Gene NvecPTP-sf6-2 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily NvecPTP-sf6
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP066_AA protein Get Run
NvecP066_AA_4-281 phosphatase_domain Get Run
NvecP066_AA_293-576 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 1-329 3.9e-158 522.6 In-house 4-331 (564) alignment
Range on Protein: 1-329
Range on HMM: 4-331/564.0
PIPVEAFAMHVRRMHMDGDIGFSEEYEMVQPNdETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPE
||||.... ||.......|. |.|||. .... ..|||... .|||| ||||||||||||||| |...||. .||||||..||||... |.||.||||.|
pipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlae

TFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTRNYGALRVTANETFHMSYYVLRTFLVsHMQEEEEPRQVRQYHYTSWPDHGVPAHPAPLLS
|..||||||||| |..|||||.|||.|. ||..|||..|| .|| | || .|. ....|..||| . ......| |.|||.|.||||||||| ....||.
tiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLd

MVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANKLASRIRELR
..|.|...|.|.|||..||||||||||||||..|.||.|. .|.|.|....|...|..|| |||||.||.|||.|..||. ||.|||....| .....|.
lirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLa

EVDPNIGTTYMDLEFERLTR-DERHPTQFK
||... ..|...|||.||.  .| .. .|.
eveedtemtgleleFqrLatakeieleefa

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1-315 2.6e-115 379.9 In-house 4-318 (319) alignment
Range on Protein: 1-315
Range on HMM: 4-318/319.0
PIPVEAFAMHVRRMHMDGDIGFSEEYEMVQPNDETfTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPE
.|.|. .........  |. .. .|.....  ... |.... .. || |||| ||.|||..|| |..|.|| .||||||..||||..  .||| |.|| .
eievqeLkerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlen

TFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTRNYGALRVTANETFHMSYYVLRTFLVSHMQEEEEPRQVRQYHYTSWPDHGVPAHPAPLLS
|..||||||||..| |.||||.| |... |. .|||.    .|| | || .|  ... |. | . . . ..| | |.| ...||.||||.|| .   || 
tiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslld

MVRTVSSAN-PPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANKLASRIREL
... .  .   ...||..||||||||||||||.|| ||.|  .||..||| .|...| .||.|||...|| ||..||.||| .| ||.. ..|  |...|
llkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkql

REVDPNIGTTYMDLEF
.| ... | |... ||
aekvadtgetgleref

subfamily_PTPRB_pd Subfamily PTPRB 1-280 2.6e-111 366.4 In-house 6-285 (293) alignment
Range on Protein: 1-280
Range on HMM: 6-285/293.0
PIPVEAFAMHVRRMHMDGDIGFSEEYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPE
|| .| |. ||..|. | |..||||||...  ... . . . ...|. |||| ||..|||||| |..|..  .|||||||||.|||    |||.||||||
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpe

TFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDR-GTRNYGALRVTANETFHMSYYVLRTFLVSHmqeEEEPRQVRQYHYTSWPDHGVPAHPAPLL
|.|||||||||. | |||||||| |.|. ||..|||.   . .|| ..|| ... ... .|.|......   |.| |.|||||.||||||||| ....||
tvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektktll

SMVRTVSSAN--PPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAV
..|||| .|     ...|..||||||||||||||.|| .||.  .| ..|.||.| ..|..|||.||||.||.|||..... .
dfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll

0051299 (Phosphotyrosine protein) phosphatases II 1-280 5.4e-111 365.9 In-house 4-286 (288) alignment
Range on Protein: 1-280
Range on HMM: 4-286/288.0
PIPVEAFAMHVRRMHMDGDIGFSEEYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPE
.|.|| .. .|......|  |. ||.|..... ...|....|.|.|. |||| .|..|||||| |..|.|| .||||||.||||||.. .||| |||||.
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn

TFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTRNYGALRVTANETFHMSYYVLRTFLVSHMQ---EEEEPRQVRQYHYTSWPDHGVPAHPAP
|..|||||||||.. .|||||.|.|.||.||.||||..|. .|| ..||  .. ....|..||. |....    ..|.|.|...|||.||||||| .| .
tvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspel

LLSMVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAV
||...| | .|.... ||..||||||||||||||.|| .|..  .||..||...|...|..|. ||||..||.|...||.|..
lldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

subfamily_PTPRA_pd Subfamily PTPRA 1-307 1.1e-104 344.9 In-house 13-322 (330) alignment
Range on Protein: 1-307
Range on HMM: 13-322/330.0
PIPVEAFAMHVRRMHMDGDIGFSEEYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPE
|.||| .   .|.   |    | ||.. .   .   |   . .  || |||. ||. ||.||| |...||| ||||||| .||||..   |||.|||. |
plpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkee

TFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTRNYGALRVTANETFHMSYYVLRTFLVS---HMQEEEEPRQVRQYHYTSWPDHGVPAHPAP
| .|||||.||| || |||||.|.|| . || ||||| |.  || .||. ...  .  | .| |||    ....|...|.|||.|.||||| |||..|  
tvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiG

LLSMVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANKLASRIR
.|.... | . |. .|||..||||||||||||||.||..|.|   |. .|||.||...|..|  ||||. ||.||. .| |  . | ||.|.  | ....
mlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlq

ELREVDPNIG
.| .  ... 
klynkitgtd

0043336 (Phosphotyrosine protein) phosphatases II 1-278 4e-101 333.4 In-house 1-275 (278) alignment
Range on Protein: 1-278
Range on HMM: 1-275/278.0
PIPVEAFAMHVRRMHMDGDIGFSEEYEMVQPNDEtFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPE
||.|. .. .........  ....|.| .. ..  .|. ..|.|.|| |||| .|..|||||| |..|.|.| ||||||.|.||||.. .|||.||||||
pisvkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe

TFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPdRGTRNYGALRVTANETFHMSYYVLRTFLVSHMQEEEEpRQVRQYHYTSWPDHGVPAHPAPLLS
|..||||||||.|. .|||||.|.|.|| ||.|||| .|. .|| ..||  .. |...|..||. |..... |. |.|..|||..||||||| ....||.
tvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllld

MVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVE
....| .|...  ||..||||||||||||||.|. .|...  ||..|..  |...|..|  .|||.|||.|...|| |
flkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1-316 1.6e-90 298.2 In-house 5-315 (315) alignment
Range on Protein: 1-316
Range on HMM: 5-315/315.0
PIPVEAFAMHVRRMHMDGDIGFSEEYEMVqPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPE
|||.. .  .| . .     || ..|| . |  . .  . . .  || |||| ||.|||.||| |  ||   .|||.|||.|||||.   .||.|||...
pipldqlityvaqkkastkngfkqdyesi.pggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnva

TFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRgTRNYGALRVTANETFHMSYYVLRTFlvsHMQEEEEPRQVRQYHYTSWPDHGVPAHPAPLLS
. .||||.|.|.  . |||||.| |. .||...||||.    || . ||  .  . . |  ||.    .  ... |.| |.||||||| |||..  ||. 
svkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtl...svvfgdnirevvqlhytswpdmgvpkytiplmn

MVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANKLASRIRELR
..|||   .  ..|...|||||||||||||||||..|..|  |  |||. |....|..|  |||.  || ||.|||.|...|| | .  .    |   | 
lirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydsll

EVDPNIGTTYMDLEFE
   |. |.| .. .||
apspdtgstllqeqfe

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1-317 3.1e-77 254.5 In-house 2-314 (315) alignment
Range on Protein: 1-317
Range on HMM: 2-314/315.0
PIPVEAFAMHVRRMHMdgDIGFSEEYEMVqPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPE
||||  |   | . .      ||||.  . |. ...  . . .. |  |||| ||. .|..|| |  ..   .|||||| || ...   |.|||||||. 
pipvaqfpafvnknrh..talfseefhdl.pdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlka

TFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPD--RGTRNYGALRVTANETFHMSYYVLRTFlvsHMQEEEEPRQVRQYHYTSWPDHGVPAHPAPL
. |||||||...  . |||.|...|  . || |||||    . ..|...|.  ..   .  | | .    ... || |.| |...| |||.||. . . |
svddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl...vtrkseesrtvtqfqftewPdkGvdkqtssl

LSMVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANKLASRIRE
| ... | . | .   ...||||||||||| .|..|......... ..||| ||...|.||  .|||| .| ||.||. | .    | .   ... ....
lklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqd

LREVDPNIGTTYMDLEFER
|.      | . |  |||.
lhtsvdgsgrskmtkefet

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1-319 1.2e-73 243.0 In-house 1-315 (515) alignment
Range on Protein: 1-319
Range on HMM: 1-315/515.0
PIPVEAFAMHVRRMHMDgdIGFSEEYEMVqPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPE
|.|.  |   | .        ||||.  . |  . .    .    |  |||| ||. || .|| |  ..   .|||.|| || ...   |.||||||.. 
plplaqfPafvnknrht..tlfseefhdl.pgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnka

TFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPD--RGTRNYGALRVTANETFHMSYYVLRTFlvsHMQEEEEPRQVRQYHYTSWPDHGVPAHPAPL
. |||||.|...  . |.|.|.|.|  . || .||||    . ..| ..|    .   .  . |..   ..  ... | | |.|.| |||.||| |   |
svddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkl...tvlkgddsrtvtqfhfteWPdkGvpkhtssl

LSMVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANKLASRIRE
| ... | . .   . |.|.|||||||||| .|..||.. .|..  ..||| ||...|.||  .|||. || ||..|. | .    | .   ...  ...
lklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqd

LREVDPNIGTTYMDLEFERLT
|       | . |  ||. | 
lhssgdgrgrskmtkefqtlk

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1-291 6.5e-72 237.2 In-house 9-295 (297) alignment
Range on Protein: 1-291
Range on HMM: 9-295/297.0
PIPVEAFAMHVRRmHMDGDIgFSEEYEMVqPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRsgAFIASQGPLPE
|||.  ||  |..  .. |. ||||.  . |. ....   . .  |  |.||.||. || ||| |  ..   .|||.|| .. |..    .|..| | ..
piplsdfatlvqk.nrhtdv.fseeflcl.peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmka

TFDDFWRMVWEQGSAIIVMLTQLEERGRrKCDQYWPDRGTRNYGALRVTANETFHMSYYVLRTFLVSHMQEeEEPRQVRQYHYTSWPDHGVPA--HPAPL
| .|||.||...  ..||||....|| . || .||.|.|. ..| . |. . . . . .. |.. |.. .     | |.||....|||. |.   . . |
tvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgka.karrvvkqyqfveWPdkaverkdsassl

LSMVRTVSSANPPTAG-PMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANK
| ..  |      .|  |..|||.||||||| ..|.||.. .| .| ..|.||.|...|..|  .|||. || |.. |..||...  |...|. 
lklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasy

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1-311 1.2e-61 203.3 In-house 3-267 (392) alignment
Range on Protein: 1-311
Range on HMM: 3-267/392.0
PIPVEAFAMHVRRMHMDgdIGFSEEYEMVqPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPE
||||  |   | . .      |.||.  . |. . .    . .. |. |||| ||. || .|| |  .. . .|||.|| ||....   |.|||||| . 
pipvaqfpafveknrhs..alffeefhdl.pgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaa

TFDDFWRMVWEQGSAIIVMLTQLEERGrrkcdqywpdrgtrnygalrvtanetfhmsyyvlrtflvshmqEEEEPRQVRQYHYTSWPDHGVPAHPAPLLS
..|||||||...  . |.|.|.|.|                                               .. | | |.|.| |||..|| | . || 
slddfwrmvfqenvttiamvtklkegd...........................................kgddartvaqfhftewPdkdvpkhtssllk

MVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANKLASRIRELR
... |..     . |.|.||||||||||  |..||.. .| .   .||| || ..|.||  ||||. || ||. |..| ..   | .   ... ....| 
fikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdls

EVDPNIGTTYM
      ... .
tssdGdvrskq

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1-96 3.6e-16 53.1 In-house 4-95 (95) alignment
Range on Protein: 1-96
Range on HMM: 4-95/95.0
PIPVEAFAMHVRRMHMDGDIGFSEEYEMVQPNDeTFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPlegVLESDYINANYIDGYNRSGAFIASQG
|| |  |  ||  || . |  | .|.  ..      ..      ||  |||. ||. || .|| ||      .|||||| ..||| |  ..||.||
pihvsvfhshvlemhsnsdqefdnefksismts.gapytvgsseanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaqg

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 2-318 2.1e-163 537.9 In-house 2-318 (318) alignment
Range on Protein: 2-318
Range on HMM: 2-318/318.0
IPVEAFAMHVRRMHMDGDIGFSEEYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPET
|.||....||||....|.. .|||||......||.|...||.|.||.|||||||.||||.||.|..|||. .||||||||||||.|. |.||.|.|||||
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

FDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTRNYGALRVTANETFHMSYYVLRTFLVSHmQEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSM
..|||||||||.||.||||||.||||..|...|||..|.|.||.|.|...|....|.||||.| |.. .|||| |||||||||||||.|||...| ||..
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtr.teeeesrqvrqyhytsWpdegvpesgaslldl

VRTVSSAN-PPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANKLASRIRELR
||.||.|. ...|||..|||||||||||.||..|..|.|...|...|||..|.|.|..||||||||.||.||.|.|.||...| |||||..|.|||||||
vrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelr

EVDPNIGTTYMDLEFERL
|.||..|||.||.||.||
eqdpesgttemdaefqrl

subfamily_PTPRG_pd Subfamily PTPRG 2-310 7.7e-125 412.2 In-house 1-313 (563) alignment
Range on Protein: 2-310
Range on HMM: 1-313/563.0
IPVEAFAMHVRRMHMDGDIGFSEEYE--MVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLES-DYINANYIDGYNRSGAFIASQGPL
.||. || ||  .| |||||||||.|  . . ...... .|| .| || |||| ||||||.||| |.|| |. .. |||||||||||..| ||||.||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

PETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTRNYGALRVTANETFHMSYYVLRTFLVSHMQ-----EEEEPRQVRQYHYTSWPDHGVPA
..||||||||.||| .|||||.|.|.||||||||.|||  .. .||||.||  |. ....|  ||. . ...     . .. ..|||||||.||||||| 
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe

HPAPLLSMVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANKla
|..| |..|.  | ||. .|||..||||||||||||.| ||..|..  || ...||||....| .|| .|||| ||.|.||||.||.  . ||. |..  
hslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeq..

srIRELREVDPNIGTTY
  ..||... | .   |
..veelknctpyleqqy

0039614 (Phosphotyrosine protein) phosphatases II 2-284 1e-99 329.0 In-house 14-293 (297) alignment
Range on Protein: 2-284
Range on HMM: 14-293/297.0
IPVEAFAMHVRRMHMDGDIGFSEEYEMVQPNDETftWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGV-LESDYINANYIDGYNR-SGAFIASQGPLP
||...............  .. .|.|... . .   . ..|.|.|| |||| .|..|||||| |.|..|| |.||||||.|.|||.. . .|||.|||||
iplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlp

ETFDDFWRMVWEQGSAIIVMLTQLEERGRrKCDQYWPDRGTrNYGALRVTANETFHMSYYVLRTFLVSHmqeEEEPRQVRQYHYTSWPDHGVPAHPAPLL
||..||||||||||. .|||||.|.|.|| ||.||||..|. .|| ..||  ...| ..|..||. |..   ..|.|.|....||.||||||| ... ||
etvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslelll

SMVRTVSSANP--PTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGV
.... | .|.   |  ||..||||||||||||||... ||..   ||..||.  |...|..|. .|||.|||.|..|||.| . ...
eflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl

0045450 (Phosphotyrosine protein) phosphatases II 2-280 4e-97 320.9 In-house 9-304 (307) alignment
Range on Protein: 2-280
Range on HMM: 9-304/307.0
IPVEAFAMHVRRMHMDGDIGFSEEYEMVQPNDE--TFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGV-LESDYINANYI--------DGYNRSGA
|... . ..|.... |.  |. .|.|....      ... ..|.|.|| |||| .|..|||.|| |..|.|   .||||||.|.        |||... .
idalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrk

FIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTR-NYGALRVTANETFHMSYYVLRTFLVSHMQEEEEPRQVRQYHYTSWPDH
||| |||||||..|||||.||||. .|||||.|.|.||.||.||||| |.  .|| ..||  .. |...|..||. |.......|.|.|...|||.||||
fIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdh

GVPAHPAPLLSMVRTVSSANP--PTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGT---IDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAV
||| ....||.... | .|.   |  ||..||||||||||||||... ||..  .|||   .|..  |...|..|  .||...||.|...|| | .
gvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 2-300 4.7e-97 319.8 In-house 4-303 (305) alignment
Range on Protein: 2-300
Range on HMM: 4-303/305.0
IPVEAFAMHVRRMHMDGDIGFSEEYEMVQPNDETFTWHHslHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPET
| .. .|.... .... | |. ..|.... ..|..  ..  . ||| |||...|. .|..|. ||. | . .||||||.|.|||.|. ..|..||||..|
ialddlaayikearvysdkgleaqykslyeeeesidvgk..keankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlknt

FDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTR--NYGALRVTANETFHMSYYVLRTFLVSHMQEEEEPRQVRQYHYTSWPDHGVPAHPAPLL
 .||||...|     |||||.| | |. || ||||.. |.  ..| . |. ... ..| |. | . .|  .|..| |.| ||. |.|||||||  .. ||
vadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsll

SMVRTVSSANPPTAG-PMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANKLASRIRE
|... |  .     | |..|||||||||||.||..| .|.|. .|...|||. ..|.|.||  ||||  ||||.|||| | ..|| |..  . |  |.  
slikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnk

LR
|.
lk

subfamily_Ptp69D_pd Subfamily Ptp69D 2-299 9.7e-94 308.9 In-house 4-305 (307) alignment
Range on Protein: 2-299
Range on HMM: 4-305/307.0
IPVEAFAMHVRRMHMDGDIGFSEEYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPET
|...  .  ..  . | | |. .|||... .    . . | .  |. |||| .|.|.|. || |....|  .||||||..| ||. .  |||.|.|. .|
iaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveat

FDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTRNYGALRVTANETFHMSYYVLRTFLVSHMQ----EEEEPRQVRQYHYTSWPDHGVPAHPAP
 .|||||..|| . .||||..|.|  |.||..|||.  . .|| . |.  .. ..|.|. |.. ||...    |.|. |.| |||||.|.|  || ..  
igDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevarg

LLSMVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANKLASRIR
|| ... | . .    .|..|||||||||.|.|..|||.||.  .| ..|.| .|...|..|||.||   ||||.. ||..    | |..| ..|...|.
llklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaie

EL
.|
rl

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 2-280 1.7e-79 261.7 In-house 2-283 (290) alignment
Range on Protein: 2-280
Range on HMM: 2-283/290.0
IPVEAFAMHVRRMHMDGDIGFSEEYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLE--SDYINANYIDGYNRSGAFIASQGPLP
|||. |. .|   |. |. || ....|..  .. .| .. | . || .||.|||| ||  |. | |. |  .   .|||| ||.||. . ..|| |||..
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

ETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTRNYGALRVTANETFHMSYYVLRTFLVSHMQEEEEPRQVRQYHYTSWPDHG-VPAHPAPL
.|  |||...|.. ..||||||.  | |. || |||||..|..||  ... ..  ....|. |.. | ..........| ||. |.|...| |... . |
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtil

LSMVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAV
|.. . .     .. ....||||..|||...|....  .... .|| ||||  ....| ..  .|||. || .|.. .....
lvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 2-288 4.7e-79 260.3 In-house 2-286 (287) alignment
Range on Protein: 2-288
Range on HMM: 2-286/287.0
IPVEAFAMHVRRMHMDGDIGFSEEYEMVQP-NDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTplegVLESDYINANYIDGYNRSGAFIASQGPLPE
|||| |.  |.. |  |. ||.. . ...  ...     |.. . || |||...|. .|  ||||       . ||||| .||||. . |||....|. .
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfn

TFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTRNYGALRVTANETFHMSYYVLRTFLVSHMQEEEEPRQVRQYHYTSWPDHG-VPAHPAPLL
|  .||......   .||||.|..|  ...| ||||.  .  .|  ...  .  ... |. |.. | . .......||.||..|.|...| |. . . ||
tarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtill

SMVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVD
 . . . .   .. ....||||..|||...|.  .  .... .||.||||  ....| ..  .||| .|| || |...| . .. | .|
vieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysd

0040438 (Phosphotyrosine protein) phosphatases II 4-318 2.7e-107 354.0 In-house 2-314 (317) alignment
Range on Protein: 4-318
Range on HMM: 2-314/317.0
VEAFAMHVRRMHMDGDIGFSEEYEMVQPNDETfTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFD
|. .  .. .... .  ...||.|... ..   |. ....|.|| |||| .|. |||||| |.||.|.|.||||||.|.||.|.. .||| |||||.|..
vldlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntve

DFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTRNYGALRVTANETFHMSYYVLRTFLVSHMqEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVR
||||||||||. .|||||.|||.||.||.||||...| .|| ..||  .........|||. |... ...|.|.|...|||.||||||| .| .||....
dFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfle

TVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANKLASRIRELREVD
 | .|...  ||..||||||||||||||... ||..  .||..||.  |...|..|. .|||..||.|..||| | . ...| ..|..|.... .| ...
avrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllkllipl

PNIGTTYMDLEFERL
.. . .... |...|
alddvklkekelkll

0050432 (Phosphotyrosine protein) phosphatases II 4-285 1.2e-104 345.2 In-house 28-304 (308) alignment
Range on Protein: 4-285
Range on HMM: 28-304/308.0
VEAFAMHVRRmhMDGDIGFSEEYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLtpleGvLESDYINANYIDGY--NRSGAFIASQGPLPET
|. .. .. .  ...  ...||.| .. . . ... ..|.|.|| |||| .|..|||||| |    .  .||||||.|.|||  ... .||| |||||.|
vldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPlpnt

FDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDR---GTRNYGALRVTANETFHMSYYVLRTFLVSHMQEEEEpRQVRQYHYTSWPDHGVPAHPAPL
..|||||||||.. .|||||.|.|.|| ||.||||.    |...|| ..||  .. ....|..||. .......|. |.|...|||.||||||| .|..|
vedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdges.rtvthfhytnWpdhgvPpspeil

LSMVRTVSSANPPtaGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVT
|.... | . .|.  ||..||||||||||||||.|| .|..  .||..|||. |...| .|. ||||..||.|...||.| . . .|
ldflelvrkslpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt

subfamily_PTPRK_pd Subfamily PTPRK 4-315 2.9e-102 336.7 In-house 6-312 (314) alignment
Range on Protein: 4-315
Range on HMM: 6-312/314.0
VEAFAMHVRRMHMDGDIGFSEEYEMVQPNdetftWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFD
|.    ..  ..     || |||| .        |  . .  |. |||. .|.|||.||| |....|  .||||||..||.|.|. |||. ||||.||  
vadllqsiallkraegygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvk

DFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTRnYGALRVTANETFHMSYYVLRTFLVSH-MQEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMV
||||.|.....| |||||.| | || || .|||. ..  || ..|.  ||   . .| |.| |..  .  || |.|||.....||||.|| .   ||..|
dfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklv

RTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANKLASRIRELREV
| | . ....||...|||||| |||||||..|..|. . .||..|||  |...|...  ||.|| ||.||.|...||..|| | . . .. .   |  ..
rrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesirl

DPNIGTTYMDLEF
||.  .. .  ||
dpqtnssqlkeef

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 5-316 5.6e-81 267.2 In-house 8-324 (325) alignment
Range on Protein: 5-316
Range on HMM: 8-324/325.0
EAFAMHVRRMHMDGDIGFSEEYEMVqPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDD
  .  || . . . . ||. |.... |.|.. . . . .|.|| |||. |.||.|.||| |  ..   .||||||.|.  . .   |.|.| ||..| .|
vnlvehvekkkaqdqdgfahefgll.psddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatind

FWRMV--WEqgSAIIVMLTQLEErGRRKCDQYWPDR--GTRNYGALRVTANETFHMSYYVLRTFLVSHMQEeEEPRQVRQYHYTSWPDHGVPAHPAPLLS
.||.|  |.  ....|.| .|.. |  .| .|||..   ....|.|.|      ..| || | . |  ...  | | |.|... ||.| ||. .|| |.|
lWrlvldWr..csvvvvlneldl.gkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkk.GetrsvkqfqlqswddmGvqkrpatlis

MVRTVSS------ANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANKLAS
....|        ||  ...|..|||||||||||.||.| |.|..  .|  .|.||||...|..|  ||.|  ||..|..|||||...| |.|  . . .
ilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfea

RIRELREVDPNIGTTYMDLEFE
..  |.| .|      .. |||
klsslqernpltqklniekefe

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 6-291 2.1e-69 229.0 In-house 6-290 (439) alignment
Range on Protein: 6-291
Range on HMM: 6-290/439.0
AFAMHVRRMHMDGDIGFSEEYEMVQPNDETFTWHHSLH--PANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFD
 |  || ... . .  |.|..|...  .  ..   ||     .. |||| ...|.||.|| |  . ||  | |||||||.||     .||.|||  || |
efqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettd

DFWRMVWEQGSAIIVMLTQLEERGRrkcdqYWPDRGTRNYGALRVTANETFHMSYYVLRTFLVSHMQ-EEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMV
||||.|.|. .. |||||.| |  .     |||  .   || . | ..    .  ||.| | |   .   |  | | |.||..|||. |||. . .| ..
dfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldfl

RTVSSANPP-TAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANK
|.. |||     ||..|||||||||||| |.||  |..   |  .|. | |. .|..|. |||.  |||||..|..| .. | . |  ..
rainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtide

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 6-278 2.3e-51 169.2 In-house 16-281 (290) alignment
Range on Protein: 6-278
Range on HMM: 16-281/290.0
AFAMHVRRMHMDgdiGFSEEY-EMVQPNDETFTWHHSLHPANK--YKNRYANIVAYDHSRVLLTplEGvLESDYINANYIDGYNRsgAFIASQGPLPETF
 || .| .. .|   ... || | ..|   .     ..  .|    |||| ..|  | .||.|   .|  . ||. |||..| .    || .||.| .| 
kfasdvvkknvd...elakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilk..dG.ydGdyvhanyvkGlka..mfiltqGalkdtv

DDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTR--NYGALRVTANETFHMSYYVLRTFLVSHMQEEEEPRQVRQYHYTSWPDHGVPAHPAPLLS
 |.|||| ... | |||| .| | |. ||.||.|..  .   .|.. |.  |  .    . .  |    ...    ... ..  ||||. |.     || 
idiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallr

MVRTVSSAnpptAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVE
..|..  |    .||..||||||.||||||....  ||   .   .|. . || .|| |   || . ||. . ..|..
tlrilrka....sGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld

subfamily_PTPN9_pd Subfamily PTPN9 7-278 4e-86 283.7 In-house 6-288 (297) alignment
Range on Protein: 7-278
Range on HMM: 6-288/297.0
FAMHVRRMhmdGDIGFSEEYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFW
.  .|. .   |  | |.||. .. .  . | ..| ..||  ||||.... ||..|| |. ...  .|||||||..|||..  |||| ||||..|..|||
lvayvkek...gkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfW

RMVWEQGSAIIVMLTQLEERGRRKCDQYWP--DRGTRNYGALRVTANETFHMSYYVLRTFLVSHMQEEeEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRT
||||||   .||| |...||||.|| ||||  .  . ..| |.|.  |. ... |. |.. ......| | |.|  . ..||||.|||   | || ....
rmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkte.esrkvthfqflsWPdyGvPssaaslldvlek

VS-------------SANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVE
|              .. .|.  |..||||||.||||||||||  |.|  ..||.||.  |...|..|  ..||. ||.| . |..|
vrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 7-278 2.5e-38 126.4 In-house 1-267 (281) alignment
Range on Protein: 7-278
Range on HMM: 1-267/281.0
FAMHVRRMHMDGdigFSEEYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTP-LEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDF
|||  ..| .|    | .|.  .  .  .       .| |. ||||.|| . | ||| |   .     .||| ||||        .| .|||  ||  ||
famssqkmtldd...fkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradf

WRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGT--RNYGALRVTANETFHmSYYVLRTFLvsHMQEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVR
|||.|.. .. |||| |. |  | || .|.|       ..  | |. ...      .. | |   .  | | | . .. .  |||  ||     .| ..|
wrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstv.nkslvttrl..nlsyegetrlithwlwkewpdwqvpessevmlkilr

TVSSAnpptAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTI-DVFGFVRQMRN-KRNLMVQTESQYVFIHDALVE
 . .     . | ..||||||||.||.....  ||      |. |.   | ..|   |   |||  ||..|   |..
kirar....stppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 9-279 9.7e-99 325.0 In-house 10-278 (288) alignment
Range on Protein: 9-279
Range on HMM: 10-278/288.0
MHVRRMHMDGDIGFSEEYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRM
 .| ... ..  ||||||. . . ..| . . . .. |. |||| ||..||. || |. || . ..|||||.||||.... ..||.||||..| .|||..
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

VWEQGSAIIVMLTQLEERGRRKCDQYWPDRGT-RNYGALRVTANETFHMSYYVLRTFLVShmqEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSS
|.|. .  |||||.| |.|..||..|||| .. .||| . ||. |. ..  .|||..|.     ... ... ||.|..|||||||.  |||| ..|.|  
vyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkv

ANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEA
||.  .||.|||||||||||||||.|| ....  .| .|||.|.| ..|..|.|.|||..||.||...|.. 
anqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 9-280 1.1e-91 301.8 In-house 4-276 (281) alignment
Range on Protein: 9-280
Range on HMM: 4-276/281.0
MHVRRMHMDGDIGFSEEYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRM
 |..... . . || |||| ..  .   | . | ...|. |||| ||||||..|| .|| |   ..||||||...||.   ..||.|||.|.....||.|
khlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqm

VWEQGSAIIVMLTQLEERGRRKCDQYWPDRG-TRNYGALRVTANETFHMSYYVLRTFLVshMQEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSS
||||   .|||.|.  | |. || .||||   . .|| ..|. ... . . |. |.| .   .|. |.|.|.| .||.|||||||| .. ||.  . | .
vweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlk

-ANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQE-GTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAV
  .. |  |...|||||||||||.|.|| .......|  ..||   |...|..|||||||  || |.. |...|.
ltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 9-281 1.6e-58 192.7 In-house 7-294 (301) alignment
Range on Protein: 9-281
Range on HMM: 7-294/301.0
MHVRRMHMDGdigFSEEYEMVQPNDETFTwHHSLHPANKYKNRYANIVAYDHSRVLLTPLEG--VLESDYINANYIDGYNRSGAFIASQGPLPETFDDFW
.||  .| ..   |.|.|. .. ...  . . .|. .||. ||. ||. ||. |..|.| .   . . .||||.|||||... .|||.|||. .|  |||
thvaakhsnk...feeqykelkegedksc.tvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfW

RMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRG--TRNYGALRVTANETFHMSYYVLRTFLV--------------SHMQEEEEPRQVRQYHYTSWPDHG
|..|..  . |||.|.|.|. . || ||||.    . ..| . || ...  .  .|.| . |               ..... ....| |.. |.||..|
rliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdG

VPAHP-APLLSMVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVI
|   |   | ..   .   . .  ||..||||..|.|.|......  |  .  || .|||. .. .| ..  .|.|  ||..|.|.. . . 
vvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq

subfamily_PTPN23_pd Subfamily PTPN23 10-280 1.2e-64 212.9 In-house 5-280 (288) alignment
Range on Protein: 10-280
Range on HMM: 5-280/288.0
HVRRMHMDGDIGFSEEYEMVQPNDETFTWHHSLHPANKY--KNRYANIVAYDHSRVLLTplegVLESDYINANYIDGY-NRSGAFIASQGPLPETFDDFW
...|  .||  .. .... .. ...  . ..|.  |..|  |||. .|. |||.|| |       . ||||| .. .    .  |||.|.||..|  |||
elqrkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFW

RMVWEQGSAIIVMLTQLEERGRRKCDQYWPDR--GTRNYGALRVTANETFHMSYYVLRTFLVSHMQeEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRT
.||.|| | .||||.. ||.|. |.|.||| .   | ..|.|.|| ... .....| |.. ... . ... ..|.  ..||||..|||| |  || ..  
lmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletld.adavksvshlqltsWpelGvPasPetllqflde

VSS----ANPPTAGPMIVHCSAGVGRTGTFITLDSMLQR-AAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAV
| |     . ..  |..|||||||||||.|  . . ..   ...| .|.   |...|..|  |||...|. |  .| .||.
vesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa

0036941 (Phosphotyrosine protein) phosphatases II 13-294 1.6e-100 331.5 In-house 6-291 (297) alignment
Range on Protein: 13-294
Range on HMM: 6-291/297.0
RMHMDGDIGFSEEYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLtpleGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQ
 .....  ....|.| ..|.   ... ..| |.|. |||| .|..|||.|| |    .  .||||||.|.|||... .||| |||||.|..|||||||||
lekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweq

GSAIIVMLTQLEERGRRKCDQYWPDR--GTRNYGALRVTANETFH--MSYYVLRTFLVSHMqEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSA
.. .|||||.|.|.|| ||.||||.   .. .|| ..||  .. .   ..|.|||. |... ...|.|.|...|||.||||||| .||.||.... | ..
nvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt.gngesrtvthfhytgwpdhgvpespaslldfielvrkv

NP--PTAGPMIVHCSAGVGRTGTFITLDSMLQRAA---QEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANKLAS
..  |  ||..|||||||||.||||..| |||.      ||..|.. .|...|..|. .|||..||.|...|| | . .. | . ..||..
lkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklvl

0047943 (Phosphotyrosine protein) phosphatases II 13-279 6e-99 326.2 In-house 5-271 (273) alignment
Range on Protein: 13-279
Range on HMM: 5-271/273.0
RMHMDGDIGFSEEYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLtpleGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQ
.....|  .. ||.|..... . .|. ..|.|.|| |||| .|..|||||| |    |  .||||||.|.||||.. .||| |||||.|..|||||||||
lekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

GSAIIVMLTQLEERGRRKCDQYWPDRG---TRNYGALRVTANETFHMSYYVLRTFLVSHMQEEEePRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSAN
.. .|||||.|.|.||.||.||||. |   . .|| ..||  .... ..|..||. ..... .| .|.|...|||.|||||||.....||.... | .|.
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkal

PP--TAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEA
      ||..||||||||||||||.|| .|..   ||..||.  |...|..|  ||||..||.|...||.| 
ealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 13-287 3.1e-97 320.4 In-house 20-297 (298) alignment
Range on Protein: 13-287
Range on HMM: 20-297/298.0
RMHMDGDIGFSEEYEMVQPNDE---TFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMV
 ..  . .|...|.. ..   .   ..... . .|.|| |||||.|.|.|.|||.|.  ..  ||||||| ....|... ||||.|.||.||. ||||||
vkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmv

WEQGSAIIVMLTQLEERGRRKCDQYWPDRGTRNYGALRVTANETFHMSYYVLRTFLVSHMQEEeEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSaN
.|. .. |||||.||| .. |. .||||.|...|| ..|.  .. ... .. |.. ||. .|| . |.||| |.|||||.|||..   .| ..| |   .
teedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvra.s

PPTAG--PMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEV
.  ||  |.||.|||||||.|||| .||.|.|. .| ..|||  |. .|.||  .||||.|||||..|  ||. .. .|.
qqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei

subfamily_PTPN6_pd Subfamily PTPN6 16-277 2.2e-87 287.9 In-house 22-294 (306) alignment
Range on Protein: 16-277
Range on HMM: 22-294/306.0
MDGDIGFSEEYEMVQPND--ETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTpLEGVLESDYINANYIDGY--NRSGAFIASQGPLPETFDDFWRMVWE
. .  ||.||.| .| ..  .... ... .| || |||| ||. .||.|| |.  ..| .|||||||||..   . . ..||.|| |..|  |||||||.
slekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwq

QGSAIIVMLTQLEERGRRKCDQYWPDRGT-RNYGALRVTANETFHMSYYVLRTFLVSHMQEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANP
. | .|||.|.  |||. || .||||  . ..|| ..||  .  ....|.||...||......| |.|.|||..||||||||..|  .|.....|.. . 
ensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqe

PTA----GPMIVHCSAGVGRTGTFITLDSMLQRAAQEG---TIDVFGFVRQMRNKRNLMVQTESQYVFIHDALV
 ..    ||..||||||.||||||| .| .|.   ..|    ||.  .|...|. |. .||||.|| |.. |. 
eleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik

0045098 (Phosphotyrosine protein) phosphatases II 20-281 1.4e-89 295.5 In-house 7-273 (278) alignment
Range on Protein: 20-281
Range on HMM: 7-273/278.0
IGFSEEYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLltplegvlesDYINANYIDGYnrSGAFIASQGPLPETFDDFWRMVWEQGSAIIVM
. .. |.| . .     .. ..| . |..|||| .|..||||||           |||||.|||||  . .||| |||||.|..|||||.||.|. .|||
ldlllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivm

LTQLEERGRRKCDQYWPDRGTRNYGALRVTANETFHMSYYVLRTFLVSHM---QEEEEPRQVRQYHYTSWPDHGVPAHP--APLLSMVRTVSSANP----
||.|.|.|| ||.||||..|. .|| ..||  .. ....|.|||.|| .    .|. |.| |...||..||||||| .|  ...|.... . .|.     
ltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllas

---------PTAGPMIVHCSAGVGRTGTFITLDSMLQRAaqEGTIDVFGFVRQMRNKRNL-MVQTESQYVFIHDALVEAVI
         .  ||..||||||||||||.. .. ||..   ||..|..  |...|..|.  .||...||.|....|.| . 
lllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 20-278 3.6e-39 129.3 In-house 22-285 (305) alignment
Range on Protein: 20-278
Range on HMM: 22-285/305.0
IGFSEEYEMVQPNDEtFTWHHSLHPA-NKYKNRYANIVAYDHSRVLLtplEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIV
.|. .|.  ..  .. |   .... | .. |||| ..   |. || |   ||    .|| |||.     .  || .| || .|  ||| | ...    | 
aglraefvamkrfnd.fekmkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaif

MLTQLEERGRRKCDQYWPDRGTRN--Y----GALRVTANETFHMSY------YVLRTFLVSHMQeEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVrtvS
|| .| |.| .|| .|.. .      .      . |  . .  ...       | .| ||      |. |.| .||.  ||| ||||    .| ..    
mlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegp.gekarkvthyhwidwpdrgvpaadlailell...e

SANpPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDV-FGFVRQMRNKRNLMVQTESQYVFIHDALVE
 |  |. ||..||||||.||||. . |. .|..  .   |.     ....|..||  .||. ||.|.|. ...
kar.pskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln

0046845 (Phosphotyrosine protein) phosphatases II 21-286 4.3e-102 336.6 In-house 1-280 (284) alignment
Range on Protein: 21-286
Range on HMM: 1-280/284.0
GFSEEYEMVQPNDETF--TWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGV-LESDYINANYIDGY-----NRSGAFIASQGPLPETFDDFWRMVWEQ
|. ||.|... .  ..  .....|.|.|. |||| .|..|||||| |..|.|   .||||||.|.|||     ... .||| |||||.|..|||||||||
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

GSAIIVMLTQLEERGRRKCDQYWPDRG-TRNYGALRVTANETFHMSYYVLRTFLVSHMQEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANP-
.. .|||||.|.|.|| ||.||||. | . .|| ..||  .. ....|..||. ..... ..|.|.|...|||||||||||..|..||...|.| .... 
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

-PTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEG---TIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTE
 |. ||..||||||||||||||.|| .|..  .||   ..||.. |...|..|. ||||..||.|...||.|.. ...| 
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 21-279 1.5e-46 153.6 In-house 7-258 (267) alignment
Range on Protein: 21-279
Range on HMM: 7-258/267.0
GFSEEYEMVQP-NDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLegvlESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVM
 . .|.|...   |.. |   |.   |. .||. . . ||..|| |       | .|||| |..||..  |||. |.||  |  ||. .. .|. ..||.
eiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtk....eeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivl

LTQLeerGRRKCDQYWPDR--GTRNYGALRVTANETFHMSYYVLRTFLVSHmqEEEEPRQVRQYHYTSWPDHGV-PAHPAPLLSMVRTVSSANppTAGPM
||.    .  .  ..|| .   ...|  | |  .       | . |. .    ..|  ..|  |.|  |        .  ||. ..      |     |.
ltkv...ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkf..knesahnvtlyyykkwnintnnkpylkplfgilaknqlen..gnrPl

IVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEA
.|.||.||||.|||...||.|.|| .||. |.| |.|..|..|  .|.|  .|..||. |.| 
vvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey

DSPc_SM00195 22-279 2.4e-93 307.6 In-house 2-261 (263) alignment
Range on Protein: 22-279
Range on HMM: 2-261/263.0
FSEEYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLT
..||.| .. .... . ... ...|| |||| ||. |||.|| |.. |.  .|||||||||.|.|.. ..|| |||||.|..||||||||... ||||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

QLEERGRRKCDQYWPDR--GTRNYGALRVTANETFHMS-YYVLRTFLVSHMQEeEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPPTAGPMIV
. ||.|..|||.|||.   |. ..| ..|.  |. ...  ..|||. ... .. ||.|.|.||.|..||||||| .. ..|...|.| . .  . ||..|
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEA
||||||||||||.|.|..|.. ..| ..|.|  |...|..|  ||||. || ||..|..|.
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey

PTPc_SM00194 22-279 2.4e-93 307.6 In-house 2-261 (263) alignment
Range on Protein: 22-279
Range on HMM: 2-261/263.0
FSEEYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLT
..||.| .. .... . ... ...|| |||| ||. |||.|| |.. |.  .|||||||||.|.|.. ..|| |||||.|..||||||||... ||||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

QLEERGRRKCDQYWPDR--GTRNYGALRVTANETFHMS-YYVLRTFLVSHMQEeEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPPTAGPMIV
. ||.|..|||.|||.   |. ..| ..|.  |. ...  ..|||. ... .. ||.|.|.||.|..||||||| .. ..|...|.| . .  . ||..|
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEA
||||||||||||.|.|..|.. ..| ..|.|  |...|..|  ||||. || ||..|..|.
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey

subfamily_PTPN1_pd Subfamily PTPN1 23-282 9.5e-61 200.0 In-house 9-275 (290) alignment
Range on Protein: 23-282
Range on HMM: 9-275/290.0
SEEYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGvlesDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQ
.| |. .. . . |. ... .|.|. .||| ..  |||||. |   .     |||||. ..  .    .| .|||||.| | ||.||||| |  .||| .
keiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnk

LEERGRRKCDQYWPDRGT---RNY--GALRVTANETFHMSYYVLRTFLVSHMQEeEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSS--ANPPTAGP
. |... || ||||         .    |.|.  .. . |||..|.. .  ..  .| |.. ..|||.||| |||  || .|...  | .  .  .  ||
vvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlkt.qetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGp

MIVHCSAGVGRTGTFITLDSMLQRAAQEGT---IDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVI--C
 ..|||||.||.|||. .|..| .  ...    .|.   . ..|. |  ..||  |  | . |..| .    
avihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvik

subfamily_PTPN13_pd Subfamily PTPN13 24-279 1.2e-69 229.6 In-house 15-268 (273) alignment
Range on Protein: 24-279
Range on HMM: 15-268/273.0
EEYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGvlesdYINANYIDGY--NRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLT
||.. ..    . | . . . .|| |||| |.. ||..|| |    |     ||||..|     .    .||.||||||| .|||.||||| . .|.|.|
eefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt

QLEERGRRKCDQYWPDRGTRN---YGALRVTANETFHMSYYVLRTFLVSHMQEEeEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPpTAGPMIV
.  |.|. ||..|||..  ..   .. |.|.  .. ... .|.|.. |.... . | |.| . ....|||||||...|.|| .|. | . .   |||..|
lekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesg.esrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivv

HCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEA
|||||.||.||.||.| .|.  ...  .||   ||..|..|. .|||. ||.|.. |..|.
hcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailev

subfamily_PTPN14_pd Subfamily PTPN14 24-278 2.2e-60 199.2 In-house 27-294 (300) alignment
Range on Protein: 24-278
Range on HMM: 27-294/300.0
EEYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVlESDYINANYIDGY--NRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLT
 ||| .... |  . . .  | |. |||. ... |...|| |.| .   ...||||  |      ..  .|..||||. |  |||.|||||| ..|||||
teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlt

QLEERGRRKCDQYWPDR----GTRNYGALRVTANETFHMSYYVLRTFLVSHMQEEEEpRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANP-------
. || |. |. .|.|.      | ..|  .||.. . . . .. ... . |.  .|| |.|    || |||||||  . . || .. | |          
eeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskee.rtvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseve

--PTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVE
   .  |..|||||||||||  |. | ...   .. .||.   ....|..| |.||| .|| |....|..
skeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik

subfamily_PTPN3_pd Subfamily PTPN3 25-279 3e-74 244.4 In-house 20-274 (280) alignment
Range on Protein: 25-279
Range on HMM: 20-274/280.0
EYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLegvlESDYINANYID----GYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVML
..|..   ..  . ...  |.|  |||| .|..||. || |.      |.|||||||..    . . .  .||.||||..|  |||.||||| | .||||
qfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkes....etdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivml

TQLEERGRRKCDQYWPDRG-TRNYGALRVTANETFHMSYYVLRTFLVSHMQEEeEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPPTAGPMIVH
|.| |||| || ||||. . . .|| ..|. ... . . |||| ..... ... | |.. |  |..||||||| ..| .|..|..| ..   .  |..||
ttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketk.eerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvh

CSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEA
||||.|||| .|.|.  |.   ..  . .   ||.||..|  .|||.||| |. .|....
CsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 31-280 7.1e-36 118.7 In-house 29-271 (288) alignment
Range on Protein: 31-280
Range on HMM: 29-271/288.0
PNDETFTWHHSlHPANKYKNRYANIVAYDHSRVLLTplegvLE-SDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRR
||. .    .| . ||  ..|| |.   | .|| |.      .   ||.|| .   .    .| .| ||  | . .|.|. |..   ||||..| |.|..
pneasidiids.fianptrdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGke

KCDQYWPDRGTRNY--GALRVTANETFHMSYYVLRTFLVSHMQEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANpptaGPMIVHCSAGVGRT
| ..|.| .  ..   | |     .       ...  |.   .| ||.  |.. |.  |.|.|||    . | ..  . | .     |..||.|||||||
ksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslq....kPivvhssaGvGrt

GTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAV
||.|    .|. .  .  . .  .. ..|..|   .||| ||...|  . | .
gtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel

subfamily_PTPN12_pd Subfamily PTPN12 32-281 8.6e-82 269.3 In-house 26-278 (290) alignment
Range on Protein: 32-281
Range on HMM: 26-278/290.0
NDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKC
...... ... .. |. |||| .|. ||.||| |.  |.. .|||||||.| | . . ..||.|||||.| ||||||.||.   |.||. .. | |. ||
aekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkC

DQYWPDRGTRN--YGALRVTANETFHMS-YYVLRTFLVSHMqeeEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPPTAGPMIVHCSAGVGRTG
..|||..| ..  .|...|| .|  ...  ...||. | .    .| |.|.|.|||.|||||||. . .||.....| . .   . |..|||||||||||
erYWpeegeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtG

TFITLD---SMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVI
| |..|   ..|..   . ..|||  |...|..|. .|||. ||.... |..| | 
tiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq

subfamily_egg_pd Subfamily egg 32-289 9e-30 98.4 In-house 26-282 (307) alignment
Range on Protein: 32-289
Range on HMM: 26-282/307.0
NDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERgrRKC
  .  . ....   |. | |   .   | ||| |   .|    |.| ||...|      || .| || .| |||||||...    |||||   |    .|
svdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erc

DQYWPDRGT--RN--YGALRVTANETFHMSYYVLRTFLVSHMQEEEEPRQVRQYHYtSWPDHGVPAHPAPLLSMVRTVSSanpptagPMIVHCSAGVGRT
. |||   .       |.||... .  . .  ..|   .  .  ..| | .  . .  .   .    |  .| ..| .|        |..|..  || ..
eyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg.dvnnssdvysplrvlrklrnlsk.......pvvvqdilGvska

GTFITLDSMLQRAAQEGT--IDVFGFVRQMRNKRNLMVQTESQYVFIHDALV---EAVICGVTEVDA
.|.....  |    .  .    |   |  .| .|.| |..  .|.|..  ..     ||  . |.| 
atlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsakeldv

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 33-277 4.5e-59 194.6 In-house 25-274 (287) alignment
Range on Protein: 33-277
Range on HMM: 25-274/287.0
DETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTpLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCD
  |.|.. . . |.  |||||... .|..||||.  || | ||||||||. .|..  ||||.|||.. |  ||||.|.|. || ....|.  | .| || 
sstatfkaaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcy

QYWPDRGT-RNYGALRVTA-NETFHMSYYVLRTFLVSHMQEeEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTV-----SSANPPTAGPMIVHCSAGVG
.|||.|      |   |.. . .     |  |.. . ...  .| | |.|... ||||....     |. .|  |      . .   .||..||...|.|
kywPerevPmrvGGysvvlldydikePeygvralrlidlet.rearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiG

RTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALV
|.|.....  ...|  . | .||   | ..|..|. .||.  |. .. .|||
rsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 33-289 4.7e-39 128.8 In-house 41-298 (310) alignment
Range on Protein: 33-289
Range on HMM: 41-298/310.0
DETFTWHhsLHPANKYKNRYANIVAYDHSRVLLTpLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCD
| ..|..   .  . .||||...|  | ||| |. ..     ||| |||.       .|| |||||  |  |||||.... .  |..| .  | || || 
dssltye..aykkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcv

QYWPDRG-TRNYGALRVTA----NETFHMSYYvLRTFLVSHMQEEEEPRQVRQ-----YHYTSWPDHGVPAHPAPLLSmVRTVSSAnppTAGPMIVHCSA
 |||  | |  || .|||      | | .      ||.   .  .|.| ....      ..  ||| |||      .   | ..       || .|||||
gywpslgvtetygcirvtnlsesseefeicnl.avtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp.qrllaqv...rhgpcvvhcsa

GVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVeAVICGVTEVDA
|..|... ..|.  .... .   .|.   . .....|   .||| ||..|.   . .   | |||  
gkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri.ifargetevae

subfamily_PTPRN_pd Subfamily PTPRN 34-280 9.6e-63 206.6 In-house 44-292 (297) alignment
Range on Protein: 34-280
Range on HMM: 44-292/297.0
ETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYI-DGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCD
|  | . . .. |  |||......|||||| |.      .||||||  | |   |. |.||.||||..|  |||.||||||...||.||.||| | ..|.
epstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqck

QYWPDRGTRNYGALRVT-ANETFHMSYYVLRTFLVSHMQEEeEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPPTAGPMIVHCSAGVGRTGTFI
.|||| |.  |..  |    |      |..|.| .  .| . | | | |.|. |||..|||| . .|| . | |  .    . |..||||.|.||||..|
rywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqts.etrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyi

TLDSMLQRAAQE-GTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAV
 .| .|.| ..    ||.   .  .|..|. .|.|..|. |.  |..| |
lidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev

subfamily_CG7180_pd Subfamily CG7180 35-285 1.2e-63 209.5 In-house 31-295 (296) alignment
Range on Protein: 35-285
Range on HMM: 31-295/296.0
TFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRrKCDQY
. .  . |.  |. |||. ..| ||. ||.|. |.|  .|||||| |.|.. .  ..|  ..|  || |.|||.|.....  .|.||.  .  . .. .|
igdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsy

WPDRGTRNYGALRVTANETFHMSYYVLRTFLVSHM---------QEEEEPRQVRQYHYTSWPD-HGVPAHPAPLLS---MVRTVSSAN--PPTAGPMIVH
|| ..  .|| . |   |. ...  . ||| . ..         |.. | | |.....| |.  . ||   . |.    .||..   .   |. ||..|.
wpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvv

CSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVT
.| |..|.| ....|  |. . .|. .|||..|...|..|. .|..  .| .| | | |||.|...
ssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnkd

0040439 (Phosphotyrosine protein) phosphatases II 37-280 4.7e-90 296.7 In-house 2-246 (249) alignment
Range on Protein: 37-280
Range on HMM: 2-246/249.0
TWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWP
.. ..|.|.|| |||| .|..|||||| |..|.|.  ||||||.|||||... .||| |||||||..|||||.||.|. .|||||.|.|.|| ||.||||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

DRGTRNYGALRVTANETFHMSYYVLRTFLVSHMqEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANP--PTAGPMIVHCSAGVGRTGTFITLD
..|. .|| ..||  .. ....|..||. .... .. |.|.|....||.||||||| ....||.... | .|.   |. ||..||||||||||||||...
lggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaay

SMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAV
 ||..   |...|..  |...|..|. .||...||.|...|| | .
lmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 37-295 2.1e-84 278.6 In-house 52-306 (319) alignment
Range on Protein: 37-295
Range on HMM: 52-306/319.0
TWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTqleergRRKCDQYWP
.  ..  . || |||. ||.|.|...| | .|.|.  |||||| ...|| |   .||.||||..| .|||||.||. .. ||.||      . || ||||
dqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywp

DRGTRNYGALRVTANETFHMSYYVLRTFLVSHMQEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPP--TAGPMIVHCSAGVGRTGTFITLD
 ..  ...   |  .     . ||.| . .|.  .|.. |...|.|.  |||.||| .|..|. .|. |.  .       ...|||||||||||..|.||
lkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivld

SMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANKLASR
 .|.|  .|  .||. |||..|..|| .||   || ||. ||.|  . | ..|    . . 
vlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpay

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 37-295 3.3e-83 274.5 In-house 16-270 (284) alignment
Range on Protein: 37-295
Range on HMM: 16-270/284.0
TWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTqleergRRKCDQYWP
.  ..  . || |||. .|.|.|...| | .| |.  |||||| .| || |   .||.||||..| .|||||.||. .. ||.||      . || ||||
dqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywp

DRGTRNYGALRVTANETFHMSYYVLRTFLVSHMQEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPP--TAGPMIVHCSAGVGRTGTFITLD
 ..  ...  .|  .     . ||.| . .|.  .|.. |..||.|.  |||.||| .|..|. .|. |.  .       ...|||||||||||..|.||
lkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivld

SMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANKLASR
 .|.|  .|  .||. |||..|..|| .||   || ||. ||.|  . | ..|    ... 
vlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpay

0049772 (Phosphotyrosine protein) phosphatases II 37-279 8.5e-47 155.7 In-house 37-279 (314) alignment
Range on Protein: 37-279
Range on HMM: 37-279/314.0
TWHHSLHPANKYKNRYANIVAYDhSRVLLtPLEGVLESDYINANYIDGYnrsGAFIASQGPLPETFDDF----------WRMV--WEQGSAIIVM-----
|.  . ...|. |||| .|. .| .|| | | ..|  ||||||.|.||.    .|||.||||..|..||          ||||  ... . .|||     
tilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdev

----------------LTQLEERGrrkcdqywPDRGTRNYGALRvtanetfhmsyyvlrtflvS-------HmqeeeePRQVRQYHYTSWPDHGVPaHPA
                |..| ..|        .    ...  |.                   .              .|.. .|... .||...|  ..
ladelsrLdaAlgKtpllildgng........neptaadlellk...................eelydpelf......erlgikylripvpDgsap.lle

PLLSMVRTVSSAnpPTAGPMIVHCSAGVGRTGTFITLDSMLQRAaqegTIDVFGFVRQMRNKRN-----LMVQTESQYVFIHDALVEA
 ...... . .|  .. || .|||.||.||||||.... .. .      ...   ....|.||       ....  ||.||..|| |.
dfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealley

0037934 (Phosphotyrosine protein) phosphatases II 38-278 1.2e-83 275.7 In-house 2-240 (243) alignment
Range on Protein: 38-278
Range on HMM: 2-240/243.0
WHHSLHPANKYKNRYANIVAYDHSRVLLtplEGvleSDYINANYIDGYNRsgaFIASQGPLPETFDD----FWRMVWEQGSAIIVMLTQLEERGRRKCDQ
....|.|.|. |||| .|..|||||| |   ||   |||||||.|....|   .||.|||||||..|    ||||.||.|. .|||||.|.|.|| ||.|
fsiallpenlsknrysdilpydhsrvkl...eg...sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPdrGTRNYGALRVTANETFHMSYYVLRTFLVSHMQEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSA--------NPPTAGPMIVHCSAGVG
|||  |. .|| ..||  .. |...|..||.|... ......|.|..|||..||||||| .|..||.... | .         . .. ||..||||||||
ywp..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RTGTFITLDSMLQRAaqegTIDVFGFVRQMRNKRNL-MVQTESQYVFIHDALVE
||||.|... ||..     ..|..  |...|..|.  .|||.|||.|...|| |
RtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 38-140 1.7e-15 51.3 In-house 88-183 (244) alignment
Range on Protein: 38-140
Range on HMM: 88-183/244.0
WHHSLHPANKYKNRYANIVAYDHSRVLLTplEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERgrrkcDQYWPD
 . .. | | .||| .  . .| .|| |.  .| .   |||| ..    |.  .| .| || .|  |||.|. |.   ..|.|  .||      |.||||
mkdafnpnnswknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpd

RGT
   
sep

0042113 (Phosphotyrosine protein) phosphatases II 39-278 5.9e-89 292.9 In-house 2-241 (245) alignment
Range on Protein: 39-278
Range on HMM: 2-241/245.0
HHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDR
 ..|.|.|| |||| .|..|||.|| |.| .| | ||||||.|.|||.... |||.|||||||..|||||.||.|. .|||||..||.|| ||.||||..
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

GTRNYGALRVTANETFHMSYYVLRTFLVSHMqEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANP-PTAGPMIVHCSAGVGRTGTFITLDSML
.. .|| ..||  .. |...|..||. |...  . |.|.|..|||..||||||| ... ||.... | .|   .  ||..||||||||||||||... ||
esltygdftvtllseehlddytvrtlevtnl.gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylml

QRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVE
...  |......  |...|..|  .|||.|||.|...|| |
eqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 39-279 1.6e-46 153.6 In-house 26-294 (297) alignment
Range on Protein: 39-279
Range on HMM: 26-294/297.0
HHSLHPANKYKNRYANIVAYDHSRVLLtpLEGVLESDYINANYIDGYNRS--GAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWP
  .  ..   |||| .|.|.| .|| |  | .. |.|||||.|.   .      .| .|||| .| ||||..|.||.  .|||...|.| || ||  |||
ssakrnsslrknryrdilatddtrvkl..lrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywp

DRGTRNYGALRVTANETFHMSYYVLRTFLvSH--MQEEEEPRQVRQYHYTSWPDHGVPAH----------------PAP-LLSMVR--------TV--SS
.    .  |  |  .   ..|    | .| .   .   .| |.||   . ||||||||.                   | .|..|          .    
svvqerlkagdvvveflsstsdefdrvil.telqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslr

ANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEA
|. |   ...|||||||||.|  .  | .|..  ..   ||  .....|..|  .|||  |. ...|| .. 
aemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkk

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 40-85 8.4e-13 42.4 In-house 41-86 (440) alignment
Range on Protein: 40-85
Range on HMM: 41-86/440.0
HSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGY
 .  | || |||| ||.|||||||.|  ..|| .|||||| ||.| 
iaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi

subfamily_CG42327_pd Subfamily CG42327 42-207 2.4e-35 116.8 In-house 24-192 (319) alignment
Range on Protein: 42-207
Range on HMM: 24-192/319.0
LHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSG-AFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDR--
. .. | |.|..|.|   ..|| |       .. |..|.|. ||. .   .||.| .| ..  ||||.|||| | .|| ||.| | | ..| .|.| .  
vPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtket

--GTRNYGALRVTANETFHMSYYVLRTFLVSHMqEEEEPRQVRQYHYtSWPDHGVPAHPAPLLSMVRTVSS
  .|. || ..||  .      |.. |.|. .. ..|| |..  | |  |.. .|||..|.|..|.  | |
ldntslyGdilvtlkgrevkdryaistlllkrv.dkeesrelthywy.kwleaevPaeeaaliamllevrs

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 43-282 5.5e-89 292.7 In-house 6-244 (250) alignment
Range on Protein: 43-282
Range on HMM: 6-244/250.0
HPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRkCDQYWPDRGTRN
.|.|| |||||.|.|.|.|||.| . .|  ||||||| ...||. . ||||.||||..|. ||||||.|. |. |||||.|.| ..  . ||||  ....
kpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaek

YGALRVTANETFHMSYYVLRTFLVSHMQEEEEpRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPP-TAGPMIVHCSAGVGRTGTFITLDSMLQRAA
|| ..|.  .. ... |. |.. .|. ....| |.|||.|...||| |||..    | ... | . ..   ..|.||.|||||||.|.||..|..|.|. 
yGdvtvsllskeefadytkrklklskakkade.rivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlk

QEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVIC
.| ..||| .....|..|  .|....||||.. .. .|. .
kekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 43-281 2.6e-42 139.9 In-house 38-278 (307) alignment
Range on Protein: 43-281
Range on HMM: 38-278/307.0
HPANKYKNRYANIVAYDHSRVLLTpLEGvLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDR-GTR
  ||  |||| .. . |..|.... ..| | |||| |||.    .   ||..|||| .|  .|| |. ..    ..|| .. | .. ||.||||   | .
fsantdknryqdvkcqdkgrivvk.fdg.lasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqk

-NYGALRVT----ANETFHMSYYVlRTFLV--SHMQEEEEPRQVRQYHYTSWPDHGVPAHPaplLSMVRTVSSANPpTAGPMIVHCSAGVGRTGTFITLD
  .|    |       . ...        |   ...  .. | .... .. |||.|||      |. .  ... .     |..|||||||||.|| ... 
lvfgeapntisvanlgakklapde.dlinvttlkvdwaqksrtiqhlqwenwpdrgvpqin...ltainlleavry.dtnpvvvhcsaGvGrsGtivais

SMLQRAAQ-EGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVI
 . ..  . .   |.  .|...|..|.  .||| ||...|  |.|  .
lvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfl

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 43-284 9.5e-37 121.5 In-house 32-275 (285) alignment
Range on Protein: 43-284
Range on HMM: 32-275/285.0
HPANKYKNRYANIVAYDHSRVLLTPlegvLESDYINANYID--GYNRSgAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGT
. ||   ||||.. . . .||.|       . ||| |...   | ..| ..|..|||||||. |||.|....  | ..||  | | |  ||  |.|..  
yeanpdlnryadvrcieetrvvlkn....hdrdyihaswmrmpgkdqs.tyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklg

--RNYGALRVTANETFH--MSYYVLRTFLVSHMQE-EEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPpTAGPMIVHCSAGVGRTGTFITLDS
   ..|   .|  |     ..  .| .. |   ..   ||  . . .   |||.  |    |.. . . |   ||    |. |||||||||| ||. .| 
evvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnp.kekpicvhcsagvgrtatfvgidy

MLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVIC-GV
   |  ..  |...  ||.||  |   ||.  |..|..  |.| .|  ||
atirimenpniemldivremramrfqavqshmqflflyvvlmeyfigegv

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 44-278 7.7e-76 249.8 In-house 26-266 (274) alignment
Range on Protein: 44-278
Range on HMM: 26-266/274.0
PANKYKNRYANIVAYDHSRVLLTPLEGVLE-SDYINANYIDGYNR-SGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTR
. ...|||| .|.  ..|||||.. ..  | |.||||||| ||.. | |..| |||||.| .|||||.... . .|||||.|.|. ..|| .|.||.   
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

----NYGALRVTANETFHMSYYVLRTFLVSHMQEeeePRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSAN---PPTAGPMIVHCSAGVGRTGTFITLD
    .|| . .. ... .   | .|.........   .|.|  | ||.|||| .| .. .||..|. |....      ..|..||||||.|||| ||. .
eiserygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiais

SMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVE
  ...  .|...||.. | ..| .|  ||||..|| .|| ||..
iavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 45-279 3.3e-75 247.3 In-house 6-239 (239) alignment
Range on Protein: 45-279
Range on HMM: 6-239/239.0
ANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRS-GAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRgTRNY
 || ||||||||.||||||.|  |     ||||||.|.  |. |  |.||.|| .  .  |||||.|..  ..||||| | |  ..|| |||||  | .|
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tsky

GALRVTANETFHMSYYVLRTFLVSHMQEEEEpRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQE
  ||||  .|  .. |..|||..|.. . || | | |||.| |||.||| . . .| . | ..  . | | | ..||||||||||.|. .|.||..| ..
cnlrvtlrktevfadyiirtfvmsqvgqtee.ryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

GTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEA
 |.|.| .|. .|. |  ||||  |||||| |..||
ktvdifnyvkairedrphmvqtseqyvfihlavlea

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 45-278 1.1e-74 245.6 In-house 7-239 (239) alignment
Range on Protein: 45-278
Range on HMM: 7-239/239.0
ANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRS-GAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRgTRNY
 || ||||||||.||||||.|  |     ||||||.|.  |. |  |.||.|| .  .  |||||.|..  ..||||| | |  ..|| |||||  | .|
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tsky

GALRVTANETFHMSYYVLRTFLVSHMQEEEEpRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQE
  ||||  .|  .. |..|||..|.. . || | | |||.| |||.||| . . .| . | ..  . | | | ..||||||||||.|. .|.||..| ..
cnlrvtlrktevfadyiirtfvmsqvgqtee.ryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

GTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVE
 |.|.| .|. .|. |  ||||  |||||| |..|
ktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 45-278 5.4e-69 227.0 In-house 2-237 (237) alignment
Range on Protein: 45-278
Range on HMM: 2-237/237.0
ANKYKNRYANIVAYDHSRVLLTPLEGVleSDYINANYIDGYNRS-GAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRG-TRN
 || ||||.||||||||||.|    .   ||||||.|..|.. .   .||.||||  . ||||.|||..  ..||||| | |. . || .|||.    . 
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGALRVTANETFHMSYYVLRTFLVSHMQEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANP--PTAGPMIVHCSAGVGRTGTFITLDSMLQRA
|| | |.     ..| | .|..|.|. .. .| | . ||..|||||.||| . | || . . .   .|  . .|| |.|||||||||| |. .|.||..|
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

AQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVE
 ..  .|.. .|  . . |  ..||. ||||||....|
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtile

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 45-295 1.8e-60 199.3 In-house 32-281 (283) alignment
Range on Protein: 45-295
Range on HMM: 32-281/283.0
ANKYKNRYANIVAYDHSRVLLTPLEGvlesDYINANYID---GYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTR
 || |||. .||..|  || | ..      ||||| .|     |...  .|..|.|| .|  |||.||...  . |||||.| |  | || |||| ||. 
enkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGse

NYGALRVTANETFHMSYYVLRTFLVSHMQEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAA
.|| . || .. .    .. . .|. .    ..   .  | .  | . |  |    |. . . .|  .    ||..||||.|.|||..||.. . .. | 
dyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdal

QEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANKLASR
 |  .|||  |. ||..|  .|||  || ..|.. .|  .|| |.. | .| | 
tesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdlqst

subfamily_ptpA1_pd Subfamily ptpA1 45-239 1.5e-44 147.4 In-house 46-255 (418) alignment
Range on Protein: 45-239
Range on HMM: 46-255/418.0
ANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNrSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTRNYG
 |  ||||.||.  .|.|| |  ..    |||||||||||      ||..|||||.|  ||||||||.   |||||..  |  | |||.|||..   .  
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqf

ALRVTANETFHMSYYVL--------RTFLVS--HMQEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSAN----P--PTAGPMIVHCSAGVGRTG
..    || |      |        |  .    ..  | | |.. ||.|  |||| .| |  |.  ......  .    |      |.||||||||||||
siygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtg

TFITLDSMLQR
|| |   |...
tfctavimmkk

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 45-281 9.5e-20 65.4 In-house 46-280 (303) alignment
Range on Protein: 45-281
Range on HMM: 46-280/303.0
ANKYKNRYANIVAYDHSRVLLTplegvlESDYINANYIDgYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRG-TRNY
 |  |||.....  |||.| |.      .| || |.|..  . |   | .| ||. |  |||.|. ||    ...|    |  .   |  .|      ..
knmdknrfvdvicldhskvkls......dssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

G--ALRVTANETFH-MSYYVLRTFLVSHMQeeeEPRQVRQYHYTSWPDHGVPAHPAPL-LSMVRTVSSA-NP-PTAGPMIVHCSAGVGRTGTFITLDS-M
   ..||        .  .||.   ||  .       .  .|| .||   .|.. .|  .  .  . |       . | .    .|.||.|||  ...  
eersirvgefkrvelgdgwvlkvlsvsngd...yksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetah

LQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVI
|   ... ..|.   . ..|| |   ||  ||. ...  | | |.
lslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 45-277 2.7e-16 53.9 In-house 50-282 (302) alignment
Range on Protein: 45-277
Range on HMM: 50-282/302.0
ANKYKNRYANIVAYDHSRVLLTplegVLESDYINANYIDGYNRSGAFIASQGPLPETF---DDFWRMVWEQGSAIIVMLTQLEERGRrKCDQYWP-DRGT
.|  ||.  .. ..|. .| |.      . .|.||  ..  . .   | .| |  ..    ..|||||...  . .|.| . ||  .   ....|   |.
knlkknqsedvpildsnlvkle....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgd

-RNYGALRVTANETFHMSYYVlRTFLVSHMQEE-EEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQ
  .||...|      ...  .   . .  . |.  .   .  |. | |... || . | |   .  |   . ..  ....    |.|| |.|.||   ..
ykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavave

RAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALV
.  ..    .   |...|..|  .|.. .|||... ||.
klqkgkepnikeivksiRsqRpravdslkQyvslyiall

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 45-196 5e-10 32.6 In-house 26-159 (169) alignment
Range on Protein: 45-196
Range on HMM: 26-159/169.0
ANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINAnyidgynrsgafiasqgplpetfddfwRMVWEQGSAIIVMLTQLEERgrrkcDQYWPDRGTRN--
.|. ||| |  .|  | || |  .   | ||||||                           ||.||  ...||.| . ...     ...||..   .  
cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddk.....nnfwpekedyqlh

---------YGALRVTANETFHMSYY---VLRTFLVSHMQEEEEPRQVRQYHYTSWPDHGVPAHPA
           .| | ..     .     ..   .| |  ...   ... .||..||. |||  | 
pavilgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqspv

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 45-196 5.8e-10 32.3 In-house 25-158 (169) alignment
Range on Protein: 45-196
Range on HMM: 25-158/169.0
ANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINAnyidgynrsgafiasqgplpetfddfwRMVWEQGSAIIVMLTQLEERgrrkcDQYWPDRGTRNYG
.|. ||| |  .|  | || |  .   | ||||||                           ||.||  ...||.| . ...     ...||..   .  
cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddk.....nnfwpekedyqlh

AlRVTANETFHMSYYV---------------LRTFLVSHMQEEEEPRQVRQYHYTSWPDHGVPAHPA
   |   | .  | ||               .   || |  ...  .|.. .||..||. |||  | 
p.avilGewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspv

Y_phosphatase Protein-tyrosine phosphatase 46-278 9.4e-90 295.5 Pfam-A 1-235 (235) alignment
Range on Protein: 46-278
Range on HMM: 1-235/235.0
NKYKNRYANIVAYDHSRVLLtplEGVLE-SDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWP--DRGTRN
|| |||| .|..||..|| |   .|  . ||||||||..||... .|||.||||..|..|||||||.. . .|||||.|||.||.||.||||  .... .
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGALRVTAN-ETF-HMSYYVLRTFLVSHMQEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRA
|| ..|.   ..  ... |.||.. ... .||.|.|.|.|.|||.|||||||..| .||...| | . . .. ||..|||||||||||||..|| .|...
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

AQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVE
 .|...||. .|...|..|. |||...||.|...|..|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 46-278 9.4e-90 295.5 In-house 1-235 (235) alignment
Range on Protein: 46-278
Range on HMM: 1-235/235.0
NKYKNRYANIVAYDHSRVLLtplEGVLE-SDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWP--DRGTRN
|| |||| .|..||..|| |   .|  . ||||||||..||... .|||.||||..|..|||||||.. . .|||||.|||.||.||.||||  .... .
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGALRVTAN-ETF-HMSYYVLRTFLVSHMQEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRA
|| ..|.   ..  ... |.||.. ... .||.|.|.|.|.|||.|||||||..| .||...| | . . .. ||..|||||||||||||..|| .|...
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

AQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVE
 .|...||. .|...|..|. |||...||.|...|..|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 46-278 1.6e-64 212.5 In-house 20-262 (270) alignment
Range on Protein: 46-278
Range on HMM: 20-262/270.0
NKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYN-RSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGT----
.|  ||||.|.   ..|| | .||   .. ||||||. |.. .. ..||..|||| |  .||||.||. .  |||.|.|||.||.||..||| .      
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

RNYGALRVTANETFHMSYYVLRTFLVShmqEEEEPRQVRQYHYTSWPDHGVPAHPA------PLLSMVRTV--SSANPPTAGPMIVHCSAGVGRTGTFIT
 ..| ..|.| .. ... |.|.   .    |. | |..  ..|..||||||| ..        ||.|.|.|  |. .   |.|..||||||||||||.|.
ledgkikvlalseekeegyiltrlrle...ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlia

LDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVE
|| ...   ... .||   ....|..|  .||.  || |.. |.||
lDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve

0041856 (Phosphotyrosine protein) phosphatases II 46-286 1.8e-55 182.6 In-house 1-177 (182) alignment
Range on Protein: 46-286
Range on HMM: 1-177/182.0
NKYKNRYANIVAYDHSRvlltplegvlESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTqleergrrkCDQYWPdrgtrnyga
|. |||| .|. |||||           .||||||...|. ..  ||| ||||..|. ||.||..|.|  .||.||         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

lrvtanetfhmsyyvlrtflvshmqeEEEPRQVRQYHYTSWPDHGVPAhPAPLLSMVRTVSSanppTAGPMIVHCSAGVGRTGTFITLDSMLQRaaqegT
                          |...|.. ||.|..|||||||  .  ||.....| .      || .||||||||||||.. .. |...      
..........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....g

IDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTE
....  |...|..|. ||.|..||.|...|| | . ...|.
vsleeavklvrsrRpgmvitpnqyfflqlallellllkktr

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 46-280 2.1e-37 123.4 In-house 55-289 (305) alignment
Range on Protein: 46-280
Range on HMM: 55-289/305.0
NKYKNRYANIVAYDHSRVLLTPLEgvlESDYINANYIDGY-NRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDR-GT---
.. ||||... . |.| |.|        |||| |||.         ||..|||| .| |.|| || ..    |||| .  | |. || ||||   |    
aitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

RNYGALRVTANETFHM--SYYVLRTFLVSHMqEEEEPRQVRQYHYTSWPDHGVPahPAPLLSMvrTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQ
 . | .      .  |     .  | |   .   ..   ||. ..| ||| |||  |. | |.   . ||   .  |..||||||.||||| .... .|.
lksgivvenvsgskpmerdaeiqitllnlty.sgdqkmsvrhlqwtewpdrgvp..pckltsl..ellsairgskvpivvhcsagigrtgtivaieyile

RAAQEGTI-DVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAV
. |..     .  .|. .|..|   .|.. ||.|||  ... .
kiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 46-139 1.5e-14 48.2 In-house 34-126 (332) alignment
Range on Protein: 46-139
Range on HMM: 34-126/332.0
NKYKNRYANIVAYDHSRVLLTPLEGvlESDYINANYIDGYNRSGAFIASQGPLPETF-DDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRG
|   ||   . ..||||| |.| .|  . |. ||...|||..  |.| .| |. .     ||||| |.  ..|... ...|. .||.     |||
nmdmnriphlycfdhsrvelapqdg..kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapydisdrg

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 46-114 1.2e-09 32.2 In-house 37-110 (347) alignment
Range on Protein: 46-114
Range on HMM: 37-110/347.0
NKYKNRYANIVAYDHSRVLLTPLEGVLE-----SDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGS
.  |||  .    | .||.|.| .           |||| .|   | |  .| .| |||.|  |||.||     
slsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkv

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 47-280 5e-28 92.7 In-house 44-276 (312) alignment
Range on Protein: 47-280
Range on HMM: 44-276/312.0
KYKNRYANIVAYDHSRVLLTPLegvlESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDR-GTRNYGA
|  ||| ||  .|  |  |.      |  || ||..    .   |...|||| .|   ||...   ||. |..|. . | |  || .|  |  |  .   
kdlnrypniqcwdrgrftlagd....enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdled

LRVTANE----------TFHMSYYVLRTFLVSHMQEeeepRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSanppTAGPMIVHCSAGVGRTGTFITLDS
 || ..             .... ||.  . .  ||     .. .| ..||||||.|      | .. .|         |.| |||||||||||.. ..|
hrvyteycteieiggkskdkithrvlkvvvkatgqe....sklnhyqwaswpdhgmpdscdtalrllsavkk....dkkpviahcsagvgrtgtlalies

MLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAV
|.    .    .|      .|. |   |..  |||.   ...| .
miaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefl

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 48-277 6.8e-21 69.7 In-house 21-256 (290) alignment
Range on Protein: 48-277
Range on HMM: 21-256/290.0
YKNRYANIVAyDHSRVLLTPLEGVLESDYINANYIDgYNRSGAFIASQGPLPET-------FDDFWRMVWEQGSAIIVMLTQLEERGRR----KCDQYWP
 ..|... ..  ..|| |      . .||| ||..  .    ..|..| |. ..         .|| |. .  .  .||| . ||. .      | .| |
mdqRlevpLv.eatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvp

DRGT--RNYGALRVTANETFHMSYYVLRTFLVSHmqEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSAnpptAGPMIVHCSAGVGRTGTFITLD
..     ... | |   .  .      |. .| .  ..||. .|  . . .| .  |. ..  |||....|         |.||||  |. |  .. ...
esvgeelkfkgltvkCkskekeddvetRelvvkf..ddeeeftvtHsllkgWnklnvqedtktllsliqkvkas....ktpvivHcvdGiSrsAalaaii

SMLQRAA-QEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALV
   |  | ..| . .   . ..|..|.|..... .. |.  ..|
lgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 48-147 2.2e-17 57.4 In-house 50-162 (349) alignment
Range on Protein: 48-147
Range on HMM: 50-162/349.0
YKNRYANIVAYDHSRVLLT--------------PLEGVLESDYINANYID--GYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKC
 |||| .|. |.|||| |                 ..    |||||||.    ..    .|| | ||| | |||....  .|  ... |.. .| . .||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

DQYWPDRgtrNYGALR
|.|| .    .|   .
diywqel...sysnit

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 49-143 4.5e-26 86.4 In-house 50-158 (350) alignment
Range on Protein: 49-143
Range on HMM: 50-158/350.0
KNRYANIVAYDHSRVLLT----PLE----GVLESDYINANYIDGY----NRSGA--FIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQY
|||| ||. |.|||| |     . .     .  .|||||||.       .      .|| |.|||.|.|||.... . .  .|..||.. | ...||..|
knrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrY

WPDRGTRNY
|.. .  ..
Wqegsyddi

subfamily_eak_pd Subfamily eak 49-280 1.5e-18 61.3 In-house 55-305 (332) alignment
Range on Protein: 49-280
Range on HMM: 55-305/332.0
KNrYANIVAYDHSRVLLTPLEgVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRG--TRNYGAL
.|   .|| ||.  | ||.     .  ||||  ..  .    .| .  .  .    ||.|| || |  ||.| .  | .  | |.|.||..    ..| |
rn.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGil

RVTANETFHMSYYVLRTFLVSHMqeeEEPRQVRQYHYTSWPDHGVPAHP-------------APLLSMVR-T-VS------SANPPTAGPmIVHCSAGVG
 |.  |  . . .  | . .|     .|  .|  |..  | .  .|                ..||  .. . .|         ||.  | |. .. |  
dverkefvkrniletrllelskG...nethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfap.iiqsarGsa

RTGTFITLDSMLQRA--AQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAV
|.|.|. .| ...     .. .  |  .. ....||.  | .. |. ||...... .
raGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyl

0044763 (Phosphotyrosine protein) phosphatases II 58-275 5.5e-42 138.7 In-house 2-166 (178) alignment
Range on Protein: 58-275
Range on HMM: 2-166/178.0
YDHSRVLLTPLEGVLESDYINANYIDGYnrsgAFIASQGPlpetfDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTrnygalrvtanetfhms
.|..||||..|||.. ||||||..|...     ...|..|      |......|.|   ||.||.  |.|. |||.|||..                   
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

yyvlrtflvshmqeeeeprqvRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRaaqegTIDVFGFVRQMRN
                      ||... .||||||  .. .| .|. . .| ..  || .|||||||||.||.. .. |...      ....  ....|.
.....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvre

KRNlMVQTESQYVFIHDA
.|. .|....|. .... 
rRp.ivpnpgqlrqLyef

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 58-190 1.3e-09 32.5 In-house 5-125 (130) alignment
Range on Protein: 58-190
Range on HMM: 5-125/130.0
YDHSRVLltplegvlESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERgrrkcDQYWPDRGTRNYGALRVTANETFHMS
.. ||.         . .||||...   .|.  .. .| || .|  |||.|. |.   ..|.|  .||      |.||||    ..   ...   | .  
fevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdrde

YYVLRTFLVSHMQEEEE-PRQVRQYHYTSWPDHG
.  ...  .   ..  |  . .  .. . ||  |
fknikasnleiesdlneshqaltmfqisnwpsdg

0046846 (Phosphotyrosine protein) phosphatases II 67-276 4.8e-46 152.0 In-house 5-169 (176) alignment
Range on Protein: 67-276
Range on HMM: 5-169/176.0
PLEGVLESDYINANYIDGYnrsgAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTRNYgalrvtanetfhmsyyvlrtflv
.|   | .||||||.|.|.    ..|| |||||.|. ||..|..|.|  ..|.||.. | || ||..|||.  . ..                       
llgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

shmqeeeeprqvrQYHYTSWPDHGVPAHpAPLLSMVRTVSSANPPTaGPMIVHCSAGVGRTGTFITLDSMLQraaqEGTIDVFGFVRQMRNKRN-LMVQT
             ||... ||||||| . . ||.... . .|     || .||||||.|||||.. .. .      |  ..|.  ....|..|   .|||
.............qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqt

ESQYVFIHDAL
..|| |.....
peQyrflyefe

0051429 (Phosphotyrosine protein) phosphatases II 74-301 1.7e-63 210.1 In-house 4-245 (272) alignment
Range on Protein: 74-301
Range on HMM: 4-245/272.0
SDYINANYIDGYNR---SGAFIASQGPLPETFDDFWRMvWEQGSAIIVMLTQLEERGRRKCDQYWP------------DRGTRNYGALRVTANETFHMSY
|.||||....||.|    |....|.|||| | .||||. .|.|   ||.|...||||| |||.|||            .  | .|||||||  .......
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

YVLRTFLVSHMQEEEEPRQVRQYHYTSWPDHGVPAHPapLLSMVRTVSSanpptAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTID--------VFG
|.||..|....   .|.|.|...|||.||||||| ..  ||.... . .      ||..||||||..||||.. |. .|..   |  .|        ...
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlylee

FVRQMRNKRNLMVQTESQYVFIHDALVEAvICGVTEVDANKLASRIRELRE
.|...| .|  .|||| ||.|...||.|. ......|.|. |.. .....|
aveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaaldaide

0036282 (Phosphotyrosine protein) phosphatases II 74-274 4e-53 175.0 In-house 2-164 (174) alignment
Range on Protein: 74-274
Range on HMM: 2-164/174.0
SDYINANYIDGYNRSGAFIASQGPLPetfddFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDrgtrnygalrvtanetfhmsyyvlrtflvshmQEEE
||||||...|.. ... .||.||||.     ||.|..|.|. ..|||....|.|. || .|||.                                  | 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lred

EPRQVRQYHYTSWPDHGVPAHPApLLSMVRTVSSANPP-TAGPMIVHCSAGVGRTGTFITLDSMLQRAAqEGTIDVFGFVRQMRNKRNLMVQTESQYVFI
. | . ||.|. |||||||  .  ||..|. | .|      ||..||||||||||||.. .. ||..   |...|.. .||..|..|  ||||.||| |.
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

HD
..
yy

0043147 (Phosphotyrosine protein) phosphatases II 74-273 8.7e-48 157.6 In-house 5-154 (172) alignment
Range on Protein: 74-273
Range on HMM: 5-154/172.0
SDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLeergrrkcdqywpdrgtrnygalrvtanetfhmsyyvlrtflvsHMQEEE
||||||.|.|.|     ||| ||||..|..|||||..|.|  .||.||.|                                                | 
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lydpel

EPRQVRQYHYTSWPDHGVPaHPAPLLSMVRTVSS-ANPPTAGPMIVHCSAGVGRTGTFITLDSMLqraaqeGTIDVFGFVRQMRNKRNLMVQTESQYVFI
. |.. ||.|..||||||| ... ||.... . . ..    ||..||||||||||||.. .. ||        ....  |...|.||. .||..||| |.
lerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrfl

H
.
y

0051082 (Phosphotyrosine protein) phosphatases II 74-276 6.7e-40 131.4 In-house 3-149 (151) alignment
Range on Protein: 74-276
Range on HMM: 3-149/151.0
SDYINANYIDGYnrsgaFIASQGPLPetfdDFWRMVWEQGSAIIVMLTQLEERGrrKCDQYWPDRGtrnygalrvtanetfhmsyyvlrtflvshmqeee
|||||..|..|.     ...|.|||.    ||.....|.|   ||.|...||||  .| .|.|. |                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

epRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSanpPTAGPMIVHCSAGVGRTGTFITLDSMLQRaaqegtIDVFGFVRQMRNKRNLMVQTESQYVFIH
  ..|.......|||.|.| ... .|.... . .   .  ||..||||||.|||||.. |. ||..      ....  ....| ||  .||.. |..|..
..ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

DAL
 ||
fal

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 77-272 2.3e-32 106.9 In-house 78-273 (301) alignment
Range on Protein: 77-272
Range on HMM: 78-273/301.0
INANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTRNYG----ALRVTANETFHMSYYVLRTFLVSHMQEE
| ||.|.   ..  |||.||||..| .||| |.       ||||.|  |.  .||..| | . ...       .... .|.      . ||. |    ..
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

EEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANpptaGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFI
 ..| |  | |..|.|.|||   | |  ..  |  ..     |..||||||.||. .||. . . ..   . ||..   ....|..|   |||.||  ..
fatrtvthyqysewtdrgvPkshaelfdlmelvkkse....kPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywm





0049260 (Phosphotyrosine protein) phosphatases II 81-274 1.1e-45 150.3 In-house 1-144 (152) alignment
Range on Protein: 81-274
Range on HMM: 1-144/152.0
YIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWpdrgtrnygalrvtanetfhmsyyvlrtflvshmqeeeeprqvrQ
.||||... .||| |||.|.|..|||||..|.|  .|||||.|.|.|. ||.||.                                            |
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................q

YHYTSWPDHGVPAHPAPLLSMVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLqraaqeGTIDVFGFVRQMRNKRNLMVQTESQYVFIHD
|... ||||||| ..  || ... .  ..    || .||||||||||||.. .. ||        .... .|...|.||. .|....|. |...
ylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 83-177 2.6e-11 37.5 In-house 230-322 (440) alignment
Range on Protein: 83-177
Range on HMM: 230-322/440.0
DGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERgrrKCDQYWPDRG-TRNYGALRVTANETFHMSYYVLRTFLVSHMQEEEEPRQ
.|| .  ||||.| ||  |  ||||.| .   . |.|| ||...    |  |||    .  .| . |  . .  |    .||. . . .|  | ||
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevheirq

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 90-273 1.7e-24 81.1 In-house 6-197 (199) alignment
Range on Protein: 90-273
Range on HMM: 6-197/199.0
AFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWP--DRGTRNYGALRVTANETFHMSYYVLR-TFLVSHMQEEEEPRQVRQYHYTSW
 .||.| || ||. |||.|||| ||  |||. . .         |||  . || .||.| ||..     . |..    |..        |.. .| .|||
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PDHGVPAHP--APLLSMVRTVSSA-NPPTAGPMIVHCSAGVGRTGTFITLDSMLQRA--AQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIH
 ..  |       ..   | ||   .     |.||||| | | || |..||  ..    ..   .|.|   ...|. |  .. .  .| ||.
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 90-273 1.8e-24 81.0 In-house 5-196 (198) alignment
Range on Protein: 90-273
Range on HMM: 5-196/198.0
AFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWP--DRGTRNYGALRVTANETFHMSYYVLR-TFLVSHMQEEEEPRQVRQYHYTSW
 .||.| || ||. |||.|||| ||  |||. . .         |||  . || .||.| ||..     . |..    |..        |.. .| .|||
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PDHGVPAHP--APLLSMVRTVSSA-NPPTAGPMIVHCSAGVGRTGTFITLDSMLQRA--AQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIH
 ..  |       ..   | ||   .     |.||||| | | || |..||  ..    ..   .|.|   ...|. |  .. .  .| ||.
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 97-276 8.8e-23 75.2 In-house 99-284 (302) alignment
Range on Protein: 97-276
Range on HMM: 99-284/302.0
PLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDR--GTRNYGALRVT---ANETFH----MSYYVLRTF-LVSHMQEEEEPRQVRQYHYTSW
|  .| . .| .. .   ||.| |... | . .|| .|. |.  |. ..|   |.    .. ..       ..| |  .  . .... .. |   ....|
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDHGVPAHPAPLLSMVRTVSSANpptaGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDAL
|||| |... . | ...   |        ..||||||||||||....   .|  ... . |.   |  .|. |   ||.|.| ...   .
pdhGapkeaytaldilkfcesyk....knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcv

subfamily_hpo-7_pd Subfamily hpo-7 100-281 1.3e-20 68.5 In-house 45-228 (263) alignment
Range on Protein: 100-281
Range on HMM: 45-228/263.0
ETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDR--GTRNYGALRVTANETFHmsYYVLRTF-LVSHMQEEEEPRQVRQYHYTSWPDHGVPAHPA
.| | |....  ...  .|||.  .| |. ||..|.|    . . .  . |.. .. .    .|.|  |.| ..|  . ..|..| |. |...  |  . 
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelar

PLLSMVRTVSSANpptagPMIVHCSAGVGRTGTFITLDSMLQ------RAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVI
  | ... .         ...||||.|.||.  |   ... |      . .. . .|   .....|..|.  ..|  |  |    ... |.
eilnilkvarnsk.....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvl

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 101-280 2.4e-24 80.8 In-house 40-221 (255) alignment
Range on Protein: 101-280
Range on HMM: 40-221/255.0
TFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGT--RNYGALRVTANEtfHMSYYVLRTF-LVSHMQEEEEPRQVRQYHYTSWPDHGVPAHPAP
| | |....  ...  .|||. ..| |. ||..|.|      . .  . ||. .   ..  ||||  ..|.. |  . ..|. |.|. |...  |  .  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

LLSMVRTVSSANpptagPMIVHCSAGVGRTGTFITLDSMLQ------RAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAV
.| ... |  .      ...||||.|.||. .|.  ... |      . .. . .|   .....|.||.  ..|  |  |    ... |
ilnilkvvrdsk.....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv

0048076 (Phosphotyrosine protein) phosphatases II 134-276 2.9e-28 93.7 In-house 2-139 (145) alignment
Range on Protein: 134-276
Range on HMM: 2-139/145.0
YWPDRGTRN--YGALRVTANETFHMSYYVLRTFLVSHMQEEEEpRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPPTaGPMIVHCSAGVGRTGTFI
|||.. . .  .| | .. .  .  .. . . . .....| .| |.. ||.|..|||||||  .. ||.... . .| .   ||..||||||||||||..
ywpseilpglylgslptaldlellkdlgittvlnltselelle.rlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlv

TLDSMLQraaqEGtIDVFGFVRQMRNKRNLMVQTESQYVFIHDAL
 .. ||.    .| ....  ....|..|  .|....|. |.....
aaylmll....lg.vsleealelvrsqrpgavpnpgqlrflyefe

0048179 (Phosphotyrosine protein) phosphatases II 170-274 2.6e-26 87.5 In-house 41-139 (144) alignment
Range on Protein: 170-274
Range on HMM: 41-139/144.0
QEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPPTaGPMIVHCSAGVGRTGTFITLDSMLqraaQEGtIDVFGFVRQMRNKRNLMVQTESQY
  |.. |.. ||....||||||| ... ||.... . .| ..  ||..||||||||||||..... |.     .| ....  ....|..|  .|....|.
epefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgql

VFIHD
 |...
rfLle

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 171-277 1.6e-10 34.9 In-house 213-341 (349) alignment
Range on Protein: 171-277
Range on HMM: 213-341/349.0
EEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVR-------TVSSA---NPPTAGPMIVHCSAGVGRTGTFITLDSMLQ--RAAQ---------EGTID-V
..|.| .. |  .  |.| ..   |  .|  .        .  .    .     ...|||||| ||||...|||..|.     |           . | .
avekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDli

FGFVRQMRNKRNLMVQTESQYVFIHDALV
.  | ..| .|  |||  .|...|..||.
siivnelrkqrismvqnlaqfiaiyealL

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 173-319 3.1e-35 116.3 In-house 86-233 (440) alignment
Range on Protein: 173-319
Range on HMM: 86-233/440.0
EEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSS-ANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVF
 | | ..|||| .|||.|||   .|.| |.. |.   .    ||..||||||.||||  |..||.|. | .   ||.| |.  |||.|  ||||  ||.|
iesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

IHDALVEAVICGVTEVDANKLASRIRELREVDPNIGTTYMDLEFERLT
.|.|..|...|| | .  . .. |. ...  .|.   . .. |||  .
vheavlegllcgdtliledditerveqiqwpnphtdksplqqefegys

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 174-277 5.5e-16 53.2 In-house 213-341 (350) alignment
Range on Protein: 174-277
Range on HMM: 213-341/350.0
EPRQVRQYHYTSWPDHGVPAHPAPLLSMVR-------TVS---SANPPTAGPMIVHCSAGVGRTGTFITLDSMLQ-----RAAQ---------EGTID-V
.|  | | ..  |.| ..  .|  .|...        .       .   . |..||||||||||||..||||.|.     .  .           | | .
dPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDli

FGFVRQMRNKRNLMVQTESQYVFIHDALV
.  | ..|..|  |||.  |..||..|| 
siivnelrkqrismvqnldqfifiYeall

PTEN_1 175-262 2.6e-06 22.4 In-house 91-177 (196) alignment
Range on Protein: 175-262
Range on HMM: 91-177/196.0
PRQVRQYHYTSWPDHGVPAhPAPLLSMVRTVSSANP--PTAGPMIVHCSAGVGRTGTFITldSMLQRAAQEGTIDVFGFVRQMRNKRNLM
 ..  .|.  ...|||.|   . |. ... . ..    |  .  .||| ||.||.|| .   . | .. .    . . .||..| .... 
fksgveylhfpieDhgaps.lselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva..ayLmykgkltadeAlelvrekRppgapn

subfamily_PTPDC1_pd Subfamily PTPDC1 176-274 2.3e-09 31.9 In-house 81-170 (182) alignment
Range on Protein: 176-274
Range on HMM: 81-170/182.0
RQVRqYHYTSWPDHGVPAhPAPLLSMVRTVSSANppTAGPMIVHCSAGVGRTGTFITLDSMLQRAaqegtIDVFGFVRQMRNKRNLMVQTESQYVFIHD
...  ..  .|.|.||..    .| .|. |..|   . | . ||| || ||||  |.   . ..      ..    .. .|.||   .|| .|  ....
qgiy.vynfgwkDygvas.leriLdivkvvafal..qegkvavhChaGlGrtGvliacylvyakr.....ltaekaiklvrskrpksiqtreqvelvke

0038934 (Phosphotyrosine protein) phosphatases II 176-233 8.5e-08 27.6 In-house 77-135 (194) alignment
Range on Protein: 176-233
Range on HMM: 77-135/194.0
RQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANP-PTAGPMIVHCSAGVGRTGTFITL
.   .|.   .||.|..   . ||. .. |   .   . |   ||| ||.|||||..  
kagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa

PTPc_DSPc_SM00012 177-277 9.9e-38 123.9 In-house 1-104 (105) alignment
Range on Protein: 177-277
Range on HMM: 1-104/105.0
QVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPPTA--GPMIVHCSAGVGRTGTFITLDSMLQRAAQE-GTIDVFGFVRQMRNKRNLMVQTESQYVFIH
.|..||||.||||||| .. ..|...| | . .   .  .|..|||||||||||||..|| .||.  .| ...|.| .|...|..|. ||||| ||.|..
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

DALV
.|| 
rall

subfamily_CDC14_pd Subfamily CDC14 200-257 8.5e-06 19.8 In-house 250-305 (328) alignment
Range on Protein: 200-257
Range on HMM: 250-305/328.0
SMVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQraAQEGTIDVFGFVRQMRN
..|.   ..   . | ..||| ||.|||||.|.   | .   .  . .. ...| .| 
aivkkfleiaekaeGaiavhCkaGLGrtGtLiacylmkh..yrftaaeaiawlricrP

subfamily_CG42327_pd Subfamily CG42327 212-276 6.7e-14 46.3 In-house 246-311 (319) alignment
Range on Protein: 212-276
Range on HMM: 246-311/319.0
TAGPMIVHCSAGVGRTGTFITLDSMLQRAAQE-GTIDVFGFVRQMRNKRNLMVQTESQYVFIHDAL
  ||..|||| ||||||. |. |  ...  .   ..|.   | ..|. |   |.|  || ||.  |
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 216-282 2.7e-21 69.7 In-house 1-67 (69) alignment
Range on Protein: 216-282
Range on HMM: 1-67/69.0
MIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVIC
|.||||.| |||||||..   . |   |  .|.|  |. ||  | .||  | .|.|||||||||.  
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealkl

subfamily_PTEN_pd Subfamily PTEN 216-272 6e-06 21.4 In-house 117-172 (184) alignment
Range on Protein: 216-272
Range on HMM: 117-172/184.0
MIVHCSAGVGRTGTFITLDsMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFI
..||| || ||||. |.   .|..   | . ..  .  ..| | .  |.  ||  ..
vvvHCkaGkGRtGvlivay.llkslllekaeealelfaeaRtknkkgvtiPsqrRYv

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 217-282 6.2e-20 65.3 In-house 1-66 (69) alignment
Range on Protein: 217-282
Range on HMM: 1-66/69.0
IVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVIC
.||||.| |||||||..   . |   |  .|.|  |. ||  | .||  | .|.|||||||||.  
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealkl

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 283-577 2.8e-102 337.0 In-house 1-297 (298) alignment
Range on Protein: 283-577
Range on HMM: 1-297/298.0
GVTEVDANKLASRIRELREVDPNIGTTYMDLEFERLTRDER--HPTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKA
| ||..|..|   ...| .|... . | ..|||.||.. .   . .. . |  . |  |||||.|.... .|| |.   ..  ||||||||... .. .|
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

YIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSDGSRLYDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGL
.||||||...|.||||||..|.....|||||  || .|.|.|.|||..|.. |..| |.| .. ...|.. |.. .....|...| |||.. | ||| | 
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgv

PESGVGLIDLIGQVEKWQQQSGNTCITVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLESFDLYA
||    ..||. .|...|||.||. ..|.|| ||||.| |.|.. ..||||.|  .||||.|. || .||..|||..|| |.|. ..|.|.||. ..
penatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei

subfamily_PTPN6_pd Subfamily PTPN6 285-572 9.9e-82 269.3 In-house 2-299 (306) alignment
Range on Protein: 285-572
Range on HMM: 2-299/306.0
TEVDANKLASRIRELREVDPNIGTTYMDLEFERLTR-DERHPTQFKSAMLSCNAAKNRYANILPYERTRVALHmRPGEVGSDYINASFIDGNH--RLKAY
|.. |... .|..||.. . ... . .  |||.| . ....  . | .    |. |||| ||||.. ||| |. .|. .|||||||..|...     |.|
tsllakeieqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksy

IATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSDGS-RLYDKILVELTEELTYSDYVLRQFSLTH-TEEKSSRIVRQFQCTDWPDSG
||||  .. | .|||||.|...| ||||.|.| | || || ||||.  . . | || |. ..| . .||.||..|... ...|..| |.|.. ..||| |
iatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhg

LPESGVGLIDLIGQVEKWQQQSG---NTCITVHCSGGVGRTGVFCAVSILIERVKAEGL---IDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLES
 |..   ..|.. .|.. |...    .  | |||| |.|||| |  . ||.. .. .||   ||. ..|. .| ||  .|||..|| | |..|..|.|.
vpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet

0051299 (Phosphotyrosine protein) phosphatases II 286-570 9.6e-100 329.0 In-house 4-286 (288) alignment
Range on Protein: 286-570
Range on HMM: 4-286/288.0
EVDANKLASRIRELRevdpNIGTTYMDLEFERLTRDERHpTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQ
|.....|......|.      |.|..  |||.|..   .  ....|.| .|  |||| .||||...|| |.. .|. ||||||||.||| .. ...||||
eisveellklvlkll....angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatq

APVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSDGSRLYDKILVELTEELTYSDYVLRQFSLTHT----EEKSSRIVRQFQCTDWPDSGLP
.| | |.||||||.|||.. ||||||...| |. ||..|||..||  |..| |.|..| ...||..|.. .|..     .. ||.|..|..|.||| | |
gPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvp

ESGVGLIDLIGQVEKWQQqSGNTCITVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
.|   |.|.. .| |... ||. .. |||| ||||||.|.|. .|.|....|| .||...|..|| ||| |||| .||.|.| .. |||
dspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 298-579 2.5e-76 251.4 In-house 9-287 (287) alignment
Range on Protein: 298-579
Range on HMM: 9-287/287.0
ELREVDPNIGTTYMDLEFERLTRDERHPTQFKSAMLSCNAAKNRYANILPYERTRVALHmrpgEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWR
|. . ... | .     |  | . .... .   .. | |  |||...||...  || |.    .   |||||.|||| .  ||.|....|. .|  .||.
efvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWk

MLWEQESAVIVMLTREEEAGKLKCHRYWPSDGSRLYDKILVELTEELTYSDYVLRQFSLTHTE-EKSSRIVRQFQCTDWPDSG-LPESGVgLIDLIGQVE
......  .||||..|.|  . .|..|||.. | .. .  .||..| ....|. |.. ..... ... . |.|.| |.|.. | ..|     . .| .  
liddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqt.illvieemy

KWQQQSGNTCITVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLESFDLYANF
| |...||| | |||| .|||...|||. . |...| || ||||| ... | |.| .||| .||.| .  ..|||.||..|..|
ktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf

0050432 (Phosphotyrosine protein) phosphatases II 299-577 4.1e-100 330.3 In-house 32-306 (308) alignment
Range on Protein: 299-577
Range on HMM: 32-306/308.0
LREVDPNIGTTYMDLEFERLTRDERhPTQFKSAMLSCNAAKNRYANILPYERTRVALhmrpgEVGSDYINASFIDGN--HRLKAYIATQAPVPRTFEDFW
|. ... ....... |||.|..    . ....|.| .|  |||| .||||...|| |     . ||||||||..||   .. ...||||.| | |.||||
lkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFw

RMLWEQESAVIVMLTREEEAGKLKCHRYWPSD---GSRLYDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQ
||.|||.. ||||||...| |. ||..|||..   ||. |.|. |.|..| ...||..|.. ||..... ||.|..|..|.||| | |.|   |.|.. .
rmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflel

VEKWQqqsGNTCITVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLESFDLYA
|.|..   ..  | |||| ||||||.|.|. .|.|....|| .|||..|..|| ||| ||||..||.|.| ...|||...  ..
vrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltkl

0039614 (Phosphotyrosine protein) phosphatases II 301-571 2.1e-93 308.3 In-house 24-290 (297) alignment
Range on Protein: 301-571
Range on HMM: 24-290/297.0
EVDPNIGTTYMDLEFERLTRDERhPtqFKSAMLSCNAAKNRYANILPYERTRVALHMRPGE-VGSDYINASFIDGNHR-LKAYIATQAPVPRTFEDFWRM
 ...  ..|...||||.| .    .  .. |.| .|  |||| .||||...|| |.. .|   .|||||||..|| ..  ...||||.| | |.||||||
llekansktllllefeellslkp.d..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrm

LWEQESAVIVMLTREEEAGKlKCHRYWPSDGSrLYDKILVELTEELTYSDYVLRQFSLTHteEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQ
.||| . ||||||...| |. ||..|||..|.  |... |.|... ....|..|....|.  .. ||.|..||.|.||| | |.|   |.... .|....
vweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvreal

QQS-GNTCITVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLE
... ..... ||||.||||||.|.|  ...|... || .||...|..|| ||| .||| .||.|.|  ..|.| 
aelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk

0047943 (Phosphotyrosine protein) phosphatases II 302-570 2.1e-94 311.3 In-house 5-272 (273) alignment
Range on Protein: 302-570
Range on HMM: 5-272/273.0
VDPNIGTTYMDLEFERLtRDERHPTQFKSAMLSCNAAKNRYANILPYERTRVALhmrpGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWE
...  |.|.. .|||.| ..  ..  .. |.| .|  |||| .||||...|| |    |. ||||||||..|| .. ...||||.| | |.||||||.||
lekllgltllleefell.lslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvwe

QESAVIVMLTREEEAGKLKCHRYWPSDG---SRLYDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQ
| . ||||||...| |. ||..|||..|   |  |.|. |.|..| |..||..|.. ||... . ||.|..|..|.||| | |.|   |...| .|.|..
qnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkal

QQS-GNTCITVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
... .|. . ||||.||||||.|.|. .|......|| .||...|..|| ||| |||| .||.|.| .. |||
ealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

subfamily_Ptp69D_pd Subfamily Ptp69D 303-571 1.4e-83 275.5 In-house 19-287 (307) alignment
Range on Protein: 303-571
Range on HMM: 19-287/307.0
DPNIGTTYmdlEFERLTRDeRHPTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQ
|.. | .    |.|.| .    . . | .    || |||| .| ....||| |.  .|.  ||||||||| | .  | .|| |.||  | .|||||..||
dtdfglak...eyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeq

ESAVIVMLTREEEAGKLKCHRYWPSDGSRLYDKILVELTEELTYSDYVLRQFSLTHTEEKS-----SRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKW
|. .||||. ..|  . ||..||| .    |..|||.| .| . |||. |........|.|     || | |.. | |.||  ||.  ||..|| ||.. 
evtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrel

QQQSgNTCITVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLE
.... .. |.|||| ||||.|.| |...|....|||  .|.|.||..|| ||. .||  .||.|.|  . .| .
ykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss

0036941 (Phosphotyrosine protein) phosphatases II 304-575 6.5e-94 309.8 In-house 8-282 (297) alignment
Range on Protein: 304-575
Range on HMM: 8-282/297.0
PNIGTTYMDLEFERLtRDERHPTQFKSAMLSCNAAKNRYANILPYERTRVALhmrpGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQE
. ......  |||.|  .  ..  .. |.| .|  |||| .||||..||| |    .. ||||||||..|| .. ...||||.| | |.||||||.||| 
kllflalllkefeel.lpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqn

SAVIVMLTREEEAGKLKCHRYWPSD--GSRLYDKILVELTEELT--YSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQ
. ||||||...| |. ||..|||..  .|  |... |.|... .  ..||.||.. .|.|... ||.|..|..|.||| |.|||   |.|.| .|.|...
vtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlk

QS-GNTCITVHCSGGVGRTGVFCAVSILIERVK---AEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLESFDL
.. ... . ||||.||||.|.|.|. .......    || .|....|..|| ||| .||| .||.|.| ...|.| ....
llpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 306-570 5.6e-21 69.2 In-house 23-285 (302) alignment
Range on Protein: 306-570
Range on HMM: 23-285/302.0
IGTTYMDLEFERLTRDeRHPTQFkSAMLSCNAAKNRYANILPYERTRVALHMRPgevgSDYINASFIDGNHRLKAYIATQAPVPRTF---EDFWRMLWEQ
. |. .  ||...    . ...    .   | .||.  ..  .. ..| |...|     .|.||| ..  .  .  | .| |.  .    |.|||| ...
ldtaevkkefkkidtm.kvdlek.Ckafkknlkknqsedvpildsnlvkleaep....dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqe

ESAVIVMLTREEEAGKlKCHRYWP--SDGSRLYDKILVELTEeLTYSDYVLRQFSLTHTEEK--SSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVeKWQ
. . .|.| .|||  |   . ..|  |.    |.|. |       ...    ....    |    | ..    .| |...  |..   ||  . .|   .
kivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrk.VekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv.fak

QQSGNTCITVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
.....  . .    |.|| |.| .. . .|.....    . ..|. .| |||..|.. .|| . | ..  |.
kikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 307-578 5.1e-142 467.6 In-house 18-288 (318) alignment
Range on Protein: 307-578
Range on HMM: 18-288/318.0
GTTYMDLEFERLTRDERHPTQFKSaMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAV
|..... |.|||.|.|...|..|| . ..|.|||||||||.|..|||.|.|. ||.|||||||..|||..| |||||.|||.|.|.||||||.|||.|||
Gelllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsav

IVMLTREEEAGKLKCHRYWPSDGSRLYDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSGNTCI
|||||.|||.|| |.||||||.||| |.|. |||.||...||||||.|..|.|||..||.|||...|.|||.|.||||..|.||..||.|.||.||...|
ivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpi

TVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLESFDLYAN
.||||.||||||||.||.||.||.|||.|.||||||..|| ||..||||.|||||.|....|.|.|.|....
vvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevd

0043336 (Phosphotyrosine protein) phosphatases II 307-570 1.8e-92 305.0 In-house 18-277 (278) alignment
Range on Protein: 307-570
Range on HMM: 18-277/278.0
GTTYMDLEFERLTRDERhpTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAV
. | . ||||.|..       .. |.| .|  |||| .||||...|| |.. .|. .|||||||..|| .. ...||||.| | |.||||||.||. . .
lktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtt

IVMLTREEEAGKLKCHRYWPsDGSRLYDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQqSGNTCI
|||||...| |. ||..||| .||  |... |.|..| ...||..|.. .|.. .. ||.|.......||| |.|||   |.|.. .| .... . |...
ivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpv

TVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
 ||||.||||||.|.|. .|.|... || .|....|..|| ||| .||| .||.|.|  ..|||
lVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl

subfamily_PTPN23_pd Subfamily PTPN23 307-569 2.4e-70 231.6 In-house 13-279 (288) alignment
Range on Protein: 307-569
Range on HMM: 13-279/288.0
GTTYMDLEFERLTR-DERHPTQFKSAMLSCNAAKNRYANILPYERTRVALHmrpgEVGSDYINASFIDGNH-RLKAYIATQAPVPRTFEDFWRMLWEQES
|.| .| .|. |.. ....  ..  |.  ... |||. .||||...|| |.    .   |||||||. .       .|||||| . |  |||.|..|| |
gktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqks

AVIVMLTREEEAGKLKCHRYWPSD--GSRLYDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEK---WQQ
 |||||. .|| || |..||||.|   .  .... | | .. . . .| |...|.. ...  . |.  | | ||. |.|.|   |......||.    .|
sviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavq

QSGNTCITVHCSGGVGRTGVFCAVSILIERV-KAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEY
.  .| . |||| ||||||||. |   .. . | .||.|. | |..|| ||  |||.|.|..|.|  . |.
rksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 308-571 1.5e-71 235.8 In-house 18-278 (315) alignment
Range on Protein: 308-571
Range on HMM: 18-278/315.0
TTYMDLEFERLTRDErhPTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVI
|. .  ||  |   .  . . ..|  . |  |||| ||||....|| | .   .  |||||||.| . .  |||||.|.| . . .|||||..... . |
talfseefhdlpdPd..iyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvtti

VMLTREEEAGKLKCHRYWPS--DGSRLYDKILVELTEELTYSDYVLRQFslTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWqQQSGNTC
||.|  .|  |.|| .|||     |  . .| ||| .  . .| | |..  .  . ..|| | ||| |.||| | ..    |. || .|    ... .  
vmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefs

ITVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLE
. |||| |||||||....   ....| .  .|||..|. || .|| .|||...| | | ...|.| 
llvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll

subfamily_PTPN14_pd Subfamily PTPN14 308-571 7.2e-62 204.1 In-house 22-297 (300) alignment
Range on Protein: 308-571
Range on HMM: 22-297/300.0
TTYMDLEFERLTRDERhPTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEvGSDYINASFIDG--NHRLKAYIATQAPVPRTFEDFWRMLWEQESA
 . .  |.||... .   .....| |  || |||. ..|||| .|| |     .  ..||||| |      . . ||..|.|.. | .|||.|.|||. .
egkvfteyeripkkre.dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvq

VIVMLTREEEAGKLKCHRYWPSDGSR----LYDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQS
.|||||.||| || |...|.|...|.     ..|  |      . . .. ... | |   |  | |  .| ||||| |.||   | .. . .|.  ....
livmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrkt

GNTC--------ITVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLE
 ..         . |||| |||||||   . .||. .. .  ||. .....|| ||  .|||  ||.| |... .||.
nseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 308-570 1.1e-38 128.0 In-house 15-277 (307) alignment
Range on Protein: 308-570
Range on HMM: 15-277/307.0
TTYMDLEFERLTRdeRHPTQFKSAMLSCNAAKNRYANILPYERTRVALHMrPGeVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVI
 . .  ||. |..  . |       .|.|. |||| ..   ...|. ... .| . |||| | ..    . | .|..| |   |  .|| |  ...   .
vqalvdefrvlak..ktpegvtveafsantdknryqdvkcqdkgrivvkf.dg.lasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesv

VMLTREEEAGKLKCHRYWPSD-GSRL-YD----KILVE-L-TEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQq
.|| .  | .|.||..||| . | .| .      | |. | ...|.  . ..   .|     . || ....| ..||| | |.  .. |.|.  |.  . 
imlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydt.

qsgnTCITVHCSGGVGRTGVFCAVSILIER-VKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
      . |||| ||||.|   |.|.. .. .. .   |. . |. || ||.  .||. || . .  . ||.
....npvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf

0040438 (Phosphotyrosine protein) phosphatases II 309-573 1.2e-95 315.7 In-house 18-279 (317) alignment
Range on Protein: 309-573
Range on HMM: 18-279/317.0
TYMDLEFERLTRDERHptQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIV
|..  |||.| .   .   .. |.| .|  |||| .||||...|| |.  .|  .|||||||..|| .. ...||||.| | |.||||||.||| . |||
talleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtviv

MLTREEEAGKLKCHRYWPSDGSRLYDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQqSGNTCITV
|||..|| |. ||..|||....  |... |.|..| ......||.. ....... ||.|..|..|.||| |.|.|   |.|.. .|..... ...... |
mLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlV

HCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLESF
|||.||||||.|.|. ...|... || .||...|..|| ||| .||| .||.|.|. ..|||  .
HCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk

0045450 (Phosphotyrosine protein) phosphatases II 309-570 1.1e-89 296.4 In-house 27-304 (307) alignment
Range on Protein: 309-570
Range on HMM: 27-304/307.0
TYMDLEFERLTRDERH-PTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGE-VGSDYINASFI--------DGNHRLKAYIATQAPVPRTFEDFWRM
| .  |||.| . . . .  ...|.| .|  |||| .||||..||| |.  .|.  .|||||||..        || .. ...||||.| | |.||||||
tgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrm

LWEQESAVIVMLTREEEAGKLKCHRYWPSDGSR-LYDKILVELTEELTYSDYVLRQFSLTHT-EEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEK
|||| . ||||||...| |. ||..|||..|.   |... |.|..| ....|..|.. .|.. ... ||.|..|..|.||| |.|.|   |.|.| .|.|
lweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrk

WQQQS-GNTCITVHCSGGVGRTGVFCAVSILIERVKAEGL---IDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
..... ..... ||||.||||||.|.|  ........||    .|....|..|| ||| .||. .||.|.|  ..|.|
aleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 309-567 2.6e-81 267.8 In-house 21-276 (288) alignment
Range on Protein: 309-567
Range on HMM: 21-276/288.0
TYMDLEFERLTRDERHPTQfKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIV
| .  |.. |.  |.. .. . . |. || |||| |||||. .|| |.  . | |.||||||.|||... |.|||||.|.. | .|||.. .|...  ||
tgfseeynsLaalektksv.tagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstiv

MLTREEEAGKLKCHRYWPSDGS-RLYDKILVELTEELTYSDYVLRQFSLThtEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSgNTCIT
|||   | || ||..|||...  ..| .. |.|.|. .  |.|||.. |    .|. . . |.| . ||| | |||   |..|. ||.  .|.     |.
mltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.tgpii

VHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQ
|||| ||||||.| |.  ||..|..|  |||. ||..|| ||. .|||. ||||.| .. 
vhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 309-568 1.1e-76 253.3 In-house 34-289 (319) alignment
Range on Protein: 309-568
Range on HMM: 34-289/319.0
TYMDLEFERLTRDERHPTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIV
| .  || |...     .. . | |  |  |||. |||......| |.   || .||||||||..|  | . |||.| | . | .|||||.||.... ||
tklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstiv

MLTreeeagKLKCHRYWPSDGSRLYDKILVELTEELTYSDYVLRQFSLTH-TEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQ-QSGNTCI
.||      | || .||| ..   ...  |...     ..||.|.. |.. ..||  | ..||    ||| | |.... |. |. .|.. .. . ... |
llt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhrani

TVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQE
 |||| |||||||. .. .|..|.| |  .||...|. || ||. .||   || |.|... |
vvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 309-571 5.4e-70 230.9 In-house 18-277 (515) alignment
Range on Protein: 309-571
Range on HMM: 18-277/515.0
TYMDLEFERLTRDERHPTQfkSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIV
| .  ||  |   . .|     |    |  |||| |||||...|| | .   .  |||.|||.| . .  |||||.|.| . . .||||...... . |.
tlfseefhdlpgpniypqt..vaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttia

MLTREEEAGKLKCHRYWPS--DGSRLYDKILVELTEELTYSDYVLRQFSLTHTEEksSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSGnTCI
|.|. .|  | || .|||     |  . .| |||    . .. . |.. ... ..  || | ||. |.||| | |.    |. || .|   ..|     .
mvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpl

TVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLE
 .||| |||||||....   . ..|    .|||..|. .| .|| .|||..|| | | ...|.| 
iihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 310-571 8.3e-67 220.0 In-house 11-278 (287) alignment
Range on Protein: 310-571
Range on HMM: 11-278/287.0
YMDLEFERLTRDE-RHPTQFKSAMLSCNAAKNRYANILPYERTRVALHmRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIV
 .| |...|..|    .  ||.|    .. |||||..||.. ||| |    || ||||||| .. . .. .|.||.|.|.. |  ||||...|..||...
dvdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvi

MLTREEEAGKLKCHRYWPSDG--SRLYDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQV----EKWQQQSG
..||| | ..|||..|||      |.    .| |  .    .|  | . | . | . .|.|.|..  .||| .|. . |||| .. .|    |  .. |.
tmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardase

NTCITVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLE
   . ||.. |.||.|.. |. .|..| .  | .|| ..| .|| .| |.||.  |. . | ..  | .
vGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 310-578 8.9e-63 206.8 In-house 16-301 (301) alignment
Range on Protein: 310-578
Range on HMM: 16-301/301.0
YMDLEFERLTRDERHPTQFKsaMLSCNAAKNRYANILPYERTRVALHMRPG--EVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVI
 .. ....|.. | .... .  . . |.| ||. || .|.  |. |.  |       .|||||.|||  . |..||.|.|. .|  ||||..|..  . |
kfeeqykelkegedksctvg..lseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsi

VMLTREEEAGKLKCHRYWPS--DGSRLYDKILVELTEELTYSDYVLRQFSL---------------THTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDL
||.| ..|  | ||..|||.    |  . .. |.|..| .| |.|.||...                 ...|||. | |.| ||||. |.       .  
vmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqv

IGQVEKWQQQSGNTCITVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLESFDLYAN
| .| . ||. |   . |||| .|.|.||.|.||| .| .|||| .|||| .. .| ..| .|.| .|| . |  |..||.  . |||
iddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan

subfamily_PTPRG_pd Subfamily PTPRG 311-572 6.3e-82 270.6 In-house 21-289 (563) alignment
Range on Protein: 311-572
Range on HMM: 21-289/563.0
MDLEFERLTRDERHP-TQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGS-DYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIV
.. ||| |..   .   . ...   .|  |||| ||..|.|.|| |.  ||. .. |||||..||| .. ||.|||| |.. ||.|||||.|||..|.||
fseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiiv

MLTREEEAGKLKCHRYWPSDGSRLYDKILVELTEELTYSDYVLRQFSLTHTE--E----KSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQsG
|.|  .| |. ||..|||.|.|  |... | |.|| . . |  |.... ...  .    .. . |||...|.||| | ||. .  .  . . .. ...  
mitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaanka.e

NTCITVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLES
   |.|||| ||||||...... |......|  ..||....|.|.||. .|||..|| | . ...| . |
aGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias

subfamily_PTPRN_pd Subfamily PTPRN 311-569 9.4e-67 219.8 In-house 31-291 (297) alignment
Range on Protein: 311-569
Range on HMM: 31-291/297.0
MDLEFERLTRDERHPTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFI-DGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVM
.. |.| |.. | .|.  . |    |. |||....|||. .|| |. .  .  |||||||.| | . |  ||||||.|.. |  |||.|.||| ..|||.
lekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivn

LTREEEAGKLKCHRYWPSDGSRLYDKILVELTEELTY-SDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQsGNTCITV
||| || |  .|.|||| .|| .|.   |.|  |  .  ||..| | |   . . .| | ||    ||..| | |   |...  .|.|  .    . | |
ltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG.rscpivv

HCSGGVGRTGVFCAVSILIERV-KAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEY
|||.|.|||||.... ....|. |    ||.  |..||| ||| .|.||||.||..|.. | 
hcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 311-568 1.8e-60 199.3 In-house 8-264 (283) alignment
Range on Protein: 311-568
Range on HMM: 8-264/283.0
MDLEFERLTRDERHPTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGevgsDYINASFID---GNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVI
..| .|.| |    . . . |. . |  |||. .|.|... || |.  .     |||||.||     ... | ||..|.|. ||  |||.|..... . |
nklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitai

VMLTREEEAGKLKCHRYWPSDGSRLYDKILVELTEELTYSDYVLRQFSLTHT-EEKSSRIVRQFQCTDWPDSGlPESGVGLIDLIGQVEKWQQQSGNTCI
||||.  |  . || .|||..||  | .  | | .| |   .. ... | .    ||. ..  .|  || . | ... .  .  . .|   |..| .. |
vmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleyg.eqaiinslvkfnkvislqteskkgPi

TVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQE
 |||| |.|||.||.|.|  .. ...| ..|||..|. .| ||. .|||.||| . .. . |
vvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 311-570 2.9e-50 165.8 In-house 22-236 (392) alignment
Range on Protein: 311-570
Range on HMM: 22-236/392.0
MDLEFERLTRDERHPTqfKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVML
.  ||  |   . .|.  ..|    |  |||| |||||...|| | .      |||.|||.|.. .  |||||.|.| . ...|||||..... . |.|.
ffeefhdlpgpdiypq..tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamv

TREEEAGklkchrywpsdgsrlydkilvelteeltysdyvlrqfslthtEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKwQQQSGNTCITVHC
|. .|.                                             .. | | ||. |.|||...|.    |. .| .|.  .  .    . .||
tklkegd..........................................kgddartvaqfhftewPdkdvpkhtssllkfikevka.dfGqythpliihc

SGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
| |||||||  ..  .. . |   ..|||. |  .| .|| |||||.|| | | .. | |
sagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 311-571 6.9e-44 144.9 In-house 8-260 (267) alignment
Range on Protein: 311-571
Range on HMM: 8-260/267.0
MDLEFERLTRDERHPTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEvgsdYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVML
.. ||| ...     ..    . . |...||. . |||. ||| |  .  |    |||||...| .. .|.|.|| |.  |  ||. .. .|. .|||.|
iekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivll

TReeeAGKLKCHRYWPSD--GSRLYDKILVELTEELTYSDYVLRQFSLTHTEEkSSRIVRQFQCTDWPDSGlpESGVGLIDLIGQVEKWQQQSGNTCITV
|.   ... . ...||     .. |. . || . |    || .  . |   .| |.. |  .    |      .    |  |.| . | | . ||  . |
tk...vftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfkne.sahnvtlyyykkwnint..nnkpylkplfgilaknqlengnrPlvv

HCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLE
.|| ||||.| |  .   .||.| ||  |.|. ....| ||...|.||..| ... .. || |
acsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyae

0046845 (Phosphotyrosine protein) phosphatases II 312-578 2.4e-96 317.7 In-house 3-282 (284) alignment
Range on Protein: 312-578
Range on HMM: 3-282/284.0
DLEFERLTRDERHPT-QFKSAMLSCNAAKNRYANILPYERTRVALHMRPGE-VGSDYINASFIDGN-----HRLKAYIATQAPVPRTFEDFWRMLWEQES
. |||.|..   ... ... |.| .|  |||| .||||...|| |.. .|.  .|||||||..||      .. |..||||.|.| |.||||||.|||..
eeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnv

AVIVMLTREEEAGKLKCHRYWPSDG-SRLYDKILVELTEELTYSDYVLRQFSLTHTE-EKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQ-S
 ||||||...| |. ||..|||..| .  |... |.|..| ...||..| ..||... .. ||.|..|..|.||| | |.|   |.... .|...... .
rvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlp

GNTCITVHCSGGVGRTGVFCAVSILIERVKAEG---LIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLESFDLYAN
|.  | ||||.||||||.|.|. .|.|....||    .||...|..|| ||| |||| .||.|.| ...||| ..  ...
gggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltlle

subfamily_PTPRB_pd Subfamily PTPRB 312-571 8.8e-85 279.3 In-house 28-286 (293) alignment
Range on Protein: 312-571
Range on HMM: 28-286/293.0
DLEFERLTRDERHpTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLT
  |.|.|   ... .. |.| |..|.||||| |||||. .|| |.   .| |||||||..|.|..  . .|||| |.| |..|||||.||..| .|||||
seeyeelkavgkd.qavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmlt

REEEAGKLKCHRYWPSD-GSRLYDKILVELTEELTYSDYVLRQFSLTHteEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQ-QQSGNTCITVH
.  | || ||..|||.|  . || .| |.|..| ...|.|.|......  ||..| |||.. | ||| | ||.   |.|.. .|.... ... .. |.||
qlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvh

CSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLE
|| ||||||.| |.  |..... | ..|.| .|..|| .|  .|||..|| | .......|.
CsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 313-574 9.3e-85 279.4 In-house 26-287 (305) alignment
Range on Protein: 313-574
Range on HMM: 26-287/305.0
LEFERLTRDerhPTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTR
 ... |...   .....    . |.||||...| ...  |. |  .. .  |||||||..|| .| |.||..|.|.. | .||||...|    .|||||.
aqykslyee...eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltk

EEEAGKLKCHRYWPSDGSR--LYDKILVELTEELTYSDYVLRQFSLTH-TEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSGNTCITVH
  | || ||..|||   ..   .... |||..| |.|||. |.....   |.| || | |.| ||||| | |..   |..|| .|.| |... .. ..||
lveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVh

CSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLESFD
|| ||||||||.||.| .||.|.|. .|||. ...|| .|. ||||.||| |..  ..|.....|
CsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 313-576 1.1e-77 255.8 In-house 24-289 (290) alignment
Range on Protein: 313-576
Range on HMM: 24-289/290.0
LEFERLTRDERHPTqFKSAMLSCNAAKNRYANILPYERTRVALHMRPGE--VGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVML
 .|..|   |.. |  . .. | |  .||.|||..|.  |. |.  .|.     .||||..|.| .  |.|||||.||..|  |||...|......||||
nqfkmldsgeseht.vtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivml

TREEEAGKLKCHRYWPSDGSRLYDKILVELTEELTYSDYVLRQFSLTHTEE-KSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSGNTCITVH
| . | || ||. |||. ... |... ..|..| |...|. |......... .....| |.| | |.. |  .   . . .| ...| | ..||| | ||
tniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvH

CSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLESFDLY
||..|||..||||. . |...| || ||||| ....| |.| .|||..||.. .. . .||.||. |
CSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 313-568 3.4e-75 248.2 In-house 2-253 (284) alignment
Range on Protein: 313-568
Range on HMM: 2-253/284.0
LEFERLTRDERHPTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTr
 || |...     |. . | |  |  |||. .||......| |.   || .||||||||| |  | . ||||| | . | .|||||.||.... ||.|| 
vefrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.

eeeagKLKCHRYWPSDGSRLYDKILVELTEELTYSDYVLRQFSLTH-TEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQ-QSGNTCITVHC
     | || .||| ..   ...  |...     ..||.|.. |.. ..||  | .|||    ||| | |.... |. |. .|.. .. . ... | |||
.....kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhc

SGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQE
| |||||||. .. .|..|.| |  .||...|. || ||. .||   || |.|... |
sagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_PTPN3_pd Subfamily PTPN3 313-570 3.4e-67 221.3 In-house 19-276 (280) alignment
Range on Protein: 313-570
Range on HMM: 19-276/280.0
LEFERLTRDERHpTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPgeVgsDYINASFID----GNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIV
 .||.| | ..   . . | .. |..|||| .||||. ||| |.  .  .  |||||....    ...  . ||||| |...| .|||.|.|||.| .||
aqfeqlyrkkpg.laisaarkpenlsknryrdilpydatrvklkese..t..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssliv

MLTREEEAGKLKCHRYWPSDGSR-LYDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQqSGNTCIT
|||   | |. |||.|||. . .  | .. |....| . . ||||.. |...|.| .| . |.| ..|||.|.|..   ..... .|.| .. . .. . 
mlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrs.gkeePvv

VHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEF-CYTTIQEYL
||||.|.|||||. .. . .  . |.  . . . |...| || ..|||..||.| | .... | 
vhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvye

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 314-574 1.1e-98 325.2 In-house 28-287 (319) alignment
Range on Protein: 314-574
Range on HMM: 28-287/319.0
EFERLTRDERHptQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTRE
||. |   .    .|.||    |  |||| |||.|.||||.|   .|  |||||||||||| .. ...||||||.  |.||||||.||.|| ..||||. 
efkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltkl

EEAGKLKCHRYWPSDGSRLYDKILVELTEELTYSDYVLRQFSLTHTEEKS-SRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSGNTCITVHCSG
 | .|.|...|||.     | ...|.| ||   .||. |...| .  ..  .| | .|| |.||| . ||.. .|.||.....| .... .  |.|||| 
veklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsa

GVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLESFD
|||||| |..... .|||| ||..|||.||..||.||. |||...||.|.| .. |..|..|
GvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd

DSPc_SM00195 314-570 1.1e-90 299.0 In-house 5-262 (263) alignment
Range on Protein: 314-570
Range on HMM: 5-262/263.0
EFERLTRDERHPtQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTRE
|||.| . . .  ....|  . | .|||| |||||..||| |. .... |||||||..|.|... |.|||||.| | |.|||||| ||... .|||||.|
efekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmltee

EEAGKLKCHRYWPSD--GSRLYDKILVELTEELTYS-DYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSgNTCITVHC
|| || ||.||||..  |.  ..|| |.|.|. ... ...||...||..... .| |.|.|...|||.|.|.|   ...|. .|.|....| .. | |||
eengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhC

SGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
| ||||||.|....|.......|  .|.|..|..|| ||| ||||..|| |.|..| ||.
saGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 314-570 1.1e-90 299.0 In-house 5-262 (263) alignment
Range on Protein: 314-570
Range on HMM: 5-262/263.0
EFERLTRDERHPtQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTRE
|||.| . . .  ....|  . | .|||| |||||..||| |. .... |||||||..|.|... |.|||||.| | |.|||||| ||... .|||||.|
efekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmltee

EEAGKLKCHRYWPSD--GSRLYDKILVELTEELTYS-DYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSgNTCITVHC
|| || ||.||||..  |.  ..|| |.|.|. ... ...||...||..... .| |.|.|...|||.|.|.|   ...|. .|.|....| .. | |||
eengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhC

SGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
| ||||||.|....|.......|  .|.|..|..|| ||| ||||..|| |.|..| ||.
saGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_PTPN9_pd Subfamily PTPN9 314-570 1.3e-82 272.2 In-house 21-290 (297) alignment
Range on Protein: 314-570
Range on HMM: 21-290/297.0
EFERLtRDERHPTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTRE
|.. . |.|    .|. ..| .|  ||||...| |..||| |  ....  ||||||.|.|| .. ||.|||| |...|..|||||.||||  |||| || 
eyaei.rnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrv

EEAGKLKCHRYWP--SDGSRLYDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEK------------WQQ
.| |.||| .|||  .. |  . .. |.  |  ...||. |.. ....... || |  || . ||| | |.|.  |.|.. .| .            |. 
vergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkg

QSGNTCITVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
.  .  | |||| |.|||| |... | ..|.. .| .||..||..|| ||  ..|| .|||||| .. || 
hpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 314-571 4.1e-78 257.3 In-house 20-277 (281) alignment
Range on Protein: 314-571
Range on HMM: 20-277/281.0
EFERLTR-DERHPTQfkSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTR
|.| |.  . .....  ..    |  |||| ||  |. ||| ..    .  .|||||.|..| .  |.|||||.||| ....||.|.|||.  .|||.||
eyeklaaigvdntat..askadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtr

EEEAGKLKCHRYWPSDG-SRLYDKILVELTEELTYSDYVLRQFSLtHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSGNTCITVHCS
| |||||||||||| |  .  | .. |. |.| . . |. |.|.| ..|.  .| |.|.. | ||| | |..   |..   .|.| .... .. . .|||
eieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCs

GGVGRTGVFCAVSILIERVKAE-GLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLE
 ||||||.. |.  |...|.||   .|| ..|..|| .|  ||||  |||| | .. ..|.
aGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 315-571 2.3e-59 195.6 In-house 1-265 (270) alignment
Range on Protein: 315-571
Range on HMM: 1-265/270.0
FERLTRDERHPTQFKSAmlSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDG-NHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTRE
|..|...| ..... .|    ... ||||.|||  .||| |.    .  . |||| .. | ... |.|||...|.| | ..||||.||...  |||.|  
fkeldkeetsesdlpea..argkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgl

EEAGKLKCHRYWPSDGSR----LYDKILVELTEELTYSDYVLRQFSLThTEEKSSRIVrQFQCTDWPDSGLPESGV------GLIDLIGQVEKWQQQSGN
|| |. || ||||..  .     . || |  ..|   . |.|..  |. .. .. |.|  |. ..||| | |..         |. .. .| .....  .
eEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle.ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldk

-TCITVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLE
 . . |||| ||||||.. |. | .. .. .. .|| . ...|| .|.|.||. .|||| | ...|| |
aePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae

subfamily_ptpA1_pd Subfamily ptpA1 317-530 5.3e-43 142.3 In-house 28-256 (418) alignment
Range on Protein: 317-530
Range on HMM: 28-256/418.0
RLTRDERHPTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRlKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEA
||  .   |..        |..||||.|||| ..||| |.    . ||||||| .||| .  | .|.|| |.| |  |||||.||.   .||||.|| | 
rlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsresen

GKLKCHRYWPS-----------DGSRLYDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQ-----
 ..|| ||||            .|  ..    ||| | .   .  .    .  | |  .| . |.|   |||  .|.    . .|.  . . |.|     
crikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipss

SGNTCITVHCSGGVGRTGVFCAVSILIERV
  |  | |||| |||||| ||.  |.....
drnvpiivhcsagvgrtgtfctavimmkkl

0045098 (Phosphotyrosine protein) phosphatases II 320-571 7.5e-85 279.9 In-house 17-273 (278) alignment
Range on Protein: 320-571
Range on HMM: 17-273/278.0
RDERHPTQFKSAMLSCNAAKNRYANILPYERTRVAlhmrpgevgsDYINASFIDGNhRlKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKL
.   .| ..  |.. .|..|||| .||||...||           ||||||.|||  . |..||||.| | |..||||||||. . ||||||...| |. 
lllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy.p.kkfIatqgPlpstvadfwrmlwelgitvivmltelvelgre

KCHRYWPSDGSRLYDKILVELTEELTYSDYVLRQFSLTHT----EEKSSRIVRQFQCTDWPDSGLPESG--VGLIDLIGQVEKWQQ------------QS
||..|||..||  |... |.|..| ...||.|| . .|..    |.  || |...... ||| | |..     ...|. .......            ..
kcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllld

GNTCITVHCSGGVGRTGVFCAVSILIERVkaEGLIDVFQTVQHLRLQRPA-MVQTKDQYEFCYTTIQEYLE
..... |||| ||||||...|. ...|..  || .|....|..|| |||  .||...||.|.|  ..|.|.
sggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll

subfamily_PTPN12_pd Subfamily PTPN12 320-571 8.1e-81 266.1 In-house 26-278 (290) alignment
Range on Protein: 320-571
Range on HMM: 26-278/290.0
RDERHPTQfkSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKL
... ..|.  ..  . | .|||| .||||. .|| |.   .| |||||||.|| | .  ..|||.|.|.|.| .|||||.||..  ..||. || | || 
aekvyste..agekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkk

KCHRYWPSD-GSRL-YDKILVELTEELTYS-DYVLRQFSLTHTeeKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQqSGNTCITVHCSGGVGR
||.||||.  ...| .... |.|.|| . . |...|.. ...   | ||.|.||. |.||| | |.|   |..|| .|.. |. | .. . |||| ||||
kCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGr

TGVFCAVSILIERVKAEGL---IDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLE
||. .|. .  | .||| .   .|||. |..|| ||.|.||||.|||. | .. |...
tGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 320-483 1e-32 108.2 In-house 17-182 (297) alignment
Range on Protein: 320-483
Range on HMM: 17-182/297.0
RDERHPTQFKSAMLSCNAAKNRYANILPYERTRVALhmRPGEVGSDYINASFI---DGNHRLKaYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEA
 ||... .| ||  .    |||| .|| .. ||| |  . .  ..||||| ..   | .. || || .| |. .| .|||....||.  ||||... .| 
ldeargesfssakrnsslrknryrdilatddtrvkl..lrviterdyinadyvvfpdeeadlk.yilaqGplsatvddfwtlvaeqdvrvivmvaklqed

GKLKCHRYWPS-DGSRL-YDKILVELTEELT--YSDYVLRQFSLTHTeeKSSRIVRQFQCTDWPDSGLPES
|. ||  |||| .. ||   ...||   . .  .   .| .. | .   . || ||  |   ||| |.|  
Grdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsd

subfamily_PTPN1_pd Subfamily PTPN1 321-568 1.3e-54 179.9 In-house 17-269 (290) alignment
Range on Protein: 321-568
Range on HMM: 17-269/290.0
DERHPTQFKSAMLSCNAAKNRYANILPYERTRVALHMRpgEVgsDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLK
.| .  . ..| |  | ..||| .. ||. .|. |.    ..  ||||||... ..  . || || |.|.| . ||.|.|||.|  .||| .  | ...|
keasdfptreaklpenrnlnryrdvspydhsriklera..dn..dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqik

CHRYWPSDGS---RLYD--KILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSGNT-CITVHCSGGV
|..|||.. .    |..  |. |.| .| ..| |..|.. |.  . . .| . .|  | ||| |.|||   ..... .| .    | .     .||| |.
caqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGi

GRTGVFCAVSIL---IERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQE
||.| || |  .   ||. .    .|. ... .|| .|  ..||.|| .| |..| |
GrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 321-566 2.6e-20 67.7 In-house 4-255 (290) alignment
Range on Protein: 321-566
Range on HMM: 4-255/290.0
DERHPTQFKSAMLSCNAAKNRYANILpYERTRVALHMRPGEVGSDYINASFIDGNHRLKaYIATQAPVPRT-------FEDFWRMLWEQESAVIVMLTRE
 |   . .|. ..  .. ..|... |  | |||.|.       .||| |...   . |.  |.||.|  ..        |.|| |  . ..  .|||   
kestavllktdyvkkhemdqRlevpL.veatrvvLkgygkrfnddyiHAnrvtcpnglr.liltqsPqekitekrnStiekfwwmakqEkvkqvVmlcef

EEAGK----LKCHRYWPS--DGSRLYDKILVELTEELTYSDYVLRQFSLTHTEEKSSRiVRQFQCTDWPDSGLPESGVGLIDLIGQVEkwqqqSGNTCIT
||  .      | .| |   ...  .. . |. ..  .  |   |.  ... .|.    |   .  .| ..  .|.   |..|| .|.       .| . 
eeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeeft.vtHsllkgWnklnvqedtktllsliqkvk.....asktpvi

VHCSGGVGRTGVFCAVSILIERVK-AEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTI
|||  |. |  .. |. .    .   .| . . . .. || ||  ..... .. |    |
vHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagi

subfamily_PTPRD_pd Subfamily PTPRD 323-575 3.1e-120 397.5 In-house 35-286 (564) alignment
Range on Protein: 323-575
Range on HMM: 35-286/564.0
RHPTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCH
.. .....|  ..| ||||||||..|...|| |.. .|. |||||||||||| .. |||||||.|...|.||||||.|||.|..|||||. || || |||
gqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkch

RYWPSDGSRLYDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQqQSGNTCITVHCSGGVGRTGVFCA
.|||..|.  |... |.|.|| ...||..|.|.|.......|| ||||. |.|||.| |||. .|.||| .|.... .... .|.|||| ||||||.|..
kYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfiv

VSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLESFDL
.....||.|.|...|..|.|..|| ||.|||||..|| |....|.|.|.... 
idamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnt

subfamily_PTPN13_pd Subfamily PTPN13 323-572 4.2e-71 234.4 In-house 24-271 (273) alignment
Range on Protein: 323-572
Range on HMM: 24-271/273.0
RHPTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGevgsdYINASFIDG--NHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLK
.   . ...    | .|||| |.|||..||| |    |     |||||.|    ..    |||.| |.| | .|||.|.|||.. ||.|.| | | ||.|
kpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvk

CHRYWPSDGS---RLYDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQqsGNTCITVHCSGGVGRT
||||||.  .    ..... ||| .   ....|.|.. ....| . || | ... ..||| | | | . |. .. .| . |.   .. | |||| |.||.
chrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrs

GVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLES
|.. .. .... .. .  .|| ..|..|| || ..||||||| |.| .| | |.|
Gtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlks

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 323-568 4.9e-70 230.9 In-house 38-277 (315) alignment
Range on Protein: 323-568
Range on HMM: 38-277/315.0
RHPtqFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCH
 ||  .. |  . |  |||| ||..|...|| | .   . .|||.||.||||  . . |||.|.| . . .||||...|.. . |||||   |  | |. 
lhp..ldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkae

RYWPSDgSRLYDKILVELTEELTYSDYVLRQFSLTHTEekSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSGnTCITVHCSGGVGRTGVFCA
.||| .   .| || | . .|  ...|  | .| .  .    | | |.. | |||.|.|.. . |..|| .| .....|  . | |||| |||||| |..
kywpdk.kviyGkitvtrkseevnteytvrtlsvvfgd..nirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfit

VSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQE
.. ......|| .|||.. .. .| .|  |||. .||.| | .. |
ldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 323-376 2.1e-10 34.6 In-house 27-78 (244) alignment
Range on Protein: 323-376
Range on HMM: 27-78/244.0
RHPTQfKSAMLSCNAAKNRYANILPYERTRVALHMRPGEvGSDYINASFIDGNH
|.  |  .|.||.||.|||| ||||.. ||| |     | |||||||..|.|..
reflq.tnavlsanatknryinilpfdetrvilssskke.gsdyinanyiqgsq

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 323-408 1.5e-09 31.9 In-house 24-114 (347) alignment
Range on Protein: 323-408
Range on HMM: 24-114/347.0
RHPTQFKSAMLSCNAAKNRYANILPYERTRVALH-----MRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIV
  |..| |.    . .|||  .    . ||| |      . . .    ||||| |  .   | || || |.| |  |||.|.     . .|
yspskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvv

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 324-572 2.9e-66 218.8 In-house 36-290 (325) alignment
Range on Protein: 324-572
Range on HMM: 36-290/325.0
HPTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLtREEEAGKLKCHR
 .  .| ||.  | ||||. |.......|| |  .  .  |||||||..  . . . ..|.||| . | .|.||.. . ...|.|.|  | . || .|  
dgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvl.neldlgkdrcav

YWPSD--GSRLYDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQ-----QSGNTCITVHCSGGVGR
||| .   |. .  . |.|    ..|||| |.. .  ...  .| |.|||   |.| | ..    || ..  |.. ..       . | | |||| ||||
ywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGr

TGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLES
|||| ..  ....|  |  .|.|. |..|| .||.||.| ||| ..|... |.. |
tGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveayms

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 325-570 9.4e-18 58.8 In-house 36-279 (303) alignment
Range on Protein: 325-570
Range on HMM: 36-279/303.0
PTQFKSAMLSCNAAKNRYANILPYERTRVALHmrpgevGSDYINASFIDGNHRLKAyIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRY
| .     .  |  |||.....  . ..| |        | || ||... . . || | || |.. |  |||.|. ||   ....|  . |  ||  .  
ppsvsknqfvknmdknrfvdvicldhskvkls......dssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsv

WPSDGSRL--YDKI-LV-ELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQctDWPDSGLPESG-VGLIDLIGQVEKWQQQSGNTCITVHCS-GGVGRTG
.| .   |   ..   | |. .      .||.  |..  . ||   | ...  .|| . .|  |   ..  | |..   ..  ..  ||. |  |.||.|
fprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhyk..awphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgrag

VFCAVSILIERVKAE-GLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
 |.        ...|   .|. . .. .|  |   ||   |. . || . |..
tfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv

subfamily_egg_pd Subfamily egg 326-567 5.8e-26 85.9 In-house 30-267 (307) alignment
Range on Protein: 326-567
Range on HMM: 30-267/307.0
TQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAgkLKCHRYW
  .. |. . |  | |   .   . .||.|..| |    |.| |  ..|.  |  .| .|||.  | .|||||....|   |||||   |.   .|. ||
islttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyyw

PSDGSRLY----DKILVELTEELTYSDYVLRQFSLTH-TEEKSSRIVRQFQcTDWPDSGLPESGVGLIDLIGQVekwqqqSgnTCITVHCSGGVGRTGVF
|   |         . .|  .    .| ..|   |     ..  | .  .|  |.  |.   | . .. .. ..      |  . . |..  || .....
pkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwq.gdvnnssdvysplrvlrklrnl......s..kpvvvqdilGvskaatl

CAVSILIERVKAEGL--IDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQ
 |. | .  .    .    | ..|. |||.|.  |..  .| | |  . 
vaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl

subfamily_PTPRA_pd Subfamily PTPRA 328-570 2.9e-94 310.7 In-house 50-295 (330) alignment
Range on Protein: 328-570
Range on HMM: 50-295/330.0
FKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPS
.. |    |  |||. |||||. .|| | .. |.  ||||||||||| .. . .||.| |  .| ||||||.|||.|| |||||  .|  . ||..|||.
lelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPd

DGSRLYDKILVELTEELTYSDYVLRQFSLT----HTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSGNtCITVHCSGGVGRTGVFCAV
.|.  | .| ||. .|    || .|.| ..    .|.||.||.||||  | ||| |.|  ..|...|. .|.| .|||..  |.|||| |||||| |...
eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivl

SILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
. ..||||||...|||..|..|||||| ||||. ||||.| ...|| 
davlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy

0040439 (Phosphotyrosine protein) phosphatases II 328-570 4.1e-87 287.1 In-house 3-246 (249) alignment
Range on Protein: 328-570
Range on HMM: 3-246/249.0
FKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPS
.. |.| .|  |||| .||||...|| |.  ||  .|||||||.||| .. ...||||.| | |.|||||||||. . ||||||...| |. ||..|||.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

DGSRLYDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQS-GNTCITVHCSGGVGRTGVFCAVSIL
.||  |... |.|... ...||..|.. ||......|| |...|.||||| |.|.|   |.|.| .|.|....   .... ||||.||||||.|.|  ..
ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm

IERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
.|... |. .|....|..|| ||| .||. .||.|.|  ..|.|
leqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

0042113 (Phosphotyrosine protein) phosphatases II 329-571 5.4e-87 286.5 In-house 2-244 (245) alignment
Range on Protein: 329-571
Range on HMM: 2-244/245.0
KSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSD
..|.| .|  |||| .||||..||| |   .|. .|||||||..|| .. . .||||.| | |.|||||||||. . .|||||.||| |. ||..|||..
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

GSRLYDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSGNTCITVHCSGGVGRTGVFCAVSILIE
.|  |... |.|..| ...||..|....|.. .. || |.......||| | |..   |.|..  |.|......|. . ||||.||||||.|.|. ...|
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

RVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLE
....|. ......|..|| ||| .||| .||.|.|  ..|.|.
qlekelgvsleeavkelrsqRpgavqtpsqyrflyeallellk

subfamily_PTPRK_pd Subfamily PTPRK 329-568 4.4e-80 263.8 In-house 36-275 (314) alignment
Range on Protein: 329-568
Range on HMM: 36-275/314.0
KSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSD
 .|    | .|||. .||.|.|.|| |.   |.  ||||||..||. .| .|.|.|| |.. | .||||.......| |||||   | |..|| .||| |
daakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed

GSRlYDKILVELTEELTYSDYVLRQFSLTH--TEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQsGNTCITVHCSGGVGRTGVFCAVSIL
..  |..| ||| |  . ...| | |....     .  |.||||| . ||| . | |  ||..|. .|.|.|.. ..  | |||| | ||||.|.|..|.
tev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidiv

IERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQE
.. .. ||..|||..|. || ... ||.|..|| |.|  | |
ldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile

0037934 (Phosphotyrosine protein) phosphatases II 329-570 9.2e-77 253.1 In-house 3-242 (243) alignment
Range on Protein: 329-570
Range on HMM: 3-242/243.0
KSAMLSCNAAKNRYANILPYERTRVALhmrPGevgSDYINASFIDGNHRlkaYIATQAPVPRTFED----FWRMLWEQESAVIVMLTREEEAGKLKCHRY
. |.| .|  |||| .||||...|| |   .|   ||||||..|..  |   .||||.| | |.||    |||||||. . ||||||...| |..||..|
siallpenlsknrysdilpydhsrvkl...eg...sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPsdGSRLYDKILVELTEELTYSDYVLRQFSLTHTE-EKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQ-------SGNTCITVHCSGGVGR
||  |.  |... |.|..| ...||..| ..|.... .. .| |...... ||| | |.|   |.|.. .| .....       ...  . ||||.||||
wp..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

TGVFCAVSILIERVkaeGlIDVFQTVQHLRLQRPA-MVQTKDQYEFCYTTIQEYL
||...|  ......   | .|....|..|| |||  .||| .||.|.|  ..|.|
tGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallell

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 329-571 1.8e-70 232.2 In-house 21-269 (274) alignment
Range on Protein: 329-571
Range on HMM: 21-269/274.0
KSAMLSCNAAKNRYANILPYERTRVALHMRPGEVG-SDYINASFIDGNH-RLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWP
.  ... .. |||| .||| |..|| |. . .|   |.|||| .| | . . |||.||| |.| | .|||||....|. ||||||. .|| . ||..|.|
eeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfP

SDGS----RLYDKILVELTEELTYSDYVLRQFSLTHTEEksSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSGNT--CITVHCSGGVGRTGVF
 . .      |... .. .. ..  || .|...| ..|.  .| |  .  |||||   |..   |.||. .||. .... .    . |||| |.||||.|
daedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcf

CAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLE
 |.|| . ....|. .||...| .|||.|  ||||..|||. . .. .||.
iaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk

0049772 (Phosphotyrosine protein) phosphatases II 329-572 3.2e-43 144.0 In-house 39-282 (314) alignment
Range on Protein: 329-572
Range on HMM: 39-282/314.0
KSAMLSCNAAKNRYANILPYErTRVALHMRPGEvGSDYINASFIDGNhrlKAYIATQAPVPRTFEDF----------WRML--WEQESAVIVM-------
. | | .|  |||| .|||.. .|| |.  |.. ||||||||..||    ...||||.| . |..||          |||   ... . .|||       
lvadlflnrdknryldilpad.nrvilpglpvs.gsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevla

--------------LTREEEAGklkcHRYWPSDGSRLYdkilvelteeltysdY-------VlrqfslthteeksSRIVRQFQCTDWPDSGLPeSGVGLI
              |..  . |      ....|   |                        .             .| . .. ....|| . | .   . 
delsrLdaAlgKtpllildgng....neptaadlellk...............eelydpelf.............erlgikylripvpDgsap.lledfd

DLIGQVEKWqqqSGNTCITVHCSGGVGRTGVFCAVSILIERVkaeGLiDVFQTVQHLRLQRP-----AMVQTKDQYEFCYTTIQEYLES
...  .|..   . .... |||..|.||||.|... .|. .    |. .. ......||.||      .... .||||..  ..|||. 
eflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkf

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 330-375 8.3e-08 26.0 In-house 41-86 (440) alignment
Range on Protein: 330-375
Range on HMM: 41-86/440.0
SAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGN
 | |  |  |||| ||| |...|| |.   |   |||||||.|.| 
iaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 331-569 4.4e-34 112.4 In-house 49-282 (290) alignment
Range on Protein: 331-569
Range on HMM: 49-282/290.0
AMLSCNA--AKNRYANILPYERTRVALHmrPGEVGsDYINASFIDGNHrlKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSD
 ..  |.   |||| ..   ..||| |.   |  | ||. | ...| .    .| || ..  |  |.|||. ... |.||||    | || ||..|.|  
kifdkntefkknrykdvvcndktrvilk..dGydG.dyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypek

-GSRL-YDKILVELTEELTYSD-YVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKwqqQSGntCITVHCSGGVGRTGVFCAVSI
 |  | . .| |  .|| .  .  ... .|. . ..  . ... ..   |||  .. | . |. ..  . |    ||   ..|||| |.|||| | |. .
eGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk...asG..pvvvhcsaGiGrtGtfvaiev

LIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEY
 .. .     .|. ..|. ||  | . ||   ||      . ..
glqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 331-416 2e-10 33.8 In-house 22-80 (169) alignment
Range on Protein: 331-416
Range on HMM: 22-80/169.0
AMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINAsfidgnhrlkayiatqapvprtfedfwRMLWEQESAVIVMLTREEEA
| |.|| .||| |  |   .||| |.    ..|||||||                           ||.|| ...|||.|   .. 
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddk

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 331-416 2.4e-10 33.5 In-house 21-79 (169) alignment
Range on Protein: 331-416
Range on HMM: 21-79/169.0
AMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINAsfidgnhrlkayiatqapvprtfedfwRMLWEQESAVIVMLTREEEA
| |.|| .||| |  |   .||| |.    ..|||||||                           ||.|| ...|||.|   .. 
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddk

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 333-570 4.8e-32 106.0 In-house 32-270 (285) alignment
Range on Protein: 333-570
Range on HMM: 32-270/285.0
LSCNAAKNRYANILPYERTRVALHMRpgevGSDYINASFIDGNH-RLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSDGSR
  .|   ||||..   | ||| |. .      ||| ||..        .||.|| |.| |. |||.|..... | ..||    | |  ||  |.|     
yeanpdlnryadvrcieetrvvlknh....drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

L-----YDKILVELTEElTYSDYVLRQFSLTHTEEKSSRI--VRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQsgNTCITVHCSGGVGRTGVFCAVS
.     |.  | |  || . .  .|  .... ||. ||    . . |   |||   ||    .|.|   |.| . .  .. | |||| |||||  |  . 
vvkfgkyeitlteckee.aiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk..ekpicvhcsagvgrtatfvgid

ILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
    |.  .  |.... |. .|  |   ||.. |. | |  . ||.
yatirimenpniemldivremramrfqavqshmqflflyvvlmeyf

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 333-573 7.7e-31 101.9 In-house 45-290 (305) alignment
Range on Protein: 333-573
Range on HMM: 45-290/305.0
LSCNAAKNRYANILPYERTRVALHmrpGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSDGSRL
 . .| |||| ..   .. || |.   |    .|| | ..      | .| ||||. .|  ||| | ...    | ||    | |  ||. |..|.    
eaqeagknrykdvgcldnnrvkle...gpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdv

------YDKILVELTEELTYSDYVLRQFSLTHT------EEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVekwQQQSGntCITVHCSGGVGRTGVF
       .|| | .    |..     .  .|.|        ...| | ..   |||| |.| . . ...|. .    .   |   |.|||| |.||||  
lefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka...rpskg..pivvhcsagigrtgsv

CAVSILIERVKAEGLIDVF-QTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLESF
  .  ..... |   |.   . .|..| ||   .|| .|| | .  | .|..  
vmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkk

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 333-385 2.8e-12 40.6 In-house 45-94 (95) alignment
Range on Protein: 333-385
Range on HMM: 45-94/95.0
LSCNAAKNRYANILPYERTRVALHMRpgeVGSDYINASFIDGNHRLKAYIATQ
  .|  |||. ||.||. |||.|  .     |||||| |.||  | ..|||.|
seanipknrflnifpydatrvvlttk...rdsdyinacfvdgyarkncyiaaq

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 334-574 5.1e-74 244.1 In-house 49-288 (297) alignment
Range on Protein: 334-574
Range on HMM: 49-288/297.0
SCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRlkAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKlKCHRYWPSDGSRLY
  |  |.||.|||||.. || |...  .  |||.||||. ||.    .|.|| | . | .|||.|..... ..||||. ..|  | || |||. .|.  .
kvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttf

DKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPE--SGVGLIDLIGQVEKWQQQSGNTCITVHCSGGVGRTGVFCAVSILIERVK
 .. |.|.     . .. |....|. . |. |.|.|.| ..|||   ..  |   |..|| .|.|  .|  .. . |||. |||||||....   . ..|
GdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeak

AEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLESFD
 |  .|.|..|..|| .|| .||||.||.| | .. |.| | |
rekevdifglvkklrqerpylvqtkeqykfvyvavleallsed

subfamily_CG7180_pd Subfamily CG7180 334-570 1.2e-64 212.8 In-house 40-290 (296) alignment
Range on Protein: 334-570
Range on HMM: 40-290/296.0
SCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKlKCHRYWPSDGSRLY
. |  |||. ...||. .|| |.   ||  ||||||...|.  . |.|| |.||. .| ..|||.....|.  .|.||.. .  | ... ||| ..   |
kenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqy

DKILVELTEELTYSDYVLRQFSLTHT----------EEKSSRIVRQFQCTDWPD-SGLPESGVGLIDLIGQVEKWQQQS----GNTCITVHCSGGVGRTG
 .|.||..|| .|.. . |.| ||..          ..   |||..|| | |.    .| |  .||.|. .|..|...      .  . |..| |..|.|
geifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsG

VFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
|..|. . .| |. |. .|||. |. || .|| .|.....| ..| ...|..
vylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 334-566 7.2e-55 180.7 In-house 6-237 (239) alignment
Range on Protein: 334-566
Range on HMM: 6-237/239.0
SCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFI-DGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSDGSRl
  | ||||||||. |...|| |     .  |||||||.. | .   |||||||  |  .  |||||.|..  .||||||   |  | |||.|||   |. 
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk.

YDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKwQQQSGNTCITVHCSGGVGRTGVFCAVSILIERVKA
| .. | | .   ..||..| | ...  .   | | |.. | ||| |.|.    .. |  .. | .   |     .||| |||||| |  .  .. . | 
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakk

EGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTI
.  .|.|. |. .| .|| |||| .|| | . ..
qktvdifnyvkairedrphmvqtseqyvfihlav

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 334-566 5.5e-36 118.7 In-house 35-265 (281) alignment
Range on Protein: 334-566
Range on HMM: 35-265/281.0
SCNAAKNRYANILPYERTRVALHM-RPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSDG--S
  |  ||||.||   . .|| |..  | .  .||| | .|      . || || |   |  |||||.|..... |||| .  |. . ||  |.| .    
pvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcc

RLYDKILVELTEELTYSDYVLRQFSLTHteEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVekwQQQSgnTCITVHCSGGVGRTGVFCAVSILIERV
  .||. |.  .       |  .. |..  |  .|.. ..   .|||  .|||   .. .. ..   . .|  |   .||| ||||.| . || | .. .
lqfdklsvsyedstvnkslvttrlnlsy..egetrlithwlwkewpdwqvpessevmlkilrki...rars..tppvihcsagvgrsgtlmaveialqsi

KAE-GLIDVFQTVQHLRLQ-RPAMVQTKDQYEFCYTTI
..   | |. | | |||.  | | ||| .|| . .  .
hshftlpdikqivshlrvtgraasvqtlqqymliwkvl

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 334-570 1e-30 101.4 In-house 53-289 (305) alignment
Range on Protein: 334-570
Range on HMM: 53-289/305.0
SCNAAKNRYANILPYERTRVALHmRPGevGSDYINASFIDGNH-RLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSD-GSR
  . .||||...   ... | |. .|    |||| | ..       | .|..| |. .| ..|| |. ..    |||| .  | ||||| .|||   | .
diaitknryqdvpcqdqsavkld.kps..psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgek

--LYDKILVELTEELTY----SDYVLRQFSLTHTEEKsSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVekwqqQSGNTCITVHCSGGVGRTGVFCAVSI
  |   |.||           ..  .  . ||.. .. .  ||..| |.||| |.|   .  ..|.  .     .  .  | |||| |.||||   |.  
lelksgivvenvsgskpmerdaeiqitllnltysgdq.kmsvrhlqwtewpdrgvppckltslellsai.....rgskvpivvhcsagigrtgtivaiey

LIERVKAEG-LIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
..|..  .     . . |. || ||   .|.  || | .  . .|.
ilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 335-577 4.2e-88 289.8 In-house 8-249 (250) alignment
Range on Protein: 335-577
Range on HMM: 8-249/250.0
CNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLkCHRYWPSDGSRLYD
 |  |||||.|.... .|| |.   |.  ||||||||..| .  ||.||||.|...|.||||||..|..|..|||||  .| .|  .|.||| .... | 
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyG

KILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSGNTCITVHCSGGVGRTGVFCAVSILIERVKAEG
...|.| .. ...||. |.. |........|||||.. . ||| | ||     ..|. .|.. |||.||. . |.|| ||||.| |.|.. ..||.| | 
dvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkek

LIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLESFDLYA
 .|||. .. || .|| .|....|| |.|. |...|.|.. ||
vvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedya

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 335-566 7.3e-55 180.7 In-house 6-236 (239) alignment
Range on Protein: 335-566
Range on HMM: 6-236/239.0
CNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFI-DGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSDGSRlY
 | ||||||||. |...|| |     .  |||||||.. | .   |||||||  |  .  |||||.|..  .||||||   |  | |||.|||   |. |
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk.y

DKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKwQQQSGNTCITVHCSGGVGRTGVFCAVSILIERVKAE
 .. | | .   ..||..| | ...  .   | | |.. | ||| |.|.    .. |  .. | .   |     .||| |||||| |  .  .. . | .
cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakkq

GLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTI
  .|.|. |. .| .|| |||| .|| | . ..
ktvdifnyvkairedrphmvqtseqyvfihlav

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 335-570 2.1e-51 169.8 In-house 47-279 (439) alignment
Range on Protein: 335-570
Range on HMM: 47-279/439.0
CNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKlkchrYWPSDGSRLYD
 . .|||| .. ... |||.|.  ||   | |||| .|.| .  | |||||.|   | .||||...|. .. |||||   |. |     |||||.   | 
ydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcyg

KILVELTEELTYSDYVLRQFSLTHTEE--KSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSGNTCITVHCSGGVGRTGVFCAVSILIERVKA
 | |    ..   .||.| | .    .  .  | | ||. . |||  .|     ..|..  ..  ...     . |||| ||||||   |. | .|..|.
diavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlkl

EGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
|  .|.   |. || ||  |||.  || | | .. | .
enkvdikgivkvlrkqrkqmvqalcqyvfiynavledi

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 335-570 2.8e-28 93.8 In-house 42-271 (288) alignment
Range on Protein: 335-570
Range on HMM: 42-271/288.0
CNAAKNRYANILPYERTRVALHmrpgEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSD-GSRL-
 |....|| |.   . ||| |.    .    ||.|  .  ..  .  | .|||.  | | .|.|| |..   ||||..  | || |   |.||  | .  
anptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

YDKILVELTEELTYSDYVLRQFSLTHTEE-KSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVekwqqQSGNTCITVHCSGGVGRTGVFCAVSILIERVK
. ..     .. .  | ...   |  ..| . . ||..    .|.| |.||. .  . |.  .     .| .  | ||.| |||||| .  . | .| ..
igrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililialeslr

AEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
 .  . . . ...|| .|   .||. || . .  . |.|
lddflgirsllaklreerfkaiqtemqylyvhrcvleel

Y_phosphatase Protein-tyrosine phosphatase 336-568 1.1e-83 275.6 Pfam-A 1-235 (235) alignment
Range on Protein: 336-568
Range on HMM: 1-235/235.0
NAAKNRYANILPYERTRVALHMRPGEvgSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWP--SDGSRLY
|  |||| .||||..||| |. ..|.  ||||||....| .. |..||||.|.. |.||||||.|.... ||||||..|| |. ||..|||  ...|  |
nkkknRykdilpydktrvklkgsegp..sdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

DKILVELT-EEL-TYSDYVLRQFSLTHTEEKS-SRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQqQSGNTCITVHCSGGVGRTGVFCAVSILIERV
..| |||. .|    ..|.||...|....|.| .|.|.|...|.|||.|.|||  .|.||| .|||.. .. .. ..|||| ||||||.|.|..||.|..
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

KAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQE
.||. .||.|.|..|| ||| |||. .||.|.| .|.|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 336-568 1.1e-83 275.6 In-house 1-235 (235) alignment
Range on Protein: 336-568
Range on HMM: 1-235/235.0
NAAKNRYANILPYERTRVALHMRPGEvgSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWP--SDGSRLY
|  |||| .||||..||| |. ..|.  ||||||....| .. |..||||.|.. |.||||||.|.... ||||||..|| |. ||..|||  ...|  |
nkkknRykdilpydktrvklkgsegp..sdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

DKILVELT-EEL-TYSDYVLRQFSLTHTEEKS-SRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQqQSGNTCITVHCSGGVGRTGVFCAVSILIERV
..| |||. .|    ..|.||...|....|.| .|.|.|...|.|||.|.|||  .|.||| .|||.. .. .. ..|||| ||||||.|.|..||.|..
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

KAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQE
.||. .||.|.|..|| ||| |||. .||.|.| .|.|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 336-568 2.8e-55 182.1 In-house 3-237 (237) alignment
Range on Protein: 336-568
Range on HMM: 3-237/237.0
NAAKNRYANILPYERTRVALHMRPGEvgSDYINASFIDGN-HRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPS-DGSRLY
| .||||.||  |. .|| |.   ..  ||||||....|     | |||.| |.  . .|||.|.|..  .||||||   |  .||||.|||| |  . |
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

DKILVELTEELTYSDYVLRQFSLTH-TEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQ-SGNTCITVHCSGGVGRTGVFCAVSILIERVK
 .. | |. .  .||| .| . |.. .. |  |.. |.| | ||| |.|.    |. .  .. .  .  |  .   .||| ||||||.|  .  .. . |
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

AEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQE
 . ..|... |. .  .|| ..|||||| | . || |
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtile

0041856 (Phosphotyrosine protein) phosphatases II 336-571 1.5e-50 166.6 In-house 1-172 (182) alignment
Range on Protein: 336-571
Range on HMM: 1-172/182.0
NAAKNRYANILPYERTRvalhmrpgevGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTreeeagklkCHRYWPsdgsrlydk
|  |||| .||||...|          ..|||||....|... . .||||.| ..|..||.|||.|.   .||.||         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

ilvelteeltysdyvlrqfslthteEKSSRIVRQFQCTDWPDSGLPEsGVGLIDLIGQVEKwqqqsGNTCITVHCSGGVGRTGVFCAVSILIERvkaeGl
                         |.  | . |.... ||| | |.    |.|.| .|..      . .. ||||.||||||...|  .....    | 
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.

IDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLE
......|...| .|| ||.| .|| |..  . |.|.
vsleeavklvrsrRpgmvitpnqyfflqlallelll

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 336-562 6.2e-26 85.7 In-house 52-282 (310) alignment
Range on Protein: 336-562
Range on HMM: 52-282/310.0
NAAKNRYANILPYERTRVALHMRPGEVgSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSDGS-RLYD
.  ||||....  . .|| |..       ||| | ..  |.  ...| .| |.  |  |||||.... .  |..| .  | |. ||  |||| |    | 
ymhknrysdvvcldtsrvklkidksry.edyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetyg

KILVE----LTEELTYSDYVLRQFS-LTHTEEKSSR----IVRQFQCTDWPDSGLPESGVGLidlIGQVEKWQQQSGnTCItVHCSGGVGRTGVFCAVSI
 | |      .||.   .  .         .|. .      |   .  .||| |.|.  .     . |    | . |  |. |||| |..|..| .|. .
cirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekcht...vpqrllaqvrhg.pcv.vhcsagkdrlyvvvalkl

LIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFC
 |....    .|. . . .|. .|   .||. || . 
kidkldrglkvdaeevktellksraiciqtelqylii

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 336-416 1.6e-08 28.4 In-house 34-113 (332) alignment
Range on Protein: 336-416
Range on HMM: 34-113/332.0
NAAKNRYANILPYERTRVALHmrPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFE-DFWRMLWEQESAVIVMLTREEEA
|   ||   .  ....|| |   | .   |. |||..||  .  ||| .|||.    |  ||||. |.. ..|...   .| 
nmdmnriphlycfdhsrvela..pqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidek

subfamily_CG42327_pd Subfamily CG42327 337-495 6.2e-29 95.7 In-house 29-191 (319) alignment
Range on Protein: 337-495
Range on HMM: 29-191/319.0
AAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRL-KAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPS----DGSR
  |.|..|..|   ||| |.  . .  . |..||.. | .     |||.|..   .  ||||..||| | ||| ||   | |  .| .|.|.    |. .
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnts

LYDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCtDWPDSGLPESGVGLIDLIGQVE
|| .||| | .  .   |..  . | . ... || .  .   .|.....| .   || .. .|.
lyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevr

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 337-442 7.1e-27 89.0 In-house 48-164 (350) alignment
Range on Protein: 337-442
Range on HMM: 48-164/350.0
AAKNRYANILPYERTRVALH--------MRPGEVGSDYINASFIDGN----HRLK--AYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCH
 ||||| ||||||..|| |.        ..    ..|||||...  .    .      |||||||.|.|..||.... . .  ||..|| . | .  ||.
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

RYWPSDGsrlYDKILVELTE
|||.  .   ||.| | |..
rYWqegs...ydditvklas

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 337-447 5.5e-17 56.1 In-house 49-172 (349) alignment
Range on Protein: 337-447
Range on HMM: 49-172/349.0
AAKNRYANILPYERTRVALHMRP--G------------EVGSDYINASFIDGNH--RLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLK
 ||||| .||||| .|| |.  .                .  ||||| ..   .    | |||||||.| | .||....  ..  ... |. ..| .  |
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

CHRYWPSdGSrlYDKILVELTEELTYS
|..||   .|  |. | | | .   |.
cdiywqe.ls..ysnitvklqnsslyi

subfamily_eak_pd Subfamily eak 337-481 2.8e-12 40.7 In-house 53-195 (332) alignment
Range on Protein: 337-481
Range on HMM: 53-195/332.0
AAKNrYANILPYERTRVALHMRPgEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSDG--SRLYD
  .|   .|.||.|  | |          ||||| .. ..  . || | ..       ||.|. || |  ||.|  . | .  |  .|.| ..     . 
vnrn.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfG

KILVELTEELTYSDYVLRQFSLTHTEEKssRIVRQFQCTDWPDSGLP
.. ||  | .  . .  |.. |.  .|     |  ..   | .  ||
ildverkefvkrniletrllelskGnet..hrvlhykvfGwtettlp

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 339-559 1.1e-30 101.4 In-house 53-270 (301) alignment
Range on Protein: 339-559
Range on HMM: 53-270/301.0
KNRYANIlPYE-RTRVALhMRPGEVGsdYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSDGSRLYD---
|.|| .. | .  | | . .  |.     | | .|. . . . .||||.|.. | |||| ||   .   ||||... |  . ||. | |.. |.  |   
khryptv.PckPstavev.ivdGkrv..PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr

-KILVELTEELTYSDYVLRQFSLTHTEEK-SSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKwqqqsGNTCITVHCSGGVGRTGVFCAVSILIERVKA
 || .. .| .   . . |.. .. . .| ..| |  .| ..|.| |.|.| . | ||.  | |      .  | |||| |.||.  | .  .|  .|.|
fkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk.....sekPivvhcsaGiGrsvafigteylarevea

EGLIDVFQTVQHLRLQRPAMVQTKDQY
.  |.. ....||| .|   |||. | 
dptieltealkhlrehrwngvqtnsql

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 339-577 5.9e-20 66.2 In-house 46-283 (312) alignment
Range on Protein: 339-577
Range on HMM: 46-283/312.0
KNRYANILPYERTRVALHmrpGEvGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPS-------DGSR
 ||| ||  ..| | .|    |.    || | |.    . . ...||.|.  |   ||..     |. |..|.   | |  || .|          .  |
lnrypniqcwdrgrftla...gd.enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhr

LYDKILVELTEELTYSDYVLRQ-FSL-THTEEKSSRiVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQqsgntCITVHCSGGVGRTGVFCAVSILIER
.| .   |.       | .  . . .  ..  . |. . ..| . ||| |.|.|      |.  | | ..      .  ||| |||||| .. .  .|  
vyteycteieiggkskdkithrvlkvvvkatgqesk.lnhyqwaswpdhgmpdscdtalrllsavkkdkk.....pviahcsagvgrtgtlaliesmiaa

VKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLESFDLYA
..     .| ..   || .|   |..  || ..  .. |.| |  || 
lrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglyk

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 346-479 8.5e-12 39.5 In-house 3-125 (130) alignment
Range on Protein: 346-479
Range on HMM: 3-125/130.0
LPYERTRVAlhmrpgevGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAgklkcHRYWPSDGS-RLY-DKILVELTEE
|..| .|.         | .||||||.    | . |. ||.|.  |  |||.|. |.   |.|.|   ||        |||       | ..|.| ||. 
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdr

LTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSG
  .      ..   .   .| . .  || ..||  |
defknikasnleiesdlneshqaltmfqisnwpsdg

0044763 (Phosphotyrosine protein) phosphatases II 347-569 1.1e-38 128.0 In-house 1-170 (178) alignment
Range on Protein: 347-569
Range on HMM: 1-170/178.0
PYERTRVALHMRPGEVGSDYINASFIDGNhrlkAYIATQAPvprtfEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSDGSrlydkilvelteelty
|..|||| |....|. .|||||||.|...     |.... |     .|....|.|.   .||.|| | | |.|||..|||.. .                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

sdyvlrqfslthteekssrivRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSGnTCITVHCSGGVGRTGVFCAVSILIERvkaeGLiDVFQTVQHLR
                      |.... .||.| |..   . ...  .|......|  .. |||| ||||.|...|  .....    || .... ....|
.....................iqylhipipDhgvpdllehflefvefieealdekg.gpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvr

LQRPaMVQTKDQYEFCYTTIQEY
 .|| .|.. .|....|   ...
erRp.ivpnpgqlrqLyefelrl

0046846 (Phosphotyrosine protein) phosphatases II 356-572 3.4e-45 149.2 In-house 4-175 (176) alignment
Range on Protein: 356-572
Range on HMM: 4-175/176.0
HMRPGEVGSDYINASFIDGNHrlkaYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSDGSRLYdkilvelteeltysdyvlrqfs
...  . ..|||||..|.|..    .||||.|.|||..||..||.|.   ..|.|| | | |.|||..|||   .  .                      
rllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi......................

lthteekssrivrQFQCTDWPDSGLPESgVGLIDLIGQVEKWQQQSgnTCITVHCSGGVGRTGVFCAVSilieRVKAEGLIDVFQTVQHLRLQRP-AMVQ
             |.....||| | |..   |..|. ........    .. ||||.|.||||...|       .. |  ..|.......| |||  .||
.............qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavq

TKDQYEFCYTTIQEYLES
| .||.|.|  ....|..
tpeQyrflyefellllkk

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 359-479 1.3e-13 45.2 In-house 117-234 (244) alignment
Range on Protein: 359-479
Range on HMM: 117-234/244.0
PGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAgklkcHRYWP-SDGSRLYD-KILVELTEELTYSDYVLRQFSL
 | .|  ||||||.    |   || || |.  |  |||.|. |.   |.|.|   ||        ||| |.    |.  | | ||.   . .    .. .
kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdseplewyeeditvtltdrdefknikasnlei

THTEEKSSRIVRQFQCTDWPDSG
    ..| . .  || ..||  |
esdmneshqaltmfqisnwpsdg

0036282 (Phosphotyrosine protein) phosphatases II 363-563 3.5e-51 168.7 In-house 1-163 (174) alignment
Range on Protein: 363-563
Range on HMM: 1-163/174.0
GSDYINASFIDGNHRLKAYIATQAPVPrtfedFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSdgsrlydkilvelteeltysdyvlrqfslthTEEK
||||||||..|...... .||.|.| .     ||.||.|. . ..|||..|.| |. ||..|||.                               . | 
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lred

SSRIVRQFQCTDWPDSGLPESGVgLIDLIGQVEKWQQQSGNTCITVHCSGGVGRTGVFCAVSILIERVKaEGLIDVFQTVQHLRLQRPAMVQTKDQYEFC
 .| . |.... ||| | |.. . |.... .||........ .. ||||.||||||...|  ... . . |.|.|....|. |||||| |||| .||.|.
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

Y
|
y

0043147 (Phosphotyrosine protein) phosphatases II 363-563 7.7e-46 151.3 In-house 4-154 (172) alignment
Range on Protein: 363-563
Range on HMM: 4-154/172.0
GSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREeeagklkchrywpsdgsrlydkilvelteeltysdyvlrqfslTHTEEK
||||||||..|...  . .||||.| ..|..||||||.|.   .||.||..                                           ... |.
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpel

SSRIVRQFQCTDWPDSGLPeSGVGLIDLIGQVEKWQQQSGNTCITVHCSGGVGRTGVFCAVSILIervkaEGLiDVFQTVQHLRLQRPAMVQTKDQYEFC
 .| . |.... ||| | | .   |.... ........| . .. ||||.||||||...|  ...     .|| .....|...| .|| .||...|| |.
lerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl.sleeavalvrekRpgavqnpsqyrfl

Y
|
y

0051429 (Phosphotyrosine protein) phosphatases II 364-572 5.9e-53 175.5 In-house 4-227 (272) alignment
Range on Protein: 364-572
Range on HMM: 4-227/272.0
SDYINASFIDGNHR---LKAYIATQAPVPRTFEDFWRMlWEQESAVIVMLTREEEAGKLKCHRYWP------------SDGSRLYDKILVELTEELTYSD
|.||||....|..|    ........| | | .||||. .|.   .||.|..||| |.|||.||||            |. . || .. | |..| ...|
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

YVLRQFSLTHT-EEKSSRIVRQFQCTDWPDSGLPESGvgLIDLIGQVEKwqqqsgNTCITVHCSGGVGRTGVFCAVSILIERVKAEGLID--------VF
|.|| . ||..   . .| |.....||||| | |..   |..|. .. .      .  . ||||.|..|||...|. .|...| .|  .|        ..
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

QTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLES
..|..|| |||..||| .||.|.|  ..|.|.|
eaveelraqrpgavqteeqylflyeallellrs

0051082 (Phosphotyrosine protein) phosphatases II 364-566 3.9e-37 122.5 In-house 3-149 (151) alignment
Range on Protein: 364-566
Range on HMM: 3-149/151.0
SDYINASFIDGNhrlkaYIATQAPVPrtfeDFWRMLWEQESAVIVMLTREEEAGklKCHRYWPSDGsrlydkilvelteeltysdyvlrqfslthteeks
|||||.|...|.     ......| .    ||...|.|.   .||.|. ||| |  .|..|.|. |                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

sRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKwqqqSGNTCITVHCSGGVGRTGVFCAVSILIERvkaeglIDVFQTVQHLRLQRPAMVQTKDQYEFCY
 . |......|||| |||.|   ..... ....     .| .. ||||.|.||||...|. .....      ..........||.|| .||...|. |..
.ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

TTI
  .
fal

0049260 (Phosphotyrosine protein) phosphatases II 371-563 6.4e-41 134.9 In-house 1-143 (152) alignment
Range on Protein: 371-563
Range on HMM: 1-143/152.0
FIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWpsdgsrlydkilvelteeltysdyvlrqfslthteekssrivrQF
|||| .. ...||||.| | |..||||||.|.   .|||||...| |||||..|.                                           |.
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

QCTDWPDSGLPESGVGLIDLIGQVEKWqQQSGNTCITVHCSGGVGRTGVFCAVSILIervkaeGLIDVFQTVQHLRLQRPAMVQTKDQYEFCY
... |||.| |..   |..|.  .||. ... . .. ||||.||||||...|  ...        ......|...| .|| .|....|..|.|
lhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 373-562 1.3e-14 48.4 In-house 84-280 (302) alignment
Range on Protein: 373-562
Range on HMM: 84-280/302.0
DGNHRLKAYI-ATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSDGS-----RLYDKILVELTEELT-Y---SDYVLRQ--FSLTHTE
||  ...        |   | | .| .. . . |..| |.   | .. ||  |.  .       . |    |.. ..|  .    ...| .  .  ....
dGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkk

EKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQqqsgnTCITVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYE
.|  . |  .. . ||| | |.     .|..   | ..     . . |||| |||||| . |.   |.  . .   |. . |. .|  |   ||...|  
kkvkktvdilafsawpdhGapkeaytaldilkfcesyk.....knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqli

FC
. 
yl

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 375-428 2.3e-06 21.2 In-house 232-282 (440) alignment
Range on Protein: 375-428
Range on HMM: 232-282/440.0
NHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAgklKCHRYWPSD
  . .|.|||| |.  |  ||||.. . . . |.|| . ..     |  ||| .
yskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvn

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 379-564 3.8e-24 80.0 In-house 5-198 (199) alignment
Range on Protein: 379-564
Range on HMM: 5-198/199.0
KAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSD--GSRLYDKILVELTEELTYSDYVLRQFSLTH--TEEKSSRIVRQFQCTD
. ||||| |.  |. |||.|.||  |  |||.  ..   .     |||.   |.  |  . |      | .||..  . ||   |   |.| . ..| | 
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDSGLPESG--VGLIDLIGQVEKWQQQSGNTCITVHCSGGVGRTGVFCAVSILIERVK--AEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYT
| .   |.    ||..    .| |  .|  .. . |||| | | |||| |. | .   .     ..|.|.  . ||  |  .. . ..|.| | 
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 379-564 4.1e-24 79.8 In-house 4-197 (198) alignment
Range on Protein: 379-564
Range on HMM: 4-197/198.0
KAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSD--GSRLYDKILVELTEELTYSDYVLRQFSLTH--TEEKSSRIVRQFQCTD
. ||||| |.  |. |||.|.||  |  |||.  ..   .     |||.   |.  |  . |      | .||..  . ||   |   |.| . ..| | 
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDSGLPESG--VGLIDLIGQVEKWQQQSGNTCITVHCSGGVGRTGVFCAVSILIERVK--AEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYT
| .   |.    ||..    .| |  .|  .. . |||| | | |||| |. | .   .     ..|.|.  . ||  |  .. . ..|.| | 
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_hpo-7_pd Subfamily hpo-7 390-568 9.3e-14 45.9 In-house 45-225 (263) alignment
Range on Protein: 390-568
Range on HMM: 45-225/263.0
RTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPS--DGSRLYDKILVELTEELTysDYVLRQFSLTHT--EEKSSRIVRQFQCTDWPDSGLPESGV
.| . |....  ... |.|||.  .|.|. || .|.|   |. . . .. |  |.     | .|.   |. |  | |  . |.... . |..   ||   
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelar

GLIDLIgqveKWQQQSgnTCITVHCSGGVGRTGVFCAVSILIE------RVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQE
  . ..    |  ..|    . |||| |.||.  |  . ..        .    . .|  . ...|| .|.. ..|  |  |   .. .
eilnil....kvarns..kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLd

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 391-569 8.3e-17 56.1 In-house 40-220 (255) alignment
Range on Protein: 391-569
Range on HMM: 40-220/255.0
TFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPS--DGSRLYDKILVELTEelTYSDYVLRQFSLTHT--EEKSSRIVRQFQCTDWPDSGLPESGVG
| . |....  ... |.|||.  .|.|. ||..|.|   |. . . .. |  |.  . .| |||   .| |  | |  . |. .. . |..   ||    
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

LIDLIgqveKWQQQSgnTCITVHCSGGVGRTGVFCAVSILIE------RVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEY
.  ..    |  ..|    . |||| |.||.  |  . ..        .    . .|  . ...|| .|.. ..|  |  |.  .. ..
ilnil....kvvrds..ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldl

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 420-560 7.3e-07 23.0 In-house 149-292 (332) alignment
Range on Protein: 420-560
Range on HMM: 149-292/332.0
KCHRYWPSDGSRLyDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPD-SGLPESGVGLIDLIG-QVEKWQQQSGnTC---ITVHCSGGV
 |...||  .|.  |   . .     .|.  .. | || ||.|  .    ..  .| | | |||  . .   |  |  .  ...|  |   | . |. ||
icrkfwpekrskk.dfpalsiqasddhsethmktfnltvtekkqdhqtvlmhfyewadasklpeymldmrasiklqyirsskktg.vcigpimlvcatgv

GRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYE
 .  ..... |.. |.  |  . . .|.  ...||   ..|   | 
ekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpys

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 436-571 3.9e-22 73.2 In-house 64-195 (440) alignment
Range on Protein: 436-571
Range on HMM: 64-195/440.0
ILVELTEELTYSDYVLRQFslthTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSGNTCITVHCSGGVGRTGVFCAVSILIERVKAEGL
...|  . .  |||.   .     .   || ..|..   ||| |.|.    .. .| .|.. |...||  . |||| |.|||||  ||  ..  .|    
vmleevkgvpdsdyinasy....ingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdq

IDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLE
||.|  .. .| .|| |||| .|| | . .. | | 
idifsfinsmrnnrpqmvqtpeqyafvheavlegll

0048076 (Phosphotyrosine protein) phosphatases II 446-569 3.3e-25 83.8 In-house 26-142 (145) alignment
Range on Protein: 446-569
Range on HMM: 26-142/145.0
YSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSgnTCITVHCSGGVGRTGVFCAVSILIErvkaEGlIDVFQTVQHL
 .  . . ..||...|  .| . |.....||| | |..   |.... ..|.....    .. |||| ||||||...|  ....    .| ..........
kdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelv

RLQRPAMVQTKDQYEFCYTTIQEY
| ||| .|.. .|..|.|  ..|.
rsqrpgavpnpgqlrflyefelel

subfamily_Tensin_pd Subfamily Tensin 454-522 8.6e-06 18.4 In-house 56-123 (189) alignment
Range on Protein: 454-522
Range on HMM: 56-123/189.0
FSLTHTEEKSSRIVRQFQCTDWPDSGLPESGvGLIDLIGQVEKWQQQSGNTCITVHCSGGVGRTGVFCA
| |.. .   |.. .. .   |||   |     |  .. ....| ..  .  . ||| || ||.||  .
fnlsekrydisklnkkvldfGWPdllaPsle.klcsicksldsWlkadpqnvvvvhckGgkgrigvvvs

0048179 (Phosphotyrosine protein) phosphatases II 455-564 4.4e-23 77.0 In-house 35-139 (144) alignment
Range on Protein: 455-564
Range on HMM: 35-139/144.0
SLTHTEE--KSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQqsGNTCITVHCSGGVGRTGVFCAVSILIervkAEGlIDVFQTVQHLRLQRPAM
.||.. |     | . |.....||| | |..   |....  .|....   . .. ||||.||||||...|  ...     .| ..........| .|| .
nlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpga

VQTKDQYEFCYT
|.. .|..|.. 
vpnpgqlrfLle

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 463-570 1.6e-10 34.8 In-house 216-344 (349) alignment
Range on Protein: 463-570
Range on HMM: 216-344/349.0
SSRIVRQFQCTDWPDSGL---PESGVGLI----DLIG--QVEKWQQQSGNTCITVHCSGGVGRTGVFCAVSILIE----------RVK--AEGLIDVFQT
.  .. |.|  .|.|..|   | | .  .    |||     ... ...  . . |||| | |||||.. . .|..          ..|  |     .. .
kPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisii

VQHLRLQRPAMVQTKDQYEFCYTTIQEYL
| .|| || .|||   |. ..| .. .|.
vnelrkqrismvqnlaqfiaiyealLkyf

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 465-569 2e-15 51.4 In-house 215-343 (350) alignment
Range on Protein: 465-569
Range on HMM: 215-343/350.0
RIVRQFQCTDWPDSGL---PESGVGLID----LIGQ--VEKWQQQSGNTCITVHCSGGVGRTGVFCAVSILIE---------------RVKAEgLID-VF
 .| |.|   |.|..|   ||| .  ..    || .   |.. ...  . | |||| ||||||.....  |..                | |. . | ..
yvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaak.trDlis

QTVQHLRLQRPAMVQTKDQYEFCYTTIQEY
..|..|| ||  |||..||. |.| ... |
iivnelrkqrismvqnldqfifiYeallfy

PTPc_DSPc_SM00012 467-567 4.8e-34 112.1 In-house 2-104 (105) alignment
Range on Protein: 467-567
Range on HMM: 2-104/105.0
VRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSG-NTCITVHCSGGVGRTGVFCAVSILIERVKAE-GLIDVFQTVQHLRLQRPAMVQTKDQYEFCYT
|.....|.||| |.||..  ...|. .|.|....|. .. . |||| ||||||.|.|..||......| . .|.||.|..|| ||| ||||..|| |.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

TIQ
 ..
all

PTEN_1 468-560 1.1e-07 26.9 In-house 93-183 (196) alignment
Range on Protein: 468-560
Range on HMM: 93-183/196.0
RQFQ--CTDWPDSGLPeSGVGLIDLIGQVEKWQQQ-SGNTCITVHCSGGVGRTGVFCAvSILIERVKaeglIDVFQTVQHLRLQR-PAMVQTKDQYE
....    ...| | | |   |.| . ... | .. . . .. ||| .|.||.|. .| . |... |     .. ......| .| |.....  | .
sgveylhfpieDhgap.slselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva.ayLmykgk....ltadeAlelvrekRppgapnspsqer

0038934 (Phosphotyrosine protein) phosphatases II 473-571 1.5e-11 39.8 In-house 85-178 (194) alignment
Range on Protein: 473-571
Range on HMM: 85-178/194.0
TDWPDSGLPESGVGLIDLIGQVEKWQQQSGNTCITVHCSGGVGRTGVFCAVSIlIERvkaEGLiDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLE
  .|| | . |   | . .  |... ... . .. ||| .|.||||...|  . |.|    |. .. . ....|  || .... |..|  ..  .|. .
lpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYL.iyr...lgm.saeeAialfrekRpgaipnqdyleallkrykelrk

subfamily_PTEN_pd Subfamily PTEN 487-558 3e-07 25.6 In-house 98-168 (184) alignment
Range on Protein: 487-558
Range on HMM: 98-168/184.0
LIDLIGQVEKWQQQSGNTCITVHCSGGVGRTGVFCaVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQ
| ... ..||| ... .  . |||  | |||||   |. |... . |   .. .  .. | .    |.   |
leeivediekwleedkknvvvvHCkaGkGRtGvli.vayllkslllekaeealelfaeaRtknkkgvtiPsq

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 491-566 1.5e-15 51.9 In-house 215-291 (297) alignment
Range on Protein: 491-566
Range on HMM: 215-291/297.0
IGQVEKWQQQS-GNTCITVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTI
. |.|  . .   |. . |||| ||||.||     ....... . . ||   ...|| ||. .||| .|.|..|. .
flqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav

subfamily_PRL_pd Subfamily PRL 494-554 2.9e-06 21.4 In-house 81-135 (151) alignment
Range on Protein: 494-554
Range on HMM: 81-135/151.0
VEKWQQQSGNTCITVHCSGGVGRTGVFCAVSILIERVKAEglidvfQTVQHLRLQRPAMVQ
...  .........|||  |.||. |. |.... . .| |      ..|. .| .| . . 
lkekfkeepkstvavhcvaGlGraPvlvalalieaGmkye......davefirekrrgain

subfamily_PTPDC1_pd Subfamily PTPDC1 498-564 1.3e-08 29.5 In-house 111-170 (182) alignment
Range on Protein: 498-564
Range on HMM: 111-170/182.0
QQQSGntCITVHCSGGVGRTGVFCAVSIL-IERVKAEglidvfQTVQHLRLQRPAMVQTKDQYEFCYT
  | |   ..|||  | |||||  |. ..  .|..||      .... .| .||  .||..| |..  
alqeg..kvavhChaGlGrtGvliacylvyakrltae......kaiklvrskrpksiqtreqvelvke

subfamily_CG42327_pd Subfamily CG42327 499-570 6.2e-16 53.0 In-house 243-315 (319) alignment
Range on Protein: 499-570
Range on HMM: 243-315/319.0
QQSGNTCITVHCSGGVGRTGVFCAVSILIERVKAE-GLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
... .  ..|||| ||||||.  |  | |....     .|. |.|...| .|   |.||.|||| | ...|| 
tresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 507-570 3.4e-16 53.4 In-house 2-65 (69) alignment
Range on Protein: 507-570
Range on HMM: 2-65/69.0
TVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
 |||| | |||| | |. . . |.|.| |.|.|  ||..|  || ||  . .| | . .. | |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 508-570 2.8e-16 53.6 In-house 2-64 (69) alignment
Range on Protein: 508-570
Range on HMM: 2-64/69.0
VHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
|||| | |||| | |. . . |.|.| |.|.|  ||..|  || ||  ...| | . .. | |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal

subfamily_ptpA1_pd Subfamily ptpA1 537-568 9.2e-06 19.6 In-house 365-396 (418) alignment
Range on Protein: 537-568
Range on HMM: 365-396/418.0
DVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQE
..|  | .|| ||| |||  .|| ||| || .
nlfsivlklreqrpgmvqqleqylfcyktild