Gene MTMR10 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR10
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP031_AA protein Get Run
SpurP031_AA_1-404 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_MTMR10_pd Subfamily MTMR10 1-405 2.7e-151 495.7 In-house 41-380 (380) alignment 
Range on Protein: 1-405
Range on HMM: 41-380/380.0
MPEFFVVPDPCSDYELKKASTNFEDCRVPFWCWSHRNGSMLMRMTAPS-DSIIENESEKWFLDSVIHIHPSKvHPDIIDIGKECPSIQELQSGYLKLQSM
.|..||||. .|| .....|  ... | |.|.||| .|. |.|..|    .....|.|.  | .| . ||.. .  ..|. .|.||||..|..||||...
lPqyfvvpnslsdsdverlsrhykesRfplwvwshakgaallrlsalqeaesadkekeekmlelvrkchpan.dvklvdlsdelpsiqdvqkaylklreL

CMPENIKDFWTTDEKWYSTLDSTKWLQTIGTCLSLAKEAADRIYIAEKTVIIKESQGRDYSCVVASLSQIMLDSHYRSQLGFQSLLQKEWIVAGHPFLDR
|.......|.|.|.||.|.|..|.||... .|||.| .|.. ..  ...||..||.|||.|||||||.|.|||.|||...|||||.||||..||||||||
cvidtseefvtlddkwlssLektrWLayvrlclstasdavktvvekkrsvilqesegrDlscvvaSLaqlmldphyrtisGfqsliqkewvaaghpfldr

CGHCVPSSGTESPIFLLFLDCVHQLIEQFPSAFEFTDTFLIALWDSMHSGIFGTFLFNSERHRMRTCVSSSkgqyqttqlatvwawtlqftkddqalftn
.||..||...|||.||||||||.||.|||||.||||.|||||||||.|||||.|||||||..|....||||                             
lghikpseksespvfllFldcvdqlleqfpseFeFtetfLialwdsshsgifltflfnseeqrlkavvsss.............................

PLYIAKSELKYNDLLDDEPDYRQGCNAGIYRSIRRLNNGKSYIGSdfkemdswtfnggkrrknpnvngansassvfanceeEIIIPLLQTPTITLWNHCY
||.|||||||.||||.||.|||||..|.|..|||||...|||..|                                    |||.||||.|.|.||..||
plliakselkendllkdeldyrqglyaeiiksirrlaaaksylrs....................................eiirPllqipdiqlWdeCY

LRWVPS
||||||
lRWvPs
0040695 (Phosphotyrosine protein) phosphatases II 2-404 1.7e-81 267.9 In-house 43-387 (388) alignment 
Range on Protein: 2-404
Range on HMM: 43-387/388.0
PEFFVVPDPCSDYELKKASTNFEDCRVPFWCWSHR-NGSMLMRMTAPSDSIIENESEK--WFLDSVIHIHPSKVHPDIIDIGK-----------------
| ..|||  .|| .||.... ... |.| ....|. ||..|.|.  |  ... ..| .   .|.......|.. .  |.|  .                 
PallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplvglllsrsledeklleailkllpnlskllivdlrpklnalanralgggvene

-----------ECPSIQELQSGYLKLQSMCmpenikDFWTTDEKWYSTLDSTKWLQTIGTCLSLAKEAADRIYIAEKTVIIKESQGRDYSCVVASLSQIM
           ..|.|. ... . ||...|      . . .. ...| |....||..| ..|.||..... .   .  |.. .| |.|. ... ||.|..
daypnaeliflnipnihvvreslqklldac......lnvpdslnllslleesgwldliklilelavlivklldlgnssvlvhcsdgwdrtsqlssLaqll

LDSHYRSQLGFQSLLQKEWIVAGHPFLDRCGHCVP--SSGTESPIFLLFLDCVHQLIEQFPSAFEFTDTFLIALWDSMHSGIFGTFLFNSERHRMRTCVs
||..||.  |||.|..|||. .||.|.||.|| .   .|  .||.||||||||.||. |||.||||....|. |.|...|..|||||||||. |.. .| 
ldPyYRTleGFqvLiekeWlsfghkfadRlghleseidskefsPvFllFLdcvwqLlrqfPtaFeFnerlLlfLadhlyscrfgtFlfnsekerlelsv.

sskgqyqTTQLATVWAWTLQFTKDdqalFTNPLYIAKSelkyndllddepdyrqgcnagiyrsirrlnngksyigsdfkemdswtfnggkrrknpnvnga
        ... ..| . |.....    |.||||   |                                                              
.......sertlslwsyllsrkse....flnplYdpss..............................................................

nsassvfanceEEIIIPLLQTPTITLWNHCYLRWVP
           .|...|.|. ....||. .||||.|
...........levllpslsvldlllWleyylrwlp
Myotub-related Myotubularin-like phosphatase domain 2-56 2.3e-11 36.0 Pfam-A 57-112 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 2-56 2.3e-11 36.0 In-house 57-112 (353) alignment
subfamily_MTMR5_pd Subfamily MTMR5 2-47 2.5e-08 25.2 In-house 47-93 (483) alignment 
Range on Protein: 2-47
Range on HMM: 47-93/483.0
PEFFVVPDPCSDYELKKASTNFEDCRVPFWCWSHR-NGSMLMRMTAP
|  .|||. .|| .... . .|.. |.|  .| |. |...|.| ...
PalivvPsevsddsiarvakcfrqnRlPvvtWrhernkalLiRsggf
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 2-53 2.5e-07 22.2 In-house 52-104 (404) alignment 
Range on Protein: 2-53
Range on HMM: 52-104/404.0
PEFFVVPDPCSDYELKKASTNFEDCRVPFWCWSHR-NGSMLMRMTAPSDSIIE
|. .|||  .||.||||...  .  |.|  .| || ..| ..|   |   . .
PkllvvPesisDeelkkvasfRskgRiPvlswrhrsknstitRssqplvGltk
subfamily_MTMR9_pd Subfamily MTMR9 2-50 6.8e-06 17.4 In-house 50-99 (393) alignment 
Range on Protein: 2-50
Range on HMM: 50-99/393.0
PEFFVVPDPCSDYELKKASTNFEDCRVPFWCWSH-RNGSMLMRMTAPSDS
|| ..||.  .| |||. ..  |. |.|  .. | .....|.| . |. .
pesvivPkaiddeelkasaafreggrfPvLsylhketkavllrssqplcg
subfamily_MTMR5_pd Subfamily MTMR5 81-304 9.5e-47 151.9 In-house 233-457 (483) alignment 
Range on Protein: 81-304
Range on HMM: 233-457/483.0
KECPSIQELQSGYLKLQSMCMPENIKDFwTTDEKWYSTLDSTKWLQTIGTCLSLAKEAADRIYIAEKTVIIKESQGRDYSCVVASLSQIMLDSHYRSQLG
 | . |..... . ||  .|.|..  .  .. . ......   ||| | . | |.  ..| . . .  |..   .|.|    |.||.|..||..||.  |
velveirqvkasfkkllraClpstavee.aesqsFlksvedseWlqqissllqlsgavvdlldlqgssvlvslEdGwdvtaqvsslaqllldpyYRtleG

FQSLLQKEWIVAGHPFLDRCGHCVPSSG-TESPIFLLFLDCVHQLIEQFPSAFEFTDTFLIALWDSMHSGIFGTFLFNSERHRMRTCVSSSKGQYQTTQL
|. |..|||.  || | .|. .   ... . .|.|| |||||||. .||| |||| | .|  |     |  | |||..|| .|. . .  .. ... .. 
FkvLveKEWLafGHrFtkrsnqtlsaqssgfaPvFlqFLDcvhqvsrqfPlafefndfylkflayhsvsnrfrtfllDseyerlesgllyeekaekrakk

--ATVWAWtLQFTKDDQALFTNPLYIA
   .|| . .. ..   ..| | ||  
agksvwdy.idrqhkrspifynflysp
Myotub-related Myotubularin-like phosphatase domain 82-263 2.9e-59 193.6 Pfam-A 171-351 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 82-263 2.9e-59 193.6 In-house 171-351 (353) alignment
subfamily_MTMR9_pd Subfamily MTMR9 82-305 3.9e-54 176.2 In-house 158-369 (393) alignment 
Range on Protein: 82-305
Range on HMM: 158-369/393.0
ECPSIQELQSGYLKLQSMCMPENikdfwTTDEKWYSTLDSTKWLQTIGTCLSLAKEAADRIYIAEKTVIIKESQGRDYSCVVASLSQIMLDSHYRSQLGF
.  |....|. . ||   |. ..     .. .|..| |....||...   |..|. .|. ..  ...|......| | ...|.||.|..||...|   ||
slesvasiqdslaklleacsdag.....lstdkflsrleksgwlsqvadlleaalvvaqcldeegapvvvhgeeGlDatlqvtsLaqlildpdaRtvrgf

QSLLQKEWIVAGHPFLDRCGHCVPSS---GTESPIFLLFLDCVHQLIEQFPSAFEFTDTFLIALWDSMHSGIFGTFLFNSERHRMRTCVSSskgqyQTTQ
..|...||| |||||  |. ... ..    ...|.||||||||.|...||| .||| ...||.|.   .|  ||||| ..|..| .. ...     .|..
ealiereWiqaGHPFasRaskvaaketkkklsgpvfllFLDcvyqilsqfpasFEFneelLillfehsyssqfgtflcdneaerkelklkk.....ktvs

LatvWAWTlqFTKDDQALFTNPLYIAK
|   |..    ...    |.|||| | 
l...wsyv..nrpeklkqflnplyean
subfamily_MTMR1_pd Subfamily MTMR1 84-305 1.6e-57 187.6 In-house 156-361 (389) alignment 
Range on Protein: 84-305
Range on HMM: 156-361/389.0
PSIQELQSGYLKLQSMCMPEnikdfwTTDEKWYSTLDSTKWLQTIGTCLSLAKEAADRIYIAEKTVIIKESQGRDYSCVVASLSQIMLDSHYRSQLGFQS
..|. ..  . ||. ...|.      . |.||.|.|.|||||. | . |. | . .... . ...|..  |.| |    . ||....|||.||.  ||. 
hnihvvReslkklkelvlpn......vddkkwlsalestkWlehiklilagavkivekvetektsvlvhcsdGWDRtaqltsLamlllDsyyRtieGfev

LLQKEWIVAGHPFLDRCGHCV--PSSGTESPIFLLFLDCVHQLIEQFPSAFEFTDTFLIALWDSMHSGIFGTFLFNSERHRMRTCVSSskgqyQTTqlaT
|..|||.  ||.| .| ||     |   .||.|| |.|||.|| .|||.||||...||| | | ..|..|||||||||..|... |..     .|.   .
liekeWlsfGHkfkeRlghgdknssdaersPvFlqfiDcvwqltrqfptAFefneefLitlldhlysclfGtflfnsekervkekvke.....ktv...s

VWAWtlqfTKDDQALFTNPLYIAK
.|..     . ..  ||||||  .
lwsy....vnsskeeftnplyaee
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 85-402 4.4e-51 166.3 In-house 166-402 (404) alignment 
Range on Protein: 85-402
Range on HMM: 166-402/404.0
SIQELQSGYLKLQSMCmpENIK-DfwttDEKWYSTLDSTKWLQTIGTCLSLAKEAADRIYIAEKTVIIKESQGRDYSCVVASLSQIMLDSHYRSQLGFQS
 |.||.  . ||. ..  ..|. .    ...|.| |.|..||. | . |. .|.... |   .. |... |.| |  . ..||||..||..||   ||..
nihelreslkklkkav..nsiiek....eknwlselessrWldhiklllegskriveliekekssvlvhcsdgwDrtsqlsslsqllldpyyrtiegFiv

LLQKEWIVAGHPFLDRCGH-CVPSSGTESPIFLLFLDCVHQLIEQFPSAFEFTDTFLIALWDSMHSGIFGTFLFNSERHRMrtcvssskGQYQTTQLATV
|..|||.  || | .|.|.    ||  .||||| |.|||.||..|||. ||| . ||| . |.. |. |||||..||..|          .  ....  .
liekewlsfGhkfaqRigqttekssdersPiflqFidcvyqltkqfptsFeFnekflikildalyscrfgtFLydsekeRq........qnnlaketvsl

WAwtlqFTKDDQALFTNPLYIAKSELKYNDLLDDEPDYRQgcnagiyrsirrlnngksyigsdfkemdswtfnggkrrknpnvngansassvfanceeei
||      . ..  . |||||.... ...    .| .  .                                                            
Wa....lleankseylnplyilekkeqkenitssessssa............................................................

iipllQTPTITLWNHCYLRW
     .  .|.||.. ||||
.....dikliklWseyylrw
subfamily_pats1_pd Subfamily pats1 104-202 2.7e-12 37.9 In-house 359-459 (691) alignment 
Range on Protein: 104-202
Range on HMM: 359-459/691.0
NIKDFWTTDEKWYSTLDStKWLQTIGTCLSLAKEAADRIYIAEKTVIIKESQGRDYSCVV---ASLSQIMLDSHYRSQLGFQSLLQKEWIVAGHPFLDRC
.| ..  .|..| .. .| ||. ..   |. | . .  .   .  .. . ... ..   .   .||.|...| .||.  ||. |..|||.  |.|| ...
silsldgsddewkeiees.kwvdsvkllleaavkvsnlldeGssvllknsidsPlieldlasisslaqvlsdPfyrtldGfkvliekewlsyGfPfskin

GH
 |
yh
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 105-268 4.2e-38 123.1 In-house 192-355 (405) alignment 
Range on Protein: 105-268
Range on HMM: 192-355/405.0
IKDF-WTTDEKWYSTLDSTKWLQTIGTCLSLAKEAADRIYiAEKTVIIKESQGRDYSCVVASLSQIMLDSHYRSQLGFQSLLQKEWIVAGHPFLDRCGHC
 ||   .|| ... ... | |.  | . |  |  .|. |    ...... |.| | .  ..||.||.|| .||.  ||| |..|||.  || |  | || 
dkdhtestdmrfwgyieetgwishiksileaatfsaelil.kgnsilvhcsdgwdrtpqitsltqilldpyyrtivgfqvliekewlsfghkfslrlghl

VPSSGTESPIFLLFLDCVHQLIEQFPSAFEFTDTFLIALWDSMHSGIFGTFLFNSERHRMRTCVS
       ||||  ||||. ||..|||  |||| ..|. . | .||  .|||| | |. |..  | 
pgneeerspifqqfldccfqllsqfpllfeftpslllfisdnihsckygtflnncekdrvqdqvk
subfamily_MTMR3_pd Subfamily MTMR3 111-306 1.7e-48 158.5 In-house 234-419 (442) alignment 
Range on Protein: 111-306
Range on HMM: 234-419/442.0
TDEKWYSTLDSTKWLQTIGTCLSLAKEAADRIYIAEKTVIIKESQGRDYSCVVASLSQIMLDSHYRSQLGFQSLLQKEWIVAGHPFLDRCGHC--VPSSG
 . .|.|.|..||||| . . |  | . .. .   ...|..  | | |    . .|....|| .||.  ||. |...||.  || | |||||   |  ..
desnwlsalektkWlqnlsvllkaavkvveavdkegrpvlvhCsdGWdrttqivalakllldpyyrtleGfkvlvereWldfGhkfadrcghgenvddan

TESPIFLLFLDCVHQLIEQFPSAFEFTDTFLIALWDSMHSGIFGTFLFNSERHRMRtcvssskgQYQTTQLATVWAwtlqFTKDDQALFTNPLYIAKS
  .|.|| .||.|||| .|||..|||...||. |    .|..|||||.|||..| .        .  ....  ||.    . . ..  ..| ||  |.
ercPvflqwldavhqlqrqfPtsfefneaflvklvqhtysclfGtflansekeree........ekvkertlsvWs....llrakekeyrnllykekt
subfamily_MTMR6_pd Subfamily MTMR6 111-308 6.2e-45 146.1 In-house 188-373 (397) alignment 
Range on Protein: 111-308
Range on HMM: 188-373/397.0
TDEKWYSTLDSTKWLQTIGTCLSLAKEAADRIYIAEKTVIIKESQGRDYSCVVASLSQIMLDSHYRSQLGFQSLLQKEWIVAGHPFLDRCGHCVPSSGTE
. ....|.|.|..||. | . |  .   |  ..  ...|..  | | | .. |.||....||..||.  ||. |..|||.  || | .|||.   .|   
svseflsglessgwlkhikavldasifiakavaeegasvlvhcsdGwdrtaqvcslasllldpyyrtikGflvliekewlsfGhkfsercGlldedskev

SPIFLLFLDCVHQLIEQFPSAFEFTDTFLIALWDSMHSGIFGTFLFNSERHRMRTCVSSskgqyQTtqlATVWAWTLQFTKDdqalFTNPLYIAKSEL
||||. ||.|| ||.|||| |||| ..||..| | ..|  ||||| |.|..|  . ..      .|    ..||. |. ..|    ..|||| |..| 
sPiftqflecvwqlleqfpkafefnerfllelhdhvyscqfGtflgncekdrrdlklke.....rt...kslwayllerkdd....ylnplykaetek
subfamily_pats1_pd Subfamily pats1 211-302 2.2e-14 44.8 In-house 553-632 (691) alignment 
Range on Protein: 211-302
Range on HMM: 553-632/691.0
SPIFLLFLDCVHQLIEQFPSAFEFTDTFLIALWDSMHSGIFGTFLFNSERHRMRTCVSSSkgqyqtTQlaTVWAwtlqFTKDDQALFTNPLY
||||. ||| | ||  .||  ||| . .|. | .  .|. ||.||..  ....   | ..      ..  ..|.    | . ... |.| ||
sPifvqfldlvwqlqkefPfhfefneslllllvkesfssrfGnflyseakrdserkvlkr......sk..siws....finqnksrfinlly
3-PAP Myotubularin-associated protein 359-440 1.3e-16 51.1 Pfam-A 54-134 (142) alignment 
Range on Protein: 359-440
Range on HMM: 54-134/142.0
RRKNPNVNGANSASSVFANcEEEIIIPLLQTPTITLWNHCYLRWVPSVHTVGGGSPAIYQQQCRLVDEIQQLRETLENLKVS
.... .  ....|||| |.  .... | .  . . ||  |||||.| ....|||......... |..||. |...||  . |
spataseqlsktassvPad.lhqlLlpqqlgldlslWsqcylRwiPeaeikgggqvqvdlklselleeiaklqrlleqrdms