYWPGKQ-PITFGSLVVEMQDKVKSGHLVVRIFKLTntEVSASRDVRQFHYTSWTEENpLEDglSRCQLIDLIGQVQYWQAESg
|| |.. ||. | | ..||| .. |  .||. |..... . .. |.| . |        ... |..|..|....   .  |  .|..|. ||.  . .  
ivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhg.vPe..skapllellrqvkvanqad.

RHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLE
  ||||||||||||||.| |.  ||.....| ..||. ||..||.||. .|||. || |.|.|.|.
tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls

subfamily_PTPN23_pd Subfamily PTPN23 305-569 2.7e-64 211.7 In-house 17-279 (288) alignment
Range on Protein: 305-569
Range on HMM: 17-279/288.0
YTPMFTEFQKLSRCINSSLSLNAAThpVNKRKNRYANVLPYDVTRVRLSmqvgVEGSDYINANYIDGYMAK-RTFIATQAPIPETIPDFWRMVWEQNCCT
    | |...     . . |. .|   ..  |||. ..|||| .|| |      .  ||||| .. .  .   .|||||||...|. |||.||.||   .
ldkkfkeleqkqdkearkrsiaiak..lyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssv

IVTLAQEVEQAKAKMHRYWPGK--QPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEE-NPLedglSRCQLIDLIGQVQY---W
|| | .. |. | |..|||| .  .. .|| | | .... .... | |..||.  ...| ..|.  ..|||.|   |     |  .|......|.     
iVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPa....sPetllqfldevesayea

QAESGRHPIIVHCSAGVGRTGVFCAVSILIERLK-AEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEY
. .  . |..|||||||||||||. |   .. |.  . ..|. | |..|||||  |||.| |. |.|..|||.
vqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea

subfamily_PTPN1_pd Subfamily PTPN1 305-568 6.7e-55 180.8 In-house 8-269 (290) alignment
Range on Protein: 305-568
Range on HMM: 8-269/290.0
YTPMFTEFQKLSRcinsSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGvegsDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTI
|...... .| ..     .. ..| .| |. .||| .| ||| .|..|  .      |||||. ..   ||| .| || |.|.|.  ||.|||||.. ..
ykeiyldirkeas....dfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskav

VTLAQEVEQAKAKMHRYWPGKQP---ITFG--SLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEDGLSRCQLIDLIGQVQYWQA
| | . ||. . | ..||| ..    ...   .| |..  . .. . .||...|.| .   .|.. .||||.|..    |   .  ...  . .    . 
vmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslss

ESGrhPIIVHCSAGVGRTGVFCAVS---ILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLE
. |  | ..|||||.||.| || |    .|||. .  . ||. ... .||..|  ..||. | .| |. .||
dvG..pavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile

subfamily_PTPN14_pd Subfamily PTPN14 306-571 5.5e-61 201.2 In-house 23-297 (300) alignment
Range on Protein: 306-571
Range on HMM: 23-297/300.0
TPMFTEFQKLSRCINsSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVeGSDYINANYIDGYMA--KRTFIATQAPIPETIPDFWRMVWEQNCCT
. .|||......  .    |..|. |.|..|||. .||||. .||.|| .     ..||||  |   ..  .|..|..|.|.. |. |||.|||||.   
gkvfteyeripkkre.dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvql

IVTLAQEVEQAKAKMHRYWPGK----QPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEDGLSRCQLIDLIGQVQYWQA
|| |..| |. | | ..|.| .    . ..||   |  . . .|. .. . .||     .  |.|  . || |....  ||  .  . .. .  |..   
ivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktn

ESG-----RHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLA
..      . |..||||||||||||   . .||. |. .  .|. .....|||||  .||| .|| | |.|...|| 
seveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk

0049772 (Phosphotyrosine protein) phosphatases II 306-571 1.8e-48 161.2 In-house 19-281 (314) alignment
Range on Protein: 306-571
Range on HMM: 19-281/314.0
TPMFTEFQKLSRCINSSLSLNAATHPVNKRKNRYANVLPYDvTRVRLsMQVGVEGSDYINANYIDGYmakRTFIATQAPIPETIPDF----------WRM
. .. ..  .|  . ..|.. .| ...|. |||| ..||.| .||.|   ..|.|||||||.|.||.   ..|||||.| ..|. ||          |||
lklllvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrm

V--WEQNCCTIVT---------------------LAQEVEQAkakmhrywPGKQPITFGSLVvemqdkvksghlvvrifKLTNTEVSASRDVRQFHYTSW
|  ...|. .||                      | .  ..         .   . ..  |                  . ..     .| . ..... .
vlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng........neptaadlellk.................eelydpelferlgikylripv

TEENPLedglSRCQLIDLIGQVQYWqaeSGRHPIIVHCSAGVGRTGVFCAVSILIERLKaeamVDVFQTVKQLREQRP-----AMVQTKGQYDFCYQVVL
. ...     .  .. ...  .. .   .  .|..|||.||.||||.|... .|. .|.    |.. ......|..||      ....  || |.....|
pDgsap....lledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefileall

EYLA
||| 
eylk

0040438 (Phosphotyrosine protein) phosphatases II 307-570 5.8e-90 297.1 In-house 19-276 (317) alignment
Range on Protein: 307-570
Range on HMM: 19-276/317.0
PMFTEFQKLSRCINSslSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVT
 .  ||..| ... .  . . | .|.|| |||| ..|||| .||.||   |...||||||.|.||.  ||.|||||.| |.|. |||||||||....||.
alleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivm

LAQEVEQAKAKMHRYWPGKQPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEdglSRCQLIDLIGQVQYWQAeSGRHPI
| ...|  . | ..||| ....|.| ..|.... .. .. ..| ....... | || |..||||.|.. .. .   |  .|.|.. .|. ... .. .|.
LteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvpp...spdllldfleavreale.dpggpv

IVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
.|||||||||||.|.|. ...|.|. |  |||...||.|||||| .||| .|| |.|...||||
lVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl

0046845 (Phosphotyrosine protein) phosphatases II 308-572 1.2e-90 299.0 In-house 2-276 (284) alignment
Range on Protein: 308-572
Range on HMM: 2-276/284.0
MFTEFQKLSRCINSSL-SLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGV-EGSDYINANYIDGY-----MAKRTFIATQAPIPETIPDFWRMVWEQN
.. ||..| ..  . | ||..| .| |. |||| ..|||| .||.|..  |  |.||||||.|.|||     . |..|||||.| |.|. ||||||||||
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

CCTIVTLAQEVEQAKAKMHRYWPGKQ-PITFGSLVVEMQDKVKSGHLVVRIFKLTNTE-VSASRDVRQFHYTSWTEENPLEDglsRCQLIDLIGQVQYWQ
. .||.| ..||  . |...||| .. ..|.| . |.. .. . .. .|| ..|||..  . || |..|||||| . .  ..     .|.... .|. ..
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvpps...pedlleflrlvrell

AE-SGRHPIIVHCSAGVGRTGVFCAVSILIERLKAEA---MVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLAS
 . .| .||.|||||||||||.|.|. .|.|.|..|    .|||...||.|||||| ||||  || |.|...|||| .
enlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl

subfamily_Ptp69D_pd Subfamily Ptp69D 308-570 2.3e-79 261.7 In-house 24-286 (307) alignment
Range on Protein: 308-570
Range on HMM: 24-286/307.0
MFTEFQKLSRCiNSSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTL
.  |..|| .  ....| ... .  |. |||| .. ..| |||.|.   | | ||||||..| ||  |..||| |.|. .|| |||||..||.  .|| |
lakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivml

AQEVEQAKAKMHRYWPGKQPITFGSLVVEMQDKVKSGHLVVRIFKLTNTE-----VSASRDVRQFHYTSWTEENPLEDGLSrcqLIDLIGQVQYWQAESg
... |. ..|...|||  . . .|...|.. .. | .. . | .......     | .|| | |.|||.| . .  |   .   |..|| ||.  .  . 
snlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevarg...llklieqvrelykln.

RHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
| ||.|||||||||.|.| |...|...||||  ||.|.|||.||.||. .||   || |.|. .|.| 
rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldys

subfamily_PTPN3_pd Subfamily PTPN3 308-568 5e-63 207.6 In-house 17-273 (280) alignment
Range on Protein: 308-568
Range on HMM: 17-273/280.0
MFTEFQKLSRCiNSSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQvgvEGsDYINANYID----GYMAKRTFIATQAPIPETIPDFWRMVWEQNCCT
....|..| |  . .|...||  | |  |||| ..|||| |||.|. .   |  |||||||..    .  .   .|||| |...|  |||.|||||.. .
vlaqfeqlyrk.kpglaisaarkpenlsknryrdilpydatrvklkes...et.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssl

IVTLAQEVEQAKAKMHRYWPGK-QPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEDglsRCQLIDLIGQVQYWQaESG
|| |.. ||. . | |.||| . . ...|.. |... . ..   |.| . |...| . .| . |. |..|....  .|     ...... .|.  . .. 
ivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPdd...sadflefvervrklr.sgk

RHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLE
..|..||||||.|||||. .. . .  . |.  | . . |...|.|| ..|||..|| |  . .|.
eePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk

subfamily_CG42327_pd Subfamily CG42327 308-475 1.1e-25 85.0 In-house 7-174 (319) alignment
Range on Protein: 308-475
Range on HMM: 7-174/319.0
MFTEFQKLSRCINSSLslnaATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYM-AKRTFIATQAPIPETIPDFWRMVWEQNCCTIVT
.. ||..| . | ..     .  .  | |.|..||.|   ||| |  .   . . |..|.|. ||  |.  .||.|..  ..  ||||.||||.  .||.
vaeefrdlPqliarad....evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivq

LAQEVEQAKAKMHRYWPGKQPI----TFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYtSWTEE
|..  |.   .  .|.| |.      ..| . | ....    . ..  . | . . . ||..  . |  | | 
ltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwlea

DSPc_SM00195 309-570 7.8e-87 286.3 In-house 3-262 (263) alignment
Range on Protein: 309-570
Range on HMM: 3-262/263.0
FTEFQKLSRCINSSlSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLA
 .||.|| .  ... . . | .. ||.|||| |.|||| |||.|. . . |||||||||||.|.  |...||||.| |.|. ||||||||... .||.| 
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

QEVEQAKAKMHRYWPGK--QPITFGSLVVEMQDKVKSG-HLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEDGLSrcqLIDLIGQVQYWQAESgRHP
.|.|. | |..|||| .  .. |||.. |..... |   ....| ..||... . .|.|.|..|..|....  ..  |   ...|. .|. .. .|  .|
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstks...vlellravkksksts.sgp

IIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
|.|||||||||||.|....|....|..| .||.|..||.||.||| ||||. || |.|...|||.
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 309-570 7.8e-87 286.3 In-house 3-262 (263) alignment
Range on Protein: 309-570
Range on HMM: 3-262/263.0
FTEFQKLSRCINSSlSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLA
 .||.|| .  ... . . | .. ||.|||| |.|||| |||.|. . . |||||||||||.|.  |...||||.| |.|. ||||||||... .||.| 
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

QEVEQAKAKMHRYWPGK--QPITFGSLVVEMQDKVKSG-HLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEDGLSrcqLIDLIGQVQYWQAESgRHP
.|.|. | |..|||| .  .. |||.. |..... |   ....| ..||... . .|.|.|..|..|....  ..  |   ...|. .|. .. .|  .|
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstks...vlellravkksksts.sgp

IIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
|.|||||||||||.|....|....|..| .||.|..||.||.||| ||||. || |.|...|||.
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 310-574 3.5e-94 310.4 In-house 27-287 (319) alignment
Range on Protein: 310-574
Range on HMM: 27-287/319.0
TEFQKLSRCINSslSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQ
 ||..|.   |   ... |... ||.|||| |.|.|| ||| ||   ||||||||||..||||  .. |||||||. .|| ||||||||... ..| |..
kefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltk

EVEQAKAKMHRYWPGKQPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSA-SRDVRQFHYTSWTEENPLEDGLSrcqLIDLIGQVQYWQAESGRHPIIV
 ||. | |...||| ... ..| |.|..... .  ....| .|| .      .|.| .|.||.|....  |...|   |.||.....  . ..   ||.|
lveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekats...lldllkrirksrektqsgPivv

HCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLASFE
|||||||||| |..... .||.| |...|||.||..|| ||. |||.. || |.|...||.. ...
hCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd

0045098 (Phosphotyrosine protein) phosphatases II 310-571 9e-80 263.3 In-house 13-273 (278) alignment
Range on Protein: 310-571
Range on HMM: 13-273/278.0
TEFQKLSRCInssLSLNAATHPVNKRKNRYANVLPYDVTRVRlsmqvgvegsDYINANYIDGYmaKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQ
.||. |  ..    . . |  . |. |||| ..|||| .||.          |||||.|||||  ...|||||.| |.|. |||||.||... .||.|..
fefllllgip...seitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmlte

EVEQAKAKMHRYWPGKQPITFGSLVVEMQDKVKSGHLVVRIFKLTNT----EVSASRDVRQFHYTSWTEENPLEDG--LSRCQLIDLIGQVQYW------
.|| .. |...||| ....|.| ..|....    .. ..| ...||.    |   || |...||..| . .. ..    |  .|.. | ... .      
lvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslll

---QAESGRHPIIVHCSAGVGRTGVFCAVSILIERLkaEAMVDVFQTVKQLREQRPA-MVQTKGQYDFCYQVVLEYLA
   ..... .|..|||||||||||...|. ...|.|  |  ||....||.||.|||  .||...|| |.|...||.| 
sslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 310-574 4.7e-69 227.4 In-house 24-287 (290) alignment
Range on Protein: 310-574
Range on HMM: 24-287/290.0
TEFQKLSRcINSSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEG--SDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTL
..|..|    .|. . . .. . ||..||.||...||  |. |    | .    .|||| ||.||  |. .||||.|...|. |||...|..... || |
nqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivml

AQEVEQAKAKMHRYWPGKQPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEV-SASRDVRQFHYTSWTEENPLEDGLSrcqLIDLIGQVQYWQAESGRHPI
 ...|. | | . ||| ..  ..|   .....  .  . . | ....|..   |.. | |.. |.| ..  ...  .    . .| ...  |  .|...|
tniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqt...illvieemyktqrkrgntsi

IVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLASFE
.||||..|||..||||. . |.. | |  .|||| .|..| |.| .|||. || . .|.||.|| |||
vvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfe

subfamily_PTPN13_pd Subfamily PTPN13 310-572 5.7e-66 217.6 In-house 15-271 (273) alignment
Range on Protein: 310-572
Range on HMM: 15-271/273.0
TEFQKLSRcINSSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGvegsdYINANYIDGYMAKRTF--IATQAPIPETIPDFWRMVWEQNCCTIVTL
 ||..|   . . .. . . .  ||.|||| |||||| |||.|. . |     ||||..|   . | ..  ||.| |.|||. |||.|||||..  |. .
eefkelre.lkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv

AQEVEQAKAKMHRYWPGK--QPITFGS-LVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEdglSRCQLIDLIGQVQYWQAesGRH
..|.|. | | ||||| .  ....  . | ||. . .|   .||| ......| ..||.| ......| . .      |  .|. .. .|.  |    . 
tlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPs...saaellqfvaevrrlqt..dag

PIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLAS
||.||||||.||.|.. .. .... .. .  .|| ..|..||||| ..|||| || |.|...|| | |
PivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlks

subfamily_PTPRN_pd Subfamily PTPRN 310-568 1.1e-56 186.7 In-house 33-290 (297) alignment
Range on Protein: 310-568
Range on HMM: 33-290/297.0
TEFQKLSRCINSSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYID-GYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLA
 |.. | .  .   . ..| .. | .|||...||||| .||.|. .   | ||||||  |      . ..||||.|...|. |||.||||| .. ||.|.
kewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnlt

QEVEQAKAKMHRYWPGKQPITFGSLVVEM-QDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEdglSRCQLIDLIGQVQywQAESGR-HPI
.  |.   ...|||| .   ...   |..  ... .   .|| | | | . | .| | |||. ||.||.      |   |...  .|.  ..  ||  ||
rleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPa...saksllefrrkvn..ksyrGrscpi

IVHCSAGVGRTGVFCAVSILIERLKA-EAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLE
.||||.|.|||||.... ....||.     .|.  |.. ||.||| .|.|| |..|....| |
vvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 310-569 2.1e-47 156.4 In-house 10-258 (267) alignment
Range on Protein: 310-569
Range on HMM: 10-258/267.0
TEFQKLSRCINSSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQvgveGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQ
 ||... .  . |  .       |. .||. ..|||| ||| |. .      .|||| |..||  |..||.|| |.  || ||. .. .|.. .|| | .
kefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtk....eeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltk

EVEQakaKMHRYWPGK--QPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSAsRDVRQFHYTSWTEENPledglSRCQLIDLIGQVQYWQAESGRHPII
  ..   .....|| |  |   .  |.||   . .     .  ..|   . || ..|  ..|  |  .        .  |  |.| .   | | | .|..
vftd...nirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesa.hnvtlyyykkwnintn.....nkpylkplfgilaknqlengnrPlv

VHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEY
|.||.||||.| |  .   .||.| | ..|.|. ....|.||...|.|| .| ...... ||
vacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 310-567 7.2e-30 98.6 In-house 31-287 (310) alignment
Range on Protein: 310-567
Range on HMM: 31-287/310.0
TEFQKLSRCINSSLSLNAATHpvNKRKNRYANVLPYDVTRVRLSMQVGVEgSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQ
 ...||    .|||. .| ..  .  ||||..|.  | .||.| ..      ||| |||.     . ||| .| |.  || |||||.... . .|. | .
kqyrkldakqdssltyeaykk..ymhknrysdvvcldtsrvklkidksry.edyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllck

EVEQAKAKMHRYWPGKQ-PITFGSLVV----EMQDKVKSGHLVVRiFKLTNTEV---SASRDVRQFHYTSWTEENplEDGL--SRCQLIdliGQVQYwqA
 .|. . |.  |||      |.| . |    |  .. .   | |  |   |  |    |  .  .     | .    . |.   .|. .    |     |
vgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavt.fvpdnvpvdeqpanlkelrvslikwpnwp..drgvpdekchtv...pqrll..a

ESGRHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVL
.    | .||||||..|..| .|. . |..|.    ||. . . .|. .|   .||. || .  .| .
qvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 310-570 2.8e-20 67.1 In-house 26-279 (303) alignment
Range on Protein: 310-570
Range on HMM: 26-279/303.0
TEFQKLSRCINSSLSLNAATHpvNKRKNRYANVLPYDVTRVRLSmqvgveGSDYINANYIDGYMAKRTfIATQAPIPETIPDFWRMVWEQNCCTIVTLAQ
 ||.|..  .  |.| |   .  |  |||...|.  | ..|.||       | || |.|..    |.. | || |.. |  |||.|. ||.   .. |  
nefekvvsylppsvsknqfvk..nmdknrfvdvicldhskvkls......dssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvllllt

EVEQAKAKMHRYWPGKQP-ITFGSLVVEMQ--DKVKS-GHLVVRIFKLTNTEVSASrdVRQFHYTSWTEENPLEDGLsrCQLIDLIGQVQ-YWQAESGRH
. |  |   .  .| .|  . |   .. .    .|.     |...  ..| .  .   .   || .|  ..   ||    ...  | |.| . .  |  .
dseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksf..lhvhhykawphnsipsdgs..pkfvkqiwqlqsvlrkysdst

PIIVHCSAGVGRTGVFCAVSILIERLKAE-AMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
| .    .|.||.| |.        |..| | .|. . ....|. |   ||   |. . | .. |..
ptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv

subfamily_PTPRA_pd Subfamily PTPRA 311-569 4.6e-87 287.0 In-house 37-294 (330) alignment
Range on Protein: 311-569
Range on HMM: 37-294/330.0
EFQKLSRCINSSlSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQE
||. |  .   . .|..|..  ||.|||. |.|||| .|| ||.. ||| |||||| .||||  | .|||.| |  ||. |||||.|||. .||| |.. 
efnalPagpiqa.tlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltel

VEQAKAKMHRYWPGKQPITFGSLVVEMQDKVKSGHLVVRIFKLT----NTEVSASRDVRQFHYTSWTEENPLEDGlsrCQLIDLIGQVQYWQAESGRhPI
 |. . | ..||| .  .|.| . ||..|.. . .. || | ..    .|.  .|| |||||.||| .     ..     ...|. .|.  .  |.  ||
kerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfep...iGmlkllkkvkklnqqsag.pi

IVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEY
.||||||||||| |.... ..||.||| .||||..||.|| ||| ||||. || |.|.|.|||
vvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 311-568 3.8e-76 251.3 In-house 3-253 (284) alignment
Range on Protein: 311-568
Range on HMM: 3-253/284.0
EFQKLSRCINSSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAqe
||.....   .    . |  . || |||. ..|..| ..|.|   .|.|.|||||| .| ||  |  .|||| | ..|. |||||.||.||.||| |.  
efrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt..

veqaKAKMHRYWPGKQPITFGSLVVEMQDKVKSGHLVVRIFKLTN-TEVSASRDVRQFHYTSWTEENPLEDGLsrcQLIDLIGQVQY-WQAESGRHPIIV
    | |  .||| |  |. .   |...   .|   ||| ..|.. ..    |..||||.  | .    . .    .|. |. .|..  . | .|..|.|
....kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdyps...dlmrlvkkvrhltskenhranivv

HCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLE
|||||||||||. .. .|..|.| | .|||...|..||.||. .||   || |.|  .||
hcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 311-570 3.5e-38 125.9 In-house 16-269 (281) alignment
Range on Protein: 311-570
Range on HMM: 16-269/281.0
EFQKLSRCINSSLSlNAATHPVNKRKNRYANVLPYDVTRVRLSMQVG-VEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQ
|| .|     | |   .  .|||..||||.|.   |..||.| ...   . .||| ||||   . || .| || |  ||  |||||.|..|  .|| |.|
efsnlpgdppsdlc.tvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcq

EVEQAKAKMHRYWPGKQ--PITFGSLVVEMQDKVKSGHLVVRIFKLTNTevSASRDVRQFHYTSWTEenpLEDGLSRCQLIDLIGQVqywQAESgrHPII
 .|  . |   |.| .    . |  | |. .|      ||   ..|.      .| . .. .  | .    .   |   .. .. ..   .| |   | .
fletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsye..getrlithwlwkewpd...wqvpessevmlkilrki...rars..tppv

VHCSAGVGRTGVFCAVSILIERLKAE-AMVDVFQTVKQLRE-QRPAMVQTKGQYDFCYQVVLEYL
.||||||||.| . || | .. ...  .. |. | | .||   | | |||  || . ..|.|.. 
ihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfg

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 311-570 3.2e-35 116.2 In-house 32-289 (305) alignment
Range on Protein: 311-570
Range on HMM: 32-289/305.0
EFQKLSRCINSSLSLNAATH-PVNKRKNRYANVLPYDVTRVRLSMQVgveGSDYINANYIDGYM-AKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLA
.. | .|   .   .||     ... ||||..|   | . |.|.       |||| |||.   |  .. ||..| |. .|| .|| || ...   || |.
glakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlc

QEVEQAKAKMHRYWPGK---QPITFGSLVVEMQDKVKSGHLVVRIfKLTNTEVS----ASRDVRQFHYTSWTeenplEDGLSRCQLIDLIgqvQYWQAES
. ||  | |  .|||     .    . .|||     |  .    | ..|  ...     .  ||....| |      . |.  |.|  |           
ktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaei.qitllnltysgdqkmsvrhlqwtewp.....drgvppckltsle...llsairg

GRHPIIVHCSAGVGRTGVFCAVSILIERLKAEA-MVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
 . ||.||||||.||||   |.  ..|..  .     . . || ||.||   .|.  || | ..|.|.|.
skvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 311-372 1.6e-10 35.1 In-house 18-77 (244) alignment
Range on Protein: 311-372
Range on HMM: 18-77/244.0
EFQKLSRCINSSLSLNAAtHPVNKRKNRYANVLPYDVTRVRLSMQvGVEGSDYINANYIDGY
||  ||      |  ||    .|  |||| |.||.| ||| ||     |||||||||||.| 
efvglsdhtreflqtnav.lsanatknryinilpfdetrvilsss.kkegsdyinanyiqgs

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 312-571 1.9e-56 186.0 In-house 21-294 (301) alignment
Range on Protein: 312-571
Range on HMM: 21-294/301.0
FQKLSRCINSSLSLNaaTHPVNKRKNRYANVLPYDVTRVRLSMQ--VGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQ
...|..  . | ...  ..  ||. ||. |. .||  |. |. .  . .   .||||.|||||  |. |||.|.|. .|. ||||..|..   .||....
ykelkegedksctvg..lseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtn

EVEQAKAKMHRYWPG--KQPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVS---------------ASRDVRQFHYTSWTEENPLEDGLSRCQLIDlig
. |..|.| ..|||   ..  .|| . |.....      |.| .... ...|               .|.|| |.. |.| ..  . .     | ||   
lkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqvid...

QVQYWQAESGRHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLA
.| . |   |  |..||||..|.|.||.|.||| .|  |||  ||||| .| .| ..| .|.|  || . |.|. .||.
dvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq

subfamily_ptpA1_pd Subfamily ptpA1 312-531 5.2e-46 152.2 In-house 27-257 (418) alignment
Range on Protein: 312-531
Range on HMM: 27-257/418.0
FQKLSRCINSSLSLNaATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRtFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEV
|. |   .  | . .   .  |  ||||.|.|| . |||.|      |||||||||||||   |. ||.|| |.|.|| ||||||||. |  || |..| 
frlleesvgpsetse.gdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq.fictqgplpntiadfwrmvwenrcriivmlsres

EQAKAKMHRYWPG----K-------QPITFGSLVVEMQDKVKSGH--LVVRIFKLTntEVSASRDVRQFHYTSWTEENPLEDGLSRCQLIDLIGQVQY--
|... |  ||||     .           ||.  ||. . ..     .. |  .||      .||. |..|  | . |  .      ||.  | . |   
encrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirlt..fegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqi

WQAESGRHPIIVHCSAGVGRTGVFCAVSILIERLK
  .     |||||||||||||| ||.  |....| 
ipssdrnvpiivhcsagvgrtgtfctavimmkkld

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 314-572 9.9e-71 233.3 In-house 30-286 (297) alignment
Range on Protein: 314-572
Range on HMM: 30-286/297.0
KLSRCINSSL--SLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAkrTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEV
.  .|. ..   .   | . ||  |.||.|.||||. ||.| .      |||.|| .. |.     .|.|| | ..|. |||.||....  ||| |... 
eeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddn

EQAKaKMHRYWPGKQPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENpLEDGLSRCQLIDLIGQVQYWQAESGRHPIIVHCS
|. | |  |||. |   |||...|...   .    . | ...|. .  | | |.|.....| ...  |   |  .|..|| .|.    .    |..|||.
erdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdka.verkdsassllklisevrkdfsqnaegPllvhcl

AGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLAS
||||||||....   . . | |  ||.|..||.||..|| .|||| || | |..|||.| |
aGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlealls

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 315-568 1e-58 193.5 In-house 15-264 (283) alignment
Range on Protein: 315-568
Range on HMM: 15-264/283.0
LSRCINSSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGvegsDYINANYID---GYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEV
| |    .|. . |.   ||||||. ...|.|. ||.|  .      ||||| .|     |  .. .|..|.|. .|. |||.||.... ..|| |..  
lkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklq

EQAKAKMHRYWPGKQPITFGSLVVEMQDKVKSGHLVVRIFKLTNT-EVSASRDVRQFHYTSWTEENPledGLSRCQLIDlIGQVQYWQAESGRHPIIVHC
|. . |  .||| .  . .| . | ... . |  .... . | .     ..  .  . .  |.| ..   .     |.  . .|.  | || . ||.|||
edlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleyge...qaiinslvk.fnkvislqteskkgPivvhC

SAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLE
|.|.|||.||.|.|  .. ...|..||||..|| .||||. .|||..|| . ...|||
stgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 318-382 1.1e-12 41.9 In-house 33-94 (95) alignment
Range on Protein: 318-382
Range on HMM: 33-94/95.0
CINSSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQvgvEGSDYINANYIDGYMAKRTFIATQ
 . |  .  . .   |  |||. |..||| ||| |. .     |||||| ..|||  |  .||.|
smtsgapytvgsseanipknrflnifpydatrvvlttk...rdsdyinacfvdgyarkncyiaaq

subfamily_PTPN9_pd Subfamily PTPN9 320-570 5.8e-74 243.8 In-house 29-290 (297) alignment
Range on Protein: 320-570
Range on HMM: 29-290/297.0
NSSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMH
. .  ..|. ...| .||||..|| || ||| |. . . | |||||||..|||  |..||||| |...|. |||||||||.. .||  .. ||. . |  
pveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcg

RYWP--GKQPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEDGLSRCQLIDLIGQVQ---------YWQAESGRHPIIV
.|||   .. . ||.| |.  . ... . .||.....|.. . || |  | ..|| .    ... |  .... . . |          |. .    ||.|
qyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivv

HCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
|||||.|||| |... | ..||. ...|||..|||.||.||  ..||  || |||. |||| 
hcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 321-569 1.4e-62 206.1 In-house 26-276 (287) alignment
Range on Protein: 321-569
Range on HMM: 26-276/287.0
SSLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQvGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHR
|.. . ||..  . .|||||.|||.| ||| || . |  |||||||||. .|  . .|||.|.||. |. ||||.|.|.. ....|...|||.|. | ..
statfkaaeelaavkknryadvlPiddtrvllsae.gelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcyk

YWPGK-QPITFGSL-VVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEE--NPLEDGLSRCQLiDLIGQVQYWQAESGRHPIIVHCSAGVGR
||| . .|.  |   || .. ..|. .  || ..| . |   .| |.|... || ..   |   || |  | |   ...  .  |.  |..||...|.||
ywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvl.dvkqhielardasevGPlvvhddvGiGr

TGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEY
.|.. |. .|..||.    ||| ..| .|||.| |.||.  |. . |. .  |
sGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvty

subfamily_PTPRD_pd Subfamily PTPRD 322-573 3.2e-117 387.5 In-house 37-284 (564) alignment
Range on Protein: 322-573
Range on HMM: 37-284/564.0
SLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRY
. . .||..|.||.||||||...|| .||.||.  |.||||||||..||||......||||.|..||| ||||||||||..||| | . .|. | |.|.|
qftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkY

WPGKQPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEDGlsrCQLIDLIGQVQYWQaESGRHPIIVHCSAGVGRTGVFC
|| |.. |.|.|.|.......  . ..| |||.... | || |||||.||| ...  | .   ..|.||| .|. .. |....||.|||||||||||.|.
WPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesa...tslLdlirkvraln.epdagPivVhCSaGVGRTGtfi

AVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLASF
......||.|.|..||..|.||.||.||.|||||. || |.....||.||..
vidamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacg

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 322-572 7.6e-64 210.9 In-house 37-290 (325) alignment
Range on Protein: 322-572
Range on HMM: 37-290/325.0
SLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMV--WEqncCTIVTLAQEVEQAKAKMH
. . ..|..| || |||. ||...| .|| |  .     ||||||.|.  .. | .|.|.||| ..|| |.||.|  |.   |..| .  |... | .  
giakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr...csvvvvlneldlgkdrca

RYWPGK--QPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEDGLSRCQLIDLIGQVQYW-QA-ESGRHPIIVHCSAGVG
 ||| .  .  |||.| |...   .    | |.... ...   .| |.||.. || .    .   .   ...|. .|.   .|   .  ||.||||||||
vywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvG

RTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLAS
||||| ..  .....  |. ||.|. ||.||..||.||.|  || ..|. . |.. |
rtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveayms

subfamily_egg_pd Subfamily egg 322-569 5.4e-30 99.1 In-house 29-269 (307) alignment
Range on Protein: 322-569
Range on HMM: 29-269/307.0
SLSLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQakAKMHRY
  ||. |    |. | |   |   |..||.| .. |    |.| ||...|     .|| .|||. .|  ||||||.....  || |.  .|    . . |
eislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyy

WPG--KQPITF--GSLVVEMQDKVKSGHLVVRIFKLTNteVSASRDVRQFHYTSWTeENPLEDGLSRCQLIDLIGQVqywqaesgRHPIIVHCSAGVGRT
||   .... .  ||| .|  .  .    . |. ||    | . .. |   .  .   | . |  |  ... .. ..         .|..|..  || ..
wpkaesdslvtvpGslrienlkvdskadplfrvtklkl..vGgddeerflehwqgd.vnnssdvysplrvlrklrnl........skpvvvqdilGvska

GVFCAVSILIERLKAEA--MVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEY
... |. | .  |         | ..|. || .|.  |..  .| | |..|| .
atlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlff

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 324-569 4.1e-72 237.8 In-house 40-278 (315) alignment
Range on Protein: 324-569
Range on HMM: 40-278/315.0
SLNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWP
 |. | .  ||.|||| |...|| .||.| .    ..|||.|||.||||  || .||.|.| .... ||||.|.|... .|| |.. ||. | |  .|||
pldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywp

GKqPITFGSLVVEMQDKVKSGHLVVRIFklTNTEVSASRDVRQFHYTSWTEENPledGLSRCQLIDLIGQVQYWQAESGrHPIIVHCSAGVGRTGVFCAV
 |  ...| . | .... .  .. || .  . .  .  |.| |.||||| . .      .   |..|| .|. .. .|   .|.||||||||||| |...
dk.kviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgv...pkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitl

SILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEY
. ......|| ..||.. ....|..|  |||.  ||.| |...|| 
davldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 325-573 1.9e-76 252.1 In-house 38-286 (305) alignment
Range on Protein: 325-573
Range on HMM: 38-286/305.0
LNAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPG
..  .. .||.|||.... ..|  |..|. .  .. ||||||.|.|||  | ..|..|.|...|. ||||...|    ||| |.. ||. | | ..|||.
idvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpe

KQPI--TFGSLVVEMQDKVKSGHLVVRIFKLTN-TEVSASRDVRQFHYTSWTEENPLEDGlsrCQLIDLIGQVQYWQAESGRHPIIVHCSAGVGRTGVFC
..     ||...||.... .   .. | .|...  | . || | |.. |.| ..   .       |..|| .||  | ..   |..|||||||||||||.
sktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfa...tsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfi

AVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLASF
||.| .||||.| .||||. .||||..|. ||||. ||.|..... |.. ..
avdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 325-570 1e-44 147.6 In-house 25-295 (297) alignment
Range on Protein: 325-570
Range on HMM: 25-295/297.0
LNAATHPVNKRKNRYANVLPYDVTRVRLSmqVGVEGSDYINANYID--GYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYW
. .|  .   ||||| ..| .| |||.|    .. ..|||||.|.      |.  .| .| |. .|. |||..|.||.  .|| .|.  |. . |   ||
fssakrnsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapyw

PGK--QPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEEN-P--LEDgLSRC---------------QLID-----LIGQVQYW
|    .  . |..|||   ..   .  | . .|.    | || ||   . || .   |  ||| | |                 |..     .. |..  
psvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdled.lvrfqaqvcscciavpmmlalvemftamvflqlesl

QAESGRH-PIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
.||  |  ...|||||||||.||     .....|. . . ||   ...|||||. .|||  |....|..||. |
raemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl

0037934 (Phosphotyrosine protein) phosphatases II 326-570 8.2e-73 240.2 In-house 3-242 (243) alignment
Range on Protein: 326-570
Range on HMM: 3-242/243.0
NAATHPVNKRKNRYANVLPYDVTRVRLsmqvgvEGSDYINANYIDGYmakRTFIATQAPIPETIPD----FWRMVWEQNCCTIVTLAQEVEQAKAKMHRY
. | .|.|. |||| ..|||| .||.|      |||||||||.|...   ...||||.| |||. |    ||||.||... .||.| ..||  . |...|
siallpenlsknrysdilpydhsrvkl......egsdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPGKQpiTFGSLVVEMQDKVKSGHLVVRIFKLTNTE-VSASRDVRQFHYTSWTEENPLEDGLSRCQLIDLIGQVQY----WQAESGRHPIIVHCSAGVGR
|||..  |.| ..|.. .    .. .|| ..|.|..    .| |...||..| . .. ..  .  ...| . ...     . |... .|..|||||||||
wpgev..tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

TGVFCAVSILIERLkaeaMVDVFQTVKQLREQRPA-MVQTKGQYDFCYQVVLEYL
||...|  .....|     ||....||.||||||  .||| .|| |.|...||.|
tGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallell

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 326-570 1.8e-51 169.8 In-house 38-236 (392) alignment
Range on Protein: 326-570
Range on HMM: 38-236/392.0
NAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAkakmhrywpgk
..| ...|..|||| |.|||| .||.| .   .  |||.|| ||... .....||.|.| . .. ||||||...| .||. ...  |             
tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...........

qpitfgslvvemqdkvksghlvvrifkltntEVSASRDVRQFHYTSWTEENPLEDGlsrCQLIDLIGQVQYwQAESGRHPIIVHCSAGVGRTGVFCAVSI
                                    | | |||.| | ...  .     . |. .| .|.  .  .  ||.|.|||||||||||  ..  
...............................kgddartvaqfhftewPdkdvpkht...ssllkfikevka.dfGqythpliihcsagvgrtgvvisids

LIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
.. . |   |||||. | ..|..|| ||||| || | |  ||| |
vvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 326-372 3.5e-09 30.5 In-house 40-86 (440) alignment
Range on Protein: 326-372
Range on HMM: 40-86/440.0
NAATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGY
. |. | || |||| |.| || .|| |    ||  |||||| ||.| 
diaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi

0040439 (Phosphotyrosine protein) phosphatases II 327-570 5.5e-82 270.4 In-house 5-246 (249) alignment
Range on Protein: 327-570
Range on HMM: 5-246/249.0
AATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQ
 | .|.|| |||| ..|||| .||.||   |...||||||.|||||  ||.|||||.| |||..|||||.||... .||.| ..||  . | ..||| ..
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplgg

PITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEDGLSrcqLIDLIGQVQYWQAES-GRHPIIVHCSAGVGRTGVFCAVSI
....| ..|.. .  ......|| ..|||.. . || |....||.| . .  ..  .   |.|.| .|. ...|    .|..|||||||||||.|.|  .
sleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfed...lldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

LIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
..|.|. |  ||....||.||.||| .||. .|| |.|...||.|
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

0042113 (Phosphotyrosine protein) phosphatases II 327-570 1.1e-80 265.9 In-house 3-243 (245) alignment
Range on Protein: 327-570
Range on HMM: 3-243/245.0
AATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQ
 | .|.|| |||| ..|||| |||.||   | ..||||||.|.|||  ...|||||.| |||..|||||.||... |||.| .|.|  . | ..||| ..
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplge

PITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEDglsRCQLIDLIGQVQYWQAESGRHPIIVHCSAGVGRTGVFCAVSIL
..|.| ..|.. .  . ....||....||.  . || |...||..| . .. ..     .|.|..  |. ..||.. .|..|||||||||||.|.|. ..
sltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdl...lellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylm

IERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
.|.|..|  |.....||.||.||| .||| .|| |.|...||.|
leqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 327-574 2.2e-79 261.2 In-house 3-246 (250) alignment
Range on Protein: 327-574
Range on HMM: 3-246/250.0
AATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAkMHRYWPGKQ
 | .| || |||||.....| .|| |  . | . |||||| ...||. ...|||||.|...|| ||||||.|..  ||| |.. .|. |  .|.||| ..
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek

PITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEDGLSrcqLIDLIGQVQYWQAESGRHPIIVHCSAGVGRTGVFCAVSIL
. ..|.. |.. .| . . ...| .||.... . .| |||.|...| .    |   .    ..|. .||  | ..|  |.||.|||||||.| |.|.. .
aekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevata...vLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidav

IERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLASFE
.|||| | .||||. .|.||..|| .|... || |.|...|..| |.|
lerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsve

subfamily_PTPRK_pd Subfamily PTPRK 327-568 4e-77 254.1 In-house 37-275 (314) alignment
Range on Protein: 327-568
Range on HMM: 37-275/314.0
AATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQ
|| .  |..|||. ..|.|| .||.|    |   ||||||..||.|   . ||.|| |..||. ||||.|...||..|| |.. ||... |  .||| . 
aakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedt

PItFGSLVVEMQDKVKSGHLVVRIFKLTN--TEVSASRDVRQFHYTSWTEEnplEDGLSRCQLIDLIGQVQYWQAEsGRHPIIVHCSAGVGRTGVFCAVS
 . .| . ||. .      ||||||....    ... | ||||....|..    .   |.  |..|. .|. .|.| .  .|.|||||| ||||.|.|..
ev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdh...dvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaid

ILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLE
|... .. | .||||..||.||.... ||.|. || |.|.|.||
ivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 327-571 1.8e-69 229.0 In-house 38-278 (315) alignment
Range on Protein: 327-571
Range on HMM: 38-278/315.0
AATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPG--
.| ...| .|||| |.||.| .||.| .      |||||| || ..   ...||.|.| . .. ||||||....  ||| ...  |. | |  .|||   
varetinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrk

KQPITFGSLVVEMQDKVKSGHLVVRIFklTNTEVSASRDVRQFHYTSWTEENPlEDGLSrcQLIDLIGQVQYWqAESGRHPIIVHCSAGVGRTGVFCAVS
 . . |||. ||. .    .  |.| .  .  .  .|| | ||..| | ..   .  .|   |. || .|.    ..  ....||||||||||||.... 
adsvefGsikvellsleadtdgvarkl..vtrkseesrtvtqfqftewPdkGv.dkqts..sllklikevkad.ngkkefsllvhcsaGvGrtGvvisid

ILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLA
  ....| . .||||..||.||..|| .|||. .| | |..|||.| 
evvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 327-568 7.1e-49 161.1 In-house 2-239 (239) alignment
Range on Protein: 327-568
Range on HMM: 2-239/239.0
AATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYM-AKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGK
|| . ||| ||||||.. || .|| |        ||||||.|.  |  . ...||||  .  .  |||||.|..  | || |.  .|  | | |.|||  
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

QpITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEDGLSrcqLIDLIGQVQYwQAESGRHPIIVHCSAGVGRTGVFCAVSI
    .  | | ..        ..| | ...   .  | | |.|.| | ..   .   .   .. |  ..   ..  | .| ..|||||||||| |  .  
t.skycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyata...vlglrrkitk.dslpgarpwvihcsagvgrtgaflvida

LIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLE
.. . | .  ||.|. || .||.|| ||||  || | .  |||
mlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 327-568 1e-48 160.6 In-house 1-238 (239) alignment
Range on Protein: 327-568
Range on HMM: 1-238/239.0
AATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYM-AKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGK
|| . ||| ||||||.. || .|| |        ||||||.|.  |  . ...||||  .  .  |||||.|..  | || |.  .|  | | |.|||  
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

QpITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEDGLSrcqLIDLIGQVQYwQAESGRHPIIVHCSAGVGRTGVFCAVSI
    .  | | ..        ..| | ...   .  | | |.|.| | ..   .   .   .. |  ..   ..  | .| ..|||||||||| |  .  
t.skycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyata...vlglrrkitk.dslpgarpwvihcsagvgrtgaflvida

LIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLE
.. . | .  ||.|. || .||.|| ||||  || | .  |||
mlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 328-571 4.5e-68 224.6 In-house 38-277 (515) alignment
Range on Protein: 328-571
Range on HMM: 38-277/515.0
ATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPG--K
|   .| .|||| |.|||| .||.| .      |||.|| || .. . ...||.|.| . .. ||||.|...|  ||. ...  |. | |  .|||    
aqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpg

QPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVsaSRDVRQFHYTSWTEENPLEDglsRCQLIDLIGQVQYWQAESGrHPIIVHCSAGVGRTGVFCAVSI
. . |||. ||.      .  . | ....  .   || | |||.| | ..   ..      |. || .|.  . .   ||.|.|||||||||||....  
dsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkh...tssllklikevkadhgqyt.hpliihcsaGvGrtGvvisids

LIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLA
 . . |   |||||..|...|..|| .|||. || | |..|||.| 
vvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 328-427 1.4e-08 27.8 In-house 22-89 (169) alignment
Range on Protein: 328-427
Range on HMM: 22-89/169.0
ATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINAnyidgymakrtfiatqapipetipdfwRMVWEQNCCTIVTLAQEVEQakakmHRYWPGKQP
|   .|. ||| |  |    |||.|   .   |||||||                           ||.|| |   || | .  ..       .|| |. 
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddk.....nnfwpeked





subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 328-429 1.5e-08 27.6 In-house 21-90 (169) alignment
Range on Protein: 328-429
Range on HMM: 21-90/169.0
ATHPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINAnyidgymakrtfiatqapipetipdfwRMVWEQNCCTIVTLAQEVEQakakmHRYWPGKQP
|   .|. ||| |  |    |||.|   .   |||||||                           ||.|| |   || | .  ..       .|| |. 
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddk.....nnfwpeked

IT
  
yq

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 329-571 7.1e-65 213.8 In-house 24-269 (274) alignment
Range on Protein: 329-571
Range on HMM: 24-269/274.0
THPVNKRKNRYANVLPYDVTRVRLSMQVGVEG-SDYINANYIDGYMAK-RTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQ
. . ...|||| ..|| . .|| |. . . .  |.||||||| ||  . ....||| |.|.|. |||||......  || |..  |. ..| ..|.| ..
dvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdae

PI----TFGSLVVEMQDKVKSGHLVVRIFKLTNTEVsaSRDVRQFHYTSWTEENPLEDglsRCQLIDLIGQVQYWQAESGRH--PIIVHCSAGVGRTGVF
 .    ..| . ......|.  .  || . | ..|   .|.|  . ||.| ...  .|     .|.||. .|.  . |.  .  |..||||||.||||.|
dyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPdd...antlldlvleveesreeenaklapvvvhCsaGiGrtGcf

CAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLA
 |.|| . .|..| .|||...| .|| .|  ||||. ||.. .... .|| 
iaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 330-570 8.4e-60 197.0 In-house 17-264 (270) alignment
Range on Protein: 330-570
Range on HMM: 17-264/270.0
HPVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMA-KRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQ--
.  .|. ||||..||  .|||||.     . . ||||||. |.   |...||...| | |. .||||.||..  .|| ... .|. . |  |||| ..  
aargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepke

--PITFGSLVVEMQDKVKSGHLVVRIFKLTntEVSASRDVRQFHYTSWTEE-NPLEDG--LSRCQLIDLIGQVQYWQAESGRH-PIIVHCSAGVGRTGVF
   ...| . |  . ..|.   ...  .|.  | . .| .  |.|..| ..  | |..  ||  ||. .. .|. .. |  .  |..|||||||||||..
kvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtl

CAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
 |. | .. |. .  ||| . ...||..|.|.||.  || | |..|.|| 
ialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya

subfamily_CG7180_pd Subfamily CG7180 331-571 7.3e-66 216.8 In-house 40-291 (296) alignment
Range on Protein: 331-571
Range on HMM: 40-291/296.0
PVNKRKNRYANVLPYDVTRVRLSMQVGVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKaKMHRYWPGKQPITF
  |. |||. .|.||| .|| |.   | | |||||| |.|... |. .| |.||  ||. .|||.|..... ..| |... ..|| ... ||| |.   .
kenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqy

GSLVVEMQDKVKSGHLVVRIFKLTNT----------EVSASRDVRQFHYTSWTEENPLedGLSRCQLIDLIGQVQYWQAES----GRHPIIVHCSAGVGR
| ..||.  . .  .|. | |||| .          ..   | |..|..| |  |. .   ||   ||.|. .|. |. .      . |..|..| |..|
geifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkv..PlstnalielrrrvrlwrekvdedpeegPvvvvssdGasR

TGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLA
.||..|. . .| .. |  ||||. ||.||..|| .|... .| ..|.|.||.. 
sGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 331-570 6.9e-27 89.1 In-house 33-270 (285) alignment
Range on Protein: 331-570
Range on HMM: 33-270/285.0
PVNKRKNRYANVLPYDVTRVRLSMqvgvEGSDYINANYIDGY-MAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQ--P
  |   ||||.|   . ||| |         ||| |...      . |.|.|| |.|||. |||.|..... . .. |.  .|    |   |.| |    
eanpdlnryadvrcieetrvvlkn....hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev

ITFGSLVV---EMQDKVKSGHlVVRIFKLTNTEVSASRDVRQFHYT--SWTEENPLEDGLSrcqLIDLIGQVQywQAESGRHPIIVHCSAGVGRTGVFCA
. ||   .   | ...  .|  ..  . ..||| ..|  .   |     | ..   ||      .|.|   |.  . .   .|| ||||||||||  |  
vkfgkyeitlteckeeaiagt.ilnaltvintedasseplymnhvqvpwwpdqlapedarp...mielykwvk..kvnpkekpicvhcsagvgrtatfvg

VSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
.     |.  .  ..... |...|  |   ||.. |. | | |..||.
idyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 332-571 2.3e-34 113.7 In-house 42-272 (288) alignment
Range on Protein: 332-571
Range on HMM: 42-272/288.0
VNKRKNRYANVLPYDVTRVRLSmqvgVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGK--QPIT
 |  ..|| |.   |.|||.||     .   ||.|| .     || .| .|||.  ||  .|.|. |..   || |.. .|. | |   |.| |  . . 
anptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

FGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRD-VRQFHYTSWTEENPLEDGLSRCQLIDLIgqvqywqaESGRHPIIVHCSAGVGRTGVFCAVSILIE
.| |   ...| .  . .|..  | ....   .  |.. |.  | ..   |. ||  .|.. .        .| ..||.||.|||||||| .  . | .|
igrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl........kslqkPivvhssaGvGrtgtlililiale

RLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLA
 |. .  . . . ...|||.|   .||. || . ...|||.|.
slrlddflgirsllaklreerfkaiqtemqylyvhrcvleell

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 332-559 5.9e-31 102.3 In-house 49-270 (301) alignment
Range on Protein: 332-559
Range on HMM: 49-270/301.0
VNKRKNRYANVlPYD-VTrvrlSMQVGVEGSD-YINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQ--P
..| |.|| .| | .  |    ...| |.|    | ||.|.     . |||||.|...|  ||| |.   .  .|| |.|.||. . |.. | | |    
lpkdkhryptv.PckPst....avevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisek

ITFGSLVVEM--QDKVKSGHLVVRIFKLTNT-EVSASRDVRQFHYTSWTEENPLEdglSRCQLIDLIGQVQywqaeSGRHPIIVHCSAGVGRTGVFCAVS
.  |   ...  .... . ... | ...... .  |.| |  . |..||...  .   |  .| ||.  |.       ..||.||||||.||.  | .  
ldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPk...shaelfdlmelvk.....ksekPivvhcsaGiGrsvafigte

ILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQY
.|  ...|.  ... ...|.|||.|   |||. | 
ylareveadptieltealkhlrehrwngvqtnsql

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 332-570 1.9e-21 70.8 In-house 50-285 (302) alignment
Range on Protein: 332-570
Range on HMM: 50-285/302.0
VNKRKNRYANVLPYDVTRVRLSMQvgveGSDYINANYIDGYMAKRTFIATQAPIPETI---PDFWRMVWEQNCCTIVTLAQEVEQAKaKMHRYWP--GKQ
 | .||.  .|  .| ..|.|...      .|.||  ..    .|. | .| |. ..     .|||||..... ..| |..| |  |  .. ..|    .
knlkknqsedvpildsnlvkleae....pdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgd

PITFGSLVVEMQDkVKSGHLVV--RIFKLTNTEVSASRDVRQFHYTSWTEENPLedgLSRCQLIDLIGQVqYWQAESGRHPIIVHCSAGVGRTGVFCAVS
  ..|.. |  .  |.. .  .   .  .   ..| |  .   . | | ... .    .  .||  . .| . . ... .....    |.|| |.| .. 
ykeygkmfvNnrk.VekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvp...vkyaeliktaakv.fakkikadentvivSknGaGRagafltla

ILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
. .|.|.... . . ..||..|.|||..|..  || . | ..| |.
vaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi

Y_phosphatase Protein-tyrosine phosphatase 333-568 1.3e-79 262.3 Pfam-A 1-235 (235) alignment
Range on Protein: 333-568
Range on HMM: 1-235/235.0
NKRKNRYANVLPYDVTRVRLsmqVGVEG-SDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWP--GKQPIT
||.|||| ..|||| |||.|    | || ||||||||..||  |..|||||.|...|| |||||||.... .||.|....|. . |...|||   ... |
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGSLVVEMQ-DKV-KSGHLVVRIFKLTNTEVS-ASRDVRQFHYTSWTEENPLEDglsRCQLIDLIGQVQYWQaESGRHPIIVHCSAGVGRTGVFCAVSIL
.|.. ||.. ..  .. . ..| ..|.... . ..| |.|.|||.|....  |.     .|.||| .|. .. |. ..|..|||||||||||.|.|..||
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpes...pkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldil

IERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLE
.|.|.||  |||.|.||.||.||| |||.  || |.|...||
leqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 333-568 1.3e-79 262.3 In-house 1-235 (235) alignment
Range on Protein: 333-568
Range on HMM: 1-235/235.0
NKRKNRYANVLPYDVTRVRLsmqVGVEG-SDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWP--GKQPIT
||.|||| ..|||| |||.|    | || ||||||||..||  |..|||||.|...|| |||||||.... .||.|....|. . |...|||   ... |
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGSLVVEMQ-DKV-KSGHLVVRIFKLTNTEVS-ASRDVRQFHYTSWTEENPLEDglsRCQLIDLIGQVQYWQaESGRHPIIVHCSAGVGRTGVFCAVSIL
.|.. ||.. ..  .. . ..| ..|.... . ..| |.|.|||.|....  |.     .|.||| .|. .. |. ..|..|||||||||||.|.|..||
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpes...pkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldil

IERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLE
.|.|.||  |||.|.||.||.||| |||.  || |.|...||
leqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 333-568 1.5e-50 166.7 In-house 3-237 (237) alignment
Range on Protein: 333-568
Range on HMM: 3-237/237.0
NKRKNRYANVLPYDVTRVRLSMQvGvEGSDYINANYIDGYM-AKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPG-KQPITF
|| ||||.|.  || .|| |    |  |||||||.|..|.  . ...||.| |.  .  |||.|||...|  || |.  .|. . | |.|||  .|| ..
nkiknrygnivaydhsrvvlkga.g.sgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GSLVVEMQDKVKSGHLVVRIFKLTNT-EVSASRDVRQFHYTSWTEENPLEDGLSRCQLIDLIGQVQYWQAESGrhPIIVHCSAGVGRTGVFCAVSILIER
| | | .. | .     || . |..  ..   | . |...||| .    .   .  ..   | .     .|||  | |.||||||||||.|  .  .. .
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesg..pwiihcsagvgrtgiflvidamlrq

LKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLE
 | . .||... |. . |.|| ..||| || | .|..||
akekkvvdiynyvysieedrpyiiqtkdqyvfihqtile

0041856 (Phosphotyrosine protein) phosphatases II 333-570 2.7e-48 159.3 In-house 1-171 (182) alignment
Range on Protein: 333-570
Range on HMM: 1-171/182.0
NKRKNRYANVLPYDVTRvrlsmqvgveGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAqeveqakakMHRYWPGKQpitfgs
|. |||| ..|||| .|          ..||||||...|..  ..|||||.| ..|..||.||..|... |||.|.          ..||| .       
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

lvvemqdkvksghlvvrifkltntevsaSRDVRQFHYTSWTEENPLEdglsRCQLIDLIGQVQYwqaesGRHPIIVHCSAGVGRTGVFCAVSILIERlka
                             | . |..|..|   .. .      .|.|.| .|.        .|..|||||||||||...|  .....   
............................erlgiqylylpwpDhgvpd....ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl...

eaMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
   |.....||..|..|| ||.|  || |.....||.|
..gvsleeavklvrsrRpgmvitpnqyfflqlallell

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 333-410 6.3e-11 36.4 In-house 37-119 (347) alignment
Range on Protein: 333-410
Range on HMM: 37-119/347.0
NKRKNRYANVLPYDVTRVRLSMQVG-----VEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQE
.  |||  .|   | ||| || .        .   |||| .|    |.. .| || |.|.|. |||.||   .   .||. . 
slsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifep

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 334-571 4.3e-39 128.9 In-house 57-284 (290) alignment
Range on Protein: 334-571
Range on HMM: 57-284/290.0
KRKNRYANVLPYDVTRVRLSmqVGVEGsDYINANYIDGYmaKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGK--QPITFG
 .|||| .|   |.||| |.   | .| ||. |||..|   | .|| || .. .|. |.|||| ...  .|| | . .|. ||| ..|.| |  . .|||
fkknrykdvvcndktrvilk..dGydG.dyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfG

SLVVEM-QDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPledGLSRCQLIDLIgqvQYWQAESGrhPIIVHCSAGVGRTGVFCAVSILIERL
.. |   ... |  ... ... . . .   .  .. ..  || .       ||   |. ..   .  .  ||  |..||||||.|||| | |. . .. |
eitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksv...alstlallrtl...rilrkasG..pvvvhcsaGiGrtGtfvaievglqil

KAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLA
     .|. ..|. ||. | . ||   ||    ...|..  
ldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGk

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 334-572 6.7e-19 62.7 In-house 44-278 (312) alignment
Range on Protein: 334-572
Range on HMM: 44-278/312.0
KRKNRYANVLPYDVTRVRLSmqvGVEgSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQ-------
|  ||| |.  .|  |  |.   | |   || ||..        |..||.|. .|.  ||...    ...|. |.  ||..  |  .|            
kdlnrypniqcwdrgrftla...gde.nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdled

--PITFGSLVVEMQDKVKSgHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENpLEDGLSRCqlIDLIGQVQywqaeSGRHPIIVHCSAGVGRTGVFCAVS
    |     .|.  | |  ..  |..|.          . .. ..|| .   . |    .    |.  |.       ..|.| |||||||||| .. . 
hrvyteycteieiggkskd.kithrvlkvvvkatgqesklnhyqwaswpdhg.mpdscdta..lrllsavk.....kdkkpviahcsagvgrtgtlalie

ILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLAS
 .|  |.     .| ..   || .|   |..  || .. ..|||.| |
smiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflys

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 334-416 1.2e-09 32.1 In-house 35-116 (332) alignment
Range on Protein: 334-416
Range on HMM: 35-116/332.0
KRKNRYANVLPYDVTRVRLSMQVGVEgsDYINANYIDGYMAKRTFIATQAPIPE-TIPDFWRMVWEQNCCTIVTLAQEVEQAKA
   ||   .  .| .|| |. | | .  |. ||...|||  | ..| .|||. . |   ||||| |..   |. . .  |. | 
mdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkr

subfamily_eak_pd Subfamily eak 335-571 3.3e-24 79.9 In-house 54-306 (332) alignment
Range on Protein: 335-571
Range on HMM: 54-306/332.0
RKNrYANVLPYDVTRVRLSMQVgVEGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQ--PITFGS
..|   ...|||   |||.     .   ||||  ..     | .| | ..  . .. ||.|| ||.  .|| |...||.   |  .|.| |    . || 
nrn.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGi

LVVEMQDKVKSGHLVVRIFKLTNTEvsASRDVRQFHYTSWTEEN-P-LEDGLSRCQLIDLIGQV---------------QYWQAESGRHPIIvHCSAGVG
| || .. || . | .| ..|.  .   .  |  ...  ||| . | .|| |.  . .  .| .               .|  .     |||  .. |  
ldverkefvkrniletrllelskGn..ethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapii.qsarGsa

RTGVFCAVSILIERL--KAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLA
|.|||  . .||. .  | . .  | . . . ...|   | .. |. | |..||.|| 
raGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyll

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 335-424 8.5e-22 72.3 In-house 49-152 (350) alignment
Range on Protein: 335-424
Range on HMM: 49-152/350.0
RKNRYANVLPYDVTRVRLS--------MQVGVEGSDYINANYIDGY----MAKRTF--IATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHR
 |||| |.|||. .||.|         ..  ....|||||||.         .  |  ||||||.|.|. ||.... . .   |..|...||.   |..|
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPG
||. 
YWqe

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 335-423 7.1e-15 49.2 In-house 50-154 (349) alignment
Range on Protein: 335-423
Range on HMM: 50-154/349.0
RKNRYANVLPYDVTRVRLSMQV--------------GVEGSDYINANYID--GYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKM
 |||| ..|||. .||.|   .              .    |||||||.    . ... .||||||.| |. ||....  ..   .. | .. |..  |.
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

HRYWP
..|| 
diywq

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 336-568 2.3e-18 61.3 In-house 22-257 (290) alignment
Range on Protein: 336-568
Range on HMM: 22-257/290.0
KNRYANVLpYDVTRVRLSMQVGVEGSDYINANYIDgYMAKRTFIATQAPIPET-------IPDFWRMVWEQNCCTIVTLAQEVEQAKAKMH----RYWPG
..|... |    ||| |        .||| ||..  .     .|.||.|  ..       | .|| |. . .   .| | .  |. . . .    .| | 
dqRlevpL.veatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpe

KQP--ITFGSLVVEMQDKVKSGHLVVRIFKLTNTEvSASRDVRQFHYTSWTEENPLEDGLSRCQLIDLIgqvQywqaeSGRHPIIVHCSAGVGRTGVFCA
.    ..|. | |. ..|.|   . .|   ..  .      |    . .|.. |  || ..  .||. .   .       . |.||||  |. |  .. |
svgeelkfkgltvkCkskekeddvetRelvvkfdd.eeeftvtHsllkgWnklnvqedtktllsliqkv...k.....asktpvivHcvdGiSrsAalaa

VSILIERLK-AEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLE
. .    .   .  | . . .|.||.||  ..... .. |   ... 
iilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivl

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 343-440 1.5e-09 32.3 In-house 3-89 (130) alignment
Range on Protein: 343-440
Range on HMM: 3-89/130.0
LPYDVTRVRlsmqvgveGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQeVEQAkakmHRYWPGKQPITF--GSLVVEMQDK
|...|.|..        | .||||...      . .. ||.|. .|  |||.|. |.    .| |   ||.       |||  .|. .    ..| . |.
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgs.veee....deywpdsePlewyeediivtltdr





0044763 (Phosphotyrosine protein) phosphatases II 344-569 1.3e-34 114.8 In-house 1-170 (178) alignment
Range on Protein: 344-569
Range on HMM: 1-170/178.0
PYDVTRVRLSMQVGVEGSDYINANYIDGYmakrtFIATQAPIpetiPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQPitfgslvvemqdkvks
|.| ||| ||.  |.|.||||||..|...     ......|     .|......|... .||.|..|.|  . |...||| .                  
pldrtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag................

ghlvvrifkltntevsasrdvRQFHYTSWTEENPLEdglSRCQLIDLIGQVQYWQAESGrHPIIVHCSAGVGRTGVFCAVSILIERlkaeaMVDVFQTVK
                      |.... .   .. .   .. .. ...  .. ...|.| .|..|||||||||.|...|  .....      ..... ..
.....................iqylhipipDhgvpd...llehflefvefieealdekg.gpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaie

QLREQRPaMVQTKGQYDFCYQVVLEY
..||.|| .|.. ||. ..|.. |..
lvrerRp.ivpnpgqlrqLyefelrl

0046846 (Phosphotyrosine protein) phosphatases II 352-571 1.6e-42 140.6 In-house 3-174 (176) alignment
Range on Protein: 352-571
Range on HMM: 3-174/176.0
LSMQVGVEGSDYINANYIDGYMakrtFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQPITFgslvvemqdkvksghlvvrif
| . .  ...||||||.|.|..    .||||.|.|.|..||..|..|... ..|.| .||| .. |...|||  .   .                     
lrllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.....................

kltntevsasrdvrQFHYTSWTEENPLEDglsrCQLIDLIGQVQYWQAESgrHPIIVHCSAGVGRTGVFCAVSilieRLKAEAMVDVFQTVKQLREQRP-
              |.... | . .. ..     .|..|. ... .. |   .|..||||||.||||...|       |. |  ..|.......||||| 
..............qylhlpwpDhgvpdl....elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRpl

AMVQTKGQYDFCYQVVLEYLA
 .||| .|| |.|...|..| 
gavqtpeQyrflyefellllk

0051429 (Phosphotyrosine protein) phosphatases II 359-572 2.1e-53 177.0 In-house 2-227 (272) alignment
Range on Protein: 359-572
Range on HMM: 2-227/272.0
EGSDYINANYIDGYMA---KRTFIATQAPIPETIPDFWRMvWEQNCCTIVTLAQEVEQAKAKMHRYWP------------GKQPITFGSLVVEMQDKVKS
. |.||||....||     .........| | |. ||||. .|... |||.| .|.|... | .||||            . ..|..| |.| .. ..  
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

GHLVVRIFKLTNT-EVSASRDVRQFHYTSWTEENPLEDGlsRCQLIDLIGQvqywqaesgRHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVD-----
 . ..| . ||..   ...| |...|||.|   .  ..    ..|..|. .          .|..||||||..|||...|. .|.... .|..||     
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYllt

---VFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLAS
   ....|..||.|||..||| .|| |.|...||.| |
nlyleeaveelraqrpgavqteeqylflyeallellrs

0043147 (Phosphotyrosine protein) phosphatases II 359-564 8.7e-43 141.3 In-house 3-155 (172) alignment
Range on Protein: 359-564
Range on HMM: 3-155/172.0
EGSDYINANYIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEveqakakmhrywpgkqpitfgslvvemqdkvksghlvvrifklTNTEV
||||||||.|.|.|   . |||||.| ..|..|||||..|... .||.| ..                                           ...  
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

SASRDVRQFHYTSWTEENPLedglSRCQLIDLIGQVQYWQAESGRHPIIVHCSAGVGRTGVFCAVSILIerlkaeAMVDVFQTVKQLREQRPAMVQTKGQ
  .| . |..|..|   ..     .  .|.... ... ..|.|  .|..|||||||||||...|  ...        ......|...||.|| .||...|
llerlgiqylylpwpDhgvp....llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsq

YDFCYQ
| |.|.
yrflyy

0036282 (Phosphotyrosine protein) phosphatases II 360-564 1.1e-46 154.0 In-house 1-164 (174) alignment
Range on Protein: 360-564
Range on HMM: 1-164/174.0
GSDYINANYIDGYMAKRTFIATQAPIPetipdFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGkqpitfgslvvemqdkvksghlvvrifkltnTEVS
|||||||...|...  . .||.|.| .     ||.|..|... |.|.| .|.|  . |...|||                                .  .
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lred

ASRDVRQFHYTSWTEENPLEDGLsrcqLIDLIGQVQYWQAESGRHPIIVHCSAGVGRTGVFCAVSILIERLKaEAMVDVFQTVKQLREQRPAMVQTKGQY
 .| . |..|. |   .. ..      |.... .|. ...|.. .|..|||||||||||...|  ... .|. | .||....|..|| ||| |||| .||
lerlgiqylylpwpDhgvpdlsi....llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQy

DFCYQ
 |.|.
rflyy

0051082 (Phosphotyrosine protein) phosphatases II 360-567 2e-35 117.0 In-house 2-150 (151) alignment
Range on Protein: 360-567
Range on HMM: 2-150/151.0
GSDYINANYIDGYmakrtFIATQAPipetIPDFWRMVWEQNCCTIVTLAQEVEQAkaKMHRYWPGKQpitfgslvvemqdkvksghlvvrifkltntevs
 |||||..|..|.     ......|     .||.....|... |||.| .|.| .  ....|.|  .                                 
lsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

asRDVRQFHYTSWTEENpledglsRCQLIDLIGQVQYWQAESGRHPIIVHCSAGVGRTGVFCAVSILIERlkaeamVDVFQTVKQLREQRPAMVQTKGQY
  ..|.......|.. .         ...| . ..  . .. . .|..||||||.||||...|. .....      |.........|..|| .||.. |.
..ievlhipildwpdpg.......lplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqf

DFCYQVVL
 |.....|
lfqlfall

0049260 (Phosphotyrosine protein) phosphatases II 368-564 3.8e-38 125.9 In-house 1-144 (152) alignment
Range on Protein: 368-564
Range on HMM: 1-144/152.0
YIDGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWpgkqpitfgslvvemqdkvksghlvvrifkltntevsasrdvrQF
.||||. .. |||||.| |.|..|||||..|... |||.| ...| .| |...|.                                           |.
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

HYTSWTEENPLEDGLSRCQLIDLIGQVqywqAESGRHPIIVHCSAGVGRTGVFCAVSILIerlkaeAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQ
... |   .. ..     .|...| .     |..  .|..|||||||||||...|  ...        |.....|...||.|| .|...||. |.|.
lhlpwpDhgvpdlsqlllflllfiekl....aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 370-472 1.8e-12 41.3 In-house 230-328 (440) alignment
Range on Protein: 370-472
Range on HMM: 230-328/440.0
DGYMAKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAkakMHRYWPGK-QPITFGSLVVEMQDKVKSGHLVVRIFKLTNTEvsASRDVRQFH
.||  | .||||| |.  |. ||||.| . .  ||. | |  ...      ||| . . .||| . |  .   .   . || ..|   |     ..||| 
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndkt...csiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkyke..evheirqfe

YTSW
  .|
vqtw

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 374-565 8.7e-27 88.6 In-house 3-199 (199) alignment
Range on Protein: 374-565
Range on HMM: 3-199/199.0
AKRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQPIT--FGSLVVEMQDKVKSGHLVVRIFKLTN--TEVSASRDVRQFHY
..| .|||| |. ||. |||.||||     || . ..  . .| .  |||  .  |  .||| |  .  .     ..  . |||  |   ..|.. .. .
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TSWTEENPLEDGLSRCQLIDLIGQVQYWQAEsGRHPIIVHCSAGVGRTGVFCAVSILIERLK--AEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQV
||| |    .  |    ..      . .. |    |.||||| | | |||| |. | .   .    ..||.|.  |.||. |  .. .  .|.| |||
tswkekttpnvalfvgfvvasrevskkyeqe.kdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 375-565 1e-26 88.4 In-house 3-198 (198) alignment
Range on Protein: 375-565
Range on HMM: 3-198/198.0
KRTFIATQAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQPIT--FGSLVVEMQDKVKSGHLVVRIFKLTN--TEVSASRDVRQFHYT
.| .|||| |. ||. |||.||||     || . ..  . .| .  |||  .  |  .||| |  .  .     ..  . |||  |   ..|.. .. .|
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWTEENPLEDGLSRCQLIDLIGQVQYWQAEsGRHPIIVHCSAGVGRTGVFCAVSILIERLK--AEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQV
|| |    .  |    ..      . .. |    |.||||| | | |||| |. | .   .    ..||.|.  |.||. |  .. .  .|.| |||
swkekttpnvalfvgfvvasrevskkyeqe.kdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 382-560 4.3e-12 40.1 In-house 97-278 (302) alignment
Range on Protein: 382-560
Range on HMM: 97-278/302.0
QAPIPETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGK--QPITFGSLVVEMQ---DKVK----SGHLVVRIFKLTNTEVS--ASRDVRQFHYT
  |  .|.  .| .. . | . .| |.. ||. . |.  |.  |  . ..||   |.     ....      ....   ...|...     . |  ....
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

SWTEENPLEDGLSRcqlIDLIgqvQYwqAESGRHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYD
.| .    ..  .    .|..   ..   || .. ..||||||||||| . |.   |.  . . . |. . |. .|. |   ||.. |  
awpdhGapkeayta...ldil...kf..cesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqli

subfamily_hpo-7_pd Subfamily hpo-7 387-570 2.6e-12 41.2 In-house 45-227 (263) alignment
Range on Protein: 387-570
Range on HMM: 45-227/263.0
ETIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQ--PITFGSLVVEMQdKVKSgHLVVRIFKLTN--TEVSASRDVRQFHYTSWTEENPLEDGL
.||. |....  ..  ..| |.   |... |  .|.| ..     .  . |    ||.|  ....  .|..   |    ..|... |. | |.|  |.  
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvctt.kvqs.dvllktlellstlgeKkkthtvkhysykgWiekndpelar

SRCQLIDLIgqvqywqAESgrHPIIVHCSAGVGRTGVFCAVSILIE----RLKAEA--MVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
.  .....         .|  ....||||.|.||.  |  . ..       |.      .|  . ...||..|.. ..|  |  |   .||...
eilnilkva.......rns..kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfv

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 388-570 2.7e-13 44.6 In-house 40-221 (255) alignment
Range on Protein: 388-570
Range on HMM: 40-221/255.0
TIPDFWRMVWEQNCCTIVTLAQEVEQAKAKMHRYWPGKQP--ITFGSLVVEMQDkvKSGHLVVRIFKLTNT--EVSASRDVRQFHYTSWTEENPLEDGLS
|.  |....  ..  ..| |.   |... | ..|.| ..     .  . |   .   | . |.|  ..| |  |    ..|. ..|. | |.|  |.   
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

RCQLIDLIgqvqywqAESgrHPIIVHCSAGVGRTGVFCAVSILIE----RLKAE--AMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
  ... ..        .|  ....||||.|.||.  |  . ..       |.    . .|  . ...||..|.. ..|  |  |.  .||...
ilnilkvv.......rds..ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv

0048179 (Phosphotyrosine protein) phosphatases II 397-564 2.2e-20 68.3 In-house 26-139 (144) alignment
Range on Protein: 397-564
Range on HMM: 26-139/144.0
WEQNCCTIVTLAQEVEQAKAKMHrywpgkqpitfgslvvemqdkvksghlvvrifkltntevsasrdVRQFHYTSWTEENPLEDGLSRCQLIDLIGQVqy
....  |...|. | |..  . .                                            . |.....|   .. ..    ......| ..  
kklgittvinlteeyepeflere............................................giqylhlpwpDhgvpdllellleflefieea..

wQAeSGrHPIIVHCSAGVGRTGVFCAVSILIerlkAEAmVDVFQTVKQLREQRPAMVQTKGQYDFCYQ
 .. .| .|..|||||||||||...|  ...     .  ..........|..|| .|.. ||. |...
.le.eg.gpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfLle

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 413-568 5.5e-09 29.9 In-house 144-300 (332) alignment
Range on Protein: 413-568
Range on HMM: 144-300/332.0
QAKAKM-HRYWPGKQP-ITFGSLVVEMQDKVKSGHLvvRIFKLTNTEVSASRDVRQFHYTSWTEENPLEDGLSR-CQLIDLIGQVQYWQAESGRHPIIVH
. |||. ...|| |.    | .| ..  |     |.  . |.|| ||    ..   .|.  |.. . | . .      | |       ..     ||.. 
elkakicrkfwpekrskkdfpalsiqasddhsethm..ktfnltvtekkqdhqtvlmhfyewadasklpeymldmrasiklqyirsskktgvcigpimlv

CSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLE
|..|| .  ..... |.. |.  |  | . .|.  .. ||   ..| | |  . .....
catgvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpystacemlmk

0048076 (Phosphotyrosine protein) phosphatases II 428-569 5.7e-22 73.4 In-house 11-142 (145) alignment
Range on Protein: 428-569
Range on HMM: 11-142/145.0
ITFGSLVVEMQDKVKSGHLVVRIFKLTNTEVSASRDVRQFHYTSWTEENPLEDGlsrCQLIDLIGQVQYWQAESgrHPIIVHCSAGVGRTGVFCAVSILI
. .||| . .. .    . . ... ||...   .| . |..|..|   .. ..     .|.... ... ...|   .|..|||||||||||...|  ...
lylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdll...ellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylml

ErlkaeAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEY
.       |.........|.||| .|.. ||. |.|...||.
l.....lgvsleealelvrsqrpgavpnpgqlrflyefelel

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 460-570 1.3e-19 64.9 In-house 87-194 (440) alignment
Range on Protein: 460-570
Range on HMM: 87-194/440.0
ASRDVRQFHYTSWTEENPLEdglSRCQLIDLIGQVQYWQAESGRHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQY
 || ..|.|| .| ..   .       .. .| .|.  | ..|  |..||||||.|||||  ||  ..   |    .|.|  .. .|..|| ||||  ||
esrtlkqyhyqgwpdkgvpk...fagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqy

DFCYQVVLEYL
 | ...||| |
afvheavlegl

PTPc_DSPc_SM00012 464-568 1.7e-33 110.3 In-house 2-105 (105) alignment
Range on Protein: 464-568
Range on HMM: 2-105/105.0
VRQFHYTSWTEENPLEDGlsrCQLIDLIGQVQYWQAESG-RHPIIVHCSAGVGRTGVFCAVSILIERLKAE-AMVDVFQTVKQLREQRPAMVQTKGQYDF
|...|||.|....  |..     ...|. .|. .. .|. ..|..|||||||||||.|.|..||...|..|   ||.||.||.||.||| ||||. || |
vkhyhytgwpdhgvPees...dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylf

CYQVVLE
.|...||
lyralle

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 464-570 9.7e-18 59.0 In-house 217-344 (350) alignment
Range on Protein: 464-570
Range on HMM: 217-344/350.0
VRQFHYTSWTEE----NPLE--DGLS-RCQLIDLIGQVQYWQAESgRHPIIVHCSAGVGRTGVFCAVSILIE-------------RLKAEAMV--DVFQT
| |...  | .     || .    |  . .|||     .. . .    ||.|||||||||||.....  |..             .|.  |..   ....
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnar.sspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

VKQLREQRPAMVQTKGQYDFCYQVVLEYL
|..||.||  |||.. |. |.|. .| | 
vnelrkqrismvqnldqfifiYeallfyf

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 485-571 8.6e-14 45.6 In-house 248-345 (349) alignment
Range on Protein: 485-571
Range on HMM: 248-345/349.0
CQLIDLIGQVQYWQAESgRHPIIVHCSAGVGRTGVFCAVSILIE----------RLKAEAMV--DVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLA
 .|||     .|....    ...|||||| |||||.. . .|..          ..| .|.    .. .| .|| || .|||   |....|. .|.|.|
ndliddlfarlyldtdq.lstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyfa

0038934 (Phosphotyrosine protein) phosphatases II 486-565 4.2e-10 35.1 In-house 98-172 (194) alignment
Range on Protein: 486-565
Range on HMM: 98-172/194.0
QLIDLIGQVQYWQAESGRHPIIVHCSAGVGRTGVFCAVsILIERLKAeamvDVFQTVKQLREQRPAMVQTKGQYDFCYQV
.| . .  |. . .|.  . . ||| ||.||||...|   ||.||.     .. . .. .|| || .... ....  .. 
illrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa.YLiyrlgm....saeeAialfrekRpgaipnqdyleallkr

subfamily_PTEN_pd Subfamily PTEN 487-558 4.2e-08 28.4 In-house 97-168 (184) alignment
Range on Protein: 487-558
Range on HMM: 97-168/184.0
L-IDLIGQVQYWQAESGRHPIIVHCSAGVGRTGVFCaVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQ
|  ... ... | .|. .. ..||| || |||||   |. |...|. | . .. .  .. | .    |.   |
lleeivediekwleedkknvvvvHCkaGkGRtGvli.vayllkslllekaeealelfaeaRtknkkgvtiPsq

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 487-571 6.4e-06 19.0 In-house 227-310 (346) alignment
Range on Protein: 487-571
Range on HMM: 227-310/346.0
LIDLIGQVQYWQAeSGRHPIIVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLA
.| .| |    .       . |    | ||.  |      |..|      .... .|....|||  |..  ||   | .|..|.|
iikmihqflsekq.vqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyia

PTEN_1 489-554 4e-07 25.0 In-house 115-177 (196) alignment
Range on Protein: 489-554
Range on HMM: 115-177/196.0
DLIGQVQYWQ-AESGRHPIIVHCSAGVGRTGVFCAvSILIERLKaeamVDVFQTVKQLREQR-PAMVQ
| . ..  |  . . .. ..||| ||.||.|. .| . |... |     .. .... .||.| |....
dicksfiewllsdpngnvVlVHCkaGlgRsGtvva.ayLmykgk....ltadeAlelvrekRppgapn

PTPc_motif_SM00404 494-549 6.4e-06 21.1 In-house 76-121 (140) alignment
Range on Protein: 494-549
Range on HMM: 76-121/140.0
VqywqaESGRHPIIVHCSAGVGRTGVFCAVSILiERLKAEaMVDVFQTVkqlREQR
.     |. .. ..||| ||| |.. .... .. .. . . . .... |   .|.|
a.....ekkggkvlVHCqaGvSRSatliiaYlm.ryrqls.laeayefv...kerR

subfamily_CG42327_pd Subfamily CG42327 501-571 1.5e-17 58.2 In-house 245-316 (319) alignment
Range on Protein: 501-571
Range on HMM: 245-316/319.0
SGRHPIIVHCSAGVGRTGVFCAVSILIERLKAE-AMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYLA
. . |..|||| ||||||.  |  | |..|.     ||. |.| ..|..|   |.|| ||.| |.|. || .
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak

subfamily_PTPDC1_pd Subfamily PTPDC1 505-565 1e-09 33.1 In-house 116-171 (182) alignment
Range on Protein: 505-565
Range on HMM: 116-171/182.0
PIIVHCSAGVGRTGVFCAVSI-LIERLKAEamvdvfQTVKQLREQRPAMVQTKGQYDFCYQV
 . ||| || |||||  |. .   .||.||      ...| .|..||  .||..| ... . 
kvavhChaGlGrtGvliacylvyakrltae......kaiklvrskrpksiqtreqvelvkef

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 507-570 1e-15 51.8 In-house 2-65 (69) alignment
Range on Protein: 507-570
Range on HMM: 2-65/69.0
IVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
.||||.| |||| | |. . . |.|.| .||.|  |. .|  || ||  . .| | .  . | |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 507-570 1.3e-15 51.4 In-house 1-64 (69) alignment
Range on Protein: 507-570
Range on HMM: 1-64/69.0
IVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKGQYDFCYQVVLEYL
.||||.| |||| | |. . . |.|.| .||.|  |. .|  || ||  . .| | .. . | |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal

subfamily_ptpA1_pd Subfamily ptpA1 537-568 2e-06 21.8 In-house 365-396 (418) alignment
Range on Protein: 537-568
Range on HMM: 365-396/418.0
DVFQTVKQLREQRPAMVQTKGQYDFCYQVVLE
..|  | .|||||| |||   || |||. .|.
nlfsivlklreqrpgmvqqleqylfcyktild