Gene NvecPTP-sf6-2 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily NvecPTP-sf6
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP066_AA protein Get Run
NvecP066_AA_4-281 phosphatase_domain Get Run
NvecP066_AA_293-576 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 1-329 3.9e-158 522.6 In-house 4-331 (564) alignment 
Range on Protein: 1-329
Range on HMM: 4-331/564.0
PIPVEAFAMHVRRMHMDGDIGFSEEYEMVQPNdETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPE
||||.... ||.......|. |.|||. .... ..|||... .|||| ||||||||||||||| |...||. .||||||..||||... |.||.||||.|
pipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlae

TFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTRNYGALRVTANETFHMSYYVLRTFLVsHMQEEEEPRQVRQYHYTSWPDHGVPAHPAPLLS
|..||||||||| |..|||||.|||.|. ||..|||..|| .|| | || .|. ....|..||| . ......| |.|||.|.||||||||| ....||.
tiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLd

MVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANKLASRIRELR
..|.|...|.|.|||..||||||||||||||..|.||.|. .|.|.|....|...|..|| |||||.||.|||.|..||. ||.|||....| .....|.
lirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLa

EVDPNIGTTYMDLEFERLTR-DERHPTQFK
||... ..|...|||.||.  .| .. .|.
eveedtemtgleleFqrLatakeieleefa
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1-315 2.6e-115 379.9 In-house 4-318 (319) alignment 
Range on Protein: 1-315
Range on HMM: 4-318/319.0
PIPVEAFAMHVRRMHMDGDIGFSEEYEMVQPNDETfTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPE
.|.|. .........  |. .. .|.....  ... |.... .. || |||| ||.|||..|| |..|.|| .||||||..||||..  .||| |.|| .
eievqeLkerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlen

TFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTRNYGALRVTANETFHMSYYVLRTFLVSHMQEEEEPRQVRQYHYTSWPDHGVPAHPAPLLS
|..||||||||..| |.||||.| |... |. .|||.    .|| | || .|  ... |. | . . . ..| | |.| ...||.||||.|| .   || 
tiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslld

MVRTVSSAN-PPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANKLASRIREL
... .  .   ...||..||||||||||||||.|| ||.|  .||..||| .|...| .||.|||...|| ||..||.||| .| ||.. ..|  |...|
llkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkql

REVDPNIGTTYMDLEF
.| ... | |... ||
aekvadtgetgleref
subfamily_PTPRB_pd Subfamily PTPRB 1-280 2.6e-111 366.4 In-house 6-285 (293) alignment 
Range on Protein: 1-280
Range on HMM: 6-285/293.0
PIPVEAFAMHVRRMHMDGDIGFSEEYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPE
|| .| |. ||..|. | |..||||||...  ... . . . ...|. |||| ||..|||||| |..|..  .|||||||||.|||    |||.||||||
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpe

TFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDR-GTRNYGALRVTANETFHMSYYVLRTFLVSHmqeEEEPRQVRQYHYTSWPDHGVPAHPAPLL
|.|||||||||. | |||||||| |.|. ||..|||.   . .|| ..|| ... ... .|.|......   |.| |.|||||.||||||||| ....||
tvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektktll

SMVRTVSSAN--PPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAV
..|||| .|     ...|..||||||||||||||.|| .||.  .| ..|.||.| ..|..|||.||||.||.|||..... .
dfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
0051299 (Phosphotyrosine protein) phosphatases II 1-280 5.4e-111 365.9 In-house 4-286 (288) alignment 
Range on Protein: 1-280
Range on HMM: 4-286/288.0
PIPVEAFAMHVRRMHMDGDIGFSEEYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPE
.|.|| .. .|......|  |. ||.|..... ...|....|.|.|. |||| .|..|||||| |..|.|| .||||||.||||||.. .||| |||||.
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn

TFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTRNYGALRVTANETFHMSYYVLRTFLVSHMQ---EEEEPRQVRQYHYTSWPDHGVPAHPAP
|..|||||||||.. .|||||.|.|.||.||.||||..|. .|| ..||  .. ....|..||. |....    ..|.|.|...|||.||||||| .| .
tvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspel

LLSMVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAV
||...| | .|.... ||..||||||||||||||.|| .|..  .||..||...|...|..|. ||||..||.|...||.|..
lldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_PTPRA_pd Subfamily PTPRA 1-307 1.1e-104 344.9 In-house 13-322 (330) alignment 
Range on Protein: 1-307
Range on HMM: 13-322/330.0
PIPVEAFAMHVRRMHMDGDIGFSEEYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPE
|.||| .   .|.   |    | ||.. .   .   |   . .  || |||. ||. ||.||| |...||| ||||||| .||||..   |||.|||. |
plpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkee

TFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTRNYGALRVTANETFHMSYYVLRTFLVS---HMQEEEEPRQVRQYHYTSWPDHGVPAHPAP
| .|||||.||| || |||||.|.|| . || ||||| |.  || .||. ...  .  | .| |||    ....|...|.|||.|.||||| |||..|  
tvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiG

LLSMVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANKLASRIR
.|.... | . |. .|||..||||||||||||||.||..|.|   |. .|||.||...|..|  ||||. ||.||. .| |  . | ||.|.  | ....
mlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlq

ELREVDPNIG
.| .  ... 
klynkitgtd
0043336 (Phosphotyrosine protein) phosphatases II 1-278 4e-101 333.4 In-house 1-275 (278) alignment 
Range on Protein: 1-278
Range on HMM: 1-275/278.0
PIPVEAFAMHVRRMHMDGDIGFSEEYEMVQPNDEtFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPE
||.|. .. .........  ....|.| .. ..  .|. ..|.|.|| |||| .|..|||||| |..|.|.| ||||||.|.||||.. .|||.||||||
pisvkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe

TFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPdRGTRNYGALRVTANETFHMSYYVLRTFLVSHMQEEEEpRQVRQYHYTSWPDHGVPAHPAPLLS
|..||||||||.|. .|||||.|.|.|| ||.|||| .|. .|| ..||  .. |...|..||. |..... |. |.|..|||..||||||| ....||.
tvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllld

MVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVE
....| .|...  ||..||||||||||||||.|. .|...  ||..|..  |...|..|  .|||.|||.|...|| |
flkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1-316 1.6e-90 298.2 In-house 5-315 (315) alignment 
Range on Protein: 1-316
Range on HMM: 5-315/315.0
PIPVEAFAMHVRRMHMDGDIGFSEEYEMVqPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPE
|||.. .  .| . .     || ..|| . |  . .  . . .  || |||| ||.|||.||| |  ||   .|||.|||.|||||.   .||.|||...
pipldqlityvaqkkastkngfkqdyesi.pggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnva

TFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRgTRNYGALRVTANETFHMSYYVLRTFlvsHMQEEEEPRQVRQYHYTSWPDHGVPAHPAPLLS
. .||||.|.|.  . |||||.| |. .||...||||.    || . ||  .  . . |  ||.    .  ... |.| |.||||||| |||..  ||. 
svkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtl...svvfgdnirevvqlhytswpdmgvpkytiplmn

MVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANKLASRIRELR
..|||   .  ..|...|||||||||||||||||..|..|  |  |||. |....|..|  |||.  || ||.|||.|...|| | .  .    |   | 
lirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydsll

EVDPNIGTTYMDLEFE
   |. |.| .. .||
apspdtgstllqeqfe
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1-317 3.1e-77 254.5 In-house 2-314 (315) alignment 
Range on Protein: 1-317
Range on HMM: 2-314/315.0
PIPVEAFAMHVRRMHMdgDIGFSEEYEMVqPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPE
||||  |   | . .      ||||.  . |. ...  . . .. |  |||| ||. .|..|| |  ..   .|||||| || ...   |.|||||||. 
pipvaqfpafvnknrh..talfseefhdl.pdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlka

TFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPD--RGTRNYGALRVTANETFHMSYYVLRTFlvsHMQEEEEPRQVRQYHYTSWPDHGVPAHPAPL
. |||||||...  . |||.|...|  . || |||||    . ..|...|.  ..   .  | | .    ... || |.| |...| |||.||. . . |
svddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl...vtrkseesrtvtqfqftewPdkGvdkqtssl

LSMVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANKLASRIRE
| ... | . | .   ...||||||||||| .|..|......... ..||| ||...|.||  .|||| .| ||.||. | .    | .   ... ....
lklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqd

LREVDPNIGTTYMDLEFER
|.      | . |  |||.
lhtsvdgsgrskmtkefet
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1-319 1.2e-73 243.0 In-house 1-315 (515) alignment 
Range on Protein: 1-319
Range on HMM: 1-315/515.0
PIPVEAFAMHVRRMHMDgdIGFSEEYEMVqPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPE
|.|.  |   | .        ||||.  . |  . .    .    |  |||| ||. || .|| |  ..   .|||.|| || ...   |.||||||.. 
plplaqfPafvnknrht..tlfseefhdl.pgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnka

TFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPD--RGTRNYGALRVTANETFHMSYYVLRTFlvsHMQEEEEPRQVRQYHYTSWPDHGVPAHPAPL
. |||||.|...  . |.|.|.|.|  . || .||||    . ..| ..|    .   .  . |..   ..  ... | | |.|.| |||.||| |   |
svddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkl...tvlkgddsrtvtqfhfteWPdkGvpkhtssl

LSMVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANKLASRIRE
| ... | . .   . |.|.|||||||||| .|..||.. .|..  ..||| ||...|.||  .|||. || ||..|. | .    | .   ...  ...
lklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqd

LREVDPNIGTTYMDLEFERLT
|       | . |  ||. | 
lhssgdgrgrskmtkefqtlk
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1-291 6.5e-72 237.2 In-house 9-295 (297) alignment 
Range on Protein: 1-291
Range on HMM: 9-295/297.0
PIPVEAFAMHVRRmHMDGDIgFSEEYEMVqPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRsgAFIASQGPLPE
|||.  ||  |..  .. |. ||||.  . |. ....   . .  |  |.||.||. || ||| |  ..   .|||.|| .. |..    .|..| | ..
piplsdfatlvqk.nrhtdv.fseeflcl.peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmka

TFDDFWRMVWEQGSAIIVMLTQLEERGRrKCDQYWPDRGTRNYGALRVTANETFHMSYYVLRTFLVSHMQEeEEPRQVRQYHYTSWPDHGVPA--HPAPL
| .|||.||...  ..||||....|| . || .||.|.|. ..| . |. . . . . .. |.. |.. .     | |.||....|||. |.   . . |
tvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgka.karrvvkqyqfveWPdkaverkdsassl

LSMVRTVSSANPPTAG-PMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANK
| ..  |      .|  |..|||.||||||| ..|.||.. .| .| ..|.||.|...|..|  .|||. || |.. |..||...  |...|. 
lklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasy
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1-311 1.2e-61 203.3 In-house 3-267 (392) alignment 
Range on Protein: 1-311
Range on HMM: 3-267/392.0
PIPVEAFAMHVRRMHMDgdIGFSEEYEMVqPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPE
||||  |   | . .      |.||.  . |. . .    . .. |. |||| ||. || .|| |  .. . .|||.|| ||....   |.|||||| . 
pipvaqfpafveknrhs..alffeefhdl.pgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaa

TFDDFWRMVWEQGSAIIVMLTQLEERGrrkcdqywpdrgtrnygalrvtanetfhmsyyvlrtflvshmqEEEEPRQVRQYHYTSWPDHGVPAHPAPLLS
..|||||||...  . |.|.|.|.|                                               .. | | |.|.| |||..|| | . || 
slddfwrmvfqenvttiamvtklkegd...........................................kgddartvaqfhftewPdkdvpkhtssllk

MVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANKLASRIRELR
... |..     . |.|.||||||||||  |..||.. .| .   .||| || ..|.||  ||||. || ||. |..| ..   | .   ... ....| 
fikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdls

EVDPNIGTTYM
      ... .
tssdGdvrskq
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1-96 3.6e-16 53.1 In-house 4-95 (95) alignment 
Range on Protein: 1-96
Range on HMM: 4-95/95.0
PIPVEAFAMHVRRMHMDGDIGFSEEYEMVQPNDeTFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPlegVLESDYINANYIDGYNRSGAFIASQG
|| |  |  ||  || . |  | .|.  ..      ..      ||  |||. ||. || .|| ||      .|||||| ..||| |  ..||.||
pihvsvfhshvlemhsnsdqefdnefksismts.gapytvgsseanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaqg
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 2-318 2.1e-163 537.9 In-house 2-318 (318) alignment 
Range on Protein: 2-318
Range on HMM: 2-318/318.0
IPVEAFAMHVRRMHMDGDIGFSEEYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPET
|.||....||||....|.. .|||||......||.|...||.|.||.|||||||.||||.||.|..|||. .||||||||||||.|. |.||.|.|||||
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

FDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTRNYGALRVTANETFHMSYYVLRTFLVSHmQEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSM
..|||||||||.||.||||||.||||..|...|||..|.|.||.|.|...|....|.||||.| |.. .|||| |||||||||||||.|||...| ||..
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtr.teeeesrqvrqyhytsWpdegvpesgaslldl

VRTVSSAN-PPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANKLASRIRELR
||.||.|. ...|||..|||||||||||.||..|..|.|...|...|||..|.|.|..||||||||.||.||.|.|.||...| |||||..|.|||||||
vrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelr

EVDPNIGTTYMDLEFERL
|.||..|||.||.||.||
eqdpesgttemdaefqrl
subfamily_PTPRG_pd Subfamily PTPRG 2-310 7.7e-125 412.2 In-house 1-313 (563) alignment 
Range on Protein: 2-310
Range on HMM: 1-313/563.0
IPVEAFAMHVRRMHMDGDIGFSEEYE--MVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLES-DYINANYIDGYNRSGAFIASQGPL
.||. || ||  .| |||||||||.|  . . ...... .|| .| || |||| ||||||.||| |.|| |. .. |||||||||||..| ||||.||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

PETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTRNYGALRVTANETFHMSYYVLRTFLVSHMQ-----EEEEPRQVRQYHYTSWPDHGVPA
..||||||||.||| .|||||.|.|.||||||||.|||  .. .||||.||  |. ....|  ||. . ...     . .. ..|||||||.||||||| 
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe

HPAPLLSMVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANKla
|..| |..|.  | ||. .|||..||||||||||||.| ||..|..  || ...||||....| .|| .|||| ||.|.||||.||.  . ||. |..  
hslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeq..

srIRELREVDPNIGTTY
  ..||... | .   |
..veelknctpyleqqy
0039614 (Phosphotyrosine protein) phosphatases II 2-284 1e-99 329.0 In-house 14-293 (297) alignment 
Range on Protein: 2-284
Range on HMM: 14-293/297.0
IPVEAFAMHVRRMHMDGDIGFSEEYEMVQPNDETftWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGV-LESDYINANYIDGYNR-SGAFIASQGPLP
||...............  .. .|.|... . .   . ..|.|.|| |||| .|..|||||| |.|..|| |.||||||.|.|||.. . .|||.|||||
iplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlp

ETFDDFWRMVWEQGSAIIVMLTQLEERGRrKCDQYWPDRGTrNYGALRVTANETFHMSYYVLRTFLVSHmqeEEEPRQVRQYHYTSWPDHGVPAHPAPLL
||..||||||||||. .|||||.|.|.|| ||.||||..|. .|| ..||  ...| ..|..||. |..   ..|.|.|....||.||||||| ... ||
etvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslelll

SMVRTVSSANP--PTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGV
.... | .|.   |  ||..||||||||||||||... ||..   ||..||.  |...|..|. .|||.|||.|..|||.| . ...
eflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
0045450 (Phosphotyrosine protein) phosphatases II 2-280 4e-97 320.9 In-house 9-304 (307) alignment 
Range on Protein: 2-280
Range on HMM: 9-304/307.0
IPVEAFAMHVRRMHMDGDIGFSEEYEMVQPNDE--TFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGV-LESDYINANYI--------DGYNRSGA
|... . ..|.... |.  |. .|.|....      ... ..|.|.|| |||| .|..|||.|| |..|.|   .||||||.|.        |||... .
idalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrk

FIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTR-NYGALRVTANETFHMSYYVLRTFLVSHMQEEEEPRQVRQYHYTSWPDH
||| |||||||..|||||.||||. .|||||.|.|.||.||.||||| |.  .|| ..||  .. |...|..||. |.......|.|.|...|||.||||
fIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdh

GVPAHPAPLLSMVRTVSSANP--PTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGT---IDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAV
||| ....||.... | .|.   |  ||..||||||||||||||... ||..  .|||   .|..  |...|..|  .||...||.|...|| | .
gvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 2-300 4.7e-97 319.8 In-house 4-303 (305) alignment 
Range on Protein: 2-300
Range on HMM: 4-303/305.0
IPVEAFAMHVRRMHMDGDIGFSEEYEMVQPNDETFTWHHslHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPET
| .. .|.... .... | |. ..|.... ..|..  ..  . ||| |||...|. .|..|. ||. | . .||||||.|.|||.|. ..|..||||..|
ialddlaayikearvysdkgleaqykslyeeeesidvgk..keankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlknt

FDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTR--NYGALRVTANETFHMSYYVLRTFLVSHMQEEEEPRQVRQYHYTSWPDHGVPAHPAPLL
 .||||...|     |||||.| | |. || ||||.. |.  ..| . |. ... ..| |. | . .|  .|..| |.| ||. |.|||||||  .. ||
vadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsll

SMVRTVSSANPPTAG-PMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANKLASRIRE
|... |  .     | |..|||||||||||.||..| .|.|. .|...|||. ..|.|.||  ||||  ||||.|||| | ..|| |..  . |  |.  
slikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnk

LR
|.
lk
subfamily_Ptp69D_pd Subfamily Ptp69D 2-299 9.7e-94 308.9 In-house 4-305 (307) alignment 
Range on Protein: 2-299
Range on HMM: 4-305/307.0
IPVEAFAMHVRRMHMDGDIGFSEEYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPET
|...  .  ..  . | | |. .|||... .    . . | .  |. |||| .|.|.|. || |....|  .||||||..| ||. .  |||.|.|. .|
iaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveat

FDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTRNYGALRVTANETFHMSYYVLRTFLVSHMQ----EEEEPRQVRQYHYTSWPDHGVPAHPAP
 .|||||..|| . .||||..|.|  |.||..|||.  . .|| . |.  .. ..|.|. |.. ||...    |.|. |.| |||||.|.|  || ..  
igDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevarg

LLSMVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANKLASRIR
|| ... | . .    .|..|||||||||.|.|..|||.||.  .| ..|.| .|...|..|||.||   ||||.. ||..    | |..| ..|...|.
llklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaie

EL
.|
rl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 2-280 1.7e-79 261.7 In-house 2-283 (290) alignment 
Range on Protein: 2-280
Range on HMM: 2-283/290.0
IPVEAFAMHVRRMHMDGDIGFSEEYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLE--SDYINANYIDGYNRSGAFIASQGPLP
|||. |. .|   |. |. || ....|..  .. .| .. | . || .||.|||| ||  |. | |. |  .   .|||| ||.||. . ..|| |||..
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

ETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTRNYGALRVTANETFHMSYYVLRTFLVSHMQEEEEPRQVRQYHYTSWPDHG-VPAHPAPL
.|  |||...|.. ..||||||.  | |. || |||||..|..||  ... ..  ....|. |.. | ..........| ||. |.|...| |... . |
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtil

LSMVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAV
|.. . .     .. ....||||..|||...|....  .... .|| ||||  ....| ..  .|||. || .|.. .....
lvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 2-288 4.7e-79 260.3 In-house 2-286 (287) alignment 
Range on Protein: 2-288
Range on HMM: 2-286/287.0
IPVEAFAMHVRRMHMDGDIGFSEEYEMVQP-NDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTplegVLESDYINANYIDGYNRSGAFIASQGPLPE
|||| |.  |.. |  |. ||.. . ...  ...     |.. . || |||...|. .|  ||||       . ||||| .||||. . |||....|. .
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfn

TFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTRNYGALRVTANETFHMSYYVLRTFLVSHMQEEEEPRQVRQYHYTSWPDHG-VPAHPAPLL
|  .||......   .||||.|..|  ...| ||||.  .  .|  ...  .  ... |. |.. | . .......||.||..|.|...| |. . . ||
tarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtill

SMVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVD
 . . . .   .. ....||||..|||...|.  .  .... .||.||||  ....| ..  .||| .|| || |...| . .. | .|
vieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysd
0040438 (Phosphotyrosine protein) phosphatases II 4-318 2.7e-107 354.0 In-house 2-314 (317) alignment 
Range on Protein: 4-318
Range on HMM: 2-314/317.0
VEAFAMHVRRMHMDGDIGFSEEYEMVQPNDETfTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFD
|. .  .. .... .  ...||.|... ..   |. ....|.|| |||| .|. |||||| |.||.|.|.||||||.|.||.|.. .||| |||||.|..
vldlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntve

DFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTRNYGALRVTANETFHMSYYVLRTFLVSHMqEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVR
||||||||||. .|||||.|||.||.||.||||...| .|| ..||  .........|||. |... ...|.|.|...|||.||||||| .| .||....
dFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfle

TVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANKLASRIRELREVD
 | .|...  ||..||||||||||||||... ||..  .||..||.  |...|..|. .|||..||.|..||| | . ...| ..|..|.... .| ...
avrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllkllipl

PNIGTTYMDLEFERL
.. . .... |...|
alddvklkekelkll
0050432 (Phosphotyrosine protein) phosphatases II 4-285 1.2e-104 345.2 In-house 28-304 (308) alignment 
Range on Protein: 4-285
Range on HMM: 28-304/308.0
VEAFAMHVRRmhMDGDIGFSEEYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLtpleGvLESDYINANYIDGY--NRSGAFIASQGPLPET
|. .. .. .  ...  ...||.| .. . . ... ..|.|.|| |||| .|..|||||| |    .  .||||||.|.|||  ... .||| |||||.|
vldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPlpnt

FDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDR---GTRNYGALRVTANETFHMSYYVLRTFLVSHMQEEEEpRQVRQYHYTSWPDHGVPAHPAPL
..|||||||||.. .|||||.|.|.|| ||.||||.    |...|| ..||  .. ....|..||. .......|. |.|...|||.||||||| .|..|
vedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdges.rtvthfhytnWpdhgvPpspeil

LSMVRTVSSANPPtaGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVT
|.... | . .|.  ||..||||||||||||||.|| .|..  .||..|||. |...| .|. ||||..||.|...||.| . . .|
ldflelvrkslpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt
subfamily_PTPRK_pd Subfamily PTPRK 4-315 2.9e-102 336.7 In-house 6-312 (314) alignment 
Range on Protein: 4-315
Range on HMM: 6-312/314.0
VEAFAMHVRRMHMDGDIGFSEEYEMVQPNdetftWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFD
|.    ..  ..     || |||| .        |  . .  |. |||. .|.|||.||| |....|  .||||||..||.|.|. |||. ||||.||  
vadllqsiallkraegygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvk

DFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTRnYGALRVTANETFHMSYYVLRTFLVSH-MQEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMV
||||.|.....| |||||.| | || || .|||. ..  || ..|.  ||   . .| |.| |..  .  || |.|||.....||||.|| .   ||..|
dfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklv

RTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANKLASRIRELREV
| | . ....||...|||||| |||||||..|..|. . .||..|||  |...|...  ||.|| ||.||.|...||..|| | . . .. .   |  ..
rrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesirl

DPNIGTTYMDLEF
||.  .. .  ||
dpqtnssqlkeef
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 5-316 5.6e-81 267.2 In-house 8-324 (325) alignment 
Range on Protein: 5-316
Range on HMM: 8-324/325.0
EAFAMHVRRMHMDGDIGFSEEYEMVqPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDD
  .  || . . . . ||. |.... |.|.. . . . .|.|| |||. |.||.|.||| |  ..   .||||||.|.  . .   |.|.| ||..| .|
vnlvehvekkkaqdqdgfahefgll.psddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatind

FWRMV--WEqgSAIIVMLTQLEErGRRKCDQYWPDR--GTRNYGALRVTANETFHMSYYVLRTFLVSHMQEeEEPRQVRQYHYTSWPDHGVPAHPAPLLS
.||.|  |.  ....|.| .|.. |  .| .|||..   ....|.|.|      ..| || | . |  ...  | | |.|... ||.| ||. .|| |.|
lWrlvldWr..csvvvvlneldl.gkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkk.GetrsvkqfqlqswddmGvqkrpatlis

MVRTVSS------ANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANKLAS
....|        ||  ...|..|||||||||||.||.| |.|..  .|  .|.||||...|..|  ||.|  ||..|..|||||...| |.|  . . .
ilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfea

RIRELREVDPNIGTTYMDLEFE
..  |.| .|      .. |||
klsslqernpltqklniekefe
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 6-291 2.1e-69 229.0 In-house 6-290 (439) alignment 
Range on Protein: 6-291
Range on HMM: 6-290/439.0
AFAMHVRRMHMDGDIGFSEEYEMVQPNDETFTWHHSLH--PANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFD
 |  || ... . .  |.|..|...  .  ..   ||     .. |||| ...|.||.|| |  . ||  | |||||||.||     .||.|||  || |
efqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettd

DFWRMVWEQGSAIIVMLTQLEERGRrkcdqYWPDRGTRNYGALRVTANETFHMSYYVLRTFLVSHMQ-EEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMV
||||.|.|. .. |||||.| |  .     |||  .   || . | ..    .  ||.| | |   .   |  | | |.||..|||. |||. . .| ..
dfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldfl

RTVSSANPP-TAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANK
|.. |||     ||..|||||||||||| |.||  |..   |  .|. | |. .|..|. |||.  |||||..|..| .. | . |  ..
rainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtide
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 6-278 2.3e-51 169.2 In-house 16-281 (290) alignment 
Range on Protein: 6-278
Range on HMM: 16-281/290.0
AFAMHVRRMHMDgdiGFSEEY-EMVQPNDETFTWHHSLHPANK--YKNRYANIVAYDHSRVLLTplEGvLESDYINANYIDGYNRsgAFIASQGPLPETF
 || .| .. .|   ... || | ..|   .     ..  .|    |||| ..|  | .||.|   .|  . ||. |||..| .    || .||.| .| 
kfasdvvkknvd...elakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilk..dG.ydGdyvhanyvkGlka..mfiltqGalkdtv

DDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTR--NYGALRVTANETFHMSYYVLRTFLVSHMQEEEEPRQVRQYHYTSWPDHGVPAHPAPLLS
 |.|||| ... | |||| .| | |. ||.||.|..  .   .|.. |.  |  .    . .  |    ...    ... ..  ||||. |.     || 
idiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallr

MVRTVSSAnpptAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVE
..|..  |    .||..||||||.||||||....  ||   .   .|. . || .|| |   || . ||. . ..|..
tlrilrka....sGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_PTPN9_pd Subfamily PTPN9 7-278 4e-86 283.7 In-house 6-288 (297) alignment 
Range on Protein: 7-278
Range on HMM: 6-288/297.0
FAMHVRRMhmdGDIGFSEEYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFW
.  .|. .   |  | |.||. .. .  . | ..| ..||  ||||.... ||..|| |. ...  .|||||||..|||..  |||| ||||..|..|||
lvayvkek...gkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfW

RMVWEQGSAIIVMLTQLEERGRRKCDQYWP--DRGTRNYGALRVTANETFHMSYYVLRTFLVSHMQEEeEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRT
||||||   .||| |...||||.|| ||||  .  . ..| |.|.  |. ... |. |.. ......| | |.|  . ..||||.|||   | || ....
rmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkte.esrkvthfqflsWPdyGvPssaaslldvlek

VS-------------SANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVE
|              .. .|.  |..||||||.||||||||||  |.|  ..||.||.  |...|..|  ..||. ||.| . |..|
vrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 7-278 2.5e-38 126.4 In-house 1-267 (281) alignment 
Range on Protein: 7-278
Range on HMM: 1-267/281.0
FAMHVRRMHMDGdigFSEEYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTP-LEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDF
|||  ..| .|    | .|.  .  .  .       .| |. ||||.|| . | ||| |   .     .||| ||||        .| .|||  ||  ||
famssqkmtldd...fkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradf

WRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGT--RNYGALRVTANETFHmSYYVLRTFLvsHMQEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVR
|||.|.. .. |||| |. |  | || .|.|       ..  | |. ...      .. | |   .  | | | . .. .  |||  ||     .| ..|
wrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstv.nkslvttrl..nlsyegetrlithwlwkewpdwqvpessevmlkilr

TVSSAnpptAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTI-DVFGFVRQMRN-KRNLMVQTESQYVFIHDALVE
 . .     . | ..||||||||.||.....  ||      |. |.   | ..|   |   |||  ||..|   |..
kirar....stppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 9-279 9.7e-99 325.0 In-house 10-278 (288) alignment 
Range on Protein: 9-279
Range on HMM: 10-278/288.0
MHVRRMHMDGDIGFSEEYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRM
 .| ... ..  ||||||. . . ..| . . . .. |. |||| ||..||. || |. || . ..|||||.||||.... ..||.||||..| .|||..
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

VWEQGSAIIVMLTQLEERGRRKCDQYWPDRGT-RNYGALRVTANETFHMSYYVLRTFLVShmqEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSS
|.|. .  |||||.| |.|..||..|||| .. .||| . ||. |. ..  .|||..|.     ... ... ||.|..|||||||.  |||| ..|.|  
vyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkv

ANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEA
||.  .||.|||||||||||||||.|| ....  .| .|||.|.| ..|..|.|.|||..||.||...|.. 
anqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 9-280 1.1e-91 301.8 In-house 4-276 (281) alignment 
Range on Protein: 9-280
Range on HMM: 4-276/281.0
MHVRRMHMDGDIGFSEEYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRM
 |..... . . || |||| ..  .   | . | ...|. |||| ||||||..|| .|| |   ..||||||...||.   ..||.|||.|.....||.|
khlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqm

VWEQGSAIIVMLTQLEERGRRKCDQYWPDRG-TRNYGALRVTANETFHMSYYVLRTFLVshMQEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSS
||||   .|||.|.  | |. || .||||   . .|| ..|. ... . . |. |.| .   .|. |.|.|.| .||.|||||||| .. ||.  . | .
vweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlk

-ANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQE-GTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAV
  .. |  |...|||||||||||.|.|| .......|  ..||   |...|..|||||||  || |.. |...|.
ltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 9-281 1.6e-58 192.7 In-house 7-294 (301) alignment 
Range on Protein: 9-281
Range on HMM: 7-294/301.0
MHVRRMHMDGdigFSEEYEMVQPNDETFTwHHSLHPANKYKNRYANIVAYDHSRVLLTPLEG--VLESDYINANYIDGYNRSGAFIASQGPLPETFDDFW
.||  .| ..   |.|.|. .. ...  . . .|. .||. ||. ||. ||. |..|.| .   . . .||||.|||||... .|||.|||. .|  |||
thvaakhsnk...feeqykelkegedksc.tvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfW

RMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRG--TRNYGALRVTANETFHMSYYVLRTFLV--------------SHMQEEEEPRQVRQYHYTSWPDHG
|..|..  . |||.|.|.|. . || ||||.    . ..| . || ...  .  .|.| . |               ..... ....| |.. |.||..|
rliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdG

VPAHP-APLLSMVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVI
|   |   | ..   .   . .  ||..||||..|.|.|......  |  .  || .|||. .. .| ..  .|.|  ||..|.|.. . . 
vvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq
subfamily_PTPN23_pd Subfamily PTPN23 10-280 1.2e-64 212.9 In-house 5-280 (288) alignment 
Range on Protein: 10-280
Range on HMM: 5-280/288.0
HVRRMHMDGDIGFSEEYEMVQPNDETFTWHHSLHPANKY--KNRYANIVAYDHSRVLLTplegVLESDYINANYIDGY-NRSGAFIASQGPLPETFDDFW
...|  .||  .. .... .. ...  . ..|.  |..|  |||. .|. |||.|| |       . ||||| .. .    .  |||.|.||..|  |||
elqrkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFW

RMVWEQGSAIIVMLTQLEERGRRKCDQYWPDR--GTRNYGALRVTANETFHMSYYVLRTFLVSHMQeEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRT
.||.|| | .||||.. ||.|. |.|.||| .   | ..|.|.|| ... .....| |.. ... . ... ..|.  ..||||..|||| |  || ..  
lmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletld.adavksvshlqltsWpelGvPasPetllqflde

VSS----ANPPTAGPMIVHCSAGVGRTGTFITLDSMLQR-AAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAV
| |     . ..  |..|||||||||||.|  . . ..   ...| .|.   |...|..|  |||...|. |  .| .||.
vesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
0036941 (Phosphotyrosine protein) phosphatases II 13-294 1.6e-100 331.5 In-house 6-291 (297) alignment 
Range on Protein: 13-294
Range on HMM: 6-291/297.0
RMHMDGDIGFSEEYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLtpleGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQ
 .....  ....|.| ..|.   ... ..| |.|. |||| .|..|||.|| |    .  .||||||.|.|||... .||| |||||.|..|||||||||
lekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweq

GSAIIVMLTQLEERGRRKCDQYWPDR--GTRNYGALRVTANETFH--MSYYVLRTFLVSHMqEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSA
.. .|||||.|.|.|| ||.||||.   .. .|| ..||  .. .   ..|.|||. |... ...|.|.|...|||.||||||| .||.||.... | ..
nvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt.gngesrtvthfhytgwpdhgvpespaslldfielvrkv

NP--PTAGPMIVHCSAGVGRTGTFITLDSMLQRAA---QEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANKLAS
..  |  ||..|||||||||.||||..| |||.      ||..|.. .|...|..|. .|||..||.|...|| | . .. | . ..||..
lkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklvl
0047943 (Phosphotyrosine protein) phosphatases II 13-279 6e-99 326.2 In-house 5-271 (273) alignment 
Range on Protein: 13-279
Range on HMM: 5-271/273.0
RMHMDGDIGFSEEYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLtpleGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQ
.....|  .. ||.|..... . .|. ..|.|.|| |||| .|..|||||| |    |  .||||||.|.||||.. .||| |||||.|..|||||||||
lekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

GSAIIVMLTQLEERGRRKCDQYWPDRG---TRNYGALRVTANETFHMSYYVLRTFLVSHMQEEEePRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSAN
.. .|||||.|.|.||.||.||||. |   . .|| ..||  .... ..|..||. ..... .| .|.|...|||.|||||||.....||.... | .|.
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkal

PP--TAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEA
      ||..||||||||||||||.|| .|..   ||..||.  |...|..|  ||||..||.|...||.| 
ealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 13-287 3.1e-97 320.4 In-house 20-297 (298) alignment 
Range on Protein: 13-287
Range on HMM: 20-297/298.0
RMHMDGDIGFSEEYEMVQPNDE---TFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMV
 ..  . .|...|.. ..   .   ..... . .|.|| |||||.|.|.|.|||.|.  ..  ||||||| ....|... ||||.|.||.||. ||||||
vkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmv

WEQGSAIIVMLTQLEERGRRKCDQYWPDRGTRNYGALRVTANETFHMSYYVLRTFLVSHMQEEeEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSaN
.|. .. |||||.||| .. |. .||||.|...|| ..|.  .. ... .. |.. ||. .|| . |.||| |.|||||.|||..   .| ..| |   .
teedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvra.s

PPTAG--PMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEV
.  ||  |.||.|||||||.|||| .||.|.|. .| ..|||  |. .|.||  .||||.|||||..|  ||. .. .|.
qqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_PTPN6_pd Subfamily PTPN6 16-277 2.2e-87 287.9 In-house 22-294 (306) alignment 
Range on Protein: 16-277
Range on HMM: 22-294/306.0
MDGDIGFSEEYEMVQPND--ETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTpLEGVLESDYINANYIDGY--NRSGAFIASQGPLPETFDDFWRMVWE
. .  ||.||.| .| ..  .... ... .| || |||| ||. .||.|| |.  ..| .|||||||||..   . . ..||.|| |..|  |||||||.
slekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwq

QGSAIIVMLTQLEERGRRKCDQYWPDRGT-RNYGALRVTANETFHMSYYVLRTFLVSHMQEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANP
. | .|||.|.  |||. || .||||  . ..|| ..||  .  ....|.||...||......| |.|.|||..||||||||..|  .|.....|.. . 
ensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqe

PTA----GPMIVHCSAGVGRTGTFITLDSMLQRAAQEG---TIDVFGFVRQMRNKRNLMVQTESQYVFIHDALV
 ..    ||..||||||.||||||| .| .|.   ..|    ||.  .|...|. |. .||||.|| |.. |. 
eleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik
0045098 (Phosphotyrosine protein) phosphatases II 20-281 1.4e-89 295.5 In-house 7-273 (278) alignment 
Range on Protein: 20-281
Range on HMM: 7-273/278.0
IGFSEEYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLltplegvlesDYINANYIDGYnrSGAFIASQGPLPETFDDFWRMVWEQGSAIIVM
. .. |.| . .     .. ..| . |..|||| .|..||||||           |||||.|||||  . .||| |||||.|..|||||.||.|. .|||
ldlllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivm

LTQLEERGRRKCDQYWPDRGTRNYGALRVTANETFHMSYYVLRTFLVSHM---QEEEEPRQVRQYHYTSWPDHGVPAHP--APLLSMVRTVSSANP----
||.|.|.|| ||.||||..|. .|| ..||  .. ....|.|||.|| .    .|. |.| |...||..||||||| .|  ...|.... . .|.     
ltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllas

---------PTAGPMIVHCSAGVGRTGTFITLDSMLQRAaqEGTIDVFGFVRQMRNKRNL-MVQTESQYVFIHDALVEAVI
         .  ||..||||||||||||.. .. ||..   ||..|..  |...|..|.  .||...||.|....|.| . 
lllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 20-278 3.6e-39 129.3 In-house 22-285 (305) alignment 
Range on Protein: 20-278
Range on HMM: 22-285/305.0
IGFSEEYEMVQPNDEtFTWHHSLHPA-NKYKNRYANIVAYDHSRVLLtplEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIV
.|. .|.  ..  .. |   .... | .. |||| ..   |. || |   ||    .|| |||.     .  || .| || .|  ||| | ...    | 
aglraefvamkrfnd.fekmkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaif

MLTQLEERGRRKCDQYWPDRGTRN--Y----GALRVTANETFHMSY------YVLRTFLVSHMQeEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVrtvS
|| .| |.| .|| .|.. .      .      . |  . .  ...       | .| ||      |. |.| .||.  ||| ||||    .| ..    
mlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegp.gekarkvthyhwidwpdrgvpaadlailell...e

SANpPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDV-FGFVRQMRNKRNLMVQTESQYVFIHDALVE
 |  |. ||..||||||.||||. . |. .|..  .   |.     ....|..||  .||. ||.|.|. ...
kar.pskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
0046845 (Phosphotyrosine protein) phosphatases II 21-286 4.3e-102 336.6 In-house 1-280 (284) alignment 
Range on Protein: 21-286
Range on HMM: 1-280/284.0
GFSEEYEMVQPNDETF--TWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGV-LESDYINANYIDGY-----NRSGAFIASQGPLPETFDDFWRMVWEQ
|. ||.|... .  ..  .....|.|.|. |||| .|..|||||| |..|.|   .||||||.|.|||     ... .||| |||||.|..|||||||||
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

GSAIIVMLTQLEERGRRKCDQYWPDRG-TRNYGALRVTANETFHMSYYVLRTFLVSHMQEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANP-
.. .|||||.|.|.|| ||.||||. | . .|| ..||  .. ....|..||. ..... ..|.|.|...|||||||||||..|..||...|.| .... 
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

-PTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEG---TIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTE
 |. ||..||||||||||||||.|| .|..  .||   ..||.. |...|..|. ||||..||.|...||.|.. ...| 
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 21-279 1.5e-46 153.6 In-house 7-258 (267) alignment 
Range on Protein: 21-279
Range on HMM: 7-258/267.0
GFSEEYEMVQP-NDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLegvlESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVM
 . .|.|...   |.. |   |.   |. .||. . . ||..|| |       | .|||| |..||..  |||. |.||  |  ||. .. .|. ..||.
eiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtk....eeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivl

LTQLeerGRRKCDQYWPDR--GTRNYGALRVTANETFHMSYYVLRTFLVSHmqEEEEPRQVRQYHYTSWPDHGV-PAHPAPLLSMVRTVSSANppTAGPM
||.    .  .  ..|| .   ...|  | |  .       | . |. .    ..|  ..|  |.|  |        .  ||. ..      |     |.
ltkv...ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkf..knesahnvtlyyykkwnintnnkpylkplfgilaknqlen..gnrPl

IVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEA
.|.||.||||.|||...||.|.|| .||. |.| |.|..|..|  .|.|  .|..||. |.| 
vvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
DSPc_SM00195 22-279 2.4e-93 307.6 In-house 2-261 (263) alignment 
Range on Protein: 22-279
Range on HMM: 2-261/263.0
FSEEYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLT
..||.| .. .... . ... ...|| |||| ||. |||.|| |.. |.  .|||||||||.|.|.. ..|| |||||.|..||||||||... ||||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

QLEERGRRKCDQYWPDR--GTRNYGALRVTANETFHMS-YYVLRTFLVSHMQEeEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPPTAGPMIV
. ||.|..|||.|||.   |. ..| ..|.  |. ...  ..|||. ... .. ||.|.|.||.|..||||||| .. ..|...|.| . .  . ||..|
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEA
||||||||||||.|.|..|.. ..| ..|.|  |...|..|  ||||. || ||..|..|.
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 22-279 2.4e-93 307.6 In-house 2-261 (263) alignment 
Range on Protein: 22-279
Range on HMM: 2-261/263.0
FSEEYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLT
..||.| .. .... . ... ...|| |||| ||. |||.|| |.. |.  .|||||||||.|.|.. ..|| |||||.|..||||||||... ||||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

QLEERGRRKCDQYWPDR--GTRNYGALRVTANETFHMS-YYVLRTFLVSHMQEeEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPPTAGPMIV
. ||.|..|||.|||.   |. ..| ..|.  |. ...  ..|||. ... .. ||.|.|.||.|..||||||| .. ..|...|.| . .  . ||..|
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEA
||||||||||||.|.|..|.. ..| ..|.|  |...|..|  ||||. || ||..|..|.
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
subfamily_PTPN1_pd Subfamily PTPN1 23-282 9.5e-61 200.0 In-house 9-275 (290) alignment 
Range on Protein: 23-282
Range on HMM: 9-275/290.0
SEEYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGvlesDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQ
.| |. .. . . |. ... .|.|. .||| ..  |||||. |   .     |||||. ..  .    .| .|||||.| | ||.||||| |  .||| .
keiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnk

LEERGRRKCDQYWPDRGT---RNY--GALRVTANETFHMSYYVLRTFLVSHMQEeEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSS--ANPPTAGP
. |... || ||||         .    |.|.  .. . |||..|.. .  ..  .| |.. ..|||.||| |||  || .|...  | .  .  .  ||
vvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlkt.qetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGp

MIVHCSAGVGRTGTFITLDSMLQRAAQEGT---IDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVI--C
 ..|||||.||.|||. .|..| .  ...    .|.   . ..|. |  ..||  |  | . |..| .    
avihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvik
subfamily_PTPN13_pd Subfamily PTPN13 24-279 1.2e-69 229.6 In-house 15-268 (273) alignment 
Range on Protein: 24-279
Range on HMM: 15-268/273.0
EEYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGvlesdYINANYIDGY--NRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLT
||.. ..    . | . . . .|| |||| |.. ||..|| |    |     ||||..|     .    .||.||||||| .|||.||||| . .|.|.|
eefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt

QLEERGRRKCDQYWPDRGTRN---YGALRVTANETFHMSYYVLRTFLVSHMQEEeEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPpTAGPMIV
.  |.|. ||..|||..  ..   .. |.|.  .. ... .|.|.. |.... . | |.| . ....|||||||...|.|| .|. | . .   |||..|
lekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesg.esrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivv

HCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEA
|||||.||.||.||.| .|.  ...  .||   ||..|..|. .|||. ||.|.. |..|.
hcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailev
subfamily_PTPN14_pd Subfamily PTPN14 24-278 2.2e-60 199.2 In-house 27-294 (300) alignment 
Range on Protein: 24-278
Range on HMM: 27-294/300.0
EEYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVlESDYINANYIDGY--NRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLT
 ||| .... |  . . .  | |. |||. ... |...|| |.| .   ...||||  |      ..  .|..||||. |  |||.|||||| ..|||||
teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlt

QLEERGRRKCDQYWPDR----GTRNYGALRVTANETFHMSYYVLRTFLVSHMQEEEEpRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANP-------
. || |. |. .|.|.      | ..|  .||.. . . . .. ... . |.  .|| |.|    || |||||||  . . || .. | |          
eeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskee.rtvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseve

--PTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVE
   .  |..|||||||||||  |. | ...   .. .||.   ....|..| |.||| .|| |....|..
skeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik
subfamily_PTPN3_pd Subfamily PTPN3 25-279 3e-74 244.4 In-house 20-274 (280) alignment 
Range on Protein: 25-279
Range on HMM: 20-274/280.0
EYEMVQPNDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLegvlESDYINANYID----GYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVML
..|..   ..  . ...  |.|  |||| .|..||. || |.      |.|||||||..    . . .  .||.||||..|  |||.||||| | .||||
qfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkes....etdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivml

TQLEERGRRKCDQYWPDRG-TRNYGALRVTANETFHMSYYVLRTFLVSHMQEEeEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPPTAGPMIVH
|.| |||| || ||||. . . .|| ..|. ... . . |||| ..... ... | |.. |  |..||||||| ..| .|..|..| ..   .  |..||
ttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketk.eerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvh

CSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEA
||||.|||| .|.|.  |.   ..  . .   ||.||..|  .|||.||| |. .|....
CsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 31-280 7.1e-36 118.7 In-house 29-271 (288) alignment 
Range on Protein: 31-280
Range on HMM: 29-271/288.0
PNDETFTWHHSlHPANKYKNRYANIVAYDHSRVLLTplegvLE-SDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRR
||. .    .| . ||  ..|| |.   | .|| |.      .   ||.|| .   .    .| .| ||  | . .|.|. |..   ||||..| |.|..
pneasidiids.fianptrdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGke

KCDQYWPDRGTRNY--GALRVTANETFHMSYYVLRTFLVSHMQEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANpptaGPMIVHCSAGVGRT
| ..|.| .  ..   | |     .       ...  |.   .| ||.  |.. |.  |.|.|||    . | ..  . | .     |..||.|||||||
ksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslq....kPivvhssaGvGrt

GTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAV
||.|    .|. .  .  . .  .. ..|..|   .||| ||...|  . | .
gtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_PTPN12_pd Subfamily PTPN12 32-281 8.6e-82 269.3 In-house 26-278 (290) alignment 
Range on Protein: 32-281
Range on HMM: 26-278/290.0
NDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKC
...... ... .. |. |||| .|. ||.||| |.  |.. .|||||||.| | . . ..||.|||||.| ||||||.||.   |.||. .. | |. ||
aekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkC

DQYWPDRGTRN--YGALRVTANETFHMS-YYVLRTFLVSHMqeeEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPPTAGPMIVHCSAGVGRTG
..|||..| ..  .|...|| .|  ...  ...||. | .    .| |.|.|.|||.|||||||. . .||.....| . .   . |..|||||||||||
erYWpeegeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtG

TFITLD---SMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVI
| |..|   ..|..   . ..|||  |...|..|. .|||. ||.... |..| | 
tiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_egg_pd Subfamily egg 32-289 9e-30 98.4 In-house 26-282 (307) alignment 
Range on Protein: 32-289
Range on HMM: 26-282/307.0
NDETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERgrRKC
  .  . ....   |. | |   .   | ||| |   .|    |.| ||...|      || .| || .| |||||||...    |||||   |    .|
svdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erc

DQYWPDRGT--RN--YGALRVTANETFHMSYYVLRTFLVSHMQEEEEPRQVRQYHYtSWPDHGVPAHPAPLLSMVRTVSSanpptagPMIVHCSAGVGRT
. |||   .       |.||... .  . .  ..|   .  .  ..| | .  . .  .   .    |  .| ..| .|        |..|..  || ..
eyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg.dvnnssdvysplrvlrklrnlsk.......pvvvqdilGvska

GTFITLDSMLQRAAQEGT--IDVFGFVRQMRNKRNLMVQTESQYVFIHDALV---EAVICGVTEVDA
.|.....  |    .  .    |   |  .| .|.| |..  .|.|..  ..     ||  . |.| 
atlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsakeldv
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 33-277 4.5e-59 194.6 In-house 25-274 (287) alignment 
Range on Protein: 33-277
Range on HMM: 25-274/287.0
DETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTpLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCD
  |.|.. . . |.  |||||... .|..||||.  || | ||||||||. .|..  ||||.|||.. |  ||||.|.|. || ....|.  | .| || 
sstatfkaaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcy

QYWPDRGT-RNYGALRVTA-NETFHMSYYVLRTFLVSHMQEeEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTV-----SSANPPTAGPMIVHCSAGVG
.|||.|      |   |.. . .     |  |.. . ...  .| | |.|... ||||....     |. .|  |      . .   .||..||...|.|
kywPerevPmrvGGysvvlldydikePeygvralrlidlet.rearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiG

RTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALV
|.|.....  ...|  . | .||   | ..|..|. .||.  |. .. .|||
rsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 33-289 4.7e-39 128.8 In-house 41-298 (310) alignment 
Range on Protein: 33-289
Range on HMM: 41-298/310.0
DETFTWHhsLHPANKYKNRYANIVAYDHSRVLLTpLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCD
| ..|..   .  . .||||...|  | ||| |. ..     ||| |||.       .|| |||||  |  |||||.... .  |..| .  | || || 
dssltye..aykkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcv

QYWPDRG-TRNYGALRVTA----NETFHMSYYvLRTFLVSHMQEEEEPRQVRQ-----YHYTSWPDHGVPAHPAPLLSmVRTVSSAnppTAGPMIVHCSA
 |||  | |  || .|||      | | .      ||.   .  .|.| ....      ..  ||| |||      .   | ..       || .|||||
gywpslgvtetygcirvtnlsesseefeicnl.avtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp.qrllaqv...rhgpcvvhcsa

GVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVeAVICGVTEVDA
|..|... ..|.  .... .   .|.   . .....|   .||| ||..|.   . .   | |||  
gkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri.ifargetevae
subfamily_PTPRN_pd Subfamily PTPRN 34-280 9.6e-63 206.6 In-house 44-292 (297) alignment 
Range on Protein: 34-280
Range on HMM: 44-292/297.0
ETFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYI-DGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCD
|  | . . .. |  |||......|||||| |.      .||||||  | |   |. |.||.||||..|  |||.||||||...||.||.||| | ..|.
epstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqck

QYWPDRGTRNYGALRVT-ANETFHMSYYVLRTFLVSHMQEEeEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPPTAGPMIVHCSAGVGRTGTFI
.|||| |.  |..  |    |      |..|.| .  .| . | | | |.|. |||..|||| . .|| . | |  .    . |..||||.|.||||..|
rywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqts.etrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyi

TLDSMLQRAAQE-GTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAV
 .| .|.| ..    ||.   .  .|..|. .|.|..|. |.  |..| |
lidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev
subfamily_CG7180_pd Subfamily CG7180 35-285 1.2e-63 209.5 In-house 31-295 (296) alignment 
Range on Protein: 35-285
Range on HMM: 31-295/296.0
TFTWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRrKCDQY
. .  . |.  |. |||. ..| ||. ||.|. |.|  .|||||| |.|.. .  ..|  ..|  || |.|||.|.....  .|.||.  .  . .. .|
igdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsy

WPDRGTRNYGALRVTANETFHMSYYVLRTFLVSHM---------QEEEEPRQVRQYHYTSWPD-HGVPAHPAPLLS---MVRTVSSAN--PPTAGPMIVH
|| ..  .|| . |   |. ...  . ||| . ..         |.. | | |.....| |.  . ||   . |.    .||..   .   |. ||..|.
wpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvv

CSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVT
.| |..|.| ....|  |. . .|. .|||..|...|..|. .|..  .| .| | | |||.|...
ssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnkd
0040439 (Phosphotyrosine protein) phosphatases II 37-280 4.7e-90 296.7 In-house 2-246 (249) alignment 
Range on Protein: 37-280
Range on HMM: 2-246/249.0
TWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWP
.. ..|.|.|| |||| .|..|||||| |..|.|.  ||||||.|||||... .||| |||||||..|||||.||.|. .|||||.|.|.|| ||.||||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

DRGTRNYGALRVTANETFHMSYYVLRTFLVSHMqEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANP--PTAGPMIVHCSAGVGRTGTFITLD
..|. .|| ..||  .. ....|..||. .... .. |.|.|....||.||||||| ....||.... | .|.   |. ||..||||||||||||||...
lggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaay

SMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAV
 ||..   |...|..  |...|..|. .||...||.|...|| | .
lmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 37-295 2.1e-84 278.6 In-house 52-306 (319) alignment 
Range on Protein: 37-295
Range on HMM: 52-306/319.0
TWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTqleergRRKCDQYWP
.  ..  . || |||. ||.|.|...| | .|.|.  |||||| ...|| |   .||.||||..| .|||||.||. .. ||.||      . || ||||
dqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywp

DRGTRNYGALRVTANETFHMSYYVLRTFLVSHMQEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPP--TAGPMIVHCSAGVGRTGTFITLD
 ..  ...   |  .     . ||.| . .|.  .|.. |...|.|.  |||.||| .|..|. .|. |.  .       ...|||||||||||..|.||
lkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivld

SMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANKLASR
 .|.|  .|  .||. |||..|..|| .||   || ||. ||.|  . | ..|    . . 
vlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpay
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 37-295 3.3e-83 274.5 In-house 16-270 (284) alignment 
Range on Protein: 37-295
Range on HMM: 16-270/284.0
TWHHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTqleergRRKCDQYWP
.  ..  . || |||. .|.|.|...| | .| |.  |||||| .| || |   .||.||||..| .|||||.||. .. ||.||      . || ||||
dqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywp

DRGTRNYGALRVTANETFHMSYYVLRTFLVSHMQEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPP--TAGPMIVHCSAGVGRTGTFITLD
 ..  ...  .|  .     . ||.| . .|.  .|.. |..||.|.  |||.||| .|..|. .|. |.  .       ...|||||||||||..|.||
lkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivld

SMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANKLASR
 .|.|  .|  .||. |||..|..|| .||   || ||. ||.|  . | ..|    ... 
vlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpay
0049772 (Phosphotyrosine protein) phosphatases II 37-279 8.5e-47 155.7 In-house 37-279 (314) alignment 
Range on Protein: 37-279
Range on HMM: 37-279/314.0
TWHHSLHPANKYKNRYANIVAYDhSRVLLtPLEGVLESDYINANYIDGYnrsGAFIASQGPLPETFDDF----------WRMV--WEQGSAIIVM-----
|.  . ...|. |||| .|. .| .|| | | ..|  ||||||.|.||.    .|||.||||..|..||          ||||  ... . .|||     
tilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdev

----------------LTQLEERGrrkcdqywPDRGTRNYGALRvtanetfhmsyyvlrtflvS-------HmqeeeePRQVRQYHYTSWPDHGVPaHPA
                |..| ..|        .    ...  |.                   .              .|.. .|... .||...|  ..
ladelsrLdaAlgKtpllildgng........neptaadlellk...................eelydpelf......erlgikylripvpDgsap.lle

PLLSMVRTVSSAnpPTAGPMIVHCSAGVGRTGTFITLDSMLQRAaqegTIDVFGFVRQMRNKRN-----LMVQTESQYVFIHDALVEA
 ...... . .|  .. || .|||.||.||||||.... .. .      ...   ....|.||       ....  ||.||..|| |.
dfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealley
0037934 (Phosphotyrosine protein) phosphatases II 38-278 1.2e-83 275.7 In-house 2-240 (243) alignment 
Range on Protein: 38-278
Range on HMM: 2-240/243.0
WHHSLHPANKYKNRYANIVAYDHSRVLLtplEGvleSDYINANYIDGYNRsgaFIASQGPLPETFDD----FWRMVWEQGSAIIVMLTQLEERGRRKCDQ
....|.|.|. |||| .|..|||||| |   ||   |||||||.|....|   .||.|||||||..|    ||||.||.|. .|||||.|.|.|| ||.|
fsiallpenlsknrysdilpydhsrvkl...eg...sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPdrGTRNYGALRVTANETFHMSYYVLRTFLVSHMQEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSA--------NPPTAGPMIVHCSAGVG
|||  |. .|| ..||  .. |...|..||.|... ......|.|..|||..||||||| .|..||.... | .         . .. ||..||||||||
ywp..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RTGTFITLDSMLQRAaqegTIDVFGFVRQMRNKRNL-MVQTESQYVFIHDALVE
||||.|... ||..     ..|..  |...|..|.  .|||.|||.|...|| |
RtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 38-140 1.7e-15 51.3 In-house 88-183 (244) alignment 
Range on Protein: 38-140
Range on HMM: 88-183/244.0
WHHSLHPANKYKNRYANIVAYDHSRVLLTplEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERgrrkcDQYWPD
 . .. | | .||| .  . .| .|| |.  .| .   |||| ..    |.  .| .| || .|  |||.|. |.   ..|.|  .||      |.||||
mkdafnpnnswknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpd

RGT
   
sep
0042113 (Phosphotyrosine protein) phosphatases II 39-278 5.9e-89 292.9 In-house 2-241 (245) alignment 
Range on Protein: 39-278
Range on HMM: 2-241/245.0
HHSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDR
 ..|.|.|| |||| .|..|||.|| |.| .| | ||||||.|.|||.... |||.|||||||..|||||.||.|. .|||||..||.|| ||.||||..
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

GTRNYGALRVTANETFHMSYYVLRTFLVSHMqEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANP-PTAGPMIVHCSAGVGRTGTFITLDSML
.. .|| ..||  .. |...|..||. |...  . |.|.|..|||..||||||| ... ||.... | .|   .  ||..||||||||||||||... ||
esltygdftvtllseehlddytvrtlevtnl.gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylml

QRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVE
...  |......  |...|..|  .|||.|||.|...|| |
eqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 39-279 1.6e-46 153.6 In-house 26-294 (297) alignment 
Range on Protein: 39-279
Range on HMM: 26-294/297.0
HHSLHPANKYKNRYANIVAYDHSRVLLtpLEGVLESDYINANYIDGYNRS--GAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWP
  .  ..   |||| .|.|.| .|| |  | .. |.|||||.|.   .      .| .|||| .| ||||..|.||.  .|||...|.| || ||  |||
ssakrnsslrknryrdilatddtrvkl..lrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywp

DRGTRNYGALRVTANETFHMSYYVLRTFLvSH--MQEEEEPRQVRQYHYTSWPDHGVPAH----------------PAP-LLSMVR--------TV--SS
.    .  |  |  .   ..|    | .| .   .   .| |.||   . ||||||||.                   | .|..|          .    
svvqerlkagdvvveflsstsdefdrvil.telqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslr

ANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEA
|. |   ...|||||||||.|  .  | .|..  ..   ||  .....|..|  .|||  |. ...|| .. 
aemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 40-85 8.4e-13 42.4 In-house 41-86 (440) alignment 
Range on Protein: 40-85
Range on HMM: 41-86/440.0
HSLHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGY
 .  | || |||| ||.|||||||.|  ..|| .|||||| ||.| 
iaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi
subfamily_CG42327_pd Subfamily CG42327 42-207 2.4e-35 116.8 In-house 24-192 (319) alignment 
Range on Protein: 42-207
Range on HMM: 24-192/319.0
LHPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSG-AFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDR--
. .. | |.|..|.|   ..|| |       .. |..|.|. ||. .   .||.| .| ..  ||||.|||| | .|| ||.| | | ..| .|.| .  
vPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtket

--GTRNYGALRVTANETFHMSYYVLRTFLVSHMqEEEEPRQVRQYHYtSWPDHGVPAHPAPLLSMVRTVSS
  .|. || ..||  .      |.. |.|. .. ..|| |..  | |  |.. .|||..|.|..|.  | |
ldntslyGdilvtlkgrevkdryaistlllkrv.dkeesrelthywy.kwleaevPaeeaaliamllevrs
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 43-282 5.5e-89 292.7 In-house 6-244 (250) alignment 
Range on Protein: 43-282
Range on HMM: 6-244/250.0
HPANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRkCDQYWPDRGTRN
.|.|| |||||.|.|.|.|||.| . .|  ||||||| ...||. . ||||.||||..|. ||||||.|. |. |||||.|.| ..  . ||||  ....
kpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaek

YGALRVTANETFHMSYYVLRTFLVSHMQEEEEpRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPP-TAGPMIVHCSAGVGRTGTFITLDSMLQRAA
|| ..|.  .. ... |. |.. .|. ....| |.|||.|...||| |||..    | ... | . ..   ..|.||.|||||||.|.||..|..|.|. 
yGdvtvsllskeefadytkrklklskakkade.rivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlk

QEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVIC
.| ..||| .....|..|  .|....||||.. .. .|. .
kekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 43-281 2.6e-42 139.9 In-house 38-278 (307) alignment 
Range on Protein: 43-281
Range on HMM: 38-278/307.0
HPANKYKNRYANIVAYDHSRVLLTpLEGvLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDR-GTR
  ||  |||| .. . |..|.... ..| | |||| |||.    .   ||..|||| .|  .|| |. ..    ..|| .. | .. ||.||||   | .
fsantdknryqdvkcqdkgrivvk.fdg.lasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqk

-NYGALRVT----ANETFHMSYYVlRTFLV--SHMQEEEEPRQVRQYHYTSWPDHGVPAHPaplLSMVRTVSSANPpTAGPMIVHCSAGVGRTGTFITLD
  .|    |       . ...        |   ...  .. | .... .. |||.|||      |. .  ... .     |..|||||||||.|| ... 
lvfgeapntisvanlgakklapde.dlinvttlkvdwaqksrtiqhlqwenwpdrgvpqin...ltainlleavry.dtnpvvvhcsaGvGrsGtivais

SMLQRAAQ-EGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVI
 . ..  . .   |.  .|...|..|.  .||| ||...|  |.|  .
lvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 43-284 9.5e-37 121.5 In-house 32-275 (285) alignment 
Range on Protein: 43-284
Range on HMM: 32-275/285.0
HPANKYKNRYANIVAYDHSRVLLTPlegvLESDYINANYID--GYNRSgAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGT
. ||   ||||.. . . .||.|       . ||| |...   | ..| ..|..|||||||. |||.|....  | ..||  | | |  ||  |.|..  
yeanpdlnryadvrcieetrvvlkn....hdrdyihaswmrmpgkdqs.tyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklg

--RNYGALRVTANETFH--MSYYVLRTFLVSHMQE-EEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPpTAGPMIVHCSAGVGRTGTFITLDS
   ..|   .|  |     ..  .| .. |   ..   ||  . . .   |||.  |    |.. . . |   ||    |. |||||||||| ||. .| 
evvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnp.kekpicvhcsagvgrtatfvgidy

MLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVIC-GV
   |  ..  |...  ||.||  |   ||.  |..|..  |.| .|  ||
atirimenpniemldivremramrfqavqshmqflflyvvlmeyfigegv
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 44-278 7.7e-76 249.8 In-house 26-266 (274) alignment 
Range on Protein: 44-278
Range on HMM: 26-266/274.0
PANKYKNRYANIVAYDHSRVLLTPLEGVLE-SDYINANYIDGYNR-SGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTR
. ...|||| .|.  ..|||||.. ..  | |.||||||| ||.. | |..| |||||.| .|||||.... . .|||||.|.|. ..|| .|.||.   
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

----NYGALRVTANETFHMSYYVLRTFLVSHMQEeeePRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSAN---PPTAGPMIVHCSAGVGRTGTFITLD
    .|| . .. ... .   | .|.........   .|.|  | ||.|||| .| .. .||..|. |....      ..|..||||||.|||| ||. .
eiserygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiais

SMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVE
  ...  .|...||.. | ..| .|  ||||..|| .|| ||..
iavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 45-279 3.3e-75 247.3 In-house 6-239 (239) alignment 
Range on Protein: 45-279
Range on HMM: 6-239/239.0
ANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRS-GAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRgTRNY
 || ||||||||.||||||.|  |     ||||||.|.  |. |  |.||.|| .  .  |||||.|..  ..||||| | |  ..|| |||||  | .|
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tsky

GALRVTANETFHMSYYVLRTFLVSHMQEEEEpRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQE
  ||||  .|  .. |..|||..|.. . || | | |||.| |||.||| . . .| . | ..  . | | | ..||||||||||.|. .|.||..| ..
cnlrvtlrktevfadyiirtfvmsqvgqtee.ryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

GTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEA
 |.|.| .|. .|. |  ||||  |||||| |..||
ktvdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 45-278 1.1e-74 245.6 In-house 7-239 (239) alignment 
Range on Protein: 45-278
Range on HMM: 7-239/239.0
ANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNRS-GAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRgTRNY
 || ||||||||.||||||.|  |     ||||||.|.  |. |  |.||.|| .  .  |||||.|..  ..||||| | |  ..|| |||||  | .|
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tsky

GALRVTANETFHMSYYVLRTFLVSHMQEEEEpRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQE
  ||||  .|  .. |..|||..|.. . || | | |||.| |||.||| . . .| . | ..  . | | | ..||||||||||.|. .|.||..| ..
cnlrvtlrktevfadyiirtfvmsqvgqtee.ryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

GTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVE
 |.|.| .|. .|. |  ||||  |||||| |..|
ktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 45-278 5.4e-69 227.0 In-house 2-237 (237) alignment 
Range on Protein: 45-278
Range on HMM: 2-237/237.0
ANKYKNRYANIVAYDHSRVLLTPLEGVleSDYINANYIDGYNRS-GAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRG-TRN
 || ||||.||||||||||.|    .   ||||||.|..|.. .   .||.||||  . ||||.|||..  ..||||| | |. . || .|||.    . 
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGALRVTANETFHMSYYVLRTFLVSHMQEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANP--PTAGPMIVHCSAGVGRTGTFITLDSMLQRA
|| | |.     ..| | .|..|.|. .. .| | . ||..|||||.||| . | || . . .   .|  . .|| |.|||||||||| |. .|.||..|
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

AQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVE
 ..  .|.. .|  . . |  ..||. ||||||....|
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 45-295 1.8e-60 199.3 In-house 32-281 (283) alignment 
Range on Protein: 45-295
Range on HMM: 32-281/283.0
ANKYKNRYANIVAYDHSRVLLTPLEGvlesDYINANYID---GYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTR
 || |||. .||..|  || | ..      ||||| .|     |...  .|..|.|| .|  |||.||...  . |||||.| |  | || |||| ||. 
enkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGse

NYGALRVTANETFHMSYYVLRTFLVSHMQEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAA
.|| . || .. .    .. . .|. .    ..   .  | .  | . |  |    |. . . .|  .    ||..||||.|.|||..||.. . .. | 
dyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdal

QEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTEVDANKLASR
 |  .|||  |. ||..|  .|||  || ..|.. .|  .|| |.. | .| | 
tesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdlqst
subfamily_ptpA1_pd Subfamily ptpA1 45-239 1.5e-44 147.4 In-house 46-255 (418) alignment 
Range on Protein: 45-239
Range on HMM: 46-255/418.0
ANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYNrSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTRNYG
 |  ||||.||.  .|.|| |  ..    |||||||||||      ||..|||||.|  ||||||||.   |||||..  |  | |||.|||..   .  
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqf

ALRVTANETFHMSYYVL--------RTFLVS--HMQEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSAN----P--PTAGPMIVHCSAGVGRTG
..    || |      |        |  .    ..  | | |.. ||.|  |||| .| |  |.  ......  .    |      |.||||||||||||
siygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtg

TFITLDSMLQR
|| |   |...
tfctavimmkk
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 45-281 9.5e-20 65.4 In-house 46-280 (303) alignment 
Range on Protein: 45-281
Range on HMM: 46-280/303.0
ANKYKNRYANIVAYDHSRVLLTplegvlESDYINANYIDgYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRG-TRNY
 |  |||.....  |||.| |.      .| || |.|..  . |   | .| ||. |  |||.|. ||    ...|    |  .   |  .|      ..
knmdknrfvdvicldhskvkls......dssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

G--ALRVTANETFH-MSYYVLRTFLVSHMQeeeEPRQVRQYHYTSWPDHGVPAHPAPL-LSMVRTVSSA-NP-PTAGPMIVHCSAGVGRTGTFITLDS-M
   ..||        .  .||.   ||  .       .  .|| .||   .|.. .|  .  .  . |       . | .    .|.||.|||  ...  
eersirvgefkrvelgdgwvlkvlsvsngd...yksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetah

LQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVI
|   ... ..|.   . ..|| |   ||  ||. ...  | | |.
lslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 45-277 2.7e-16 53.9 In-house 50-282 (302) alignment 
Range on Protein: 45-277
Range on HMM: 50-282/302.0
ANKYKNRYANIVAYDHSRVLLTplegVLESDYINANYIDGYNRSGAFIASQGPLPETF---DDFWRMVWEQGSAIIVMLTQLEERGRrKCDQYWP-DRGT
.|  ||.  .. ..|. .| |.      . .|.||  ..  . .   | .| |  ..    ..|||||...  . .|.| . ||  .   ....|   |.
knlkknqsedvpildsnlvkle....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgd

-RNYGALRVTANETFHMSYYVlRTFLVSHMQEE-EEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQ
  .||...|      ...  .   . .  . |.  .   .  |. | |... || . | |   .  |   . ..  ....    |.|| |.|.||   ..
ykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavave

RAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALV
.  ..    .   |...|..|  .|.. .|||... ||.
klqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 45-196 5e-10 32.6 In-house 26-159 (169) alignment 
Range on Protein: 45-196
Range on HMM: 26-159/169.0
ANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINAnyidgynrsgafiasqgplpetfddfwRMVWEQGSAIIVMLTQLEERgrrkcDQYWPDRGTRN--
.|. ||| |  .|  | || |  .   | ||||||                           ||.||  ...||.| . ...     ...||..   .  
cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddk.....nnfwpekedyqlh

---------YGALRVTANETFHMSYY---VLRTFLVSHMQEEEEPRQVRQYHYTSWPDHGVPAHPA
           .| | ..     .     ..   .| |  ...   ... .||..||. |||  | 
pavilgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqspv
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 45-196 5.8e-10 32.3 In-house 25-158 (169) alignment 
Range on Protein: 45-196
Range on HMM: 25-158/169.0
ANKYKNRYANIVAYDHSRVLLTPLEGVLESDYINAnyidgynrsgafiasqgplpetfddfwRMVWEQGSAIIVMLTQLEERgrrkcDQYWPDRGTRNYG
.|. ||| |  .|  | || |  .   | ||||||                           ||.||  ...||.| . ...     ...||..   .  
cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddk.....nnfwpekedyqlh

AlRVTANETFHMSYYV---------------LRTFLVSHMQEEEEPRQVRQYHYTSWPDHGVPAHPA
   |   | .  | ||               .   || |  ...  .|.. .||..||. |||  | 
p.avilGewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspv
Y_phosphatase Protein-tyrosine phosphatase 46-278 9.4e-90 295.5 Pfam-A 1-235 (235) alignment 
Range on Protein: 46-278
Range on HMM: 1-235/235.0
NKYKNRYANIVAYDHSRVLLtplEGVLE-SDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWP--DRGTRN
|| |||| .|..||..|| |   .|  . ||||||||..||... .|||.||||..|..|||||||.. . .|||||.|||.||.||.||||  .... .
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGALRVTAN-ETF-HMSYYVLRTFLVSHMQEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRA
|| ..|.   ..  ... |.||.. ... .||.|.|.|.|.|||.|||||||..| .||...| | . . .. ||..|||||||||||||..|| .|...
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

AQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVE
 .|...||. .|...|..|. |||...||.|...|..|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 46-278 9.4e-90 295.5 In-house 1-235 (235) alignment 
Range on Protein: 46-278
Range on HMM: 1-235/235.0
NKYKNRYANIVAYDHSRVLLtplEGVLE-SDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWP--DRGTRN
|| |||| .|..||..|| |   .|  . ||||||||..||... .|||.||||..|..|||||||.. . .|||||.|||.||.||.||||  .... .
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGALRVTAN-ETF-HMSYYVLRTFLVSHMQEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRA
|| ..|.   ..  ... |.||.. ... .||.|.|.|.|.|||.|||||||..| .||...| | . . .. ||..|||||||||||||..|| .|...
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

AQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVE
 .|...||. .|...|..|. |||...||.|...|..|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 46-278 1.6e-64 212.5 In-house 20-262 (270) alignment 
Range on Protein: 46-278
Range on HMM: 20-262/270.0
NKYKNRYANIVAYDHSRVLLTPLEGVLESDYINANYIDGYN-RSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGT----
.|  ||||.|.   ..|| | .||   .. ||||||. |.. .. ..||..|||| |  .||||.||. .  |||.|.|||.||.||..||| .      
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

RNYGALRVTANETFHMSYYVLRTFLVShmqEEEEPRQVRQYHYTSWPDHGVPAHPA------PLLSMVRTV--SSANPPTAGPMIVHCSAGVGRTGTFIT
 ..| ..|.| .. ... |.|.   .    |. | |..  ..|..||||||| ..        ||.|.|.|  |. .   |.|..||||||||||||.|.
ledgkikvlalseekeegyiltrlrle...ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlia

LDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVE
|| ...   ... .||   ....|..|  .||.  || |.. |.||
lDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
0041856 (Phosphotyrosine protein) phosphatases II 46-286 1.8e-55 182.6 In-house 1-177 (182) alignment 
Range on Protein: 46-286
Range on HMM: 1-177/182.0
NKYKNRYANIVAYDHSRvlltplegvlESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTqleergrrkCDQYWPdrgtrnyga
|. |||| .|. |||||           .||||||...|. ..  ||| ||||..|. ||.||..|.|  .||.||         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

lrvtanetfhmsyyvlrtflvshmqeEEEPRQVRQYHYTSWPDHGVPAhPAPLLSMVRTVSSanppTAGPMIVHCSAGVGRTGTFITLDSMLQRaaqegT
                          |...|.. ||.|..|||||||  .  ||.....| .      || .||||||||||||.. .. |...      
..........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....g

IDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVICGVTE
....  |...|..|. ||.|..||.|...|| | . ...|.
vsleeavklvrsrRpgmvitpnqyfflqlallellllkktr
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 46-280 2.1e-37 123.4 In-house 55-289 (305) alignment 
Range on Protein: 46-280
Range on HMM: 55-289/305.0
NKYKNRYANIVAYDHSRVLLTPLEgvlESDYINANYIDGY-NRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDR-GT---
.. ||||... . |.| |.|        |||| |||.         ||..|||| .| |.|| || ..    |||| .  | |. || ||||   |    
aitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

RNYGALRVTANETFHM--SYYVLRTFLVSHMqEEEEPRQVRQYHYTSWPDHGVPahPAPLLSMvrTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQ
 . | .      .  |     .  | |   .   ..   ||. ..| ||| |||  |. | |.   . ||   .  |..||||||.||||| .... .|.
lksgivvenvsgskpmerdaeiqitllnlty.sgdqkmsvrhlqwtewpdrgvp..pckltsl..ellsairgskvpivvhcsagigrtgtivaieyile

RAAQEGTI-DVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAV
. |..     .  .|. .|..|   .|.. ||.|||  ... .
kiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 46-139 1.5e-14 48.2 In-house 34-126 (332) alignment 
Range on Protein: 46-139
Range on HMM: 34-126/332.0
NKYKNRYANIVAYDHSRVLLTPLEGvlESDYINANYIDGYNRSGAFIASQGPLPETF-DDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRG
|   ||   . ..||||| |.| .|  . |. ||...|||..  |.| .| |. .     ||||| |.  ..|... ...|. .||.     |||
nmdmnriphlycfdhsrvelapqdg..kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapydisdrg
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 46-114 1.2e-09 32.2 In-house 37-110 (347) alignment 
Range on Protein: 46-114
Range on HMM: 37-110/347.0
NKYKNRYANIVAYDHSRVLLTPLEGVLE-----SDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGS
.  |||  .    | .||.|.| .           |||| .|   | |  .| .| |||.|  |||.||     
slsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkv
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 47-280 5e-28 92.7 In-house 44-276 (312) alignment 
Range on Protein: 47-280
Range on HMM: 44-276/312.0
KYKNRYANIVAYDHSRVLLTPLegvlESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDR-GTRNYGA
|  ||| ||  .|  |  |.      |  || ||..    .   |...|||| .|   ||...   ||. |..|. . | |  || .|  |  |  .   
kdlnrypniqcwdrgrftlagd....enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdled

LRVTANE----------TFHMSYYVLRTFLVSHMQEeeepRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSanppTAGPMIVHCSAGVGRTGTFITLDS
 || ..             .... ||.  . .  ||     .. .| ..||||||.|      | .. .|         |.| |||||||||||.. ..|
hrvyteycteieiggkskdkithrvlkvvvkatgqe....sklnhyqwaswpdhgmpdscdtalrllsavkk....dkkpviahcsagvgrtgtlalies

MLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAV
|.    .    .|      .|. |   |..  |||.   ...| .
miaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefl
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 48-277 6.8e-21 69.7 In-house 21-256 (290) alignment 
Range on Protein: 48-277
Range on HMM: 21-256/290.0
YKNRYANIVAyDHSRVLLTPLEGVLESDYINANYIDgYNRSGAFIASQGPLPET-------FDDFWRMVWEQGSAIIVMLTQLEERGRR----KCDQYWP
 ..|... ..  ..|| |      . .||| ||..  .    ..|..| |. ..         .|| |. .  .  .||| . ||. .      | .| |
mdqRlevpLv.eatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvp

DRGT--RNYGALRVTANETFHMSYYVLRTFLVSHmqEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSAnpptAGPMIVHCSAGVGRTGTFITLD
..     ... | |   .  .      |. .| .  ..||. .|  . . .| .  |. ..  |||....|         |.||||  |. |  .. ...
esvgeelkfkgltvkCkskekeddvetRelvvkf..ddeeeftvtHsllkgWnklnvqedtktllsliqkvkas....ktpvivHcvdGiSrsAalaaii

SMLQRAA-QEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALV
   |  | ..| . .   . ..|..|.|..... .. |.  ..|
lgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 48-147 2.2e-17 57.4 In-house 50-162 (349) alignment 
Range on Protein: 48-147
Range on HMM: 50-162/349.0
YKNRYANIVAYDHSRVLLT--------------PLEGVLESDYINANYID--GYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKC
 |||| .|. |.|||| |                 ..    |||||||.    ..    .|| | ||| | |||....  .|  ... |.. .| . .||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

DQYWPDRgtrNYGALR
|.|| .    .|   .
diywqel...sysnit
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 49-143 4.5e-26 86.4 In-house 50-158 (350) alignment 
Range on Protein: 49-143
Range on HMM: 50-158/350.0
KNRYANIVAYDHSRVLLT----PLE----GVLESDYINANYIDGY----NRSGA--FIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQY
|||| ||. |.|||| |     . .     .  .|||||||.       .      .|| |.|||.|.|||.... . .  .|..||.. | ...||..|
knrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrY

WPDRGTRNY
|.. .  ..
Wqegsyddi
subfamily_eak_pd Subfamily eak 49-280 1.5e-18 61.3 In-house 55-305 (332) alignment 
Range on Protein: 49-280
Range on HMM: 55-305/332.0
KNrYANIVAYDHSRVLLTPLEgVLESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRG--TRNYGAL
.|   .|| ||.  | ||.     .  ||||  ..  .    .| .  .  .    ||.|| || |  ||.| .  | .  | |.|.||..    ..| |
rn.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGil

RVTANETFHMSYYVLRTFLVSHMqeeEEPRQVRQYHYTSWPDHGVPAHP-------------APLLSMVR-T-VS------SANPPTAGPmIVHCSAGVG
 |.  |  . . .  | . .|     .|  .|  |..  | .  .|                ..||  .. . .|         ||.  | |. .. |  
dverkefvkrniletrllelskG...nethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfap.iiqsarGsa

RTGTFITLDSMLQRA--AQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAV
|.|.|. .| ...     .. .  |  .. ....||.  | .. |. ||...... .
raGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyl
0044763 (Phosphotyrosine protein) phosphatases II 58-275 5.5e-42 138.7 In-house 2-166 (178) alignment 
Range on Protein: 58-275
Range on HMM: 2-166/178.0
YDHSRVLLTPLEGVLESDYINANYIDGYnrsgAFIASQGPlpetfDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTrnygalrvtanetfhms
.|..||||..|||.. ||||||..|...     ...|..|      |......|.|   ||.||.  |.|. |||.|||..                   
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

yyvlrtflvshmqeeeeprqvRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRaaqegTIDVFGFVRQMRN
                      ||... .||||||  .. .| .|. . .| ..  || .|||||||||.||.. .. |...      ....  ....|.
.....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvre

KRNlMVQTESQYVFIHDA
.|. .|....|. .... 
rRp.ivpnpgqlrqLyef
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 58-190 1.3e-09 32.5 In-house 5-125 (130) alignment 
Range on Protein: 58-190
Range on HMM: 5-125/130.0
YDHSRVLltplegvlESDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERgrrkcDQYWPDRGTRNYGALRVTANETFHMS
.. ||.         . .||||...   .|.  .. .| || .|  |||.|. |.   ..|.|  .||      |.||||    ..   ...   | .  
fevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdrde

YYVLRTFLVSHMQEEEE-PRQVRQYHYTSWPDHG
.  ...  .   ..  |  . .  .. . ||  |
fknikasnleiesdlneshqaltmfqisnwpsdg
0046846 (Phosphotyrosine protein) phosphatases II 67-276 4.8e-46 152.0 In-house 5-169 (176) alignment 
Range on Protein: 67-276
Range on HMM: 5-169/176.0
PLEGVLESDYINANYIDGYnrsgAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTRNYgalrvtanetfhmsyyvlrtflv
.|   | .||||||.|.|.    ..|| |||||.|. ||..|..|.|  ..|.||.. | || ||..|||.  . ..                       
llgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

shmqeeeeprqvrQYHYTSWPDHGVPAHpAPLLSMVRTVSSANPPTaGPMIVHCSAGVGRTGTFITLDSMLQraaqEGTIDVFGFVRQMRNKRN-LMVQT
             ||... ||||||| . . ||.... . .|     || .||||||.|||||.. .. .      |  ..|.  ....|..|   .|||
.............qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqt

ESQYVFIHDAL
..|| |.....
peQyrflyefe
0051429 (Phosphotyrosine protein) phosphatases II 74-301 1.7e-63 210.1 In-house 4-245 (272) alignment 
Range on Protein: 74-301
Range on HMM: 4-245/272.0
SDYINANYIDGYNR---SGAFIASQGPLPETFDDFWRMvWEQGSAIIVMLTQLEERGRRKCDQYWP------------DRGTRNYGALRVTANETFHMSY
|.||||....||.|    |....|.|||| | .||||. .|.|   ||.|...||||| |||.|||            .  | .|||||||  .......
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

YVLRTFLVSHMQEEEEPRQVRQYHYTSWPDHGVPAHPapLLSMVRTVSSanpptAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTID--------VFG
|.||..|....   .|.|.|...|||.||||||| ..  ||.... . .      ||..||||||..||||.. |. .|..   |  .|        ...
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlylee

FVRQMRNKRNLMVQTESQYVFIHDALVEAvICGVTEVDANKLASRIRELRE
.|...| .|  .|||| ||.|...||.|. ......|.|. |.. .....|
aveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaaldaide
0036282 (Phosphotyrosine protein) phosphatases II 74-274 4e-53 175.0 In-house 2-164 (174) alignment 
Range on Protein: 74-274
Range on HMM: 2-164/174.0
SDYINANYIDGYNRSGAFIASQGPLPetfddFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDrgtrnygalrvtanetfhmsyyvlrtflvshmQEEE
||||||...|.. ... .||.||||.     ||.|..|.|. ..|||....|.|. || .|||.                                  | 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lred

EPRQVRQYHYTSWPDHGVPAHPApLLSMVRTVSSANPP-TAGPMIVHCSAGVGRTGTFITLDSMLQRAAqEGTIDVFGFVRQMRNKRNLMVQTESQYVFI
. | . ||.|. |||||||  .  ||..|. | .|      ||..||||||||||||.. .. ||..   |...|.. .||..|..|  ||||.||| |.
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

HD
..
yy
0043147 (Phosphotyrosine protein) phosphatases II 74-273 8.7e-48 157.6 In-house 5-154 (172) alignment 
Range on Protein: 74-273
Range on HMM: 5-154/172.0
SDYINANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLeergrrkcdqywpdrgtrnygalrvtanetfhmsyyvlrtflvsHMQEEE
||||||.|.|.|     ||| ||||..|..|||||..|.|  .||.||.|                                                | 
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lydpel

EPRQVRQYHYTSWPDHGVPaHPAPLLSMVRTVSS-ANPPTAGPMIVHCSAGVGRTGTFITLDSMLqraaqeGTIDVFGFVRQMRNKRNLMVQTESQYVFI
. |.. ||.|..||||||| ... ||.... . . ..    ||..||||||||||||.. .. ||        ....  |...|.||. .||..||| |.
lerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrfl

H
.
y
0051082 (Phosphotyrosine protein) phosphatases II 74-276 6.7e-40 131.4 In-house 3-149 (151) alignment 
Range on Protein: 74-276
Range on HMM: 3-149/151.0
SDYINANYIDGYnrsgaFIASQGPLPetfdDFWRMVWEQGSAIIVMLTQLEERGrrKCDQYWPDRGtrnygalrvtanetfhmsyyvlrtflvshmqeee
|||||..|..|.     ...|.|||.    ||.....|.|   ||.|...||||  .| .|.|. |                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

epRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSanpPTAGPMIVHCSAGVGRTGTFITLDSMLQRaaqegtIDVFGFVRQMRNKRNLMVQTESQYVFIH
  ..|.......|||.|.| ... .|.... . .   .  ||..||||||.|||||.. |. ||..      ....  ....| ||  .||.. |..|..
..ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

DAL
 ||
fal
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 77-272 2.3e-32 106.9 In-house 78-273 (301) alignment 
Range on Protein: 77-272
Range on HMM: 78-273/301.0
INANYIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGTRNYG----ALRVTANETFHMSYYVLRTFLVSHMQEE
| ||.|.   ..  |||.||||..| .||| |.       ||||.|  |.  .||..| | . ...       .... .|.      . ||. |    ..
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

EEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANpptaGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFI
 ..| |  | |..|.|.|||   | |  ..  |  ..     |..||||||.||. .||. . . ..   . ||..   ....|..|   |||.||  ..
fatrtvthyqysewtdrgvPkshaelfdlmelvkkse....kPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywm
0049260 (Phosphotyrosine protein) phosphatases II 81-274 1.1e-45 150.3 In-house 1-144 (152) alignment 
Range on Protein: 81-274
Range on HMM: 1-144/152.0
YIDGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWpdrgtrnygalrvtanetfhmsyyvlrtflvshmqeeeeprqvrQ
.||||... .||| |||.|.|..|||||..|.|  .|||||.|.|.|. ||.||.                                            |
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................q

YHYTSWPDHGVPAHPAPLLSMVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLqraaqeGTIDVFGFVRQMRNKRNLMVQTESQYVFIHD
|... ||||||| ..  || ... .  ..    || .||||||||||||.. .. ||        .... .|...|.||. .|....|. |...
ylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 83-177 2.6e-11 37.5 In-house 230-322 (440) alignment 
Range on Protein: 83-177
Range on HMM: 230-322/440.0
DGYNRSGAFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERgrrKCDQYWPDRG-TRNYGALRVTANETFHMSYYVLRTFLVSHMQEEEEPRQ
.|| .  ||||.| ||  |  ||||.| .   . |.|| ||...    |  |||    .  .| . |  . .  |    .||. . . .|  | ||
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevheirq
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 90-273 1.7e-24 81.1 In-house 6-197 (199) alignment 
Range on Protein: 90-273
Range on HMM: 6-197/199.0
AFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWP--DRGTRNYGALRVTANETFHMSYYVLR-TFLVSHMQEEEEPRQVRQYHYTSW
 .||.| || ||. |||.|||| ||  |||. . .         |||  . || .||.| ||..     . |..    |..        |.. .| .|||
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PDHGVPAHP--APLLSMVRTVSSA-NPPTAGPMIVHCSAGVGRTGTFITLDSMLQRA--AQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIH
 ..  |       ..   | ||   .     |.||||| | | || |..||  ..    ..   .|.|   ...|. |  .. .  .| ||.
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 90-273 1.8e-24 81.0 In-house 5-196 (198) alignment 
Range on Protein: 90-273
Range on HMM: 5-196/198.0
AFIASQGPLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWP--DRGTRNYGALRVTANETFHMSYYVLR-TFLVSHMQEEEEPRQVRQYHYTSW
 .||.| || ||. |||.|||| ||  |||. . .         |||  . || .||.| ||..     . |..    |..        |.. .| .|||
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PDHGVPAHP--APLLSMVRTVSSA-NPPTAGPMIVHCSAGVGRTGTFITLDSMLQRA--AQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIH
 ..  |       ..   | ||   .     |.||||| | | || |..||  ..    ..   .|.|   ...|. |  .. .  .| ||.
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 97-276 8.8e-23 75.2 In-house 99-284 (302) alignment 
Range on Protein: 97-276
Range on HMM: 99-284/302.0
PLPETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDR--GTRNYGALRVT---ANETFH----MSYYVLRTF-LVSHMQEEEEPRQVRQYHYTSW
|  .| . .| .. .   ||.| |... | . .|| .|. |.  |. ..|   |.    .. ..       ..| |  .  . .... .. |   ....|
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDHGVPAHPAPLLSMVRTVSSANpptaGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDAL
|||| |... . | ...   |        ..||||||||||||....   .|  ... . |.   |  .|. |   ||.|.| ...   .
pdhGapkeaytaldilkfcesyk....knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcv
subfamily_hpo-7_pd Subfamily hpo-7 100-281 1.3e-20 68.5 In-house 45-228 (263) alignment 
Range on Protein: 100-281
Range on HMM: 45-228/263.0
ETFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDR--GTRNYGALRVTANETFHmsYYVLRTF-LVSHMQEEEEPRQVRQYHYTSWPDHGVPAHPA
.| | |....  ...  .|||.  .| |. ||..|.|    . . .  . |.. .. .    .|.|  |.| ..|  . ..|..| |. |...  |  . 
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelar

PLLSMVRTVSSANpptagPMIVHCSAGVGRTGTFITLDSMLQ------RAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVI
  | ... .         ...||||.|.||.  |   ... |      . .. . .|   .....|..|.  ..|  |  |    ... |.
eilnilkvarnsk.....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvl
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 101-280 2.4e-24 80.8 In-house 40-221 (255) alignment 
Range on Protein: 101-280
Range on HMM: 40-221/255.0
TFDDFWRMVWEQGSAIIVMLTQLEERGRRKCDQYWPDRGT--RNYGALRVTANEtfHMSYYVLRTF-LVSHMQEEEEPRQVRQYHYTSWPDHGVPAHPAP
| | |....  ...  .|||. ..| |. ||..|.|      . .  . ||. .   ..  ||||  ..|.. |  . ..|. |.|. |...  |  .  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

LLSMVRTVSSANpptagPMIVHCSAGVGRTGTFITLDSMLQ------RAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAV
.| ... |  .      ...||||.|.||. .|.  ... |      . .. . .|   .....|.||.  ..|  |  |    ... |
ilnilkvvrdsk.....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
0048076 (Phosphotyrosine protein) phosphatases II 134-276 2.9e-28 93.7 In-house 2-139 (145) alignment 
Range on Protein: 134-276
Range on HMM: 2-139/145.0
YWPDRGTRN--YGALRVTANETFHMSYYVLRTFLVSHMQEEEEpRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPPTaGPMIVHCSAGVGRTGTFI
|||.. . .  .| | .. .  .  .. . . . .....| .| |.. ||.|..|||||||  .. ||.... . .| .   ||..||||||||||||..
ywpseilpglylgslptaldlellkdlgittvlnltselelle.rlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlv

TLDSMLQraaqEGtIDVFGFVRQMRNKRNLMVQTESQYVFIHDAL
 .. ||.    .| ....  ....|..|  .|....|. |.....
aaylmll....lg.vsleealelvrsqrpgavpnpgqlrflyefe
0048179 (Phosphotyrosine protein) phosphatases II 170-274 2.6e-26 87.5 In-house 41-139 (144) alignment 
Range on Protein: 170-274
Range on HMM: 41-139/144.0
QEEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPPTaGPMIVHCSAGVGRTGTFITLDSMLqraaQEGtIDVFGFVRQMRNKRNLMVQTESQY
  |.. |.. ||....||||||| ... ||.... . .| ..  ||..||||||||||||..... |.     .| ....  ....|..|  .|....|.
epefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgql

VFIHD
 |...
rfLle
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 171-277 1.6e-10 34.9 In-house 213-341 (349) alignment 
Range on Protein: 171-277
Range on HMM: 213-341/349.0
EEEEPRQVRQYHYTSWPDHGVPAHPAPLLSMVR-------TVSSA---NPPTAGPMIVHCSAGVGRTGTFITLDSMLQ--RAAQ---------EGTID-V
..|.| .. |  .  |.| ..   |  .|  .        .  .    .     ...|||||| ||||...|||..|.     |           . | .
avekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDli

FGFVRQMRNKRNLMVQTESQYVFIHDALV
.  | ..| .|  |||  .|...|..||.
siivnelrkqrismvqnlaqfiaiyealL
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 173-319 3.1e-35 116.3 In-house 86-233 (440) alignment 
Range on Protein: 173-319
Range on HMM: 86-233/440.0
EEPRQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSS-ANPPTAGPMIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVF
 | | ..|||| .|||.|||   .|.| |.. |.   .    ||..||||||.||||  |..||.|. | .   ||.| |.  |||.|  ||||  ||.|
iesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

IHDALVEAVICGVTEVDANKLASRIRELREVDPNIGTTYMDLEFERLT
.|.|..|...|| | .  . .. |. ...  .|.   . .. |||  .
vheavlegllcgdtliledditerveqiqwpnphtdksplqqefegys
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 174-277 5.5e-16 53.2 In-house 213-341 (350) alignment 
Range on Protein: 174-277
Range on HMM: 213-341/350.0
EPRQVRQYHYTSWPDHGVPAHPAPLLSMVR-------TVS---SANPPTAGPMIVHCSAGVGRTGTFITLDSMLQ-----RAAQ---------EGTID-V
.|  | | ..  |.| ..  .|  .|...        .       .   . |..||||||||||||..||||.|.     .  .           | | .
dPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDli

FGFVRQMRNKRNLMVQTESQYVFIHDALV
.  | ..|..|  |||.  |..||..|| 
siivnelrkqrismvqnldqfifiYeall
PTEN_1 175-262 2.6e-06 22.4 In-house 91-177 (196) alignment 
Range on Protein: 175-262
Range on HMM: 91-177/196.0
PRQVRQYHYTSWPDHGVPAhPAPLLSMVRTVSSANP--PTAGPMIVHCSAGVGRTGTFITldSMLQRAAQEGTIDVFGFVRQMRNKRNLM
 ..  .|.  ...|||.|   . |. ... . ..    |  .  .||| ||.||.|| .   . | .. .    . . .||..| .... 
fksgveylhfpieDhgaps.lselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva..ayLmykgkltadeAlelvrekRppgapn
subfamily_PTPDC1_pd Subfamily PTPDC1 176-274 2.3e-09 31.9 In-house 81-170 (182) alignment 
Range on Protein: 176-274
Range on HMM: 81-170/182.0
RQVRqYHYTSWPDHGVPAhPAPLLSMVRTVSSANppTAGPMIVHCSAGVGRTGTFITLDSMLQRAaqegtIDVFGFVRQMRNKRNLMVQTESQYVFIHD
...  ..  .|.|.||..    .| .|. |..|   . | . ||| || ||||  |.   . ..      ..    .. .|.||   .|| .|  ....
qgiy.vynfgwkDygvas.leriLdivkvvafal..qegkvavhChaGlGrtGvliacylvyakr.....ltaekaiklvrskrpksiqtreqvelvke
0038934 (Phosphotyrosine protein) phosphatases II 176-233 8.5e-08 27.6 In-house 77-135 (194) alignment 
Range on Protein: 176-233
Range on HMM: 77-135/194.0
RQVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANP-PTAGPMIVHCSAGVGRTGTFITL
.   .|.   .||.|..   . ||. .. |   .   . |   ||| ||.|||||..  
kagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa
PTPc_DSPc_SM00012 177-277 9.9e-38 123.9 In-house 1-104 (105) alignment 
Range on Protein: 177-277
Range on HMM: 1-104/105.0
QVRQYHYTSWPDHGVPAHPAPLLSMVRTVSSANPPTA--GPMIVHCSAGVGRTGTFITLDSMLQRAAQE-GTIDVFGFVRQMRNKRNLMVQTESQYVFIH
.|..||||.||||||| .. ..|...| | . .   .  .|..|||||||||||||..|| .||.  .| ...|.| .|...|..|. ||||| ||.|..
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

DALV
.|| 
rall
subfamily_CDC14_pd Subfamily CDC14 200-257 8.5e-06 19.8 In-house 250-305 (328) alignment 
Range on Protein: 200-257
Range on HMM: 250-305/328.0
SMVRTVSSANPPTAGPMIVHCSAGVGRTGTFITLDSMLQraAQEGTIDVFGFVRQMRN
..|.   ..   . | ..||| ||.|||||.|.   | .   .  . .. ...| .| 
aivkkfleiaekaeGaiavhCkaGLGrtGtLiacylmkh..yrftaaeaiawlricrP
subfamily_CG42327_pd Subfamily CG42327 212-276 6.7e-14 46.3 In-house 246-311 (319) alignment 
Range on Protein: 212-276
Range on HMM: 246-311/319.0
TAGPMIVHCSAGVGRTGTFITLDSMLQRAAQE-GTIDVFGFVRQMRNKRNLMVQTESQYVFIHDAL
  ||..|||| ||||||. |. |  ...  .   ..|.   | ..|. |   |.|  || ||.  |
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 216-282 2.7e-21 69.7 In-house 1-67 (69) alignment 
Range on Protein: 216-282
Range on HMM: 1-67/69.0
MIVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVIC
|.||||.| |||||||..   . |   |  .|.|  |. ||  | .||  | .|.|||||||||.  
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealkl
subfamily_PTEN_pd Subfamily PTEN 216-272 6e-06 21.4 In-house 117-172 (184) alignment 
Range on Protein: 216-272
Range on HMM: 117-172/184.0
MIVHCSAGVGRTGTFITLDsMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFI
..||| || ||||. |.   .|..   | . ..  .  ..| | .  |.  ||  ..
vvvHCkaGkGRtGvlivay.llkslllekaeealelfaeaRtknkkgvtiPsqrRYv
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 217-282 6.2e-20 65.3 In-house 1-66 (69) alignment 
Range on Protein: 217-282
Range on HMM: 1-66/69.0
IVHCSAGVGRTGTFITLDSMLQRAAQEGTIDVFGFVRQMRNKRNLMVQTESQYVFIHDALVEAVIC
.||||.| |||||||..   . |   |  .|.|  |. ||  | .||  | .|.|||||||||.  
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealkl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 283-577 2.8e-102 337.0 In-house 1-297 (298) alignment 
Range on Protein: 283-577
Range on HMM: 1-297/298.0
GVTEVDANKLASRIRELREVDPNIGTTYMDLEFERLTRDER--HPTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKA
| ||..|..|   ...| .|... . | ..|||.||.. .   . .. . |  . |  |||||.|.... .|| |.   ..  ||||||||... .. .|
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

YIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSDGSRLYDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGL
.||||||...|.||||||..|.....|||||  || .|.|.|.|||..|.. |..| |.| .. ...|.. |.. .....|...| |||.. | ||| | 
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgv

PESGVGLIDLIGQVEKWQQQSGNTCITVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLESFDLYA
||    ..||. .|...|||.||. ..|.|| ||||.| |.|.. ..||||.|  .||||.|. || .||..|||..|| |.|. ..|.|.||. ..
penatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_PTPN6_pd Subfamily PTPN6 285-572 9.9e-82 269.3 In-house 2-299 (306) alignment 
Range on Protein: 285-572
Range on HMM: 2-299/306.0
TEVDANKLASRIRELREVDPNIGTTYMDLEFERLTR-DERHPTQFKSAMLSCNAAKNRYANILPYERTRVALHmRPGEVGSDYINASFIDGNH--RLKAY
|.. |... .|..||.. . ... . .  |||.| . ....  . | .    |. |||| ||||.. ||| |. .|. .|||||||..|...     |.|
tsllakeieqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksy

IATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSDGS-RLYDKILVELTEELTYSDYVLRQFSLTH-TEEKSSRIVRQFQCTDWPDSG
||||  .. | .|||||.|...| ||||.|.| | || || ||||.  . . | || |. ..| . .||.||..|... ...|..| |.|.. ..||| |
iatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhg

LPESGVGLIDLIGQVEKWQQQSG---NTCITVHCSGGVGRTGVFCAVSILIERVKAEGL---IDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLES
 |..   ..|.. .|.. |...    .  | |||| |.|||| |  . ||.. .. .||   ||. ..|. .| ||  .|||..|| | |..|..|.|.
vpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
0051299 (Phosphotyrosine protein) phosphatases II 286-570 9.6e-100 329.0 In-house 4-286 (288) alignment 
Range on Protein: 286-570
Range on HMM: 4-286/288.0
EVDANKLASRIRELRevdpNIGTTYMDLEFERLTRDERHpTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQ
|.....|......|.      |.|..  |||.|..   .  ....|.| .|  |||| .||||...|| |.. .|. ||||||||.||| .. ...||||
eisveellklvlkll....angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatq

APVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSDGSRLYDKILVELTEELTYSDYVLRQFSLTHT----EEKSSRIVRQFQCTDWPDSGLP
.| | |.||||||.|||.. ||||||...| |. ||..|||..||  |..| |.|..| ...||..|.. .|..     .. ||.|..|..|.||| | |
gPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvp

ESGVGLIDLIGQVEKWQQqSGNTCITVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
.|   |.|.. .| |... ||. .. |||| ||||||.|.|. .|.|....|| .||...|..|| ||| |||| .||.|.| .. |||
dspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 298-579 2.5e-76 251.4 In-house 9-287 (287) alignment 
Range on Protein: 298-579
Range on HMM: 9-287/287.0
ELREVDPNIGTTYMDLEFERLTRDERHPTQFKSAMLSCNAAKNRYANILPYERTRVALHmrpgEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWR
|. . ... | .     |  | . .... .   .. | |  |||...||...  || |.    .   |||||.|||| .  ||.|....|. .|  .||.
efvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWk

MLWEQESAVIVMLTREEEAGKLKCHRYWPSDGSRLYDKILVELTEELTYSDYVLRQFSLTHTE-EKSSRIVRQFQCTDWPDSG-LPESGVgLIDLIGQVE
......  .||||..|.|  . .|..|||.. | .. .  .||..| ....|. |.. ..... ... . |.|.| |.|.. | ..|     . .| .  
liddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqt.illvieemy

KWQQQSGNTCITVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLESFDLYANF
| |...||| | |||| .|||...|||. . |...| || ||||| ... | |.| .||| .||.| .  ..|||.||..|..|
ktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf
0050432 (Phosphotyrosine protein) phosphatases II 299-577 4.1e-100 330.3 In-house 32-306 (308) alignment 
Range on Protein: 299-577
Range on HMM: 32-306/308.0
LREVDPNIGTTYMDLEFERLTRDERhPTQFKSAMLSCNAAKNRYANILPYERTRVALhmrpgEVGSDYINASFIDGN--HRLKAYIATQAPVPRTFEDFW
|. ... ....... |||.|..    . ....|.| .|  |||| .||||...|| |     . ||||||||..||   .. ...||||.| | |.||||
lkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFw

RMLWEQESAVIVMLTREEEAGKLKCHRYWPSD---GSRLYDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQ
||.|||.. ||||||...| |. ||..|||..   ||. |.|. |.|..| ...||..|.. ||..... ||.|..|..|.||| | |.|   |.|.. .
rmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflel

VEKWQqqsGNTCITVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLESFDLYA
|.|..   ..  | |||| ||||||.|.|. .|.|....|| .|||..|..|| ||| ||||..||.|.| ...|||...  ..
vrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltkl
0039614 (Phosphotyrosine protein) phosphatases II 301-571 2.1e-93 308.3 In-house 24-290 (297) alignment 
Range on Protein: 301-571
Range on HMM: 24-290/297.0
EVDPNIGTTYMDLEFERLTRDERhPtqFKSAMLSCNAAKNRYANILPYERTRVALHMRPGE-VGSDYINASFIDGNHR-LKAYIATQAPVPRTFEDFWRM
 ...  ..|...||||.| .    .  .. |.| .|  |||| .||||...|| |.. .|   .|||||||..|| ..  ...||||.| | |.||||||
llekansktllllefeellslkp.d..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrm

LWEQESAVIVMLTREEEAGKlKCHRYWPSDGSrLYDKILVELTEELTYSDYVLRQFSLTHteEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQ
.||| . ||||||...| |. ||..|||..|.  |... |.|... ....|..|....|.  .. ||.|..||.|.||| | |.|   |.... .|....
vweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvreal

QQS-GNTCITVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLE
... ..... ||||.||||||.|.|  ...|... || .||...|..|| ||| .||| .||.|.|  ..|.| 
aelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk
0047943 (Phosphotyrosine protein) phosphatases II 302-570 2.1e-94 311.3 In-house 5-272 (273) alignment 
Range on Protein: 302-570
Range on HMM: 5-272/273.0
VDPNIGTTYMDLEFERLtRDERHPTQFKSAMLSCNAAKNRYANILPYERTRVALhmrpGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWE
...  |.|.. .|||.| ..  ..  .. |.| .|  |||| .||||...|| |    |. ||||||||..|| .. ...||||.| | |.||||||.||
lekllgltllleefell.lslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvwe

QESAVIVMLTREEEAGKLKCHRYWPSDG---SRLYDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQ
| . ||||||...| |. ||..|||..|   |  |.|. |.|..| |..||..|.. ||... . ||.|..|..|.||| | |.|   |...| .|.|..
qnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkal

QQS-GNTCITVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
... .|. . ||||.||||||.|.|. .|......|| .||...|..|| ||| |||| .||.|.| .. |||
ealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Ptp69D_pd Subfamily Ptp69D 303-571 1.4e-83 275.5 In-house 19-287 (307) alignment 
Range on Protein: 303-571
Range on HMM: 19-287/307.0
DPNIGTTYmdlEFERLTRDeRHPTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQ
|.. | .    |.|.| .    . . | .    || |||| .| ....||| |.  .|.  ||||||||| | .  | .|| |.||  | .|||||..||
dtdfglak...eyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeq

ESAVIVMLTREEEAGKLKCHRYWPSDGSRLYDKILVELTEELTYSDYVLRQFSLTHTEEKS-----SRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKW
|. .||||. ..|  . ||..||| .    |..|||.| .| . |||. |........|.|     || | |.. | |.||  ||.  ||..|| ||.. 
evtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrel

QQQSgNTCITVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLE
.... .. |.|||| ||||.|.| |...|....|||  .|.|.||..|| ||. .||  .||.|.|  . .| .
ykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
0036941 (Phosphotyrosine protein) phosphatases II 304-575 6.5e-94 309.8 In-house 8-282 (297) alignment 
Range on Protein: 304-575
Range on HMM: 8-282/297.0
PNIGTTYMDLEFERLtRDERHPTQFKSAMLSCNAAKNRYANILPYERTRVALhmrpGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQE
. ......  |||.|  .  ..  .. |.| .|  |||| .||||..||| |    .. ||||||||..|| .. ...||||.| | |.||||||.||| 
kllflalllkefeel.lpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqn

SAVIVMLTREEEAGKLKCHRYWPSD--GSRLYDKILVELTEELT--YSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQ
. ||||||...| |. ||..|||..  .|  |... |.|... .  ..||.||.. .|.|... ||.|..|..|.||| |.|||   |.|.| .|.|...
vtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlk

QS-GNTCITVHCSGGVGRTGVFCAVSILIERVK---AEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLESFDL
.. ... . ||||.||||.|.|.|. .......    || .|....|..|| ||| .||| .||.|.| ...|.| ....
llpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 306-570 5.6e-21 69.2 In-house 23-285 (302) alignment 
Range on Protein: 306-570
Range on HMM: 23-285/302.0
IGTTYMDLEFERLTRDeRHPTQFkSAMLSCNAAKNRYANILPYERTRVALHMRPgevgSDYINASFIDGNHRLKAYIATQAPVPRTF---EDFWRMLWEQ
. |. .  ||...    . ...    .   | .||.  ..  .. ..| |...|     .|.||| ..  .  .  | .| |.  .    |.|||| ...
ldtaevkkefkkidtm.kvdlek.Ckafkknlkknqsedvpildsnlvkleaep....dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqe

ESAVIVMLTREEEAGKlKCHRYWP--SDGSRLYDKILVELTEeLTYSDYVLRQFSLTHTEEK--SSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVeKWQ
. . .|.| .|||  |   . ..|  |.    |.|. |       ...    ....    |    | ..    .| |...  |..   ||  . .|   .
kivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrk.VekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv.fak

QQSGNTCITVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
.....  . .    |.|| |.| .. . .|.....    . ..|. .| |||..|.. .|| . | ..  |.
kikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 307-578 5.1e-142 467.6 In-house 18-288 (318) alignment 
Range on Protein: 307-578
Range on HMM: 18-288/318.0
GTTYMDLEFERLTRDERHPTQFKSaMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAV
|..... |.|||.|.|...|..|| . ..|.|||||||||.|..|||.|.|. ||.|||||||..|||..| |||||.|||.|.|.||||||.|||.|||
Gelllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsav

IVMLTREEEAGKLKCHRYWPSDGSRLYDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSGNTCI
|||||.|||.|| |.||||||.||| |.|. |||.||...||||||.|..|.|||..||.|||...|.|||.|.||||..|.||..||.|.||.||...|
ivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpi

TVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLESFDLYAN
.||||.||||||||.||.||.||.|||.|.||||||..|| ||..||||.|||||.|....|.|.|.|....
vvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevd
0043336 (Phosphotyrosine protein) phosphatases II 307-570 1.8e-92 305.0 In-house 18-277 (278) alignment 
Range on Protein: 307-570
Range on HMM: 18-277/278.0
GTTYMDLEFERLTRDERhpTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAV
. | . ||||.|..       .. |.| .|  |||| .||||...|| |.. .|. .|||||||..|| .. ...||||.| | |.||||||.||. . .
lktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtt

IVMLTREEEAGKLKCHRYWPsDGSRLYDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQqSGNTCI
|||||...| |. ||..||| .||  |... |.|..| ...||..|.. .|.. .. ||.|.......||| |.|||   |.|.. .| .... . |...
ivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpv

TVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
 ||||.||||||.|.|. .|.|... || .|....|..|| ||| .||| .||.|.|  ..|||
lVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_PTPN23_pd Subfamily PTPN23 307-569 2.4e-70 231.6 In-house 13-279 (288) alignment 
Range on Protein: 307-569
Range on HMM: 13-279/288.0
GTTYMDLEFERLTR-DERHPTQFKSAMLSCNAAKNRYANILPYERTRVALHmrpgEVGSDYINASFIDGNH-RLKAYIATQAPVPRTFEDFWRMLWEQES
|.| .| .|. |.. ....  ..  |.  ... |||. .||||...|| |.    .   |||||||. .       .|||||| . |  |||.|..|| |
gktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqks

AVIVMLTREEEAGKLKCHRYWPSD--GSRLYDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEK---WQQ
 |||||. .|| || |..||||.|   .  .... | | .. . . .| |...|.. ...  . |.  | | ||. |.|.|   |......||.    .|
sviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavq

QSGNTCITVHCSGGVGRTGVFCAVSILIERV-KAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEY
.  .| . |||| ||||||||. |   .. . | .||.|. | |..|| ||  |||.|.|..|.|  . |.
rksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 308-571 1.5e-71 235.8 In-house 18-278 (315) alignment 
Range on Protein: 308-571
Range on HMM: 18-278/315.0
TTYMDLEFERLTRDErhPTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVI
|. .  ||  |   .  . . ..|  . |  |||| ||||....|| | .   .  |||||||.| . .  |||||.|.| . . .|||||..... . |
talfseefhdlpdPd..iyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvtti

VMLTREEEAGKLKCHRYWPS--DGSRLYDKILVELTEELTYSDYVLRQFslTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWqQQSGNTC
||.|  .|  |.|| .|||     |  . .| ||| .  . .| | |..  .  . ..|| | ||| |.||| | ..    |. || .|    ... .  
vmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefs

ITVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLE
. |||| |||||||....   ....| .  .|||..|. || .|| .|||...| | | ...|.| 
llvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_PTPN14_pd Subfamily PTPN14 308-571 7.2e-62 204.1 In-house 22-297 (300) alignment 
Range on Protein: 308-571
Range on HMM: 22-297/300.0
TTYMDLEFERLTRDERhPTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEvGSDYINASFIDG--NHRLKAYIATQAPVPRTFEDFWRMLWEQESA
 . .  |.||... .   .....| |  || |||. ..|||| .|| |     .  ..||||| |      . . ||..|.|.. | .|||.|.|||. .
egkvfteyeripkkre.dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvq

VIVMLTREEEAGKLKCHRYWPSDGSR----LYDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQS
.|||||.||| || |...|.|...|.     ..|  |      . . .. ... | |   |  | |  .| ||||| |.||   | .. . .|.  ....
livmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrkt

GNTC--------ITVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLE
 ..         . |||| |||||||   . .||. .. .  ||. .....|| ||  .|||  ||.| |... .||.
nseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 308-570 1.1e-38 128.0 In-house 15-277 (307) alignment 
Range on Protein: 308-570
Range on HMM: 15-277/307.0
TTYMDLEFERLTRdeRHPTQFKSAMLSCNAAKNRYANILPYERTRVALHMrPGeVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVI
 . .  ||. |..  . |       .|.|. |||| ..   ...|. ... .| . |||| | ..    . | .|..| |   |  .|| |  ...   .
vqalvdefrvlak..ktpegvtveafsantdknryqdvkcqdkgrivvkf.dg.lasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesv

VMLTREEEAGKLKCHRYWPSD-GSRL-YD----KILVE-L-TEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQq
.|| .  | .|.||..||| . | .| .      | |. | ...|.  . ..   .|     . || ....| ..||| | |.  .. |.|.  |.  . 
imlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydt.

qsgnTCITVHCSGGVGRTGVFCAVSILIER-VKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
      . |||| ||||.|   |.|.. .. .. .   |. . |. || ||.  .||. || . .  . ||.
....npvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
0040438 (Phosphotyrosine protein) phosphatases II 309-573 1.2e-95 315.7 In-house 18-279 (317) alignment 
Range on Protein: 309-573
Range on HMM: 18-279/317.0
TYMDLEFERLTRDERHptQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIV
|..  |||.| .   .   .. |.| .|  |||| .||||...|| |.  .|  .|||||||..|| .. ...||||.| | |.||||||.||| . |||
talleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtviv

MLTREEEAGKLKCHRYWPSDGSRLYDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQqSGNTCITV
|||..|| |. ||..|||....  |... |.|..| ......||.. ....... ||.|..|..|.||| |.|.|   |.|.. .|..... ...... |
mLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlV

HCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLESF
|||.||||||.|.|. ...|... || .||...|..|| ||| .||| .||.|.|. ..|||  .
HCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk
0045450 (Phosphotyrosine protein) phosphatases II 309-570 1.1e-89 296.4 In-house 27-304 (307) alignment 
Range on Protein: 309-570
Range on HMM: 27-304/307.0
TYMDLEFERLTRDERH-PTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGE-VGSDYINASFI--------DGNHRLKAYIATQAPVPRTFEDFWRM
| .  |||.| . . . .  ...|.| .|  |||| .||||..||| |.  .|.  .|||||||..        || .. ...||||.| | |.||||||
tgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrm

LWEQESAVIVMLTREEEAGKLKCHRYWPSDGSR-LYDKILVELTEELTYSDYVLRQFSLTHT-EEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEK
|||| . ||||||...| |. ||..|||..|.   |... |.|..| ....|..|.. .|.. ... ||.|..|..|.||| |.|.|   |.|.| .|.|
lweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrk

WQQQS-GNTCITVHCSGGVGRTGVFCAVSILIERVKAEGL---IDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
..... ..... ||||.||||||.|.|  ........||    .|....|..|| ||| .||. .||.|.|  ..|.|
aleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 309-567 2.6e-81 267.8 In-house 21-276 (288) alignment 
Range on Protein: 309-567
Range on HMM: 21-276/288.0
TYMDLEFERLTRDERHPTQfKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIV
| .  |.. |.  |.. .. . . |. || |||| |||||. .|| |.  . | |.||||||.|||... |.|||||.|.. | .|||.. .|...  ||
tgfseeynsLaalektksv.tagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstiv

MLTREEEAGKLKCHRYWPSDGS-RLYDKILVELTEELTYSDYVLRQFSLThtEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSgNTCIT
|||   | || ||..|||...  ..| .. |.|.|. .  |.|||.. |    .|. . . |.| . ||| | |||   |..|. ||.  .|.     |.
mltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.tgpii

VHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQ
|||| ||||||.| |.  ||..|..|  |||. ||..|| ||. .|||. ||||.| .. 
vhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 309-568 1.1e-76 253.3 In-house 34-289 (319) alignment 
Range on Protein: 309-568
Range on HMM: 34-289/319.0
TYMDLEFERLTRDERHPTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIV
| .  || |...     .. . | |  |  |||. |||......| |.   || .||||||||..|  | . |||.| | . | .|||||.||.... ||
tklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstiv

MLTreeeagKLKCHRYWPSDGSRLYDKILVELTEELTYSDYVLRQFSLTH-TEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQ-QSGNTCI
.||      | || .||| ..   ...  |...     ..||.|.. |.. ..||  | ..||    ||| | |.... |. |. .|.. .. . ... |
llt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhrani

TVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQE
 |||| |||||||. .. .|..|.| |  .||...|. || ||. .||   || |.|... |
vvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 309-571 5.4e-70 230.9 In-house 18-277 (515) alignment 
Range on Protein: 309-571
Range on HMM: 18-277/515.0
TYMDLEFERLTRDERHPTQfkSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIV
| .  ||  |   . .|     |    |  |||| |||||...|| | .   .  |||.|||.| . .  |||||.|.| . . .||||...... . |.
tlfseefhdlpgpniypqt..vaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttia

MLTREEEAGKLKCHRYWPS--DGSRLYDKILVELTEELTYSDYVLRQFSLTHTEEksSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSGnTCI
|.|. .|  | || .|||     |  . .| |||    . .. . |.. ... ..  || | ||. |.||| | |.    |. || .|   ..|     .
mvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpl

TVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLE
 .||| |||||||....   . ..|    .|||..|. .| .|| .|||..|| | | ...|.| 
iihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 310-571 8.3e-67 220.0 In-house 11-278 (287) alignment 
Range on Protein: 310-571
Range on HMM: 11-278/287.0
YMDLEFERLTRDE-RHPTQFKSAMLSCNAAKNRYANILPYERTRVALHmRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIV
 .| |...|..|    .  ||.|    .. |||||..||.. ||| |    || ||||||| .. . .. .|.||.|.|.. |  ||||...|..||...
dvdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvi

MLTREEEAGKLKCHRYWPSDG--SRLYDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQV----EKWQQQSG
..||| | ..|||..|||      |.    .| |  .    .|  | . | . | . .|.|.|..  .||| .|. . |||| .. .|    |  .. |.
tmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardase

NTCITVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLE
   . ||.. |.||.|.. |. .|..| .  | .|| ..| .|| .| |.||.  |. . | ..  | .
vGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 310-578 8.9e-63 206.8 In-house 16-301 (301) alignment 
Range on Protein: 310-578
Range on HMM: 16-301/301.0
YMDLEFERLTRDERHPTQFKsaMLSCNAAKNRYANILPYERTRVALHMRPG--EVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVI
 .. ....|.. | .... .  . . |.| ||. || .|.  |. |.  |       .|||||.|||  . |..||.|.|. .|  ||||..|..  . |
kfeeqykelkegedksctvg..lseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsi

VMLTREEEAGKLKCHRYWPS--DGSRLYDKILVELTEELTYSDYVLRQFSL---------------THTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDL
||.| ..|  | ||..|||.    |  . .. |.|..| .| |.|.||...                 ...|||. | |.| ||||. |.       .  
vmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqv

IGQVEKWQQQSGNTCITVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLESFDLYAN
| .| . ||. |   . |||| .|.|.||.|.||| .| .|||| .|||| .. .| ..| .|.| .|| . |  |..||.  . |||
iddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan
subfamily_PTPRG_pd Subfamily PTPRG 311-572 6.3e-82 270.6 In-house 21-289 (563) alignment 
Range on Protein: 311-572
Range on HMM: 21-289/563.0
MDLEFERLTRDERHP-TQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGS-DYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIV
.. ||| |..   .   . ...   .|  |||| ||..|.|.|| |.  ||. .. |||||..||| .. ||.|||| |.. ||.|||||.|||..|.||
fseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiiv

MLTREEEAGKLKCHRYWPSDGSRLYDKILVELTEELTYSDYVLRQFSLTHTE--E----KSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQsG
|.|  .| |. ||..|||.|.|  |... | |.|| . . |  |.... ...  .    .. . |||...|.||| | ||. .  .  . . .. ...  
mitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaanka.e

NTCITVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLES
   |.|||| ||||||...... |......|  ..||....|.|.||. .|||..|| | . ...| . |
aGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
subfamily_PTPRN_pd Subfamily PTPRN 311-569 9.4e-67 219.8 In-house 31-291 (297) alignment 
Range on Protein: 311-569
Range on HMM: 31-291/297.0
MDLEFERLTRDERHPTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFI-DGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVM
.. |.| |.. | .|.  . |    |. |||....|||. .|| |. .  .  |||||||.| | . |  ||||||.|.. |  |||.|.||| ..|||.
lekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivn

LTREEEAGKLKCHRYWPSDGSRLYDKILVELTEELTY-SDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQsGNTCITV
||| || |  .|.|||| .|| .|.   |.|  |  .  ||..| | |   . . .| | ||    ||..| | |   |...  .|.|  .    . | |
ltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG.rscpivv

HCSGGVGRTGVFCAVSILIERV-KAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEY
|||.|.|||||.... ....|. |    ||.  |..||| ||| .|.||||.||..|.. | 
hcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 311-568 1.8e-60 199.3 In-house 8-264 (283) alignment 
Range on Protein: 311-568
Range on HMM: 8-264/283.0
MDLEFERLTRDERHPTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGevgsDYINASFID---GNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVI
..| .|.| |    . . . |. . |  |||. .|.|... || |.  .     |||||.||     ... | ||..|.|. ||  |||.|..... . |
nklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitai

VMLTREEEAGKLKCHRYWPSDGSRLYDKILVELTEELTYSDYVLRQFSLTHT-EEKSSRIVRQFQCTDWPDSGlPESGVGLIDLIGQVEKWQQQSGNTCI
||||.  |  . || .|||..||  | .  | | .| |   .. ... | .    ||. ..  .|  || . | ... .  .  . .|   |..| .. |
vmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleyg.eqaiinslvkfnkvislqteskkgPi

TVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQE
 |||| |.|||.||.|.|  .. ...| ..|||..|. .| ||. .|||.||| . .. . |
vvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 311-570 2.9e-50 165.8 In-house 22-236 (392) alignment 
Range on Protein: 311-570
Range on HMM: 22-236/392.0
MDLEFERLTRDERHPTqfKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVML
.  ||  |   . .|.  ..|    |  |||| |||||...|| | .      |||.|||.|.. .  |||||.|.| . ...|||||..... . |.|.
ffeefhdlpgpdiypq..tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamv

TREEEAGklkchrywpsdgsrlydkilvelteeltysdyvlrqfslthtEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKwQQQSGNTCITVHC
|. .|.                                             .. | | ||. |.|||...|.    |. .| .|.  .  .    . .||
tklkegd..........................................kgddartvaqfhftewPdkdvpkhtssllkfikevka.dfGqythpliihc

SGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
| |||||||  ..  .. . |   ..|||. |  .| .|| |||||.|| | | .. | |
sagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 311-571 6.9e-44 144.9 In-house 8-260 (267) alignment 
Range on Protein: 311-571
Range on HMM: 8-260/267.0
MDLEFERLTRDERHPTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEvgsdYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVML
.. ||| ...     ..    . . |...||. . |||. ||| |  .  |    |||||...| .. .|.|.|| |.  |  ||. .. .|. .|||.|
iekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivll

TReeeAGKLKCHRYWPSD--GSRLYDKILVELTEELTYSDYVLRQFSLTHTEEkSSRIVRQFQCTDWPDSGlpESGVGLIDLIGQVEKWQQQSGNTCITV
|.   ... . ...||     .. |. . || . |    || .  . |   .| |.. |  .    |      .    |  |.| . | | . ||  . |
tk...vftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfkne.sahnvtlyyykkwnint..nnkpylkplfgilaknqlengnrPlvv

HCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLE
.|| ||||.| |  .   .||.| ||  |.|. ....| ||...|.||..| ... .. || |
acsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyae
0046845 (Phosphotyrosine protein) phosphatases II 312-578 2.4e-96 317.7 In-house 3-282 (284) alignment 
Range on Protein: 312-578
Range on HMM: 3-282/284.0
DLEFERLTRDERHPT-QFKSAMLSCNAAKNRYANILPYERTRVALHMRPGE-VGSDYINASFIDGN-----HRLKAYIATQAPVPRTFEDFWRMLWEQES
. |||.|..   ... ... |.| .|  |||| .||||...|| |.. .|.  .|||||||..||      .. |..||||.|.| |.||||||.|||..
eeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnv

AVIVMLTREEEAGKLKCHRYWPSDG-SRLYDKILVELTEELTYSDYVLRQFSLTHTE-EKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQ-S
 ||||||...| |. ||..|||..| .  |... |.|..| ...||..| ..||... .. ||.|..|..|.||| | |.|   |.... .|...... .
rvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlp

GNTCITVHCSGGVGRTGVFCAVSILIERVKAEG---LIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLESFDLYAN
|.  | ||||.||||||.|.|. .|.|....||    .||...|..|| ||| |||| .||.|.| ...||| ..  ...
gggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltlle
subfamily_PTPRB_pd Subfamily PTPRB 312-571 8.8e-85 279.3 In-house 28-286 (293) alignment 
Range on Protein: 312-571
Range on HMM: 28-286/293.0
DLEFERLTRDERHpTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLT
  |.|.|   ... .. |.| |..|.||||| |||||. .|| |.   .| |||||||..|.|..  . .|||| |.| |..|||||.||..| .|||||
seeyeelkavgkd.qavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmlt

REEEAGKLKCHRYWPSD-GSRLYDKILVELTEELTYSDYVLRQFSLTHteEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQ-QQSGNTCITVH
.  | || ||..|||.|  . || .| |.|..| ...|.|.|......  ||..| |||.. | ||| | ||.   |.|.. .|.... ... .. |.||
qlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvh

CSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLE
|| ||||||.| |.  |..... | ..|.| .|..|| .|  .|||..|| | .......|.
CsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 313-574 9.3e-85 279.4 In-house 26-287 (305) alignment 
Range on Protein: 313-574
Range on HMM: 26-287/305.0
LEFERLTRDerhPTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTR
 ... |...   .....    . |.||||...| ...  |. |  .. .  |||||||..|| .| |.||..|.|.. | .||||...|    .|||||.
aqykslyee...eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltk

EEEAGKLKCHRYWPSDGSR--LYDKILVELTEELTYSDYVLRQFSLTH-TEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSGNTCITVH
  | || ||..|||   ..   .... |||..| |.|||. |.....   |.| || | |.| ||||| | |..   |..|| .|.| |... .. ..||
lveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVh

CSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLESFD
|| ||||||||.||.| .||.|.|. .|||. ...|| .|. ||||.||| |..  ..|.....|
CsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 313-576 1.1e-77 255.8 In-house 24-289 (290) alignment 
Range on Protein: 313-576
Range on HMM: 24-289/290.0
LEFERLTRDERHPTqFKSAMLSCNAAKNRYANILPYERTRVALHMRPGE--VGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVML
 .|..|   |.. |  . .. | |  .||.|||..|.  |. |.  .|.     .||||..|.| .  |.|||||.||..|  |||...|......||||
nqfkmldsgeseht.vtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivml

TREEEAGKLKCHRYWPSDGSRLYDKILVELTEELTYSDYVLRQFSLTHTEE-KSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSGNTCITVH
| . | || ||. |||. ... |... ..|..| |...|. |......... .....| |.| | |.. |  .   . . .| ...| | ..||| | ||
tniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvH

CSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLESFDLY
||..|||..||||. . |...| || ||||| ....| |.| .|||..||.. .. . .||.||. |
CSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 313-568 3.4e-75 248.2 In-house 2-253 (284) alignment 
Range on Protein: 313-568
Range on HMM: 2-253/284.0
LEFERLTRDERHPTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTr
 || |...     |. . | |  |  |||. .||......| |.   || .||||||||| |  | . ||||| | . | .|||||.||.... ||.|| 
vefrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.

eeeagKLKCHRYWPSDGSRLYDKILVELTEELTYSDYVLRQFSLTH-TEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQ-QSGNTCITVHC
     | || .||| ..   ...  |...     ..||.|.. |.. ..||  | .|||    ||| | |.... |. |. .|.. .. . ... | |||
.....kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhc

SGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQE
| |||||||. .. .|..|.| |  .||...|. || ||. .||   || |.|... |
sagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_PTPN3_pd Subfamily PTPN3 313-570 3.4e-67 221.3 In-house 19-276 (280) alignment 
Range on Protein: 313-570
Range on HMM: 19-276/280.0
LEFERLTRDERHpTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPgeVgsDYINASFID----GNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIV
 .||.| | ..   . . | .. |..|||| .||||. ||| |.  .  .  |||||....    ...  . ||||| |...| .|||.|.|||.| .||
aqfeqlyrkkpg.laisaarkpenlsknryrdilpydatrvklkese..t..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssliv

MLTREEEAGKLKCHRYWPSDGSR-LYDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQqSGNTCIT
|||   | |. |||.|||. . .  | .. |....| . . ||||.. |...|.| .| . |.| ..|||.|.|..   ..... .|.| .. . .. . 
mlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrs.gkeePvv

VHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEF-CYTTIQEYL
||||.|.|||||. .. . .  . |.  . . . |...| || ..|||..||.| | .... | 
vhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvye
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 314-574 1.1e-98 325.2 In-house 28-287 (319) alignment 
Range on Protein: 314-574
Range on HMM: 28-287/319.0
EFERLTRDERHptQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTRE
||. |   .    .|.||    |  |||| |||.|.||||.|   .|  |||||||||||| .. ...||||||.  |.||||||.||.|| ..||||. 
efkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltkl

EEAGKLKCHRYWPSDGSRLYDKILVELTEELTYSDYVLRQFSLTHTEEKS-SRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSGNTCITVHCSG
 | .|.|...|||.     | ...|.| ||   .||. |...| .  ..  .| | .|| |.||| . ||.. .|.||.....| .... .  |.|||| 
veklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsa

GVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLESFD
|||||| |..... .|||| ||..|||.||..||.||. |||...||.|.| .. |..|..|
GvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
DSPc_SM00195 314-570 1.1e-90 299.0 In-house 5-262 (263) alignment 
Range on Protein: 314-570
Range on HMM: 5-262/263.0
EFERLTRDERHPtQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTRE
|||.| . . .  ....|  . | .|||| |||||..||| |. .... |||||||..|.|... |.|||||.| | |.|||||| ||... .|||||.|
efekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmltee

EEAGKLKCHRYWPSD--GSRLYDKILVELTEELTYS-DYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSgNTCITVHC
|| || ||.||||..  |.  ..|| |.|.|. ... ...||...||..... .| |.|.|...|||.|.|.|   ...|. .|.|....| .. | |||
eengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhC

SGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
| ||||||.|....|.......|  .|.|..|..|| ||| ||||..|| |.|..| ||.
saGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 314-570 1.1e-90 299.0 In-house 5-262 (263) alignment 
Range on Protein: 314-570
Range on HMM: 5-262/263.0
EFERLTRDERHPtQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTRE
|||.| . . .  ....|  . | .|||| |||||..||| |. .... |||||||..|.|... |.|||||.| | |.|||||| ||... .|||||.|
efekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmltee

EEAGKLKCHRYWPSD--GSRLYDKILVELTEELTYS-DYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSgNTCITVHC
|| || ||.||||..  |.  ..|| |.|.|. ... ...||...||..... .| |.|.|...|||.|.|.|   ...|. .|.|....| .. | |||
eengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhC

SGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
| ||||||.|....|.......|  .|.|..|..|| ||| ||||..|| |.|..| ||.
saGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPN9_pd Subfamily PTPN9 314-570 1.3e-82 272.2 In-house 21-290 (297) alignment 
Range on Protein: 314-570
Range on HMM: 21-290/297.0
EFERLtRDERHPTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTRE
|.. . |.|    .|. ..| .|  ||||...| |..||| |  ....  ||||||.|.|| .. ||.|||| |...|..|||||.||||  |||| || 
eyaei.rnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrv

EEAGKLKCHRYWP--SDGSRLYDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEK------------WQQ
.| |.||| .|||  .. |  . .. |.  |  ...||. |.. ....... || |  || . ||| | |.|.  |.|.. .| .            |. 
vergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkg

QSGNTCITVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
.  .  | |||| |.|||| |... | ..|.. .| .||..||..|| ||  ..|| .|||||| .. || 
hpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 314-571 4.1e-78 257.3 In-house 20-277 (281) alignment 
Range on Protein: 314-571
Range on HMM: 20-277/281.0
EFERLTR-DERHPTQfkSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTR
|.| |.  . .....  ..    |  |||| ||  |. ||| ..    .  .|||||.|..| .  |.|||||.||| ....||.|.|||.  .|||.||
eyeklaaigvdntat..askadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtr

EEEAGKLKCHRYWPSDG-SRLYDKILVELTEELTYSDYVLRQFSLtHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSGNTCITVHCS
| |||||||||||| |  .  | .. |. |.| . . |. |.|.| ..|.  .| |.|.. | ||| | |..   |..   .|.| .... .. . .|||
eieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCs

GGVGRTGVFCAVSILIERVKAE-GLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLE
 ||||||.. |.  |...|.||   .|| ..|..|| .|  ||||  |||| | .. ..|.
aGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 315-571 2.3e-59 195.6 In-house 1-265 (270) alignment 
Range on Protein: 315-571
Range on HMM: 1-265/270.0
FERLTRDERHPTQFKSAmlSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDG-NHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTRE
|..|...| ..... .|    ... ||||.|||  .||| |.    .  . |||| .. | ... |.|||...|.| | ..||||.||...  |||.|  
fkeldkeetsesdlpea..argkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgl

EEAGKLKCHRYWPSDGSR----LYDKILVELTEELTYSDYVLRQFSLThTEEKSSRIVrQFQCTDWPDSGLPESGV------GLIDLIGQVEKWQQQSGN
|| |. || ||||..  .     . || |  ..|   . |.|..  |. .. .. |.|  |. ..||| | |..         |. .. .| .....  .
eEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle.ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldk

-TCITVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLE
 . . |||| ||||||.. |. | .. .. .. .|| . ...|| .|.|.||. .|||| | ...|| |
aePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_ptpA1_pd Subfamily ptpA1 317-530 5.3e-43 142.3 In-house 28-256 (418) alignment 
Range on Protein: 317-530
Range on HMM: 28-256/418.0
RLTRDERHPTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRlKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEA
||  .   |..        |..||||.|||| ..||| |.    . ||||||| .||| .  | .|.|| |.| |  |||||.||.   .||||.|| | 
rlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsresen

GKLKCHRYWPS-----------DGSRLYDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQ-----
 ..|| ||||            .|  ..    ||| | .   .  .    .  | |  .| . |.|   |||  .|.    . .|.  . . |.|     
crikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipss

SGNTCITVHCSGGVGRTGVFCAVSILIERV
  |  | |||| |||||| ||.  |.....
drnvpiivhcsagvgrtgtfctavimmkkl
0045098 (Phosphotyrosine protein) phosphatases II 320-571 7.5e-85 279.9 In-house 17-273 (278) alignment 
Range on Protein: 320-571
Range on HMM: 17-273/278.0
RDERHPTQFKSAMLSCNAAKNRYANILPYERTRVAlhmrpgevgsDYINASFIDGNhRlKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKL
.   .| ..  |.. .|..|||| .||||...||           ||||||.|||  . |..||||.| | |..||||||||. . ||||||...| |. 
lllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy.p.kkfIatqgPlpstvadfwrmlwelgitvivmltelvelgre

KCHRYWPSDGSRLYDKILVELTEELTYSDYVLRQFSLTHT----EEKSSRIVRQFQCTDWPDSGLPESG--VGLIDLIGQVEKWQQ------------QS
||..|||..||  |... |.|..| ...||.|| . .|..    |.  || |...... ||| | |..     ...|. .......            ..
kcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllld

GNTCITVHCSGGVGRTGVFCAVSILIERVkaEGLIDVFQTVQHLRLQRPA-MVQTKDQYEFCYTTIQEYLE
..... |||| ||||||...|. ...|..  || .|....|..|| |||  .||...||.|.|  ..|.|.
sggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_PTPN12_pd Subfamily PTPN12 320-571 8.1e-81 266.1 In-house 26-278 (290) alignment 
Range on Protein: 320-571
Range on HMM: 26-278/290.0
RDERHPTQfkSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKL
... ..|.  ..  . | .|||| .||||. .|| |.   .| |||||||.|| | .  ..|||.|.|.|.| .|||||.||..  ..||. || | || 
aekvyste..agekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkk

KCHRYWPSD-GSRL-YDKILVELTEELTYS-DYVLRQFSLTHTeeKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQqSGNTCITVHCSGGVGR
||.||||.  ...| .... |.|.|| . . |...|.. ...   | ||.|.||. |.||| | |.|   |..|| .|.. |. | .. . |||| ||||
kCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGr

TGVFCAVSILIERVKAEGL---IDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLE
||. .|. .  | .||| .   .|||. |..|| ||.|.||||.|||. | .. |...
tGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 320-483 1e-32 108.2 In-house 17-182 (297) alignment 
Range on Protein: 320-483
Range on HMM: 17-182/297.0
RDERHPTQFKSAMLSCNAAKNRYANILPYERTRVALhmRPGEVGSDYINASFI---DGNHRLKaYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEA
 ||... .| ||  .    |||| .|| .. ||| |  . .  ..||||| ..   | .. || || .| |. .| .|||....||.  ||||... .| 
ldeargesfssakrnsslrknryrdilatddtrvkl..lrviterdyinadyvvfpdeeadlk.yilaqGplsatvddfwtlvaeqdvrvivmvaklqed

GKLKCHRYWPS-DGSRL-YDKILVELTEELT--YSDYVLRQFSLTHTeeKSSRIVRQFQCTDWPDSGLPES
|. ||  |||| .. ||   ...||   . .  .   .| .. | .   . || ||  |   ||| |.|  
Grdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsd
subfamily_PTPN1_pd Subfamily PTPN1 321-568 1.3e-54 179.9 In-house 17-269 (290) alignment 
Range on Protein: 321-568
Range on HMM: 17-269/290.0
DERHPTQFKSAMLSCNAAKNRYANILPYERTRVALHMRpgEVgsDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLK
.| .  . ..| |  | ..||| .. ||. .|. |.    ..  ||||||... ..  . || || |.|.| . ||.|.|||.|  .||| .  | ...|
keasdfptreaklpenrnlnryrdvspydhsriklera..dn..dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqik

CHRYWPSDGS---RLYD--KILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSGNT-CITVHCSGGV
|..|||.. .    |..  |. |.| .| ..| |..|.. |.  . . .| . .|  | ||| |.|||   ..... .| .    | .     .||| |.
caqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGi

GRTGVFCAVSIL---IERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQE
||.| || |  .   ||. .    .|. ... .|| .|  ..||.|| .| |..| |
GrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 321-566 2.6e-20 67.7 In-house 4-255 (290) alignment 
Range on Protein: 321-566
Range on HMM: 4-255/290.0
DERHPTQFKSAMLSCNAAKNRYANILpYERTRVALHMRPGEVGSDYINASFIDGNHRLKaYIATQAPVPRT-------FEDFWRMLWEQESAVIVMLTRE
 |   . .|. ..  .. ..|... |  | |||.|.       .||| |...   . |.  |.||.|  ..        |.|| |  . ..  .|||   
kestavllktdyvkkhemdqRlevpL.veatrvvLkgygkrfnddyiHAnrvtcpnglr.liltqsPqekitekrnStiekfwwmakqEkvkqvVmlcef

EEAGK----LKCHRYWPS--DGSRLYDKILVELTEELTYSDYVLRQFSLTHTEEKSSRiVRQFQCTDWPDSGLPESGVGLIDLIGQVEkwqqqSGNTCIT
||  .      | .| |   ...  .. . |. ..  .  |   |.  ... .|.    |   .  .| ..  .|.   |..|| .|.       .| . 
eeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeeft.vtHsllkgWnklnvqedtktllsliqkvk.....asktpvi

VHCSGGVGRTGVFCAVSILIERVK-AEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTI
|||  |. |  .. |. .    .   .| . . . .. || ||  ..... .. |    |
vHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagi
subfamily_PTPRD_pd Subfamily PTPRD 323-575 3.1e-120 397.5 In-house 35-286 (564) alignment 
Range on Protein: 323-575
Range on HMM: 35-286/564.0
RHPTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCH
.. .....|  ..| ||||||||..|...|| |.. .|. |||||||||||| .. |||||||.|...|.||||||.|||.|..|||||. || || |||
gqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkch

RYWPSDGSRLYDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQqQSGNTCITVHCSGGVGRTGVFCA
.|||..|.  |... |.|.|| ...||..|.|.|.......|| ||||. |.|||.| |||. .|.||| .|.... .... .|.|||| ||||||.|..
kYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfiv

VSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLESFDL
.....||.|.|...|..|.|..|| ||.|||||..|| |....|.|.|.... 
idamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnt
subfamily_PTPN13_pd Subfamily PTPN13 323-572 4.2e-71 234.4 In-house 24-271 (273) alignment 
Range on Protein: 323-572
Range on HMM: 24-271/273.0
RHPTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGevgsdYINASFIDG--NHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLK
.   . ...    | .|||| |.|||..||| |    |     |||||.|    ..    |||.| |.| | .|||.|.|||.. ||.|.| | | ||.|
kpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvk

CHRYWPSDGS---RLYDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQqsGNTCITVHCSGGVGRT
||||||.  .    ..... ||| .   ....|.|.. ....| . || | ... ..||| | | | . |. .. .| . |.   .. | |||| |.||.
chrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaGiGrs

GVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLES
|.. .. .... .. .  .|| ..|..|| || ..||||||| |.| .| | |.|
Gtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlks
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 323-568 4.9e-70 230.9 In-house 38-277 (315) alignment 
Range on Protein: 323-568
Range on HMM: 38-277/315.0
RHPtqFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCH
 ||  .. |  . |  |||| ||..|...|| | .   . .|||.||.||||  . . |||.|.| . . .||||...|.. . |||||   |  | |. 
lhp..ldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkae

RYWPSDgSRLYDKILVELTEELTYSDYVLRQFSLTHTEekSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSGnTCITVHCSGGVGRTGVFCA
.||| .   .| || | . .|  ...|  | .| .  .    | | |.. | |||.|.|.. . |..|| .| .....|  . | |||| |||||| |..
kywpdk.kviyGkitvtrkseevnteytvrtlsvvfgd..nirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfit

VSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQE
.. ......|| .|||.. .. .| .|  |||. .||.| | .. |
ldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 323-376 2.1e-10 34.6 In-house 27-78 (244) alignment 
Range on Protein: 323-376
Range on HMM: 27-78/244.0
RHPTQfKSAMLSCNAAKNRYANILPYERTRVALHMRPGEvGSDYINASFIDGNH
|.  |  .|.||.||.|||| ||||.. ||| |     | |||||||..|.|..
reflq.tnavlsanatknryinilpfdetrvilssskke.gsdyinanyiqgsq
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 323-408 1.5e-09 31.9 In-house 24-114 (347) alignment 
Range on Protein: 323-408
Range on HMM: 24-114/347.0
RHPTQFKSAMLSCNAAKNRYANILPYERTRVALH-----MRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIV
  |..| |.    . .|||  .    . ||| |      . . .    ||||| |  .   | || || |.| |  |||.|.     . .|
yspskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvv
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 324-572 2.9e-66 218.8 In-house 36-290 (325) alignment 
Range on Protein: 324-572
Range on HMM: 36-290/325.0
HPTQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLtREEEAGKLKCHR
 .  .| ||.  | ||||. |.......|| |  .  .  |||||||..  . . . ..|.||| . | .|.||.. . ...|.|.|  | . || .|  
dgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvl.neldlgkdrcav

YWPSD--GSRLYDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQ-----QSGNTCITVHCSGGVGR
||| .   |. .  . |.|    ..|||| |.. .  ...  .| |.|||   |.| | ..    || ..  |.. ..       . | | |||| ||||
ywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGr

TGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLES
|||| ..  ....|  |  .|.|. |..|| .||.||.| ||| ..|... |.. |
tGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveayms
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 325-570 9.4e-18 58.8 In-house 36-279 (303) alignment 
Range on Protein: 325-570
Range on HMM: 36-279/303.0
PTQFKSAMLSCNAAKNRYANILPYERTRVALHmrpgevGSDYINASFIDGNHRLKAyIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRY
| .     .  |  |||.....  . ..| |        | || ||... . . || | || |.. |  |||.|. ||   ....|  . |  ||  .  
ppsvsknqfvknmdknrfvdvicldhskvkls......dssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsv

WPSDGSRL--YDKI-LV-ELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQctDWPDSGLPESG-VGLIDLIGQVEKWQQQSGNTCITVHCS-GGVGRTG
.| .   |   ..   | |. .      .||.  |..  . ||   | ...  .|| . .|  |   ..  | |..   ..  ..  ||. |  |.||.|
fprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhyk..awphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgrag

VFCAVSILIERVKAE-GLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
 |.        ...|   .|. . .. .|  |   ||   |. . || . |..
tfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv
subfamily_egg_pd Subfamily egg 326-567 5.8e-26 85.9 In-house 30-267 (307) alignment 
Range on Protein: 326-567
Range on HMM: 30-267/307.0
TQFKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAgkLKCHRYW
  .. |. . |  | |   .   . .||.|..| |    |.| |  ..|.  |  .| .|||.  | .|||||....|   |||||   |.   .|. ||
islttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyyw

PSDGSRLY----DKILVELTEELTYSDYVLRQFSLTH-TEEKSSRIVRQFQcTDWPDSGLPESGVGLIDLIGQVekwqqqSgnTCITVHCSGGVGRTGVF
|   |         . .|  .    .| ..|   |     ..  | .  .|  |.  |.   | . .. .. ..      |  . . |..  || .....
pkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwq.gdvnnssdvysplrvlrklrnl......s..kpvvvqdilGvskaatl

CAVSILIERVKAEGL--IDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQ
 |. | .  .    .    | ..|. |||.|.  |..  .| | |  . 
vaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_PTPRA_pd Subfamily PTPRA 328-570 2.9e-94 310.7 In-house 50-295 (330) alignment 
Range on Protein: 328-570
Range on HMM: 50-295/330.0
FKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPS
.. |    |  |||. |||||. .|| | .. |.  ||||||||||| .. . .||.| |  .| ||||||.|||.|| |||||  .|  . ||..|||.
lelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPd

DGSRLYDKILVELTEELTYSDYVLRQFSLT----HTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSGNtCITVHCSGGVGRTGVFCAV
.|.  | .| ||. .|    || .|.| ..    .|.||.||.||||  | ||| |.|  ..|...|. .|.| .|||..  |.|||| |||||| |...
eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivl

SILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
. ..||||||...|||..|..|||||| ||||. ||||.| ...|| 
davlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
0040439 (Phosphotyrosine protein) phosphatases II 328-570 4.1e-87 287.1 In-house 3-246 (249) alignment 
Range on Protein: 328-570
Range on HMM: 3-246/249.0
FKSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPS
.. |.| .|  |||| .||||...|| |.  ||  .|||||||.||| .. ...||||.| | |.|||||||||. . ||||||...| |. ||..|||.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

DGSRLYDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQS-GNTCITVHCSGGVGRTGVFCAVSIL
.||  |... |.|... ...||..|.. ||......|| |...|.||||| |.|.|   |.|.| .|.|....   .... ||||.||||||.|.|  ..
ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm

IERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
.|... |. .|....|..|| ||| .||. .||.|.|  ..|.|
leqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0042113 (Phosphotyrosine protein) phosphatases II 329-571 5.4e-87 286.5 In-house 2-244 (245) alignment 
Range on Protein: 329-571
Range on HMM: 2-244/245.0
KSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSD
..|.| .|  |||| .||||..||| |   .|. .|||||||..|| .. . .||||.| | |.|||||||||. . .|||||.||| |. ||..|||..
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

GSRLYDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSGNTCITVHCSGGVGRTGVFCAVSILIE
.|  |... |.|..| ...||..|....|.. .. || |.......||| | |..   |.|..  |.|......|. . ||||.||||||.|.|. ...|
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

RVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLE
....|. ......|..|| ||| .||| .||.|.|  ..|.|.
qlekelgvsleeavkelrsqRpgavqtpsqyrflyeallellk
subfamily_PTPRK_pd Subfamily PTPRK 329-568 4.4e-80 263.8 In-house 36-275 (314) alignment 
Range on Protein: 329-568
Range on HMM: 36-275/314.0
KSAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSD
 .|    | .|||. .||.|.|.|| |.   |.  ||||||..||. .| .|.|.|| |.. | .||||.......| |||||   | |..|| .||| |
daakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed

GSRlYDKILVELTEELTYSDYVLRQFSLTH--TEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQsGNTCITVHCSGGVGRTGVFCAVSIL
..  |..| ||| |  . ...| | |....     .  |.||||| . ||| . | |  ||..|. .|.|.|.. ..  | |||| | ||||.|.|..|.
tev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidiv

IERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQE
.. .. ||..|||..|. || ... ||.|..|| |.|  | |
ldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
0037934 (Phosphotyrosine protein) phosphatases II 329-570 9.2e-77 253.1 In-house 3-242 (243) alignment 
Range on Protein: 329-570
Range on HMM: 3-242/243.0
KSAMLSCNAAKNRYANILPYERTRVALhmrPGevgSDYINASFIDGNHRlkaYIATQAPVPRTFED----FWRMLWEQESAVIVMLTREEEAGKLKCHRY
. |.| .|  |||| .||||...|| |   .|   ||||||..|..  |   .||||.| | |.||    |||||||. . ||||||...| |..||..|
siallpenlsknrysdilpydhsrvkl...eg...sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPsdGSRLYDKILVELTEELTYSDYVLRQFSLTHTE-EKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQ-------SGNTCITVHCSGGVGR
||  |.  |... |.|..| ...||..| ..|.... .. .| |...... ||| | |.|   |.|.. .| .....       ...  . ||||.||||
wp..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

TGVFCAVSILIERVkaeGlIDVFQTVQHLRLQRPA-MVQTKDQYEFCYTTIQEYL
||...|  ......   | .|....|..|| |||  .||| .||.|.|  ..|.|
tGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 329-571 1.8e-70 232.2 In-house 21-269 (274) alignment 
Range on Protein: 329-571
Range on HMM: 21-269/274.0
KSAMLSCNAAKNRYANILPYERTRVALHMRPGEVG-SDYINASFIDGNH-RLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWP
.  ... .. |||| .||| |..|| |. . .|   |.|||| .| | . . |||.||| |.| | .|||||....|. ||||||. .|| . ||..|.|
eeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfP

SDGS----RLYDKILVELTEELTYSDYVLRQFSLTHTEEksSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSGNT--CITVHCSGGVGRTGVF
 . .      |... .. .. ..  || .|...| ..|.  .| |  .  |||||   |..   |.||. .||. .... .    . |||| |.||||.|
daedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcf

CAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLE
 |.|| . ....|. .||...| .|||.|  ||||..|||. . .. .||.
iaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
0049772 (Phosphotyrosine protein) phosphatases II 329-572 3.2e-43 144.0 In-house 39-282 (314) alignment 
Range on Protein: 329-572
Range on HMM: 39-282/314.0
KSAMLSCNAAKNRYANILPYErTRVALHMRPGEvGSDYINASFIDGNhrlKAYIATQAPVPRTFEDF----------WRML--WEQESAVIVM-------
. | | .|  |||| .|||.. .|| |.  |.. ||||||||..||    ...||||.| . |..||          |||   ... . .|||       
lvadlflnrdknryldilpad.nrvilpglpvs.gsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevla

--------------LTREEEAGklkcHRYWPSDGSRLYdkilvelteeltysdY-------VlrqfslthteeksSRIVRQFQCTDWPDSGLPeSGVGLI
              |..  . |      ....|   |                        .             .| . .. ....|| . | .   . 
delsrLdaAlgKtpllildgng....neptaadlellk...............eelydpelf.............erlgikylripvpDgsap.lledfd

DLIGQVEKWqqqSGNTCITVHCSGGVGRTGVFCAVSILIERVkaeGLiDVFQTVQHLRLQRP-----AMVQTKDQYEFCYTTIQEYLES
...  .|..   . .... |||..|.||||.|... .|. .    |. .. ......||.||      .... .||||..  ..|||. 
eflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkf
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 330-375 8.3e-08 26.0 In-house 41-86 (440) alignment 
Range on Protein: 330-375
Range on HMM: 41-86/440.0
SAMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGN
 | |  |  |||| ||| |...|| |.   |   |||||||.|.| 
iaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 331-569 4.4e-34 112.4 In-house 49-282 (290) alignment 
Range on Protein: 331-569
Range on HMM: 49-282/290.0
AMLSCNA--AKNRYANILPYERTRVALHmrPGEVGsDYINASFIDGNHrlKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSD
 ..  |.   |||| ..   ..||| |.   |  | ||. | ...| .    .| || ..  |  |.|||. ... |.||||    | || ||..|.|  
kifdkntefkknrykdvvcndktrvilk..dGydG.dyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypek

-GSRL-YDKILVELTEELTYSD-YVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKwqqQSGntCITVHCSGGVGRTGVFCAVSI
 |  | . .| |  .|| .  .  ... .|. . ..  . ... ..   |||  .. | . |. ..  . |    ||   ..|||| |.|||| | |. .
eGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk...asG..pvvvhcsaGiGrtGtfvaiev

LIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEY
 .. .     .|. ..|. ||  | . ||   ||      . ..
glqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 331-416 2e-10 33.8 In-house 22-80 (169) alignment 
Range on Protein: 331-416
Range on HMM: 22-80/169.0
AMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINAsfidgnhrlkayiatqapvprtfedfwRMLWEQESAVIVMLTREEEA
| |.|| .||| |  |   .||| |.    ..|||||||                           ||.|| ...|||.|   .. 
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddk
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 331-416 2.4e-10 33.5 In-house 21-79 (169) alignment 
Range on Protein: 331-416
Range on HMM: 21-79/169.0
AMLSCNAAKNRYANILPYERTRVALHMRPGEVGSDYINAsfidgnhrlkayiatqapvprtfedfwRMLWEQESAVIVMLTREEEA
| |.|| .||| |  |   .||| |.    ..|||||||                           ||.|| ...|||.|   .. 
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddk
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 333-570 4.8e-32 106.0 In-house 32-270 (285) alignment 
Range on Protein: 333-570
Range on HMM: 32-270/285.0
LSCNAAKNRYANILPYERTRVALHMRpgevGSDYINASFIDGNH-RLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSDGSR
  .|   ||||..   | ||| |. .      ||| ||..        .||.|| |.| |. |||.|..... | ..||    | |  ||  |.|     
yeanpdlnryadvrcieetrvvlknh....drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

L-----YDKILVELTEElTYSDYVLRQFSLTHTEEKSSRI--VRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQsgNTCITVHCSGGVGRTGVFCAVS
.     |.  | |  || . .  .|  .... ||. ||    . . |   |||   ||    .|.|   |.| . .  .. | |||| |||||  |  . 
vvkfgkyeitlteckee.aiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk..ekpicvhcsagvgrtatfvgid

ILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
    |.  .  |.... |. .|  |   ||.. |. | |  . ||.
yatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 333-573 7.7e-31 101.9 In-house 45-290 (305) alignment 
Range on Protein: 333-573
Range on HMM: 45-290/305.0
LSCNAAKNRYANILPYERTRVALHmrpGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSDGSRL
 . .| |||| ..   .. || |.   |    .|| | ..      | .| ||||. .|  ||| | ...    | ||    | |  ||. |..|.    
eaqeagknrykdvgcldnnrvkle...gpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdv

------YDKILVELTEELTYSDYVLRQFSLTHT------EEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVekwQQQSGntCITVHCSGGVGRTGVF
       .|| | .    |..     .  .|.|        ...| | ..   |||| |.| . . ...|. .    .   |   |.|||| |.||||  
lefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka...rpskg..pivvhcsagigrtgsv

CAVSILIERVKAEGLIDVF-QTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLESF
  .  ..... |   |.   . .|..| ||   .|| .|| | .  | .|..  
vmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkk
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 333-385 2.8e-12 40.6 In-house 45-94 (95) alignment 
Range on Protein: 333-385
Range on HMM: 45-94/95.0
LSCNAAKNRYANILPYERTRVALHMRpgeVGSDYINASFIDGNHRLKAYIATQ
  .|  |||. ||.||. |||.|  .     |||||| |.||  | ..|||.|
seanipknrflnifpydatrvvlttk...rdsdyinacfvdgyarkncyiaaq
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 334-574 5.1e-74 244.1 In-house 49-288 (297) alignment 
Range on Protein: 334-574
Range on HMM: 49-288/297.0
SCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRlkAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKlKCHRYWPSDGSRLY
  |  |.||.|||||.. || |...  .  |||.||||. ||.    .|.|| | . | .|||.|..... ..||||. ..|  | || |||. .|.  .
kvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttf

DKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPE--SGVGLIDLIGQVEKWQQQSGNTCITVHCSGGVGRTGVFCAVSILIERVK
 .. |.|.     . .. |....|. . |. |.|.|.| ..|||   ..  |   |..|| .|.|  .|  .. . |||. |||||||....   . ..|
GdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeak

AEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLESFD
 |  .|.|..|..|| .|| .||||.||.| | .. |.| | |
rekevdifglvkklrqerpylvqtkeqykfvyvavleallsed
subfamily_CG7180_pd Subfamily CG7180 334-570 1.2e-64 212.8 In-house 40-290 (296) alignment 
Range on Protein: 334-570
Range on HMM: 40-290/296.0
SCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKlKCHRYWPSDGSRLY
. |  |||. ...||. .|| |.   ||  ||||||...|.  . |.|| |.||. .| ..|||.....|.  .|.||.. .  | ... ||| ..   |
kenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqy

DKILVELTEELTYSDYVLRQFSLTHT----------EEKSSRIVRQFQCTDWPD-SGLPESGVGLIDLIGQVEKWQQQS----GNTCITVHCSGGVGRTG
 .|.||..|| .|.. . |.| ||..          ..   |||..|| | |.    .| |  .||.|. .|..|...      .  . |..| |..|.|
geifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsG

VFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
|..|. . .| |. |. .|||. |. || .|| .|.....| ..| ...|..
vylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 334-566 7.2e-55 180.7 In-house 6-237 (239) alignment 
Range on Protein: 334-566
Range on HMM: 6-237/239.0
SCNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFI-DGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSDGSRl
  | ||||||||. |...|| |     .  |||||||.. | .   |||||||  |  .  |||||.|..  .||||||   |  | |||.|||   |. 
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk.

YDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKwQQQSGNTCITVHCSGGVGRTGVFCAVSILIERVKA
| .. | | .   ..||..| | ...  .   | | |.. | ||| |.|.    .. |  .. | .   |     .||| |||||| |  .  .. . | 
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakk

EGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTI
.  .|.|. |. .| .|| |||| .|| | . ..
qktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 334-566 5.5e-36 118.7 In-house 35-265 (281) alignment 
Range on Protein: 334-566
Range on HMM: 35-265/281.0
SCNAAKNRYANILPYERTRVALHM-RPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSDG--S
  |  ||||.||   . .|| |..  | .  .||| | .|      . || || |   |  |||||.|..... |||| .  |. . ||  |.| .    
pvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcc

RLYDKILVELTEELTYSDYVLRQFSLTHteEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVekwQQQSgnTCITVHCSGGVGRTGVFCAVSILIERV
  .||. |.  .       |  .. |..  |  .|.. ..   .|||  .|||   .. .. ..   . .|  |   .||| ||||.| . || | .. .
lqfdklsvsyedstvnkslvttrlnlsy..egetrlithwlwkewpdwqvpessevmlkilrki...rars..tppvihcsagvgrsgtlmaveialqsi

KAE-GLIDVFQTVQHLRLQ-RPAMVQTKDQYEFCYTTI
..   | |. | | |||.  | | ||| .|| . .  .
hshftlpdikqivshlrvtgraasvqtlqqymliwkvl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 334-570 1e-30 101.4 In-house 53-289 (305) alignment 
Range on Protein: 334-570
Range on HMM: 53-289/305.0
SCNAAKNRYANILPYERTRVALHmRPGevGSDYINASFIDGNH-RLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSD-GSR
  . .||||...   ... | |. .|    |||| | ..       | .|..| |. .| ..|| |. ..    |||| .  | ||||| .|||   | .
diaitknryqdvpcqdqsavkld.kps..psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgek

--LYDKILVELTEELTY----SDYVLRQFSLTHTEEKsSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVekwqqQSGNTCITVHCSGGVGRTGVFCAVSI
  |   |.||           ..  .  . ||.. .. .  ||..| |.||| |.|   .  ..|.  .     .  .  | |||| |.||||   |.  
lelksgivvenvsgskpmerdaeiqitllnltysgdq.kmsvrhlqwtewpdrgvppckltslellsai.....rgskvpivvhcsagigrtgtivaiey

LIERVKAEG-LIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
..|..  .     . . |. || ||   .|.  || | .  . .|.
ilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 335-577 4.2e-88 289.8 In-house 8-249 (250) alignment 
Range on Protein: 335-577
Range on HMM: 8-249/250.0
CNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLkCHRYWPSDGSRLYD
 |  |||||.|.... .|| |.   |.  ||||||||..| .  ||.||||.|...|.||||||..|..|..|||||  .| .|  .|.||| .... | 
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyG

KILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSGNTCITVHCSGGVGRTGVFCAVSILIERVKAEG
...|.| .. ...||. |.. |........|||||.. . ||| | ||     ..|. .|.. |||.||. . |.|| ||||.| |.|.. ..||.| | 
dvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkek

LIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLESFDLYA
 .|||. .. || .|| .|....|| |.|. |...|.|.. ||
vvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedya
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 335-566 7.3e-55 180.7 In-house 6-236 (239) alignment 
Range on Protein: 335-566
Range on HMM: 6-236/239.0
CNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFI-DGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSDGSRlY
 | ||||||||. |...|| |     .  |||||||.. | .   |||||||  |  .  |||||.|..  .||||||   |  | |||.|||   |. |
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk.y

DKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKwQQQSGNTCITVHCSGGVGRTGVFCAVSILIERVKAE
 .. | | .   ..||..| | ...  .   | | |.. | ||| |.|.    .. |  .. | .   |     .||| |||||| |  .  .. . | .
cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqakkq

GLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTI
  .|.|. |. .| .|| |||| .|| | . ..
ktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 335-570 2.1e-51 169.8 In-house 47-279 (439) alignment 
Range on Protein: 335-570
Range on HMM: 47-279/439.0
CNAAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKlkchrYWPSDGSRLYD
 . .|||| .. ... |||.|.  ||   | |||| .|.| .  | |||||.|   | .||||...|. .. |||||   |. |     |||||.   | 
ydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcyg

KILVELTEELTYSDYVLRQFSLTHTEE--KSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSGNTCITVHCSGGVGRTGVFCAVSILIERVKA
 | |    ..   .||.| | .    .  .  | | ||. . |||  .|     ..|..  ..  ...     . |||| ||||||   |. | .|..|.
diavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlkl

EGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
|  .|.   |. || ||  |||.  || | | .. | .
enkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 335-570 2.8e-28 93.8 In-house 42-271 (288) alignment 
Range on Protein: 335-570
Range on HMM: 42-271/288.0
CNAAKNRYANILPYERTRVALHmrpgEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSD-GSRL-
 |....|| |.   . ||| |.    .    ||.|  .  ..  .  | .|||.  | | .|.|| |..   ||||..  | || |   |.||  | .  
anptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

YDKILVELTEELTYSDYVLRQFSLTHTEE-KSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVekwqqQSGNTCITVHCSGGVGRTGVFCAVSILIERVK
. ..     .. .  | ...   |  ..| . . ||..    .|.| |.||. .  . |.  .     .| .  | ||.| |||||| .  . | .| ..
igrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililialeslr

AEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
 .  . . . ...|| .|   .||. || . .  . |.|
lddflgirsllaklreerfkaiqtemqylyvhrcvleel
Y_phosphatase Protein-tyrosine phosphatase 336-568 1.1e-83 275.6 Pfam-A 1-235 (235) alignment 
Range on Protein: 336-568
Range on HMM: 1-235/235.0
NAAKNRYANILPYERTRVALHMRPGEvgSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWP--SDGSRLY
|  |||| .||||..||| |. ..|.  ||||||....| .. |..||||.|.. |.||||||.|.... ||||||..|| |. ||..|||  ...|  |
nkkknRykdilpydktrvklkgsegp..sdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

DKILVELT-EEL-TYSDYVLRQFSLTHTEEKS-SRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQqQSGNTCITVHCSGGVGRTGVFCAVSILIERV
..| |||. .|    ..|.||...|....|.| .|.|.|...|.|||.|.|||  .|.||| .|||.. .. .. ..|||| ||||||.|.|..||.|..
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

KAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQE
.||. .||.|.|..|| ||| |||. .||.|.| .|.|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 336-568 1.1e-83 275.6 In-house 1-235 (235) alignment 
Range on Protein: 336-568
Range on HMM: 1-235/235.0
NAAKNRYANILPYERTRVALHMRPGEvgSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWP--SDGSRLY
|  |||| .||||..||| |. ..|.  ||||||....| .. |..||||.|.. |.||||||.|.... ||||||..|| |. ||..|||  ...|  |
nkkknRykdilpydktrvklkgsegp..sdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

DKILVELT-EEL-TYSDYVLRQFSLTHTEEKS-SRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQqQSGNTCITVHCSGGVGRTGVFCAVSILIERV
..| |||. .|    ..|.||...|....|.| .|.|.|...|.|||.|.|||  .|.||| .|||.. .. .. ..|||| ||||||.|.|..||.|..
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

KAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQE
.||. .||.|.|..|| ||| |||. .||.|.| .|.|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 336-568 2.8e-55 182.1 In-house 3-237 (237) alignment 
Range on Protein: 336-568
Range on HMM: 3-237/237.0
NAAKNRYANILPYERTRVALHMRPGEvgSDYINASFIDGN-HRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPS-DGSRLY
| .||||.||  |. .|| |.   ..  ||||||....|     | |||.| |.  . .|||.|.|..  .||||||   |  .||||.|||| |  . |
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

DKILVELTEELTYSDYVLRQFSLTH-TEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQ-SGNTCITVHCSGGVGRTGVFCAVSILIERVK
 .. | |. .  .||| .| . |.. .. |  |.. |.| | ||| |.|.    |. .  .. .  .  |  .   .||| ||||||.|  .  .. . |
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

AEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQE
 . ..|... |. .  .|| ..|||||| | . || |
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
0041856 (Phosphotyrosine protein) phosphatases II 336-571 1.5e-50 166.6 In-house 1-172 (182) alignment 
Range on Protein: 336-571
Range on HMM: 1-172/182.0
NAAKNRYANILPYERTRvalhmrpgevGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTreeeagklkCHRYWPsdgsrlydk
|  |||| .||||...|          ..|||||....|... . .||||.| ..|..||.|||.|.   .||.||         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

ilvelteeltysdyvlrqfslthteEKSSRIVRQFQCTDWPDSGLPEsGVGLIDLIGQVEKwqqqsGNTCITVHCSGGVGRTGVFCAVSILIERvkaeGl
                         |.  | . |.... ||| | |.    |.|.| .|..      . .. ||||.||||||...|  .....    | 
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.

IDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLE
......|...| .|| ||.| .|| |..  . |.|.
vsleeavklvrsrRpgmvitpnqyfflqlallelll
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 336-562 6.2e-26 85.7 In-house 52-282 (310) alignment 
Range on Protein: 336-562
Range on HMM: 52-282/310.0
NAAKNRYANILPYERTRVALHMRPGEVgSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSDGS-RLYD
.  ||||....  . .|| |..       ||| | ..  |.  ...| .| |.  |  |||||.... .  |..| .  | |. ||  |||| |    | 
ymhknrysdvvcldtsrvklkidksry.edyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetyg

KILVE----LTEELTYSDYVLRQFS-LTHTEEKSSR----IVRQFQCTDWPDSGLPESGVGLidlIGQVEKWQQQSGnTCItVHCSGGVGRTGVFCAVSI
 | |      .||.   .  .         .|. .      |   .  .||| |.|.  .     . |    | . |  |. |||| |..|..| .|. .
cirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekcht...vpqrllaqvrhg.pcv.vhcsagkdrlyvvvalkl

LIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFC
 |....    .|. . . .|. .|   .||. || . 
kidkldrglkvdaeevktellksraiciqtelqylii
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 336-416 1.6e-08 28.4 In-house 34-113 (332) alignment 
Range on Protein: 336-416
Range on HMM: 34-113/332.0
NAAKNRYANILPYERTRVALHmrPGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFE-DFWRMLWEQESAVIVMLTREEEA
|   ||   .  ....|| |   | .   |. |||..||  .  ||| .|||.    |  ||||. |.. ..|...   .| 
nmdmnriphlycfdhsrvela..pqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidek
subfamily_CG42327_pd Subfamily CG42327 337-495 6.2e-29 95.7 In-house 29-191 (319) alignment 
Range on Protein: 337-495
Range on HMM: 29-191/319.0
AAKNRYANILPYERTRVALHMRPGEVGSDYINASFIDGNHRL-KAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPS----DGSR
  |.|..|..|   ||| |.  . .  . |..||.. | .     |||.|..   .  ||||..||| | ||| ||   | |  .| .|.|.    |. .
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnts

LYDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCtDWPDSGLPESGVGLIDLIGQVE
|| .||| | .  .   |..  . | . ... || .  .   .|.....| .   || .. .|.
lyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevr
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 337-442 7.1e-27 89.0 In-house 48-164 (350) alignment 
Range on Protein: 337-442
Range on HMM: 48-164/350.0
AAKNRYANILPYERTRVALH--------MRPGEVGSDYINASFIDGN----HRLK--AYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCH
 ||||| ||||||..|| |.        ..    ..|||||...  .    .      |||||||.|.|..||.... . .  ||..|| . | .  ||.
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

RYWPSDGsrlYDKILVELTE
|||.  .   ||.| | |..
rYWqegs...ydditvklas
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 337-447 5.5e-17 56.1 In-house 49-172 (349) alignment 
Range on Protein: 337-447
Range on HMM: 49-172/349.0
AAKNRYANILPYERTRVALHMRP--G------------EVGSDYINASFIDGNH--RLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLK
 ||||| .||||| .|| |.  .                .  ||||| ..   .    | |||||||.| | .||....  ..  ... |. ..| .  |
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

CHRYWPSdGSrlYDKILVELTEELTYS
|..||   .|  |. | | | .   |.
cdiywqe.ls..ysnitvklqnsslyi
subfamily_eak_pd Subfamily eak 337-481 2.8e-12 40.7 In-house 53-195 (332) alignment 
Range on Protein: 337-481
Range on HMM: 53-195/332.0
AAKNrYANILPYERTRVALHMRPgEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSDG--SRLYD
  .|   .|.||.|  | |          ||||| .. ..  . || | ..       ||.|. || |  ||.|  . | .  |  .|.| ..     . 
vnrn.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfG

KILVELTEELTYSDYVLRQFSLTHTEEKssRIVRQFQCTDWPDSGLP
.. ||  | .  . .  |.. |.  .|     |  ..   | .  ||
ildverkefvkrniletrllelskGnet..hrvlhykvfGwtettlp
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 339-559 1.1e-30 101.4 In-house 53-270 (301) alignment 
Range on Protein: 339-559
Range on HMM: 53-270/301.0
KNRYANIlPYE-RTRVALhMRPGEVGsdYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSDGSRLYD---
|.|| .. | .  | | . .  |.     | | .|. . . . .||||.|.. | |||| ||   .   ||||... |  . ||. | |.. |.  |   
khryptv.PckPstavev.ivdGkrv..PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr

-KILVELTEELTYSDYVLRQFSLTHTEEK-SSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKwqqqsGNTCITVHCSGGVGRTGVFCAVSILIERVKA
 || .. .| .   . . |.. .. . .| ..| |  .| ..|.| |.|.| . | ||.  | |      .  | |||| |.||.  | .  .|  .|.|
fkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk.....sekPivvhcsaGiGrsvafigteylarevea

EGLIDVFQTVQHLRLQRPAMVQTKDQY
.  |.. ....||| .|   |||. | 
dptieltealkhlrehrwngvqtnsql
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 339-577 5.9e-20 66.2 In-house 46-283 (312) alignment 
Range on Protein: 339-577
Range on HMM: 46-283/312.0
KNRYANILPYERTRVALHmrpGEvGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPS-------DGSR
 ||| ||  ..| | .|    |.    || | |.    . . ...||.|.  |   ||..     |. |..|.   | |  || .|          .  |
lnrypniqcwdrgrftla...gd.enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhr

LYDKILVELTEELTYSDYVLRQ-FSL-THTEEKSSRiVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQqsgntCITVHCSGGVGRTGVFCAVSILIER
.| .   |.       | .  . . .  ..  . |. . ..| . ||| |.|.|      |.  | | ..      .  ||| |||||| .. .  .|  
vyteycteieiggkskdkithrvlkvvvkatgqesk.lnhyqwaswpdhgmpdscdtalrllsavkkdkk.....pviahcsagvgrtgtlaliesmiaa

VKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLESFDLYA
..     .| ..   || .|   |..  || ..  .. |.| |  || 
lrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglyk
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 346-479 8.5e-12 39.5 In-house 3-125 (130) alignment 
Range on Protein: 346-479
Range on HMM: 3-125/130.0
LPYERTRVAlhmrpgevGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAgklkcHRYWPSDGS-RLY-DKILVELTEE
|..| .|.         | .||||||.    | . |. ||.|.  |  |||.|. |.   |.|.|   ||        |||       | ..|.| ||. 
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdr

LTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSG
  .      ..   .   .| . .  || ..||  |
defknikasnleiesdlneshqaltmfqisnwpsdg
0044763 (Phosphotyrosine protein) phosphatases II 347-569 1.1e-38 128.0 In-house 1-170 (178) alignment 
Range on Protein: 347-569
Range on HMM: 1-170/178.0
PYERTRVALHMRPGEVGSDYINASFIDGNhrlkAYIATQAPvprtfEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSDGSrlydkilvelteelty
|..|||| |....|. .|||||||.|...     |.... |     .|....|.|.   .||.|| | | |.|||..|||.. .                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

sdyvlrqfslthteekssrivRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSGnTCITVHCSGGVGRTGVFCAVSILIERvkaeGLiDVFQTVQHLR
                      |.... .||.| |..   . ...  .|......|  .. |||| ||||.|...|  .....    || .... ....|
.....................iqylhipipDhgvpdllehflefvefieealdekg.gpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvr

LQRPaMVQTKDQYEFCYTTIQEY
 .|| .|.. .|....|   ...
erRp.ivpnpgqlrqLyefelrl
0046846 (Phosphotyrosine protein) phosphatases II 356-572 3.4e-45 149.2 In-house 4-175 (176) alignment 
Range on Protein: 356-572
Range on HMM: 4-175/176.0
HMRPGEVGSDYINASFIDGNHrlkaYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSDGSRLYdkilvelteeltysdyvlrqfs
...  . ..|||||..|.|..    .||||.|.|||..||..||.|.   ..|.|| | | |.|||..|||   .  .                      
rllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi......................

lthteekssrivrQFQCTDWPDSGLPESgVGLIDLIGQVEKWQQQSgnTCITVHCSGGVGRTGVFCAVSilieRVKAEGLIDVFQTVQHLRLQRP-AMVQ
             |.....||| | |..   |..|. ........    .. ||||.|.||||...|       .. |  ..|.......| |||  .||
.............qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavq

TKDQYEFCYTTIQEYLES
| .||.|.|  ....|..
tpeQyrflyefellllkk
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 359-479 1.3e-13 45.2 In-house 117-234 (244) alignment 
Range on Protein: 359-479
Range on HMM: 117-234/244.0
PGEVGSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAgklkcHRYWP-SDGSRLYD-KILVELTEELTYSDYVLRQFSL
 | .|  ||||||.    |   || || |.  |  |||.|. |.   |.|.|   ||        ||| |.    |.  | | ||.   . .    .. .
kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdseplewyeeditvtltdrdefknikasnlei

THTEEKSSRIVRQFQCTDWPDSG
    ..| . .  || ..||  |
esdmneshqaltmfqisnwpsdg
0036282 (Phosphotyrosine protein) phosphatases II 363-563 3.5e-51 168.7 In-house 1-163 (174) alignment 
Range on Protein: 363-563
Range on HMM: 1-163/174.0
GSDYINASFIDGNHRLKAYIATQAPVPrtfedFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSdgsrlydkilvelteeltysdyvlrqfslthTEEK
||||||||..|...... .||.|.| .     ||.||.|. . ..|||..|.| |. ||..|||.                               . | 
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lred

SSRIVRQFQCTDWPDSGLPESGVgLIDLIGQVEKWQQQSGNTCITVHCSGGVGRTGVFCAVSILIERVKaEGLIDVFQTVQHLRLQRPAMVQTKDQYEFC
 .| . |.... ||| | |.. . |.... .||........ .. ||||.||||||...|  ... . . |.|.|....|. |||||| |||| .||.|.
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

Y
|
y
0043147 (Phosphotyrosine protein) phosphatases II 363-563 7.7e-46 151.3 In-house 4-154 (172) alignment 
Range on Protein: 363-563
Range on HMM: 4-154/172.0
GSDYINASFIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREeeagklkchrywpsdgsrlydkilvelteeltysdyvlrqfslTHTEEK
||||||||..|...  . .||||.| ..|..||||||.|.   .||.||..                                           ... |.
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpel

SSRIVRQFQCTDWPDSGLPeSGVGLIDLIGQVEKWQQQSGNTCITVHCSGGVGRTGVFCAVSILIervkaEGLiDVFQTVQHLRLQRPAMVQTKDQYEFC
 .| . |.... ||| | | .   |.... ........| . .. ||||.||||||...|  ...     .|| .....|...| .|| .||...|| |.
lerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl.sleeavalvrekRpgavqnpsqyrfl

Y
|
y
0051429 (Phosphotyrosine protein) phosphatases II 364-572 5.9e-53 175.5 In-house 4-227 (272) alignment 
Range on Protein: 364-572
Range on HMM: 4-227/272.0
SDYINASFIDGNHR---LKAYIATQAPVPRTFEDFWRMlWEQESAVIVMLTREEEAGKLKCHRYWP------------SDGSRLYDKILVELTEELTYSD
|.||||....|..|    ........| | | .||||. .|.   .||.|..||| |.|||.||||            |. . || .. | |..| ...|
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

YVLRQFSLTHT-EEKSSRIVRQFQCTDWPDSGLPESGvgLIDLIGQVEKwqqqsgNTCITVHCSGGVGRTGVFCAVSILIERVKAEGLID--------VF
|.|| . ||..   . .| |.....||||| | |..   |..|. .. .      .  . ||||.|..|||...|. .|...| .|  .|        ..
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

QTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLES
..|..|| |||..||| .||.|.|  ..|.|.|
eaveelraqrpgavqteeqylflyeallellrs
0051082 (Phosphotyrosine protein) phosphatases II 364-566 3.9e-37 122.5 In-house 3-149 (151) alignment 
Range on Protein: 364-566
Range on HMM: 3-149/151.0
SDYINASFIDGNhrlkaYIATQAPVPrtfeDFWRMLWEQESAVIVMLTREEEAGklKCHRYWPSDGsrlydkilvelteeltysdyvlrqfslthteeks
|||||.|...|.     ......| .    ||...|.|.   .||.|. ||| |  .|..|.|. |                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

sRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKwqqqSGNTCITVHCSGGVGRTGVFCAVSILIERvkaeglIDVFQTVQHLRLQRPAMVQTKDQYEFCY
 . |......|||| |||.|   ..... ....     .| .. ||||.|.||||...|. .....      ..........||.|| .||...|. |..
.ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

TTI
  .
fal
0049260 (Phosphotyrosine protein) phosphatases II 371-563 6.4e-41 134.9 In-house 1-143 (152) alignment 
Range on Protein: 371-563
Range on HMM: 1-143/152.0
FIDGNHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWpsdgsrlydkilvelteeltysdyvlrqfslthteekssrivrQF
|||| .. ...||||.| | |..||||||.|.   .|||||...| |||||..|.                                           |.
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

QCTDWPDSGLPESGVGLIDLIGQVEKWqQQSGNTCITVHCSGGVGRTGVFCAVSILIervkaeGLIDVFQTVQHLRLQRPAMVQTKDQYEFCY
... |||.| |..   |..|.  .||. ... . .. ||||.||||||...|  ...        ......|...| .|| .|....|..|.|
lhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 373-562 1.3e-14 48.4 In-house 84-280 (302) alignment 
Range on Protein: 373-562
Range on HMM: 84-280/302.0
DGNHRLKAYI-ATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSDGS-----RLYDKILVELTEELT-Y---SDYVLRQ--FSLTHTE
||  ...        |   | | .| .. . . |..| |.   | .. ||  |.  .       . |    |.. ..|  .    ...| .  .  ....
dGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkk

EKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQqqsgnTCITVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYE
.|  . |  .. . ||| | |.     .|..   | ..     . . |||| |||||| . |.   |.  . .   |. . |. .|  |   ||...|  
kkvkktvdilafsawpdhGapkeaytaldilkfcesyk.....knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqli

FC
. 
yl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 375-428 2.3e-06 21.2 In-house 232-282 (440) alignment 
Range on Protein: 375-428
Range on HMM: 232-282/440.0
NHRLKAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAgklKCHRYWPSD
  . .|.|||| |.  |  ||||.. . . . |.|| . ..     |  ||| .
yskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvn
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 379-564 3.8e-24 80.0 In-house 5-198 (199) alignment 
Range on Protein: 379-564
Range on HMM: 5-198/199.0
KAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSD--GSRLYDKILVELTEELTYSDYVLRQFSLTH--TEEKSSRIVRQFQCTD
. ||||| |.  |. |||.|.||  |  |||.  ..   .     |||.   |.  |  . |      | .||..  . ||   |   |.| . ..| | 
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDSGLPESG--VGLIDLIGQVEKWQQQSGNTCITVHCSGGVGRTGVFCAVSILIERVK--AEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYT
| .   |.    ||..    .| |  .|  .. . |||| | | |||| |. | .   .     ..|.|.  . ||  |  .. . ..|.| | 
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 379-564 4.1e-24 79.8 In-house 4-197 (198) alignment 
Range on Protein: 379-564
Range on HMM: 4-197/198.0
KAYIATQAPVPRTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPSD--GSRLYDKILVELTEELTYSDYVLRQFSLTH--TEEKSSRIVRQFQCTD
. ||||| |.  |. |||.|.||  |  |||.  ..   .     |||.   |.  |  . |      | .||..  . ||   |   |.| . ..| | 
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDSGLPESG--VGLIDLIGQVEKWQQQSGNTCITVHCSGGVGRTGVFCAVSILIERVK--AEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYT
| .   |.    ||..    .| |  .|  .. . |||| | | |||| |. | .   .     ..|.|.  . ||  |  .. . ..|.| | 
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_hpo-7_pd Subfamily hpo-7 390-568 9.3e-14 45.9 In-house 45-225 (263) alignment 
Range on Protein: 390-568
Range on HMM: 45-225/263.0
RTFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPS--DGSRLYDKILVELTEELTysDYVLRQFSLTHT--EEKSSRIVRQFQCTDWPDSGLPESGV
.| . |....  ... |.|||.  .|.|. || .|.|   |. . . .. |  |.     | .|.   |. |  | |  . |.... . |..   ||   
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelar

GLIDLIgqveKWQQQSgnTCITVHCSGGVGRTGVFCAVSILIE------RVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQE
  . ..    |  ..|    . |||| |.||.  |  . ..        .    . .|  . ...|| .|.. ..|  |  |   .. .
eilnil....kvarns..kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLd
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 391-569 8.3e-17 56.1 In-house 40-220 (255) alignment 
Range on Protein: 391-569
Range on HMM: 40-220/255.0
TFEDFWRMLWEQESAVIVMLTREEEAGKLKCHRYWPS--DGSRLYDKILVELTEelTYSDYVLRQFSLTHT--EEKSSRIVRQFQCTDWPDSGLPESGVG
| . |....  ... |.|||.  .|.|. ||..|.|   |. . . .. |  |.  . .| |||   .| |  | |  . |. .. . |..   ||    
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

LIDLIgqveKWQQQSgnTCITVHCSGGVGRTGVFCAVSILIE------RVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEY
.  ..    |  ..|    . |||| |.||.  |  . ..        .    . .|  . ...|| .|.. ..|  |  |.  .. ..
ilnil....kvvrds..ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldl
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 420-560 7.3e-07 23.0 In-house 149-292 (332) alignment 
Range on Protein: 420-560
Range on HMM: 149-292/332.0
KCHRYWPSDGSRLyDKILVELTEELTYSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPD-SGLPESGVGLIDLIG-QVEKWQQQSGnTC---ITVHCSGGV
 |...||  .|.  |   . .     .|.  .. | || ||.|  .    ..  .| | | |||  . .   |  |  .  ...|  |   | . |. ||
icrkfwpekrskk.dfpalsiqasddhsethmktfnltvtekkqdhqtvlmhfyewadasklpeymldmrasiklqyirsskktg.vcigpimlvcatgv

GRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYE
 .  ..... |.. |.  |  . . .|.  ...||   ..|   | 
ekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpys
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 436-571 3.9e-22 73.2 In-house 64-195 (440) alignment 
Range on Protein: 436-571
Range on HMM: 64-195/440.0
ILVELTEELTYSDYVLRQFslthTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSGNTCITVHCSGGVGRTGVFCAVSILIERVKAEGL
...|  . .  |||.   .     .   || ..|..   ||| |.|.    .. .| .|.. |...||  . |||| |.|||||  ||  ..  .|    
vmleevkgvpdsdyinasy....ingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdq

IDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLE
||.|  .. .| .|| |||| .|| | . .. | | 
idifsfinsmrnnrpqmvqtpeqyafvheavlegll
0048076 (Phosphotyrosine protein) phosphatases II 446-569 3.3e-25 83.8 In-house 26-142 (145) alignment 
Range on Protein: 446-569
Range on HMM: 26-142/145.0
YSDYVLRQFSLTHTEEKSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSgnTCITVHCSGGVGRTGVFCAVSILIErvkaEGlIDVFQTVQHL
 .  . . ..||...|  .| . |.....||| | |..   |.... ..|.....    .. |||| ||||||...|  ....    .| ..........
kdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelv

RLQRPAMVQTKDQYEFCYTTIQEY
| ||| .|.. .|..|.|  ..|.
rsqrpgavpnpgqlrflyefelel
subfamily_Tensin_pd Subfamily Tensin 454-522 8.6e-06 18.4 In-house 56-123 (189) alignment 
Range on Protein: 454-522
Range on HMM: 56-123/189.0
FSLTHTEEKSSRIVRQFQCTDWPDSGLPESGvGLIDLIGQVEKWQQQSGNTCITVHCSGGVGRTGVFCA
| |.. .   |.. .. .   |||   |     |  .. ....| ..  .  . ||| || ||.||  .
fnlsekrydisklnkkvldfGWPdllaPsle.klcsicksldsWlkadpqnvvvvhckGgkgrigvvvs
0048179 (Phosphotyrosine protein) phosphatases II 455-564 4.4e-23 77.0 In-house 35-139 (144) alignment 
Range on Protein: 455-564
Range on HMM: 35-139/144.0
SLTHTEE--KSSRIVRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQqsGNTCITVHCSGGVGRTGVFCAVSILIervkAEGlIDVFQTVQHLRLQRPAM
.||.. |     | . |.....||| | |..   |....  .|....   . .. ||||.||||||...|  ...     .| ..........| .|| .
nlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpga

VQTKDQYEFCYT
|.. .|..|.. 
vpnpgqlrfLle
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 463-570 1.6e-10 34.8 In-house 216-344 (349) alignment 
Range on Protein: 463-570
Range on HMM: 216-344/349.0
SSRIVRQFQCTDWPDSGL---PESGVGLI----DLIG--QVEKWQQQSGNTCITVHCSGGVGRTGVFCAVSILIE----------RVK--AEGLIDVFQT
.  .. |.|  .|.|..|   | | .  .    |||     ... ...  . . |||| | |||||.. . .|..          ..|  |     .. .
kPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisii

VQHLRLQRPAMVQTKDQYEFCYTTIQEYL
| .|| || .|||   |. ..| .. .|.
vnelrkqrismvqnlaqfiaiyealLkyf
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 465-569 2e-15 51.4 In-house 215-343 (350) alignment 
Range on Protein: 465-569
Range on HMM: 215-343/350.0
RIVRQFQCTDWPDSGL---PESGVGLID----LIGQ--VEKWQQQSGNTCITVHCSGGVGRTGVFCAVSILIE---------------RVKAEgLID-VF
 .| |.|   |.|..|   ||| .  ..    || .   |.. ...  . | |||| ||||||.....  |..                | |. . | ..
yvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaak.trDlis

QTVQHLRLQRPAMVQTKDQYEFCYTTIQEY
..|..|| ||  |||..||. |.| ... |
iivnelrkqrismvqnldqfifiYeallfy
PTPc_DSPc_SM00012 467-567 4.8e-34 112.1 In-house 2-104 (105) alignment 
Range on Protein: 467-567
Range on HMM: 2-104/105.0
VRQFQCTDWPDSGLPESGVGLIDLIGQVEKWQQQSG-NTCITVHCSGGVGRTGVFCAVSILIERVKAE-GLIDVFQTVQHLRLQRPAMVQTKDQYEFCYT
|.....|.||| |.||..  ...|. .|.|....|. .. . |||| ||||||.|.|..||......| . .|.||.|..|| ||| ||||..|| |.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

TIQ
 ..
all
PTEN_1 468-560 1.1e-07 26.9 In-house 93-183 (196) alignment 
Range on Protein: 468-560
Range on HMM: 93-183/196.0
RQFQ--CTDWPDSGLPeSGVGLIDLIGQVEKWQQQ-SGNTCITVHCSGGVGRTGVFCAvSILIERVKaeglIDVFQTVQHLRLQR-PAMVQTKDQYE
....    ...| | | |   |.| . ... | .. . . .. ||| .|.||.|. .| . |... |     .. ......| .| |.....  | .
sgveylhfpieDhgap.slselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva.ayLmykgk....ltadeAlelvrekRppgapnspsqer
0038934 (Phosphotyrosine protein) phosphatases II 473-571 1.5e-11 39.8 In-house 85-178 (194) alignment 
Range on Protein: 473-571
Range on HMM: 85-178/194.0
TDWPDSGLPESGVGLIDLIGQVEKWQQQSGNTCITVHCSGGVGRTGVFCAVSIlIERvkaEGLiDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYLE
  .|| | . |   | . .  |... ... . .. ||| .|.||||...|  . |.|    |. .. . ....|  || .... |..|  ..  .|. .
lpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYL.iyr...lgm.saeeAialfrekRpgaipnqdyleallkrykelrk
subfamily_PTEN_pd Subfamily PTEN 487-558 3e-07 25.6 In-house 98-168 (184) alignment 
Range on Protein: 487-558
Range on HMM: 98-168/184.0
LIDLIGQVEKWQQQSGNTCITVHCSGGVGRTGVFCaVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQ
| ... ..||| ... .  . |||  | |||||   |. |... . |   .. .  .. | .    |.   |
leeivediekwleedkknvvvvHCkaGkGRtGvli.vayllkslllekaeealelfaeaRtknkkgvtiPsq
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 491-566 1.5e-15 51.9 In-house 215-291 (297) alignment 
Range on Protein: 491-566
Range on HMM: 215-291/297.0
IGQVEKWQQQS-GNTCITVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTI
. |.|  . .   |. . |||| ||||.||     ....... . . ||   ...|| ||. .||| .|.|..|. .
flqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_PRL_pd Subfamily PRL 494-554 2.9e-06 21.4 In-house 81-135 (151) alignment 
Range on Protein: 494-554
Range on HMM: 81-135/151.0
VEKWQQQSGNTCITVHCSGGVGRTGVFCAVSILIERVKAEglidvfQTVQHLRLQRPAMVQ
...  .........|||  |.||. |. |.... . .| |      ..|. .| .| . . 
lkekfkeepkstvavhcvaGlGraPvlvalalieaGmkye......davefirekrrgain
subfamily_PTPDC1_pd Subfamily PTPDC1 498-564 1.3e-08 29.5 In-house 111-170 (182) alignment 
Range on Protein: 498-564
Range on HMM: 111-170/182.0
QQQSGntCITVHCSGGVGRTGVFCAVSIL-IERVKAEglidvfQTVQHLRLQRPAMVQTKDQYEFCYT
  | |   ..|||  | |||||  |. ..  .|..||      .... .| .||  .||..| |..  
alqeg..kvavhChaGlGrtGvliacylvyakrltae......kaiklvrskrpksiqtreqvelvke
subfamily_CG42327_pd Subfamily CG42327 499-570 6.2e-16 53.0 In-house 243-315 (319) alignment 
Range on Protein: 499-570
Range on HMM: 243-315/319.0
QQSGNTCITVHCSGGVGRTGVFCAVSILIERVKAE-GLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
... .  ..|||| ||||||.  |  | |....     .|. |.|...| .|   |.||.|||| | ...|| 
tresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 507-570 3.4e-16 53.4 In-house 2-65 (69) alignment 
Range on Protein: 507-570
Range on HMM: 2-65/69.0
TVHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
 |||| | |||| | |. . . |.|.| |.|.|  ||..|  || ||  . .| | . .. | |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 508-570 2.8e-16 53.6 In-house 2-64 (69) alignment 
Range on Protein: 508-570
Range on HMM: 2-64/69.0
VHCSGGVGRTGVFCAVSILIERVKAEGLIDVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQEYL
|||| | |||| | |. . . |.|.| |.|.|  ||..|  || ||  ...| | . .. | |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
subfamily_ptpA1_pd Subfamily ptpA1 537-568 9.2e-06 19.6 In-house 365-396 (418) alignment 
Range on Protein: 537-568
Range on HMM: 365-396/418.0
DVFQTVQHLRLQRPAMVQTKDQYEFCYTTIQE
..|  | .|| ||| |||  .|| ||| || .
nlfsivlklreqrpgmvqqleqylfcyktild