Gene PTPDC1 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily PTPDC1
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP023_AA protein Get Run
SpurP023_AA_70-231 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0045450 (Phosphotyrosine protein) phosphatases II 54-232 2.7e-26 88.5 In-house 19-304 (307) alignment 
Range on Protein: 54-232
Range on HMM: 19-304/307.0
KYDNPSKWSEDQMAIKGLFSHW---LIAMNLISWVIDKTKQRYAA-------------------------------------------------------
... .. ..  . ... |.| .   |. ..  ...  |.| ||                                                         
llllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe

------KELILHGIKAVINLQTKGEHAH----CGLGLEpGGF-SYDQ-------------------------EEFMENDIFFYNF-GWDDYGVK-SLTFI
      . |  .|......| .  |...        .| |..  |..                         .....  .  . . || |.||  |.  .
tvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeel

LDMVKVMTFAV----KEGKVGVHCHAGLGRTGVLIACYLIYAKR--------FDGDHAIHFVREKRPGSIQTKGQVECCQQFAQFLI
||... .  |.    |.|.| |||.||.||||..||.||..  .        .| ..|....||.|||..|. .| . .......|.
ldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_PTPDC1_pd Subfamily PTPDC1 60-238 2.4e-86 282.8 In-house 2-182 (182) alignment 
Range on Protein: 60-238
Range on HMM: 2-182/182.0
KWSEDQMAIKGLFSHWLIA--MNLISWVIDKTKQRYAAKELILHGIKAVINLQTKGEHAHCGLGLEPGGFSYDQEEFMENDIFFYNFGWDDYGVKSLTFI
.|||...|||||.|.|...  ..|............ ..... .|||||||||.|||||.|| |||..|||||.|..||..|..|||||.||||.||. |
rwseeeqaikGlystWvtedilalarpsqeaideyklldkfkesgikavinLqekgehasCGagleesGfsYdlealmeqgiyvynfgwkDygvasleri

LDMVKVMTFAVKEGKVGVHCHAGLGRTGVLIACYLIYAKRFDGDHAIHFVREKRPGSIQTKGQVECCQQFAQFLIPLRVVF
||.|||..||..||||.||||||||||||||||||.||||.....||..||.||| ||||..|||....||.||||||.|.
LdivkvvafalqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvkefalfliplrkvy
0039614 (Phosphotyrosine protein) phosphatases II 81-232 1.7e-26 88.9 In-house 50-289 (297) alignment 
Range on Protein: 81-232
Range on HMM: 50-289/297.0
LISWVIDKTKQRYA------------------------------------------------------AKELILHGIKAVINLQTKGEHAHCGL------
   ..  |.| ||                                                        . .  .|......| .  |. ..        
iallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpee

-GlEPGGFS-YDQEEFMENDIFFYNF-----------------GWDDYGVK-SLTFILDMVKVMTFAV----KEGKVGVHCHAGLGRTGVLIACYLI---
 | . |.|. .  ......... ...                 || |.||  ||. .|.... .  |.    |.|.| |||.||.||||..||.||.   
gg.tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleq

--YAKRFDGDHAIHFVREKRPGSIQTKGQVECCQQFAQFLI
  . ...| ..|....||.|||..|| .| . .......|.
lekeggvdvleavkelreqRpgavqtpsqyrflydallell
0043336 (Phosphotyrosine protein) phosphatases II 87-231 3e-24 81.4 In-house 45-276 (278) alignment 
Range on Protein: 87-231
Range on HMM: 45-276/278.0
DKTKQRYA----------------------------------------------------AKELILHGIKAVINLQTKGEHAHCG---------------
 |.| ||                                                      . .  .|.. ...| .  |. ...               
nkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdf

-----------------LGLEPggfSYDQEEFMENDIFFynFGWDDYGVK-SLTFILDMVKVMTFAV--KEGKVGVHCHAGLGRTGVLIACYLI-----Y
                 | ...    .| |... . . .  .|| |.||  ||. .||..|..  |.  ..|.| |||.||.||||..||.||.     .
tvtllkeehlddytvrtlevtn...lgdgesrtvthyhy..lgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlek

AKRFDGDHAIHFVREKRPGSIQTKGQVECCQQFAQFL
 ...| ..|....||.|||..||  | . . ......
eggvdleeavkelreqRpgavqtpsqyrflyealley
0040439 (Phosphotyrosine protein) phosphatases II 90-232 2e-25 85.3 In-house 14-246 (249) alignment 
Range on Protein: 90-232
Range on HMM: 14-246/249.0
KQRYA----------------------------------------------------AKELILHGIKAVINLQTKGEH--AHCGLGLEPGGFS-------
| ||                                                      . |  .||.....| .  |.   .|     .||.        
knrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftv

---------------------YDQEEFMENDIFFYNFGwdDYGVK-SLTFILDMVKVMTFAV----KEGKVGVHCHAGLGRTGVLIACYLI-----YAKR
                     ||.|... . | ....   |.||  |.  .||... .  |.    |.|.| |||.||.||||..||.||.     . ..
tllsvevkddytvrtleltnlydgesrtvlhiqytdwp..dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelg

FDGDHAIHFVREKRPGSIQTKGQVECCQQFAQFLI
.| ..|....|..|||..|. .| . .......|.
vdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Laforin_pd Subfamily Laforin 90-222 6.6e-06 19.1 In-house 25-163 (183) alignment 
Range on Protein: 90-222
Range on HMM: 25-163/183.0
KQRYAAKELILHGIKAVINLQTKGEHAHCGLGL--EPGGFSYD-QEEFMENDIFFYNFGWDDYGVKSLTFILDM-VKVMTFAVKEG-KVGVHCHAGLGRT
...    .|  .|| |||.|||. .  .   |.   .  .    .  . |. . .  .  .|   .|    |   | ..   ...| .| ||| ||.||.
rlvehvidlksegitavislqtesdivknssgiyrynenlpitlkklykeeglayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrs

GVLIACYLIYAKRFDGDHAIHFVREKRPGS-IQTKGQVE
  ..  .| |   ..  .  .|.  |||   |. .  . 
taivcgflqyvlgwslakvqyfllakrpvvyideealir
DSPc Dual specificity phosphatase, catalytic domain 95-217 3.1e-15 51.2 Pfam-A 11-120 (133) alignment 
Range on Protein: 95-217
Range on HMM: 11-120/133.0
AKELILHGIKAVINLQTKGEHAhcglglepggFSYDQEEFMENDIFfYNFGWDDYGVKSLTFILDMVKvmTFAVKEGKVGVHCHAGLGRTGVLIACYLIY
 . |  .||..|||.... ...          ... ..|. . .|   .  ...  .| |  . ....  ... |..|| ||| ||. |.. ||..||..
lalleklgitlvinvtkevpnn..........naikkseieylrip.vedetetkiskeleeavefie..kaeqkgkkvlVHCqaGisRSatliiaYlmk

AKRFDGDHAIHFVREKRPGSIQT
 |... ..|..||.|.|.   ..
tknlslneAyefvkerrskispn
DSPc Dual specificity phosphatase, catalytic domain 95-217 3.1e-15 51.2 In-house 11-120 (133) alignment 
Range on Protein: 95-217
Range on HMM: 11-120/133.0
AKELILHGIKAVINLQTKGEHAhcglglepggFSYDQEEFMENDIFfYNFGWDDYGVKSLTFILDMVKvmTFAVKEGKVGVHCHAGLGRTGVLIACYLIY
 . |  .||..|||.... ...          ... ..|. . .|   .  ...  .| |  . ....  ... |..|| ||| ||. |.. ||..||..
lalleklgitlvinvtkevpnn..........naikkseieylrip.vedetetkiskeleeavefie..kaeqkgkkvlVHCqaGisRSatliiaYlmk

AKRFDGDHAIHFVREKRPGSIQT
 |... ..|..||.|.|.   ..
tknlslneAyefvkerrskispn
subfamily_CDKN3_pd Subfamily CDKN3 96-228 7e-09 29.5 In-house 64-192 (202) alignment 
Range on Protein: 96-228
Range on HMM: 64-192/202.0
KELILHGIKAVINLQTKGEHAHCGLglepggfSYDQEEFMENDIFFYNFGWDDYGVKSLTFILDMVKVMTFAVKEGK-VGVHCHAGLGRTGVLIACYLIY
.||.  |.. |. | |.|| ..  .           ... .  .  . .   | .| . .  |.... .. ..|...   |||. ||||. ..||| |.|
eelksqgvedvfvlctrgelskyrv.......rrlldlyqqaglivhhypiadglvpdiasclkileelrinlkayrktlvhcygglgrsslviacllly

AK-RFDGDHAIHFVREKR-PGSIQTKGQVECCQQFA
 .  .. ..||  .|. .  ..|||  | .  ..| 
lddtiepkdaidklrdlkgsraiqtvkqynylsefr
0046846 (Phosphotyrosine protein) phosphatases II 97-231 1.1e-32 108.6 In-house 42-172 (176) alignment 
Range on Protein: 97-231
Range on HMM: 42-172/176.0
ELILHGIKAVINLQTKGEHAHCGlglepggFSYDQEEFMENDIFFYNFGWDDYGVKSLTFILDMVKVMTFAVKEG-KVGVHCHAGLGRTGVLIACYLIYA
.|  .||.||.||..  |.....       . .. .|.....| .....|.|.|| .|. .|.... .  |.||| .| |||.||.||||.|.|.||.. 
mlkelgitavvnlteevelgrlk.......cpnywpeleklgiqylhlpwpDhgvpdlelllellefirealkeggpvlVHCsaGigRtgtlvaayllel

-KRFDGDHAIHFVREKRP-GSIQTKGQVECCQQFAQFL
 | .. ..|...|||.|| |..|| .|.. ...|...|
ekglsveealalvreqRplgavqtpeQyrflyefelll
0044763 (Phosphotyrosine protein) phosphatases II 97-234 4.8e-29 96.7 In-house 43-173 (178) alignment 
Range on Protein: 97-234
Range on HMM: 43-173/178.0
ELILHGIKAVINLQTKGEHAHCGlglepggfsYDQEEFMENDIFFYNFGWDDYGVKS-LTFILDMVKVMTFA--VKEGKVGVHCHAGLGRTGVLIACYLI
 |  .||....|| .  |. ...         .|.. ..|..| .......|.|| . | ..|..|. .  |   |.|.| |||.||.||.|.|.|.||.
llkelgithivnlteelelgflk.........cdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylm

YAKRFDGDHAIHFVREKRPgSIQTKGQVECCQQFAQFLIPL
.  ... ..||..|||.||  ... ||.. ...|...| . 
kklglsleeaielvrerRp.ivpnpgqlrqLyefelrllke
0048076 (Phosphotyrosine protein) phosphatases II 97-231 2.5e-28 93.9 In-house 24-142 (145) alignment 
Range on Protein: 97-231
Range on HMM: 24-142/145.0
ELILHGIKAVINLqtkgehahcglglepggfSYDQEEFMENDIFFYNFGWDDYGVKSL-TFILDMVKVMTFAVKEG-KVGVHCHAGLGRTGVLIACYLIY
.|  .||..|.||                  ....| . ...| .....|.|.|| .|  ..|.... .  |.||| .| |||.||.||||.|.|.||..
llkdlgittvlnl..................tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylml

AKRFDGDHAIHFVREKRPGSIQTKGQVECCQQFAQFL
 .... ..|...||..|||.... ||.. ...| . |
llgvsleealelvrsqrpgavpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 97-230 6.2e-27 89.5 In-house 24-143 (144) alignment 
Range on Protein: 97-230
Range on HMM: 24-143/144.0
ELILHGIKAVINLQTKGEHAHCGLGlepggfsydqeefmenDIFFYNFGWDDYGVKSL-TFILDMVKVMTFAVK-EGKVGVHCHAGLGRTGVLIACYLIY
.|  .||..||||... |.....                   | .....|.|.|| .| ...|.... .  |.. .|.| |||.||.||||.|.|.||..
llkklgittvinlteeyepeflere................giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk

AKRFDGDHAIHFVREKRPGSIQTKGQVECCQQFAQF
 .... ..|...||..|||.... ||.. .... ..
klglsleealalvrsrrpgavpnpgqlrfLleyekl
PTPc_motif_SM00404 97-217 1.9e-14 48.8 In-house 22-126 (140) alignment 
Range on Protein: 97-217
Range on HMM: 22-126/140.0
ELILHGIKAVINLQTKGEHAhcglglepggfsydqEEFMENDIFFYNfGWDDYGVKSLTFILDMVKVM-TFAVKEGKVGVHCHAGLGRTGVLIACYLIYA
 |  .||..|||.... .                 .|  .  |. ..   |.   | . ..  ..... ... |.||| ||| ||. |.. ||..||.. 
llkklgithvinvteevslt...............kensgfqilqip.lddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlmry

KRFDGDHAIHFVREKRpGSIQT
. .. ..|..||.|.|  .|. 
rqlslaeayefvkerR.piisp
0045098 (Phosphotyrosine protein) phosphatases II 98-232 1.1e-26 89.3 In-house 84-272 (278) alignment 
Range on Protein: 98-232
Range on HMM: 84-272/278.0
LILHGIKAVINLQTKGEHA--HCGLGLEPGG-----------------------------FSYDQEEFMENDIFFYNF-GWDDYGVKSLT---FILDMVK
|  .||.....| .  | .  .|     .||                             ... .|..... .. ... .|.|.|| ||.   ..|....
lwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflelle

VMTFAV---------------KEGKVGVHCHAGLGRTGVLIACYLIYAK---RFDGDHAIHFVREKRPG-SIQTKGQVECCQQFAQFLI
 .  |.               ..|.| |||.||.||||.|.|.||..     ..| ..|....|..||| ..|...| . . .|.. |.
firealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllell
0051082 (Phosphotyrosine protein) phosphatases II 98-224 8.3e-22 72.8 In-house 29-145 (151) alignment 
Range on Protein: 98-224
Range on HMM: 29-145/151.0
LILHGIKAVINLQTKGEHAhcglglepggfsYDQEEFMENDIFFYNFGWDDYGVKSL----TFILDMVKVMTFaVKEGKVGVHCHAGLGRTGVLIACYLI
|  .|||...|| .. |..            |. | . |..| .... ..|  . .|     ..|......    |.|.| |||.||.||||.|.|.||.
lkelgiktivnlrseeerg............ycpeylpelgievlhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkgRTGtlvalylm

YaKRFDGDHAIHFVREKRPGSIQTKGQVECC
.  ... . |....|.||||..|.. |  ..
l.lgvsleealeeyrlkrpgvvqpnqqflfq
0043147 (Phosphotyrosine protein) phosphatases II 99-232 3e-31 103.8 In-house 41-161 (172) alignment 
Range on Protein: 99-232
Range on HMM: 41-161/172.0
ILHGIKAVINLQTKgehahcglglepggfSYDQEEFMENDIFFYNFGWDDYGVKSLTFILDMVKVMTF---AVKEGKVGVHCHAGLGRTGVLIACYLIYa
  .||....|| .                 || | .....| .. ..|.|.|| .| ..|.... .       ..|.| |||.||.||||.|.|.||.. 
kelgithivnltel...............lydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.

KRFDGDHAIHFVREKRPGSIQTKGQVECCQQFAQFLI
.... ..|...|||||||..|...|  ....|...|.
lglsleeavalvrekRpgavqnpsqyrflyyfeklll
0041856 (Phosphotyrosine protein) phosphatases II 99-233 2e-29 97.9 In-house 55-172 (182) alignment 
Range on Protein: 99-233
Range on HMM: 55-172/182.0
ILHGIKAVINLQtkgehahcglglepgGFSYDQEEFMENDIFFYNFGWDDYGVKSLTFILDMVKVMTFavKEGKVGVHCHAGLGRTGVLIACYLIYAKRF
  .||....||                .. |. |... . | .....|.|.|| .|  .||... .    ..|.| |||.||.||||.|.|.||.. ...
kelgittivnlt...............eelywpellerlgiqylylpwpDhgvpdldelldfieevle..eggpvlVHCsaGvgRtgtlvaaylmkklgv

DGDHAIHFVREKRPGSIQTKGQVECCQQFAQFLIP
. ..|...||..|||...|  |   .|... .|. 
sleeavklvrsrRpgmvitpnqyfflqlallelll
0036282 (Phosphotyrosine protein) phosphatases II 99-229 7.8e-28 92.7 In-house 33-167 (174) alignment 
Range on Protein: 99-229
Range on HMM: 33-167/174.0
ILHGIKAVINLQTKGEHAHCGLGLEPGGfsyDQEEFMENDIFFYNFGWDDYGVKSLTFILDMVKVMTFAVKE---GKVGVHCHAGLGRTGVLIACYLIYA
  .||..|..| .  |  ...          ..| . ...| .. ..|.|.|| .|. .|..|| .  |..|   |.| |||.||.||||.|.|.||.. 
kelgittvvmlleekelglykcinywpe...lredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlr

KRF-DGDHAIHFVREKR---PGSIQTKGQVECCQQFAQ
  . . ..|...|||.|   ||..|| .| . ...| .
glleslvdaldlvrelRlqrpgmvqtpsQyrflyyfek
0038934 (Phosphotyrosine protein) phosphatases II 100-232 1.5e-31 104.9 In-house 40-177 (194) alignment 
Range on Protein: 100-232
Range on HMM: 40-177/194.0
LHGIKAVINL-QTKGEHAHCGLGLEPGGFSYDQEEFMENDIFFYNFGWDDYGV----KSLTFILDMVKVMTFAVKEGKVGVHCHAGLGRTGVLIACYLIY
 .... .... ...... .. . |   .. || |||....| .... . |.|.    . |. .||.|.... . ..|.|.|||.|||||||.|.|.||||
rfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiy

AKRFDGDHAIHFVREKRPGSIQTKGQVECCQQFAQFLI
  ... . ||...||||||.|.. ...|  ... ..|.
rlgmsaeeAialfrekRpgaipnqdyleallkrykelr
0042113 (Phosphotyrosine protein) phosphatases II 100-231 3.4e-26 87.6 In-house 74-242 (245) alignment 
Range on Protein: 100-231
Range on HMM: 74-242/245.0
LHGIKAVINLQTKGEHAHCG--LG------LEPGGFS--------------------YDQEEFMENDIFFYNFGWDDYGVKS-LTFILDMVKVMTFAVK-
 .||.....| .  |. ...          |. |.|.                    .... .  ..| .. ..|.|.|| . |  .||... .  |.. 
elgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae

--EGKVGVHCHAGLGRTGVLIACYLI-----YAKRFDGDHAIHFVREKRPGSIQTKGQVECCQQFAQFL
  .|.| |||.||.||||..||.||.     . .... ..|....|..|||..|| .| . .......|
dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
0049260 (Phosphotyrosine protein) phosphatases II 101-230 4.8e-28 93.2 In-house 32-148 (152) alignment 
Range on Protein: 101-230
Range on HMM: 32-148/152.0
HGIKAVINLQTKGEHAHCGLGLEPggfsydqeefmendiFFYNFGWDDYGVKSLTFILDMVKVMT---FAVKEGKVGVHCHAGLGRTGVLIACYLIYaKR
.||.....| .  | ....    .                .... |.|.|| .|...|...  .       |.|.| |||.||.||||.|.|.||.. ..
lgittivmltellelgklkceqyi...............qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.lg

FDGDHAIHFVREKRPGSIQTKGQVECCQQFAQF
.. ..|. .|||||||.....|| . ...|...
vsleeavalvrekRpgavpnpgqlrflyefekl
0037934 (Phosphotyrosine protein) phosphatases II 101-231 4.5e-25 84.1 In-house 71-241 (243) alignment 
Range on Protein: 101-231
Range on HMM: 71-241/243.0
HGIKAVINLQTKGEHAHCGLGLEP-GGF--------------------------SYDQEEFMENDIFFYNFGWDDYGVKS-LTFILDMVKVMT-------
.||.....| .  |. ...      |..                           .| ...  ..| .. ..| |.|| .  . .||... ..       
lgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieell

---FAVKEGKVGVHCHAGLGRTGVLIACYLIYAK-RFDGDHAIHFVREKRPG-SIQTKGQVECCQQFAQFL
    . ..|.| |||.||.||||.|||.||.. . ..| ..|....||.||| ..|| .| . .......|
sllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeallel
0051429 (Phosphotyrosine protein) phosphatases II 101-231 9.7e-23 76.6 In-house 44-224 (272) alignment 
Range on Protein: 101-231
Range on HMM: 44-224/272.0
HGIKAVINLQTKGEHAHCGLGLEPGGFSYDQEEFMENDIFFYNFG-----------------------------------------WDDYGV--KSLTFI
.|||....| .  |.....  ... |. | .  ..... .....|                                         | |.||  ..|  .
lgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallel

LDMVKVmtfavkEGKVGVHCHAGLGRTGVLIACYLIYaKRFD--------------GDHAIHFVREKRPGSIQTKGQVECCQQFAQFL
|...        .|.| |||.|| .|||...|..|..  ...               ..|.. .|..|||..|| .|......... |
lellld......ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallel
subfamily_CDC14_pd Subfamily CDC14 101-221 7.5e-19 62.7 In-house 211-314 (328) alignment 
Range on Protein: 101-221
Range on HMM: 211-314/328.0
HGIKAVINLQTKgehahcglglepggfSYDQEEFMENDIFFYNFGWDDYGVKSLTFILDMVKVMTFAvkEGKVGVHCHAGLGRTGVLIACYLIYAKRFDG
.....|. |  |                ||...| .. .  ..  . | .. | . .  .....  |  ||.. |||.||||||| ||||||..  ||  
nnvttvvrLnkk...............lYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka..eGaiavhCkaGLGrtGtLiacylmkhyrfta

DHAIHFVREKRPGSIQTKGQV
  || ..|  ||||. .. | 
aeaiawlricrPGsvigpqqk
PTEN_1 104-231 5.4e-36 119.3 In-house 58-192 (196) alignment 
Range on Protein: 104-231
Range on HMM: 58-192/196.0
KAVINLQTKGEHAHCGLGLEP--GGFSYDQEEFMENDIFFYNFGWDDYGVKSLTFILDMVKVMTFAVK----EGKVGVHCHAGLGRTGVLIACYLIYAKR
. . ||. .| .... | .|.  .|.||| |||..... ...|...|.|. || ...|..|..  ...    ...| |||.|||||.|...|.||.|...
adldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk

FDGDHAIHFVREKR-PGSIQTKGQVECCQQFAQFL
.. | |. .||||| ||....  | .. ..||..|
ltadeAlelvrekRppgapnspsqerlleyfaell
0049772 (Phosphotyrosine protein) phosphatases II 113-228 8.8e-23 76.9 In-house 167-276 (314) alignment 
Range on Protein: 113-228
Range on HMM: 167-276/314.0
GehahcglglepgGFSYDQEEFMENDIFFYNFGWDDYGVKSLTFILDMVKVMTFAVKEGKVGVHCHAGLGRTGV-LIACYLIYAKRFDGDHAIHFVREKR
             .  ||.| | .. | .... ..|... .| .........  | |.|.| |||.|| ||||. ..|.||... ... . |...||.||
k............eelydpelferlgikylripvpDgsaplledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkR

P-----GSIQTKGQVECCQQFA
|     |.|..  | | . .. 
pinpnpgfieqleqyefileal
subfamily_PTEN_pd Subfamily PTEN 124-211 1.4e-10 36.5 In-house 71-156 (184) alignment 
Range on Protein: 124-211
Range on HMM: 71-156/184.0
PggfSYDQEEFmENDIFFYnfGWDDYGVKSLTFILDMVKVMTFAVKEGK---VGVHCHAGLGRTGVLIACYLIYAKRFDGD-HAIHFVREKR
    .||...| .. .  |  . ||    .| .. ..|. ..  ..| |   | |||.|| |||||||..||.... ..   .|...  |.|
r...kydskkf.dgrvavy..pfdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaR
0048567 (Phosphotyrosine protein) phosphatases II 127-225 4e-15 50.5 In-house 26-132 (157) alignment 
Range on Protein: 127-225
Range on HMM: 26-132/157.0
FSYDQEEFMENDIFFYNFGWDDYGVKSLTFILDMVKVMTF-----AVKEGKVGVHCHAGL---GRTGVLIACYLIYAKRFDGDHAIHFVREKRPGSIQTK
  |.   |  .| ..|.  . |.|  .|... . ....         ..... |||.|||   |||..||.||||.  .|. . ||...|  ||||.   
slynalyFsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfr

GQVECCQ
 .     
dasylls
subfamily_PRL_pd Subfamily PRL 128-221 4.5e-13 43.5 In-house 45-139 (151) alignment 
Range on Protein: 128-221
Range on HMM: 45-139/151.0
SYDQEEFMENDIFFYNFGWDDYGVKSLTFILDMVKVMTFAVK---EGKVGVHCHAGLGRTGVLIACYLIYAkRFDGDHAIHFVREKRPGSIQTKgQV
.||.|.. ...|   .. .|| .| .   . . ....  . |   .  |.||| |||||. ||.|  || |  .. ..|..|.|||| |.| .| |.
tydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalaliea.Gmkyedavefirekrrgainsk.ql
subfamily_VSP_pd Subfamily VSP 129-212 3.3e-06 21.2 In-house 87-171 (212) alignment 
Range on Protein: 129-212
Range on HMM: 87-171/212.0
YDQEEFmENDIffYNFGWDDYGVKSLTFILDMVKVMT-FAVK--EGKVGVHCHAGLGRTGVLIACYLIYAKRFD-GDHAIHFVREKRP
||.. | .| .   .   ||. | .|  .| . | .  .  |  .  . .||  | |||| .. ..|.... |.  ......  |.| 
ydekyf.nnrv..kriliddhnvpkleellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrt
subfamily_PTPMT1_pd Subfamily PTPMT1 131-231 3.7e-14 47.5 In-house 66-168 (171) alignment 
Range on Protein: 131-231
Range on HMM: 66-168/171.0
QEEFMENDIFFYNFGWDDYG-VKSLTFILDMVKVMTFAV-KEGKVGVHCHAGLGRTGVLIACYLIYAKRFDGDHAIHFVREKRPGSIQTKGQVECCQQFA
.||. .... ....   |.    .|  ... |....    |  .| |||.|| ||.. |.||||.. .... ..|......||.     | |..  |.. 
teewkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeye

QFL
..|
ekl
subfamily_DSP3_pd Subfamily DSP3 133-212 3.6e-08 27.2 In-house 57-139 (162) alignment 
Range on Protein: 133-212
Range on HMM: 57-139/162.0
EFMENDIFFYNFGWDDYGVKSLT-FILDMVKVMTFAVK--EGKVGVHCHAGLGRTGVLIACYLIYAKRFDGDHAIHFVREKRP
 . . .| .. .  ||     |  .    .| .  |..  |||| |||..|. |  .|.  ||.  ....  .||. ||.|| 
fykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkRe
subfamily_PTPN6_pd Subfamily PTPN6 135-222 2e-07 25.3 In-house 184-287 (306) alignment 
Range on Protein: 135-222
Range on HMM: 184-287/306.0
MENDIFFYNF-GWDDYGVKSLTF-ILDMVKVMTF---A---VKEGKVGVHCHAGLGRTGVLIACYLIY----AK----RFDGDHAIHFVREKRPGSIQTK
 | ..| |.|  | | ||.. .  .||... ..         ..| . ||| ||.|||| .|   ..      |     .|  .... ||| | | .||.
eerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqte

GQVE
 |  
qqyk
subfamily_PTPRB_pd Subfamily PTPRB 138-220 2.9e-07 24.8 In-house 180-273 (293) alignment 
Range on Protein: 138-220
Range on HMM: 180-273/293.0
DIFFYNF-GWDDYGVKSLT-FILDMVKVMTFAV----KEGKVGVHCHAGLGRTGVLIACYLIYAKRFDGD-----HAIHFVREKRPGSIQTKGQ
..  |.|  | |.|| . |  .||.|. .  |.    ... . ||| ||.||||..||   .  .  . |       .. .||.|   .||. |
kvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekq
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 138-226 1e-06 23.1 In-house 176-273 (288) alignment 
Range on Protein: 138-226
Range on HMM: 176-273/288.0
DIFFYNF-GWDDYGV-KSLTFILDMVKVMTFAVK--EGKVGVHCHAGLGRTGVLIACYLIY-----AKRFDGDHAIHFVREKRPGSIQTKGQVECCQQ
.|  |.. .| | || .| . .|.... .  | .   |.. ||| ||.||||. ||   .       .  |   ... .|..|.  .||. | | . .
eitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiye
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 138-221 8.1e-06 19.5 In-house 191-277 (302) alignment 
Range on Protein: 138-221
Range on HMM: 191-277/302.0
DIFFYNfGWDDYGVK-SLTFILDMVKVMTfAVKEgKVGVHCHAGLGRTGVLIAC-YLIYA----KRFDGDHAIHFVREKRPGSIQTKGQV
||. .  .| |.|        ||..|    . |. .| ||| ||.|||| |.|  | |      |  |  . .  ||. | |..|.. |.
dilafs.awpdhGapkeaytaldilkfce.sykk.nvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqql
0051299 (Phosphotyrosine protein) phosphatases II 139-230 1.2e-19 66.3 In-house 185-284 (288) alignment 
Range on Protein: 139-230
Range on HMM: 185-284/288.0
IFFYNFGWDDYGVKS-LTFILDMVKVMTFA--VKEGKVGVHCHAGLGRTGVLIACYLI-----YAKRFDGDHAIHFVREKRPGSIQTKGQVECCQQFAQF
. |. ..| |.|| . .. .||... .  |   ..| | |||.||.||||..||..|.     . ...|  .|....||.|||..||  | . . . . .
thfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle
0047943 (Phosphotyrosine protein) phosphatases II 140-229 4e-21 71.1 In-house 170-269 (273) alignment 
Range on Protein: 140-229
Range on HMM: 170-269/273.0
FFYNFGWDDYGVK-SLTFILDMVKVMTF----AVKEGKVGVHCHAGLGRTGVLIACYLI-----YAKRFDGDHAIHFVREKRPGSIQTKGQVECCQQFAQ
 |. .|| |.||  ||. .|......      ....|.| |||.||.||||..||..|.     . ...| . |....|..|||..||  | . . ... 
hfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeall
0046845 (Phosphotyrosine protein) phosphatases II 140-232 6.6e-21 70.4 In-house 169-274 (284) alignment 
Range on Protein: 140-232
Range on HMM: 169-274/284.0
FFYNFGWDDYGVK-SLTFILDMVKVMTFAVK----EGKVGVHCHAGLGRTGVLIACYLIYAK--------RFDGDHAIHFVREKRPGSIQTKGQVECCQQ
 |. ..| |.||  |.. .|.... .  . .    .|.. |||.||.||||..||..|..          ..|  .|....||.|||..||  | . . .
hfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvye

FAQFLI
......
alleyl
subfamily_DSP23_pd Subfamily DSP23 140-230 6e-18 59.9 In-house 53-144 (148) alignment 
Range on Protein: 140-230
Range on HMM: 53-144/148.0
FFYNFGWDDYGVKSLTFILDMVKVMTFAV-KEGKVGVHCHAGLGRTGVLIACYLIYAKRFDGDHAIHFVREKRPGSIQTKGQVECCQQFAQF
 ..... |||   .|  . ..|.|.  |  |.  |.|||  | |||| ..||||.  ...   .||  ||..||||..|  | .  ...  |
tlvrlriddyhppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsvetveqeklvrdyetf
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 140-224 8.9e-07 23.3 In-house 181-275 (319) alignment 
Range on Protein: 140-224
Range on HMM: 181-275/319.0
F-FYNFGWDDYGV-KSLTFILDMVKVMTFAVKE---GKVGVHCHAGLGRTGVLIACYLIYaKRFDGDHA------IHFVREKRPGSIQTKGQVECC
. |.   | | .| ...| .||..| .  ....   | . ||| || ||||  |.   .   |   . .      .  .| .|.  .|.. | . .
khfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldaml.ervkeegvlDvfstvsrlRtqRnimvqrpeqYkfi
0040438 (Phosphotyrosine protein) phosphatases II 141-237 4.2e-24 80.8 In-house 177-281 (317) alignment 
Range on Protein: 141-237
Range on HMM: 177-281/317.0
FYNFGWDDYGVK-SLTFILDMVKVMTFA--VKEGKVGVHCHAGLGRTGVLIACYLI-----YAKRFDGDHAIHFVREKRPGSIQTKGQVECCQQFAQFLI
|.  ||.|.||  |.. .||... .  |   ..|.| |||.||.||||..||.||.     . ...| ..|....||.|||..|| .| . . .......
fhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl

PLRVV
  ...
krklt
0036941 (Phosphotyrosine protein) phosphatases II 141-236 2.7e-21 71.6 In-house 173-281 (297) alignment 
Range on Protein: 141-236
Range on HMM: 173-281/297.0
FYNFGWDDYGVKS-LTFILDMVKVMTFAV----KEGKVGVHCHAGLGRTGVLIACYLI--------YAKRFDGDHAIHFVREKRPGSIQTKGQVECCQQF
|. .||.|.|| .  . .||... .  .     ..|.| |||.||.||.|..||..|.        . ...|   |....||.|||..|| .| . . ..
fhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyea

AQFLIPLRV
 ..|.  . 
llellkkkl
0050432 (Phosphotyrosine protein) phosphatases II 141-232 4.4e-21 70.9 In-house 202-299 (308) alignment 
Range on Protein: 141-232
Range on HMM: 202-299/308.0
FYNFGWDDYGVKS-LTFILDMVKVMTFAVKEGKVGVHCHAGLGRTGVLIACYLI-----YAKRFDGDHAIHFVREKRPGSIQTKGQVECCQQFAQFLI
|.  .| |.|| . .. .||... .    ..|.. |||.||.||||..||..|.     . ...|  .|....||.|||..||. | . . . .....
fhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleyl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 141-224 4.4e-07 24.3 In-house 183-280 (325) alignment 
Range on Protein: 141-224
Range on HMM: 183-280/325.0
FYNFGWDDYGVK----SLTFILDMVKVMTFAVKE-----GKVGVHCHAGLGRTGVLIACYLIYAK-----RFDGDHAIHFVREKRPGSIQTKGQVECC
|   .||| ||.    .|  ||..|| .   |.      . . ||| ||.|||||.|. | . ||     | |    .. .|..||  ..|  |   .
fqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyili
subfamily_PTPRK_pd Subfamily PTPRK 141-224 2e-06 21.9 In-house 178-269 (314) alignment 
Range on Protein: 141-224
Range on HMM: 178-269/314.0
FYNFGWDDYGVK-SLTFILDMVKVMTF---AvKEGKVGVHCHAGLGRTGVLIACYLIYA-----KRFDGDHAIHFVREKRPGSIQTKGQVECC
|   || |..|  | | .|..|. .       ..|.. ||| || ||||. ||.  .       .  |  .|.. .|....  ..|. |   .
fqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfi
subfamily_PTPRD_pd Subfamily PTPRD 141-221 3e-06 21.2 In-house 182-270 (564) alignment 
Range on Protein: 141-221
Range on HMM: 182-270/564.0
FYNFGWDDYGVK-SLTFILDMVKVMTFA--VKEGKVGVHCHAGLGRTGVLIACYLIYA-----KRFDGDHAIHFVREKRPGSIQTKGQV
|.   | | ||  | | .||... .. .   ..| . ||| || ||||. |.   .       |  |    .. .|..|.  .||. | 
FhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQY
subfamily_PTPN13_pd Subfamily PTPN13 142-226 6.6e-10 33.7 In-house 171-263 (273) alignment 
Range on Protein: 142-226
Range on HMM: 171-263/273.0
YNF-GWDDYGVKSLT-FILDMVKVMT-FAVKEGKVGVHCHAGLGRTGVLIACYLIY-----AKRFDGDHAIHFVREKRPGSIQTKGQVECCQQ
 ||  | |.|| | .  .| .|. .  .. ..| . ||| ||.||.|.||. . .       | ||  . .. .||.| | .||| |   . .
lnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvyk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 142-221 7.1e-06 19.6 In-house 95-183 (440) alignment 
Range on Protein: 142-221
Range on HMM: 95-183/440.0
YNFGWDDYGVKSL-TFILDMVKVMTF---AVKEGKVGVHCHAGLGRTGVLIACYLI--YAKRFDGDHAIHF---VREKRPGSIQTKGQV
.  || | ||  .   .| |.. .      . .| . ||| || |||||.||   |   ||| |    . |   .|..||  .||  | 
hyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqy
Y_phosphatase Protein-tyrosine phosphatase 143-226 1.7e-09 32.8 Pfam-A 141-231 (235) alignment 
Range on Protein: 143-226
Range on HMM: 141-231/235.0
NfGWDDYGVK-SLTFILDMVKVMTFAV--KEGKVGVHCHAGLGRTGVLIACYLIYAK-----RFDGDHAIHFVREKRPGSIQTKGQVECCQQ
. .| |.||. | . .||... .      |.|.| ||| || ||||...|  ..  .      .|  ...  .|..|||..|.  | . . .
t.nWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflyk
Y_phosphatase Protein-tyrosine phosphatase 143-226 1.7e-09 32.8 In-house 141-231 (235) alignment 
Range on Protein: 143-226
Range on HMM: 141-231/235.0
NfGWDDYGVK-SLTFILDMVKVMTFAV--KEGKVGVHCHAGLGRTGVLIACYLIYAK-----RFDGDHAIHFVREKRPGSIQTKGQVECCQQ
. .| |.||. | . .||... .      |.|.| ||| || ||||...|  ..  .      .|  ...  .|..|||..|.  | . . .
t.nWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflyk
subfamily_PTPRA_pd Subfamily PTPRA 143-227 9.2e-07 23.0 In-house 198-290 (330) alignment 
Range on Protein: 143-227
Range on HMM: 198-290/330.0
NFGWDDYGVKSLTF-ILDM---VKVMTfAVKEGKVGVHCHAGLGRTGVLIACYLIYA-----KRFDGDHAIHFVREKRPGSIQTKGQVECCQQF
  .| | || . .  .|..   || .   .. | . ||| || |||| .|.   . .     .. |  .... .| .||  .||. | | . . 
ftswPdvGvPfepiGmlkllkkvkkln.qqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykv
PTPc_DSPc_SM00012 144-224 1.4e-12 43.1 In-house 8-99 (105) alignment 
Range on Protein: 144-224
Range on HMM: 8-99/105.0
FGWDDYGVKS-----LTFILDMVKVMTFAVKEGKVGVHCHAGLGRTGVLIACYLIYAKRFDG------DHAIHFVREKRPGSIQTKGQVECC
 || | || .     |... .. |... . ... | |||.|| ||||...| .... .  ..         .. .|..|||..||. |.  .
tgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfl
subfamily_PTPN12_pd Subfamily PTPN12 144-222 4.7e-08 27.3 In-house 178-267 (290) alignment 
Range on Protein: 144-222
Range on HMM: 178-267/290.0
FGWDDYGV-KSLTFILDMVKVMTFAVKEGK--VGVHCHAGLGRTGVLIACYLIYA--------KRFDGDHAIHFVREKRPGSIQTKGQVE
  | | || .| . .|.... .    .. .  . ||| || ||||..||  ...         ...|  . .  .|..|.  .||| | |
taWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqye
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 144-227 2.5e-07 24.9 In-house 160-259 (270) alignment 
Range on Protein: 144-227
Range on HMM: 160-259/270.0
FGWDDYGVKSLTF-------ILDMVKVMTFAVKEG----KVGVHCHAGLGRTGVLIA-----CYLIYAKRFDGDHAIHFVREKRPGSIQTKGQVECCQQF
  | | || . .        .| |.. .    ||      . ||| ||.||||.|||     . |   |. |  . |. .|..|.  .|.  |.|  .. 
ntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflyka
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 144-228 7.3e-07 23.7 In-house 193-286 (298) alignment 
Range on Protein: 144-228
Range on HMM: 193-286/298.0
FGWDDYGVK-SLTFILDMV-KVMTFAVKEG--KVGVHCHAGLGRTGVLIACYLIY-----AKRFDGDHAIHFVREKRPGSIQTKGQVECCQQFA
. | | ||    | .||.. || .   . |   | |.| || ||.|  || . .       .  |  .... .|.||||..||. |   . .  
tsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeav
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 144-222 1.8e-06 21.9 In-house 194-277 (305) alignment 
Range on Protein: 144-222
Range on HMM: 194-277/305.0
FGWDDYGVKSLTF-ILDMVKvmTFAVKEGKVGVHCHAGLGRTGVLIACYLIYAKR------FDGDHAIHFVREKRPGSIQTKGQVE
  | | || .    ||....     .  | . ||| ||.|||| ..    |  .        |.|. .  .||.|  ||||  |  
idwpdrgvpaadlailelle..karpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqyl
DSPc_SM00195 145-231 2.3e-10 35.6 In-house 167-261 (263) alignment 
Range on Protein: 145-231
Range on HMM: 167-261/263.0
GWDDYGVK-SLTFILDMVKVMTFAVK--EGKVGVHCHAGLGRTGVLIACYLIYAK-----RFDGDHAIHFVREKRPGSIQTKGQVECCQQFAQFL
.| | ||  | . .|.......   .  .| . |||.||.||||....  .|. |     ..| .. .  .|..|||..||. |   . . . ..
nWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 145-231 2.3e-10 35.6 In-house 167-261 (263) alignment 
Range on Protein: 145-231
Range on HMM: 167-261/263.0
GWDDYGVK-SLTFILDMVKVMTFAVK--EGKVGVHCHAGLGRTGVLIACYLIYAK-----RFDGDHAIHFVREKRPGSIQTKGQVECCQQFAQFL
.| | ||  | . .|.......   .  .| . |||.||.||||....  .|. |     ..| .. .  .|..|||..||. |   . . . ..
nWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 145-226 4.9e-08 27.4 In-house 184-274 (318) alignment 
Range on Protein: 145-226
Range on HMM: 184-274/318.0
GWDDYGV-KSLTFILDMVKVMTFAV---KEGKVGVHCHAGLGRTGVLIACYLIYaKRF------DGDHAIHFVREKRPGSIQTKGQVECCQQ
 | | || .| . .||.|.  . |    ..| . ||| || ||||| ||   .  .|       |  . .. .||.|.  .||. | | . .
sWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdill.erikaealvDvfqtvkqlreqrnlmvqtedqyefiyd
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 145-220 1.1e-06 22.6 In-house 192-271 (290) alignment 
Range on Protein: 145-220
Range on HMM: 192-271/290.0
GWDDYGVKSLT-FILDMVKVMTfaVKEGKVGVHCHAGLGRTGVLIAC-----YLIYAKRFDGDHAIHFVREKRPGSIQTKGQ
 | |  |   |  .| .....      | | ||| ||.|||| ..|       |.  | .|    .  .|. | .|.|   |
swpdksvalstlallrtlrilr..kasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiq
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 146-228 2e-06 22.2 In-house 147-238 (250) alignment 
Range on Protein: 146-228
Range on HMM: 147-238/250.0
WDDYGVK-SLTFIL---DMVKVMTFAVKEGKVGVHCHAGLGRTGVLIACYLIY-----AKRFDGDHAIHFVREKRPGSIQTKGQVECCQQFA
| | ||    | .|   . |.     .... | |.| || ||.|  || . .       |  |  . |. .|..||...... |   . . .
WPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeii
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 158-221 5.1e-06 20.8 In-house 205-273 (297) alignment 
Range on Protein: 158-221
Range on HMM: 205-273/297.0
LDMVKVMTFAVKEGKVGVHCHAGLGRTGVLIACYLIYAKRFDGD-----HAIHFVREKRPGSIQTKGQV
.. |.     ..|| . ||| ||.||||||..   . |.  . .       .. .|..||  .||| | 
isevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqy
subfamily_DSP12_pd Subfamily DSP12 160-213 2.4e-09 31.7 In-house 71-125 (155) alignment 
Range on Protein: 160-213
Range on HMM: 71-125/155.0
MVKVMTFAV-KEGKVGVHCHAGLGRTGVLIACYLIYAKRFDGDHAIHFVREKRPG
.|. .  |. .||.| |||.||. |   ... ||.. .... ..|...|.||.| 
avdFieealeeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkpe
subfamily_RNGTT_pd Subfamily RNGTT 164-217 9.7e-11 35.7 In-house 107-160 (189) alignment 
Range on Protein: 164-217
Range on HMM: 107-160/189.0
MTFAVKEGKVGVHCHAGLGRTGVLIACYLIYAKRFDGDHAIHFVREKRPGSIQT
      |  .||||. |  ||| ||..||.  . .. ..|..  .. ||  |  
ffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiyk
subfamily_DSP15_pd Subfamily DSP15 166-214 8.7e-07 23.1 In-house 74-122 (151) alignment 
Range on Protein: 166-214
Range on HMM: 74-122/151.0
FAVKEGKVGVHCHAGLGRTGVLIACYLIYAKRFDGDHAIHFVREKRPGS
  .||..| ||| ||. |   |.. ||. .  ..   |.......|  .
cRlkeenvlvhClaGvsRsvtlvvaYlmtvtelnwrdalevikaaRsva
subfamily_DSP19_pd Subfamily DSP19 167-215 3.9e-07 24.5 In-house 85-134 (152) alignment 
Range on Protein: 167-215
Range on HMM: 85-134/152.0
AV-KEGKVGVHCHAGLGRTGVLIACYLIYAKRFDGDHAIHFVREKRPGSI
|  |.| | |||.||  |.  ..  ||.  .. .  .|.. |||.||   
arskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpcik
subfamily_DSP1_pd Subfamily DSP1 168-216 1.1e-08 29.3 In-house 93-141 (163) alignment 
Range on Protein: 168-216
Range on HMM: 93-141/163.0
VKEGKVGVHCHAGLGRTGVLIACYLIYAKRFDGDHAIHFVREKRPGSIQ
 |.||| .||.||. |   |.  ||.  ||.  . | .||...|. .  
kknGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRsiisP
subfamily_DSP8_pd Subfamily DSP8 168-215 1.6e-06 21.8 In-house 91-137 (159) alignment 
Range on Protein: 168-215
Range on HMM: 91-137/159.0
VKEGKVGVHCHAGLGRTGVLIACYLIYAKRFDGDHAIHFVREKRpGSI
 ..|.| ||..||  |   .. .|..   ... |.| .||.|||  .|
sengrvlvhvlaGisrsatvaiayimktlemsldeayrfvkekr.pti
subfamily_DSP11_pd Subfamily DSP11 169-217 9.4e-08 26.1 In-house 115-163 (178) alignment 
Range on Protein: 169-217
Range on HMM: 115-163/178.0
KEGKVGVHCHAGLGRTGVLIACYLIYAKRFDGDHAIHFVREKRPGSIQT
..  .||||  |. ||| ||  |||  . .. ..||.   | |  |.. 
ndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhsler
subfamily_DSP10_pd Subfamily DSP10 169-212 9.9e-07 22.8 In-house 91-134 (159) alignment 
Range on Protein: 169-212
Range on HMM: 91-134/159.0
KEGKVGVHCHAGLGRTGVLIACYLIYAKRFDGDHAIHFVREKRP
|. .| |||.||. |   ..  ||.. ..    .| .||.||||
kgsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekrp
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 172-228 2.1e-06 21.9 In-house 230-291 (297) alignment 
Range on Protein: 172-228
Range on HMM: 230-291/297.0
KVGVHCHAGLGRTGVLIACYLIYAKRF-----DGDHAIHFVREKRPGSIQTKGQVECCQQFA
 . ||| ||.||.||.. .  | ||       |    ....||.|.  .||  | | . ...
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
RhoGAP RhoGAP domain 478-552 1.5e-06 15.3 Pfam-A 28-110 (152) alignment 
Range on Protein: 478-552
Range on HMM: 28-110/152.0
KQRVESLQHNLNQSQSAWKiVATEEDPFVLAALMWSWLEHLKEPVLQGKDVEKLVEY---------SGDLLKSLNLLEKYQKLT
|.||. |...... .....  ..|||. |.|.|.  .|. |.||.|  . .|.|.|             | . |. | | .  |
karvkelreafekgkavdl.dleeedvhvvaslLKrfLrelpepLltkelyeelleaaksedeeerlealkellekLPkenrat