Gene NvecPTP-sf6-3 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily NvecPTP-sf6
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP067_AA protein Get Run
NvecP067_AA_3-279 phosphatase_domain Get Run
NvecP067_AA_291-569 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1-316 7.5e-165 542.6 In-house 2-318 (318) alignment 
Range on Protein: 1-316
Range on HMM: 2-318/318.0
IPVDEFEEHVRRLHANGELLFSQEYGAF-RSPDTVTSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANYLDGYRKQREYIAAQGPLPET
|.|...|.|||||...||||.|.|| .. ||..||||..||...|..||||.||.|.||.||.||..||...||||||||.||||....|||||.|||||
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

CHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPSSGSQNYGVIHVNMMSTVELSDYTIRSFGVKRSGSPEERMVLQYHYTAWPDHGVPNSVTSVLNFV
..|||||||||||.||||.|..||||..|.|.||||.||..|| ..|.....||||||..|.| |.|... |.|.| |||||.|||.|||.|..|.|..|
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlv

RKSSAVNLTEDYGPMVVHCSAGVGRTGTYVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAIACGDTEIQARDLRQRIKELMR
|..|........||.||||||||||||.....|..|.||.|||.|||...|..|| |||||||.||||..|.||||||.|.||||..|.|||.||.||..
rqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelre

PSTDTGQTEMDAEFQRL
.....|.||||||||||
qdpesgttemdaefqrl
subfamily_PTPRD_pd Subfamily PTPRD 1-328 5.2e-157 518.9 In-house 5-332 (564) alignment 
Range on Protein: 1-328
Range on HMM: 5-332/564.0
IPVDEFEEHVRRLHANGELLFSQEYGAFRSPDTVTSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANYLDGYRKQREYIAAQGPLPETC
|||.|..|||..|.||..| |..||  .......| ... ..||. ||||.||.|.||.|| |...|||. ||||||...|||||...|||.||||.||.
ipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaeti

HDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPSSGSQNYGVIHVNMMSTVELSDYTIRSFGVKRSGSPEERMVLQYHYTAWPDHGVPNSVTSVLNFVR
.|||||||||||..|||.|..||.|. |||.|||..|...|| ..|......||.||.||.| .|.. | | |.| |.|.|.|||||||.| ||.|...|
edFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlir

KSSAVNlTEDYGPMVVHCSAGVGRTGTYVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAIACGDTEIQARDLRQRIKELMRP
|..|.| ..| ||.|||||||||||||..|||| |.||..|.|||.|.||..|| ||| ||| |.||. ||...|||.|||.||.....|.|....|.. 
kvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLaev

STDTGQTEMDAEFQRLS-RNKAPPSKFQS
..||..|....|||||.  .. ....|..
eedtemtgleleFqrLatakeieleefav
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1-314 4.1e-118 389.1 In-house 5-319 (319) alignment 
Range on Protein: 1-314
Range on HMM: 5-319/319.0
IPVDEFEEHVRRLHANGELLFSQEYGAFRSPDTVTSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANYLDGYRKQREYIAAQGPLPETC
|.|.|..|....|...|| |. .|.  .. ....| ... .. |. ||||.|| |.|..|| |....| . ||||||...|||......||.|.|| .| 
ievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlenti

HDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPSSGSQNYGVIHVNMMSTVELSDYTIRSFGVKR-SGSPEERMVLQYHYTAWPDHGVPNSVTSVLNFV
.||||||||..| ..||.|.  |....|...|||.   ..|| . |.. .  ||.|| || . ... |.  | |.| ...||.||||.||.. ||.|...
edfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldll

RKSSAVNLTEDYGPMVVHCSAGVGRTGTYVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAIACGDTEIQARDLRQRIKELMR
..       .. ||.|||||||||||||..|.|| | |.. |...||...| .|| |||.||| ..|| .|...||||. .|||||. .|||.|.|.|  
krirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlae

PSTDTGQTEMDAEFQ
  .|||.| .. |||
kvadtgetglerefq
subfamily_PTPRG_pd Subfamily PTPRG 1-292 2.1e-113 374.5 In-house 1-301 (563) alignment 
Range on Protein: 1-292
Range on HMM: 1-301/563.0
IPVDEFEEHVRRLHANGELLFSQEYGA---FRSPDTVTSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEGDPTS-DYINANYLDGYRKQREYIAAQGPL
.||.||..||  |||.|.  ||.|. |      ..... .|| .. |. |||| ||.|.|. || |.|. |   . |||||||.|||.|....||.||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

PETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPSSGSQNYGVIHVNMMSTVELSDYTIRSFGVKR-----SG-SPEERMVLQYHYTAWPDHGVPN
..|..|||||.||||. .|||.|| .|||| ||..|||. .|..||...|.....  |. ||.|.. .|           .|..| ||||| |||||||.
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe

SVTSVLNFVRKSSAVNLtEDYGPMVVHCSAGVGRTGTYVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAIACGDTEIQARDL
. . ||.||.|||| |  .. ||.||||||||||||||.|.|. ||.||.| .|.|.. . ..| ||| .|| |.||. .||.|||||| ..||..| ..
hslpvLifvkkssaank.aeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqv

RQ
..
ee
0051299 (Phosphotyrosine protein) phosphatases II 1-278 4.6e-103 339.9 In-house 5-286 (288) alignment 
Range on Protein: 1-278
Range on HMM: 5-286/288.0
IPVDEFEEHVRRLHANGELLFSQEYGAFRSPD-TVTSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANYLDGYRKQREYIAAQGPLPET
|.|.|....|..|.|||  .. .|. ...|   ..| ...| ..|. |||| .| ..||.|| |....|...||||||.|.|||...|..||.|||||.|
isveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpnt

CHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPSSGSQNYGVIHVNMMSTVELSDYTIRSFGVKRS----GSPEERMVLQYHYTAWPDHGVPNSVTSV
..||||||||||.|||||.|...|.||.||.||||..||..|| |.|...|...|.|||.| . |..     |. |.|.| ..|||.|||||||.|....
vedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspell

LNFVRKSSAVNLtEDYGPMVVHCSAGVGRTGTYVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAI
|.|.|.   ..   . ||.|||||||||||||....|  | ....| .|||...| .|| ||. ||| ..||......|||..
ldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_PTPRA_pd Subfamily PTPRA 1-313 1.3e-100 331.5 In-house 14-330 (330) alignment 
Range on Protein: 1-313
Range on HMM: 14-330/330.0
IPVDEFEEHVRRLHANGELLFSQEYGAFRS-PDTVTSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANYLDGYRKQREYIAAQGPLPET
.||...|| .|.  |.   || .|. |. . |   |   . .. |. |||. ||  .|. || |...|| ..|||||| ..|||... ..||||||. ||
lpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeet

CHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPSSGSQNYGVIHVNMMSTVELSDYTIRSFGVKRSGS----PEERMVLQYHYTAWPDHGVPNSVTSV
 .|||||.|||.|  |||.|. .|| . ||.||||. |.  || |.|..  ...| |||.| | |.. .      ..|.| |.|.|.||| |||     .
vedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGm

LNFVRKSSAVNLTEDYgPMVVHCSAGVGRTGTYVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAIACGDTEIQARDLRQRIK
|....|  ..|  .   |.|||||||||||||..|.|| |.|..||  |||.. |  || ||  ||| . ||..|. ||||    ||||...  | ....
lkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlq

ELMRPSTDTGQTEMDAEF
.|    |.| .. .. ||
klynkitgtdkigleeef
0043336 (Phosphotyrosine protein) phosphatases II 1-276 4.3e-95 313.6 In-house 2-275 (278) alignment 
Range on Protein: 1-276
Range on HMM: 2-275/278.0
IPVDEFEEHVRRLHANGELLFSQEYGAFRSPDTVTSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANYLDGYRKQREYIAAQGPLPETC
|.| ........|..|.  |...|.  ..| .. |  ..| ..|. |||| .| ..||.|| |....||. ||||||.|.|||...|..||.|||||||.
isvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetv

HDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPsSGSQNYGVIHVNMMSTVELSDYTIRSFGVKRSGSPEERMVLQYHYTAWPDHGVPNSVTSVLNFVR
.||||||||.....|||.|...|.||.||.|||| .||..|| ..|..... .|.|||.| . |.. |..|.|.|..|||..||||||| |....|.|..
edFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflk

KSSAVNLtEDYGPMVVHCSAGVGRTGTYVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLE
.   ..   . ||..||||||||||||.....  | ... | .||... | .|| ||  .|| ..||. ....|||
avreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_Ptp69D_pd Subfamily Ptp69D 1-297 2e-91 301.3 In-house 4-305 (307) alignment 
Range on Protein: 1-297
Range on HMM: 4-305/307.0
IPVDEFEEHVRRLHANGELLFSQEYGAFR-SPDTVTSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANYLDGYRKQREYIAAQGPLPET
|..|. || ..  . . . .. .||     .    ... | .. | .||||..|.|||. || |..|.|. .||||||... ||......||||.|. .|
iaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveat

CHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPSSGSQNYGVIHVNMMSTVELSDYTIRSFGVKRSG-----SPEERMVLQYHYTAWPDHGVPNSVTS
 .|||||..||.. .|||..| .|  | ||..|||    ..|| | |...|. . |||.||.. | . .      ...| |.|||||.|.|  ||.. ..
igDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevarg

VLNFVRKSSAVNLTEdYGPMVVHCSAGVGRTGTYVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAIACGDTEIQARDLRQRI
.|.....   .. ..  .|.||||||||||.|..| .|  |....|| .||... |  || ||||.||  .||| ..  ||. .  |||... .|| ..|
llklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledai

KEL
..|
erl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1-313 6.1e-88 289.8 In-house 6-314 (315) alignment 
Range on Protein: 1-313
Range on HMM: 6-314/315.0
IPVDEFEEHVRRLHANGELLFSQEYGAFRSPDTVTSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANYLDGYRKQREYIAAQGPLPETC
||.|..  .| . .|. .  | |.| .    .    . . .  |. |||| || |.|. || |  .| || |||.|||..||| |.| |||||||.... 
ipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasv

HDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPSSgSQNYGVIHVNMMSTVELSDYTIRSFGVKRsGSpEERMVLQYHYTAWPDHGVPNSVTSVLNFVR
.||||.|.|..   |||.||  |. . |. .|||      || | | ..|    ..||.|.. |   |. . | |.|.|||.||| |||.. ....|..|
kdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtlsvvf.gd.nirevvqlhytswpdmgvpkytiplmnlir

KSSAVNlTEDYGPMVVHCSAGVGRTGTYVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAIACGDTEIQARDLRQRIKELMRP
.    . |.. |..|||||||||||||.. .|| |....||  .||||..  .| .|  |||| .|| .|.|.|||.. |||| |  .   || . |. |
tvkqhh.tnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydsllap

STDTGQTEMDAEF
| ||| | .. .|
spdtgstllqeqf
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1-316 2.6e-80 264.6 In-house 3-315 (315) alignment 
Range on Protein: 1-316
Range on HMM: 3-315/315.0
IPVDEFEEHVRRLHanGELLFSQEYGAFRSPDTVTSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANYLDGYRKQREYIAAQGPLPETC
||| .|   | . .     |||.|.  .  ||.   . . .. |  ||||.||  .|. || |. |. .| |||||| |. .. ... |||.||||. . 
ipvaqfpafvnknr..htalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasv

HDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPS--SGSQNYGVIHVNMMSTVELSDYTIRSFgVKRSGSpEERMVLQYHYTAWPDHGVPNSVTSVLNF
 ||||||....   |||||. .|  .||| ||||   . | ..| |.|...|.   .| ..| . | | .  | | | |...| |||.||.. ..|.|..
ddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrkse.esrtvtqfqftewPdkGvdkqtssllkl

VRKSSAVNLTEDYgPMVVHCSAGVGRTGTYVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAIACGDTEIQARDLRQRIKELM
...  | | .... ...|||||||||||  . ||  ...|. . .|||.|.| .|| .|  .|| |..| .|.|..|| .   .| |    . .....| 
ikevkadngkkef.sllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlh

RPSTDTGQTEMDAEFQRL
  .  .|...|  ||..|
tsvdgsgrskmtkefetl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1-280 1.3e-77 255.6 In-house 2-285 (290) alignment 
Range on Protein: 1-280
Range on HMM: 2-285/290.0
IPVDEFEEHVRRLHANGELLFSQEYGAFRSPD-TVTSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEGD--PTSDYINANYLDGYRKQREYIAAQGPLP
||||.| |.|   ||.|.  | ...... | .   | .. | . |. .||..||   |  |. |.|| |.   | .|||| |..||.....|||.|||..
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

ETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPSSGSQNYGVIHVNMMSTVELSDYTIRSFGVKRSGS-PEERMVLQYHYTAWPDHG-VPNSVTSV
.|  |||...|.... .|||.||  | |. ||.||||.|....|| .......  .|..|..| . || . |  ....| ||. |.|...| |.|  |..
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtil

LNFVRKSSAvNLTEDYGPMVVHCSAGVGRTGTYVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAIAC
| . .     .  .  ...|||||..|||........  ... . |  .||.. .  .| |.  .|| ..|| .|....|... .
lvieemykt.qrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1-285 2.7e-74 244.7 In-house 2-285 (287) alignment 
Range on Protein: 1-285
Range on HMM: 2-285/287.0
IPVDEFEEHVRRLHANGELLFSQEYGAFRS----PDTVTshHSLNQANRFKNRYNNITAFDHCRVLLQpiegDPTSDYINANYLDGYRKQREYIAAQGPL
|||..| | |.. ||.|.  |.. .  . .    .| ||  |.. . |. |||...|   |  ||||.    .   ||||| ..|||......|.|..|.
ipvekfgefvakghakgnegfknqftvleqvtqredevt..hniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPm

PETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPSSGSQNYGVIHVNMMSTVELSDYTIRSFGVKRSG-SPEERMVLQYHYTAWPDHG-VPNSVTS
 .|  .||......|  .|||... .|  . .|.||||.. |  .|  ......    ..|..| . ||... . ....| ||..|.|...| |..  |.
fntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqti

VLNFVRKSSAvNLTEDYGPMVVHCSAGVGRTGTYVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAIACGDTEI
.| . ..  . .  .  ...|||||..|||..... ..  ... . | ..||.. .   | |.  .||  .||  | |..|| . ...|  
llvieemykt.qrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys
subfamily_PTPRB_pd Subfamily PTPRB 2-279 3.8e-105 346.1 In-house 8-286 (293) alignment 
Range on Protein: 2-279
Range on HMM: 8-286/293.0
PVDEFEEHVRRLHANGELLFSQEYGAFRSPDT-VTSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANYLDGYRKQREYIAAQGPLPETC
 ...|||||....|. .| ||.||  ... ..  . . . ...|| ||||.|| ..|| || |........||||||||..||. .||.||.||||||| 
klekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetv

HDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPSS-GSQNYGVIHVNMMSTVELSDYTIRSFGVKRsgSPEERMVLQYHYTAWPDHGVPNSVTSVLNFV
.||||||||..|..|||.|.. |.|..||..|||.   ...|| |.|..... ||.|..||.. ...  . ||| | |||.|.|||||||.. ...|.||
ddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfv

RKSS-AVNLTEDYGPMVVHCSAGVGRTGTYVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAIA
|.   |.. |.. .|.|||||||||||||.. .|  |..|. | .||..  |. || .|||.|| |.||. ||...|. . 
rtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 2-297 2.8e-91 300.9 In-house 5-302 (305) alignment 
Range on Protein: 2-297
Range on HMM: 5-302/305.0
PVDEFEEHVRRLHANGELLFSQEYGAFRSPDTvTSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANYLDGYRKQREYIAAQGPLPETCH
 .|.......  ... .  . ..| .. . .. . .   ..||. |||...|| .|. |. |.. | .. ||||||.|.|||... .||.|||||..| .
alddlaayikearvysdkgleaqykslyeeee.sidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntva

DFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPSSGSQ--NYGVIHVNMMSTVELSDYTIRSFGVKR-SGSPEERMVLQYHYTAWPDHGVPNSVTSVLNF
||||...|   ..|||.|.  | |. ||.|||| | ..  ..| ..|.. |. . |||..| . .   ... |.| ||||. | |||||||.. ||.|..
dfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllsl

VRKSSAVNLTEDYGPMVVHCSAGVGRTGTYVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAIACGDTEIQARDLRQRIKEL
...       .   |..|||||||||||.....| .| |...| .|||....  || .|  |||  |||| .||.| | | ||||.|   .|| |.. |
ikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnkl
0039614 (Phosphotyrosine protein) phosphatases II 2-282 1.1e-90 299.4 In-house 15-293 (297) alignment 
Range on Protein: 2-282
Range on HMM: 15-293/297.0
PVDEFEEHVRRLHANGELLFSQEYGAFRSPDTvTSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEG-DPTSDYINANYLDGYRK-QREYIAAQGPLPET
|.. .. ......||.  |. .|.    |       ..| ..|. |||| .| ..||.|| |.|..| |. ||||||.|.|||.. .|..||.|||||||
plsvldlllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpet

CHDFWRMVWEQNSRVIVMVTNCEERGRiKCHQYWPSSGSqNYGVIHVNMMSTVELSDYTIRSFGVKRsgSPEERMVLQYHYTAWPDHGVPNSVTSVLNFV
..|||||||||...||||.|...|.|| ||.||||..|. .|| ..|..... .|..||.| . |..  . |.|.| ...|| |||||||.|....|.|.
vedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslelllefl

RKSSAVNLTE-DYGPMVVHCSAGVGRTGTYVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAIACGD
..   .. .  . ||..||||||||||||.....  | ... | .|||.. | .|| ||. .|| ..||. ..|.||| . ...
elvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 2-316 3.7e-59 195.1 In-house 5-274 (392) alignment 
Range on Protein: 2-316
Range on HMM: 5-274/392.0
PVDEFEEHVRRLHanGELLFSQEYGAFRSPDTVTSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANYLDGYRKQREYIAAQGPLPETCH
|| .|   | . .     ||..|.  . .||      . .. |  ||||.||  .|  || |. |.  | |||.|| |....  .. |||.||| . . .
pvaqfpafveknr..hsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaasld

DFWRMVWEQNSRVIVMVTNCEERGrikchqywpssgsqnygvihvnmmstvelsdytirsfgvkrsGSPEERMVLQYHYTAWPDHGVPNSVTSVLNFVRK
||||||...|   |.|||. .|                                               . | | |.|.| |||..||. ..|.|.|...
dfwrmvfqenvttiamvtklkegd..........................................kgddartvaqfhftewPdkdvpkhtssllkfike

SSAVnLtEDYG-PMVVHCSAGVGRTGTYVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAIACGDTEIQARDLRQRIKELMRP
 .|     .|  |...||||||||||  . ||. . . .    |||.|.|  .| .|  |||...|| .|.  .|| .   .| |    . .....|   
vkad.f.Gqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlsts

STDTGQTEMDAEFQRL
|   ... .  ||. |
sdGdvrskqlkefrsl
0050432 (Phosphotyrosine protein) phosphatases II 3-281 1.8e-99 328.2 In-house 28-302 (308) alignment 
Range on Protein: 3-281
Range on HMM: 28-302/308.0
VDEFEEHVRRlhANGELLFSQEYGAFRSPD-TVTSHHSLNQANRFKNRYNNITAFDHCRVLLqpiegDPTSDYINANYLDGY--RKQREYIAAQGPLPET
|... ... .  |..  |...|. ...|     .  ..| ..|. |||| .| ..||.|| |     |..||||||.| |||  ...|..||.|||||.|
vldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpnt

CHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPSS---GSQNYGVIHVNMMSTVELSDYTIRSFGVKRSGSPEERMVLQYHYTAWPDHGVPNSVTSVL
..||||||||||.|||||.|...|.||.||.||||..   ||..|| ..|...|. .|.|||.| . .. .|..|.|.| ..|||.|||||||.|....|
vedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeill

NFVRKSSAVNlteDYGPMVVHCSAGVGRTGTYVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAIACG
.|...   ..   . ||.|||||||||||||....|  | ....| .|||...| .|| ||. ||| ..||......||| . . 
dflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklk
0045450 (Phosphotyrosine protein) phosphatases II 3-278 2.5e-90 298.6 In-house 11-304 (307) alignment 
Range on Protein: 3-278
Range on HMM: 11-304/307.0
VDEFEEHVRRLHANGELLFSQEYGAFRSPDTV---TSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEGD-PTSDYINANYL--------DGYRKQREYI
.  .. .|..|....  .. .|.  ..|  .    .  ..| ..|. |||| .| ..||.|| |....|. ..||||||.|         |||...|..|
alkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfI

AAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPSSGSQ-NYGVIHVNMMSTVELSDYTIRSFGVKRS-GSPEERMVLQYHYTAWPDHGV
|.|||||||..|||||.|||...||||.|...|.||.||.||||..|.. .|| ..|...|. .|..||.| . |... |. |.|.| ..|||.||||||
atqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgv

PNSVTSVLNFVRKSSAVNLTE-DYGPMVVHCSAGVGRTGTYVVIDAQLKRIQAEAT---VDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAI
| |. ..|.|...  ... .  . ||..||||||||||||.....  |.....| |   ||... | .|| ||  .|| ..||. ....||| .
ppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_PTPN9_pd Subfamily PTPN9 3-276 9.6e-86 282.5 In-house 3-288 (297) alignment 
Range on Protein: 3-276
Range on HMM: 3-288/297.0
VDEFEEHVRRLHANGellFSQEYGAFRS-PDTVTSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANYLDGYRKQREYIAAQGPLPETCH
..|....|.  . .|    |.|| . |. | . | ..|  .||  ||||...  .|. || |. ...|..|||||||..|||.... .||.||||..|..
ieelvayvkekgkrG...lskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvs

DFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWP--SSGSQNYGVIHVNMMSTVELSDYTIRSFGVKRSGSPEERMVLQYHYTAWPDHGVPNSVTSVLNFV
|||||||||. .||||.| ..||||.|| ||||  .  |...| ..|. ....| .||..|.. .|..   |.| |  . ...|||.|||.| .|.|...
dfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvl

R---KS--SAV-NLTED------YGPMVVHCSAGVGRTGTYVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLE
.   .   .|| .|...        |.|||||||.|||||.. .|  |.|.. ..|||| . | .|| ||  ..|...||.. .  .||
ekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 3-94 1.9e-13 44.4 In-house 7-95 (95) alignment 
Range on Protein: 3-94
Range on HMM: 7-95/95.0
VDEFEEHVRRLHANGELLFSQEYGAFRSPDTVTSHHSLNQANRFKNRYNNITAFDHCRVLLQpieGDPTSDYINANYLDGYRKQREYIAAQG
|  |  ||  .|.| .  | .|. .       .      .||  |||. ||  .|  || |        |||||| ..||| ..  ||||||
vsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlt...tkrdsdyinacfvdgyarkncyiaaqg
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 4-292 3.1e-82 271.4 In-house 5-293 (439) alignment 
Range on Protein: 4-292
Range on HMM: 5-293/439.0
DEFEEHVRRLHANGELLFSQEYGAFR--SPD-TVTSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANYLDGYRKQREYIAAQGPLPETC
|||.||| .|. | . .|....      ||| .. .    .. .. ||||....|||| || || | | | | ||||||..|| ... |||.|||  ||.
defqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkett

HDFWRMVWEQNSRVIVMVTNCEERGRikchqYWPSSGSQNYGVIHVNMMSTVELSDYTIRSFGV--KRSGSPEERMVLQYHYTAWPDHGVPNSVTSVLNF
.||||.|.|...  |||.||  |  .     ||||..   || | | .   .|| .|.|| | |  .|  .  || |||.||.||||. ||   . ||.|
ddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldf

VRKSSAVNLTEDYGPMVVHCSAGVGRTGTYVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAIACGDTEIQARDLRQ
.|   . | .|.|||.||||||||||||| . .|  |.....|  ||.   | .|| ||. |||   |||.|.. .|| |  ||. ..  ....
lrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkk
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 4-313 4.4e-75 247.8 In-house 8-323 (325) alignment 
Range on Protein: 4-313
Range on HMM: 8-323/325.0
DEFEEHVRRLHANGELLFSQEYGAFRSPDTVTSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANYLDGYRKQREYIAAQGPLPETCHDF
 .. ||| . .|. .  |..|.|   | |... . .   .|. |||..|. |.|. || |.  . || ||||||.||  ..|.  ..||| ||..| .|.
vnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindl

WRMV--WEqnSRVIvMVTNCEERGRIKCHQYWPSS--GSQNYGVIHVNMMSTVELSDYTIRSFGVKRSGSPEERMVLQYHYTAWPDHGVPNSVTSVLNFV
||.|  |.  . |. .|.|  . |  .| .|||     |...| ..|....  |.|||  | . ||.    | | | |... .|.| ||..  .......
WrlvldWr..csvv.vvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisil

RKSSAV----NL-TEDYGPMVVHCSAGVGRTGTYVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAIACGDTEIQARDLRQRI
.   ||    .  |.  .|..|||||||||||... . . |...  |. ||....|  || .|  ||.  |||.||.. | ||. .|.|..    .  ..
qlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeakl

KELMRPSTDTGQTEMDAEF
  |      | . ... ||
sslqernpltqklniekef
0040438 (Phosphotyrosine protein) phosphatases II 5-316 2e-100 331.4 In-house 4-314 (317) alignment 
Range on Protein: 5-316
Range on HMM: 4-314/317.0
EFEEHVRRLHANGELLFSQEYGAFRSPDTVTSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANYLDGYRKQREYIAAQGPLPETCHDFW
...... .|....  ....|.  ..| .  |  ... ..|. |||| .|  .||.|| |.|..||. ||||||.| ||....|..||.|||||.|..|||
dlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFw

RMVWEQNSRVIVMVTNCEERGRIKCHQYWPSSGSQNYGVIHVNMMSTVELSDYTIRSFGVKRSGSPEERMVLQYHYTAWPDHGVPNSVTSVLNFVRKSSA
||||||...||||.|..||.||.||.||||. ....|| ..|...|..||...|.| . |. .|..|.|.| ..|||.||||||| | ...|.|...  .
rmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavre

VNLtEDYGPMVVHCSAGVGRTGTYVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAIACGDTEIQARDLRQRIKELMRPSTDT
..  .. ||..||||||||||||.....  | ... | .|||.. | .|| ||. .|| ..||. ..|.||| . ...| . | .|  ....| .| . .
ale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplald

GQTEMDAEFQRL
. .... |...|
dvklkekelkll
subfamily_PTPRK_pd Subfamily PTPRK 5-314 3.5e-99 326.6 In-house 8-313 (314) alignment 
Range on Protein: 5-314
Range on HMM: 8-313/314.0
EFEEHVRRLHANGELLFSQEYGAFRSPdtvtSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANYLDGYRKQREYIAAQGPLPETCHDFW
.  ...  |...    | .|| ..          . .. || |||...| |.|..|| |..|.||| ||||||...|.|.. ...|..||||.|| .|||
dllqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfW

RMVWEQNSRVIVMVTNCEERGRIKCHQYWPSSGSQnYGVIHVNMMSTVELSDYTIRSFGVKR--SGSPEERMVLQYHYTAWPDHGVPNSVTSVLNFVRKS
|.|...|.  |||.|.  | ||.|| .|||  ... || |.|....|  |... .| | |..   |  | |.| |.....||||.||.| |..|..||. 
rlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrv

SAVNLTeDYGPMVVHCSAGVGRTGTYVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAIACGDTEIQARDLRQRIKELMRPST
 . .   . |..||||||| |||||...||  |  |. | .|||.| |  || ..  ||..|.||..|.||.|||  ||.| | . ...   .| .|  .
kksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesirldp

DTGQTEMDAEFQ
.|  ...  |||
qtnssqlkeefq
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 7-278 1.4e-89 295.0 In-house 3-276 (281) alignment 
Range on Protein: 7-278
Range on HMM: 3-276/281.0
EEHVRRLHANGELLFSQEYGAFRS-PDTVTSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANYLDGYRKQREYIAAQGPLPETCHDFWR
..|...|..| .  | .|| ....     |.. | ...|. ||||.||.|.|. || ..| | . ..||||||...||....||||.|||.|.....||.
rkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWq

MVWEQNSRVIVMVTNCEERGRIKCHQYWPSSG-SQNYGVIHVNMMSTVELSDYTIRSFGVKRSGSpEERMVLQYHYTAWPDHGVPNSVTSVLNFVRKSSA
|||||. ..|||||.  | |..|||.|||    . .|| ..|..... | . |  | | ..|... |.| | | .||||||||||.. . .|.| ..   
mvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresg.etreveqlaytaWPdhGvPattkellefrkevlk

VNLTEDYGPMVVHCSAGVGRTGTYVVIDAQLKRIQAE-ATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAI
.. ..   |.|.||||||||||||. .|  .|...|| ...|| . |. || .||||||   ||  .. ..|.|.
ltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 7-284 5.8e-59 194.2 In-house 6-299 (301) alignment 
Range on Protein: 7-284
Range on HMM: 6-299/301.0
EEHVRRLHANGellFSQEYGAFRSPDTVTSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEG--DPTSDYINANYLDGYRKQREYIAAQGPLPETCHDFW
..||   |.|.   |...| . .. .  ... .|...|.  ||..||| .|. |..|.| .     . .||||.|.|||......||||||. .|  |||
gthvaakhsnk...feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfW

RMVWEQNSRVIVMVTNCEERGRIKCHQYWPSSGS--QNYGVIHVNMMSTVELSDYTIRSFGVKRS-GSP--------------EERMVLQYHYTAWPDHG
|..|..    |||||| .|. . ||.||||.|    ...| ..| ....  . |..||.. ||   ||               . . |||.. | ||..|
rliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdG

VPNSVTSVLNFVRKSSAVNLTEDYGPMVVHCSAGVGRTGTYVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAIACGDTE
|      ||. . .    .   . ||.|||||..|.|.|.|. ..  |   .||  |||.. .  .| ..  .|.  .||. |.||. . ... .|.
vvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnsty
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 8-278 4.6e-88 290.0 In-house 10-279 (288) alignment 
Range on Protein: 8-278
Range on HMM: 10-279/288.0
EHVRRLHANGELLFSQEYGAFRSPDTVT-SHHSLNQANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANYLDGYRKQREYIAAQGPLPETCHDFWRM
..| . .|...  ||.|| .  . .    .. . .  |  ||||.|| ..|. || |.  |  ...|||||.|.||..|...|||.||||..| .|||..
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

VWEQNSRVIVMVTNCEERGRIKCHQYWPSSGS-QNYGVIHVNMMSTVELSDYTIRSFGVKRSGspEERMVLQYHYTAWPDHGVPNSVTSVLNFVRKSSaV
|.|...  |||.|.  |.|. ||..|||...  .||| . | .... || |.. |.. .....  .|. . ||.|.||||||||.| . .|...|.   |
vyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkk..teleitqyqylaWpdhgvPeskapllellrqvk.v

NLTEDYGPMVVHCSAGVGRTGTYVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAI
. ..| ||..||||||||||||....|| ......| ..|| . |  || ||.|.||.. ||. |..|||. |
anqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 16-292 2.6e-63 208.6 In-house 6-280 (283) alignment 
Range on Protein: 16-292
Range on HMM: 6-280/283.0
NGELLFSQEYGAFRSPDTVTSHHSLNQaNRFKNRYNNITAFDHCRVLLQPIEGdptsDYINANYLD---GYRKQREYIAAQGPLPETCHDFWRMVWEQNS
|.  || . .  .  ||  .  .| .. |. |||...| . |  || |..       ||||| ..     |.....||.||.|| .|  |||.||.... 
nnnklfrevlkrlsvpdldadiasade.nkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdeki

RVIVMVTNCEERGRIKCHQYWPSSGSQNYGVIHVNMMSTVELSDYTIRSFGVKRSGSPEERMVL-QYHYTAWPDHGVPNSVTSVLNFVRKSSaVNLTEDY
  |||.|.  |  |||| ||||. ||..||   | .   .    ..|. . .. ..| .. ..|  | .  | . |    . |...| .  |     .  
taivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvis.lqteskk

GPMVVHCSAGVGRTGTYVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAIACGDTEIQARDLRQ
||.|||||.|.|||.... . | .| ...|. |||.. | ..| ||  .||  ||| |.|.. ||   ||||.| | || .
gPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdlqs
subfamily_PTPN3_pd Subfamily PTPN3 17-277 2.7e-73 241.3 In-house 15-274 (280) alignment 
Range on Protein: 17-277
Range on HMM: 15-274/280.0
GELLFSQEYgAFRSPDTVTSHHSLNQANRFKNRYNNITAFDHCRVLLQpieGDPTsDYINANYLD----GYRKQREYIAAQGPLPETCHDFWRMVWEQNS
|..| . |   .|    .. ...   .|  |||| .|...|. || |.     .| |||||||..    .      |||.||||..|..|||.|||||.|
Gavlaqfeq.lyrkkpglaisaarkpenlsknryrdilpydatrvklk...eset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqks

RVIVMVTNCEERGRIKCHQYWPSSG-SQNYGVIHVNMMSTVELSDYTIRSFGVKRSGSPEERMVLQYHYTAWPDHGVPNSVTSVLNFVRKSSAVNLTEDy
..|||.|.  ||||.|||||||... ...|| ..|.. .. | . | .| . .|.. . |||..||  |.||||||||.. ...|.||..  ..  ... 
slivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgke.

GPMVVHCSAGVGRTGTYVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEA
 |.|||||||.|||| .....  |  |.|.  | . . | ..| ||  .|| ..|| .. . .|..
ePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 19-324 8.5e-77 253.4 In-house 18-323 (515) alignment 
Range on Protein: 19-324
Range on HMM: 18-323/515.0
LLFSQEYGAFRSPDTVTSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANYLDGYRKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMV
 |||.|.  .  |.      . .. |  ||||.||  .|  || |. |. .| |||.|| |. ..  .. |||.|||.. .  ||||.|...|   |.||
tlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamv

TNCEERGRIKCHQYWPS--SGSQNYGVIHVNMMSTVELSDYTIRSFGVKRSGSpeERMVLQYHYTAWPDHGVPNSVTSVLNFVRKSSAVNLTEDyGPMVV
|. .|  .||| .|||   . | ..| |.|...|.   .. ..| . | ..     | | |.|.| |||.|||.  .|.| ....  | .      |...
tklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hplii

HCSAGVGRTGTYVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAIACGDTEIQARDLRQRIKELMRPSTDTGQTEMDAEFQRL
|||||||||| .. ||  . ...   .|||.|.|  .| .|  .|| ..|| .|....|| .   .| |    . . ...|       |.. |  ||| |
hcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqtl

-SRNKAPPS
 |    ||.
kslcpdppa
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 20-288 4.1e-72 237.8 In-house 27-294 (297) alignment 
Range on Protein: 20-288
Range on HMM: 27-294/297.0
LFSQEYGAFRSPDTVTSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANYLDGYRKqrEYIAAQGPLPETCHDFWRMVWEQNSRVIVMVT
.||.|.    .  . ..  . .. |  |.||.||  .|  || |. .. || |||.|| .. |...  ..|. | | ..|  |||.||....  .|||..
vfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmln

NCEERGRiKCHQYWPSSGSQNYGVIHVNMMSTVELSDYTIRSFGVKRSGSPEERMVLQYHYTAWPDHGVPN--SVTSVLNFVRKSSAVNLTEDYGPMVVH
. .|| . || .||. .|....| . | ..|. | . .  |.. |... .  .|.| ||... |||. |..  |..|.|...     .  ..  ||..||
ddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvh

CSAGVGRTGTYVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAIACGDTEIQAR
|.||||||| .. ||  . ... | .||....| .|| .|  .|| ..|| ... ..|||. . ||.||| 
claGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqas
subfamily_CG7180_pd Subfamily CG7180 21-282 2.6e-66 218.3 In-house 19-294 (296) alignment 
Range on Protein: 21-282
Range on HMM: 19-294/296.0
FSQEYGAFRSPDTVTSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANYLDGYRKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTN
. .|.      .. .  . |.. || |||. ..  .|. ||.|. ..|. .|||||| | |.. |..|||  ..|  || ..|||.|.....  .|..|.
yklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtk

CEERGRiKCHQYWPSSGSQNYGVIHVNMMSTVELSDYTIRSFGVKRS----------GSPEERMVLQYHYTAWPD-HGVPNSVTSVLNFVRKSSAVNLT-
  .  . ....|||  . ..|| | |..... .... .|| | ...            . |.|.|.....| |.  . || | .......|.   .    
tfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekv

---EDYGPMVVHCSAGVGRTGTYVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAIACGD
   ...||.||..| |..|.| |. ||| |  .. |  |||...| .|| .|. .|.  ..|  | ||||||. |. 
dedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 24-286 9.2e-98 322.2 In-house 32-298 (298) alignment 
Range on Protein: 24-286
Range on HMM: 32-298/298.0
EYGAFRSPDT----VTSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANYLDGYRKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVT
|.  ..|        ... . ...|. |||| .| |.|..||.|. ...|  |||||| .|..|...  .||.|.||.|| .||||||.|... .|||.|
efqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmlt

NCEERGRIKCHQYWPSSGSQNYGVIHVNMMSTVELSDYTIRSFGVKRSGSPEERMVLQYHYTAWPDHGVPNSVTSVLNFVRKSSAVNLTEDYGPMVVHCS
| || ...|.|.|||..|...|| |.|...|. | .|...| . |... . .||.| | |.| |||.|||.  ||||...||  | .      |..|.||
nleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCs

AGVGRTGTYVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAIACGDTEIQ
|||||.||...||. | |...| .|||...| .|| .|  .|| |.||| |... |||......||.
aGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndeie
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 25-82 1.4e-10 35.1 In-house 28-85 (440) alignment 
Range on Protein: 25-82
Range on HMM: 28-85/440.0
YGAFRSPDTVTSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANYLDG
.  . |  .  |. .    |. |||| || |.||.||.|. ..| | |||||| |..|
wsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying
subfamily_PTPN12_pd Subfamily PTPN12 27-278 5.1e-80 263.5 In-house 23-277 (290) alignment 
Range on Protein: 27-278
Range on HMM: 23-277/290.0
AFRSPDTVTSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANYLDGYRKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGR
.... ........ .. |. |||| .|  .|. || |. ||... |||||||.. |  .. ||||||||||.| .|||||.||.| ...||. .  | |.
kykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgk

IKCHQYWPSSGSQN--YGVIHVNMMSTVELS-DYTIRSFGVKRSgsPEERMVLQYHYTAWPDHGVPNSVTSVLNFVRKSSAVNLtEDYGPMVVHCSAGVG
.||..|||..| ..  .| ..|....   .. |..||.. |...   |.|.| |.|||||||||||.|..|.|.....   ..  ..  |.|||||||||
kkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvG

RTGTYVVIDAQLKRIQAEAT---VDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAI
|||| ..||   . ..|| .   .||.. |. || ||. .|| ..||.|..  ..| .
rtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
0047943 (Phosphotyrosine protein) phosphatases II 28-278 1.5e-92 305.2 In-house 21-272 (273) alignment 
Range on Protein: 28-278
Range on HMM: 21-272/273.0
FRS-PDTVTSHHSLNQANRFKNRYNNITAFDHCRVLLqpieGDPTSDYINANYLDGYRKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGR
..| .. .|  ..| ..|. |||| .| ..||.|| |    ||..||||||.|.|||...|..||.|||||.|..||||||||||.|||||.|...|.||
llslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgr

IKCHQYWPSSG---SQNYGVIHVNMMSTVELSDYTIRSFGVKRSGSPEERMVLQYHYTAWPDHGVPNSVTSVLNFVRKSSAVNLTE-DYGPMVVHCSAGV
.||.||||..|   |..|| ..|...|. . .|||.| . ....|..|.|.| ..||| ||||||| |..|.|.|...   .. .  . ||.||||||||
ekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGv

GRTGTYVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAI
|||||....|  | ....| .|||...| .|| ||  ||| ..||......||| .
gRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 29-276 4e-51 168.9 In-house 28-275 (307) alignment 
Range on Protein: 29-276
Range on HMM: 28-275/307.0
RSPDTVTSHHslNQANRFKNRYNNITAFDHCRVLLQpIEGDpTSDYINANYLDGYRKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIK
..|..|| .    .||  ||||... . |..|.... ..|  .|||| ||||    | . .|.||||| .| ..|| |. ...   ..|. .. | ..||
ktpegvtvea..fsantdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakik

CHQYWPSSGSQNYG------VIHVNMMSTVELS--DYTIRSFGVKRSGSPEERMVLQYHYTAWPDHGVPNSVTSVLNFVrksSAVNltEDYGPMVVHCSA
|.||||    |.         | |. . . .|.  .  |    .|   . . | . .. .. |||.|||.   . .|..   .||.   |  |.||||||
ceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainll...eavr..ydtnpvvvhcsa

GVGRTGTYVVIDA-QLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLE
||||.|| | |   | | |. .   |. . |  || ||.  .| | ||. .| ||||
GvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 29-118 1.1e-11 38.9 In-house 24-116 (347) alignment 
Range on Protein: 29-118
Range on HMM: 24-116/347.0
RSPDTVTSHHSlnQANRFKNRYNNITAFDHCRVLLQPIE-----GDPTSDYINANYLDGYRKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMV
 ||  .||     . .  ||| ..    |  ||.| | .      |..  |||| ..     ..||| .| |||.|  |||.||   .   .| .
yspskftsvew..ekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 30-296 1.3e-80 266.1 In-house 47-309 (319) alignment 
Range on Protein: 30-296
Range on HMM: 47-309/319.0
SPDTVTSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANYLDGYRKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTnceergRIKC
...  .  ..  . |. |||. || |||. .| |....|   |||||| ...||...  ||||||||..|  |||||.||.|.  ||..|      . ||
gvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkc

HQYWPSSGSQNYGVIHVNMMSTVELSDYTIRSFGVKRSG-SPEERMVLQYHYTAWPDHGVPNSVTSVLNFVRKSS-AVNLTEDYGPMVVHCSAGVGRTGT
 ||||  . ....  .|.. |  | ..|..|.. . . |   . | . |.|.  |||.|||.. . .. .|.| .   .  ..  ..||||||||||||.
sqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGv

YVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAIACGDTEIQARDLRQRIKE
|.|.|. |.|.. |  |||||.|  || ||| .||   || .|.  |||    | ...   |.   ..|
yivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpaylee
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 30-277 5.2e-45 148.5 In-house 19-258 (267) alignment 
Range on Protein: 30-277
Range on HMM: 19-258/267.0
SPDTVTSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEGDptsdYINANYLDGYRKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEErGRIkc
|... |   |. . |. .||...   .|. || |.  | .    |||| |..||.... .|. |.||  |  ||. .. .|.  |||..|.  . . |  
sdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvft.dni..

HQYWPSS--GSQNYGVIHVNMMSTVELSDYTIRSFGVKRSGSPEERmVLQYHYTAWPDHGVPNSVTSvlNFVRKSSAVNLTEDYGPMVVHCSAGVGRTGT
...||     ...|  . |.     |  || | .. .|         |  |.|  |      .       ..   .  .| .   |.||.||.||||.||
rlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahn.vtlyyykkwnintnnkpylk..plfgilaknqlengnrPlvvacsdGvGrsGt

YVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEA
..|||.||.|.. | ..|...... .| ||  .|.. ..|. ||..| | 
flvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 30-139 4.5e-15 49.9 In-house 82-184 (244) alignment 
Range on Protein: 30-139
Range on HMM: 82-184/244.0
SPDTVTSHHSLNQANRFKNRYNNITAFDHCRVLLQpiEGDPTSDYINANYLDGYRKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERgrikc
 ||    . ..|  | .|||      ||  || |   .|     |||| ..    .  ||| .| || .|  |||.|. |.   |.|..   ||      
rpdpsvmkdafnpnnswknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....

HQYWPSSGSQ
 .||| |   
deywpdsepl
0046845 (Phosphotyrosine protein) phosphatases II 31-283 6.1e-96 316.4 In-house 15-279 (284) alignment 
Range on Protein: 31-283
Range on HMM: 15-279/284.0
PDTVTSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEGD-PTSDYINANYLDGY-----RKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEER
. ... ...| ..|. |||| .| ..||.|| |....|| ..||||||.|.|||     ......||.|||||.|..||||||||||.|||||.|...|.
klllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelven

GRIKCHQYWPSSG-SQNYGVIHVNMMSTVELSDYTIRSFGVKRSG-SPEERMVLQYHYTAWPDHGVPNSVTSVLNFVRKSSAVNLT-EDYGPMVVHCSAG
||.||.||||..| ...|| ..|...|. . .|||.| . ... | . |.|.| ..|||.||||||| |....|.|.|.   ..   .. ||.|||||||
grekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaG

VGRTGTYVVIDAQLKRIQAEA---TVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAIACGDT
||||||....|  |.....|    .|||...| .|| ||. ||| ..||......|||.. .. |
vgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt
0045098 (Phosphotyrosine protein) phosphatases II 31-282 7.8e-83 273.3 In-house 20-276 (278) alignment 
Range on Protein: 31-282
Range on HMM: 20-276/278.0
PDTVTSHHSLNQANRFKNRYNNITAFDHCRVLlqpiegdptsDYINANYLDGYrkQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCH
..  .  ..|   |. |||| .| ..||.||           |||||.|.|||  ....||.|||||.|..|||||.||....||||.|...|.||.||.
gipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekca

QYWPSSGSQNYGVIHVNMMSTVELSDYTIRSFGVKRS----GSPEERMVLQYHYTAWPDHGVPNSV--TSVLNFVRKSSAVNL------------TEDYG
||||..||..|| ..|...|. .|.|||.| . |        . |.| | ..||. |||||||..   .|.|....   ...              .. |
qywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsgg

PMVVHCSAGVGRTGTYVVIDAQLKRIqaEATVDVYNYVMMLRGQRNL-MVQVEDQYVLIHDVLLEAIACGD
|..||||||||||||.|...  |...  | .||....| .|| ||.  .|| ..||. ....||| . .|.
pvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrgk
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 31-278 4.7e-21 69.7 In-house 36-279 (303) alignment 
Range on Protein: 31-278
Range on HMM: 36-279/303.0
PDTVTSHHSLNqaNRFKNRYNNITAFDHCRVLLQpiegdpTSDYINANYLDgYRKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCH
| .|. .. ..  |  |||. ..  .|| .| |        | || |.||.    ..  | .| ||. |. |||.|. ||. ......    |  ..  .
ppsvsknqfvk..nmdknrfvdvicldhskvkls......dssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggd

QYWPSSGS---QNYGVIHVNMMSTVELSD-YTIRSFGVkrSGSPEERMVLQYHYTAWPDHGVPNS--VTSVLNFVRKSSAVNLTEDYGPMVVHCSAGVGR
  .|        .  .| |  .  |||.| ....   |  |      ..  .|| |||   .|.      | .  .  | .    |  | |    .|.||
svfprnqdflkfeersirvgefkrvelgdgwvlkvlsv..sngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgr

TGTYVVID-AQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAI
.||. ... |.|   . .|..|. . . ..|  |   ||   |. ... .| | .
agtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv
subfamily_PTPN6_pd Subfamily PTPN6 32-275 5.8e-84 276.7 In-house 42-294 (306) alignment 
Range on Protein: 32-275
Range on HMM: 42-294/306.0
DTVTSHHSLNQANRFKNRYNNITAFDHCRVLLQpIEGDPTSDYINANYLDGY--RKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKC
.... ...  . |. ||||.||  ||| || |.  .. | ||||||||...    ....|||.|| |..|  |||||||..|||||||.|.  |||. ||
kllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekC

HQYWPSSGS-QNYGVIHVNMMSTVELSDYTIRSFGVK-RSGSPEERMVLQYHYTAWPDHGVPNSVTSVLNFVRKSSAVNL---TEDYGPMVVHCSAGVGR
 .|||.. . ..||.|.|...|  .|.||..|.. |. .. . ||| | |||...|||||||..   ||.|... .. .    ... ||.|||||||.||
arYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGR

TGTYVVIDAQLKRIQ---AEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLL
|||..|||. || |.    .| .|... |...| ||. .||.|.|| ... .. 
tGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 32-297 1.3e-79 262.6 In-house 13-274 (284) alignment 
Range on Protein: 32-297
Range on HMM: 13-274/284.0
DTVTSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANYLDGYRKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTnceergRIKCHQ
.. .  ..  . |. |||. .| |||. .| |... |   |||||| .. ||...  |||.||||..|  |||||.||.|.  ||..|      . || |
ngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsq

YWPSSGSQNYGVIHVNMMSTVELSDYTIRSFGVKRSG-SPEERMVLQYHYTAWPDHGVPNSVTSVLNFVRKSS-AVNLTEDYGPMVVHCSAGVGRTGTYV
|||  . ....  .|.. |  | ..|..|.. . . |   . | . |.|.  |||.|||.. . .. .|.| .   .  ..  ..||||||||||||.|.
ywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyi

VIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAIACGDTEIQARDLRQRIKEL
|.|. |.|.. |  |||||.|  || ||| .||   || .|.  |||    | ...   |.   ..||
vldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleel
subfamily_PTPN14_pd Subfamily PTPN14 32-278 2.1e-60 199.3 In-house 38-296 (300) alignment 
Range on Protein: 32-278
Range on HMM: 38-296/300.0
DTVTShHSLNQANRFKNRYNNITAFDHCRVLLQPIEGDpTSDYINANYLDG--YRKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKC
|...|  . .. |  |||....  ....|| |.| . . ...||||  .      |.|.||.|||||. |..|||.|||||. ..|||.|. || |. |.
dalls.taklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeks

HQYWPSSGSQ----NYGVIHVNMMSTVELSDYTIRSFGVKRSGSPEERMVLQYHYTAWPDHGVPNSVTSVLNFVRKSSAVNL--------TEDYGPMVVH
..|.|...|.    ..|  .|    . . . .. ... .|   | ||| |.   || |||||||. |.. |.....  .|          .|   |..||
fkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvh

CSAGVGRTGTYVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAI
|||||||||  .. |  .. .. . ..|. . . .|| || |.||   ||  ...||.. .
CsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_egg_pd Subfamily egg 32-275 1.6e-31 104.1 In-house 28-267 (307) alignment 
Range on Protein: 32-275
Range on HMM: 28-267/307.0
DTVTSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANYLDGYRKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERgrIKCHQ
| .. ...... |. | | . .   | .|| |.  .|  . |.| ||...|     |.| || || .| .||||||.... . |||.|   |    .|. 
deislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..ercey

YWPSSGSQNY----GVIHVNMMSTVELSDYTIRSFGVKRSGSPEERMVLQYHYTAWPDHGvpnSVTSVLNFVRKSSAVNltEdygPMVVHCSAGVGRTGT
||| . |..     | .... .   . .|   |   .|  |. .| . |..    .   .    | | |. .||   .   .   |.||..  || ...|
ywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgdvnnss...dvysplrvlrklrnls..k...pvvvqdilGvskaat

YVVIDAQLKRIQAEAT--VDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLL
 | |.  |  .    .    | . |..|| .|.| |.   .|.... ..|
lvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
0036941 (Phosphotyrosine protein) phosphatases II 33-289 3.3e-93 307.5 In-house 28-288 (297) alignment 
Range on Protein: 33-289
Range on HMM: 28-288/297.0
TVTSHHSLNQANRFKNRYNNITAFDHCRVLLqpieGDPTSDYINANYLDGYRKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQY
  .  ..|...|. |||| .| ..||.|| |    .|. ||||||.|.|||. .|..||.|||||.|..||||||||||..||||.|...|.||.||.||
lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqy

WPSS--GSQNYGVIHVNMMSTVE--LSDYTIRSFGVKRSGSPEERMVLQYHYTAWPDHGVPNSVTSVLNFVRKSSAVNLTE-DYGPMVVHCSAGVGRTGT
||.   .|..|| ..|...|. .  |.|||.| . |.  |..|.|.| ..||| |||||||.|..|.|.|...   |.    . ||..|||||||||.||
wpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgt

YVVIDAQLKRIQ---AEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAIACGDTEIQARD
....|  | ...    | .||....| .|| ||. .|| ..||. ....||| . ...| .....
fiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllk
subfamily_PTPRN_pd Subfamily PTPRN 34-275 9.6e-60 196.8 In-house 46-289 (297) alignment 
Range on Protein: 34-275
Range on HMM: 46-289/297.0
VTSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANY-LDGYRKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQY
 |.. . .. |  |||.... ..|| || |.    . .||||||   ||   ..  |||.||||..|  |||.||||| . |||..|. || |  .|..|
stkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckry

WPSSGSQNYGVIHVNMMST-VELSDYTIRSFGVKRSGSPEERMVLQYHYTAWPDHGVPNSVTSVLNFVRKSSAVNLTeDYGPMVVHCSAGVGRTGTYVVI
||  ||. |..  |...|  .   || .||| .|   . | | | |.|. .||..||| |  |.|.| ||           |.|||||.|.||||.|..|
wpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG.rscpivvhcsdGaGrtGvyili

DAQLKRIQAE-ATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLL
|  |.|..     .|.   .  || ||. .|. .||. ..  .. 
dlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltava
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 34-276 3.1e-42 139.4 In-house 37-285 (305) alignment 
Range on Protein: 34-276
Range on HMM: 37-285/305.0
VTSHHSLNQA-NRFKNRYNNITAFDHCRVLLqpiEGDPTSDYINANYLDGYRKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQY
.   ... .| .. |||| ..  .|. || |   ||    .|| |||.    . . .| .| || .|| ||| | ....   | |. |  |.|  ||..|
fekmkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcley

WPSSGSQNY------GVIHVNMMSTVELS-----DYTIRSFGVKRSGSP-EERMVLQYHYTAWPDHGVPNSVTSVLNFVRKSSAVNltedyGPMVVHCSA
..|   .          | | . |.|.|.     . ...   .   |.  . | | .||.  ||| ||| . ...|... |. .       ||.||||||
faskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk.....gpivvhcsa

GVGRTGTYVVIDAQLKRIQAEATVDVYNYV-MMLRGQRNLMVQVEDQYVLIHDVLLE
|.||||. |...  |... |   ..  . . . .| |||  .| ..||...|.|.|.
gigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
subfamily_CG42327_pd Subfamily CG42327 34-198 4.5e-33 109.2 In-house 18-186 (319) alignment 
Range on Protein: 34-198
Range on HMM: 18-186/319.0
VTSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANYLDGYRKQ-REYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQY
...   .  . . |.|. |.  . . || || |  |. . |..|.|. ||..    ||||| .| ..  ||||.||||.||||| .|.  | |  .| .|
iaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaey

WPSS----GSQNYGVIHVNMMSTVELSDYTIRSFGVKRSGSPEERMVLQYHYtAWPDHGVPNSVTSVLNF
.|..    . . || | | .        | | .. .||    | | .  | |  |.. .|| . ....  
lPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliam
DSPc_SM00195 35-278 7.5e-90 296.2 In-house 17-262 (263) alignment 
Range on Protein: 35-278
Range on HMM: 17-262/263.0
TSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANYLDGYRKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWP
.....  ..|. ||||.||  .|| || |...|....||||||||..|..|...|||.|||||.|..||||||||.....|||.|..||.|..||..|||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

SS--GSQNYGVIHVNMMSTVELS-DYTIRSFGVKRSGSPEERMVLQYHYTAWPDHGVPNSVTSVLNFVRKSSAVNLTEdYGPMVVHCSAGVGRTGTYVVI
..  |....| |.|..... . . ....| . ..  |  |.| | ||.|..|||||||.| .|||...|.    . |.  ||.|||||||||||||.|.|
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvti

DAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAI
|  |.....| .||. . | .|| ||  ||| ..||  |....||.|
diilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 35-278 7.5e-90 296.2 In-house 17-262 (263) alignment 
Range on Protein: 35-278
Range on HMM: 17-262/263.0
TSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANYLDGYRKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWP
.....  ..|. ||||.||  .|| || |...|....||||||||..|..|...|||.|||||.|..||||||||.....|||.|..||.|..||..|||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

SS--GSQNYGVIHVNMMSTVELS-DYTIRSFGVKRSGSPEERMVLQYHYTAWPDHGVPNSVTSVLNFVRKSSAVNLTEdYGPMVVHCSAGVGRTGTYVVI
..  |....| |.|..... . . ....| . ..  |  |.| | ||.|..|||||||.| .|||...|.    . |.  ||.|||||||||||||.|.|
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvti

DAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAI
|  |.....| .||. . | .|| ||  ||| ..||  |....||.|
diilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPN13_pd Subfamily PTPN13 35-278 4.9e-72 237.5 In-house 28-269 (273) alignment 
Range on Protein: 35-278
Range on HMM: 28-269/273.0
TSHHSLNQANRFKNRYNNITAFDHCRVLLQPIEGdptsdYINANYLDGY--RKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQY
|.. . ...|. |||| |.  .|. || |.   |     ||||...      .. ||||.|||||||..|||.|||||...||.|||.  |.|..|||.|
tcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchry

WPSSGSQNYGV---IHVNMMSTVELSDYTIRSFGVKRSGSPEERMVLQYHYTAWPDHGVPNSVTSVLNFVRKSSAvnLTEDYGPMVVHCSAGVGRTGTYV
||.| ...  |   ..|... ...|.....|.. || | | | | | . ....|||||||.| ...|.||..     | .| ||.|||||||.||.||..
wPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrr..lqtdagPivvhcsaGiGrsGtli

VIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAI
.||. |  |. .  .|| . |  || ||. .|| .|||.... ..||..
tidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_PTPN23_pd Subfamily PTPN23 35-277 8.9e-57 187.1 In-house 32-279 (288) alignment 
Range on Protein: 35-277
Range on HMM: 32-279/288.0
TSHHSLNQA--NRFKNRYNNITAFDHCRVLLQpiegDPTSDYINANYLDGYRK-QREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQ
. ..|.  |  .  |||...|  .|| || |.    . . ||||| .. .      ..||.|.||..|  |||.||.|| |.||||... ||.|. |...
arkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdr

YWPSSG--SQNYGVIHVNMMSTVELSDYTIRSFGVKRSGSPEERMVLQYHYTAWPDHGVPNSVTSVLNFVRKSSA---VNLTEDYGPMVVHCSAGVGRTG
|||..   ....| ..| . |. |.. .  | . ..  .. . ..|   ..|.||..|||.|  ..|.|. .  .    .  .   |.||||||||||||
YwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtg

TYVVIDAQLKRIQAEAT-VDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEA
.. .. | .. ....   .|. . |  || ||  ||| ..|.    .. |||
vfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 35-276 3.9e-39 129.1 In-house 43-287 (305) alignment 
Range on Protein: 35-276
Range on HMM: 43-287/305.0
TSHHSLNQ---ANRFKNRYNNITAFDHCRVLLQpieGDPTSDYINANYLDGY-RKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCH
      ||    .  ||||... . |.  |.|.     . |||| |||.      .. .|.||||| .|  .|| || ...   |||. .  | |..|| 
qvafnanqsadiaitknryqdvpcqdqsavkld...kpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkca

QYWPSSGSQN----YGVIHVNMMSTVEL-SDYTIRSFGVKRSGSPEERM-VLQYHYTAWPDHGVPNSVTSVLNFVrksSAVNltEDYGPMVVHCSAGVGR
|||| .  ..     |..  |.  .  .  |  |.   .. . | ...| | . ..| ||| |||    . |...   ||.       |.|||||||.||
qywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslell...sair..gskvpivvhcsagigr

TGTYVVIDAQLKRIQAEAT-VDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLE
||| | |.  |..|  .     . . |  || ||   .| . ||. || |.|.
tgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln
subfamily_PTPN1_pd Subfamily PTPN1 37-286 9e-68 223.1 In-house 25-281 (290) alignment 
Range on Protein: 37-286
Range on HMM: 25-281/290.0
HHSLNQANRFKNRYNNITAFDHCRVLLQPIEGdptsDYINANYLDGYRKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPSS
... ...|| .||| ... .||.|. |.  .     |||||. ..  . .|.|| .|||||.|.  ||.|||||.|. .||. .. |...|||.||||. 
reaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqg

GSQNYG-----VIHVNMMSTVELSDYTIRSFGVKRSGSPEERMVLQYHYTAWPDHGVPNSVTSVLNFVRKS-SAVNLTEDYGPMVVHCSAGVGRTGTYVV
 ...        ..|...|. . | ||.| . ..   . | | .|..|||.||| |||.| .. |.|. |  ..  |..|.|| |.|||||.||.||...
eeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfcl

IDAQLKRIQAEAT---VDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAIA--CGDTEIQ
.|. | .|...     ||. . .. || .|  ..|  ||  . .  .|| .    ||. .|
vdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssvq
0040439 (Phosphotyrosine protein) phosphatases II 38-278 3e-86 284.3 In-house 5-246 (249) alignment 
Range on Protein: 38-278
Range on HMM: 5-246/249.0
HSLNQANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANYLDGYRKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPSSG
..| ..|. |||| .| ..||.|| |....| . ||||||.|.|||. .|..||.|||||||..|||||.||....||||.|...|.||.||.||||..|
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplgg

SQNYGVIHVNMMSTVELSDYTIRSFGVKRSGSPEERMVLQYHYTAWPDHGVPNSVTSVLNFVRKSSAVNLTE-DYGPMVVHCSAGVGRTGTYVVIDAQLK
|..|| ..|...|. ...|||.| . ..... .|.|.||...|| ||||||| |. ..|.|...   .. .  . ||..||||||||||||.....  | 
sleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmle

RIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAI
... | .||....| .|| ||. .|| ..||. ....||| .
qlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0037934 (Phosphotyrosine protein) phosphatases II 38-276 2e-77 255.3 In-house 4-240 (243) alignment 
Range on Protein: 38-276
Range on HMM: 4-240/243.0
HSLNQANRFKNRYNNITAFDHCRVLLqpiegDPtSDYINANYLDGYRKqreYIAAQGPLPETCHD----FWRMVWEQNSRVIVMVTNCEERGRIKCHQYW
..| ..|. |||| .| ..|| || |     .. |||||||. .....   .|| |||||||..|    ||||.||....||||.|...|.||.||.|||
iallpenlsknrysdilpydhsrvkl.....eg.sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PssGSQNYGVIHVNMMSTVELSDYTIRSFGVKRSG-SPEERMVLQYHYTAWPDHGVPNSVTSVLNFVRKSSAVNLT-------EDYGPMVVHCSAGVGRT
|  |...|| ..|...|. .|.|||.| . ... . ....|.| .|||..|||||||.|....|.|...  ..           . ||..||||||||||
p..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRt

GTYVVIDAQLKRIqaeaTVDVYNYVMMLRGQRNL-MVQVEDQYVLIHDVLLE
||.....  |...    .||....| .|| ||.  .|| ..||. ....|||
Gtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 38-274 1.8e-54 179.5 In-house 32-273 (287) alignment 
Range on Protein: 38-274
Range on HMM: 32-273/287.0
HSLNQANRFKNRYNNITAFDHCRVLLQpIEGDPTSDYINANYLDGYRKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPSSG
 . . |.  |||| ..  .|. ||||   ||.  ||||||||. .|... ..||||||.. |  ||||.|.|..| .....|   | .| ||..|||   
aaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPere

S-QNYGVIHVNMMS-TVELSDYTIRSFGVKRSGSPEERMVLQYHYTAWPDHGVPNSVTSVLNFVRKS----SAVNLTEDYGPMVVHCSAGVGRTGTYVVI
     |   | ... ..   .|..|.. .    . | |.| |... .|||.... .  ... || .      .   ... ||.|||...|.||.|... .
vPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillat

DAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVL
 . ..| .    ||| . |. || .|. .||   |. |. . |
lvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyeal
0042113 (Phosphotyrosine protein) phosphatases II 39-277 1.2e-84 278.9 In-house 4-242 (245) alignment 
Range on Protein: 39-277
Range on HMM: 4-242/245.0
SLNQANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANYLDGYRKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPSSGS
.| ..|. |||| .| ..||.|| |.|..||. ||||||.| ||||  . .||.|||||||..|||||.||.....|||.|..||.||.||.||||...|
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplges

QNYGVIHVNMMSTVELSDYTIRSFGVKRSGSPEERMVLQYHYTAWPDHGVPNSVTSVLNFVRKSSAVNLTEDYGPMVVHCSAGVGRTGTYVVIDAQLKRI
..|| ..|...|.  |.|||.| . |.. |..|.|.|..|||. |||||||... ..|.|..    .    . ||..||||||||||||.....  | ..
ltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleql

QAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEA
..| .|.... | .|| ||  .|| ..||. ....||| 
ekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 39-275 3.2e-20 66.7 In-house 46-282 (302) alignment 
Range on Protein: 39-275
Range on HMM: 46-282/302.0
SLNQANRFKNRYNNITAFDHCRVLLQpiegDPTSDYINANYLDGYRKQREYIAAQGPLPETC---HDFWRMVWEQNSRVIVMVTNCEERGRiKCHQYWP-
.. ..|  ||. ... . |. .| |.        .|.||  ..    .|. | || |  ..     .|||||....   .|..   ||  .   ....| 
kafkknlkknqsedvpildsnlvkle....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpk

-SSGSQNYGVIHVNMMStVELSDYTIRSF--GVKRSGSPEERMVLQYHYTAWPDHGVPNSVTSVLNFVRKSSAVNLTEDyGPMVVHCSAGVGRTGTYVVI
 |   ..|| . ||    || .. .   .   |   |  .  ..  |. | |... || ..... . . |  | .   |  ..|.    |.|| |. .. 
ksgdykeygkmfvNnrk.VekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikad.entvivSknGaGRagafltl

DAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLL
 . ....|... . . . |. .| ||  .|.  .||| .. .||
avaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 39-125 2e-13 44.6 In-house 31-114 (332) alignment 
Range on Protein: 39-125
Range on HMM: 31-114/332.0
SLNqaNRFKNRYNNITAFDHCRVLLQPIEGDptSDYINANYLDGYRKQREYIAAQGPLPE-TCHDFWRMVWEQNSRVIVMVTNCEERG
 ||  |   ||   . .||| || | | .|    |. ||...||| |.  || || |. . | . ||||| |..  .|... . .|. 
fln..nmdmnriphlycfdhsrvelapqdgk..ddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekq
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 41-280 3.7e-91 299.8 In-house 6-244 (250) alignment 
Range on Protein: 41-280
Range on HMM: 6-244/250.0
NQANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANYLDGYRKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIkCHQYWPSSGSQN
. .|. |||| .| |.|..||.|.. .||  |||||| .|.||.... .||.||||..|  ||||||.|..| .|||.|| .| ..  .|||||  ....
kpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaek

YGVIHVNMMSTVELSDYTIRSFGVKRSGSPEERMVLQYHYTAWPDHGVPNSVTSVLNFVRKSSAVNLTEDYGPMVVHCSAGVGRTGTYVVIDAQLKRIQA
|| ..|...|. | .|||.| . . .    .||.| |.|...||| |||.  |.||....|  | .   . .|..|.|||||||.|....||| |.|.. 
yGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkk

EATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAIAC
| .|||.... .|| .|  .|. ..||| .. ..|.|. .
ekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_ptpA1_pd Subfamily ptpA1 41-237 3.7e-43 142.8 In-house 44-255 (418) alignment 
Range on Protein: 41-237
Range on HMM: 44-255/418.0
NQANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANYLDGYRkQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPSS----
.. |  |||| ||   .| || |. |.    ||||||||.||    ...|..|||||.|  ||||||||.  |.|||..   |  |||| .|||      
kkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge

-------GSQNYGVIHVNMMSTVELSDYTIRSFGVKRSGSPEERMVLQYHYTAWPDHGVPNSVTSVLNFV-----RKSSAVNLTEDYGPMVVHCSAGVGR
       | . .|   |...  ..  .  | .  .. .   | | . ||.|  |||| .|.    . ...     |.   .  ..   |..|||||||||
qfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgr

TGTYVVIDAQLKR
|||..     .|.
tgtfctavimmkk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 41-276 7.4e-42 137.9 In-house 33-267 (281) alignment 
Range on Protein: 41-276
Range on HMM: 33-267/281.0
N-QANRFKNRYNNITAFDHCRVLLQP-IEGDPTSDYINANYLDGYRKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPSSGS
|   |  |||| || ..|  || |.  .    ..||| |||.     .| || .|||  ||  |||||.|..|.  |||. .  |  | || .|.|    
nqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnah

--QNYGVIHVNM-MSTVELSDYTIRsfgVKRSGSPEERMVLQYHYTAWPDHGVPNSVTSVLNFVRKSSAVNltedyGPMVVHCSAGVGRTGTYVVIDAQL
   ..  . |.   |||. |  | |   .. |   | |.. .. .  |||  ||.|   .|. .||  |        | |.||||||||.|| . ..  |
cclqfdklsvsyedstvnkslvttr...lnlsyegetrlithwlwkewpdwqvpessevmlkilrkirars.....tppvihcsagvgrsgtlmaveial

KRIQAEATV-DVYNYVMMLRG-QRNLMVQVEDQYVLIHDVLLE
. |..  |. |. . |  ||   |   ||  .||.||  |||.
qsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 41-278 1.9e-29 97.5 In-house 32-270 (285) alignment 
Range on Protein: 41-278
Range on HMM: 32-270/285.0
NQANRFKNRYNNITAFDHCRVLLQPIEgdptSDYINANYLDGY-RKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPSSGS-
 .||   ||| .. . .  ||.|.  .     ||| |...    . |  ||..|||||||  |||.|.....   ..|.    | |  ||  |.|     
yeanpdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

-QNYGVIHVNMMSTVE--LSDYTIRSFGVKRSGS--PEERMVLQYHYTAWPDHGVPNSVTSVLNFVRKSSAVNLTEDygPMVVHCSAGVGRTGTYVVIDA
  ..|   . .    |  ..   . .. |  .     |   . . .   |||.  |.    .... .    ||  |   |..|||||||||| |.| || 
vvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkek..picvhcsagvgrtatfvgidy

QLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAI
   ||  .  ... . |  .|  |   ||   |..... ||.| .
atirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 42-277 4.6e-73 240.3 In-house 5-239 (239) alignment 
Range on Protein: 42-277
Range on HMM: 5-239/239.0
QANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANYLDGYRK-QREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPSSGSQn
. |. |||| || ..|| ||.|. .  || ||||||.||  |    . |||.|| .  .. |||||.|..   ||||.|   |  . ||||||| | |. 
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk.

YGVIHVNMMSTVELSDYTIRSFGVKRSGSPEERMVLQYHYTAWPDHGVPNSVTSVLNFVRKSSAVNLTEdYGPMVVHCSAGVGRTGTYVVIDAQLKRIQA
|  ..| .  |  ..|| ||.| . . |  ||| | |||.| |||.|||.  |.|| . || .  .|     | |.||||||||||...|||| |.. . 
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpg.arpwvihcsagvgrtgaflvidamlrqakk

EATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEA
. |||..|||  .| .|  |||  .|||.||  .|||
qktvdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 42-276 1.6e-72 238.6 In-house 6-239 (239) alignment 
Range on Protein: 42-276
Range on HMM: 6-239/239.0
QANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANYLDGYRK-QREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPSSGSQn
. |. |||| || ..|| ||.|. .  || ||||||.||  |    . |||.|| .  .. |||||.|..   ||||.|   |  . ||||||| | |. 
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk.

YGVIHVNMMSTVELSDYTIRSFGVKRSGSPEERMVLQYHYTAWPDHGVPNSVTSVLNFVRKSSAVNLTEdYGPMVVHCSAGVGRTGTYVVIDAQLKRIQA
|  ..| .  |  ..|| ||.| . . |  ||| | |||.| |||.|||.  |.|| . || .  .|     | |.||||||||||...|||| |.. . 
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpg.arpwvihcsagvgrtgaflvidamlrqakk

EATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLE
. |||..|||  .| .|  |||  .|||.||  .||
qktvdifnyvkairedrphmvqtseqyvfihlavle
0049772 (Phosphotyrosine protein) phosphatases II 42-279 3.9e-45 150.3 In-house 44-281 (314) alignment 
Range on Protein: 42-279
Range on HMM: 44-281/314.0
QANRFKNRYNNITAFDhCRVLLqPIEGDPTSDYINANYLDGYrkqREYIAAQGPLPETCHDF----------WRMV--WEQNSRVIVM------------
 .|| |||| .|  .| .|| | | ..  .||||||.|.||.   . .||.||||..|..||          ||||  ...|.|.|||            
flnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsr

---------VTNCEERGrikchqywP---SSGSQNYGvihvnmmstvelsdytirsfGVKRSGSPEERMVLQYHYTAWPDHGVPnSVTSVLNFVRKSSAV
          ... ..|        .    .  ...                     ..  ...  ||....|... .||...| .   .. |..   ..
LdaAlgKtpllildgng........neptaadlellk....................eelydpelferlgikylripvpDgsap.lledfdeflefieea

nltEDYGPMVVHCSAGVGRTGTYVVIDAQLKRIQAeATVDVYNYVMMLRGqRN---LMVQVEDQYVLIHDVLLEAIA
   .. || .|||.||.|||||.||..  .|. .     .....|.. |   |    ...  .||. |...|||.. 
...dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRp.inpnpgfieqleqyefilealleylk
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 43-276 2.5e-74 244.5 In-house 2-237 (237) alignment 
Range on Protein: 43-276
Range on HMM: 2-237/237.0
ANRFKNRYNNITAFDHCRVLLQPIEGDptSDYINANYLDGYRK-QREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPSSG-SQN
 |. |||| ||.|.||.||.|.   ..  ||||||.||.|.    ..||||||||  .|.|||.|||...  ||||.|   |. ..|||.||||.   . 
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGVIHVNMMSTVELSDYTIRSFGVKRSG-SPEERMVLQYHYTAWPDHGVPNSVTSVLNFVRKSSAVN-LTEDYGPMVVHCSAGVGRTGTYVVIDAQLKRI
|||. | .    |.||||.||. . . .   | |.. ||..|.|||.|||.  ...| | ..    .    . || ..|||||||||| ..|||| |.. 
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

QAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLE
. .  ||.||||  .  .|  ..|..||||.||...||
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 43-276 4.4e-66 217.6 In-house 19-262 (270) alignment 
Range on Protein: 43-276
Range on HMM: 19-262/270.0
ANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINANYLDGYRK-QREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPSSGSQ--
 ..  |||..|    . || |...| |... ||||||. |. . ...||||.|||| | ..||||.||.... |||.|. ||.|| || .|||..  .  
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekv

--NYGVIHVNMMSTVELSDYTIRSFGVKRSGSpEERMVlQYHYTAWPDHGVPNSVT------SVLNFVRKSSAVNLTEDY-GPMVVHCSAGVGRTGTYVV
  ..| |.|  .|..  . | ..   ....|. |.|.|  ..|..|||||||..        ..|. .|.  ...   |  .|..|||||||||||| ..
kledgkikvlalseekeegyiltrlrleekge.errlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlia

IDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLE
.|  .. .. .  ||| . .  || .|  .||  .|| ... ...|
lDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 43-276 1.3e-44 147.0 In-house 53-281 (290) alignment 
Range on Protein: 43-276
Range on HMM: 53-281/290.0
ANR--FKNRYNNITAFDHCRVLLQpiEGDPtSDYINANYLDGYRKqrEYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPSSGSQN
.|    |||| ...  |  ||.|.  .| .  ||. |||..| .    .| .||.| .|  |.|||| ...  .|||. .  | |. ||.||.|    . 
kntefkknrykdvvcndktrvilk..dGyd.GdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGev

--YGVIHVNMM-STVELSDYTIRSFGVKRSGSPEERMVLQYHYTAWPDHGVPNSVTSVLNFVRKssavnLTEDYGPMVVHCSAGVGRTGTYVVIDAQLKR
  .| | |    .. . ..   . . |.   |  | ..  ..  .|||. |..|  ..|  .|      | .  ||.|||||||.|||||.| |.. |. 
ltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlri.....lrkasGpvvvhcsaGiGrtGtfvaievglqi

IQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLE
.     .|. . |  ||  |   |||. ||... ..||.
lldGkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 43-287 3.7e-35 116.0 In-house 51-298 (310) alignment 
Range on Protein: 43-287
Range on HMM: 51-298/310.0
ANRFKNRYNNITAFDHCRVLLQpIEGDPTSDYINANYLDGYRKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPSSGS-QNY
 .  |||| ..   | .|| |. |.     ||| |||.     .  .| .||||  |  |||||.... .  |... .  | || ||  |||| |  . |
kymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtety

GVIHVNMMST----VELSDYTIR--SFGVKRSGSP---EERMVLQYHYTAWPDHGVPNSVTSVLNfVRKSSAVnlteDYGPMVVHCSAGVGRTGTYVVID
|.| |  .|      |. . ..      |     |   .|  |   ..  ||| |||.     .   |  . |     .|| |||||||..|... | ..
gcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp.qrllaqv....rhgpcvvhcsagkdrlyvvvalk

AQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLeAIACGDTEIQA
 ......    ||. . .  |. .|   .| | ||..|. | . ..| |.||.  
lkidkldrglkvdaeevktellksraiciqtelqyliidrvri.ifargetevae
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 43-200 4.4e-35 116.0 In-house 32-191 (297) alignment 
Range on Protein: 43-200
Range on HMM: 32-191/297.0
ANRFKNRYNNITAFDHCRVLLQpiEGDPTSDYINANYLDG--YRKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPSS--GS
.   ||||..| |.|  || |.   . . .|||||.|.      ..  || ||||| .| .|||..|.||. ||||||.. .| || ||  ||||.  . 
sslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqer

QNYGVIHVNMMSTVELSDYTIRSFGVKRSGSPEERMVLQYHYTAWPDHGVPNSVTSVLNFVR
.. | . |. .|..     ..    ..     |.|.|    . .|||||||. .  .  |  
lkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqa
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 43-294 1.3e-34 114.5 In-house 42-286 (288) alignment 
Range on Protein: 43-294
Range on HMM: 42-286/288.0
ANRFKNRYNNITAFDHCRVLLQpiegDPTSDYINANYLDGYRKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPSSGSQNYG
||  ..||.|.   | .|| |.    | .  ||.|| .   . .|  | || ||  |   .|.|. |.. . |||...  |.|. |  .|.||   ..  
anptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

VIHVNMMSTVELS--DYTIRSFGVKRSGSPEERM-VLQYHYTAWPDHGVPNSVTSVLNFVRKSsavnlTEDYGPMVVHCSAGVGRTGTYVVIDAQLKRIQ
. ..  .  .. .  | ...   .. |   ||.. | . |.  |.|.|||..  | |...         .   |.|||.||||||||| ..|   |. ..
igrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililialeslr

AEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAIACGDTEiQARDLRQRI
 .  . . . .  || .|   .|.| ||. .| ..|| ..    . . |... ..
lddflgirsllaklreerfkaiqtemqylyvhrcvleelllkkyk.vlredfvkl
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 43-125 9.6e-09 28.4 In-house 26-81 (169) alignment 
Range on Protein: 43-125
Range on HMM: 26-81/169.0
ANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINAnyldgyrkqreyiaaqgplpetchdfwRMVWEQNSRVIVMVTNCEERG
.|  |||     |  | || || .  |  ||||||                           ||.|| |. |||.. ..... 
cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddkn
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 43-125 1.2e-08 28.0 In-house 25-80 (169) alignment 
Range on Protein: 43-125
Range on HMM: 25-80/169.0
ANRFKNRYNNITAFDHCRVLLQPIEGDPTSDYINAnyldgyrkqreyiaaqgplpetchdfwRMVWEQNSRVIVMVTNCEERG
.|  |||     |  | || || .  |  ||||||                           ||.|| |. |||.. ..... 
cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddkn
Y_phosphatase Protein-tyrosine phosphatase 44-276 1.6e-85 281.6 Pfam-A 1-235 (235) alignment 
Range on Protein: 44-276
Range on HMM: 1-235/235.0
NRFKNRYNNITAFDHCRVLLqpiEGDPT-SDYINANYLDGYRKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWP--SSGSQN
|. ||||..|...|. || |   .|... ||||||||..||......||.||||..|..|||||||.....||||.|..||.|| ||.||||  ...|..
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGVIHVNMM-STV-ELSDYTIRSFGVKRSGSP-EERMVLQYHYTAWPDHGVPNSVTSVLNFVRKSSAVNlTEDYGPMVVHCSAGVGRTGTYVVIDAQLKR
|| |.|... ..  . ..||.| . .| .... |.|.| |.|||.|||||||.|..|.|...||    . ... ||.|||||||||||||.|..|. |..
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleq

IQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLE
..|| .|||...| .|| ||. ||| ..||. .....||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 44-276 1.6e-85 281.6 In-house 1-235 (235) alignment 
Range on Protein: 44-276
Range on HMM: 1-235/235.0
NRFKNRYNNITAFDHCRVLLqpiEGDPT-SDYINANYLDGYRKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWP--SSGSQN
|. ||||..|...|. || |   .|... ||||||||..||......||.||||..|..|||||||.....||||.|..||.|| ||.||||  ...|..
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGVIHVNMM-STV-ELSDYTIRSFGVKRSGSP-EERMVLQYHYTAWPDHGVPNSVTSVLNFVRKSSAVNlTEDYGPMVVHCSAGVGRTGTYVVIDAQLKR
|| |.|... ..  . ..||.| . .| .... |.|.| |.|||.|||||||.|..|.|...||    . ... ||.|||||||||||||.|..|. |..
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleq

IQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLE
..|| .|||...| .|| ||. ||| ..||. .....||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 44-276 1e-72 239.6 In-house 28-266 (274) alignment 
Range on Protein: 44-276
Range on HMM: 28-266/274.0
NRFKNRYNNITAFDHCRVLLQPIEG-DPTSDYINANYLDGYRKQ-REYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPSSGS---
.  ||||..|   .. ||||.. .. |. |.||||||. ||... . |.|.|||||.| .|||||.......||||.|. .|. . ||..|.| . .   
sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyei

-QNYGVIHVNMMSTVELSDYTIRSFGVKRSGSpeERMVLQYHYTAWPDHGVPNSVTSVLNFVRKSSAV--NLTEDYGPMVVHCSAGVGRTGTYVVIDAQL
 ..|| ..... ..||  ||..|.. .| . .  || |  | ||.|||| .|......|..|.. .    . ..  .|.|||||||.|||| .. |.  .
serygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiav

KRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLE
.....| .||| . |  || .|  ||| ..|| ||| .| .
rqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
0041856 (Phosphotyrosine protein) phosphatases II 44-283 1.8e-53 176.2 In-house 1-176 (182) alignment 
Range on Protein: 44-283
Range on HMM: 1-176/182.0
NRFKNRYNNITAFDHCRvllqpiegdpTSDYINANYLDGYRKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTnceergrikCHQYWPssgsqnygv
|. |||| .|  .|| |           .||||||...|.......||.||||..|. ||.||..|.. ..||..|         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

ihvnmmstvelsdytirsfgvkrsgSPEERMVLQYHYTAWPDHGVPNsVTSVLNFVRKSSAvnlteDYGPMVVHCSAGVGRTGTYVVIDAQLKRiqaeaT
                         . .||...||.|. |||||||. . ..|.|...  .     . || .||||||||||||.|...  .|.      
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl.....g

VDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAIACGDT
|.... | ..| .|. ||. ..||......||| . ...|
vsleeavklvrsrRpgmvitpnqyfflqlallellllkkt
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 44-282 9.9e-16 52.7 In-house 19-264 (290) alignment 
Range on Protein: 44-282
Range on HMM: 19-264/290.0
NRFKNRYNnITAFDHCRVLLQPIEGDPTSDYINANYLDgYRKQREYIAAQGPLPET-------CHDFWRMVWEQNSRVIVMVTNCEERGRI----KCHQY
.  ..|.. .. . . || |.      ..||| ||..  . .  . |. | |. ..         .|| |. . ... .||. . ||. .      | .|
hemdqRle.vpLveatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakY

WPSSGS--QNYGVIHVNMMSTVELSDYTIRSFGVKRSGSpEERMVLQYHYTAWPDHGVPNSVTSVLNFVRKssaVNltEDYGPMVVHCSAGVGRTGTYVV
 | |     ... . |.  | ..  |  .|   ||  .  ||  |  . .  | .  |...  ..|. ..|   |.      |..|||  |. |  .   
vpesvgeelkfkgltvkCkskekeddvetRelvvkfdde.eeftvtHsllkgWnklnvqedtktllsliqk...vk..asktpvivHcvdGiSrsAalaa

IDAQLKRIQ-AEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHD-VLLEAIACGD
|.     |   .  | . . . .|| ||.|... . ..  .   ..| ||  .|
iilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaievld
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 46-168 1.5e-26 88.0 In-house 49-186 (350) alignment 
Range on Protein: 46-168
Range on HMM: 49-186/350.0
FKNRYNNITAFDHCRVLLQ----PIE----GDPTSDYINANYLDGY----RKQR--EYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQ
 ||||.||  ..| || |.    . .       |.||||||||       . .    |||.|.|||.| .||.... . . .||...|.  | .. ||..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPSSGSQNYGVIHVNM-MSTVELSDYTIRSFGVKRSG
||.  . ... |   ..  ....  | ...|..||.  
YWqegsydditvklaskwenimgindsslysadvkkea
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 47-279 3.3e-30 99.9 In-house 46-277 (312) alignment 
Range on Protein: 47-279
Range on HMM: 46-277/312.0
KNRYNNITAFDHCRVLLQpieGDPtSDYINANYLDGYRKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPS-SGSQNYGVI-
 ||| ||  .|  |  |    ||    || ||..    |   ....|||| .||  ||...    |  |....   | |  || .|     |  .     
lnrypniqcwdrgrftla...gde.nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhr

-HVNMMSTVELS-----DYTIRSFGVKRSGSPEERMVLQYHYTAWPDHGVPNSVTSVLnfvRKSSAVNltEDYGPMVVHCSAGVGRTGTYVVIDAQLKRI
 . .. . .|.        | | . |    . .|  . .| ...|||||.|.|. . |   |  |||.   |  |.. ||||||||||| ..|.. .  .
vyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtal...rllsavk..kdkkpviahcsagvgrtgtlaliesmiaal

QAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAIA
.     .| .  ..|| .|   |.|  |||    ..|| . 
rhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefly
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 47-153 1.4e-16 54.7 In-house 51-170 (349) alignment 
Range on Protein: 47-153
Range on HMM: 51-170/349.0
KNRYNNITAFDHCRVLLQP----IEG----------DPTSDYINANYLDGYR--KQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCH
||||..|  ..| || |.      ..              ||||||||   |   .. ||| | ||| | .||....  .. .... ... .| .  ||.
knrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcd

QYWPSsgsQNYGVIHVNMMSTVE
.||      .|  |.| .  . .
iywqe...lsysnitvklqnssl
subfamily_eak_pd Subfamily eak 51-190 1.7e-12 41.4 In-house 58-196 (332) alignment 
Range on Protein: 51-190
Range on HMM: 58-196/332.0
NNITAFDHCRVLLQPIEGDPTsDYINANYLDGYRKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPSSG--SQNYGVIHVNM
 .|  .|.  | | .   ..   ||||  ..     |.|| .  .  .    ||.|| ||.|  ||.. .  | .  |  .|.|  .    ..|...|. 
vkivpydrylvrltssqlnrl.GyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildver

MSTVELSDYTIRSFGVKRsGsPEERMVLQYHYTAWPDHGVPN
 . |. . .  | . ... |  |   || |..  | .  .| 
kefvkrniletrllelsk.G.nethrvlhykvfGwtettlpk
0044763 (Phosphotyrosine protein) phosphatases II 56-276 1.3e-36 121.3 In-house 2-169 (178) alignment 
Range on Protein: 56-276
Range on HMM: 2-169/178.0
FDHCRVLLQPIEGDPTSDYINANYLDGYrkqrEYIAAQGPlpetcHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPSSGSqnygvihvnmmstvels
.|..||||...|| ..||||||.. ...     |.....|      |......|.. ..||..|.  |.|..||..|||.. .                 
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

dytirsfgvkrsgspeermvLQYHYTAWPDHGVPNSVTSVLNFVRKSSAVNLTEDyGPMVVHCSAGVGRTGTYVVIDAQLKRiqaeaTVDVYNYVMMLRG
                    .||... .||||||..   .|.||.   ..  ... || .|||||||||.|| |...  .|.      ..... . ..| 
....................iqylhipipDhgvpdllehflefvefieealdekg.gpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvre

QRNlMVQVEDQYVLIHDVLLE
.|. .|. ..|.  .... |.
rRp.ivpnpgqlrqLyefelr
0046846 (Phosphotyrosine protein) phosphatases II 63-276 4.8e-45 148.7 In-house 3-171 (176) alignment 
Range on Protein: 63-276
Range on HMM: 3-171/176.0
LQPIEGDPTSDYINANYLDGYRkqreYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPSSGSQNYgvihvnmmstvelsdytirsf
|...  |. .||||||...|.|    .|| |||||.|. ||..|..|.. ...|..|.. | ||.||..|||   . ..                     
lrllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.....................

gvkrsgspeermvlQYHYTAWPDHGVPNSvTSVLNFVRKSSAVNLTEdyGPMVVHCSAGVGRTGTYVVIDaqlkRIQAEATVDVYNYVMMLRGQRN-LMV
              ||... |||||||.. . .|....    .      || .||||||.|||||.|...     .. |  ..|.. . ..| ||   .|
..............qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgav

QVEDQYVLIHDVLLE
| ..||  .....|.
qtpeQyrflyefell
0043147 (Phosphotyrosine protein) phosphatases II 69-271 8.4e-46 151.2 In-house 2-154 (172) alignment 
Range on Protein: 69-271
Range on HMM: 2-154/172.0
DPTSDYINANYLDGYRKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCeergrikchqywpssgsqnygvihvnmmstvelsdytirsfgvKRSG
|. ||||||.|||.|.. ...|| ||||..|..|||||..|.. ..||..|..                                              .
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydp

SPEERMVLQYHYTAWPDHGVPnSVTSVLNFVRKSSAVNLTEDYGPMVVHCSAGVGRTGTYVVIDAQLkriqaeATVDVYNYVMMLRGQRNLMVQVEDQYV
...||...||.|. ||||||| .   .|.|..    . . .. ||..|||||||||||| |...  |        ..... | ..| .|. .|| ..|| 
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyr

LIH
...
fly
0051429 (Phosphotyrosine protein) phosphatases II 70-293 1.3e-55 184.2 In-house 2-239 (272) alignment 
Range on Protein: 70-293
Range on HMM: 2-239/272.0
PTSDYINANYLDGYRK---QREYIAAQGPLPETCHDFWRMvWEQNSRVIVMVTNCEERGRIKCHQYWP------------SSGSQNYGVIHVNMMSTVEL
|.|.||||....|| .    . .....|||| |..||||. .|.. ..||.....||||| ||..|||            |  . .|| ..| ..|.. |
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

SDYTIRSFGVKRS-GSPEERMVLQYHYTAWPDHGVP-NSVTSVLNFVRKssavnltedYGPMVVHCSAGVGRTGTYVVIDAQLKRIQAEATVD-------
.||..| . ...  .  | |.|...|||.||||||| ... ..|.....          ||..||||||..||||.|...  | .. .|. ||       
ldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld.........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-VYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAiACGDTEIQARDLRQR
 ....| .|| ||  .|| |.||. ....|||. ... ....|. |.. 
yleeaveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaa
0051082 (Phosphotyrosine protein) phosphatases II 71-275 8.3e-36 118.2 In-house 2-150 (151) alignment 
Range on Protein: 71-275
Range on HMM: 2-150/151.0
TSDYINANYLDGYrkqreYIAAQGPLPetchDFWRMVWEQNSRVIVMVTNCEERGriKCHQYWPSSGsqnygvihvnmmstvelsdytirsfgvkrsgsp
 |||||..|..|.     ... .|||.    ||.....|.. ..||.... ||||  .|..|.|. |                                 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

eeRMVLQYHYTAWPDHGVPNSVTSVLNFVRKSSAvnltEDYGPMVVHCSAGVGRTGTYVVIDAQLKRiqaeatVDVYNYVMMLRGQRNLMVQVEDQYVLI
  . ||..... |||.|.| |  .||.|...  .     . ||..||||||.||||| |...  | .      |...  . ..| .|  .|| ..|....
..ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfq

HDVLL
. .||
lfall
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 71-146 2.6e-09 31.5 In-house 12-82 (130) alignment 
Range on Protein: 71-146
Range on HMM: 12-82/130.0
TSDYINANYLDGYRKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERgrikcHQYWPSSGSQNYGVIHV
  .||||...    . .||. .| || .|. |||.|. |.   |.|..   ||       .||| |   ..   ..
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeedi
0036282 (Phosphotyrosine protein) phosphatases II 72-272 1.4e-50 166.7 In-house 2-164 (174) alignment 
Range on Protein: 72-272
Range on HMM: 2-164/174.0
SDYINANYLDGYRKQREYIAAQGPLPetchdFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPSsgsqnygvihvnmmstvelsdytirsfgvkrSGSPE
||||||..||...  ...|| ||||.     ||.|..|......||.....|.|. ||..|||.                                 . .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredl

ERMVLQYHYTAWPDHGVPNSVTsVLNFVRKSSAVNLTEDYGPMVVHCSAGVGRTGTYVVIDAQLKRIQaEATVDVYNYVMMLRGQRNLMVQVEDQYVLIH
||...||.|. |||||||.. . .|.||.    . .  . ||..|||||||||||| |...  |...  | .||....| .|| ||  ||| ..||  ..
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly

D
.
y
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 73-267 1.6e-30 100.9 In-house 76-270 (301) alignment 
Range on Protein: 73-267
Range on HMM: 76-270/301.0
DYINANYLDGYRKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPSSGSQNYGVIH--V--NMMSTVELSDYTIRSFGVKRS-
  | ||...   . . .||.||||..|..||| |.   .   |||...  |.   ||..| |.. |..  .    .  . . ..   . . |.. |. | 
vPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedst

GSPEERMVLQYHYTAWPDHGVPNSVTSVLNFVRkssAvnLTEDYGPMVVHCSAGVGRTGTYVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQY
|  . | |. | |. |.|.|||.| . . ...       . .   |.|||||||.||. ...  .   ....|. |... . .  || .|   || . | 
gkfatrtvthyqysewtdrgvPkshaelfdlme...l..vkksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsql
0049260 (Phosphotyrosine protein) phosphatases II 79-272 2.3e-42 139.6 In-house 1-144 (152) alignment 
Range on Protein: 79-272
Range on HMM: 1-144/152.0
YLDGYRKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWpssgsqnygvihvnmmstvelsdytirsfgvkrsgspeermvlQY
..|||....|.||.|||.|.|. |||||..|.. ..|||.|...|.|..||.||.                                           ||
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

HYTAWPDHGVPNSVTSVLNFVRKSSAVnLTEDYGPMVVHCSAGVGRTGTYVVIDAQLkriqaeATVDVYNYVMMLRGQRNLMVQVEDQYVLIHD
... |||||||..   .| ...      . .. || .||||||||||||.|...  |        |.....| ..| .|. .|. ..|. ....
lhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 81-270 2.6e-18 60.5 In-house 84-280 (302) alignment 
Range on Protein: 81-270
Range on HMM: 84-280/302.0
DGYRKQREYI-AAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPSS--GSQNYGVIHVNMMST-VELSD---------YTIRSFGvKRS
||  |...       |  .|.  .| .. . |  ..| ...  | .  || .|.     |  ..|   |. .|   .|..         ||.     .. 
dGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveikn.ekk

GSPEERMVLQYHYTAWPDHGVPNSVTSVLNFVRkssavnLTEDYG-PMVVHCSAGVGRTGTYVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQ
 .  .. |   ...|||||| |.   . |. ..        | |   ..|||||||||||| | |   ..  . . . |. . |. .|  |   || |.|
kkkvkktvdilafsawpdhGapkeaytaldilk......fcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqq

YVLI
 . .
liyl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 81-147 3.2e-08 27.3 In-house 230-294 (440) alignment 
Range on Protein: 81-147
Range on HMM: 230-294/440.0
DGYRKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERgriKCHQYWPSS-GSQNYGVIHVN
.|| |.  .||.| ||  |  ||||.| . .   |.|. . ...    |  |||    |  .| . | 
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvg
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 84-272 5.1e-27 89.3 In-house 2-198 (199) alignment 
Range on Protein: 84-272
Range on HMM: 2-198/199.0
RKQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPS--SGSQNYGVIHVNMMSTVELSDYTIRSFGVK--RSGSPEERMVLQYH
. || |||.| || ||  |||.||||  |  |||| . .         |||.  ||. .|| . |   . .  .|||| .. .    .  |  | . .| 
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

YTAWPDHGVPNsVTSVLNFVRKSSAV---NLTEDYGPMVVHCSAGVGRTGTYVVIDAQLKRIQAE--ATVDVYNYVMMLRGQRNLMVQVEDQYVLIHD
.|.| ..  || |.  . ||  |  |      |   |..|||| | | || .| .|  ..  .    . ||...    ||  |  ..   ..| .|..
ftswkekttpn.valfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 85-272 6.7e-27 88.9 In-house 2-197 (198) alignment 
Range on Protein: 85-272
Range on HMM: 2-197/198.0
KQREYIAAQGPLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPS--SGSQNYGVIHVNMMSTVELSDYTIRSFGVK--RSGSPEERMVLQYHY
 || |||.| || ||  |||.||||  |  |||| . .         |||.  ||. .|| . |   . .  .|||| .. .    .  |  | . .| .
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

TAWPDHGVPNsVTSVLNFVRKSSAV---NLTEDYGPMVVHCSAGVGRTGTYVVIDAQLKRIQAE--ATVDVYNYVMMLRGQRNLMVQVEDQYVLIHD
|.| ..  || |.  . ||  |  |      |   |..|||| | | || .| .|  ..  .    . ||...    ||  |  ..   ..| .|..
tswkekttpn.valfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 90-257 4.2e-19 63.6 In-house 39-197 (255) alignment 
Range on Protein: 90-257
Range on HMM: 39-197/255.0
IaaqgplpeTCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPSSGSQNYGVIHVNMMSTVELSDYTIRSFGVKRSGS--PEERMVLQYHYTAWPDHG
.        |   |....  ... |.||... .| |. ||..|.|    .   . .||. .|   .|  .|   .    .   . . |  |.|. |... 
l........tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWiekn

VPNSVTSVLNFVRkssavnLTEDYGPMVVHCSAGVGRTGTYVVIDAQLK----RIQAEATVDVyNYVMMLRGQR
 |.    .|| ..      .  |  ..|||||.|.||. ..|...   .     ..   ||.. .|. .|.  |
aPelareilnilk......vvrdsksvvvhCstGiGrsaafvlaelvyqkmirsldttetvel.dylslleelr
subfamily_hpo-7_pd Subfamily hpo-7 91-258 9.9e-17 55.7 In-house 42-204 (263) alignment 
Range on Protein: 91-258
Range on HMM: 42-204/263.0
AaqgpLPETCHDFWRMVWEQNSRVIVMVTNCEERGRIKCHQYWPSSGSQNYGVIHVNMMSTVELSDYTIRSFGVKRSG--SPEERMVLQYHYTAWPDHGV
     | .| . |....  ... |.||... .| |. || .|.|    .   . .||. .|   ||  ...  .        . . | .| |. |...  
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWieknd

PNSVTSVLNFVRkssavnLTEDYGPMVVHCSAGVGRTGTYVVIDAQLK----RIQAEATVDVyNYVMMLRGQRN
|.   ..|| ..      .. .  ..|||||.|.||.  ..|..   .     ..   ||.. .|. .|.  |.
pelareilnilk......varnskslvvhcstGiGrsaafsvaElvyqkmirsldttstvel.dylsLleelrs
0048179 (Phosphotyrosine protein) phosphatases II 150-272 3.4e-23 77.4 In-house 24-139 (144) alignment 
Range on Protein: 150-272
Range on HMM: 24-139/144.0
STVELSDYTIRSFGVKRSGSPEERMVLQYHYTAWPDHGVPNSVTSVLNFVRKSSAVNLteDYGPMVVHCSAGVGRTGTYVVIDAQLkriqaEATVDVYNY
   .|  .|. ..  ..    .||...||... |||||||.. . .|.|..   ..    . ||..||||||||||||.|...  .     .  ..... 
llkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleea

VMMLRGQRNLMVQVEDQYVLIHD
. ..| .|  .|. ..|.  ...
lalvrsrrpgavpnpgqlrfLle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 152-321 1.9e-31 103.9 In-house 72-237 (440) alignment 
Range on Protein: 152-321
Range on HMM: 72-237/440.0
VELSDYTIRSFgvkRSGsPEERMVLQYHYTAWPDHGVPNSVTSVLNFVRKSSAVNLTEDYGPMVVHCSAGVGRTGTYVVIDAQLKRIQAEATVDVYNYVM
|  |||   |.    .|  | | . |||| .|||.|||. .  ||....  .  .     ||..||||||.||||  ...|. |.  .    .|..... 
vpdsdyinasy...ing.iesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfin

MLRGQRNLMVQVEDQYVLIHDVLLEAIACGDTEIQARDLRQRIKELMRPSTDTGQTEMDAEFQRLSRNKA
 .| .|  |||. .||...|...||.. |||| |   |. .|....  |.  | .. .. ||.  |...|
smrnnrpqmvqtpeqyafvheavlegllcgdtliledditerveqiqwpnphtdksplqqefegyskkna
0048076 (Phosphotyrosine protein) phosphatases II 152-275 1.2e-23 78.8 In-house 23-140 (145) alignment 
Range on Protein: 152-275
Range on HMM: 23-140/145.0
VELSDYTIRS-FGVKRSGSPEERMVLQYHYTAWPDHGVPNSVTSVLNFVRKSSAVNLTEdyGPMVVHCSAGVGRTGTYVVIDAQLKriqaeATVDVYNYV
 .| |. |.  . . .  . .||...||.|. |||||||..   .|.|..   ..   .  ||..||||||||||||.|...  |.       |.... .
ellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleeal

MMLRGQRNLMVQVEDQYVLIHDVLL
 ..| ||  .|. ..|.  .....|
elvrsqrpgavpnpgqlrflyefel
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 164-259 2.5e-06 21.2 In-house 218-319 (347) alignment 
Range on Protein: 164-259
Range on HMM: 218-319/347.0
VKRSGSPEERMVLQYHYTAWPDHGVPNSVTSVLNFVRK----SSA--VNLTEDYGPMVVHCSAGVGRTGTYVVIDAQLKRIQAEATVDVYNYVMMLRGQR
|   |  |  .   |  |.|| .  |. .  || .||     ||.  .   |   |.|| |  |. |. | |.    .... .  | |. .    .| ||
vvaegcseatfakvyncttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiiieqvldgktpdcddlfkkmrdqr

NL
  
ag
PTEN_1 166-227 2e-07 26.0 In-house 85-146 (196) alignment 
Range on Protein: 166-227
Range on HMM: 85-146/196.0
RSGSPEERMVLQYHYTAWPDHGVPNsVTSVLNFVRKSSAVNLTED-YGPMVVHCSAGVGRTGT
.. . .... ..|.   ..|||.|.   ... ....     |  .  .  .||| ||.||.||
ydleeffksgveylhfpieDhgaps.lselfdicksfiewllsdpngnvVlVHCkaGlgRsGt
0038934 (Phosphotyrosine protein) phosphatases II 171-230 2.2e-08 29.4 In-house 75-134 (194) alignment 
Range on Protein: 171-230
Range on HMM: 75-134/194.0
EERMVLQYHYTAWPDHGVPNSVTSVLNFVRKSSAVNLTEDYGPMVVHCSAGVGRTGTYVV
 |.. ..|.   .||.|.. |   .|.|..    ..     |  .||| ||.||||| |.
fekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlva
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 174-275 3.5e-14 47.3 In-house 216-341 (350) alignment 
Range on Protein: 174-275
Range on HMM: 216-341/350.0
MVLQYHYTAWPDHGV---PNSVTSVLN----FVR--KSSAVNLTEDYGPMVVHCSAGVGRTGTYVVIDAQLK------RIQAE--------ATVDV-YNY
.|.| ..  |.| ..   |.|. ..|.    ..    .     ..   |..||||||||||||.| .|  |.       .. |         | |.    
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

VMMLRGQRNLMVQVEDQYVLIHDVLL
|  || ||  |||  ||.. |.. ||
vnelrkqrismvqnldqfifiYeall
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 174-276 1.9e-09 31.3 In-house 219-342 (349) alignment 
Range on Protein: 174-276
Range on HMM: 219-342/349.0
MVLQYHYTAWPDHGV---PNSVTSVLNfVRK-------SSAVNLTEDYGPMVVHCSAGVGRTGTYVVIDAQLK----------RIQAEA-TVDVYN-YVM
..||  .  |.| ..   | |.   |. |..       .     |..  ...|||||| ||||..| .|  |           .|. .| . |.    | 
ellqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivn

MLRGQRNLMVQVEDQYVLIHDVLLE
 || ||  |||   |.. |.. ||.
elrkqrismvqnlaqfiaiyealLk
PTPc_DSPc_SM00012 175-276 2.6e-32 106.5 In-house 2-105 (105) alignment 
Range on Protein: 175-276
Range on HMM: 2-105/105.0
VLQYHYTAWPDHGVPNSVTSVLNFVRKSSAVNLTED-YGPMVVHCSAGVGRTGTYVVIDAQLKRIQAE-ATVDVYNYVMMLRGQRNLMVQVEDQYVLIHD
| .||||.|||||||....|.|...|.   ..  ..  .|.|||||||||||||.|..|  |.....|  .||....| .|| ||. ||| |.||. ...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VLLE
.|||
alle
subfamily_PTPDC1_pd Subfamily PTPDC1 176-272 8.4e-08 26.8 In-house 83-170 (182) alignment 
Range on Protein: 176-272
Range on HMM: 83-170/182.0
LQYHYTAWPDHGVPnSVTSVLNFVRKsSAVNLTEDygPMVVHCSAGVGRTGtyVVIDAQLkrIQAeATVDVYNYVMMLRGQRNLMVQVEDQYVLIHD
. ..  .|.|.||. |....|. |.   |  |.|.   . ||| || ||||  |.| . |  . |   ..  . . ..| .|   .|  .|  |...
iyvynfgwkDygva.sleriLdivkv.vafalqeg..kvavhChaGlGrtG..vliacyl..vya.krltaekaiklvrskrpksiqtreqvelvke
subfamily_CG42327_pd Subfamily CG42327 202-275 8e-16 52.6 In-house 238-312 (319) alignment 
Range on Protein: 202-275
Range on HMM: 238-312/319.0
SSAVNLTEDYGPMVVHCSAGVGRTGTYVVIDAQLKRIQAE-ATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLL
||     |..||.||||| ||||||. .  | ......    .||. . |  .| .|   |.  .|| .|. || 
ssrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvls
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 213-277 7.6e-12 39.7 In-house 230-294 (297) alignment 
Range on Protein: 213-277
Range on HMM: 230-294/297.0
PMVVHCSAGVGRTGTYVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEA
...|||||||||.|  |  |. |.... .   ||   . .|| ||  .||  .|. |..|. |. 
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkk
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 214-281 1.2e-20 67.7 In-house 1-68 (69) alignment 
Range on Protein: 214-281
Range on HMM: 1-68/69.0
MVVHCSAGVGRTGTYVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAIACG
||||||.| |||||.. |  .. ||..|  ||..| |  .|  | .||  | .|..||| | ||.  |
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 215-281 1.3e-19 64.3 In-house 1-67 (69) alignment 
Range on Protein: 215-281
Range on HMM: 1-67/69.0
VVHCSAGVGRTGTYVVIDAQLKRIQAEATVDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAIACG
|||||.| |||||.. |  .. ||..|  ||..| |  .|  | .||  |..|..||| | ||.  |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
subfamily_eak_pd Subfamily eak 215-285 6.6e-06 19.7 In-house 240-312 (332) alignment 
Range on Protein: 215-285
Range on HMM: 240-312/332.0
VVHCSAGVGRTGTYVVIDAQLKRIQAEAT--VDVYNYVMMLRGQRNLMVQVEDQYVLIHDVLLEAIACGDTEI
.. .. |  |.|..||||  .. |..  .    | ....  . .|.  | |. |. .|....|. .   . ..
iiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrl
0050432 (Phosphotyrosine protein) phosphatases II 276-574 2.2e-103 341.1 In-house 10-305 (308) alignment 
Range on Protein: 276-574
Range on HMM: 10-305/308.0
EAIACGDTEIQARDLRQRIKELMR-PSTDTGQTEMDAEFQRLSRNKApPSKFQSANLPVNKHKNRYANVLPYDDTRVRLtmqavTEGSDYINANYIDGY-
|.....||.|.. .|......|..     .. . ...||..| ..|  . .. .|.|| ||.|||| ..|||| .||.|      ||||||||.|.||| 
elllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgys

-MSKKAFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESGKVKVHRYWPGK---QPTSIGNLVVEMLHDKQFDDYIMREFKVTNTKESASRVVRQYQ
  ....|||||.| |.|. |||||.|||.. .|||| ...| |..| ..||| .   ... .|...|..|. ...|||..|....||.... ||.|....
sklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfh

FTAWPDIGSPDSGGGLIDLIGQVQRWQQKcgvQLTAVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYLH
.|.||| | |.|   |.|.. .|......     ..|||||||||||.|.|. .|.|.|..| .||||..||.|||||| ||||.|||.|.|..| |||.
ytnWpdhgvPpspeilldflelvrkslpg...gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk

SFDPY
..  .
lkltk
0051299 (Phosphotyrosine protein) phosphatases II 281-568 7.4e-102 335.9 In-house 1-286 (288) alignment 
Range on Protein: 281-568
Range on HMM: 1-286/288.0
GDTEIQARDLRQRIKELMrpstDTGQTEMDAEFQRLSRNKAPpSKFQSANLPVNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYIDGYMSKKAFI
|||||....|......|.     .|.| . .||..| .....  .. .|.|| |..|||| ..||||..||.|..    ||||||||.||||| .|..||
gdteisveellklvlkll....angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfI

ATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESGKVKVHRYWPGKQPTSIGNLVVEMLHDKQFDDYIMREFKVTNT----KESASRVVRQYQFTAWPDI
|||.| |.|. |||||.|||.. .|||| ...| |..| ..||| .... .|...|..|. ...|||..|...|||.    ... || |.....|.||| 
atqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdh

GSPDSGGGLIDLIGQVQRWQQkCGVQLTAVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYL
| |||   |.|.. .|.....  |   ..|||||||||||.|.|. .|.|.|..| .|||...||.|||||| |||| |||.|.|..| |||
gvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 281-574 1.3e-100 331.5 In-house 1-296 (298) alignment 
Range on Protein: 281-574
Range on HMM: 1-296/298.0
GDTEIQARDLRQRIKELMRPSTDTGQTEMDAEFQRLSRNKA--PPSKFQSANLPVNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYIDGYMSKKA
|.|||.|.||.. ...|   . ... | ...|||||.. .   .  . . |. | ||.|||||.....| .||.|. .   | |||||| ....|  ..|
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

FIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESGKVKVHRYWPGKQPTSIGNLVVEMLHDKQFDDYIMREFKVTNTKESASRVVRQYQFTAWPDIGS
|||||||.. |. |||||..|.|  ||||| .  |..|.|.|.||| .. .  |.. |..|....| |.|.|..||...||. .| ||| .|| ||| | 
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgv

PDSGGGLIDLIGQVQRWQQKCGVQLTAVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYLHSFDPY
|     ..||. .|...||..| .   |.|||||||.| |.|.. ..||.|.| .|||||.|| ||..||..|||.||| |.|.   |.|.||. .
penatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnde
subfamily_PTPN6_pd Subfamily PTPN6 283-570 8.9e-84 276.1 In-house 2-299 (306) alignment 
Range on Protein: 283-570
Range on HMM: 2-299/306.0
TEIQARDLRQRIKELMRPSTDTGQTEMDAEFQRLSRNKAPP-SKFQSANLPVNKHKNRYANVLPYDDTRVRLTmQAVTEGSDYINANYIDGYM--SKKAF
|.. |....||..|| . ....... .  ||..|....|    . . .. | ||.|||| |.||.|.||| |. .  . ||||||||||.. .  |.|..
tsllakeieqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksy

IATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESGKVKVHRYWPGKQ-PTSIGNLVVEMLHDKQFDDYIMREFKVT-NTKESASRVVRQYQFTAWPDIG
||||  ...|..|||||.|....  |||. .|.| || |  |||| ..  .. |.. |.....|. .|||.||..|. ..|.. .| |.||.|..||| |
iatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhg

SPDSGGGLIDLIGQVQRWQQKCG---VQLTAVHCSAGVGRTGVFCAVSILIERLK---AEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYLHS
 | . | ..|.. .|.| |...       . ||||||.|||| |  . ||.. ..    .| .|. ..||..||||  .|||..|| | |... .|...
vpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_PTPRB_pd Subfamily PTPRB 285-569 1.2e-91 301.8 In-house 7-286 (293) alignment 
Range on Protein: 285-569
Range on HMM: 7-286/293.0
IQARDLRQRIKELMRPStdtgQTEMDAEFQRLSRNKAPpSKFQSANLPVNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYIDGYMSKKAFIATQA
|..... . .|.. . |    ....  |...|.  .    . ..|.|.||. |||| |.|||| .||.|.  . ..||||||||||.|| |.. ||||| 
iklekfeehvkkmkads....dlrfseeyeelkavgkd.qavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqG

PIPDTIPDFWRMIWEQDCCTIVMLSQEMESGKVKVHRYWPGK-QPTSIGNLVVEMLHDKQFDDYIMREFKVTNtkESASRVVRQYQFTAWPDIGSPDSGG
|.|.|. |||||.||. . .|||| | .| |||| ..||| . .|.  |.. |....... .|...||.|...  |...| ||||.||.||| | |..  
PlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektk

GLIDLIGQVQRWQ-QKCGVQLTAVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYLH
 |.|.. .|.... ...  . . |||||||||||.| |.  |..... | .||.| .| .|||.|  .|||..|| | .|.. ..|.
tlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 285-567 4.1e-85 280.9 In-house 11-291 (319) alignment 
Range on Protein: 285-567
Range on HMM: 11-291/319.0
IQARDLRQRIKEL-MRPSTDTGQTEMDAEFQRLSRNKAPPSKFQSANLPVNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYIDGYMSKKAFIATQ
.  .|..   ..|  .   |  .|.. .||.|...  .. .. . |||. || |||. |.|..| ..|.|      |.|||||| ...|| .|. .||.|
vavpdfpayyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaq

APIPDTIPDFWRMIWEQDCCTIVMLSqemesgKVKVHRYWPGKQPTSIGNLVVEMLHDKQFDDYIMREFKVTN-TKESASRVVRQYQFTAWPDIGSPDSG
 | ..|. ||||||||..|.|||.|.      | |  .||| |     ..  |..   .. ..|..|...... .||   | ..|. |  ||| | ||..
GPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdyp

GGLIDLIGQVQRWQQKCG-VQLTAVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGE-Y
  |. |. .|.  ..|    .   ||||||||||||. .. .|..|.| | .|||...|..||.||. .||   || |.| .| | .
sdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 291-568 2.9e-35 116.5 In-house 6-287 (305) alignment 
Range on Protein: 291-568
Range on HMM: 6-287/305.0
RQRIKELMRPSTDTGQTEMDAEFQRLSRNKApPSKFQSANLPVNKHKNRYANVLPYDDTRVRLtmqAVTEGSDYINANYIDGYMSKKAFIATQAPIPDTI
...| .... . . | . . |||. . | .    |...     ...|||| .|   |. ||.|     .   .|| |||.      | || ||||. .| 
kkqilkfvkrtlekgpaglraefvamkrfnd.fekmkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektc

PDFWRMIWEQDCCTIVMLSQEMESGKVKVHRYWPGKQPTSIG------NLVVEMLHDKQFDDYIMREFKVTNT------KESASRVVRQYQFTAWPDIGS
 ||| | ...   .| || . .| |  | . |.. |.   .        ..| .   ....     . |||.|        . .| | .| .  ||| | 
adfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgv

PDSGGGLIDLIGQVQRwqQKCGvqlTAVHCSAGVGRTGVFCAVSILIERLKAEAMVDVF-QTVKQLREQRPAMVQTKEQYEFCYQTLGEYL
| .   ...|. . .    |     ..||||||.||||    .  ....| |  ...   . ....||||   .|| .|| | .| . .|.
paadlailellekarp..skgp...ivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
subfamily_PTPN9_pd Subfamily PTPN9 293-568 3.2e-87 287.3 In-house 2-290 (297) alignment 
Range on Protein: 293-568
Range on HMM: 2-290/297.0
RIKELMRPSTDTGQTEMDAEFQRLsRNKAPPSKFQSANLPVNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPD
.|.||.    ..|.  .  |.. . ||...  .|. ..|..| .||||..|| ||.||| |. .  .| |||||||..|||  |||||||| |.. |. |
eieelvayvkekgkrGlskeyaei.rnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsd

FWRMIWEQDCCTIVMLSQEMESGKVKVHRYWPGKQP--TSIGNLVVEMLHDKQFDDYIMREFKVTNTKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIG
||||.|||.. .|||  . .| |..|  .||| ..   .. |.| |. ..... .|| .| ....|.|.. || |  .||..||| | |.|.  |.|.. 
fWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvle

QVQRWQQKCGVQLT------------AVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYL
.|.. | .   .|.             ||||||.|||| |... | ..||. ...|||..|||.||.||  ..|| |||||||... || 
kvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 294-577 5.7e-77 253.5 In-house 7-287 (287) alignment 
Range on Protein: 294-577
Range on HMM: 7-287/287.0
IKELMRPSTDTGQTEMDAEFQRLSRNKAPPSKFQSANLPVNKHKNRYANVLPYDDTRVRLTmqavTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDF
. |...  ...|...    |. | . .  . .   .  . ||.|||....|..|. || |      |  ||||| .|||| .|||||....|. .|. .|
fgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnf

WRMIWEQDCCTIVMLSQEMESGKVKVHRYWPGKQPTSIGNLVVEMLHDKQFDDYIMREFKVTNTK-ESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQV
|..|...   .||||.||.|. . . ..||| .. ...|.  .|.|.... ..||.|...|.|.. ... . |.|||.|.|.. |   .    . .| . 
WkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieem

QRWQQKCGVQLTAVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYLHSFDPYNNF
 . |.| |     ||||..|||...|||. . |.. | |  .|||| .|. | |.| .||| |||.| .. . |||.||. | .|
yktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 300-568 4.6e-43 142.4 In-house 9-277 (307) alignment 
Range on Protein: 300-568
Range on HMM: 9-277/307.0
PSTDTGQTEMDAEFQRLSRNKapPSKFQSANLPVNKHKNRYANVLPYDDTRVRLTMQAVTegSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWE
 . | | ...  ||. |.. .  |   .   .  | .|||| .|   | .|. .... ..  |||| |||.   .  | ||..| |  .|. .|| |. .
rtldkgvqalvdefrvlakkt..pegvtveafsantdknryqdvkcqdkgrivvkfdgla..sdyihanylgiaikpkkficaqgplentqysfwamaiq

QDCCTIVMLSQEMESGKVKVHRYWPGKQPT-----------SIGNLVVEMLHdkqFDDYIMREFKVTNTKESASRVVRQYQFTAWPDIGSPDSGGGLIDL
..  ...|| . .| .|.|...||| ..             |. || .. |     |. ..   ..     . || ....|.. ||| | |.   . |.|
ekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakkla...pdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainl

IGQVQRWQQKcgvqlTAVHCSAGVGRTGVFCAVSILIERL-KAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYL
.  |.  .         |||||||||.|   |.|.. ... . .   |. . |..||.||.  .||. || . .. | ||.
leavrydtnp.....vvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 301-574 1.3e-77 255.6 In-house 14-289 (290) alignment 
Range on Protein: 301-574
Range on HMM: 14-289/290.0
STDTGQTEMDAEFQRLSRNKApPSKFQSANLPVNKHKNRYANVLPYDDTRVRLT-MQAVTE-GSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIW
 . .|.. . ..|..|   .  . . . .. . ||..||.||...||| |. |  ..   .   .|||| ||.||  ||..||||.|...|. |||..||
ghakgnegfrnqfkmldsges.ehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliw

EQDCCTIVMLSQEMESGKVKVHRYWPGKQPTSIGNLVVEMLHDKQFDDYIMREFKVTNTKE-SASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQ
..... |||| ...|.|||| . ||| .. ...|.  ...|.......|| |...|.|...  |.. | |||.|.|.. |.     . . .| .... | 
qekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqr

KCGVQLTAVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYLHSFDPY
| | .   ||||..|||..||||. . |.. | |  .|||| .|..| |.| .|||..||.. .| . .||.||. |
krgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 301-568 1.9e-36 120.3 In-house 18-289 (305) alignment 
Range on Protein: 301-568
Range on HMM: 18-289/305.0
STDTGQTEMDAEFQRLSRNKAPPS---KFQSAN-LPVNKHKNRYANVLPYDDTRVRLTMQAvteGSDYINANYIDGYM-SKKAFIATQAPIPDTIPDFWR
. | |   .  ||..|..   |      |.. .   ... ||||..|   | . |.|   .    |||| |||.   |  .| ||..| |. .|| .|| 
aldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefww

MIWEQDCCTIVMLSQEMESGKVKVHRYWP---GKQPTSIGNLVVEMLHDK-QFDDYimREFKVTNTKE----SASRVVRQYQFTAWPDIGSPDSGGGLID
|. ..    |||| . .| ||.|. .|||   |.. .  . .||| .     ..     | ..|  .     . .  ||. |.| ||| | |      ..
mviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerd..aeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltsle

LIGQVQRWQqkcgVQLtAVHCSAGVGRTGVFCAVSILIERLKAEA-MVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYL
|.  ..  .    | .  ||||||.||||   |.  ..|..  .     . . || ||.||   .|.  || | .. . .|.
llsairgsk....vpi.vvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Ptp69D_pd Subfamily Ptp69D 302-569 7.8e-87 286.3 In-house 20-287 (307) alignment 
Range on Protein: 302-569
Range on HMM: 20-287/307.0
TDTGQTEmdaEFQRLSRNkAPPSKFQSANLPVNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQD
|| | ..   |...| ..   . . . ..   |. |||| .. ..|.|||.|.    .| ||||||..| ||  || ||| |.|.  || ||||||.||.
tdfglak...eyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqe

CCTIVMLSQEMESGKVKVHRYWPGKQPTSIGNLVVEMLHDKQFDDYIMREFKVTNTKE-----SASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQ
  .|||||.. |  . |...|||  . .  |...|.. . .. .|||.||..|...||      .|| | ||..|.|.|   |..  ||..|| ||.  .
vtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrely

QKCgVQLTAVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYLH
..       |||||||||.|.| |...|...||||  ||.|.|||.||.||. .||  |||.|.|. | .| .
kln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 302-569 2.9e-83 274.2 In-house 10-277 (281) alignment 
Range on Protein: 302-569
Range on HMM: 10-277/281.0
TDTGQTEMDAEFQRLSR-NKAPPSkfQSANLPVNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQ
..  .. .  |.. |.  .   ..  .... . |..|||| |.  || |||..| .  .. .||||||...|| ..|..||||.|.|... .||.|.|||
sqndnaGfieeyeklaaigvdnta..taskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweq

DCCTIVMLSQEMESGKVKVHRYWPGKQ-PTSIGNLVVEMLHDKQFDDYIMREFKVtNTKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQKC
. ..|||. .|.|.||.| ||||| ..  ...|...|.... ..   || |.||. ..... .| |.| ..||||| | |..   |..   .|.. ..| 
kvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekk

GVQLTAVHCSAGVGRTGVFCAVSILIERLKAE-AMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYLH
  .   .||||||||||.. |.  |.....|| ...|| ..|..||..|  ||||  |||| |... ..|.
tkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_PTPN23_pd Subfamily PTPN23 302-567 1.8e-68 225.5 In-house 10-279 (288) alignment 
Range on Protein: 302-567
Range on HMM: 10-279/288.0
TDTGQTEMDAEFQRLSRNKAPPSKFQS-ANLPVNKHKNRYANVLPYDDTRVRLTmqavTEGSDYINANYIDGYMSK-KAFIATQAPIPDTIPDFWRMIWE
.  |.|..|..|. | ....  .. .| |   .. .|||. ..|||| .|| |      .  ||||| .. .  .    |||||||.. |. |||.|..|
mldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvye

QDCCTIVMLSQEMESGKVKVHRYWPGK--QPTSIGNLVVEMLHDKQFDDYIMREFKVTNTKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQR---
|   .|||| .. | || ||.|||| .  .... |.| | . . .. . .. |..|..  ...| . |.  |.|.||..| |.| . |......|.    
qkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesaye

-WQQKCGVQLtAVHCSAGVGRTGVFCAVSILIERLK-AEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEY
  |.|. . |  |||||||||||||. |   .. |.  . ..|. | |..|||||  |||.|||..|.|.   |.
avqrksktPl.vvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
0045450 (Phosphotyrosine protein) phosphatases II 303-568 5.4e-90 297.5 In-house 23-304 (307) alignment 
Range on Protein: 303-568
Range on HMM: 23-304/307.0
DTGQTEMDAEFQRLSRNKAP-PSKFQSANLPVNKHKNRYANVLPYDDTRVRLTMQAVT-EGSDYINANYI--------DGYMSKKAFIATQAPIPDTIPD
 .. | . .||..| . . . . .. .|.||.||.|||| ..||||.|||.|.    . |.||||||.|.        ||| .|..|||||.| |.|. |
ldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetved

FWRMIWEQDCCTIVMLSQEMESGKVKVHRYWPGK-QPTSIGNLVVEMLHDKQFDDYIMREFKVTNT-KESASRVVRQYQFTAWPDIGSPDSGGGLIDLIG
||||.|||.. .||||....| |..| ..||| . ..  .||..|..|  .. |.|..| ..||.. ... || |.....|.||| | |.|   |.|.| 
FwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfie

QVQRWQQKC-GVQLTAVHCSAGVGRTGVFCAVSILIERLKAEAM---VDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYL
.|....... .   ..|||||||||||.|.|  .....|..| .   ||....||.|||||| .||. |||.|.|. | |.|
evrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 304-575 4.4e-147 484.2 In-house 17-287 (318) alignment 
Range on Protein: 304-575
Range on HMM: 17-287/318.0
TGQTEMDAEFQRLSRNKAPPSKFQSaNLPVNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCC
.|......|..||||... .....| . ||||.||||||.|.||.|||.|.|....||||||||||||||..|||.||.|||.|.||.|||||.|||...
sGelllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsa

TIVMLSQEMESGKVKVHRYWPGKQPTSIGNLVVEMLHDKQFDDYIMREFKVTNTKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQKCGVQL
.||||.||.|.||.|||||||.|...|.|.||||. ......||..||||||.|.|..||.||||..|.||| |.|.||..|.||..||...|||.|...
vivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagp

TAVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYLHSFDPYN
..|||||||||||||.||.||.||.||||.||||||||||||||..||||..||||.|..| |.|.|.|.. 
ivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtev
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 304-572 2.6e-99 327.3 In-house 20-287 (319) alignment 
Range on Protein: 304-572
Range on HMM: 20-287/319.0
TGQTEMDAEFQRLSRNKAPpsKFQSANLPVNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCC
||.| .. ||. |.  ..   .|.||. . ||.|||| |.|.|| ||| |.    .||||||||..||||  ...|||||||. .|| |||||.||... 
tgetllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeess

TIVMLSQEMESGKVKVHRYWPGKQPTSIGNLVVEMLHDKQFDDYIMREFKVTNTKESA-SRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQKCGVQ
..|||..  | .|||...||| ..... |.|.|....... .|||.|..|. . ..   .| | ..|.|.||| . |... .|.||...... ..|   .
ivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsg

LTAVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYLHSFD
   ||||||||||| |..... .||.| |...|||.||..|| ||. |||..|||.|.|..| |.....|
PivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
0047943 (Phosphotyrosine protein) phosphatases II 304-568 3.7e-95 313.8 In-house 9-272 (273) alignment 
Range on Protein: 304-568
Range on HMM: 9-272/273.0
TGQTEMDAEFQRLsRNKAPPSKFQSANLPVNKHKNRYANVLPYDDTRVRLtmqaVTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCC
.| | . .||..| ..  |. ... |.|| ||.|||| ..||||..||.|      .|||||||.|.||| .|..|||||.| |.|. |||||.|||.. 
lgltllleefell.lslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvr

TIVMLSQEMESGKVKVHRYWPGKQ---PTSIGNLVVEMLHDKQFDDYIMREFKVTNTKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQKC-
.|||| ...| |..| ..||| ..   ..  |.. |..|  ...|||..|....||.. . ||.|.....| ||| | |.|   |...| .|....... 
viVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealp

-GvQLTAVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYL
 .   ..|||||||||||.|.|. .|...|..| .|||...||.||.||| |||| |||.|.|..| |||
sn.gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0043336 (Phosphotyrosine protein) phosphatases II 304-568 2.5e-92 304.6 In-house 17-277 (278) alignment 
Range on Protein: 304-568
Range on HMM: 17-277/278.0
TGQTEMDAEFQRLSRNKAppSKFQSANLPVNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCC
...| . .||..| ..|     .  |.|| ||.|||| ..|||| .||.|..    ..||||||.|.|||  ...|||||.| |.|. |||||.||... 
nlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvt

TIVMLSQEMESGKVKVHRYWPgKQPTSIGNLVVEMLHDKQFDDYIMREFKVTNTKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQkCGVQL
||||| ...| |.|| ..||| .... .|...|..|  ...|||..| ..|||.... || |..|....||| | |.|   |.|.. .|.....      
tivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngp

TAVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYL
..|||||||||||.|.|. .|.|.|. |  ||....||.|||||| .||| .||.|.|. | |||
vlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 304-564 1.7e-88 291.4 In-house 18-275 (288) alignment 
Range on Protein: 304-564
Range on HMM: 18-275/288.0
TGQTEMDAEFQRLSRNKAPpSKFQSANLPVNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCC
...|..  |.. |.  .   .. . ..|.||..|||| |.|||| .||.|.    ..|.|||||.||||. .||..||||.|..||. |||....|..  
rnrtgfseeynsLaalekt.ksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenkts

TIVMLSQEMESGKVKVHRYWPGKQ-PTSIGNLVVEMLHDKQFDDYIMREFKVTntKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQKCgVQ
|||||.. .| || | ..||| .. |.  |.. |.....|. .|...|.. .   |.   . . |||..|||| | |.|   |..|. ||.  .|.  ..
tivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.tg

LTAVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTL
   |||||||||||.| |.  ||.....| ..||. ||..||.||. .|||..||||.|..|
piivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevl
subfamily_PTPRG_pd Subfamily PTPRG 304-570 9.6e-79 260.1 In-house 16-289 (563) alignment 
Range on Protein: 304-570
Range on HMM: 16-289/563.0
TGQTEMDAEFQRLSRNKAPP-SKFQSANLPVNKHKNRYANVLPYDDTRVRLTMQAVTEGS-DYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQD
 |.. ...||. | .. ..   . .... | ||.|||| |...|| .||.|.  . .... |||||||||||  .||||||| |..||. ||||||||| 
dgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqn

CCTIVMLSQEMESGKVKVHRYWPGKQPTSIGNLVVEMLHDKQFDDYIMREFKVTN-----TKE-SASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRW
  .|||...  |.|. | ..|||  ..  .|.| | . . ...  | .|.... |     .|.    ..||||..| ||| |.|..    .  . . .. 
vaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaa

QQKcGVQLTAVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYLHS
...  .  . |||||||||||...... |......| .|.||...|..| ||. .|||.||| | ...| | . |
nka.eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
0036941 (Phosphotyrosine protein) phosphatases II 305-573 1.3e-93 308.8 In-house 11-282 (297) alignment 
Range on Protein: 305-573
Range on HMM: 11-282/297.0
GQTEMDAEFQRLSRNKApPSKFQSANLPVNKHKNRYANVLPYDDTRVRLtmqaVTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCCT
. . .  ||..| .... . ..  |.|| |..|||| ..||||.|||.|      ||||||||.|.|||  |..|||||.| |.|. |||||.|||.. .
flalllkefeellplll.lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtv

IVMLSQEMESGKVKVHRYWPGK--QPTSIGNLVVEMLHDKQ--FDDYIMREFKVTNTKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQKC-
||||....| |..| ..||| .  ..   |...|..|. ..  .|||..|...||.|... ||.|.....| ||| | |.|   |.|.| .|......  
Ivmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllp

GVQLTAVHCSAGVGRTGVFCAVSILIERLK---AEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYLHSFDP
.   . |||||||||.|.|.|. .....|.    |  ||....||.|||||| .||| |||.|.|..| |.| ....
sggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
0039614 (Phosphotyrosine protein) phosphatases II 305-571 1.8e-90 298.7 In-house 30-292 (297) alignment 
Range on Protein: 305-571
Range on HMM: 30-292/297.0
GQTEMDAEFQRLSRNKAPpskFQSANLPVNKHKNRYANVLPYDDTRVRLTMQAVT-EGSDYINANYIDGYMS-KKAFIATQAPIPDTIPDFWRMIWEQDC
. | ...||..| ..| .   .  |.||.||.|||| ..||||..||.|..   . ..||||||.|.|||   ...|||||.| |.|. |||||.|||..
sktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgv

CTIVMLSQEMESGKvKVHRYWPGKQPtSIGNLVVEMLHDKQFDDYIMREFKVTNTKESasRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQKC-GV
 .|||| ...| |. | ..||| ..    |...|..|  .. |.|..|...|||..||  | |...|.| ||| | |.|   |.... .|....... . 
tvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtnnges..rtvthfqytgwpdhgvppslellleflelvrealaelpkg

QLTAVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYLHSF
  ..|||||||||||.|.|  ...|.|. |  |||...||.|||||| .||| .||.|.|. | |.|  .
gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 305-574 2.9e-61 201.8 In-house 13-299 (301) alignment 
Range on Protein: 305-574
Range on HMM: 13-299/301.0
GQTEMDAEFQRLSRNKAPPSKFQSANlpVNKHKNRYANVLPYDDTRVRLTMQAV--TEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDC
 ..........|....  ... .  .   ||. ||. |. .||| |. |. .    .   .||||.||||| .||.|||.|.|.  |. ||||.||..  
hsnkfeeqykelkegedksctvglse..enkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekp

CTIVMLSQEMESGKVKVHRYWPG--KQPTSIGNLVVEMLHDKQFDDYIMREFKVTNTK---------------ESASRVVRQYQFTAWPDIGSPDSGGGL
 .|||. .. |. | | ..|||   .. .. |.. |.. ... . |...|...|. ..               . .|. | |.| | ||. |        
vsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtv

IDLIGQVQRWQQKCGVQLTAVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYLHSFDPY
.  | .|   ||| |     ||||..|.|.||.|.||| .|  |||  ||||| .| .| ..| .|.| ||| . |. . .||.  . |
LqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnsty
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 305-567 2.4e-24 80.3 In-house 24-284 (302) alignment 
Range on Protein: 305-567
Range on HMM: 24-284/302.0
GQTEMDAEFQRLSRNKAPPSKfqSANLPVNKHKNRYANVLPYDDTRVRLTMQAvtegSDYINANYIDGYMSKKAFIATQAPIPDTI---PDFWRMIWEQD
 ..|. .||....  |..  |        | .||.  .|  .|...|.|....     .|.||  ..    ..  | .| |. |.     .||||.... 
dtaevkkefkkidtmkvdlek..Ckafkknlkknqsedvpildsnlvkleaep....dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqek

CCTIVMLSQEMESGKvKVHRYWP--GKQPTSIGNLVVEMLHDKQFDDYI-MREFKVTNTKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQK
. ..|.| .| |  |  .. ..|    . .  |.. |     .. ..   .    |     | | ..  | .| |..   |.. . ||  . .|   ..|
ivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkik

CgVQLTAVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEY
.  . |..    |.|| |.| .. . .|.|.... . . ..||..|.|||..|.. .|| . | .|  |
a.dentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiallly
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 306-572 1.6e-88 291.8 In-house 21-287 (305) alignment 
Range on Protein: 306-572
Range on HMM: 21-287/305.0
QTEMDAEFQRLSRNkapPSKFQSANLPVNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCCTI
.....|... | ..   .....  .  .||.|||.... ..|| |..|| .  .. ||||||.|.||| .||..|..|.|...|. ||||.|.|    ||
dkgleaqykslyee...eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvsti

VMLSQEMESGKVKVHRYWPGKQPT--SIGNLVVEMLHDKQFDDYIMREFKVTN-TKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQKCGVQ
|||.. .| || | ..|||...     .|...||.   |.. |||.|..|...  ... ||.| |||.| ||| | |.. . |..|| .||. |.|   .
vmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgv

LTAVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYLHSFD
   |||||||||||||.||.| .||||.| .||||. .||||..|. ||||..|| |... | |.....|
pllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 306-572 1.5e-73 242.5 In-house 20-288 (297) alignment 
Range on Protein: 306-572
Range on HMM: 20-288/297.0
QTEMDAEFQRLSRNKAPPSKFQSANLPVNK---HKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYIDGYMSkkAFIATQAPIPDTIPDFWRMIWEQDC
|....... .  ..  | .. |..    .|   .|.||.|.||||  ||.| .      |||.|| .. |.     .|.|| | ..|. |||.|..... 
qknrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqv

CTIVMLSQEMESGKvKVHRYWPGKQPTSIGNLVVEMLHDKQFDDYIMREFKVTNTKESASRVVRQYQFTAWPDIGSPD--SGGGLIDLIGQVQRWQQKCG
 |||||... |. | |  |||. |  |. |...|..|  ..   .| ||..||. |  | |||.||||. |||   .   |   |..|| .|.   ..  
stivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqna

VQLTAVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYLHSFD
     |||.||||||||....   . . | |  ||.|..||.||..|| .|||||||.| |... |.| | |
egPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsed
subfamily_PTPRN_pd Subfamily PTPRN 306-567 1.1e-61 203.2 In-house 28-291 (297) alignment 
Range on Protein: 306-567
Range on HMM: 28-291/297.0
QTEMDAEFQRLSRNKAPPSKFQSANLPVNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYI-DGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCCT
.. ...|.. | . .| ||  . |. . | .|||...|||||..||.|. .| .| ||||||  | |    . |.||||.|...|. |||.|.||| .. 
kdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvv

IVMLSQEMESGKVKVHRYWPGKQPTSIGNLVVEMLHDKQ-FDDYIMREFKVTNTKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQKCGVQl
||.|..  |.|  ...|||| .     .   |... ..   |||..| | . | . | .| | |. | .||. | | |   |...  .|..  .      
ivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscp.

TAVHCSAGVGRTGVFCAVSILIERLKA-EAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEY
  ||||.|.|||||.... ....||.     .|.  |.. ||.||| .|.||.|.||..... | 
ivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 306-567 2.3e-51 169.4 In-house 5-258 (267) alignment 
Range on Protein: 306-567
Range on HMM: 5-258/267.0
QTEMDAEFQRLSRNKAPPSKFQSANLPVNKHKNRYANVLPYDDTRVRLTmqavTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCCTI
..|.. ||. . .     |.        |. .||. ..|||||||| |     |.  .|||| |..||  |.|||.|| |.  || ||. .| .|.. .|
eceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilr....tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvi

VMLsqeMESGKVKVHRYWPGK--QPTSIGNLVVEMLHDKQFDDYIMREFKVTNTKESASRVVrQYQFTAWpDIGSpDSGGGLIDLIGQVQRWQQKCGVQL
|.|   . ... .....|| |  |     .|.||   .|. .|| .  ...   .|||  |.  | .  | .| . .    |  |.| . . | . | . 
vll...tkvftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvt.lyyykkw.nint.nnkpylkplfgilaknqlengnrP

TAVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEY
  |.||.||||.| |  .   .||.| | ..|.|. ....|.||...|.|||.| .....| ||
lvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 306-383 1.7e-14 47.8 In-house 22-94 (95) alignment 
Range on Protein: 306-383
Range on HMM: 22-94/95.0
QTEMDAEFQRLSRNKAPPSKFQSANlpVNKHKNRYANVLPYDDTRVRLTMQavtEGSDYINANYIDGYMSKKAFIATQ
. |.| ||. .|     |    |..   |  |||. |..||| ||| || .     |||||| ..|||  |...||.|
dqefdnefksismtsgapytvgsse..anipknrflnifpydatrvvlttk...rdsdyinacfvdgyarkncyiaaq
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 307-569 2.6e-67 221.6 In-house 10-278 (287) alignment 
Range on Protein: 307-569
Range on HMM: 10-278/287.0
TEMDAEFQRLSRN-KAPPSKFQSANLPVNKHKNRYANVLPYDDTRVRLTMqAVTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCCTI
 ..|.|...| .. .. .  |..|.   . .|||||.|||.||||| |.      |||||||||. .|  ..||||.|.||. |. ||||...|.  ...
ddvdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsa.egelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasv

VMLSQEMESGKVKVHRYWPGK-QPTSIGNLVVEMLH-DKQFDDYIMREFKVTNTKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQV----QRWQQKC
.....|.| .. |...||| . .|  .|   | .|  |..  .| .| ... . .   .|||.|... .||| . . .  ||| .. .|    .  ..  
itmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardas

GVQLTAVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYLH
.|    ||...|.||.|.. |. .|..||.    ||| ..| .|||.| |.||.  |. . |..|  | .
evGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
subfamily_PTPN14_pd Subfamily PTPN14 307-569 1.3e-60 199.9 In-house 23-297 (300) alignment 
Range on Protein: 307-569
Range on HMM: 23-297/300.0
TEMDAEFQRLSRNKApPSKFQSANLPVNKHKNRYANVLPYDDTRVRLTMQAVTeGSDYINANYIDGYMS--KKAFIATQAPIPDTIPDFWRMIWEQDCCT
... .|..|......  .....|.||.|..|||. .||||.|.||.|. .  .  ..||||  |   ..  .. .|..|.|.. |. |||.|.|||.   
gkvfteyeripkkre.dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvql

IVMLSQEMESGKVKVHRYWPGK----QPTSIGNLVVEMLHDKQFDDYIMREFKVTNTKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQKCG
|||| .| |.|| | ..|.| .    .    |.  |     .. | .| . .|.     .  | |   |.| ||| | |.   | .. . .||  ..|  
ivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktn

VQL--------TAVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYLH
 .           ||||||||||||   . .||. |. .  .|. .....|||||  .|||  ||.| |..| .||.
seveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 307-562 2.7e-57 188.8 In-house 6-260 (283) alignment 
Range on Protein: 307-562
Range on HMM: 6-260/283.0
TEMDAEFQRLSRNKAPPSKFQSANLPVNKHKNRYANVLPYDDTRVRLTMQAVtegsDYINANYID---GYMSKKAFIATQAPIPDTIPDFWRMIWEQDCC
..... ...| |   |. . . |    ||.|||. ...|.|  ||.|  ..     ||||| .|     |  .| .|..|.|. .|. |||.|..... .
nnnklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekit

TIVMLSQEMESGKVKVHRYWPGKQPTSIGNLVVEMLHDKQFDDYIMREFKVTNTKE-SASRVVRQYQFTAWPDIGSPDSGGGL--IDLIGQVQRWQQKCG
.||||.. .|  ..|  .||| .     |.. | . ..   . .|..|. . .     .. ..  ||.  | ..|       |  ....   |. ..|  
aivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgP

VqltAVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQ
.    ||||.|.|||.||.|.|  .. ...|..||||..|| .||||. .|||..|| . ..
i...vvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhe
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 307-568 3.9e-32 106.4 In-house 19-271 (288) alignment 
Range on Protein: 307-568
Range on HMM: 19-271/288.0
TEMDAEFQRlSRNKAPPSKFQsaNLPVNKHKNRYANVLPYDDTRVRLTmqavTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCCTIV
  .. |..  | |.|.    .  .   |  ..|| |.   | |||.|.     .   ||.|| .     |. .| .|||.  ||  .|.|. |.|   ||
eglkkeyrd.spneasidiid..sfianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyiv

MLSQEMESGKVKVHRYWPGK--QPTSIGNLVVEMLHDKQFDDYIMREFKVTNTKESASRV-VRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQkCgvql
||.. .| || |   |.| |  . . || |   . ....  | ...   . ..||   .| |..  .  |.| | |..    . |.  ..  |.      
mlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqk.P....

TAVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYL
  ||.|||||||| .  . | .| |. .  . . . ...|||.|   .||. || . .. . |.|
ivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel
0040438 (Phosphotyrosine protein) phosphatases II 308-571 3e-94 311.1 In-house 19-279 (317) alignment 
Range on Protein: 308-571
Range on HMM: 19-279/317.0
EMDAEFQRLSRNKAPpsKFQSANLPVNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCCTIVM
 .  ||..| ..| .   .. |.||.||.|||| ..||||..||.|.     ..||||||.|.||.  |..|||||.| |.|. |||||.|||....|||
alleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivm

LSQEMESGKVKVHRYWPGKQPTSIGNLVVEMLHDKQFDDYIMREFKVTNTKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQkCGVQLTAVH
| ...| |..| ..||| .... .|...|..|  .. .....|...|.....| || |.....|.||| | |.|   |.|.. .|.....  .   ..||
LteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVH

CSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYLHSF
|||||||||.|.|. ...|.|. |  |||...||.|||||| .||| |||.|.|. | |||  .
CsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk
subfamily_PTPN12_pd Subfamily PTPN12 308-568 2.5e-82 271.0 In-house 9-277 (290) alignment 
Range on Protein: 308-568
Range on HMM: 9-277/290.0
EMDAEFQRLSRNKAP--P---SKFQSANLPVNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDC
|. .|||.| . ..        . .... ..|..|||| ..|||| .|| |. .  .|||||||||.| |  .|...||.|.|.|.|. ||||||||.. 
efakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknv

CTIVMLSQEMESGKVKVHRYWPGKQPTSI--GNLVVEMLHDKQFD-DYIMREFKVTNTKEsaSRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQKC
  .||. .|.| || | .|||| .. ...  |.. |.. ..|..| |...| .||.. ||  ||.|.|...||||| | | |   |..|| .|.. |.. 
eivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqke..srkvyqfhYtaWPDhgvPssaksllelielvrelqese

GVQLtAVHCSAGVGRTGVFCAVSILIERLKAEAM---VDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYL
 . | .|||||||||||. .|. .  | |||| .   .|||. | .||.||.|.||||||||. |... |..
daPl.vvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_PTPN13_pd Subfamily PTPN13 308-569 1e-71 236.4 In-house 12-270 (273) alignment 
Range on Protein: 308-569
Range on HMM: 12-270/273.0
EMDAEFQRLSRNKaPPSKFQSANLPVNKHKNRYANVLPYDDTRVRLTMQAVtegsdYINANYIDGYMSKKAF--IATQAPIPDTIPDFWRMIWEQDCCTI
. . ||. |   | |  . ....   ||.|||| ||||||.|||.|  ..      ||||..|   . |. .  ||.| |.|.|. |||.|.|||..  |
qPaeefkelrelk.pldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaevi

VMLSQEMESGKVKVHRYWPGK--QPTSIGN-LVVEMLHDKQFDDYIMREFKVTNTKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQKCGvq
.|...| |.|||| ||||| .  ... . | | ||.|. .. |.. .|...|.... ..|| | . .|..||| | | |   |. .. .|.| |.. |  
amvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdag..

LTAVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYLH
  .||||||.||.|.. .. .... .. .  .|| ..|..||||| ..||||.|| |.|... | |.
PivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 308-567 9e-40 131.1 In-house 28-282 (290) alignment 
Range on Protein: 308-567
Range on HMM: 28-282/290.0
EMDAEFQRLSRNKAPPSKFQSANLPVNK--HKNRYANVLPYDDTRVRLTMqaVTEGsDYINANYIDGYmsKKAFIATQAPIPDTIPDFWRMIWEQDCCTI
|.  |.    .   |   ..   .  |   .|||| .|   | ||| |      .| ||. |||..|   |  || || .. ||. |.|||. ...  .|
elakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkd..GydG.dyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaai

VMLSQEMESGKVKVHRYWPGKQPT--SIGNLVVEMLHDKQFDDY-IMREFKVTNTKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRwqqKCGVq
||| . .| || | ..|.| |.    ..|.. |    ... |.  |.. . | . ..  . ... ..  .|||   . |   |. ..  ...     |  
vmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk...asGp.

lTAVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEY
  .||||||.|||| | |. . .. |     .|. ..|. ||. | . ||   ||    . | ..
.vvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 308-481 1e-35 118.0 In-house 8-182 (297) alignment 
Range on Protein: 308-481
Range on HMM: 8-182/297.0
EMDAEFQRLSRNKaPPSKFQSANLPVNKHKNRYANVLPYDDTRVRLTmqAVTEGSDYINANYIDGY--MSKKAFIATQAPIPDTIPDFWRMIWEQDCCTI
|..|| . | ...  . .| ||. .   .|||| ..| .|||||.|    |  ..|||||.|.      ..  .| .| |. .|. |||....|||  .|
eleaekdllldea.rgesfssakrnsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvi

VMLSQEMESGKVKVHRYWPGKQ--PTSIGNLVVEMLHD--KQFDDYIMREFKVTNTkeSASRVVRQYQFTAWPDIGSPDS
||...  | |. |   |||  .      |..||| | .   .||  |. |...     | |||||  || .||| | |  
vmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsd
0046845 (Phosphotyrosine protein) phosphatases II 309-573 1.7e-97 321.5 In-house 2-279 (284) alignment 
Range on Protein: 309-573
Range on HMM: 2-279/284.0
MDAEFQRLSRNKAPPS-KFQSANLPVNKHKNRYANVLPYDDTRVRLTMQAVT-EGSDYINANYIDGY-----MSKKAFIATQAPIPDTIPDFWRMIWEQD
...||..| ... ... ..  |.|| |..|||| ..||||..||.|..   . |.||||||.|.|||     ..||.|||||.| |.|. |||||.|||.
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

CCTIVMLSQEMESGKVKVHRYWPGKQ-PTSIGNLVVEMLHDKQFDDYIMREFKVTNTK-ESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQK-
. .|||| ...| |..| ..||| .. .  .|.. |..|. ...|||..|....||.. .. || |.....|.||| | |.|   |.... .|...... 
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

CGVQLTAVHCSAGVGRTGVFCAVSILIERLKAEA---MVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYLHSFDP
 |   ..|||||||||||.|.|. .|.|.|..|    .|||...||.|||||| |||| |||.|.|..| ||| ..  
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt
DSPc_SM00195 309-568 2.1e-92 304.6 In-house 2-262 (263) alignment 
Range on Protein: 309-568
Range on HMM: 2-262/263.0
MDAEFQRLSRNKAPPsKFQSANLPVNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCCTIVML
...||..| ... |  ....|. . ||.|||| |.||||.|||.|. .  .|||||||||||.|. .||..||||.| |.|. |||||.||... .||||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

SQEMESGKVKVHRYWPGK--QPTSIGNLVVEMLHDKQFD-DYIMREFKVTNTKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQKCgVQLTA
..|.|.|| |..|||| .  ... .|.. |.. . .. . ..|.|....|..... .| |.|||...||| | |||   ...|. .|. ....   . . 
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYL
|||||||||||.|....|....|..| .||.|..||.||.||| ||||.||| |.|... ||.
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 309-568 2.1e-92 304.6 In-house 2-262 (263) alignment 
Range on Protein: 309-568
Range on HMM: 2-262/263.0
MDAEFQRLSRNKAPPsKFQSANLPVNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCCTIVML
...||..| ... |  ....|. . ||.|||| |.||||.|||.|. .  .|||||||||||.|. .||..||||.| |.|. |||||.||... .||||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

SQEMESGKVKVHRYWPGK--QPTSIGNLVVEMLHDKQFD-DYIMREFKVTNTKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQKCgVQLTA
..|.|.|| |..|||| .  ... .|.. |.. . .. . ..|.|....|..... .| |.|||...||| | |||   ...|. .|. ....   . . 
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYL
|||||||||||.|....|....|..| .||.|..||.||.||| ||||.||| |.|... ||.
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 309-569 5.6e-73 240.4 In-house 7-269 (274) alignment 
Range on Protein: 309-569
Range on HMM: 7-269/274.0
MDAEFQRLSRNKaPPskfQSANLPVNKHKNRYANVLPYDDTRVRLTMQAVTEG-SDYINANYIDGYMS-KKAFIATQAPIPDTIPDFWRMIWEQDCCTIV
...||  |  |  ..   .  ... ...|||| ..|| . .|| |. . ...  |.||||||| ||   .||..||| |.| |. ||||||.....  ||
lekeflelPlnf.dq...eeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqviv

MLSQEMESGKVKVHRYWPGKQPT----SIGNLVVEMLHDKQFDDYIMREFKVTNTKEsaSRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQKCGVQ
|| .  |. . | ..|.| .. .      |.. ... . .. .|| .|.. . ....  .| |  | .|.|||  |||.   |.||. .|.. ...   .
mltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenak

LT--AVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYLH
|.   ||||||.||||.| |.|| . .|..| .|||...| .|| .|  ||||.||||. ...| .||.
lapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_PTPN3_pd Subfamily PTPN3 309-563 2.1e-70 231.9 In-house 17-270 (280) alignment 
Range on Protein: 309-563
Range on HMM: 17-270/280.0
MDAEFQRLSRnKAPPSKFQSANLPVNKHKNRYANVLPYDDTRVRLTMQAVtegsDYINANYIDGYM----SKKAFIATQAPIPDTIPDFWRMIWEQDCCT
. |.|..| | | |  . . |..| | .|||| ..||||.|||.|. . .    |||||||..  .      . .|||| |...|  |||.|.|||.. .
vlaqfeqlyr.kkpglaisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssl

IVMLSQEMESGKVKVHRYWPGKQ-PTSIGNLVVEMLHDKQFDDYIMREFKVTNTKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQkCGVQL
|||| . .|.|.|| |.||| ..  .. |.. |.. ....   |..||. ....... .| . | |..|||| | ||.   ..... .|.. ..    . 
ivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrs.gkeeP

TAVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQT
. ||||||.|||||. .. . .  . |.  | . . |...|.|| ..|||..||.|  ..
vvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCea
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 310-570 2.1e-69 229.2 In-house 26-290 (325) alignment 
Range on Protein: 310-570
Range on HMM: 26-290/325.0
DAEFQRLSRNKapPSKFQSANLPVNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMI--WEqdcCTIVM
  ||. |  .   .  .. | .| || |||. ||...| .|| |  .     ||||||.|.  .. |. |.|.||| ..|| |.||..  |.   |..|.
ahefgllpsdd..giakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr...csvvv

LSQEMESGKVKVHRYWPGK--QPTSIGNLVVEMLHDKQFDDYIMREFKVTNTKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQKCGV----
.  |.. || .   ||| .  .    | | |..   ... ||..| ..| ..|.  .| |.|.|. .|.|.| .     || ..  |.  ...       
vlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantka

-QLTAVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYLHS
     ||||||||||||| ..  .....  |. ||.|. ||.||..||.||.| .|| ..|..| |.. |
stpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveayms
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 311-567 5.4e-82 270.5 In-house 2-255 (284) alignment 
Range on Protein: 311-567
Range on HMM: 2-255/284.0
AEFQRLSRNKAPPSKFQSANLPVNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSq
.||.|...  .. .. . |||. || |||. ..|..| ..|.|      |.|||||| .| || .|. .|||| | ..|. ||||||||..|.|||.|. 
vefrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.

emesgKVKVHRYWPGKQPTSIGNLVVEMLHDKQFDDYIMREFKVTN-TKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQKCG-VQLTAVHC
     | |  .||| |     ..  |..   .. ..|..|...... .||   | .||. |  ||| | ||..  |. |. .|.  ..|    .   |||
.....kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhc

SAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGE-Y
|||||||||. .. .|..|.| | .|||...|..||.||. .||   || |.| .| | .
sagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh
0049772 (Phosphotyrosine protein) phosphatases II 311-571 5.6e-51 169.5 In-house 23-283 (314) alignment 
Range on Protein: 311-571
Range on HMM: 23-283/314.0
AEFQRLSRNKAPPSKFQSANLPVNKHKNRYANVLPYDdTRVRLTMQAVTeGSDYINANYIDGYmskKAFIATQAPIPDTIPDF----------WRMI--W
... |.| .  |.  .  |.|..|..|||| ..||.| .||.|  . |  |||||||.|.||.   ..|||||.| . |. ||          |||.  .
lvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvilpglpvs.gsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrg

EQDCCTIVM---------------------LSQEMESGkvkvhrywPGKQPTSIGNLVvemlhdkqfddyimrefKVTNTKESASRVVRQYQFTAWPDiG
.... .|||                     | . .. |        .   .  . .|                  .... .|  .| . .|  . .|| |
dlnvrdivmsrdevladelsrLdaAlgKtpllildgng........neptaadlellk.................eelydpelferlgikylripvpD.g

SPDSGGGLIDLIGQVQRWqqkCGVQLTAVHCSAGVGRTGVFCAVSILIERLKaeamVDVFQTVKQLREQRP-----AMVQTKEQYEFCYQTLGEYLHSF
|...   . ...  ....        ..|||.||.||||.|... .|. .|.    |.. ......|..||      .... |||||... | |||  .
saplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealleylkfl
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 311-566 5.2e-38 125.3 In-house 15-267 (281) alignment 
Range on Protein: 311-566
Range on HMM: 15-267/281.0
AEFQRLSrnKAPPSKFQ-SANLPVNKHKNRYANVLPYDDTRVRLTM-QAVTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCCTIVML
 ||  |     ||| .    | |||..||||.|.   | .||.| .     . .||| ||||   . |. .| || |  .|  |||||||...  .||||
qefsnlp..gdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivml

SQEMESGKVKVHRYWPGKQPTSIGNLVVEMLHDKQFDDYIMREFKVTNTKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQqkcgvQLTAVHC
 | .|. . |.  |.| .    .    . . ..    .  .   ..  . |  .|.. .. .  |||   |.|   .. .. ...            .||
cqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirars.....tppvihc

SAGVGRTGVFCAVSILIERLKAE-AMVDVFQTVKQLRE-QRPAMVQTKEQYEFCYQTLGE
||||||.| . || | .. ...  .. |. | | .||   | | ||| .|| . .. | .
sagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_ptpA1_pd Subfamily ptpA1 312-529 6.3e-47 155.2 In-house 26-257 (418) alignment 
Range on Protein: 312-529
Range on HMM: 26-257/418.0
EFqRLSRNKAPPSKFQSANLPVNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYIDGYMSkKAFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQE
|| ||  .   ||.    .   |  ||||.|.|| . |||.|      |||||||||||||    | ||.|| |.|.|| |||||.||. |  |||||.|
ef.rlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsre

MESGKVKVHRYWP----GKQPTSIG-------NLVVEMLHDKQF--DDYIMREFKVtnTKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQK
 |  ..|. ||||    |.| .  |          ||..   |    . | |. ..  | |  .| . |||.  |||   ||    . .|.  .   |..
sencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirl..tfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnq

CGV-----QLTAVHCSAGVGRTGVFCAVSILIERLK
            ||||||||||| ||.  |....| 
iipssdrnvpiivhcsagvgrtgtfctavimmkkld
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 312-568 1.2e-21 71.6 In-house 27-279 (303) alignment 
Range on Protein: 312-568
Range on HMM: 27-279/303.0
EFQRLSRnKAPPSkFQSANLPVNKHKNRYANVLPYDDTRVRLTmqavteGSDYINANYIDGYMSKKAfIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQE
||....    |||     ..  | .|||...|.  | ..|.|.       | || |.|..   |||| | || |.. |  |||.|| ||    ...|  .
efekvvs.ylpps.vsknqfvknmdknrfvdvicldhskvkls......dssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltd

MESGKVKVHRYWPGKQPT-SIGNLVVEMLHDK---QFDDYIMREFKVTNTKESAsrVVRQYQFTAWPDIGSPDSG-GGLIDLIGQVQRWQQKCGVQLTAV
 |  |.  .  .| .|    . . .. .   |     | . ..   |.| .  .   .  ... |||    |  |   ..  | |.|   .|      .|
seydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyks..flhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptv

HCS-AGVGRTGVFCAVSILIERLKAE-AMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYL
. | .|.||.| |.        |..| | .|. . ....|. |   ||   |. . |  | |..
ymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 313-569 3.7e-65 214.6 In-house 1-265 (270) alignment 
Range on Protein: 313-569
Range on HMM: 1-265/270.0
FQRLSRNKAPPSKFQsaNLPVNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYIDGYMS-KKAFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQE
|..|..... .|..   .   .|. ||||..||   |||||     .. . ||||||. |. . ||..||...| | |. .|||||||.   .|||... 
fkeldkeetsesdlp..eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgl

MESGKVKVHRYWPGKQPT----SIGNLVVEMLHDKQFDDYIMREFKVTnTKESASRVVrQYQFTAWPDIGSPDSGG------GLIDLIGQVQRWQQKCGV
.| |. |  |||| .. .    . |.. |  |.... . ||... ... .| .  |.|  .....||| | | . .       |. .. .|.|....   
eEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle.ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldk

Q-LTAVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYLH
.  . |||||||||||.. |. | .. |. .  ||| . ...||..|.|.||. ||||| |... || .
aePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_egg_pd Subfamily egg 317-564 6.1e-25 82.5 In-house 23-266 (307) alignment 
Range on Protein: 317-564
Range on HMM: 23-266/307.0
SRNKAPPSKFQSANLPVNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESgk
. . .    .. |    |..| |   |   | .||.| ..      |.| ||...|      || .|||. .|  |||||......  ||||.   ||  
leesvdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..

VKVHRYWPGKQ--PTSI--GNLVVEMLHDKQFDDYIMR--EFKVTNTkESASRVVRQYQFtAWPDIGSPDSGgglIdligQVQRWQQKCgVQLTAVHCSA
 . . |||  .  .  .  |.| .| |. ..  | ..|  ..|.  . .   | .  .|   .   .   |    .    .| |  ..   . . |..  
erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGg.ddeerflehwqg.dvnnssdvysp...l....rvlrklrnl.skpvvvqdil

GVGRTGVFCAVSILIERLKAEA--MVDVFQTVKQLREQRPAMVQTKEQYEFCYQTL
|| ..... |. | .  |         | ..|. || .|.  |..  .| | |. .
GvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlv
subfamily_PTPN1_pd Subfamily PTPN1 319-564 7.6e-58 190.5 In-house 17-267 (290) alignment 
Range on Protein: 319-564
Range on HMM: 17-267/290.0
NKAPPSKFQSANLPVNKHKNRYANVLPYDDTRVRLTMQAVtegsDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESGKVK
..|   . ..|.|| |. .||| .| ||| .|..|  . .    |||||. ..    |. .| || |.|.|.  ||.|.|||.. ..||| . .| ...|
keasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqik

VHRYWPGKQP---TSIG--NLVVEMLHDKQFDDYIMREFKVTNTKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQ-KCGVQLTAVHCSAGV
 ..||| ..      .   .| |.... .. . |..| ....| |   .|.. .. .|.||| | |.| . ..... .|..    .  |  . .|||||.
caqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGi

GRTGVFCAVS---ILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTL
||.| || |    .|||. .  . ||. ... .||..|  ..||..| .| |...
GrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylai
0045098 (Phosphotyrosine protein) phosphatases II 320-570 7.7e-85 279.9 In-house 19-274 (278) alignment 
Range on Protein: 320-570
Range on HMM: 19-274/278.0
KAPPSKFQSANLPVNKHKNRYANVLPYDDTRVRltmqavtegsDYINANYIDGYmsKKAFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESGKVKV
  .||..  |... |..|||| ..|||| .||.          |||||.|||||  .|.|||||.| |.|. |||||.||... .|||| ...| |..| 
lgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekc

HRYWPGKQPTSIGNLVVEMLHDKQFDDYIMREFKVTNT----KESASRVVRQYQFTAWPDIGSPDSG--GGLIDLIGQVQRWQQ--------------KC
..||| ...  .|...|..|  ...|||..| ..|||.    ..  || |...... ||| |.|..     ...|. .......              . 
aqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsg

gvQLTAVHCSAGVGRTGVFCAVSILIERLkaEAMVDVFQTVKQLREQRPA-MVQTKEQYEFCYQTLGEYLHS
    ..|||||||||||...|. ...|.|  |  ||....||.||.|||  .||..|||.|.|. | |.|. 
..gpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_PTPRD_pd Subfamily PTPRD 322-572 2.2e-122 404.6 In-house 36-285 (564) alignment 
Range on Protein: 322-572
Range on HMM: 36-285/564.0
PPSKFQSANLPVNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESGKVKVHR
. .....|| |.||.||||||...|| .||.|..   .||||||||..||||...||.||||.|...|| |||||.|||...|||||..  |.||||.|.
qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchk

YWPGKQPTSIGNLVVEMLHDKQFDDYIMREFKVTNTKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQqKCGVQLTAVHCSAGVGRTGVFCAV
||| |.....|.|.|.. . ... ||..|.||....|.| || |||..||.||| | |.|. .|.||| .|.... ... . . |||||||||||.|...
YWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfivi

SILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYLHSFD
....||.|.|..||..|.||.||.||.|||||.||| |..... |.|....
damlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgn
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 322-569 1e-74 246.3 In-house 32-278 (315) alignment 
Range on Protein: 322-569
Range on HMM: 32-278/315.0
PPSKFQSANLPVNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESGKVKVHR
.... ..|  ..| .|||| |.||.| .||.| .   .  |||||| || .. . ||.||.|.| . .. |||||.....  ||||...  |. |.|  .
diyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrq

YWPG--KQPTSIGNLVVEMLHDKQFDDYIMREFkVTnTKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQKCGVQLtAVHCSAGVGRTGVFC
|||    . .  |.. ||.|  ..  | ..|.. ||  |  .|| | |.||| ||| |..   . |. || .|.  ..|    |  ||||||||||||..
ywPdrkadsvefGsikvellsleadtdgvarkl.vt.rkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsl.lvhcsaGvGrtGvvi

AVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYLH
..   ....| . .||||..||.||..|| .|||.|.| | |... |.|.
sidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 322-408 1.1e-12 42.2 In-house 25-116 (347) alignment 
Range on Protein: 322-408
Range on HMM: 25-116/347.0
PPSKFQSANLPVNKHKNRYANVLPYDDTRVRLTMQA-----VTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCCTIVML
 |||| |..   .  |||  .|   |.||| |. .        .   |||| .|    ..| .| || |.|||. |||.|.       .| .
spskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_PTPRA_pd Subfamily PTPRA 325-568 7.1e-92 302.8 In-house 49-295 (330) alignment 
Range on Protein: 325-568
Range on HMM: 49-295/330.0
KFQSANLPVNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESGKVKVHRYWP
 .. |.   ||.|||. |.|||| .|| |...  .| |||||| .||||  |. |||.| |  .|. |||||||||. .|||||..  |  . | ..|||
tlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywP

GKQPTSIGNLVVEMLHDKQFDDYIMREFKVT----NTKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQKCGVqLTAVHCSAGVGRTGVFCA
 .   . ||. ||. ...   || .|.| |.    .|.| .||.|||. ||.|||.| |  . |...|. .|.. .|. .     ||||||||||| |..
deGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfiv

VSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYL
.. ..||.||| .||||..||.|| ||| ||||.|||||.|..| || 
ldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
0040439 (Phosphotyrosine protein) phosphatases II 326-568 2.4e-84 278.1 In-house 3-246 (249) alignment 
Range on Protein: 326-568
Range on HMM: 3-246/249.0
FQSANLPVNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESGKVKVHRYWPG
.  |.||.||.|||| ..|||| .||.|.     ..||||||.||||| .|..|||||.| |.|..|||||.||... .||||....| |..| ..||| 
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

KQPTSIGNLVVEMLHDKQFDDYIMREFKVTNTKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQKC-GVQLTAVHCSAGVGRTGVFCAVSIL
.... .|...|..|. ...|||..|....||.... || |...|.| ||| | |.|   |.|.| .|. .....     ..|||||||||||.|.|  ..
ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm

IERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYL
.|.|. |  ||....||.||.||| .||. |||.|.|. | |.|
leqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 326-566 3.2e-52 172.2 In-house 37-234 (392) alignment 
Range on Protein: 326-566
Range on HMM: 37-234/392.0
FQSANLPVNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESGkvkvhrywpg
 ..|. ..|..|||| |.|||| .||.| .   .  |||.|| ||... ..||.||.|.| . .. |||||..... .||.|...  |            
qtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd..........

kqptsignlvvemlhdkqfddyimrefkvtntKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQKCGVQLtAVHCSAGVGRTGVFCAVSILI
                                |    | | |..|| ||| . |     |. .| .|.    .    |  .|||||||||||  ..  ..
................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpl.iihcsagvgrtgvvisidsvv

ERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGE
 . |   |||||. | ..|..|| |||||||| | | .. |
ahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle
0042113 (Phosphotyrosine protein) phosphatases II 327-568 1.2e-84 278.9 In-house 2-243 (245) alignment 
Range on Protein: 327-568
Range on HMM: 2-243/245.0
QSANLPVNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESGKVKVHRYWPGK
..|.||.||.|||| ..||||.|||.|.     ..||||||.|.|||  .. |||||.| |.|..|||||.||... |||||..|.| |.|| ..||| .
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

QPTSIGNLVVEMLHDKQFDDYIMREFKVTNTKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQKCGVQLTAVHCSAGVGRTGVFCAVSILIE
... .|...|..|  ...|||..|...|||.... || |..|... ||| | ||.   |.|..  |........   ..|||||||||||.|.|. ...|
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

RLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYL
.|..|  |.....||.||.||| .||| .||.|.|. | |.|
qlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
0037934 (Phosphotyrosine protein) phosphatases II 327-567 5.3e-78 257.2 In-house 3-241 (243) alignment 
Range on Protein: 327-567
Range on HMM: 3-241/243.0
QSANLPVNKHKNRYANVLPYDDTRVRLtmqavtEGSDYINANYIDGYmsKKaFIATQAPIPDTIPD----FWRMIWEQDCCTIVMLSQEMESGKVKVHRY
  |.||.|..|||| ..||||..||.|      |||||||||.|...  .. .||||.| |.|. |    ||||.||... .|||| ...| |..|...|
siallpenlsknrysdilpydhsrvkl......egsdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPGKQptSIGNLVVEMLHDKQFDDYIMREFKVTNTK-ESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQK-------CGVQLTAVHCSAGVGR
|||..   .|...|..|. ...|||..|.....|.. .  .| |..|....||| | |||   |.|.. .|. ....        .   ..|||||||||
wpgev..tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

TGVFCAVSILIERLkaeaMVDVFQTVKQLREQRPA-MVQTKEQYEFCYQTLGEY
||...|  .....|     ||....||.||||||  .||| .||.|.|. | |.
tGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 327-373 9.3e-09 29.1 In-house 40-86 (440) alignment 
Range on Protein: 327-373
Range on HMM: 40-86/440.0
QSANLPVNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYIDGY
. |.|| || |||| |.| || .|| |        |||||| ||.| 
diaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi
subfamily_PTPRK_pd Subfamily PTPRK 328-565 8.6e-80 262.9 In-house 37-274 (314) alignment 
Range on Protein: 328-565
Range on HMM: 37-274/314.0
SANLPVNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESGKVKVHRYWPGKQ
.|.   |..|||. ..|.|| .||.|.       ||||||..||.|   .|||.|| |...|. ||||......|..||||.. .| |.||  .||| . 
aakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedt

PTsIGNLVVEMLHDKQFDDYIMREFKVTN--TKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQKcGVQLTAVHCSAGVGRTGVFCAVSILI
 .  |.. ||... .   ....| |.|..   . .. |.|||.||..||| . | |  ||..|. .|. .|.. .   . |||||| ||||.|.|..|..
ev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivl

ERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLG
. .. | .||||..||.||.... ||.|.||| |.|. . 
dmieregvvdvfnavktlrsrkvnmveteeqykfiydvil
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 328-373 1.2e-10 35.4 In-house 33-77 (244) alignment 
Range on Protein: 328-373
Range on HMM: 33-77/244.0
SANLPVNKHKNRYANVLPYDDTRVRLTMqAVTEGSDYINANYIDGY
.| | .|  |||| |.||.|.||| |.  .  |||||||||||.| 
navlsanatknryinilpfdetrvilss.skkegsdyinanyiqgs
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 329-576 2.3e-89 293.9 In-house 4-250 (250) alignment 
Range on Protein: 329-576
Range on HMM: 4-250/250.0
ANLPVNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESGKVkVHRYWPGKQP
|. | ||.|||||.....| .|| |  .   . |||||| ...||. .|||||||.|...|| |||||..|..  |||||..  ||.|. .|.||| ...
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka

TSIGNLVVEMLHDKQFDDYIMREFKVTNTKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQKCGVQLTAVHCSAGVGRTGVFCAVSILIERL
.  |.. |..| ...| ||..|..|....|.. .|.|||..|..||| | |.     ..|. .||. ||..| .   |.|||||||.| |.|.. ..|||
ekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerl

KAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYLHSFDPYNN
| | .||||. .|.||..|| .|...||| |.|. . ..| |.. |..
kkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedyar
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 329-566 7.3e-73 240.2 In-house 44-277 (315) alignment 
Range on Protein: 329-566
Range on HMM: 44-277/315.0
ANLPVNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESGKVKVHRYWPGKqP
|.   ||.|||| |...|| .||.| .  . ..|||.|||.||||  |. .||.|.| . .. ||||...|.|. .||||.. .|  | |. .||| |  
akkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.k

TSIGNLVVEMLHDKQFDDYIMREFKVTNtkESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQKCgVQLTAVHCSAGVGRTGVFCAVSILIERL
   |.. | .  ......| .| . |.   ..  | | |...|.|||.| | .   |..|| .|......  |    ||||||||||| |.... .....
viyGkitvtrkseevnteytvrtlsvvf..gdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtns.vgaivvhcsaGvGrtGtfitldavldqa

KAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGE
.|| ..||.. ....|..|  |||. |||.| |..| |
eaenaidvynfitgvrqnrikmvqvaeqyqfiydalle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 329-561 6.1e-59 194.1 In-house 3-234 (239) alignment 
Range on Protein: 329-561
Range on HMM: 3-234/239.0
ANLPVNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYIDGYM-SKKAFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESGKVKVHRYWPGKQ
|.  ||| ||||||.. || .|| |   .    ||||||.|.  |  | ||.||||  .  .  |||||.|..  | ||||.  .|  | |.|.|||   
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

pTSIGNLVVEMLHDKQFDDYIMREFKVTNTKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRwQQKCGVQLTAVHCSAGVGRTGVFCAVSILIER
 .   || | . . . | |||.| | ...  ..  | | ||.|| ||| | |.    .. |  .. . .   | .   .|||||||||| |  .  .. .
.skycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrq

LKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCY
 | .  ||.|. || .||.|| |||| ||| | .
akkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 329-431 6.7e-09 28.9 In-house 22-92 (169) alignment 
Range on Protein: 329-431
Range on HMM: 22-92/169.0
ANLPVNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINAnyidgymskkafiatqapipdtipdfwRMIWEQDCCTIVMLSQEMEsgKvkvHRYWPGKQP
|.| .|. ||| |  |    |||.|       |||||||                           ||||| .   ||.| .  .  |     .|| |. 
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtdd..k...nnfwpeked

TSI
  .
yql
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 329-435 6.7e-09 28.8 In-house 21-95 (169) alignment 
Range on Protein: 329-435
Range on HMM: 21-95/169.0
ANLPVNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINAnyidgymskkafiatqapipdtipdfwRMIWEQDCCTIVMLSQEMEsgKvkvHRYWPGKQP
|.| .|. ||| |  |    |||.|       |||||||                           ||||| .   ||.| .  .  |     .|| |. 
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtdd..k...nnfwpeked

TSIGNLV
  .   |
yqlhpav
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 331-561 7.5e-59 193.8 In-house 4-233 (239) alignment 
Range on Protein: 331-561
Range on HMM: 4-233/239.0
LPVNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYIDGYM-SKKAFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESGKVKVHRYWPGKQpT
  ||| ||||||.. || .|| |   .    ||||||.|.  |  | ||.||||  .  .  |||||.|..  | ||||.  .|  | |.|.|||    .
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.s

SIGNLVVEMLHDKQFDDYIMREFKVTNTKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRwQQKCGVQLTAVHCSAGVGRTGVFCAVSILIERLK
   || | . . . | |||.| | ...  ..  | | ||.|| ||| | |.    .. |  .. . .   | .   .|||||||||| |  .  .. . |
kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk.dslpgarpwvihcsagvgrtgaflvidamlrqak

AEAMVDVFQTVKQLREQRPAMVQTKEQYEFCY
 .  ||.|. || .||.|| |||| ||| | .
kqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 331-568 6.3e-30 99.1 In-house 32-270 (285) alignment 
Range on Protein: 331-568
Range on HMM: 32-270/285.0
LPVNKHKNRYANVLPYDDTRVRLTmqavTEGSDYINANYIDGY-MSKKAFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESGKVKVHRYWPGKQPT
   |   ||||.|   ..||| |         ||| |...      . ..|.|| |.|.|. |||.||...  . ..||   .| |  |.  |.| |   
yeanpdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

S--IGNLVVEM--LHDKQFDDYIMREFKVTNTKESASRV--VRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQKCgvQLTAVHCSAGVGRTGVFCAVSI
   .|.  . .   ...     |.  . |.||....|    . . |   |||  .|.    .|.|   |.. . |   .  .||||||||||  |  .  
vvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpke..kpicvhcsagvgrtatfvgidy

LIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYL
   |.  .  ..... |...|  |   ||.. |. | |  | ||.
atirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 332-569 3.8e-73 241.3 In-house 41-277 (515) alignment 
Range on Protein: 332-569
Range on HMM: 41-277/515.0
PVNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESGKVKVHRYWPGKQPTS-
 .| .|||| |.|||| .||.| .      |||.|| || .. . ||.||.|.| . .. ||||......  ||.|...  |. |.|  .||| |   | 
einfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsv

-IGNLVVEMLHDKQFDDYIMREFKVTntKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQKCGVQLtAVHCSAGVGRTGVFCAVSILIERLK
  |.. ||..  .   . | |...|.  |.. || | |..|| ||| |.|     |. || .|.  ...    |  .|||||||||||....   . . |
kfGsikvelvsleactggikrkltvl..kgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpl.iihcsaGvGrtGvvisidsvvahak

AEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYLH
   |||||..|...|..|| .|||.||| | |... |.|.
ttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_CG42327_pd Subfamily CG42327 332-493 4.2e-30 99.5 In-house 25-191 (319) alignment 
Range on Protein: 332-493
Range on HMM: 25-191/319.0
PV-NKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYIDGYMS-KKAFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESGKVKVHRYWPGKQP-
||  | |.|..||.|  .||| |  ..  . . |..|.|. || . .  .||.|..  |.  ||||..|||   .|| |..  | |  .  .|.| |.  
PvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketl

---TSIGNLVVEMLHDKQFDDYIMREFKVTNTKESASRVVRQYQFtAWPDIGSPDSGGGLIDLIGQVQ
    . |.. | . . .  | |..  . . . ... || .  | .  |.. . | .   || .. .|.
dntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevr
subfamily_CG7180_pd Subfamily CG7180 333-568 2.9e-65 214.9 In-house 41-290 (296) alignment 
Range on Protein: 333-568
Range on HMM: 41-290/296.0
VNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESGKvKVHRYWPGKQPTSIG
 |. |||. .|.||| .|| |.     | |||||| |.|... ||..| |.||  .|. .|||....... ..|.|.....  | ... ||| |. .  |
enreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqyg

NLVVEMLHDKQFDDYIMREFKVTNT----------KESASRVVRQYQFTAWPD-IGSPDSGGGLIDLIGQVQRWQQKC----GVQLTAVHCSAGVGRTGV
...||... ||. .  .|.||.| .           .   |.|...|.| |.     | |  .||.|. .|. |..|       . . |..| |..|.||
eifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGv

FCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYL
..|. . .| .. |  ||||. ||.||..|| .|...|.| ..|..| |..
ylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 333-566 5.2e-57 188.2 In-house 47-277 (439) alignment 
Range on Protein: 333-566
Range on HMM: 47-277/439.0
VNKHKNRYANVLPYDDTRVRLTMQAVTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESGKvkvhrYWPGKQPTSIG
 .. |||| .| ..| ||| |        | |||||||.||  .| .||||.|  .|  ||||...|. . |||||.. .|| |     ||| .. .  |
ydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcyg

NLVVEMLHDKQFDDYIMREFKVTNTKESA--SRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQKCGVQLTAVHCSAGVGRTGVFCAVSILIERLKA
...| . .. .. .|..| ||| | ....   | | |....||||   |     ..|..  ..  ..|  .    |||||||||||   |. | .|.||.
diavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlkl

EAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGE
|  ||.   || ||.||  |||.  || | |... |
enkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 333-558 4.8e-36 119.0 In-house 49-271 (301) alignment 
Range on Protein: 333-558
Range on HMM: 49-271/301.0
VNKHKNRYANVlP-YDDTRVRLtmqaVTEGSD-YINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESGKVKVHRYWPGKQP--
..|.|.|| .| |   .| |..    ...|    | ||.|.     . |||||.|...|  ||| |.   |  .||||.|..|  . | . | | | .  
lpkdkhryptv.PckPstavev....ivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisek

TSIGNLVVEMLHDKQF--DDYIMREFKVTN-TKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQKcgvqlTAVHCSAGVGRTGVFCAVSILI
  ||   ... . ..   .. . |...|.. |.. |.| |  ||.. |.| | | |   | ||.  |.. ..        ||||||.||.  | .  .| 
ldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekP.....ivvhcsaGiGrsvafigteyla

ERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYE
 ...|.  ... ...|.|||.|   |||..|  
reveadptieltealkhlrehrwngvqtnsqly
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 333-559 8.6e-33 108.2 In-house 51-281 (310) alignment 
Range on Protein: 333-559
Range on HMM: 51-281/310.0
VNKHKNRYANVLPYDDTRVRLTMQAVTEgSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESGKVKVHRYWPGKQPTS-I
 . |||||..|.  |..||.|...      ||| |||.     ...|| .| |.  || ||||||... . .|..| . .| |. |.  |||    |   
kymhknrysdvvcldtsrvklkidksry.edyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtety

GNLVVEMLHDkQFDDYIMREFKVTNTKES------A----SRVVRQYQFTAWPDIGSPDSGGGLIdliGQVQRWQQKCGvqLTAVHCSAGVGRTGVFCAV
| . |  | .   ... . .. ||   .               |   ..  ||| | ||     .    |    | . |     ||||||..|..| .|.
gcirvtnlse.sseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtv...pqrllaqvrhg..pcvvhcsagkdrlyvvval

SILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEF
 . |..|.    ||. . . .|. .|   .||. || .
klkidkldrglkvdaeevktellksraiciqtelqyli
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 333-560 1.2e-17 59.0 In-house 18-251 (290) alignment 
Range on Protein: 333-560
Range on HMM: 18-251/290.0
VNKHKNRYANVLpYDDTRVRLTMQAVTEGSDYINANYIDgYMSKKAFIATQAPIPDT-------IPDFWRMIWEQDCCTIVMLSQEMESGKVK----VHR
 .. ..|... |   .||| |        .||| ||..  . .  ..|.||.|  ..       | .|| |. .     .||| . .|  . .      .
khemdqRlevpL.veatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCak

YWPGKQPT--SIGNLVVEMLHDKQFDDYIMREFKVTNTKESASRvVRQYQFTAWPDIGSPDSGGGLIDLIGQVQrwQQKCGVqltAVHCSAGVGRTGVFC
| | .  .   ...| |.  .  . || ..||  |.  .|     |  ...  | ..  ...   |..|| .|.  ..|  |    |||  |. |  .. 
YvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeeft.vtHsllkgWnklnvqedtktllsliqkvk..asktpv...ivHcvdGiSrsAala

AVSILIERLK-AEAMVDVFQTVKQLREQRPAMVQTKEQYEFC
|. .    .   .  | . . .|.||.||  ........ | 
aiilgyQkiaetsgsvkledvlkalrkqralaitsalelafv
Y_phosphatase Protein-tyrosine phosphatase 334-564 2.9e-84 277.5 Pfam-A 1-233 (235) alignment 
Range on Protein: 334-564
Range on HMM: 1-233/235.0
NKHKNRYANVLPYDDTRVRLtmQAVTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESGKVKVHRYWP--GKQPTSI
||.|||| ..||||.|||.|  .  .. ||||||||..|| .||.|||||.|...|| |||||.|.... .|||| ...|.|..|...|||   ..... 
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GNLVVEML-HDK-QFDDYIMREFKVTNTKES-ASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQqKCGVQLTAVHCSAGVGRTGVFCAVSILIERL
|.. ||.  . | . ..|..|.......||. ..| |.|...|.||| | |.|  .|.||| .|.... .   . . |||||||||||.|.|..||.|.|
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

KAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTL
.||  |||.|.||.||.||| |||. |||.|.|...
eaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 334-564 2.9e-84 277.5 In-house 1-233 (235) alignment 
Range on Protein: 334-564
Range on HMM: 1-233/235.0
NKHKNRYANVLPYDDTRVRLtmQAVTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESGKVKVHRYWP--GKQPTSI
||.|||| ..||||.|||.|  .  .. ||||||||..|| .||.|||||.|...|| |||||.|.... .|||| ...|.|..|...|||   ..... 
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GNLVVEML-HDK-QFDDYIMREFKVTNTKES-ASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQqKCGVQLTAVHCSAGVGRTGVFCAVSILIERL
|.. ||.  . | . ..|..|.......||. ..| |.|...|.||| | |.|  .|.||| .|.... .   . . |||||||||||.|.|..||.|.|
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

KAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTL
.||  |||.|.||.||.||| |||. |||.|.|...
eaeeevdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 334-564 8e-58 190.5 In-house 3-235 (237) alignment 
Range on Protein: 334-564
Range on HMM: 3-235/237.0
NKHKNRYANVLPYDDTRVRLtmQAVTEGSDYINANYIDGYM-SKKAFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESGKVKVHRYWPG-KQPTSI
|| ||||.|.  || .|| |  .    |||||||.|..|.  . | .||.| |.  .  |||.|.|.. |  ||||.  .|. ..| |.|||  .||.. 
nkiknrygnivaydhsrvvl..kgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GNLVVEMLHDKQFDDYIMREFKVTNTK-ESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQ-RWQQKCGVQLTAVHCSAGVGRTGVFCAVSILIERLK
| | | . ....| || .| . ...       |.. |||||.||| | |.    |. .  ..  | .         .||||||||||.|  .  .. . |
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

AEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTL
 . .||... |. . |.|| ..|||.|| | .||.
ekkvvdiynyvysieedrpyiiqtkdqyvfihqti
0041856 (Phosphotyrosine protein) phosphatases II 334-568 4.8e-50 165.0 In-house 1-171 (182) alignment 
Range on Protein: 334-568
Range on HMM: 1-171/182.0
NKHKNRYANVLPYDDTRvrltmqavteGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSqemesgkvkVHRYWPgkqptsign
|..|||| ..|||| .|          ..||||||...|..  . |||||.| ..|..||.||..|... |||.|.          ..|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

lvvemlhdkqfddyimrefkvtntkESASRVVRQYQFTAWPDIGSPDsGGGLIDLIGQVQRwqqkcGVQLTAVHCSAGVGRTGVFCAVSILIERlkaeaM
                         |   | . ||... ||| | ||    |.|.| .|..         ..|||||||||||...|  .....      
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl.....g

VDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYL
|.....||..|..|| ||.| .|| |... | |.|
vsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_eak_pd Subfamily eak 334-479 8.6e-16 52.2 In-house 52-195 (332) alignment 
Range on Protein: 334-479
Range on HMM: 52-195/332.0
NKHKNrYANVLPYDDTRVRLTMQAvTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESGKVKVHRYWPGKQ--PTSI
. ..|   ...|||   ||||     .   ||||  ..     . .| | ..  | .. ||.|. ||   .||.| ...| .  |  .|.| |     . 
avnrn.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkf

GNLVVEMLHDKQFDDYIMREFKVTNTKESasRVVRQYQFTAWPDIGSP
| | ||  .  . . . .| ....   |.    |  |..  | ..  |
GildverkefvkrniletrllelskGnet..hrvlhykvfGwtettlp
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 334-417 2.9e-10 34.2 In-house 34-116 (332) alignment 
Range on Protein: 334-417
Range on HMM: 34-116/332.0
NKHKNRYANVLPYDDTRVRLTMQAVTegSDYINANYIDGYMSKKAFIATQAPIPDTI-PDFWRMIWEQDCCTIVMLSQEMESGKV
|   ||   .  .| .|| |. |      |. ||...|||  | |.| .|||. |     ||||. |.    |... .  |  | 
nmdmnriphlycfdhsrvelapqdgk..ddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkr
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 335-574 2e-23 77.5 In-house 44-282 (312) alignment 
Range on Protein: 335-574
Range on HMM: 44-282/312.0
KHKNRYANVLPYDDTRVRLtmqAvTEGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESGKVKVHRYWPGKQ-------
|  ||| |.  .|  |  |   |  .   || ||..      . |..||.|. .|.  ||..     ...|..|.  .| |  |. .|            
kdlnrypniqcwdrgrftl...a.gdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdled

PTSIGNLVVEM-LHDKQFDDYIMREFKVTNTKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQqKCgVqltAVHCSAGVGRTGVFCAVSILIE
     . . |. .  |  |    | .||          . .||...||| | |||      |.  |.. . |  |     |||||||||| .. .  .| 
hrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdk.kp.v...iahcsagvgrtgtlaliesmia

RLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYLHSFDPY
 |.     .| ..   || .|   |..  || .. ... |.|.|   |
alrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgly
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 336-425 4.9e-23 76.4 In-house 49-152 (350) alignment 
Range on Protein: 336-425
Range on HMM: 49-152/350.0
HKNRYANVLPYDDTRVRLT--------MQAVTEGSDYINANYIDGY----MSKKAF--IATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESGKVKVHR
 |||| |.|||. .||.|         ..  ....|||||||.         .  |  ||||||.| |. ||...| . .   |..|....| .  |..|
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPG
||. 
YWqe
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 336-424 1.2e-15 51.7 In-house 50-154 (349) alignment 
Range on Protein: 336-424
Range on HMM: 50-154/349.0
HKNRYANVLPYDDTRVRLTMQ----AVTEG----------SDYINANYID--GYMSKKAFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESGKVKV
 |||| ..|||. .||.|       .|..            |||||||.    .  .| .||||||.| |. ||...|  .    .. |... | .  |.
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

HRYWP
..|| 
diywq
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 344-477 8.4e-10 33.1 In-house 3-125 (130) alignment 
Range on Protein: 344-477
Range on HMM: 3-125/130.0
LPYDDTRVRltmqavteGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESgkvkvHRYWPGKQPTS-IGNLVVEMLHDK
|... .|..        | .||||...      . .. ||.|. ||  |||.|. |.    .|.|    |        |||  .|     . ..  | |.
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdr

QFDDYIMR-EFKVTNTKESASRVVRQYQFTAWPDIG
.  ..|   .... .    . . .  .| . ||  |
defknikasnleiesdlneshqaltmfqisnwpsdg
0044763 (Phosphotyrosine protein) phosphatases II 345-564 2.5e-37 123.6 In-house 1-167 (178) alignment 
Range on Protein: 345-564
Range on HMM: 1-167/178.0
PYDDTRVRLTMQAVTEGSDYINANYIDGYmskkaFIATQAPIpdtiPDFWRMIWEQDCCTIVMLSQEMESGKVKVHRYWPGKQPtsignlvvemlhdkqf
|.|.||| |..   .|.||||||..|...     ......|     .|......|... .||.|..|.| |..| ..||| .                  
pldrtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag................

ddyimrefkvtntkesasrvvRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQKCGvQLTAVHCSAGVGRTGVFCAVSILIERlkaeaMVDVFQTVKQLR
                      ||... .|| | ||.   . ...  ........|   ..|||||||||.|...|  .....      ..... ....|
.....................iqylhipipDhgvpdllehflefvefieealdekg.gpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvr

EQRPaMVQTKEQYEFCYQTL
|.|| .|.. .|....|.  
erRp.ivpnpgqlrqLyefe
0046846 (Phosphotyrosine protein) phosphatases II 352-568 4.4e-46 152.1 In-house 2-173 (176) alignment 
Range on Protein: 352-568
Range on HMM: 2-173/176.0
RLTMQAVTEGSDYINANYIDGYMskkaFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESGKVKVHRYWPGKQPTSIgnlvvemlhdkqfddyimre
||..    ...||||||.|.|..    .||||.|.|.|..||..|..|... ..|.| .|.| |..|...|||  .  .|                    
rlrllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi....................

fkvtntkesasrvvrQYQFTAWPDIGSPDSgGGLIDLIGQVQRWQQKCgvQLTAVHCSAGVGRTGVFCAVSilieRLKAEAMVDVFQTVKQLREQRP-AM
               ||... ||| | ||.   |..|. ........   . ..||||||.||||...|       |. |  ..|.......|||||  .
...............qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplga

VQTKEQYEFCYQTLGEYL
||| |||.|.|. . ..|
vqtpeQyrflyefellll
0043147 (Phosphotyrosine protein) phosphatases II 360-562 2e-45 149.9 In-house 3-155 (172) alignment 
Range on Protein: 360-562
Range on HMM: 3-155/172.0
EGSDYINANYIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEmesgkvkvhrywpgkqptsignlvvemlhdkqfddyimrefkvTNTKE
||||||||.|.|.|   . |||||.| . |..|||||..|... .||.| ..                                           ....|
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

SASRVVRQYQFTAWPDIGSPdSGGGLIDLIGQVQRWQQKCGVQLTAVHCSAGVGRTGVFCAVSILIerlkaeAMVDVFQTVKQLREQRPAMVQTKEQYEF
  .| . ||... ||| | | .   |.... .........    ..|||||||||||...|  ...        ......|...||.|| .||...|| |
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrf

CYQ
.|.
lyy
0051429 (Phosphotyrosine protein) phosphatases II 361-570 2.5e-53 176.8 In-house 3-227 (272) alignment 
Range on Protein: 361-570
Range on HMM: 3-227/272.0
GSDYINANYIDGYMS---KKAFIATQAPIPDTIPDFWRMiWEQDCCTIVMLSQEMESGKVKVHRYWP------------GKQPTSIGNLVVEMLHDKQFD
 |.||||....|| .   .........| | |. ||||. .|... |||.| .|.| |..|..||||            . .. ..|.|.| .|. ....
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DYIMREFKVTNT-KESASRVVRQYQFTAWPDIGSPDSGggLIDLIGQVQRwqqkcgVQLTAVHCSAGVGRTGVFCAVSILIERLKAEAMVD--------V
|||.||. .|.. . ...| |.....|.||| | |..   |..|. ....       .   ||||||..|||...|. .|.... .|..||        .
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

FQTVKQLREQRPAMVQTKEQYEFCYQTLGEYLHS
...|..||.|||..||| |||.|.|. | |.| |
eeaveelraqrpgavqteeqylflyeallellrs
0036282 (Phosphotyrosine protein) phosphatases II 361-562 3e-51 168.8 In-house 1-164 (174) alignment 
Range on Protein: 361-562
Range on HMM: 1-164/174.0
GSDYINANYIDGYMSKKAFIATQAPIPdtipdFWRMIWEQDCCTIVMLSQEMESGKVKVHRYWPGkqptsignlvvemlhdkqfddyimrefkvtnTKES
|||||||...|...  . .||.|.| .     ||.|..|... |.||| .|.| |..|...|||                                ..|.
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lred

ASRVVRQYQFTAWPDIGSPDSGGgLIDLIGQVQRWQQKCGVQLTAVHCSAGVGRTGVFCAVSILIERLKaEAMVDVFQTVKQLREQRPAMVQTKEQYEFC
 .| . ||... ||| | ||.   |.... .|........   ..|||||||||||...|  ... .|. | .||....|..|| ||| |||| .||.|.
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

YQ
|.
yy
0051082 (Phosphotyrosine protein) phosphatases II 361-563 2.1e-35 116.9 In-house 2-148 (151) alignment 
Range on Protein: 361-563
Range on HMM: 2-148/151.0
GSDYINANYIDGYmskkaFIATQAPipdtIPDFWRMIWEQDCCTIVMLSQEMESGkvKVHRYWPGKQptsignlvvemlhdkqfddyimrefkvtntkes
 |||||..|..|.     ......|     .||.....|... |||.| .|.| |  . ..|.|  .                                 
lsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

asRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRwqqkCGVQLTAVHCSAGVGRTGVFCAVSILIERlkaeamVDVFQTVKQLREQRPAMVQTKEQYEFC
  . |...... ||| | |.|   ..... ....    .. . ..||||||.||||...|. .....      |.........|..|| .||...|. |.
..ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfq

YQT
.. 
lfa
0049260 (Phosphotyrosine protein) phosphatases II 369-562 2.7e-40 132.9 In-house 1-144 (152) alignment 
Range on Protein: 369-562
Range on HMM: 1-144/152.0
YIDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESGKVKVHRYWpgkqptsignlvvemlhdkqfddyimrefkvtntkesasrvvrQY
.||||. ...|||||.| | |..|||||..|... ||||| ...| ||.|...|.                                           ||
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

QFTAWPDIGSPDSGGGLIDLIGQVQRWqQKCGVQLTAVHCSAGVGRTGVFCAVSILIerlkaeAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQ
... ||| | ||.   |..|.  .... ..     ..|||||||||||...|  ...        |.....|...||.|| .|....|..|.|.
lhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 370-424 3.9e-10 33.6 In-house 229-280 (440) alignment 
Range on Protein: 370-424
Range on HMM: 229-280/440.0
IDGYMSKKAFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESgkvKVHRYWP
..||  |.|||||| |.  |. ||||.. .    ||.|| |  .     .  |||
fegyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywp
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 371-558 1.9e-16 54.4 In-house 84-278 (302) alignment 
Range on Protein: 371-558
Range on HMM: 84-278/302.0
DGYMSKKAFI-ATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESGKVKVHRYWPGKQPT--SIGNLVVEML---------HDKQFDDYIMREFKVTNTK
||   |.        |  .|.  .| .| . . . .| |.. .|... |.  |.  |       |.  |. .          ||.       |.| ...|
dGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkk

ESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQKCgvqltAVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYE
.   . |   .|.|||| |.|.     .|..   . ....       ||||||||||| . |.   |.  . . . |. . |. .|. |   ||...|  
kkvkktvdilafsawpdhGapkeaytaldilkfcesykknv.....lvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqli
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 376-562 3.3e-24 80.1 In-house 4-198 (199) alignment 
Range on Protein: 376-562
Range on HMM: 4-198/199.0
KKAFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESGKVKVHRYWPGKQPT--SIGNLVVEMLHDKQFDDYIMREFKVTN--TKESASRVVRQYQFT
.. .|||| |. .|. |||.|.||     |||. ..    ..    |||  . .    |.| |         || .  . .||  |   ..| . .||||
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

AWPDIGSPDSG--GGLIDLIGQVQ-RWQQKCGvQLTAVHCSAGVGRTGVFCAVSILIERLK--AEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQ
.| .  .|.     |..    .|  ...|.       |||| | | |||| |. | .   .    ..||.|.  |.||. |  .. . ..|.| ||
swkekttpnvalfvgfvvasrevskkyeqekd.apvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 376-562 3.7e-24 80.0 In-house 3-197 (198) alignment 
Range on Protein: 376-562
Range on HMM: 3-197/198.0
KKAFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESGKVKVHRYWPGKQPT--SIGNLVVEMLHDKQFDDYIMREFKVTN--TKESASRVVRQYQFT
.. .|||| |. .|. |||.|.||     |||. ..    ..    |||  . .    |.| |         || .  . .||  |   ..| . .||||
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

AWPDIGSPDSG--GGLIDLIGQVQ-RWQQKCGvQLTAVHCSAGVGRTGVFCAVSILIERLK--AEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQ
.| .  .|.     |..    .|  ...|.       |||| | | |||| |. | .   .    ..||.|.  |.||. |  .. . ..|.| ||
swkekttpnvalfvgfvvasrevskkyeqekd.apvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 378-477 7.1e-06 19.8 In-house 138-234 (244) alignment 
Range on Protein: 378-477
Range on HMM: 138-234/244.0
AFIATQAPIPDTIPDFWRMIWEQDCCTIVMLSQEMESgkvkvHRYWPGKQPTSI--GNLVVEMLHDKQFDDYIMREFKVTNTKESASRVVRQYQFTAWPD
 .| || |. ||  |||.|. |.    .|.|    |        |||  .|      .. | .    .| .    ....    . . . .  .| . || 
eyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwps

IG
 |
dg
subfamily_hpo-7_pd Subfamily hpo-7 388-564 2.2e-13 44.7 In-house 45-223 (263) alignment 
Range on Protein: 388-564
Range on HMM: 45-223/263.0
DTIPDFWRMIWEQDCCTIVMLSQEMESGKVKVHRYWPGKQPTSIGNLVVEMLHDKQFDDYIMREFKVTNTKE--SASRVVRQYQFTAWPDIGSPDSGGGL
.||. |...|  .   ..|||.   | |..|  .|.| ..        |..   |  .| ...  ....| .     . |..|... |..   |      
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelarei

IDLIgQVQRWQqkcgvQLTAVHCSAGVGRTGVFCAVSILIE----RLKAEA--MVDVFQTVKQLREQRPAMVQTKEQYEFCYQTL
. .. .| |       .   ||||.|.||.  |  . ..       |.      .|  . ...||..|.. ..|  |  |   ..
lnil.kvarns.....kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmv
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 389-567 1.3e-14 48.9 In-house 40-220 (255) alignment 
Range on Protein: 389-567
Range on HMM: 40-220/255.0
TIPDFWRMIWEQDCCTIVMLSQEMESGKVKVHRYWPGKQPTSIGNLVVEMLHDKQFDDYIMREFKVTNTKE--SASRVVRQYQFTAWPDIGSPDSGGGLI
|.  |...|  ..  ..|||.   | |..| ..|.| ..        |..   |   | ..|  ..| |       . |. |... |..  .|.    . 
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

DLIGQVQrwqqKCgvQLTAVHCSAGVGRTGVFCAVSILIE----RLKAE--AMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEY
 ..  |.    .   .   ||||.|.||.  |  . ..       |.    . .|  . ...||..|.. ..|  |  |.  .. ..
nilkvvr....ds..ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldl
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 432-567 4.6e-06 19.5 In-house 174-308 (346) alignment 
Range on Protein: 432-567
Range on HMM: 174-308/346.0
GNLVVEMLHDKQFDDYIMREFKVTNTKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQKCGVQLTAVhCSAGVGRTGVFCAVSILIERLKAE
|.....  .     |      .|    .| | ... .. . |  .  |     .| .| |    .|   . .  |    | ||.  |      |..|   
gkmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapwkhlqqppktlpiikmihqflsekqvqnagvcvv.slfgcgracsfigalyainqlnng

AMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEY
   .... .|....|||  |..  ||   |  . .|
iepniceimknikqqrpggvesfaqyasiyaivfdy
0048076 (Phosphotyrosine protein) phosphatases II 436-566 2.3e-24 81.1 In-house 18-141 (145) alignment 
Range on Protein: 436-566
Range on HMM: 18-141/145.0
VEMLHDKQFDDYIMREFKVTNTKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQKCgvQLTAVHCSAGVGRTGVFCAVSILIErlkaeAMVD
. .  .   |  | . . .|...|  .| . ||... ||| | ||.   |.... ........     ..|||||||||||...|  ....       |.
taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmll.....lgvs

VFQTVKQLREQRPAMVQTKEQYEFCYQTLGE
........|.||| .|.. .|..|.|. . |
leealelvrsqrpgavpnpgqlrflyefele
0048179 (Phosphotyrosine protein) phosphatases II 456-562 2.6e-22 74.5 In-house 40-139 (144) alignment 
Range on Protein: 456-562
Range on HMM: 40-139/144.0
NTKESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQKCgvQLTAVHCSAGVGRTGVFCAVSILIerlkAEAmVDVFQTVKQLREQRPAMVQTKE
  .|.  | . ||... ||| | ||.   |....  .......     ..|||||||||||...|  ...     .  ..........|..|| .|.. .
yepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpg

QYEFCYQ
|..|...
qlrfLle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 459-568 3.6e-23 76.6 In-house 85-194 (440) alignment 
Range on Protein: 459-568
Range on HMM: 85-194/440.0
ESASRVVRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQKCGVQLTAVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYE
   ||...||.. .||| | |   | .. .| .|.  |.|.|     ||||||.|||||  ||  ..   |    .|.|  .. .|..|| |||| ||| 
giesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqya

FCYQTLGEYL
| .... | |
fvheavlegl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 464-567 8.7e-15 49.3 In-house 216-343 (350) alignment 
Range on Protein: 464-567
Range on HMM: 216-343/350.0
VVRQYQFTAWPDI---GSPDSGGGLID----LIGQ--VQRWQQKCGVQLTAVHCSAGVGRTGVFCAVSILIE-------------RLKAEAMV--DVFQT
|| | |.  |.|.     | |    ..    || .   . . ..   .   |||||||||||.....  |..             .|.  |..   ....
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

VKQLREQRPAMVQTKEQYEFCYQTLGEY
|..||.||  |||...|. |.|..|  |
vnelrkqrismvqnldqfifiYeallfy
PTPc_DSPc_SM00012 465-564 6.8e-35 114.8 In-house 2-103 (105) alignment 
Range on Protein: 465-564
Range on HMM: 2-103/105.0
VRQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQKCGV-QLTAVHCSAGVGRTGVFCAVSILIERLKAE-AMVDVFQTVKQLREQRPAMVQTKEQYEFCYQ
|..|..|.||| | |...  ...|. .|.....|..  . . |||||||||||.|.|..||...|..|   ||.||.||.||.||| ||||.||| |.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

TL
 |
al
0038934 (Phosphotyrosine protein) phosphatases II 466-568 4.3e-11 38.3 In-house 80-177 (194) alignment 
Range on Protein: 466-568
Range on HMM: 80-177/194.0
RQYQFTAWPDIGSPDSGGGLIDLIGQVQRWQQKCGVQLTAVHCSAGVGRTGVFCAVsILIERLKAeamvDVFQTVKQLREQRPAMVQTKEQYEFCYQTLG
 .|    .|| |.. |   | . .  |... ...  .. |||| ||.||||...|   ||.||.     .. . .. .|| || .... ...|  ..  .
ieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa.YLiyrlgm....saeeAialfrekRpgaipnqdyleallkryk

EYL
|. 
elr
subfamily_PTPDC1_pd Subfamily PTPDC1 468-562 1.1e-11 39.6 In-house 86-170 (182) alignment 
Range on Protein: 468-562
Range on HMM: 86-170/182.0
YQFtAWPDIGSPdSGGGLIDLIGQVqrwQQKCGVQLTAVHCSAGVGRTGVFCAVSI-LIERLKAEamvdvfQTVKQLREQRPAMVQTKEQYEFCYQ
|.| .|.| |.. |   ..|..  |   .. .  . .|||| || |||||  |. .   .||.||      ...| .|..||  .||.|| |.. .
ynf.gwkDygva.sleriLdivkvv...afalqegkvavhChaGlGrtGvliacylvyakrltae......kaiklvrskrpksiqtreqvelvke
subfamily_PTEN_pd Subfamily PTEN 484-556 2.1e-07 26.1 In-house 97-168 (184) alignment 
Range on Protein: 484-556
Range on HMM: 97-168/184.0
GLIDLIGQVQRWQQKCGVQLTAVHCSAGVGRTGVFCaVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQ
 | ... ....| ..   .. .||| || |||||   |. |...|. | . .. .  .. | .    |.   |
lleeivediekwleedkknvvvvHCkaGkGRtGvli.vayllkslllekaeealelfaeaRtknkkgvtiPsq
PTEN_1 490-561 1.6e-06 23.0 In-house 118-186 (196) alignment 
Range on Protein: 490-561
Range on HMM: 118-186/196.0
GQVQRWQQKCG-VQLTAVHCSAGVGRTGVFCAvSILIERLKaeamVDVFQTVKQLREQR-PAMVQTKEQYEFCY
 ..  | ...      .||| ||.||.|. .| . |... |     .. .... .||.| |..... .| .. .
ksfiewllsdpngnvVlVHCkaGlgRsGtvva.ayLmykgk....ltadeAlelvrekRppgapnspsqerlle
subfamily_PRL_pd Subfamily PRL 495-551 6.2e-06 20.3 In-house 85-134 (151) alignment 
Range on Protein: 495-551
Range on HMM: 85-134/151.0
WQQKCGvQLTAVHCSAGVGRTGVFCAVSILIERLKAEAMVDVfqtvkqLREQRPAMV
.... . .  |||| ||.||. |. |.... . .| |  |..      .||.| . .
fkeepk.stvavhcvaGlGraPvlvalalieaGmkyedavef......irekrrgai
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 500-568 2e-10 34.5 In-house 264-344 (349) alignment 
Range on Protein: 500-568
Range on HMM: 264-344/349.0
GVQLTAVHCSAGVGRTGVFCAVSILIE----------RLKAEAMV--DVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYL
 .    |||||| |||||.. . .|..          ..| .|.    .. .| .|| || .|||   |. ..|..| .|.
qlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 503-563 3.9e-16 53.8 In-house 230-290 (297) alignment 
Range on Protein: 503-563
Range on HMM: 230-290/297.0
LTAVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQT
 . |||||||||.||     .....|. . . ||   ...|||||. .||| ||.|..|. 
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyda
subfamily_DSP23_pd Subfamily DSP23 504-562 3.7e-06 21.6 In-house 87-140 (148) alignment 
Range on Protein: 504-562
Range on HMM: 87-140/148.0
TAVHCSAGVGRTGVFCAVSILIERLKAEAmvdvfQTVKQLREQRPAMVQTKEQYEFCYQ
 .|||  | |||| . |  .. ||  | |     ... ..|..||  |.| || .  ..
vsvhcllgrgrtgtmlacylvkerklaaa.....eaiaevrrlrpgsvetveqeklvrd
subfamily_CG42327_pd Subfamily CG42327 505-567 1.3e-16 55.2 In-house 251-314 (319) alignment 
Range on Protein: 505-567
Range on HMM: 251-314/319.0
AVHCSAGVGRTGVFCAVSILIERLKAE-AMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEY
.|||| ||||||.  |  | |..|.     ||. |.| ..|..|   |.||||||| |..| ||
vvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 505-568 3.7e-16 53.3 In-house 2-65 (69) alignment 
Range on Protein: 505-568
Range on HMM: 2-65/69.0
AVHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYL
 ||||.| |||| | |. . . |.|.| .||.|  |. .|  || ||  . .| | . .| | |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 506-568 3e-16 53.5 In-house 2-64 (69) alignment 
Range on Protein: 506-568
Range on HMM: 2-64/69.0
VHCSAGVGRTGVFCAVSILIERLKAEAMVDVFQTVKQLREQRPAMVQTKEQYEFCYQTLGEYL
||||.| |||| | |. . . |.|.| .||.|  |. .|  || ||  ...| | ...| | |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
subfamily_ptpA1_pd Subfamily ptpA1 534-565 1.6e-07 25.4 In-house 364-395 (418) alignment 
Range on Protein: 534-565
Range on HMM: 364-395/418.0
VDVFQTVKQLREQRPAMVQTKEQYEFCYQTLG
...|  | .|||||| |||  ||| |||.|. 
fnlfsivlklreqrpgmvqqleqylfcyktil