Gene DSP1 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP1
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP008_AA protein Get Run
SpurP008_AA_174-314 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Rhodanese Rhodanese-like domain 25-134 1e-07 24.5 Pfam-A 13-111 (113) alignment 
Range on Protein: 25-134
Range on HMM: 13-111/113.0
RVLLLDCRSFVCYNSLHIVDALNVHCPLLlkrRSNGPLPVDHLVTCADARSRLLAGFYQAVLVYDeesvqtASEVSQGNMTWV-LETLFQE---Pllqls
.|.|||.||.  |.  ||  |.||  ..|   .....|. .   .   ..|    .  . |.||.      .|  ..|..... |. ...|   .     
kvvllDvRspeeyakghIpgAvnvpldsl...yprrdlffkdklaeeleesgkkldkdktvvvyc......rsgnrsggaaalllalilkelgyk.....

vKIFSLVGGFNQFS
 ... | |||....
.nvyvLdGGfeawk
0037934 (Phosphotyrosine protein) phosphatases II 168-313 2.7e-31 104.4 In-house 30-240 (243) alignment 
Range on Protein: 168-313
Range on HMM: 30-240/243.0
SGPGYECNAPVRLLPHLYLGSN--------FHASRLAVLEEHGITAVLNVSR----------------------------------------------LP
.| .| .   .. .|.|....          .|| .  | |.|||..... .                                              |.
egsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldld

NYFPTCFRYMQILVDD----NTDADLLPWFEEANNFIDS-----IERCKGRVLVHCHAGISRSATICLAYLMKVR-QIRLEEAFEFVRSERTV-ISPNLA
... . ..|... . |    .. .||| ...|...||..      .  .|.|||||.||..|..|...||||. . .. ||||....|. |   . ... 
dltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtps

FMLQLLRFENE
.. .| ... |
qyrflyealle
0044763 (Phosphotyrosine protein) phosphatases II 171-313 1.5e-40 134.1 In-house 17-169 (178) alignment 
Range on Protein: 171-313
Range on HMM: 17-169/178.0
GYECNAPVRLLPHLYLGSNFHASRLAVLEEHGITAVLNVSRLP-NYFPTC---------FRYMQILVDDNTDADLLPWFEEANNFIDSIE-RCKGRVLVH
..... ... ||.|||||  .|. |. | |.|||...|..    ..|. |         ..|..| ..|... ||| .|.|. .||...  ...|.||||
rsdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVH

CHAGISRSATICLAYLMKVRQIRLEEAFEFVRSERTvISPNLAFMLQLLRFENE
|.||..||.|...|||||.... ||||.|.||. |  |.||  .. ||..|| .
CsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelr
subfamily_DSP1_pd Subfamily DSP1 172-313 1.7e-61 201.0 In-house 15-155 (163) alignment 
Range on Protein: 172-313
Range on HMM: 15-155/163.0
YEcnaPVR-LLPHLYLGSNFHASRLAVLEEHGITAVLNVSR-LPNYFPTCFRYMQILVDDNTDADLLPWFEEANNFIDSIERCKGRVLVHCHAGISRSAT
|.   ||. .|..|||||. .||.| .|...||||.||||. |.|.|...|.|... ..|...||.  .|||. .|||......|.||.||.||||||.|
yd...PvekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsst

ICLAYLMKVRQIRLEEAFEFVRSERTVISPNLAFMLQLLRFENE
.||||||| ....|||||.||...|..||||..|.||||..|..
lclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekk
subfamily_DSP10_pd Subfamily DSP10 174-314 1.7e-48 158.5 In-house 11-153 (159) alignment 
Range on Protein: 174-314
Range on HMM: 11-153/159.0
CNAPVRLLPHLYLGSNFHASRLAVLEEHGITAVLNVS-RLPNYFPT-CFRYMQILVDDNTDADLLPWFEEANNFIDSIERCKGRVLVHCHAGISRSATIC
    ...||.|.|||.  |. |..|....|||||||  ..||.|    ..|..| | |..  .|   |||| .||. . ..  ||||||.||||||||. 
tapasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvv

LAYLMKVRQIRLEEAFEFVRSERTVISPNLAFMLQLLRFENEL
.||||| ... |..|..||.. |..|||||.|| |||.||.||
iaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekel
subfamily_DSP6_pd Subfamily DSP6 174-314 5.6e-46 149.9 In-house 11-154 (158) alignment 
Range on Protein: 174-314
Range on HMM: 11-154/158.0
CNAPVRLLPHLYLGSNFHASRLAVLEEHGITAVLNVS-RLPNYFPTC--FRYMQILVDDNTDADLLPWFEEANNFIDSIERCKGRVLVHCHAGISRSATI
 ..||..||.|||||. .|| | ||....|  ||||   ||| |     ..|.|| ..|.  ..|  .| || .|||   . |  |||||.|||||| |.
aefpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtv

CLAYLMKVRQIRLEEAFEFVRSERTVISPNLAFMLQLLRFENEL
.|||||| ... |..|...|.. .. ||||. || ||| ||..|
tlaylmkklalslndaydlvkkrksnisPnfnfmgqlldfersl
0045098 (Phosphotyrosine protein) phosphatases II 174-313 1.4e-29 98.8 In-house 19-270 (278) alignment 
Range on Protein: 174-313
Range on HMM: 19-270/278.0
CNAPVRLLPHLYLGSNF-----------------------------------------HASRLAVLEEHGITAVLNV-----------------------
.. | . .|.||||.                                           .|. .  | |.|||.....                       
lgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggslty

------------------------------SRLPNYFPTCFRYMQILVDDNTDADLLPWFEEANNFIDSIER--------------CKGRVLVHCHAGIS
                              . |.... | . |. .   .  . ..| .| |. .||..  .               .|.|||||.||..
gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvg

RSATICLAYLMKVR---QIRLEEAFEFVRSERTV-ISPNLAFMLQLLRFENE
|..|...||||. .   .. |.||....|| |   . .|| .. .| .|. |
RtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyeflle
subfamily_Slingshot_pd Subfamily Slingshot 175-311 1.3e-39 129.3 In-house 17-154 (169) alignment 
Range on Protein: 175-311
Range on HMM: 17-154/169.0
NAPVRLLPHLYLGSNFHASRLAVLEEHGITAVLNVSR-LPNYFPTCFRYMQILVDDNTDADLLPWFEEANNFIDSIERCKGRVLVHCHAGISRSATICLA
... ..  |.||||.. || |  |.|.|.. .|||.. . |.||  |.|..| | |. ..|||....|. .||.   . . .|||||  |.||||.. .|
dsaskifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastvia

YLMKVRQIRLEEAFEFVRSERTVISPNLAFMLQLLRFE
| ||  .. ||||.|.|...|.|| || .|. ||  .|
yamkeyglsleealeyvkerrsvikPnkgflkqleeye
subfamily_DSP8_pd Subfamily DSP8 176-314 6.3e-41 133.6 In-house 14-154 (159) alignment 
Range on Protein: 176-314
Range on HMM: 14-154/159.0
APVRLLPHLYLGSNFHASRLAVLEEHGITAVLNVSRLPNYFP--TCFRYMQILVDDNTDADLLPWFEEANNFIDSIERCKGRVLVHCHAGISRSATICLA
 | |.|..|||||. ..    .|.. ||. |||.|.        .  ..... | |. | .|||||... .||| . . .||||||..||||||||. .|
gptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaia

YLMKVRQIRLEEAFEFVRSERTVISPNLAFMLQLLRFENEL
|.||  .. |.||..||.. |..||||| |. ||| .|.||
yimktlemsldeayrfvkekrptispnlnflgqLleyekel
subfamily_LRR-DSP_pd Subfamily LRR-DSP 176-314 2.8e-36 119.0 In-house 119-258 (263) alignment 
Range on Protein: 176-314
Range on HMM: 119-258/263.0
APVRLLPHLYLGSNFHASRLAVLEEHGITAV-LNVSRLPNYFPTCFRYMQI-LVDDNTDADLLPWFEEANNFIDSiERCKGRVLVHCHAGISRSATICLA
 |  ....|.||.   |   ..|.. |.| . | |. .  .||  |.|. |  ..|  .||.  .||| | ||..  | || ||||| ||.|||.|. ..
vPdeiidklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafiee.GrkkGGvlvhcraGvsrsstlvis

YLMKVRQIRLEEAFEFVRSERTVISPNLAFMLQLLRFENEL
|||| ......||...| ..|. | ||  |. ||...|..|
ylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekkl
0043147 (Phosphotyrosine protein) phosphatases II 176-313 8.9e-36 118.6 In-house 18-159 (172) alignment 
Range on Protein: 176-313
Range on HMM: 18-159/172.0
APVRLLPHLYLGSNFHASRLAVLEEHGITAVLNVSR----LPNYFPTCFRYMQILVDDNTDAdLLPWFEEANNFIDS--IERCKGRVLVHCHAGISRSAT
 | |.........| .|. .. | |.|||...|. .     ...... ..|. . ..|..   || ...|. .|||.  ... .|.|||||.||..|..|
ipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgt

ICLAYLMKvRQIRLEEAFEFVRSERTVISPNLAFMLQLLRFENE
...||||. ... ||||...||. |  ...|  .. .|. ||. 
lvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekl
PTPc_motif_SM00404 177-312 4e-44 144.9 In-house 2-139 (140) alignment 
Range on Protein: 177-312
Range on HMM: 2-139/140.0
PVRLLPHLYLGSNFHASRLAVLEEHGITAVLNVSRLPN--YFPTCFRYMQILVDDNTDADLLPWFEEANNFIDSIERCKGRVLVHCHAGISRSATICLAY
| | ||||||||. .|...|.|...|||.|.||..  .  .    |...|| .|||. ..|.........||...|. .|.||||| ||.|||||...||
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

LMKVRQIRLEEAFEFVRSERTVISPNLAFMLQLLRFEN
||. ||. |.||.|||...|  ||||| |. ||. .|.
lmryrqlslaeayefvkerRpiispnlnfvrqLieyek
0048076 (Phosphotyrosine protein) phosphatases II 177-313 8.9e-36 118.1 In-house 4-141 (145) alignment 
Range on Protein: 177-313
Range on HMM: 4-141/145.0
PVRLLPHLYLGSNFHASRLAVLEEHGITAVLNV-SRLPNYFPTCFRYMQILVDDNTDADLLPWFEEANNFIDSIERCKGRVLVHCHAGISRSATICLAYL
| . ||.|||||  .|..|. |...|||.|||. | |...... ..|... ..|..  ||| ...|. .||... . .|.|||||.||..|..|...|||
pseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaayl

MKVRQIRLEEAFEFVRSERTVISPNLAFMLQLLRFENE
|. ... ||||.|.||| |  . ||  .. .|..|| |
mlllgvsleealelvrsqrpgavpnpgqlrflyefele
0041856 (Phosphotyrosine protein) phosphatases II 177-311 1.1e-35 118.3 In-house 19-169 (182) alignment 
Range on Protein: 177-311
Range on HMM: 19-169/182.0
PVRLLPHLYLGSNFH--------------ASRLAVLEEHGITAVLNVSrLPNYFPTCF-----RYMQILVDDNTDADllpwFEEANNFIDSIERCKGRVL
. . ...|||||  .              |. |  | |.|||...|..  ..|.|. .     .|... ..|..  |    ..|...||. ... .|.||
ldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggpvl

VHCHAGISRSATICLAYLMKVRQIRLEEAFEFVRSERT--VISPNLAFMLQLLRFE
|||.||..|..|...|||||.... ||||...||| |   ||.||  |.|||. .|
VHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlalle
0048179 (Phosphotyrosine protein) phosphatases II 177-313 6.9e-35 115.2 In-house 4-143 (144) alignment 
Range on Protein: 177-313
Range on HMM: 4-143/144.0
PVRLLPHLYLGSNFHASRLAVLEEHGITAVLNVSR-LPNYFPTCF--RYMQILVDDNTDADLLPWFEEANNFIDSIERCKGRVLVHCHAGISRSATICLA
|.. ||.|||||  .|..|. | ..|||.|.|..   ...|....  .|... ..|.   ||| ...|. .||... . .|.|||||.||..|..|...|
pseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaa

YLMKVRQIRLEEAFEFVRSERTVISPNLAFMLQLLRFENE
||||.... ||||...||| |  . ||  .. .||..|..
ylmkklglsleealalvrsrrpgavpnpgqlrfLleyekl
0046846 (Phosphotyrosine protein) phosphatases II 177-313 2.6e-31 104.1 In-house 12-171 (176) alignment 
Range on Protein: 177-313
Range on HMM: 12-171/176.0
PVRLLPHLYLGSNF----------HASRLAVLEEHGITAVLNVSRL--------PNYFPT----CFRYMQILVDDNTDADLlPWFEEANNFIDSIERCKG
.......|.||| .          .|. |. | |.|||||.|.  .        |||.|      ..|... ..|..  ||  ...|. .||..  . .|
ldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkegg

RVLVHCHAGISRSATICLAYLMKV-RQIRLEEAFEFVRSERT-VISPNLAFMLQLLRFENE
.|||||.|||.|..|...|||..  ... .|||...||. |   . .. ... .| .|| .
pvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefell
0049260 (Phosphotyrosine protein) phosphatases II 177-312 3.6e-31 103.3 In-house 8-147 (152) alignment 
Range on Protein: 177-312
Range on HMM: 8-147/152.0
PVRLLPHLYLGSNFHASRLAVLEEHGITAVLNVSRLPN----YFPTCFRYMQILVDDNTDADLLPWFEEANNFIDS-IERCKGRVLVHCHAGISRSATIC
| . ......|.| .|. .  | |.|||..... .|      ...  ..|... ..|..  ||  ...... ||.  ... .|.|||||.||..|..|..
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlv

LAYLMKvRQIRLEEAFEFVRSERTVISPNLAFMLQLLRFEN
.||||. ... ||||...||. | .. ||  .. .|. ||.
aaylml.lgvsleeavalvrekRpgavpnpgqlrflyefek
subfamily_STYXL1_pd Subfamily STYXL1 177-313 1.4e-24 80.1 In-house 11-152 (157) alignment 
Range on Protein: 177-313
Range on HMM: 11-152/157.0
PVRLLPH-LYLGSNFHASRLAVLEEHGITAVLNVSRLPNYFPT----CFRYMQILVDDNTDADLLPWFEEANNFIDSIERCKGRVLVHCHAGISRSATIC
|| .||. ||||   .|   |. ..  . |..|||   . . .    . . ..| |.|. .||||. ..|| .||.. .. .  |||  . ||||||.. 
PvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaavi

LAYLMKVRQIRLEEAFEFVRSERTVISPNLAFMLQLLRFENE
.||||  ..| |..|.....  .  . || ||. || ..|..
iaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekq
subfamily_DSP14_pd Subfamily DSP14 178-314 2.7e-40 131.9 In-house 8-144 (157) alignment 
Range on Protein: 178-314
Range on HMM: 8-144/157.0
VRLLPHLYLGsNFHASRLAVLEEHGITAVLNVS-RLPNYFPTCFRYMQILVDDNTDADLLPWFEEANNFIDSIERCKGRVLVHCHAGISRSATICLAYLM
... |.|.|.    |.. ..|....||...||. .|||     ...... |.||..|.| ..|.|. . |..... .|..|||| ||.||||..||||||
sqitpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylm

KVRQIRLEEAFEFVRSERTVISPNLAFMLQLLRFENEL
| ... |.||.. |.| | .|.||. |  || ..|..|
kyeklsLreayklvksaRpiirPNvGFwkqlidyEkkl
0049772 (Phosphotyrosine protein) phosphatases II 178-313 3e-31 104.7 In-house 155-272 (314) alignment 
Range on Protein: 178-313
Range on HMM: 155-272/314.0
VrllphlylgSNFHASRLAVLEehgitavlNVSRLPNYFPTC-FRYMQILVDDnTDADLLPWFEEANNFIDSIeRCKGRVLVHCHAGISRSAT-ICLAYL
          .  .|..|. |.        ..   |..|.   ..|..| |.|  .|.|| .|.|. .||..  . .|.|||||.||..|..| ...|||
g.........neptaadlellk........eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaayl

MKVRQIRLEEAFEFVRSERTvISPNLAFMLQLLRFENE
|| ... ||||.|.||. |. |.||  |. ||...|..
mkllgvsleealedvrlkRp.inpnpgfieqleqyefi
0051429 (Phosphotyrosine protein) phosphatases II 178-313 1.4e-22 76.1 In-house 17-223 (272) alignment 
Range on Protein: 178-313
Range on HMM: 17-223/272.0
VRLLPHLYLGSNF----HASRLAVLEEHGITAVLNVSRLP-------NYFPTCFRYMQILVDDNTDADLLPWF---------------------------
 ...|.... |..     |  .. |.|.||...... ..         ...  .||... . |... . | ..                           
rvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsa

---------------------EEANNFIDSIERcKGRVLVHCHAGISRSATICLAYLMKvRQIR--------------LEEAFEFVRSERTVISPNLAFM
                     |.  .... . . .|.|||||.||..|..|.....|.  ...               |||| | .|. |  . .. ...
gearevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqy

LQLLRFENE
|.|.... |
lflyealle
subfamily_DSP19_pd Subfamily DSP19 179-313 6.3e-41 134.2 In-house 14-149 (152) alignment 
Range on Protein: 179-313
Range on HMM: 14-149/152.0
RLLPHLYLGSNFHASRLAVLEEHGITAVLNVS-RLPNYFPTCFRYMQILVDDNTDADLLPWFEEANNFIDSIERCKGRVLVHCHAGISRSATICLAYLMK
 . |.|||||   |.    |.|..|| .|||.  .|| ||. | |..| . |. ..||| ...|| .||..  . .|.|||||.||.||||.. .|||||
eveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmk

VRQIRLEEAFEFVRSERTVISPNLAFMLQLLRFENE
 ....||||.| ||. |  |.||  |. || ..|.|
keelsleealelvrearpcikPneGFikqLkeyeae
PTEN_1 179-314 2.3e-35 117.2 In-house 43-191 (196) alignment 
Range on Protein: 179-314
Range on HMM: 43-191/196.0
RLLPHLYLGSNFHASR-LAVLEEHGITAVLNVSRLPN----------YFPTCFRYMQILVDDNTDADLLPWFEEANNFIDSIER--CKGRVLVHCHAGIS
.. ..||.||  .... |  |.|.|||.|.|.|  ..          .|   ..| .. ..| .  .|  .|.....||... .  ... |||||.||..
eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlg

RSATICLAYLMKVRQIRLEEAFEFVRSERTVISPNLAFMLQLLRFENEL
||.|.. ||||. ..   .||.|.||. |....|| ... .||....||
RsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfael
subfamily_DSP12_pd Subfamily DSP12 179-311 2.4e-35 116.2 In-house 4-140 (155) alignment 
Range on Protein: 179-311
Range on HMM: 4-140/155.0
RLLPHLYLGSNFHASRLAVLEEHGITAVLNVSRLP--N--YFPTCFRYMQILVDDNTDADLLPWFEEANNFIDSIERCKGRVLVHCHAGISRSATICLAY
|.|| ||||.  .. . . |.| .||.|| | . .  .    ..  .. .| ..|. ..|.| ...||..||..    .| |||||.||.|||.||..||
rilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAY

LMKVRQIRLEEAFEFVRSERTVISPNLAFMLQLLRFE
|||  .. ||.|...|.. .  |.||  |. ||  ||
lmkkeklslekAlklvkekkpeiepNegFleQLklfe
0036282 (Phosphotyrosine protein) phosphatases II 179-311 4.3e-27 90.3 In-house 14-166 (174) alignment 
Range on Protein: 179-311
Range on HMM: 14-166/174.0
RLLPHLYLGSNFHAsRLAVLEEHGITAVLNVSRLP----------------NYFPTCFRYMQILVDDNTDADLLPwFEEANNFIDSIERC--KGRVLVHC
. .|.|..|.  .|  .. | |.|||.|... ..                  . .. ..|... ..|..  ||   ..|. .|....     .| |||||
yitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHC

HAGISRSATICLAYLMKVRQI-RLEEAFEFVRSER---TVISPNLAFMLQLLRFE
.||..|..|...||||..... .|..|...||. |     . ..  .. .|  ||
saGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfe
0042113 (Phosphotyrosine protein) phosphatases II 179-313 1.7e-26 88.6 In-house 49-241 (245) alignment 
Range on Protein: 179-313
Range on HMM: 49-241/245.0
RLLPHLYLGSNFHASRLA----VLEEHGITAVLNVSR-----------------------------------------------LPNYFPTCFRYMQILV
|  |......  ... ..     | |.|||.......                                                 ..  ....|... .
ritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpw

DDNTDADLLPWFEEANNFIDSIER--CKGRVLVHCHAGISRSATICLAYLM-----KVRQIRLEEAFEFVRSERTVISPNLAFMLQLLRFENE
.|.. .||| ..... .|.... .   .|.|||||.||..|..|...||||     | . . ||||....|| |  . ... .. .| ... |
pdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
0036941 (Phosphotyrosine protein) phosphatases II 179-313 1.9e-23 78.6 In-house 21-275 (297) alignment 
Range on Protein: 179-313
Range on HMM: 21-275/297.0
RLLPHLYLGSNFHASRLAVLE----------------------------------------------------------EHGITAVLNVSRLP-------
.|||.|.|||  .|.... ||                                                          |...| ......|        
ellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekc

-NYFPTC----------------------------------------FRYMQILVDDNTDADLLPWFEEANNFIDSIER------CKGRVLVHCHAGISR
  |.|.                                         .. ... . .  | .. .....  .||. ...       .|.|||||.||..|
aqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgR

SATICLAYLM--------KVRQIRLEEAFEFVRSERTVISPNLAFMLQLLRFENE
|.|...|.||        | ... . ||. ..|. |  . ..| ....| ... |
sgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyealle
subfamily_DSP15_pd Subfamily DSP15 180-312 4.5e-33 108.5 In-house 5-137 (151) alignment 
Range on Protein: 180-312
Range on HMM: 5-137/151.0
LLPHLYLGSNFHASRLAVLEEHGITAVLNVSRLPNYFPTCFRYMQILVDDNTDADLLPWFEEANNFIDSIERCKGRVLVHCHAGISRSATICLAYLMKVR
.|| ||||    ..  . |.|. || .|.|.  .. .   ..|  | ..| ..|.|  .|.|...|| .    .. ||||| ||.|||.|.. |||| | 
vlpglylgnfrdskdeelLkeknithilsvhdnakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtvt

QIRLEEAFEFVRSERTVISPNLAFMLQLLRFEN
..  ..|.|... .|.|  ||. |  ||  .|.
elnwrdalevikaaRsvanPnfGfkrqlkeyek
subfamily_DSP3_pd Subfamily DSP3 180-314 1.3e-31 103.5 In-house 14-157 (162) alignment 
Range on Protein: 180-314
Range on HMM: 14-157/162.0
LLPHLYLGSNFHASRLAVLEEHGITAVLNVSRL--------PNYFP-TCFRYMQILVDDNTDADLLPWFEEANNFIDS-IERCKGRVLVHCHAGISRSAT
  |.||.| .  |.    |.. ||| ||| ..         ....  . ..|. . |||.  .||  .||.| .|||. ... .|.|||||..|.|||||
vypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsat

ICLAYLMKVRQIRLEEAFEFVRSERTvISPNLAFMLQLLRFENEL
. ||||| .|.. | || . ||..|. | ||  |. ||  ...||
lvlayLmirrkmtlveairtvrkkRe.ilPneGFlkqLaeldeel
0040439 (Phosphotyrosine protein) phosphatases II 180-313 1.3e-30 102.2 In-house 32-244 (249) alignment 
Range on Protein: 180-313
Range on HMM: 32-244/249.0
LLPHLYLGSNFHASRLAV------------------------LEEHGITAVLNVSRLPN-----------------------------------------
 || |.|..  .|| . .                        | |.|||.......|                                           
ilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtlel

---YFPTCFRYMQILVDDNTDADLLPWFEEANNFIDSIER------CKGRVLVHCHAGISRSATICLAYLM-----KVRQIRLEEAFEFVRSERTVISPN
   |... .....| . |  | .. |.||.. .||. ..       ..|.|||||.||..|..|...||||     | ... ||||....|| |  . .|
tnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqn

LAFMLQLLRFENE
. .. .|.... |
peqyrflyealle
subfamily_STYX_pd Subfamily STYX 180-312 7.9e-27 87.4 In-house 15-155 (166) alignment 
Range on Protein: 180-312
Range on HMM: 15-155/166.0
LLPHLYLGSN--FHASRLAVLEEHGITAVLNVSRLP------NYFPTCFRYMQILVDDNTDADLLPWFEEANNFIDSIERCKGRVLVHCHAGISRSATIC
.|| |.||       |.| ||..|||| .. . . .        ||  |||. . | |||  ... .. .  .|||.  .  |.||||  |||||||.. 
ilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalv

LAYLMKVRQIRLEEAFEFVRSERTVISPNLAFMLQLLRFEN
.||.|.   ..  ||| .|.  |  |.||  |. ||  .| 
iayimetyglkyreafayvqerrfcinpnegfvsqlkeyea
0051082 (Phosphotyrosine protein) phosphatases II 180-308 2.5e-26 87.5 In-house 11-147 (151) alignment 
Range on Protein: 180-308
Range on HMM: 11-147/151.0
LLPHLYLGSNFHASRLAVLEEHGITAVLNVSR------LPNYFPT-CFRYMQILVDDNTDADLLPWFEEANNFIDSIERC-KGRVLVHCHAGISRSATIC
. ..||...  .|  |. |.|.||....|.        .|.|.|   .....| ..|..| .|  .|.....|.. .... .| |||||.||..|..|..
vtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlv

LAYLMKvRQIRLEEAFEFVRSERT-VISPNLAFMLQLL
..|||. ... ||||.|..|. |. |. ||  |..||.
alylml.lgvsleealeeyrlkrpgvvqpnqqflfqlf
subfamily_MKPLT_pd Subfamily MKPLT 181-312 5.1e-30 98.2 In-house 26-158 (164) alignment 
Range on Protein: 181-312
Range on HMM: 26-158/164.0
LPHLYLGSNFHASRLAVLEEHGITAVLNVSR-LPNYFPTCFRYMQILVDDNTDADLLPWFEEANNFIDSIERCKGRVLVHCHAGISRSATICLAYLMKVR
  .||||   ||    ||..  || ..|||.   . ||  . |.|. |.|..|  | ...| |..|. .     |||||||  | |||... .|.|.| .
edtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiksk

QIRLEEAFEFVRSERTVISPNLAFMLQLLRFEN
.  |.||.|...  |....||  |. || .||.
gwtlkeayeylkerrsivapnrGflkqlakfee
subfamily_MKPLV_pd Subfamily MKPLV 181-312 5.1e-30 98.2 In-house 26-158 (164) alignment 
Range on Protein: 181-312
Range on HMM: 26-158/164.0
LPHLYLGSNFHASRLAVLEEHGITAVLNVSR-LPNYFPTCFRYMQILVDDNTDADLLPWFEEANNFIDSIERCKGRVLVHCHAGISRSATICLAYLMKVR
  .||||   ||    ||..  || ..|||.   . ||  . |.|. |.|..|  | ...| |..|. .     |||||||  | |||... .|.|.| .
edtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiksk

QIRLEEAFEFVRSERTVISPNLAFMLQLLRFEN
.  |.||.|...  |....||  |. || .||.
gwtlkeayeylkerrsivapnrGflkqlakfee
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 183-312 3.1e-28 92.2 In-house 14-145 (148) alignment 
Range on Protein: 183-312
Range on HMM: 14-145/148.0
HLYLGSNFHASRLAVLEEHGITAVLNVSR-LPNYFP-TCFRYMQILVDDNTDADLLPWFEEANNFIDSIERCKGRVLVHCHAGISRSATICLAYLMKVRQ
.|.|||  .|. | .|.. |.|.. | ..  .| .     .|... .||. . ||   ||.. .|..  .   .|||||.. |.|||. . |..|.. ..
fLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkr

IRLEEAFEFVRSERTVISPNLAFMLQLLRFEN
. |.||...|.|.|  . ||| |. ||  .|.
vslkealalvkskrryvdpnlgfLkqLaeleq
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 183-313 1.6e-26 86.5 In-house 9-151 (154) alignment 
Range on Protein: 183-313
Range on HMM: 9-151/154.0
HLYLGSNFHASRLAVLEEHGITAVLNV-SRLPNYFPTC---------FRYMQILVDDNTDADLLPWFEEANNFIDSIE--RCKGRVLVHCHAGISRSATI
.||..|   |     |... |. .|||    .| |.           . |... . |... |..  .. | .|||.      ...||||...|.||||..
flyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaal

CLAYLMKVRQIRLEEAFEFVRSERTVISPNLAFMLQLLRFENE
 ..|||. ..| | .|.|.... | .|.||  |. || .|| |
lisylmdklkislslalellkdsryiikPnqGflkqleifeke
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 183-313 1.4e-22 73.3 In-house 5-140 (145) alignment 
Range on Protein: 183-313
Range on HMM: 5-140/145.0
HLYLGSNFHASRLAVLEEHGITAVLNVSRL-----PNYFPTCFRYMQILVDDNTDADLLPWFEEANNFIDSIERCKGRVLVHCHAGISRSATICLAYLMK
.|| || .||. ...|.| ||. ..|..        .     .  . |  .|    ||   |.|  .|||        |.||| ||.||| |. .|.|||
rlyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmk

VRQIRLEEAFEFVRSERTVISPNLAFMLQLLRFENE
  .. | ||   |||.|    ||. |. .||..| .
ycnmtlseaarqvrsnrllaypnvtflknllnlekq
DSPc Dual specificity phosphatase, catalytic domain 184-312 5.3e-41 134.6 Pfam-A 1-132 (133) alignment 
Range on Protein: 184-312
Range on HMM: 1-132/133.0
LYLGSNFHASrLAVLEEHGITAVLNVS-RLPN---YFPTCFRYMQILVDDNTDADLLPWFEEANNFIDSIERCKGRVLVHCHAGISRSATICLAYLMKVR
|||||. .|| ||.||..|||.|.||. . ||   . .. ..|..| |.|.|.... ...||| .||...|. ...||||| ||||||||...||||| .
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

QIRLEEAFEFVRSERTVISPNLAFMLQLLRFEN
...|.||.|||...|  ||||  |. ||| .|.
nlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 184-312 5.3e-41 134.6 In-house 1-132 (133) alignment 
Range on Protein: 184-312
Range on HMM: 1-132/133.0
LYLGSNFHASrLAVLEEHGITAVLNVS-RLPN---YFPTCFRYMQILVDDNTDADLLPWFEEANNFIDSIERCKGRVLVHCHAGISRSATICLAYLMKVR
|||||. .|| ||.||..|||.|.||. . ||   . .. ..|..| |.|.|.... ...||| .||...|. ...||||| ||||||||...||||| .
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

QIRLEEAFEFVRSERTVISPNLAFMLQLLRFEN
...|.||.|||...|  ||||  |. ||| .|.
nlslneAyefvkerrskispnagflrqLleyer
0045450 (Phosphotyrosine protein) phosphatases II 190-313 3.5e-28 94.7 In-house 87-302 (307) alignment 
Range on Protein: 190-313
Range on HMM: 87-302/307.0
FHASRL--------------------------------AVLEEHGITAVLNVSRLP--------NYFPTC---------------------FRYMQILVD
..||                                    | |.|.|.......|          |.|.                      . .... | 
iNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevt

DN-----------------TDADLLPWFEEANNFIDSIER------CKGRVLVHCHAGISRSATICLAYLMKVRQ--------IRLEEAFEFVRSERTVI
|.                  | .. |.|||. .||. ...      ..|.|||||.||..|..|...||||...         . |.||....|. |  .
dldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpga

SPNLAFMLQLLRFENE
 .|. .. .| ... |
vqnpeqyrflyealle
0040438 (Phosphotyrosine protein) phosphatases II 197-313 1.7e-24 82.1 In-house 105-274 (317) alignment 
Range on Protein: 197-313
Range on HMM: 105-274/317.0
VLEEHGITAVLNVSRLPNY----------------------------FPTCFRYMQILVDDN----------------TDADLLPWFEEANNFIDSIERC
 . |.|.| .... .|  .                                . . .. | |.                .| .. |....  .|.. ....
mvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrea

----KGRVLVHCHAGISRSATICLAYLM-----KVRQIRLEEAFEFVRSERTVISPNLAFMLQLLRFENE
    .| |||||.||..|..|...||||     | ... .|||....|. |  . ...... .| ....|
ledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalle
0039614 (Phosphotyrosine protein) phosphatases II 197-313 6.5e-22 73.8 In-house 120-287 (297) alignment 
Range on Protein: 197-313
Range on HMM: 120-287/297.0
VLEEHGITAVLNVSRLPNYFPTCFRYM----------------------------------------QILVDDNTDADLLPWFEEANNFIDSIER-----
 . |.|.|..... .|  .  .|..|                                         .... .  | .  | .|   .|.. ...     
mvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealael

-CKGRVLVHCHAGISRSATICLAYLM-----KVRQIRLEEAFEFVRSERTVISPNLAFMLQLLRFENE
  .|.|||||.||..|..|...||||     | ... ..||....|. |  . ... .. .| ... |
pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydalle
0043336 (Phosphotyrosine protein) phosphatases II 198-312 7.5e-21 70.3 In-house 108-274 (278) alignment 
Range on Protein: 198-312
Range on HMM: 108-274/278.0
LEEHGITAVLNVSRLP------------------------------------------------NYFPTCFRYMQILvDDNTDADLLPWFEEANNFIDSI
. |.|.| .... .|                                                  .. | . |. .  |...  .| . ..  . ... .
vwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp.dhgvpeslsllldflkavreal

ERCKGRVLVHCHAGISRSATICLAYLM-----KVRQIRLEEAFEFVRSERTVISPNLAFMLQLLRFEN
| ..| |||||.||..|..|....||.     | . . ||||....|. |  . ... .. .| ... 
edsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall
subfamily_PTPMT1_pd Subfamily PTPMT1 199-312 4.6e-17 57.0 In-house 55-166 (171) alignment 
Range on Protein: 199-312
Range on HMM: 55-166/171.0
EEHGITAVLNVSRlpNYFPTCFRYMQILVDDNTDADLLPWFEEANNFIDSIERCKGRVLVHCHAGISRSATICLAYLMKVRQIRLEEAFEFVRSERTVIS
||. ..|. | ..  ..  .   ..|. . | |.|  |   |.. .||...   . || |||.|| .||||.  .|||| ... .||| ..... |  | 
eeyelkalanste..ewkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiir

PNLAFMLQLLRFEN
 . . . .| ..|.
lakkqwkalqeyee
0038934 (Phosphotyrosine protein) phosphatases II 201-313 7.5e-21 70.1 In-house 55-175 (194) alignment 
Range on Protein: 201-313
Range on HMM: 55-175/194.0
HGITAVLNVSR-LPNYFPTCFRYMQILVDDNTDAD--LLPWFEEANNFIDSI-----ERCKGRVLVHCHAGISRSATICLAYLMKVRQIRLEEAFEFVRS
.....|....   . | |. |  . | . .    |    | .|  ..|.| .     |  .| |.|||.||..|..|.. |||...... .||| ...|.
vklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfre

ERTVISPNLAFMLQLLRFENE
 |  . ||  .. .||.. .|
kRpgaipnqdyleallkryke
0051299 (Phosphotyrosine protein) phosphatases II 203-303 1.1e-15 53.3 In-house 163-274 (288) alignment 
Range on Protein: 203-303
Range on HMM: 163-274/288.0
ITAVLNVSRL--PNYFPTCFRYMQILVDDNTDADLLPWFEEANNFIDSIERC----KGRVLVHCHAGISRSATICLAYLM-----KVRQIRLEEAFEFVR
.. .| |..|  ...  ........ . .  | .  . .|.  .|.  . ..    .| |.|||.||..|..|.....|.     | . . ..||....|
tvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlr

SERTVISPNLAF
. |  . ...  
eqRpgmvqtpeq
0047943 (Phosphotyrosine protein) phosphatases II 213-309 1.7e-17 59.2 In-house 159-266 (273) alignment 
Range on Protein: 213-309
Range on HMM: 159-266/273.0
PNYFPTCFRYMQILVDDNTDADLLPWFEEANNFIDSIER------CKGRVLVHCHAGISRSATICLAYLM-----KVRQIRLEEAFEFVRSERTVISPNL
.. .. .. ...... .  | .  | .|.  .||. ...       .| |.|||.||..|..|.....|.     | ... ..||. ..|| |  . ...
nlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtp

AFMLQLLR
 ....| .
eqyrflye
0050432 (Phosphotyrosine protein) phosphatases II 213-301 3.4e-14 48.3 In-house 151-285 (308) alignment 
Range on Protein: 213-301
Range on HMM: 151-285/308.0
PNYFPTC---------------------------------------FRYMQILVDDNTDADLLPWFEEANNFIDSIERC--KGRVLVHCHAGISRSATIC
. |.|.                                        ......   .  | .  | .|.  .|.. ....  .| ..|||.||..|..|..
aqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfi

LAYLM-----KVRQIRLEEAFEFVRSERTVISPNL
...|.     | . . ..||. ..|. |    ...
aldllleqlekeggvdvfeavkklReqRpgmvqtp
0046845 (Phosphotyrosine protein) phosphatases II 216-301 1.8e-13 45.9 In-house 161-260 (284) alignment 
Range on Protein: 216-301
Range on HMM: 161-260/284.0
FPTCFRYMQILVDDNTDADLLPWFEEANNFIDSIERC------KGRVLVHCHAGISRSATICLAYLMKVR--------QIRLEEAFEFVRSERTVISPNL
    .. ... . .  | .  | .|   .|.. ....      .| ..|||.||..|..|.....|.. .         . ..||. ..|. |     .|
tgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtl
0048567 (Phosphotyrosine protein) phosphatases II 231-294 2e-10 35.3 In-house 52-118 (157) alignment 
Range on Protein: 231-294
Range on HMM: 52-118/157.0
TDADLLPWFEEANNFIDSIERCKGRVLVHCHAGI---SRSATICLAYLMKVRQIRLEEAFEFVRSER
. | |  ..  .|.|....| ..... |||.||    .|.||.. .||... ..  |||....|  |
nlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivr
PTPc_DSPc_SM00012 235-281 1.2e-08 30.4 In-house 22-67 (105) alignment 
Range on Protein: 235-281
Range on HMM: 22-67/105.0
LLPWFEEANNFIDSIERcKGRVLVHCHAGISRSATICLAYLMKVRQI
.| .... ...   .|. .. |.|||.||..|..|.......  .  
ilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqle
subfamily_PTEN_pd Subfamily PTEN 240-295 2.8e-06 22.4 In-house 103-157 (184) alignment 
Range on Protein: 240-295
Range on HMM: 103-157/184.0
EEANNFIDSIErcKGRVLVHCHAGISRSATICLAYLMKVRQIRLE-EAFEFVRSERT
|........ .  |  | |||.||  |. ..  |||.| .... . || |.  . ||
ediekwleedk..knvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRt
subfamily_CDC14_pd Subfamily CDC14 243-305 2.2e-10 34.9 In-house 253-317 (328) alignment 
Range on Protein: 243-305
Range on HMM: 253-317/328.0
NNFIDSIERCKGRVLVHCHAGISRSATICLAYLMKVRQIRLEEAFEFVRSER--TVISPNLAFML
..|.. .|...| . |||.||. |  |.  .||||  ..  .||  ..|  |  .||.|   |. 
kkfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGsvigpqqkfle
Y_phosphatase Protein-tyrosine phosphatase 244-294 2.1e-06 22.7 Pfam-A 157-216 (235) alignment 
Range on Protein: 244-294
Range on HMM: 157-216/235.0
NFIDSIERCK----GRVLVHCHAGISRSATICLAYLMKVRQ-----IRLEEAFEFVRSER
..|...|. |    | |.||| ||..|..|.... ..  .      . . .. . .|..|
dlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqR
Y_phosphatase Protein-tyrosine phosphatase 244-294 2.1e-06 22.7 In-house 157-216 (235) alignment 
Range on Protein: 244-294
Range on HMM: 157-216/235.0
NFIDSIERCK----GRVLVHCHAGISRSATICLAYLMKVRQ-----IRLEEAFEFVRSER
..|...|. |    | |.||| ||..|..|.... ..  .      . . .. . .|..|
dlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqR
subfamily_RNGTT_pd Subfamily RNGTT 244-294 2.9e-06 21.1 In-house 106-154 (189) alignment 
Range on Protein: 244-294
Range on HMM: 106-154/189.0
NFIDsiERCKGRVLVHCHAGISRSATICLAYLMKVRQIRLEEAFEFVRSER
.|..  .. .  . |||. |  |.  .  .||...... .|.| .  .. |
effk..knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaR
subfamily_MSG5_pd Subfamily MSG5 246-312 1.2e-14 47.7 In-house 92-158 (165) alignment 
Range on Protein: 246-312
Range on HMM: 92-158/165.0
IDSIERCKGRVLVHCHAGISRSATICLAYLMKVRQIRLEEAFEFVRSERTVISPNLAFMLQLLRFEN
| . .  . ..||||  |.||||.. .||.||  .. |..|.. ..|    |||.. ...||. .| 
ihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewev
DSPc_SM00195 246-276 4.1e-06 21.7 In-house 194-218 (263) alignment 
Range on Protein: 246-276
Range on HMM: 194-218/263.0
IdsiercKGRVLVHCHAGISRSATICLAYLM
.      .| ..|||.||..|..|.... ..
s......sgpivVhCsaGvgRtgtfvtidii
PTPc_SM00194 246-276 4.1e-06 21.7 In-house 194-218 (263) alignment 
Range on Protein: 246-276
Range on HMM: 194-218/263.0
IdsiercKGRVLVHCHAGISRSATICLAYLM
.      .| ..|||.||..|..|.... ..
s......sgpivVhCsaGvgRtgtfvtidii
subfamily_PTPDC1_pd Subfamily PTPDC1 253-295 2.2e-08 28.8 In-house 114-156 (182) alignment 
Range on Protein: 253-295
Range on HMM: 114-156/182.0
KGRVLVHCHAGISRSATICLAYLMKVRQIRLEEAFEFVRSERT
.|.| ||||||  |   .  .||. ....  |.| ..|||.|.
egkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrp