Gene PTPRB-5 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRB
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP071_AA protein Get Run
SpurP071_AA_541-869 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
fn3 Fibronectin type III domain 18-97 1.2e-10 34.5 Pfam-A 2-81 (85) alignment
Range on Protein: 18-97
Range on HMM: 2-81/85.0
AVGNISVTQYATTTADVQWNLMQ-CSDCIYNYFLLTFEPDSQEpIRVDYTTGVNEYSYQVSGLTEGRNYNFTVVSVSGVGV
|..|.||..  .|.. ..|.  .  .. | .| .   | ...|   . .|.  ...|....||..|..|.|.| .|.|.| 
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge.ewkeftvprtttsvtltgLkpgteYefrVqavngage

fn3 Fibronectin type III domain 205-243 2.8e-06 20.6 Pfam-A 1-39 (85) alignment
Range on Protein: 205-243
Range on HMM: 1-39/85.0
SPVGNPQAEAVDKNTITLTYESPLEPNGDITGYRISYIG
|...|.....|  ...||. . | ...|.||||.. |  
saPenlsvsevtstsltlsWsppkdgggpitgYeveyre

subfamily_PTPRB_pd Subfamily PTPRB 493-719 2.9e-122 402.3 In-house 2-228 (293) alignment
Range on Protein: 493-719
Range on HMM: 2-228/293.0
SHSKPIVLNKFEGHYGRMKADSDFRFTEEYDEIRLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQG
..||||.|.|||.|. .||||||.||.|||.|...||||||...| ..|||||||.||||||.|||||||||.|.|..|||||||||||||||||.|.||
kkskpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqG

PLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYNPVTYGSIQVSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPEKTWTM
|||.||||.|||.||||.||||||||||||||.||.||||||..||.||.|.|...| .....|||||..|....|.||..||||.|||||||||||.|.
PlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktl

LDFVRTVREAIQKTASDRPIVAHCSAG
|||||||||||.||||.||||.|||||
ldfvrtvreaiektaskrPivvhCsaG

0039614 (Phosphotyrosine protein) phosphatases II 494-719 9.1e-71 234.0 In-house 10-232 (297) alignment
Range on Protein: 494-719
Range on HMM: 10-232/297.0
HSKPIVLNKFEGHYGRMKADSDFRFTEEYDEIRLVGKDqaIVSALEMVNRAKNRFTNILPYEHSRVKLAALAD-DSDTDYINANYIPGYNS-PREFMACQ
 | || |. .. .....||.|  .. .|. |.  .  |  .. ||  .|. |||...||||.||||||  . . | |.|||||.|..||.  .|.| |.|
esipiplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatq

GPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKiKCHEYWPADYNpvTYGSIQVSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPEKTWT
||||.||.| |||.|| ....|||||.|||.|. ||..||| . .  ||| ..| .   ...|....|..... ..| |..|......|||||||. . .
gPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslel

MLDFVRTVREAIQKTASDRPIVAHCSAG
.|.|.. ||||.... ...|.. |||||
lleflelvrealaelpkggpvlVHCsaG

0045450 (Phosphotyrosine protein) phosphatases II 494-719 2.1e-68 226.7 In-house 5-244 (307) alignment
Range on Protein: 494-719
Range on HMM: 5-244/307.0
HSKPIVLNKFEGHYGRMKADSDFRFTEEYDEIRLVGK--DQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADD-SDTDYINANYI--------PGYN
.|..| . |.. .. ....|.  .. .|. ... | .     . .||  .|. |||...||||.|.||||  | .. .|.|||||.|.        .||.
lslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgyd

SPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYNPVTYGSIQVSVQALQQYDHWVIREFSIS---QGDEIRKLTQYHFMS
..|.|.|.|||||.||.| |||.||.....|||||.|||.|..||..||| .  ..||| ..| .   ...|....| . ..   . .| |..|..|. .
lkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytg

WPDHGVPEKTWTMLDFVRTVREAIQKTASDRPIVAHCSAG
|||||||. . ..|||.. ||.|.... .. |.. |||||
wpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaG

subfamily_PTPRD_pd Subfamily PTPRD 495-719 5.2e-87 287.8 In-house 2-224 (564) alignment
Range on Protein: 495-719
Range on HMM: 2-224/564.0
SKPIVLNKFEGHYGRMKADSDFRFTEEYDEIRLVgKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPL
||||  .... |. ..||.||..|.||| .|.   .   . .| . .|.||||. ||..|.||||.| ..  |...|||||..| ||.......| ||||
skpipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPl

PGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADyNPVTYGSIQVSVQALQQYDHWVIREFSIS--QGDEIRKLTQYHFMSWPDHGVPEKTWTM
. |..| |||.||...|.|||||.|.|||| |||.|||.. .. |||...|.... ... . .||.|...  . .| |. .|.||.|||||||||.. ..
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.gtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatsl

LDFVRTVREAIQktASDRPIVAHCSAG
||..|.||.. .      ||| |||||
Ldlirkvralne..pdagPivVhCSaG

subfamily_PTPRA_pd Subfamily PTPRA 495-720 1.4e-65 216.4 In-house 11-239 (330) alignment
Range on Protein: 495-720
Range on HMM: 11-239/330.0
SKPIVLNKFEGHYGRMKADSDFRFTEEYDEIRLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPL
  |. ..|.|    . .||   .| ||.. .     . ..  | .  |. |||. |||||..||| |. .    ..||||| .| ||.   .|.|.|||.
yfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPk

PGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADyNPVTYGSIQVSVQALQQYDHWVIREFSIS-QGDE-----IRKLTQYHFMSWPDHGVPEK
  ||.|.||||||.|.. |||||.| |. . ||. ||| .   |||| |.|.|.  .   .. .|.| .  ..|.      | ..|.|| |||| ||| .
eetvedfwrmiweqksativmltelkerkeekcaqywPde.GlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfe

TWTMLDFVRTVREAIQKTASdrPIVAHCSAGA
.  ||.... |..  |..|.  ||| |||||.
piGmlkllkkvkklnqqsag..pivvhcsaGv

0051299 (Phosphotyrosine protein) phosphatases II 496-719 1.3e-75 249.8 In-house 3-229 (288) alignment
Range on Protein: 496-719
Range on HMM: 3-229/288.0
KPIVLNKFEGHYGRMKADSDFRFTEEYDEIRLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLP
..| ..... .. ...|..  .. ||..|.. .  |  . .||   |. |||...||||.||||||  | .....|||||.||.|||..|.|.|.|||||
teisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlp

GTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPAdYNPVTYGSIQVSVQALQQYDHWVIREFSIS------QGDEIRKLTQYHFMSWPDHGVPEKT
.||.| |||.||.....|||||.|||.|..||. |||   ...||| |.|     ...|....|.. ..      ...| |. |..|...|||||||. .
ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

WTMLDFVRTVREAIQktASDRPIVAHCSAG
  .|||.| ||.|..  ... |.| |||||
ellldflrlvrkala..sgggpvvVHCsaG

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 496-720 8.1e-71 233.7 In-house 3-227 (319) alignment
Range on Protein: 496-720
Range on HMM: 3-227/319.0
KPIVLNKFEGHYGRMKADSDFRFTEEYDEIRLVGKDqAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLP
..| ..... .. .... ..  . .|. ...  ..|  . || .  |. |||..|||.|...||.|..| .  ..|||||..| ||.  ..|.| |.|| 
teievqeLkerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPle

GTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADyNPVTYGSIQVSVQALQQYDHWVIREFSISQ-GDEI--RKLTQYHFMSWPDHGVPEKTWTM
 |..|.|||.||...||.||||.||||.|.|...|||   |...|| . | ..  .. ....||.... .  .|.  |.........||||.||||. ..
ntiedfWrmvWeeessivvmltklveklkvklkkywpee.nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatsl

LDFVRTVREAIQKTaSDRPIVAHCSAGA
||... .|.. .|| ...||| |||||.
ldllkrirksrekt.qsgPivvhCsaGv

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 496-720 9.4e-63 207.0 In-house 4-223 (315) alignment
Range on Protein: 496-720
Range on HMM: 4-223/315.0
KPIVLNKFEGHYGRMKADSDFRFTEEYDEIRlVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLP
.|| |...  .  . || .   | ..|. |   |. . .  | .. |. |||. ||..|..|||.|  |  |...||.|||.|.||| .| ..|.|||..
qpipldqlityvaqkkastkngfkqdyesip.ggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnv

GTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADynPVTYGSIQVSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPEKTWTMLDF
 .|.|.||...|.. . |||||.|||. | |. .||| .   |.|| | |. .  ...... .| .|.  ||.||.. |.|. |||| |||. | .....
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnl

VRTVREaiQKTASDRPIVAHCSAGA
.|||.    .|.|  .|| ||||| 
irtvkq..hhtnsvgaivvhcsaGv

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 496-719 2.1e-60 199.4 In-house 2-226 (305) alignment
Range on Protein: 496-719
Range on HMM: 2-226/305.0
KPIVLNKFEGHYGRMKADSDFRFTEEYDEIRLVgKDQAIVsALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLP
|.| |.... .   ....||  . ..|...    ...  |   . .|.||||...| .....|..|..  .. |.|||||.|. ||..  .... ||||.
kiialddlaayikearvysdkgleaqykslyee.eesidv.gkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlk

GTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYNP-VTYGSIQVSVQALQQYDHWVIREFSISQ---GDEIRKLTQYHFMSWPDHGVPEKTWT
 ||.| ||.|.| |.| |||||.||| || ||. |||   .  . .|...| ..  ...  ...|...||.    .| | ..||.. .|||||||... .
ntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfats

MLDFVRTVREAiQKTASDRPIVAHCSAG
.|.... |... ||   . |.. |||||
llslikrvqkd.qkkdkgvpllVhCsag

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 496-719 2.3e-51 169.7 In-house 8-227 (297) alignment
Range on Protein: 496-719
Range on HMM: 8-227/297.0
KPIVLNKFEGHYgRMKADSDFRFTEEYDEirLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSprEFMACQGPLP
.|| | .|     . . ..|.   |  .   .  . |.   | . ||  |.|..|||||. |||||| . || | ||.|| ...|..   .... | | .
rpiplsdfatlv.qknrhtdvfseeflcl..peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmk

GTVDDMWRMIWEKKTSIIVMLTQLVEKGKiKCHEYWPaDYNPVTYGSIQVSVQALQQYDHWVIREFSISQGD--EIRKLTQYHFMSWPDHGVPE--KTWT
 ||.|.|.|......|.||||... |. | ||  ||. |   .|.|.. | ......    . ||.....|.    | . ||.|..|||. |..  .. .
atvadfWamvldeqvstivmlnddnerdk.kcaryWs.dkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsass

MLDFVRTVREAIQKTASDrPIVAHCSAG
.|...  ||.  ...|.  |.. ||.||
llklisevrkdfsqnaeg.PllvhclaG

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 496-592 1.9e-14 47.6 In-house 3-95 (95) alignment
Range on Protein: 496-592
Range on HMM: 3-95/95.0
KPIVLNKFEGHYGRMKADSDFRFTEEYDEIRLVGKDQAIVSALEmVNRAKNRFTNILPYEHSRVKLAAladDSDTDYINANYIPGYNSPREFMACQG
||| .  |  |   |...||  | .|.  | .       | . |  |  |||| ||.||. .|| |..     |.||||| .. ||     ..|.||
kpihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsse.anipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaqg

subfamily_Ptp69D_pd Subfamily Ptp69D 497-720 8.4e-59 194.2 In-house 3-230 (307) alignment
Range on Protein: 497-720
Range on HMM: 3-230/307.0
PIVLNKFEGHYGRMKADSDFRFTEEYDEIRLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPG
.| . . |  .   | |.|| ...||...     |.  . . .  |  |||. .| .... ||||. .  . |.|||||..| ||.  ..|.| |.|. .
aiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPvea

TVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADyNPVTYGSIQVSVQALQQYDHWVIREFSISQGD-------EIRKLTQYHFMSWPDHGVPEKT
|..| ||||.|..  .||||..| || . ||. ||| . . | ||.| | .   .. ....|||...|. .       . ||..|||...|.|  ||| .
tigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPeva

WTMLDFVRTVREAIQKTasDRPIVAHCSAGA
 ..|.... |||  ..     ||| |||||.
rgllklieqvrelykln..rsPivvhCsaGv

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 498-719 6.3e-77 253.7 In-house 2-223 (318) alignment
Range on Protein: 498-719
Range on HMM: 2-223/318.0
IVLNKFEGHYGRMKADSDFRFTEEYDEIRLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGT
| ....| |  |.... .  ..|||...  . .  . . .|| ||.||||..|||.|.|.||||  |... ..||||||||.||.. ....|.|.||| |
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

VDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADyNPVTYGSIQVSVQALQQYDHWVIREFSISQ--GDEIRKLTQYHFMSWPDHGVPEKTWTMLDF
..|.|||.||.....||||||..|.||.|.| ||| . .. .||...| ..   .....|.|||....   .| |.  |||. ||||.||||.. ..||.
ieDfWrmvWeqnsavivmltqeeergkakvhryWPsk.gsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldl

VRTVREAiQKTASDRPIVAHCSAG
||.|..| |.... .||| |||||
vrqvska.qqksgagpivvhCsaG

subfamily_PTPRG_pd Subfamily PTPRG 499-722 8.5e-67 220.6 In-house 2-233 (563) alignment
Range on Protein: 499-722
Range on HMM: 2-233/563.0
VLNKFEGHYGRMKADSDFRFTEEYDEIRL--VGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDT-DYINANYIPGYNSPREFMACQGPLP
 ...|. |   ..||.| .|.||....    . ||  . .. .  |. ||| .||..|..|||||. |..  .. |||||||| ||.  ..|.| ||||.
pvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplk

GTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPAdYNPVTYGSIQVSVQALQQYD-----HWVIREFSISQGDE---IRKLTQYHFMSWPDHGVPE
 |.|| ||||||....||||.|.|||.|. ||. |||.  ...|||..||  .. ..       . ||... . ....    .. .|||. .||||||||
dtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe

KTWTMLDFVRTVREAiqKTASDRPIVAHCSAGAIK
..   | ||.    |  . |   ||| |||||. .
hslpvLifvkkssaa..nkaeaGPivvHcsaGvgr

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 500-719 2.3e-48 159.5 In-house 4-226 (290) alignment
Range on Protein: 500-719
Range on HMM: 4-226/290.0
LNKFEGHYGRMKADSDFRFTEEYDEIRLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSD--TDYINANYIPGYNSPREFMACQGPLPGT
..||  .    .|  . .| ...  .    .....  .|   |. .|||.||..|.  |. |  .... |   .|||| || ||.  ....| |||.. |
vdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsnt

VDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYNPVtYGSIQVSVQALQQYDHWVIREFSISQGDE---IRKLTQYHFMSWPDHGVPEKTWTMLD
. | |..||..|..||||||. .|.|| ||. |||.  .   || ... ..  ..... ..|.... . ..    ...|||.. .|...|  ... |.| 
lvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtill

FVRTVREaIQKTASDRPIVAHCSAG
 .. . . .|.   ...|| |||..
vieemyk.tqrkrgntsivvHCSdt

0040438 (Phosphotyrosine protein) phosphatases II 502-719 8.7e-69 227.5 In-house 4-219 (317) alignment
Range on Protein: 502-719
Range on HMM: 4-219/317.0
KFEGHYGRMKADSDFRFTEEYDEIRLVGKDqAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDM
... .. .... .  .. ||. ... . .|  .  |.  .|. |||...||||.||||||  |  | |.|||||.|..|.| .|.| |.|||||.||.| 
dlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedF

WRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPAdYNPVTYGSIQVSVQALQQYDHWVIREFSIS--QGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTV
|||.|| ....|||||.|.|.|..||..|||   ...||| ..| ..  ........|.. ..  ...| |..|..|...|||||||. . ..|||.. |
wrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleav

REAIQktASDRPIVAHCSAG
|||..   .. |.. |||||
reale..dpggpvlVHCsaG

0043336 (Phosphotyrosine protein) phosphatases II 502-719 2.8e-67 222.4 In-house 6-220 (278) alignment
Range on Protein: 502-719
Range on HMM: 6-220/278.0
KFEGHYGRMKADSDFRFTEEYDEIRLVGKdQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDM
... .. ......  .. .|. |.. . .   .  || . |. |||...||||.||||||  |  | |.|||||.|..||| ||.| |.|||||.||.| 
dllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedF

WRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPadYNPVTYGSIQVSVQALQQYDHWVIREFSIS--QGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTV
|||.|| ....|||||.|||.|..||..|||   ...||| ..| ..  ...|....| . ..  . .| |. |.||...|||||||| . ..|||...|
wrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkav

REAIQktASDRPIVAHCSAG
|||..   |. |.. |||||
reale..dsngpvlVHCsaG

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 502-720 1.9e-43 143.5 In-house 6-223 (439) alignment
Range on Protein: 502-720
Range on HMM: 6-223/439.0
KFEGHYGRMKADSDFRFTEEYDEIRLVGKDQAIVSALE--MVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVD
.|. |  ... . .  |.|....|  .  | | ...|     ...|||. .. ...|.|| |  .     . ||||||| ||  .. ..|.|||   |.|
efqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettd

DMWRMIWEKKTSIIVMLTQLVEKGKikcheYWPADYNpVTYGSIQVSVQALQQYDHWVIREFSIS----QGDEIRKLTQYHFMSWPDHGVPEKTWTMLDF
|.||...||||. |||||.|||  |     |||.| . | || | | |.   .  ..||| | .     ...  | . |.|...|||. || ..  .|||
dfwrlviekktvtivmltnlvesyk.....ywpsdae.vcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldf

VRTVREAIQKTASdRPIVAHCSAGA
.|..  | .|     |.| ||||| 
lrainsandkeey.gpvvvhcsagv

0050432 (Phosphotyrosine protein) phosphatases II 505-719 1.5e-72 239.9 In-house 31-242 (308) alignment
Range on Protein: 505-719
Range on HMM: 31-242/308.0
GHYGRMKADSDFRFTEEYDEIRLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLaaladDSDTDYINANYIPGY--NSPREFMACQGPLPGTVDDMW
 ..  .||..  .. ||. |.. |  .  . .||   |. |||...||||.||||||     |...|||||.|..||  ..||.| |.|||||.||.| |
llkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFw

RMIWEKKTSIIVMLTQLVEKGKIKCHEYWPAD--YNPVTYGSIQVSVQALQQYDHWVIREFSISQ--GDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRT
||.|| ....|||||.|||.|..||..||| .   ....|| ..| .   ...|....|.. ..   ..| |..|..|...|||||||...  .|||.. 
rmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflel

VREAIqktaSDRPIVAHCSAG
||. .    .. ||| |||||
vrksl....pggpivVHCsaG

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 505-719 4.9e-70 230.8 In-house 10-222 (288) alignment
Range on Protein: 505-719
Range on HMM: 10-222/288.0
GHYGRMKADSDFRFTEEYDEIRLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRM
 .  ...|..   |.|||. .  ..|...   . . ||  |||. |||||.. ||||  | . ...|||||.|| |... ....| ||||. ||.| |..
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

IWEKKTSIIVMLTQLVEKGKIKCHEYWPADYNPVTYGSIQVSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQ
..|.||| |||||.|||.|| ||.||||.. .|. |||..| ..  .. ...| |.. . .  . ...|||....|||||||| .  .|...|.|  | |
vyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanq

KTasDRPIVAHCSAG
.     ||. |||||
ad..tgpiivhCsaG

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 505-719 8.2e-51 168.0 In-house 12-231 (325) alignment
Range on Protein: 505-719
Range on HMM: 12-231/325.0
GHYGRMKADSDFRFTEEYDEIRLVGkDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRM
 |  . ||. .  |. |.. .  ..  .|   |    |.||||| |......||| | .. ||...|||||.|.  .     |.|.| ||. |..|.||.
ehvekkkaqdqdgfahefgllpsdd.giakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrl

IWEKKTSIIVMLTQLvEKGKIKCHEYWPAD-YNPVTYGSIQVSVQALQQYDHWVIREFSISQG--DEIRKLTQYHFMSWPDHGVPEKTWTMLD---FVRT
. . ..|..|.| .| ..|| .|  ||| .  . .|.|...|........  .| | . . |    | | . |....||.| ||...  |..     | .
vldWrcsvvvvlnel.dlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvka

VREAIQK-TASDRPIVAHCSAG
| | ..  | .  ||. |||||
vservtantkastpilvhcsaG

subfamily_PTPRK_pd Subfamily PTPRK 506-720 4.8e-59 194.7 In-house 12-221 (314) alignment
Range on Protein: 506-720
Range on HMM: 12-221/314.0
HYGRMKADSDFRFTEEYDEIrLVGkdqaIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMI
.   .|.   . | |||. . . |      .| .  ||.|||...||.|..|||.| .. .|...|||||..| .|. |..|.. ||||. || |.||..
siallkraegygfkeeyesl.feg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlv

WEKKTSIIVMLTQLVEKGKIKCHEYWPADYNPvtYGSIQVSVQALQQYDHWVIREFSISQ----GDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVRE
...... |||||.|||.|..|| .||| | .   || |.| .   .     |.| |....     .|||.. |..|..||||.|| .  ..|..|| | .
ydencasivmltelvevgrvkClkyWPedtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkk

AIQKtaSDRPIVAHCSAGA
  ..  .. .|| ||||||
sqee..eaGrivvhCsaGa

0047943 (Phosphotyrosine protein) phosphatases II 510-719 3.6e-71 235.2 In-house 6-215 (273) alignment
Range on Protein: 510-719
Range on HMM: 6-215/273.0
MKADSDFRFTEEYDEIRLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLaalaDDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKK
.|...  .. ||..... . ..  .  ||   |. |||...||||.||||||    .|...|||||.|..|||..|.|.|.|||||.||.| |||.||..
ekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqn

TSIIVMLTQLVEKGKIKCHEYWPADYN--PVTYGSIQVSVQALQQYDHWVIREFSISQ--GDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQK
...|||||.|||.|..||. ||| . .  ..||| ..| .   ...|....|.. ..    .| |. |..|...|||||||. .  .|.|.. ||.|...
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalea

TASDRPIVAHCSAG
. |. |.| |||||
lpsngpvvVHCsaG

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 510-719 1.6e-69 229.1 In-house 9-218 (281) alignment
Range on Protein: 510-719
Range on HMM: 9-218/281.0
MKADSDFRFTEEYDEIRLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKK
......  |.|||.... .| |.. ... .  |. |||..||  |...|||..   ....|||||||..|||....|..|.|||.| .....|.|.||.|
lsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqk

TSIIVMLTQLVEKGKIKCHEYWPADYNPVTYGSIQVSVQALQQYDHWVIREFSI-SQGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAiQKTAS
 |.|||.|. .|.||.||| ||| | . ..|| ..|. .| ..  ... |.|..  .. | |...| ....|||||||..|  .|.| . |... ... .
vsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkl.tekkt

DRPIVAHCSAG
. |.| |||||
kaplvihCsaG

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 510-720 5.9e-61 201.3 In-house 21-234 (298) alignment
Range on Protein: 510-720
Range on HMM: 21-234/298.0
MKADSDFRFTEEYDEIRLVGK---DQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIW
.|. .  ....|. ... | .   ..    | .  |. |||...|.....||| | .  .| ..||||| .. .|.    |.|.|.||. || | |||..
kkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvt

EKKTSIIVMLTQLVEKGKIKCHEYWPADyNPVTYGSIQVSVQALQQYDHWVIREFSISQGD--EIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREaIQ
|.. . |||||.|.|..|.|.|.||| . .  |||.|.||... ...   ..|.. .|. .  . |.. | ||.||||.||||.. ..||..| ||   |
eedigtiVmltnleeldktkyhkywPde.gketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sq

KTASDRPIVAHCSAGA
. | ..|.. .|||| 
qqagnkpvivqCsaGv

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 510-719 7.6e-46 151.4 In-house 14-221 (287) alignment
Range on Protein: 510-719
Range on HMM: 14-221/287.0
MKADSDFRFTEEYDEIRLVGKDQA-IVSALEMVNRAKNRFTNILPYEHSRVKLAaladDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEK
 .| ..  |.. .  .  |....  .  ..   |. |||.|.||...  || |     . . ||||| .| ||.. ..|.....|.  |. ..|..|...
ghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddr

KTSIIVMLTQLVEKGKIKCHEYWPADYNpVTYGSIQVSVQALQQYDHWVIREFSISQGD---EIRKLTQYHFMSWPDHG-VPEKTWTMLDFVRTVREaiQ
. ..||||.|. |. . .|..||| . . |..|  ....   ........|.. . . .   . ....||.. .|...| |.|.   .| . . ...  |
nvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemykt..q

KTASDRPIVAHCSAG
.  .. .|| |||..
rkrgntsivvhCsdt

0036941 (Phosphotyrosine protein) phosphatases II 511-719 9.9e-69 227.2 In-house 8-217 (297) alignment
Range on Protein: 511-719
Range on HMM: 8-217/297.0
KADSDFRFTEEYDEIRLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLaalaDDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKT
|...  .. .|..|.  . ..  .  ||   |. |||...||||.|.||||    ||...|||||.|..||. .|.|.|.|||||.||.| |||.|| ..
kllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnv

SIIVMLTQLVEKGKIKCHEYWPAD-YNPVTYGSIQVSVQALQQ--YDHWVIREFSISQ--GDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQK
..|||||.|||.|..||..||| .  ...||| ..| ..  ..  .|....|.. ..   ..| |..|..|...|||||||| . ..|||.. ||.....
tvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkl

TASDRPIVAHCSAG
. |. |.. |||||
lpsggpvlVHCsaG

0045098 (Phosphotyrosine protein) phosphatases II 512-719 1.3e-61 203.8 In-house 3-216 (278) alignment
Range on Protein: 512-719
Range on HMM: 3-216/278.0
ADSDFRFTEEYDEIRLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKlaaladdsdtDYINANYIPGYnsPREFMACQGPLPGTVDDMWRMIWEKKTS
|... ... |.....| |  . |  ||   |..|||...||||.|||||          |||||.||.||  |..| |.||||| ||.| |||.|| ...
alasldlllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgit

IIVMLTQLVEKGKIKCHEYWPaDYNPVTYGSIQVSVQALQQYDHWVIREFSIS------QGDEIRKLTQYHFMSWPDHGVPEKT--WTMLDFVRTVREAI
.|||||.|||.|..||..||| . ...||| ..| ..  ...|....| . .       ...| |..|..|...|||||||. .  . .|.... .|||.
vivmltelvelgrekcaqywp.eggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefireal

Q-----------KTASDRPIVAHCSAG
.              |. |.. |||||
kllaslllsslllldsggpvlVHCsaG

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 513-720 2.3e-23 77.5 In-house 3-203 (267) alignment
Range on Protein: 513-720
Range on HMM: 3-203/267.0
DSDFRFTEEYDEIRLVGKDQAI-VSALEMVNRAKNRFTNILPYEHSRVKLAaladDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTS
|..  . .|...|. . ....     . . |...||. . |||...|| |     ... .|||| |. ||.  . |.. |.||  |. | . .| ..| .
deeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilr....tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvp

IIVMLTQlVEKGKIKchEYWPAD-YNPVTYGSIQVSVQALQQYDHWVIREFSI-SQGDEIRKLTQYHFMSWPDHgVPEKTWtmLDFVRTVREAIQKTASD
.||.||. | ...|.   .||    .   |  . |     .. . . |  . .  . .  ...| |..  |    . .| .  |  .  .    |    .
vivlltk.vftdnir..lfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwnin.tnnkpy..lkplfgilaknqlengn

RPIVAHCSAGA
||.| .||.| 
rPlvvacsdGv

subfamily_PTPN1_pd Subfamily PTPN1 516-719 2.2e-48 159.4 In-house 6-211 (290) alignment
Range on Protein: 516-719
Range on HMM: 6-211/290.0
FRFTEEYDEIRLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAaladDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVM
 ...| | .||   .|  . .| .  ||..||. .. ||.|||.||     ..|.|||||. .   .  |...  ||||| ||| .|.|.||.|.  .||
rlykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikle....radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvm

LTQLVEKGKIKCHEYWPADYN--PVTYGSIQVSV--QALQQYDHWVIREFSISQ--GDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQKTASD
| ..|||..|||..||| . .   ...  ....|   . ........| . . .   .| |.....|...||| ||||   ..|.|.  |||.   .   
lnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdv

RPIVAHCSAG
 | | |||||
GpavihcsaG

subfamily_PTPN6_pd Subfamily PTPN6 517-719 2.2e-61 202.5 In-house 27-237 (306) alignment
Range on Protein: 517-719
Range on HMM: 27-237/306.0
RFTEEYDEIRLVGKDQAI--VSALEMVNRAKNRFTNILPYEHSRVKLAaLADDSDTDYINANYIP--GYNSPREFMACQGPLPGTVDDMWRMIWEKKTSI
 |.||..|..   . . .    .  . |. |||. ||||..|.||.|.   . ...||||||||     .| ....| || |. || | |||.|.... .
gfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrv

IVMLTQLVEKGKIKCHEYWPADYNPVTYGSIQVSVQALQQYDHWVIREFSIS---QGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQKTA--
|||.|. ||.|| ||  |||.  .  .||.|.|.  . .. .....||.|.|   ...| |.. |||| ||||||||... ..|||...|..  ....  
ivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleea

SDRPIVAHCSAG
. .||| |||||
eagpivvhCsaG

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 517-719 1.4e-37 124.1 In-house 16-236 (301) alignment
Range on Protein: 517-719
Range on HMM: 16-236/301.0
RFTEEYDEIRLVGKDQAIVSALEmVNRAKNRFTNILPYEHSRVKLAAL--ADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIV
.| |.|.|.. . .....|.  |  |.| ||| || .|.. |. |.     | . ..||||.|| ||.. ..|.| |||.  |. |.||.||..|.. ||
kfeeqykelkegedksctvglse.enkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsiv

MLTQLVEKGKIKCHEYWPA-DYNPVTYGSIQVSVQALQQYDHWVIREFSI-----------------SQGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFV
|.|.| |. | ||..|||  . .  ..| ..| ..  | |  .|||....                 ..  . ....|..  .||..||     |.|  .
mvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqvi

RTVREAIQKTaSDRPIVAHCSAG
  |  . ||  .  |.| |||..
ddvihrqqki.gggpvvVHCSdt

0046845 (Phosphotyrosine protein) phosphatases II 518-719 2.3e-71 235.8 In-house 2-214 (284) alignment
Range on Protein: 518-719
Range on HMM: 2-214/284.0
FTEEYDEIRLVGKDQ--AIVSALEMVNRAKNRFTNILPYEHSRVKLAALADD-SDTDYINANYIPGY-----NSPREFMACQGPLPGTVDDMWRMIWEKK
. ||. |.. .  ..   .  ||   |. |||...||||.||||||  | .| .|.|||||.|..||     .....|.|.|||||.||.| |||.||..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

TSIIVMLTQLVEKGKIKCHEYWPADYNPVTYGSIQVSVQALQQYDHWVIREFSISQ---GDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQKT
...|||||.|||.|..||. ||| . ...||| ..| .   ...|....|.....    ..| |..|..|..||||||||. .  .|.|.|.|||.....
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

ASDRPIVAHCSAG
 .. ||| |||||
pgggpivVHCsaG

DSPc_SM00195 518-719 1.6e-63 209.8 In-house 2-205 (263) alignment
Range on Protein: 518-719
Range on HMM: 2-205/263.0
FTEEYDEIRLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLT
. ||.....   ... . .| .  |..|||..|||||.|.||||    .....|||||||| |.|..... |.||||| ||.| |||.||.|..||||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

QLVEKGKIKCHEYWPADY-NPVTYGSIQVSVQALQQYD-HWVIREFSISQGD--EIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQKTasDRPIV
. .|.||.||..||| .  .. |.|.|.| ..  .... ....|...... .  | ||.|||.. .|||||||..|  .|...|.|..  ...  . |||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpiv

AHCSAG
 |||||
VhCsaG

PTPc_SM00194 518-719 1.6e-63 209.8 In-house 2-205 (263) alignment
Range on Protein: 518-719
Range on HMM: 2-205/263.0
FTEEYDEIRLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLT
. ||.....   ... . .| .  |..|||..|||||.|.||||    .....|||||||| |.|..... |.||||| ||.| |||.||.|..||||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

QLVEKGKIKCHEYWPADY-NPVTYGSIQVSVQALQQYD-HWVIREFSISQGD--EIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQKTasDRPIV
. .|.||.||..||| .  .. |.|.|.| ..  .... ....|...... .  | ||.|||.. .|||||||..|  .|...|.|..  ...  . |||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpiv

AHCSAG
 |||||
VhCsaG

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 518-720 2.3e-57 189.2 In-house 21-221 (315) alignment
Range on Protein: 518-720
Range on HMM: 21-221/315.0
FTEEYDEIRLVGKDqAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLT
|.||. ..          .| | .|  |||. ||||....||||  . |. | ||||| ||..... . ..| ||||. .|||.|||....|.. |||.|
fseefhdlpdPdiy.rqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvt

QLVEKGKIKCHEYWPA-DYNPVTYGSIQVSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAiqKTASDRPIVAHC
.. |  ||||  |||  . . | .|||.|..  |..    |.|.. . ...| |..||..|  |||.||...| ..| ... |.    .   . ... ||
kkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad..ngkkefsllvhc

SAGA
|||.
saGv

subfamily_PTPN23_pd Subfamily PTPN23 518-719 3.4e-50 165.5 In-house 23-222 (288) alignment
Range on Protein: 518-719
Range on HMM: 23-222/288.0
FTEEYDEIRlvGKDQAIvsALEMVNRAKNRFTNILPYEHSRVKLAaladDSDTDYINANYIPGYNS--PrEFMACQGPLPGTVDDMWRMIWEKKTSIIVM
  |....     ....|  |.  ..  |||...||||.|.||||     .|  ||||| .. .  .  | .|.| |.||..|. | |.|..|.|.|.|||
eleqkqdke..arkrsi..aiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcP.dfiatqaPlqstlnDFWlmvyeqkssviVm

LTQLVEKGKIKCHEYWPADY-NPVTYGSIQVSVQALQQYDHWVIREFSIS--QGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVRE--AIQKTASDR
|..  |.|| |...|||.|  ..|..| ..|...  .. ...| |.....  . |......  ...|||..|||.   |.|.|.  |..    ..  |. 
llskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrkskt

PIVAHCSAG
|.| |||||
PlvvhCsaG

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 518-720 1.6e-41 137.0 In-house 22-180 (392) alignment
Range on Protein: 518-720
Range on HMM: 22-180/392.0
FTEEYDEIRLVGKDQAiVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLT
|.||. ..      .   .| . .|  |||. |||||. .||||  . | .|.||.|| |||.... . ..|.||| . ..||.|||....... |.|.|
ffeefhdlpgpdiypq.tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvt

QLVEKGkikcheywpadynpvtygsiqvsvqalqqydhwvirefsisQGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVReaIQKTASDRPIVAHCS
.| |                                           .||. |  .|.||  |||..||..| ..| |.. |.  ..     .|.. |||
klkegd.........................................kgddartvaqfhftewPdkdvpkhtssllkfikevk..adfGqythpliihcs

AGA
|| 
agv

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 518-720 3.9e-20 66.8 In-house 21-220 (312) alignment
Range on Protein: 518-720
Range on HMM: 21-220/312.0
FTEEYDEIRLVGKDQAIVSALEMvnRAKNRFTNILPYEHSRVKLAAladDsDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLT
.| ||  .  .  |    . | .  .  ||. ||  ..  |  ||    | .  || ||..     |  |...||||  |.  .|..     .. |..|.
ltkeykavgnivsdsectaflkf..kdlnrypniqcwdrgrftlag...d.enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillc

QLVEKGKIKCHEYWPADYNPVT----------YGSIQVSVQALQQYDHWVIREFSISQGDEiRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVReaiqKta
 .|| |  || .|       |              |..  .. ..  | |..    . |.|  || .| . ||||||.|.   | | .. .|.    |  
gfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqe.sklnhyqwaswpdhgmpdscdtalrllsavk....k..

SDRPIVAHCSAGA
  .|..|||||| 
dkkpviahcsagv

subfamily_PTPN9_pd Subfamily PTPN9 519-719 2.4e-58 192.5 In-house 19-233 (297) alignment
Range on Protein: 519-719
Range on HMM: 19-233/297.0
TEEYDEIRLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQ
..|| |||       .  .   .|  |||.|..| |...||.|| . .|. .||||||.. ||. .. |.| ||||. ||.| |||.||... .||| |.
skeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttr

LVEKGKIKCHEYWPA-DYNPVTYGSIQVSVQALQQYDHWVIREFSIS--QGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQ-----------
.||.|..|| .|||  . .   .|...||.   ........| . |.  . .|.||.| . |.||||.|||. . ..||....|||.             
vvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewk

KTASDRPIVAHCSAG
  .|. ||| |||||
ghpsgPPivvhcsaG

subfamily_PTPN13_pd Subfamily PTPN13 519-719 1.2e-54 180.5 In-house 14-212 (273) alignment
Range on Protein: 519-719
Range on HMM: 14-212/273.0
TEEYDEIRLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADdsdtdYINANYIPG--YNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVML
.||..|.| .   .   .. .  |..|||. |.|||...|||| . .      ||||..|     .   |..||||||| ||.|.|.|.||.|...|.|.
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv

TQLVEKGKIKCHEYWPADYN-PVTY-GSIQVSVQALQQYDHWVIREFSIS--QGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREaIQKtaSDRPI
|. .||||.||| |||   | ...  . ..|..  .|..| .|.|.. ..  .  | |.... .|..||||||| ..  .| ||. ||. .|.  .  ||
tlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrr.lqt..dagPi

VAHCSAG
| |||||
vvhcsaG

subfamily_PTPN14_pd Subfamily PTPN14 519-720 1.4e-44 147.4 In-house 26-240 (300) alignment
Range on Protein: 519-720
Range on HMM: 26-240/300.0
TEEYDEIRLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDsDTDYINANYIPGY--NSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVML
  ||..|    .|  . .|   .|  |||| ..||||..||.|..  .. .|.||||  |      . |.....||||. || |.|.|.||.....||||
fteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivml

TQLVEKGKIKCHEYWPAD---YNPVTYGSIQVSVQALQQYDHWVIREFSISQ--GDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQKTASDR-
|.  |.|| |...|.| .    . |..|  .|. .  .. |  . . . .      | |..    .. ||||||||   ..|.... |.   .|| | . 
teeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseve

------PIVAHCSAGA
      |.. |||||.
skeskPPvlvhCsaGv

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 520-719 3e-36 119.8 In-house 13-209 (283) alignment
Range on Protein: 520-719
Range on HMM: 13-209/283.0
EEYDEIRLVGKDQAIVSAleMVNRAKNRFTNILPYEHSRVKLAALADdsdtDYINANYIP---GYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVML
| .... .  .|  | ||    |. |||. .|.|..  ||.| ...     ||||| .||    |.  ......|.||  || |.|.|....| . ||||
evlkrlsvpdldadiasa..denkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivml

TQLVEKGKIKCHEYWPADyNPVTYGSIQVSVQALQQYDHWVIREFSISQG---DEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVreAIQKTASDRPIV
|.| |  .|||  ||| .   . ||   |...     . ..|.|. . .     .   |. | .  | . |      ... | . .  . |.   . |||
tklqedlrikCsqyWPkr.GsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvi..slqteskkgPiv

AHCSAG
 |||.|
vhCstg

subfamily_PTPN3_pd Subfamily PTPN3 521-719 8.6e-57 187.2 In-house 20-218 (280) alignment
Range on Protein: 521-719
Range on HMM: 20-218/280.0
EYDEIRLVGKDQAIVSALEMVNRAKNRFTNILPYEHSRVKLaalaDDSDTDYINANYI----PGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVML
.....    .. ||  |    | .|||. .||||.. ||||    ..|.||||||||.    |. .    ..|.||||. |. |.|.|.||.|.|.||||
qfeqlyrkkpglaisaarkpenlsknryrdilpydatrvkl....kesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivml

TQLVEKGKIKCHEYWPADYNPVTYGSIQVSVQALQQYDHWVIREFSISQGD--EIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAiqKTASDRPIVA
|.|||.|..|||.|||   . ..||...| ..  ..   .|.||. ... .  | ||..|  ...|||||||...  .|.||..||..  ......|.| 
ttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrkl..rsgkeePvvv

HCSAG
|||||
hCsaG

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 524-719 3.6e-30 100.0 In-house 21-219 (307) alignment
Range on Protein: 524-719
Range on HMM: 21-219/307.0
EIRLVGK---DQAIVSALEmVNRAKNRFTNILPYEHSRVKLAalADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLV
|.| . |   .   | |..  |  |||....   ...|. .    |   .||| |||.     |. |...||||  |. ..| |. ..|   ..|| ...
efrvlakktpegvtveafs.antdknryqdvkcqdkgrivvk..fdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvi

EKGKIKCHEYWPADY-NPVTYGSIQ--VSVQ-----ALQQYDHW-VIREFSISQGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREaiqktaSDRP
| .||||..|||..  .  ..|.    .||.      |   ..   . .. .  ... | .... .  |||.|||.   | .... .||          |
elakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry......dtnp

IVAHCSAG
.| |||||
vvvhcsaG

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 528-723 2e-25 84.2 In-house 37-228 (301) alignment
Range on Protein: 528-723
Range on HMM: 37-228/301.0
VGKDQaIVSALEMVNRAKNRFTNIlPYEHSRVkLaALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKC
. ||. |  ..  ... |.|. .. | . |   .  . .|     | ||.||    |. |.| ||||. | .|.| |.   .   ||||.| ||| . ||
idkdh.itesyaylpkdkhryptv.PckPsta.v.evivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekc

HEYWPADY-NPVTYGSIQVSVQALQQY--DHWVIREFSISQG---DEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREaiqktaSDRPIVAHCSAGAI
.|| | .  . .  |  .. ..  ..   .. . |.. .       . | .| | ...|.|.|||.    . |..  |..      |..||| |||||  
eeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk......sekPivvhcsaGiG

KC
. 
rs

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 530-692 9e-36 118.2 In-house 21-186 (297) alignment
Range on Protein: 530-692
Range on HMM: 21-186/297.0
KDQAIVSALEMVNRAKNRFTNILPYEHSRVKLAALAddSDTDYINANYI--PGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKC
. ..  ||       |||...|| .. .||||      ...|||||.|.  |  ...  ..  ||||  |||| |....|.   .|||...| | |. ||
rgesfssakrnsslrknryrdilatddtrvkllrvi..terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkc

HEYWPA-DYNPVTYGSIQVS--VQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPEKTWTM
  |||  . .  . |.. |    .  ...|. .. |. .   .| |...   |.||||||||     .
apywpsvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledl

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 530-633 4.6e-26 86.4 In-house 37-152 (350) alignment
Range on Protein: 530-633
Range on HMM: 37-152/350.0
KDQAIVSALEMvnRAKNRFTNILPYEHSRVKLAA--------LADDSDTDYINANYIPGY------NSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVM
 |  . . .|.   ||||..||||||||||||              |  |||||||.         |.   ..| |.||| ||||....| . |  .|..
nDvilseGvel..faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvils

LTQLVEKGKIKCHEYWPA
||..|| .  ||..||. 
ltsdvelnlekcyrYWqe

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 530-649 5e-19 62.8 In-house 38-167 (349) alignment
Range on Protein: 530-649
Range on HMM: 38-167/349.0
KDQAIVSALEMVnrAKNRFTNILPYEHSRVKLAAL------ADDSD--------TDYINANYI--PGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSII
.|  . . .|.   ||||. .|||||||||||         .. |          |||||||.  . ..  . ..| | ||| |||| ...|  ..  ..
ddvilseGvelf..aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklv

VMLTQLVEKGKIKCHEYWpadyNPVTYGSIQVSVQA
. |..  |..  ||. ||    .  .| .|.| .| 
lsLnddkelslekcdiyw....qelsysnitvklqn

0049772 (Phosphotyrosine protein) phosphatases II 532-719 3.8e-31 104.4 In-house 36-222 (314) alignment
Range on Protein: 532-719
Range on HMM: 36-222/314.0
QAIVSALEMVNRAKNRFTNILPYEhSRVKLaALADDSDTDYINANYIPGYnspREFMACQGPLPGTVDDM----------WRMI--WEKKTSIIVM----
. |. |   .|| |||...|||.. .||.|    . |..|||||.|. |.   . |.|.||||. ||.|           |||.  .. .. .|||    
ltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrde

-----------------LTQLVEKGkikcHEYWPADYNPVTygsiqvsvqalqqydhwvirefSIS--QGDEIRKLTQYHFMSWPDHGVPeKTWTMLDFV
                 |..| ..|     |...||.                          ..   . .  |   .|. . .||...|  .  ...|.
vladelsrLdaAlgKtpllildgng....neptaadlellk......................eelydpelferlgikylripvpDgsap.lledfdefl

RTVREAiqktASDRPIVAHCSAG
. ..||      ..|.. ||.||
efieea....dkggpvlvHCkaG

subfamily_CG42327_pd Subfamily CG42327 533-704 7.8e-32 105.2 In-house 17-195 (319) alignment
Range on Protein: 533-704
Range on HMM: 17-195/319.0
AIVS--ALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYN-SPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHE
 | .  .. .  . |.|. |..|  ..|| |   .||  . |..|.|. ||. .|  ..|.| .|  .  |.||..||... .|| ||.| |.|  .| |
liaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcae

YWPAD---YNPVTYGSIQVSVQALQQYDHWVIREFSIS--QGDEIRKLTQYHFmSWPDHGVPEKTWTMLDFVRTVREAIQ
|.|.     |  .|| |.|...  .  |...|  . .   ...| |.|| | .  |.. .|| .  ...  .  ||....
ylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrsslk

subfamily_egg_pd Subfamily egg 533-653 1.2e-18 61.8 In-house 31-152 (307) alignment
Range on Protein: 533-653
Range on HMM: 31-152/307.0
AIVSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKgkIKCHEYWP
..  |..  |. | |   .   . |||||         |.| ||.. |     ||. .| ||  ||||.|||.....   |||||  .|    .|. |||
slttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywp

A-DYNPVTY--GSIQVSVQALQQY
  . ... .  ||...    ... 
kaesdslvtvpGslrienlkvdsk

subfamily_PTPN12_pd Subfamily PTPN12 535-719 5.7e-62 204.2 In-house 33-217 (290) alignment
Range on Protein: 535-719
Range on HMM: 33-217/290.0
VSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPAD
 .. ...|..|||. .||||..|||.|    .. . ||||||.| | ... |..| ||||| |.|| |||||||...|.||. ..|| ||.||. |||  
eagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpee

-YNPVTYGSIQVSVQALQQYD-HWVIREFSISQGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQktASDRPIVAHCSAG
  .....|...|.... .. |  ..|| . . . .| ||..|.|...|||||||... ..|.....|||  .  ..| |.| |||||
geeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaG

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 535-720 8.6e-59 194.0 In-house 36-220 (515) alignment
Range on Protein: 535-720
Range on HMM: 36-220/515.0
VSALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPA-
  | | .|  |||. |||||. .||||  . |. . ||.|| |||.... . ..| |||.. .|||.||........ |.|.|.| |  |||| .|||  
tvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdk

DYNPVTYGSIQVSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQKTAsdRPIVAHCSAGA
  . | .|||.|.. .|.     ..|.. . .||..| .||.||  |||.|||..| ..| ... |.   .. .   |.. |||||.
pgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt..hpliihcsaGv

subfamily_eak_pd Subfamily eak 535-700 9.4e-16 52.1 In-house 47-208 (332) alignment
Range on Protein: 535-700
Range on HMM: 47-208/332.0
VSALEMVNRakNrFTNILPYEHSRVKLAALADDSDtDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPAD
 . || |||  |   .|.||..  |.|..   . .  ||||  .   .  |...    .    |  .|.|. |.|.  ||.| . ||..  |   |.| .
tarleavnr..n.vvkivpydrylvrltssqlnrl.GyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdk

Y-NPVTYGSIQVSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPEKTwTMLDFVRTVR
  . . .| ..|  .   . .    | . .|.|.|  ..  |..  | .  .|     .| . ....
treelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkye.dflalrkvmk

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 535-581 4.5e-07 23.7 In-house 32-77 (244) alignment
Range on Protein: 535-581
Range on HMM: 32-77/244.0
VSALEMVNRAKNRFTNILPYEHSRVKLAAlADDSDTDYINANYIPGY
..|.  .| .|||. ||||....|| |.. .    .|||||||| | 
tnavlsanatknryinilpfdetrvilss.skkegsdyinanyiqgs

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 536-720 8.5e-43 141.2 In-house 32-221 (287) alignment
Range on Protein: 536-720
Range on HMM: 32-221/287.0
SALEMVNRAKNRFTNILPYEHSRVKLAALAdDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADY
.| |. .  |||....||....|| |.| . .  .|||||||...|.   .|.|.|||.. || |.||...|.... ....|. ||... ||..|||   
aaeelaavkknryadvlPiddtrvllsaeg.elGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPere

NPVTYGSIQVSV--QALQQYDhWVIREFSISQ--GDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVR---EAIQKTASDRPIVAHCSAGA
 |.  |   | .  .  .. . . .| . . .  . | | . |....||||....  .  .. ||  |.   |. ....   |.| |...|.
vPmrvGGysvvlldydikePe.ygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGi

subfamily_PTPRN_pd Subfamily PTPRN 536-720 1.1e-40 134.2 In-house 50-235 (297) alignment
Range on Protein: 536-720
Range on HMM: 50-235/297.0
SALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYnSPRE--FMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPA
 | .  |  ||| ...|||.|||||| . |.....|||||  |     ||.  ..|.||||. || |.|.|.||. . .||.||.| |.|  .|..||| 
vakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildh.dprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpd

DYNPVtYGSIQVSVQAL-QQYDHWVIREFSIS--QGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQKTASdrPIVAHCSAGA
. . | |.  .| . .     | ...| | .   | .| | .||.||.|||..||| .. ..|.| | |  . .  ..  ||| |||.||
eGsev.yhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrsc..pivvhcsdGa

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 536-583 4.2e-08 27.0 In-house 41-88 (440) alignment
Range on Protein: 536-583
Range on HMM: 41-88/440.0
SALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNS
 |    |. |||. ||| |.|||| |  .    |.||||| || | .|
iaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingies

0037934 (Phosphotyrosine protein) phosphatases II 537-719 1.2e-57 190.6 In-house 5-188 (243) alignment
Range on Protein: 537-719
Range on HMM: 5-188/243.0
ALEMVNRAKNRFTNILPYEHSRVKLaaladdSDTDYINANYIPGYnsPReFMACQGPLPGTVDD----MWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWP
|| ..|. |||...||||.||||||      ...||||||.|...  || . |.|||||.||.|     |||.|| ....|||||.|||.|..||..|||
allpenlsknrysdilpydhsrvkl......egsdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

adyNPVTYGSIQVSVQALQQYDHWVIREFSISQ---GDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQK------TASDRPIVAHCSAG
   ..|||| ..| .   ...|....|.....    .|. |  ..||...|||||||. .  .|||.. ||| |..        |..|.. |||||
...gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

subfamily_CG7180_pd Subfamily CG7180 537-720 4.5e-38 125.6 In-house 37-234 (296) alignment
Range on Protein: 537-720
Range on HMM: 37-234/296.0
ALEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKiKCHEYWPADYn
.|.  || |||  ...||.. || |  |  ....||||| |. ..  ..|..  ..|   |||. ||.......| .|.||.  .  | ....||| .  
glrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.

PVTYGSIQVSVQALQQYDHWVIREFSISQG------------DEIRKLTQYHFMSWPD-HGVPEKTWTMLDFVRTVREAIQKT---ASDRPIVAHCSAGA
   || | | .   .|| . .||.| . .              | | ......  |.  . ||  | ......| ||  ..|.       |.| ..| ||
keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGa





subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 538-720 3.2e-45 149.2 In-house 4-185 (239) alignment
Range on Protein: 538-720
Range on HMM: 4-185/239.0
LEMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYN-SPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYn
 . ||.||||..||. |.|||| |  |..|  .|||||.|.  |. ||. ..| || .  .  |.|||.|...  .||||| |.|  | |||.|||    
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.

pVTYGSIQVSVQALQQYDHWVIREFSISQG--DEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAiqKTASDRPIVAHCSAGA
   |  ..|...  . .  ..|| | .||    | | . ||||  |||.|||. . ..| . | . .        || | ||||| 
.skycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkd..slpgarpwvihcsagv

0040439 (Phosphotyrosine protein) phosphatases II 539-719 1.1e-61 203.9 In-house 8-189 (249) alignment
Range on Protein: 539-719
Range on HMM: 8-189/249.0
EMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPAdYNPV
 ..|. |||...||||.||||||  | .  ..|||||.||.||...|.| |.|||||.||.| |||.|| . ..|||||.|||.|..||..|||   ...
lpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.ggsl

TYGSIQVSVQALQQYDHWVIREFSIS--QGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQKTASDRPIVAHCSAG
.|| ..| .   ...|....|.. ..  . .| |. ..... .|||||||. . ..|||.. ||.|.... .. |.. |||||
eygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaG

0042113 (Phosphotyrosine protein) phosphatases II 539-719 4.1e-61 201.8 In-house 6-186 (245) alignment
Range on Protein: 539-719
Range on HMM: 6-186/245.0
EMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPAdYNPV
 ..|. |||...||||.|.||||     | |.|||||.|..||. .. | |.|||||.||.| |||.|| . ..|||||...|.|..||..|||   ...
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.gesl

TYGSIQVSVQALQQYDHWVIREFSIS--QGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQKtASDRPIVAHCSAG
||| ..| .   ...|....|.....  . || |. ..||...|||||||. . ..|||.. ||.|...  |. |.. |||||
tygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaG

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 539-720 3.7e-56 185.1 In-house 6-186 (250) alignment
Range on Protein: 539-720
Range on HMM: 6-186/250.0
EMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIkCHEYWPADyNPV
.. |. |||...|.....||| |     | ..||||| .. ||.  . |.| ||||. |. |.|||..|.|.. |||||.|.|..|  .|.|||.. .. 
kpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve.kae

TYGSIQVSVQALQQYDHWVIREFSISQGDEIRK--LTQYHFMSWPDHGVPEKTWTMLDFVRTVReAIQKTASDRPIVAHCSAGA
.||...||.   ...  ...|.. .|.  .  .  . |.||..||| ||||.. ..|.... |. | |. | ..|.. .|||| 
kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvq.asqqqagnaPvivqCsaGv

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 539-719 4.4e-45 148.7 In-house 4-183 (239) alignment
Range on Protein: 539-719
Range on HMM: 4-183/239.0
EMVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYN-SPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYnp
. ||.||||..||. |.|||| |  |..|  .|||||.|.  |. ||. ..| || .  .  |.|||.|...  .||||| |.|  | |||.|||     
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst..

VTYGSIQVSVQALQQYDHWVIREFSISQG--DEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAiqKTASDRPIVAHCSAG
  |  ..|...  . .  ..|| | .||    | | . ||||  |||.|||. . ..| . | . .        || | |||||
skycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkd..slpgarpwvihcsag

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 539-720 6e-32 105.4 In-house 34-211 (281) alignment
Range on Protein: 539-720
Range on HMM: 34-211/281.0
EMVNRAKNRFTNILPYEHSRVKLAA-LADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADY-N
. ||  |||..||   . |||.|   . .   |||| ||||      | ..  |||   |  |.|||||...|. |||| |..|  . || ||.| .   
qpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahc

PVTYGSIQVSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVReaiqktASDRPIVAHCSAGA
 . .  . || .        |   . .|   | | .|.. .  |||  ||| .  ||  .| .|      |   | | ||||| 
clqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkir......arstppvihcsagv

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 539-720 2.4e-27 90.5 In-house 45-230 (305) alignment
Range on Protein: 539-720
Range on HMM: 45-230/305.0
EMVNRAKNRFTNILPYEHSRVKLaalADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYNPV
|  .. |||. ..   .. ||||         .|| |||.     |. |. .| ||  |  |.| | ...|   | || .|.|||  ||.||.... ..|
eaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdv

TY-----GSIQVSVQALQQYD-----HWVIREFSI---SQGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVReaiqktASDRPIVAHCSAGA
         |.| ... ....     . ...|  .     | . || |.||.. ||| |||    ..|...   |      .|  ||| ||||| 
lefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekar......pskgpivvhcsagi

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 540-720 1.8e-58 193.3 In-house 59-235 (319) alignment
Range on Protein: 540-720
Range on HMM: 59-235/319.0
MVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTqlvekgKIKCHEYWPADYNpVT
  |. |||..|||......|||  |     .||||| .. || ..  ..|.||||. |..|.|||||| ..| ||.||      | || .||| . . ..
dqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv.ik

YGSIQVSVQALQQYDHWVIREFSISQ---GDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQKTASDRPIVAHCSAGA
..  .|.|..... . .|.|.. .|.     .|||.||.||. |||.|||. .  .. .|. ||   .|    ..|| |||||.
eerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGv

subfamily_ptpA1_pd Subfamily ptpA1 540-722 2.4e-40 133.5 In-house 45-242 (418) alignment
Range on Protein: 540-722
Range on HMM: 45-242/418.0
MVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGyNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYNP--
  | .|||.||||| .|.||.|  . |   .|||||||| |   |..|.. ||||| |. |.|||.||..  |||||..  |. .|||  ||| .     
khntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeq

--------VTYGSIQVS-VQALQQYDHWV-IREFSISQGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTV--REAIQKTASDR--PIVAHCSAGAIK
          .|.  |  |. .|. .. .  |.  ..   | | .|||..  |||| .|..|  . ......  |.     .|||  ||. |||||  .
fsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgr

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 540-720 6.2e-27 89.0 In-house 53-232 (305) alignment
Range on Protein: 540-720
Range on HMM: 53-232/305.0
MVNRAKNRFTNILPYEHSRVKLAalaDDSDTDYINANYIPGYNSP-REFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADY---
 .. .|||....   ..| |||.   . | .||| |||.     | . |...||||  |.|..| |. ..|   |||| . || ||.|| .||||     
diaitknryqdvpcqdqsavkld...kpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgek

NPVTYGSIQVSVQ---ALQQYDHWVIREFSISQ-GDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVReaiqktASDRPIVAHCSAGA
  .  | .   |     ...     |  . ..  ||.   . . ..  ||| |||    | |... ..|       |  ||| ||||| 
lelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair......gskvpivvhcsagi

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 540-687 3.3e-10 33.1 In-house 25-156 (169) alignment
Range on Protein: 540-687
Range on HMM: 25-156/169.0
MVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINAnyipgynsprefmacqgplpgtvddmwRMIWEKKTSIIVMLTQLVEKGKIKCH----EYWPADY
 .| .||| .  |   | ||||  . .|  .|||||                           |||||  .|.||.| .  .|  .       .  ||  
tcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddknnfwpekedyqlhpavi

NPVTY-GSIQVSVQALQQYDHWVIREFSI-----SQGDEIR-KLTQYHFMSWPDHGVPE
    |  |. |  . ...  . |   | .     |  |..  ||. .|. .||. |||.
lgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpq

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 540-623 1.6e-09 30.8 In-house 24-80 (169) alignment
Range on Protein: 540-623
Range on HMM: 24-80/169.0
MVNRAKNRFTNILPYEHSRVKLAALADDSDTDYINAnyipgynsprefmacqgplpgtvddmwRMIWEKKTSIIVMLTQLVEKG
 .| .||| .  |   | ||||  . .|  .|||||                           |||||  .|.||.| .  .| 
tcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddkn

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 541-720 1.2e-57 190.5 In-house 24-199 (284) alignment
Range on Protein: 541-720
Range on HMM: 24-199/284.0
VNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTqlvekgKIKCHEYWPADYNpVTY
 |. |||...||......|||  |     .||||| .| || ..  ..|.||||. |..|.|||||| ..| ||.||      | || .||| . . ...
qnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv.ike

GSIQVSVQALQQYDHWVIREFSISQ---GDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQKTASDRPIVAHCSAGA
.  .|.|..... . .|.|.. .|.     .|||..|.||. |||.|||. .  .. .|. ||   .|    ..|| |||||.
erfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagv

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 541-719 6.7e-52 171.1 In-house 19-207 (270) alignment
Range on Protein: 541-719
Range on HMM: 19-207/270.0
VNRAKNRFTNILPYEHSRVKLAALADDSDTDYINANYIPGYN-SPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYNP--
 ... ||...|||  ..||.|. | .|| | ||||||..|.. ......| .|||| |. . ||||||.|.. |||.|.|.|||. ||  ||||. .   
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekv

-VTYGSIQVSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPEKTW------TMLDFVRTVREAIQKTASDRPIVAHCSAG
 ...| |.| ... .. . .....  . .  |.|.|. ... .|||||||...        .|  .|.||.  ....   |.. |||||
kledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaG

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 541-720 1.4e-26 88.2 In-house 42-215 (288) alignment
Range on Protein: 541-720
Range on HMM: 42-215/288.0
VNRAKNRFTNILPYEHSRVKLAalaDDSDTdYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYNPVT-
 | ...|..|.   . .||||    ||.|  ||.|| ..  . .| .. .| || ||.. .|.|. |.    ||||..|.|||| |  ||.|      . 
anptrdryenlprcditrvkls...ddpdf.yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

YGSIQVSVQ-ALQQYDHW-VIREFSISQGDEIRK-LTQYHFMSWPDHGVPEKTWTMLDFVRTVreaiqkTASDRPIVAHCSAGA
.| .   |.   .. |.  ..  . ||.  | .. . . |.  |.|.||||.  . | ..  .       . ..||| |.|||.
igrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl......kslqkPivvhssaGv

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 541-732 1.1e-18 62.2 In-house 34-226 (285) alignment
Range on Protein: 541-732
Range on HMM: 34-226/285.0
VNRAKNRFTNILPYEHSRVKLaalaDDSDTDYINANYI--PGYNSpREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYNP-
 |   ||....   | .|| |     . | ||| |...  || .    ... ||||| |. |.|.||...| . ..||  |.| |  ||  |.|      
anpdlnryadvrcieetrvvl....knhdrdyihaswmrmpgkdq.styittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev

VTYGSIQVSVQALQQY--DHWVIREFSISQGDEIRK----LTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQKtasDRPIVAHCSAGAIKCHEYWPADY
| .|  ....   ..      ..  ... . ..       . . .   |||.  || .  |... . |..   |   ..||. |||||  .   .   ||
vkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk...ekpicvhcsagvgrtatfvgidy

N
 
a

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 541-717 1.4e-17 58.2 In-house 46-219 (303) alignment
Range on Protein: 541-717
Range on HMM: 46-219/303.0
VNRAKNRFTNILPYEHSRVKLaaladdSDTDYINANYIPgYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYNPVTY
 |  ||||....  .||.|||      ||. || |.|.   .| .  .  | ||. |  |.|.|| |.|   ...|    |  |.  .  .| . . . .
knmdknrfvdvicldhskvkl......sdssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

GSIQVSVQALQQ---YDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPEK-TWTMLDFVRTVREAIQKTASDRPIVAHCS
    . |  ...    | ||..  |.|.||    |  .|. .||   .| . .  ..  .  ..  ..| .  .| |    
eersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymsl

Y_phosphatase Protein-tyrosine phosphatase 542-720 6.3e-58 191.3 Pfam-A 1-181 (235) alignment
Range on Protein: 542-720
Range on HMM: 1-181/235.0
NRAKNRFTNILPYEHSRVKLaalADDSD-TDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWP-ADYNPVT
|. |||...||||...||||    .... .|||||||. ||.....|.|.||||. |..| |||.|..|...|||||.|.|||. ||..||| .. ...|
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGSIQVSVQ-ALQ-QYDHWVIREFSISQGDEI---RKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIqkTASDRPIVAHCSAGA
||.|.| ..   . . .....|...... .|    |...|.|. .||||||||..  .||..| |..    .|.. |.| |||||.
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGv

Y_phosphatase Protein-tyrosine phosphatase 542-720 6.3e-58 191.3 In-house 1-181 (235) alignment
Range on Protein: 542-720
Range on HMM: 1-181/235.0
NRAKNRFTNILPYEHSRVKLaalADDSD-TDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWP-ADYNPVT
|. |||...||||...||||    .... .|||||||. ||.....|.|.||||. |..| |||.|..|...|||||.|.|||. ||..||| .. ...|
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGSIQVSVQ-ALQ-QYDHWVIREFSISQGDEI---RKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIqkTASDRPIVAHCSAGA
||.|.| ..   . . .....|...... .|    |...|.|. .||||||||..  .||..| |..    .|.. |.| |||||.
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGv

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 542-719 4.4e-54 178.4 In-house 28-211 (274) alignment
Range on Protein: 542-719
Range on HMM: 28-211/274.0
NRAKNRFTNILPYEHSRVKL-AALADDSDTDYINANYIPGYNS-PREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYNP--
.  |||...||| |.||| | .. ..|.|..||||||| ||.   . ..| ||||| ||.|.||||.......|||||.| |. . ||..|.| . .   
sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyei

-VTYGSIQVSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQKTASD-RPIVAHCSAG
  .|| ... |.   . ... .|......  . |... | . .|||| .|... |.||.|. |.|. ....    |.| |||||
serygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaG

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 542-719 3.8e-50 165.3 In-house 3-182 (237) alignment
Range on Protein: 542-719
Range on HMM: 3-182/237.0
NRAKNRFTNILPYEHSRVKLAALAddSDTDYINANYIPGYN-SPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYNPVTY
|..|||. ||  |.|||| |      |..|||||.|. |.. .|....|.||||  . ||.|.|.|..| |.||||| |.|. ..|||.|||   .| .|
nkiknrygnivaydhsrvvlkgag..sgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GSIQVSVQALQQYDHWVIREFSISQ---GDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQKTASDRPIVAHCSAG
| . ||..  ...  . .| . .|.     |.| . ||.| ||||.|||..| ..| | . . .  .. .   | . |||||
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsag

0041856 (Phosphotyrosine protein) phosphatases II 542-719 3.1e-36 120.0 In-house 1-119 (182) alignment
Range on Protein: 542-719
Range on HMM: 1-119/182.0
NRAKNRFTNILPYEHSRvklaaladdsDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTqlvekgkikCHEYWPadynpvtyg
|. |||...||||.|||          | ||||||.. |.  ...| |.||||..|| |..||..| . ..||.||         .. |||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

siqvsvqalqqydhwvirefsisqGDEIRKLTQYHFMSWPDHGVPEkTWTMLDFVRTVREaiqktaSDRPIVAHCSAG
                         .. |  .||....|||||||. . ..|||...|.|      ...|.. |||||
........................ellerlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaG

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 542-720 3.2e-22 73.5 In-house 52-234 (310) alignment
Range on Protein: 542-720
Range on HMM: 52-234/310.0
NRAKNRFTNILPYEHSRVKLAaLADDSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYNPVTYG
.  |||.....  . |||||  .      ||| |||.        |. .||||  |. |.||||.....  |..| . .|.|. ||  |||.     |||
ymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetyg

SIQVSVQAlQQYDHWVIREFSIS----------QGDEIRKL--TQYHFMSWPDHGVPEKTwtmldfVRTVREAIQKTASDRPIVAHCSAGA
 |.|.  . .  . . | .....          |  ....|  .  ..  ||| |||..       . || . .       | | ||||| 
cirvtnls.esseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdek......chtvpqrllaqvrhgpcvvhcsagk

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 542-627 4.3e-10 33.6 In-house 34-118 (332) alignment
Range on Protein: 542-627
Range on HMM: 34-118/332.0
NRAKNRFTNILPYEHSRVKLAAlaDDSDTDYINANYIPGYNSPREFMACQGPLPGTVDD-MWRMIWEKKTSIIVMLTQLVEKGKIKC
|   ||   .  ..||||.||   .|   |. ||... ||.    .. .| |.    .  .|||. |.| |.|... .. || | |.
nmdmnriphlycfdhsrvelap..qdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 544-719 9.2e-33 108.1 In-house 58-226 (290) alignment
Range on Protein: 544-719
Range on HMM: 58-226/290.0
AKNRFTNILPYEHSRVklaALADDSDTDYINANYIPGYNSPreFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADY-NPVTYGS
 |||. ..   . .||    | |  | ||. |||. | ...  |.  ||.|  || |.|||. ..|.. |||| .|.|.|| ||..|.|    . .|.|.
kknrykdvvcndktrv...ilkdGydGdyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGe

IQVSVQALQQYDHWV-IREFSISQGDE--IRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAiqktasDRPIVAHCSAG
| |     .. |  .  . .|. . |.    ||  .. .||||. |.  | ..|  .|..|.|        |.| |||||
itvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka......sGpvvvhcsaG

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 545-719 7.1e-12 40.1 In-house 22-201 (290) alignment
Range on Protein: 545-719
Range on HMM: 22-201/290.0
KNRFTNILpYEHSRVKLAALADDSDTDYINANYIPgYNSPREFMACQGPLPG-------TVDDMWRMIWEKKTSIIVMLTQLVEKGKI----KCHEYWPA
..| .. |  |..|| |         ||| ||..  . .  .... | |.         |. . | |. . |   .||| .  || .      | .| | 
dqRlevpL.veatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpe

DYN-PVTYGSIQVSVQALQQYDHWVIREFSISQGDEIR-KLTQYHFMSWPDHGVPEKTWTMLDFVRTVReaiqktASDRPIVAHCSAG
  .  .... ..|. .   . |   .||  .  .||   ..| . . .| .  |.|.| |.|. ...|.      ||. |.. ||  |
svgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk......asktpvivHcvdG

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 552-685 5.3e-11 36.9 In-house 3-126 (130) alignment
Range on Protein: 552-685
Range on HMM: 3-126/130.0
LPYEHSRVKlaaladdsDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKgkikcHEYWPaDYNPVTYGSIQVSVQALQ
|..| ||..        . .||||...   .  .|..  | ||  |  |.|.|. |.   ..|.|  . |.      |||| | .|. .   .. |   .
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywp.dsePlewyeediivtltd

QYDHWVIREFSISQGDEIRK----LTQYHFMSWPDHGV
. .   |.   .   ... .    || ..   ||  | 
rdefknikasnleiesdlneshqaltmfqisnwpsdgt

0044763 (Phosphotyrosine protein) phosphatases II 553-719 9.6e-24 79.4 In-house 1-120 (178) alignment
Range on Protein: 553-719
Range on HMM: 1-120/178.0
PYEHSRVKLAALADDSDTDYINANYIPGYnsprEFMACQGPlpgtvDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYNpvtygsiqvsvqalqq
|....||.|  | .   .|||||..| ..     ......|      | .....| . . ||.||. .| |..||..||| ...                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

ydhwvirefsisqgdeirklTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQktASDRPIVAHCSAG
                     ||... .||||||. .. .|.||. ..||..   ...|.. |||||
....................iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaG

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 563-618 5.4e-09 30.0 In-house 64-118 (347) alignment
Range on Protein: 563-618
Range on HMM: 64-118/347.0
ALADDSDTdYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQ
. |||..| |||| .|   |. .|..  | ||| || |.|.|.   | . .| . .
sraddvet.yinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife

0046846 (Phosphotyrosine protein) phosphatases II 565-719 3.7e-28 93.9 In-house 7-119 (176) alignment
Range on Protein: 565-719
Range on HMM: 7-119/176.0
ADDSDTDYINANYIPGYnsprEFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYNPVTygsiqvsvqalqqydhwvirefsis
 .| | ||||||.| |.     . |.|||||.|. | ..|..| . ...|.||..||.|..||. |||  ...                           
gldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.........................

qgdeirkltQYHFMSWPDHGVPEKtWTMLDFVRTVREAIQKTasdRPIVAHCSAG
         ||... |||||||.    .|.... .|||...    .|.. |||||
.........qylhlpwpDhgvpdl.elllellefirealkeg...gpvlVHCsaG

0043147 (Phosphotyrosine protein) phosphatases II 567-719 4.3e-28 93.6 In-house 2-110 (172) alignment
Range on Protein: 567-719
Range on HMM: 2-110/172.0
DSDTDYINANYIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLvekgkikcheywpadynpvtygsiqvsvqalqqydhwvirefSISQG
|...|||||.|...|  |..| |.||||. |..| |||..|.. ..||.||.|                                               
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..........................................lydpe

DEIRKLTQYHFMSWPDHGVPeKTWTMLDFVRTVREAIqKTASDRPIVAHCSAG
.. |   ||....|||||||  .  .|.|.. ..|..    .. |.. |||||
llerlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaG

0051429 (Phosphotyrosine protein) phosphatases II 570-719 4.3e-35 117.0 In-house 4-160 (272) alignment
Range on Protein: 570-719
Range on HMM: 4-160/272.0
TDYINANYIPGYNS---PREFMACQGPLPGTVDDMWRMiWEKKTSIIVMLTQLVEKGKIKCHEYWP-----------ADYNPVTYGSIQVSVQALQQYDH
..||||....||..   |. . ...|||| |..| ||. .| . . ||.|....|.|. ||. |||            .. ...|| . | ..  .....
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

WVIREFSIS---QGDEIRKLTQYHFMSWPDHGVPEKTwtMLDFVRTVREaiqktasDRPIVAHCSAG
...||. ..   . .|.|.....|...|||||||...  .|.... ...       ..|.. |||||
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaG

0036282 (Phosphotyrosine protein) phosphatases II 570-719 7.8e-30 99.2 In-house 2-114 (174) alignment
Range on Protein: 570-719
Range on HMM: 2-114/174.0
TDYINANYIPGYNSPREFMACQGPLPgtvddMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPAdynpvtygsiqvsvqalqqydhwvirefsiSQGDEI
.|||||... ..  .... |.||||.      |.|..| . ...|||....|.|. ||. |||                                . |. 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredle

RKLTQYHFMSWPDHGVPEKTWtMLDFVRTVREAIQKtASDRPIVAHCSAG
|   ||... |||||||. .  .|.||. |.||...  ...|.. |||||
rlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaG

0051082 (Phosphotyrosine protein) phosphatases II 570-720 3.7e-21 70.7 In-house 3-103 (151) alignment
Range on Protein: 570-720
Range on HMM: 3-103/151.0
TDYINANYIPGYnspreFMACQGPLPgtvdDMWRMIWEKKTSIIVMLTQLVEKGkiKCHEYWPADYnpvtygsiqvsvqalqqydhwvirefsisqgdei
.||||..|. |.     . ...|||.    | .....| . . ||.|....| |  .|.||.|.                                    
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

RKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREaiqktASDRPIVAHCSAGA
..........|||.|.|. . ..|.|.. ...      .. |.. ||||| 
ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGk

0049260 (Phosphotyrosine protein) phosphatases II 577-719 1.7e-26 88.2 In-house 1-99 (152) alignment
Range on Protein: 577-719
Range on HMM: 1-99/152.0
YIPGYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWpadynpvtygsiqvsvqalqqydhwvirefsisqgdeirkltQYH
.|.||. |.||.|.|||.| |..| |||..| . ..|||||.|.|.||.||..|.                                          ||.
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qyl

FMSWPDHGVPEKTWTMLDFVRTVREAiqKTASDRPIVAHCSAG
.. |||||||. .  .|.... ....  .  .. |.. |||||
hlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaG

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 580-648 4.3e-11 36.8 In-house 231-296 (440) alignment
Range on Protein: 580-648
Range on HMM: 231-296/440.0
GYNSPREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKgkiKCHEYWPADYNPVTYGSIQVSVQ
||     |.| | ||  || |.||.. . . | |.|| || .|    |  ||| .   ||.| . |  .
gyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvghk

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 584-719 1.2e-13 45.7 In-house 4-145 (199) alignment
Range on Protein: 584-719
Range on HMM: 4-145/199.0
PREFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADY-NPVTYGSIQVSVQALQQYDHWVIREFSI----SQGDEIRKLTQYHFM
 | ..|.| ||  |. |.|.|.||  .  |||. .   . .     |||.       |||. |.....     ..|  . .    .     |....| | 
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWPDHGVPEKTwTMLDFVRTVREAIQKT--ASDRPIVAHCSAG
|| ..  |. .  .. || . ||  .|     | |.. ||| |
swkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdg

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 585-719 1.2e-13 45.7 In-house 4-144 (198) alignment
Range on Protein: 585-719
Range on HMM: 4-144/198.0
REFMACQGPLPGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADY-NPVTYGSIQVSVQALQQYDHWVIREFSI----SQGDEIRKLTQYHFMS
| ..|.| ||  |. |.|.|.||  .  |||. .   . .     |||.       |||. |.....     ..|  . .    .     |....| | |
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPEKTwTMLDFVRTVREAIQKT--ASDRPIVAHCSAG
| ..  |. .  .. || . ||  .|     | |.. ||| |
wkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdg

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 595-720 7.7e-09 29.4 In-house 101-232 (302) alignment
Range on Protein: 595-720
Range on HMM: 101-232/302.0
PGTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYNP-VTYGSIQV---SVQ-ALQQY-DHW--VIR--EFSISQGDEIRK--LTQYHFMSWPD
  |..  | .| . ...|.| |...||... || ||.  . .  ...|   |   ||.  |... |    ..   |.  ..  .  |  .   .| .|||
kstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpd

HGVPEKTWTMLDFVRTVrEAIQKTasdrpIVAHCSAGA
|| |... | || ..   |. .|.     .. ||||| 
hGapkeaytaldilkfc.esykkn.....vlvhcsaGv

subfamily_hpo-7_pd Subfamily hpo-7 596-720 8.1e-12 39.6 In-house 45-165 (263) alignment
Range on Protein: 596-720
Range on HMM: 45-165/263.0
GTVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYNP-VTYGSIQVSVQALQQydHWVIREFSISQ--G--DEIRKLTQYHFMSWPDHGVPEKTW
 |.| ....|  .||. .|||.   |.|. || .|.| . .    .  ..|..   |.    ...   . .  |   .......| .  |...  ||.. 
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelar

TMLDFVRTVREaiqktaSdRPIVAHCSAGA
 .|  .. .|.      | ...|.|||.| 
eilnilkvarn......s.kslvvhcstGi

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 597-720 1.1e-12 42.6 In-house 40-159 (255) alignment
Range on Protein: 597-720
Range on HMM: 40-159/255.0
TVDDMWRMIWEKKTSIIVMLTQLVEKGKIKCHEYWPADYNPVTyGSIQVSVQALQQYDHWVIREFSISQ----GDEIRKLTQYHFMSWPDHGVPEKTWTM
||| ....|  .||. .|||. . |.|. ||..|.| . .       .|.| . .   . |.|   |        . .... |..  |...  || .  .
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdekl.kladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelarei

LDFVRTVREaiqktaSdRPIVAHCSAGA
|  .. ||.      | ...| |||.| 
lnilkvvrd......s.ksvvvhCstGi

0048076 (Phosphotyrosine protein) phosphatases II 645-719 1.1e-12 43.4 In-house 20-91 (145) alignment
Range on Protein: 645-719
Range on HMM: 20-91/145.0
VSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQKtasDRPIVAHCSAG
.... |...... .  ..  . .. |. .||....|||||||. . ..|.|.. ..||...   ..|.. |||||
ldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke...ggpvlVHCsaG

0048179 (Phosphotyrosine protein) phosphatases II 646-719 4e-11 38.3 In-house 21-93 (144) alignment
Range on Protein: 646-719
Range on HMM: 21-93/144.0
SVQALQQYDHWVIREFSISQGDEIRKLT--QYHFMSWPDHGVPEKTWTMLDFVRTVREAIQktaSDRPIVAHCSAG
... |...... .  .. .   |  . .  ||....|||||||. .  .|.|.. ..||..   ...|.. |||||
dlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaG

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 663-722 2.1e-09 31.2 In-house 82-140 (440) alignment
Range on Protein: 663-722
Range on HMM: 82-140/440.0
ISQGDEIRKLTQYHFMSWPDHGVPEKTWTMLDFVRTVREAiQKTASDRPIVAHCSAGAIK
  .| | | | |||. .|||.|||. .  .| ... | |. |. |.. |.. |||||| .
yingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnes.qekagngpllvhcsagagr

PTPc_DSPc_SM00012 672-720 2.6e-12 42.2 In-house 2-50 (105) alignment
Range on Protein: 672-720
Range on HMM: 2-50/105.0
LTQYHFMSWPDHGVPEKTWTMLDFVRTVREAIQKTASDRPIVAHCSAGA
...||...||||||||..  .|...| |..  .| .|  |.| |||||.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGv

subfamily_CG42327_pd Subfamily CG42327 694-799 4.7e-09 30.3 In-house 87-194 (319) alignment
Range on Protein: 694-799
Range on HMM: 87-194/319.0
DFVRTVREaiQKtasDRPIVAHCS---AGAIKCHEYWPAD---YNPVTYGSIQVSVQALQQYDHWVIREFSIS--QGDEIRKLTQYHFmSWPDHGVPDKT
|| ||| |  |.    | ||  ..    |  .| ||.|.     |  .|| |.|...  .  |...|  . .   ...| |.|| | .  |.. .|| . 
dfwrtvwe..qq...srvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaee

WTMLDFVRTVREAI
 ...  .  ||...
aaliamllevrssl

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 717-884 9.2e-16 52.3 In-house 130-300 (310) alignment
Range on Protein: 717-884
Range on HMM: 130-300/310.0
SAGAIKCHEYWPADYNPVTYGSIQVSVQAlQQYDHWVIREFSIS----------QGDEIRKL--TQYHFMSWPDHGVPDKTwtmldfVRTVREAIQKTAS
  |  ||  |||.     ||| |.|.  . .  . . | .....          |  ....|  .  ..  ||| ||||.       . || . .     
eegrpkcvgywpslgvtetygcirvtnls.esseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdek......chtvpqrllaqvr

DRPIVAHCSAGVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMdLLRRGEEeDTGESI
  | | |||||..|... .||.  .. ... ...|.  .. |.. .|   .||| ||..|.   . .. |||. .. |.|
hgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri.ifarget.evaeki

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 718-786 3.5e-08 27.6 In-house 113-184 (297) alignment
Range on Protein: 718-786
Range on HMM: 113-184/297.0
AGAIKCHEYWPA-DYNPVTYGSIQVS--VQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPDKTW
 |  ||  |||  . .  . |.. |    .  ...|. .. |. .   .| |...   |.||||||||    
dGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdle

subfamily_PTPRB_pd Subfamily PTPRB 719-879 9.3e-86 282.5 In-house 132-292 (293) alignment
Range on Protein: 719-879
Range on HMM: 132-292/293.0
GAIKCHEYWPADYNPVTYGSIQVSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTASDRPIVAHCSAGVGR
| .||.||||||..||.||.|.|...| .....|||||..|....|.||..||||.||||||||.||.|.|||||||||||.||||.||||.||||||||
gkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGR

TGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRRGEEED
|||.||||||.||..|.||.|||||..|.|..||..|||||||||||.||.||||..|||.
tGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkkeeek

0050432 (Phosphotyrosine protein) phosphatases II 719-874 7.8e-51 168.6 In-house 146-301 (308) alignment
Range on Protein: 719-874
Range on HMM: 146-301/308.0
GAIKCHEYWPAD--YNPVTYGSIQVSVQALQQYDHWVIREFSISQ--GDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIqktaSDRPIVAHCSA
| .||..||| .   ....|| ..| .   ...|....|.. ..   ..| |..|..|...|||||||...  .|||.. ||. .    .. ||| ||||
grekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl....pggpivVHCsa

GVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRR
|||||||.|||| |.. ....  .|.|.... .|.||..||||. ||.|........|..
GvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl

0051299 (Phosphotyrosine protein) phosphatases II 719-872 1.7e-50 167.4 In-house 130-286 (288) alignment
Range on Protein: 719-872
Range on HMM: 130-286/288.0
GAIKCHEYWPAdYNPVTYGSIQVSVQALQQYDHWVIREFSIS------QGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQktASDRPIVAHC
| .||. |||   ...||| |.|     ...|....|.. ..      ...| |. |..|...|||||||| .  .|||.| ||.|..  ... |.| ||
grekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala..sgggpvvVHC

SAGVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLL
|||||||||.|||| |.. ....  .|...... .|.||..||||. ||.|..|.....|
saGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 719-874 2.4e-50 166.2 In-house 122-278 (281) alignment
Range on Protein: 719-874
Range on HMM: 122-278/281.0
GAIKCHEYWPADYNPVTYGSIQVSVQALQQYDHWVIREFSI-SQGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAiQKTASDRPIVAHCSAGVG
| .||| ||| | . ..|| ..|. .| ..  ... |.|..  .. | |...| ....|||||||..|  .|.| . |... ... .. |.| |||||||
gklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkl.tekktkaplvihCsaGvG

RTGTYIALDRLMQAM-QENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRR
|||||||||||..|. .|.  .|.  .. |.| .|| ||||  || |..  |.| | .
rtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk

0047943 (Phosphotyrosine protein) phosphatases II 719-871 5.4e-49 162.5 In-house 115-271 (273) alignment
Range on Protein: 719-871
Range on HMM: 115-271/273.0
GAIKCHEYWPADYN--PVTYGSIQVSVQALQQYDHWVIREFSISQ--GDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTASDRPIVAHCSA
| .||. ||| . .  ..||| ..| .   ...|....|.. ..    .| |. |..|...|||||||. .  .|.|.. ||.|.... |. |.| ||||
grekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsa

GVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDL
|||||||.|||| |.. ....  .|.. ... .|.|| .||||. ||.|..|.....
GvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley

0036941 (Phosphotyrosine protein) phosphatases II 719-875 8.3e-49 161.8 In-house 116-280 (297) alignment
Range on Protein: 719-875
Range on HMM: 116-280/297.0
GAIKCHEYWPAD-YNPVTYGSIQVSVQALQQ--YDHWVIREFSISQ--GDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTASDRPIVAHCS
| .||..||| .  ...||| ..| ..  ..  .|....|.. ..   ..| |..|..|...|||||||. . ..|||.. ||...... |. |.. |||
grekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCs

AGVGRTGTYIALDRLMQAMQ---ENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRRG
|||||.||.||.| ..| ..   ..  .||. .....|.||...|||. ||.|..|....||...
aGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk

0037934 (Phosphotyrosine protein) phosphatases II 719-871 4.1e-44 146.3 In-house 86-241 (243) alignment
Range on Protein: 719-871
Range on HMM: 86-241/243.0
GAIKCHEYWPadyNPVTYGSIQVSVQALQQYDHWVIREFSISQ---GDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQK------TASDRPIV
|..||..|||   ..|||| ..| .   ...|....|.....    .|. |  ..||...|||||||| .  .|||.. ||| |..        |..|..
grekcaqywp...gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvl

AHCSAGVGRTGTYIALDRLMQAMqenDyIDIFGIICEMRMQRNH-MVQTEKQYIFIHECVMDL
 |||||||||||.||.. ... .   . .|.. .....|.||.. .|||. ||.|..|... |
VHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel

subfamily_PTPN3_pd Subfamily PTPN3 719-871 4.4e-43 142.2 In-house 122-274 (280) alignment
Range on Protein: 719-871
Range on HMM: 122-274/280.0
GAIKCHEYWPADYNPVTYGSIQVSVQALQQYDHWVIREFSISQGD--EIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAiqKTASDRPIVAHCSAGV
| .|||.|||   . ..||...| ..  ..   .|.||. ... .  | ||..|  ...||||||||..  .|.||..||..  ......|.| |||||.
GrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrkl..rsgkeePvvvhCsaGi

GRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDL
|||| .|.|.  .. ..... . .  |. .|| ||  .|||..|| |. |... .
grtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv

subfamily_PTPN13_pd Subfamily PTPN13 719-873 9.2e-41 134.9 In-house 115-270 (273) alignment
Range on Protein: 719-873
Range on HMM: 115-270/273.0
GAIKCHEYWPADYN-PVTY-GSIQVSVQALQQYDHWVIREFSIS--QGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREaIQKtaSDRPIVAHCSA
| .||| |||   | ...  . ..|..  .|..| .|.|.. ..  .  | |.... .|..||||||| ..  .| ||. ||. .|.  .  ||| ||||
gkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrr.lqt..dagPivvhcsa

GVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLR
|.||.||.|..| ... .. .  .|.  |. ..| ||. .|||..||||... ....|.
GiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk

subfamily_PTPN9_pd Subfamily PTPN9 719-871 1.8e-38 127.3 In-house 123-289 (297) alignment
Range on Protein: 719-871
Range on HMM: 123-289/297.0
GAIKCHEYWPA-DYNPVTYGSIQVSVQALQQYDHWVIREFSIS--QGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQ-----------KTAS
| .|| .|||  . .   .|...||.   ........| . |.  . .|.||.| . |.||||.|||. . ..||....|||.               .|
grlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghps

DRPIVAHCSAGVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDL
. ||| |||||.|||||.|.||  .. ..| . .|..  .  .| || ...||..|| | . .|.. 
gPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 719-874 1.4e-34 114.3 In-house 129-285 (290) alignment
Range on Protein: 719-874
Range on HMM: 129-285/290.0
GAIKCHEYWPADYNPVtYGSIQVSVQALQQYDHWVIREFSISQGDE---IRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREaIQKTASDRPIVAHCSAG
|  ||. |||.  .   || ... ..  ..... ..|.... . ..    ...|||.. .|...|   .. |.|  .. . . .|.   ...|| |||..
gkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyk.tqrkrgntsivvHCSdt

VGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRR
|||.....|..  .. .. .  ||.| .. ..|.|.  .|||..|| .|.. |.  | .
vgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds

subfamily_PTPN14_pd Subfamily PTPN14 719-874 1.7e-29 97.8 In-house 131-298 (300) alignment
Range on Protein: 719-874
Range on HMM: 131-298/300.0
GAIKCHEYWPAD---YNPVTYGSIQVSVQALQQYDHWVIREFSISQ--GDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTASDR-------
|  |...|.| .    . |..|  .|. .  .. |  . . . .      | |..    .. |||||||.   ..|.... |.   .|| | .       
gkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskP

PIVAHCSAGVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRR
|.. ||||||||||  |  | |..... |. |||  ..  .| || ..|||  || |... ..  |..
PvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkn

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 719-871 7.5e-25 82.6 In-house 120-276 (307) alignment
Range on Protein: 719-871
Range on HMM: 120-276/307.0
GAIKCHEYWPADY-NPVTYGSIQ--VSVQ-----ALQQYDHW-VIREFSISQGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREaiqktaSDRPIV
. |||..|||..  .  ..|.    .||.      |   ..   . .. .  ... | .... .  |||.|||.   | .... .||          |.|
akikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry......dtnpvv

AHCSAGVGRTGTYIALDRLMQAM-QENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDL
 ||||||||.|| .|.  ... | .  .  |.  .. |.| ||.. .||| ||...|  ... 
vhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 719-871 3.1e-23 76.9 In-house 132-282 (290) alignment
Range on Protein: 719-871
Range on HMM: 132-282/290.0
GAIKCHEYWPADY-NPVTYGSIQVSVQALQQYDHWV-IREFSISQGDE--IRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAiqktasDRPIVAHCSA
|  ||..|.|    . .|.|.| |     .. |  .  . .|. . |.    ||  .. .||||. |.  | ..|  .|..|.|        |.| ||||
GkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka......sGpvvvhcsa

GVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDL
|.|||||..|..  .| . .   .|. ...  .|  |   || . ||. . | ..||
GiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 719-870 7.6e-20 65.7 In-house 134-287 (305) alignment
Range on Protein: 719-870
Range on HMM: 134-287/305.0
GAIKCHEYWPADY---NPVTYGSIQVSVQ---ALQQYDHWVIREFSISQ-GDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVReaiqktASDRPIVAH
| .|| .||||       .  | .   |     ...     |  . ..  ||.   . . ..  ||| |||    | |... ..|       |  ||| |
gklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair......gskvpivvh

CSAGVGRTGTYIALDRLMQAMQENDYID-IFGIICEMRMQRNHMVQTEKQYIFIHECVMD
||||.||||| .|.. ... . ||     .  ..  .| || . .|.. ||.|||  ...
csagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 719-880 3e-10 34.6 In-house 66-230 (255) alignment
Range on Protein: 719-880
Range on HMM: 66-230/255.0
GAIKCHEYWPADYNPVTyGSIQVSVQALQQYDHWVIREFSIS----QGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREaiqktaSdRPIVAHCSA
|  ||..|.| . .       .|.| . .   . |.|   |     .  . .... |..  |...  |. .  .|  .. ||.      | ...| |||.
gvekcssyfplekdekl.kladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareilnilkvvrd......s.ksvvvhCst

GVGRTGTYIALDRLMQ----AMQEN--DYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLL-RRGEEEDT
|.||. ...  . . |    ....     .|   .. |.| .|.  ..|  |  |    |.||.  .|| |. 
GiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfpkgeleak

subfamily_hpo-7_pd Subfamily hpo-7 719-879 1.7e-09 32.0 In-house 72-234 (263) alignment
Range on Protein: 719-879
Range on HMM: 72-234/263.0
GAIKCHEYWPADYNP-VTYGSIQVSVQALQQydHWVIREFSISQ--G--DEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREaiqktaSdRPIVAHCS
|  || .|.| . .    .  ..|..   |.    ...   . .  |   .......| .  |...  | ..  .|  .. .|.      | ...|.|||
gvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelareilnilkvarn......s.kslvvhcs

AGVGRTGTYIALDRLMQ----AMQEN--DYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRRGEEED
.|.||.  .   . . |    ....     .|   .. |.| .|.  ..|  |  |    |.|..     ..
tGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakg

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 720-879 3.9e-52 172.3 In-house 128-287 (318) alignment
Range on Protein: 720-879
Range on HMM: 128-287/318.0
AIKCHEYWPADyNPVTYGSIQVSVQALQQYDHWVIREFSISQ--GDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAiQKTASDRPIVAHCSAGVG
 .|.| ||| . .. .||...| ..   .....|.|||....   .| |.  |||. ||||.|||... ..||.||.|..| |.... .||| |||||||
kakvhryWPsk.gsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvska.qqksgagpivvhCsaGvG

RTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRRGEEED
|||..||.| |.. ....  .|.|... ..| ||| |||||.||.||.. ... |  |. | 
rtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtev

0046845 (Phosphotyrosine protein) phosphatases II 720-874 8.8e-52 171.6 In-house 116-276 (284) alignment
Range on Protein: 720-874
Range on HMM: 116-276/284.0
AIKCHEYWPADYNPVTYGSIQVSVQALQQYDHWVIREFSISQ---GDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTASDRPIVAHCSAGV
 .||. ||| . ...||| ..| .   ...|....|.....    ..| |..|..|..||||||||. .  .|.|.|.|||..... .. ||| ||||||
rekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGv

GRTGTYIALDRLMQAMQEND---YIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRR
|||||.|||| |.. .....    .|...... .|.||..||||. ||.|..|.....|..
gRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 720-878 1.2e-50 167.4 In-house 130-289 (319) alignment
Range on Protein: 720-878
Range on HMM: 130-289/319.0
AIKCHEYWPADyNPVTYGSIQVSVQALQQYDHWVIREFSISQ-GDEI--RKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTaSDRPIVAHCSAGV
 .|...|||   |...|| . | ..  .. ....||.... .  .|.  |.........||||.||.|. ..||... .|.. .|| ...||| ||||||
kvklkkywpee.nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrekt.qsgPivvhCsaGv

GRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRRGEEE
|||||.|.||  .. ..|.  .|.| .. ..|.||| |||...||.||.| ... .  |. |
GRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdte

0039614 (Phosphotyrosine protein) phosphatases II 720-874 1.7e-49 164.3 In-house 140-291 (297) alignment
Range on Protein: 720-874
Range on HMM: 140-291/297.0
AiKCHEYWPADYNpvTYGSIQVSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTASDRPIVAHCSAGVGRT
  ||..||| . .  ||| ..| .   ...|....|..... ..| |..|......|||||||. . ..|.|.. ||||.... ...|.. |||||||||
r.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRt

GTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRR
||.||...... ....  .|.. ...|.|.||...|||. ||.|.......||.|
GtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr

0040438 (Phosphotyrosine protein) phosphatases II 720-879 1e-48 161.6 In-house 125-283 (317) alignment
Range on Protein: 720-879
Range on HMM: 125-283/317.0
AIKCHEYWPAdYNPVTYGSIQVSVQALQQYDHWVIREFSIS--QGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQktASDRPIVAHCSAGVG
 .||..|||   ...||| ..| ..  ........|.. ..  ...| |..|..|...|||||||. . ..|||.. ||||..   .. |.. |||||||
rekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvlVHCsaGvg

RTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRRGEEED
||||.||...... ....  .|.. ...|.|.||...|||. ||.|........|.|..   
RtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltle

0045450 (Phosphotyrosine protein) phosphatases II 720-873 6.3e-48 159.5 In-house 146-305 (307) alignment
Range on Protein: 720-873
Range on HMM: 146-305/307.0
AIKCHEYWPADYNPVTYGSIQVSVQALQQYDHWVIREFSIS---QGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTASDRPIVAHCSAGV
 .||..||| .  ..||| ..| .   ...|....| . ..   . .| |..|..|. .|||||||. . ..|||.. ||.|.... .. |.. ||||||
rekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGv

GRTGTYIALDRLMQAMQENDY---IDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLR
|||||.||.. ... ....     .|.. .....|.|| ..||.. ||.|..|....||.
gRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll

0043336 (Phosphotyrosine protein) phosphatases II 720-872 1.2e-47 158.1 In-house 127-277 (278) alignment
Range on Protein: 720-872
Range on HMM: 127-277/278.0
AIKCHEYWPadYNPVTYGSIQVSVQALQQYDHWVIREFSIS--QGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQktASDRPIVAHCSAGVG
 .||..|||   ...||| ..| ..  ...|....| . ..  . .| |. |.||...|||||||. . ..|||...||||..   |. |.. |||||||
rvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale..dsngpvlVHCsaGvg

RTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLL
||||.|||..|.. .. .  .|.. ...|.|.|| ..|||. ||.|..|.....|
RTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl

DSPc_SM00195 720-872 4.1e-46 152.8 In-house 108-262 (263) alignment
Range on Protein: 720-872
Range on HMM: 108-262/263.0
AIKCHEYWPADY-NPVTYGSIQVSVQALQQYD-HWVIREFSISQGD--EIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTasDRPIVAHCSAG
 .||..||| .  .. |.|.|.| ..  .... ....|...... .  | ||.|||.. .||||||||.|  .|...|.|..  ...  . ||| |||||
kekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVhCsaG

VGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLL
||||||....| ... ..|.. .||| |..|.|.|| .||||..||.||.|......
vgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 720-872 4.1e-46 152.8 In-house 108-262 (263) alignment
Range on Protein: 720-872
Range on HMM: 108-262/263.0
AIKCHEYWPADY-NPVTYGSIQVSVQALQQYD-HWVIREFSISQGD--EIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTasDRPIVAHCSAG
 .||..||| .  .. |.|.|.| ..  .... ....|...... .  | ||.|||.. .||||||||.|  .|...|.|..  ...  . ||| |||||
kekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVhCsaG

VGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLL
||||||....| ... ..|.. .||| |..|.|.|| .||||..||.||.|......
vgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

0045098 (Phosphotyrosine protein) phosphatases II 720-875 1.4e-45 151.2 In-house 103-275 (278) alignment
Range on Protein: 720-875
Range on HMM: 103-275/278.0
AIKCHEYWPaDYNPVTYGSIQVSVQALQQYDHWVIREFSIS------QGDEIRKLTQYHFMSWPDHGVPDKT--WTMLDFVRTVREAIQ-----------
 .||..||| . ...||| ..| ..  ...|....| . .       ...| |..|..|...|||||||. .  . .|.... .|||..           
rekcaqywp.eggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssll

KTASDRPIVAHCSAGVGRTGTYIALDRLMQAMqeNDYIDIFGIICEMRMQRNH-MVQTEKQYIFIHECVMDLLRRG
   |. |.. |||||||||||..|.. ... .  .. .|.. ...|.|.||.. .||.. ||.|..|....||.||
lldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg

0042113 (Phosphotyrosine protein) phosphatases II 720-872 1.5e-45 150.9 In-house 91-243 (245) alignment
Range on Protein: 720-872
Range on HMM: 91-243/245.0
AIKCHEYWPAdYNPVTYGSIQVSVQALQQYDHWVIREFSIS--QGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKtASDRPIVAHCSAGVG
 .||..|||   ...||| ..| .   ...|....|.....  . || |. ..||...|||||||| . ..|||.. ||.|...  |. |.. |||||||
rvkcaqywpl.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvg

RTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLL
||||.||...... ....  .... .. |.|.|| ..|||. ||.|..|....||
RtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell

0040439 (Phosphotyrosine protein) phosphatases II 720-873 7.3e-45 148.9 In-house 93-247 (249) alignment
Range on Protein: 720-873
Range on HMM: 93-247/249.0
AIKCHEYWPAdYNPVTYGSIQVSVQALQQYDHWVIREFSIS--QGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTASDRPIVAHCSAGVG
 .||..|||   ....|| ..| .   ...|....|.. ..  . .| |. ..... .|||||||. . ..|||.. ||.|.... .. |.. |||||||
rekcaqywpl.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvg

RTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLR
||||.||.. ... ....  .|.. .....|.||...||.. ||.|..|....||.
RtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll

subfamily_PTPRK_pd Subfamily PTPRK 720-871 1.5e-40 133.9 In-house 125-276 (314) alignment
Range on Protein: 720-871
Range on HMM: 125-276/314.0
AIKCHEYWPADYNPvtYGSIQVSVQALQQYDHWVIREFSISQ----GDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKtaSDRPIVAHCSAG
..|| .||| | .   || |.| .   .     |.| |....     .|||.. |..|..||||.|| .  ..|..|| | .  ..  .. .|| |||||
rvkClkyWPedtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..eaGrivvhCsaG

VGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDL
 |||||.||.| ... ..... .|.| .. ..| ..  ||.||.||.||.. ... 
aGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvilea

0051429 (Phosphotyrosine protein) phosphatases II 720-873 1.3e-37 125.3 In-house 60-226 (272) alignment
Range on Protein: 720-873
Range on HMM: 60-226/272.0
AIKCHEYWP-----------ADYNPVTYGSIQVSVQALQQYDHWVIREFSIS---QGDEIRKLTQYHFMSWPDHGVPDKTwtMLDFVRTVREaiqktasD
. ||. |||            .. ...|| . | ..  ........||. ..   . .|.|.....|...|||||||...  .|.... ...       .
rlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......g

RPIVAHCSAGVGRTGTYIALDRLMQAMQENDYID--------IFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLR
.|.. |||||..||||..||..|.. . ... .|        ..... |.| || ..|||| ||.|..|....|||
gpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellr

subfamily_PTPRN_pd Subfamily PTPRN 720-870 4.1e-30 99.5 In-house 139-290 (297) alignment
Range on Protein: 720-870
Range on HMM: 139-290/297.0
AIKCHEYWPADYNPVtYGSIQVSVQAL-QQYDHWVIREFSIS--QGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTASdrPIVAHCSAGV
  .|..||| . . | |.  .| . .     | ...| | .   | .| | .||.||.|||..||| .. ..|.| | |  . .  ..  ||| |||.|.
vkqckrywpdeGsev.yhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrsc..pivvhcsdGa

GRTGTYIALDRLMQAMQE-NDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMD
||||.||..| ... ..     |||   .  .| ||...|.|..|. |.  .| .
GrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae

subfamily_PTPN1_pd Subfamily PTPN1 720-870 2.5e-29 96.9 In-house 110-269 (290) alignment
Range on Protein: 720-870
Range on HMM: 110-269/290.0
AIKCHEYWPADYN--PVTYGSIQVSV--QALQQYDHWVIREFSISQ--GDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTASDRPIVAHCS
 |||..||| . .   ...  ....|   . ........| . . .   .| |.....|...||| |||.   ..|.|.  |||.   .    | | |||
qikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcs

AGVGRTGTYIALDRLMQAMQENDY---IDIFGIICEMRMQRNHMVQTEKQYIFIHECVMD
||.||.||.. .| ..  ....|    .||   ..|.| .|  ..|| .|  | .  ...
aGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile

subfamily_egg_pd Subfamily egg 720-873 1.3e-06 22.3 In-house 120-271 (307) alignment
Range on Protein: 720-873
Range on HMM: 120-271/307.0
AIKCHEYWP-ADYNPVTY--GSIQVSVQALQQYDH--WVIREFSISQGDEIRKLTQyHFmSWpDHGVPDKTWTMLDFVRTVREAiqktasDRPIVAHCSA
. .|. ||| |. ... .  ||...    ...     . . .. .  ||.  .  . |.  . |     . .. |  .| .|..       .|.| ..  
serceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerfle.hw.qg.dvnnssdvysplrvlrklrnl......skpvvvqdil

GVGRTGTYIALDR-LMQAMQENDYI-DIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLR
|| ...| .|..  |.. ..   .   .   .  .|..|.  |..  .|.|..  |. ..|
GvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffr

subfamily_PTPRD_pd Subfamily PTPRD 721-880 7.2e-59 194.9 In-house 131-289 (564) alignment
Range on Protein: 721-880
Range on HMM: 131-289/564.0
IKCHEYWPADyNPVTYGSIQVSVQALQQYDHWVIREFSIS--QGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQktASDRPIVAHCSAGVGR
 |||.|||.. .. |||...|.... ... . .||.|...  . .| |. .|.||.||||||||... ..||..|.||.. .      ||| ||||||||
vkchkYWPek.gtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne..pdagPivVhCSaGVGR

TGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRRGEEEDT
|||.|..| ... ..|.. .||.... ..| |||.|||||.||||||| ... |  |..| .
TGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnteve

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 721-872 1.2e-56 186.9 In-house 130-279 (288) alignment
Range on Protein: 721-872
Range on HMM: 130-279/288.0
IKCHEYWPADYNPVTYGSIQVSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTasDRPIVAHCSAGVGRTG
 ||.||||.. .|. |||..| ..  .. ...| |.. . .  . ...|||....|||||||. .  .|...|.|  | |.     ||. ||||||||||
tkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad..tgpiivhCsaGvGrtg

TYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLL
|.|||| |..|..|.||||..|.....|.||. .|||.|||.||.|....| 
tFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 721-877 2.8e-46 153.1 In-house 139-295 (298) alignment
Range on Protein: 721-877
Range on HMM: 139-295/298.0
IKCHEYWPADyNPVTYGSIQVSVQALQQYDHWVIREFSISQGD--EIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREaIQKTASDRPIVAHCSAGVGR
.|.|.||| . .  |||.|.||... ...   ..|.. .|. .  . |.. | ||.||||.||| .. ..||..| ||   |. | ..|.. .|||||||
tkyhkywPde.gketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqagnkpvivqCsaGvgR

TGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRRGEE
.||.||.| ... ....  .|.| ..  .|..| ..||||.||.||.| |.. |  ...
sGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnd

subfamily_PTPN12_pd Subfamily PTPN12 721-874 5.9e-46 151.6 In-house 123-279 (290) alignment
Range on Protein: 721-874
Range on HMM: 123-279/290.0
IKCHEYWPAD-YNPVTYGSIQVSVQALQQYD-HWVIREFSISQGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQktASDRPIVAHCSAGVGR
.||. |||    .....|...|.... .. |  ..|| . . . .| ||..|.|...||||||| .. ..|.....|||  .  ..| |.| ||||||||
kkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGr

TGTYIALDRLMQAMQENDY---IDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRR
||| ||.|   ......     .|.| .. |.| ||. .|||..|| .....|..|...
tGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk

Y_phosphatase Protein-tyrosine phosphatase 721-869 1.3e-44 147.7 Pfam-A 82-234 (235) alignment
Range on Protein: 721-869
Range on HMM: 82-234/235.0
IKCHEYWP-ADYNPVTYGSIQVSVQ-ALQ-QYDHWVIREFSISQGDEI---RKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIqkTASDRPIVAHCSA
 ||..||| .. ...|||.|.| ..   . . .....|...... .|    |...|.|. .|||||||...  .||..| |..    .|.. |.| ||||
ekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsa

GVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVM
|||||||..||| |.. ..... .|.. |..|.| ||..|||...||||......
GvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 721-869 1.3e-44 147.7 In-house 82-234 (235) alignment
Range on Protein: 721-869
Range on HMM: 82-234/235.0
IKCHEYWP-ADYNPVTYGSIQVSVQ-ALQ-QYDHWVIREFSISQGDEI---RKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIqkTASDRPIVAHCSA
 ||..||| .. ...|||.|.| ..   . . .....|...... .|    |...|.|. .|||||||...  .||..| |..    .|.. |.| ||||
ekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsa

GVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVM
|||||||..||| |.. ..... .|.. |..|.| ||..|||...||||......
GvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

subfamily_PTPN6_pd Subfamily PTPN6 721-874 5e-44 145.5 In-house 138-299 (306) alignment
Range on Protein: 721-874
Range on HMM: 138-299/306.0
IKCHEYWPADYNPVTYGSIQVSVQALQQYDHWVIREFSIS---QGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTA--SDRPIVAHCSAG
 ||  |||.  .  .||.|.|.  . .. .....||.|.|   ...| |.. |||| |||||||| .. ..|||...|..  ....  . .||| |||||
ekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaG

VGRTGTYIALDRLMQAMQEND---YIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRR
.|||||.| .| |.. ....     |||  ..  .| ||. .||||.|| |... .   ...
iGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet

subfamily_PTPRG_pd Subfamily PTPRG 721-882 9e-43 141.3 In-house 131-297 (563) alignment
Range on Protein: 721-882
Range on HMM: 131-297/563.0
IKCHEYWPAdYNPVTYGSIQVSVQALQQYD-----HWVIREFSISQGDE---IRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAiqKTASDRPIVAHC
 ||. |||.  ...|||..||  .. ..       . ||... . ....    .. .|||. .|||||||...   | ||.    |  . |   ||| ||
rkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaa..nkaeaGPivvHc

SAGVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRRGEEEDTGE
|||||||||||.|| |.. .|... ...||..  .|.|||..|||| ||||.|. ...... .|.| . |
saGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellae

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 721-872 1e-41 137.6 In-house 126-276 (515) alignment
Range on Protein: 721-872
Range on HMM: 126-276/515.0
IKCHEYWPA-DYNPVTYGSIQVSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTAsdRPIVAHCSAGVGRT
||| .|||    . | .|||.|.. .|.     ..|.. . .||..| .||.||  |||.||| .| ..| ... |.   .. .   |.. |||||||||
ikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt..hpliihcsaGvGrt

GTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLL
| .|..|  .  ... . .|.| ..  .| .| ..|||. || ||.. |.. |
Gvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 721-873 3.6e-40 132.7 In-house 127-278 (315) alignment
Range on Protein: 721-873
Range on HMM: 127-278/315.0
IKCHEYWPA-DYNPVTYGSIQVSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAiqKTASDRPIVAHCSAGVGRT
|||  |||  . . | .|||.|..  |..    |.|.. . ...| |..||..|  |||.||. .| ..| ... |.    .   . ... |||||||||
ikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad..ngkkefsllvhcsaGvGrt

GTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLR
|  |..|  .. ..... .|.| .. ..| .| ..||||..| ||.. |.. | 
Gvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 721-871 1.1e-36 121.3 In-house 104-263 (270) alignment
Range on Protein: 721-871
Range on HMM: 104-263/270.0
IKCHEYWPADYNP---VTYGSIQVSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPDKTW------TMLDFVRTVREAIQKTASDRPIVAH
 ||  ||||. .    ...| |.| ... .. . .....  . .  |.|.|. ... .||||||| ..        .|  .|.||.  ....   |.. |
kkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvH

CSAGVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDL
|||||||||| ||||  .....|.  .|.  || |.| .|  .||. .|| |... |.  
csaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavvey

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 721-869 6.8e-35 115.4 In-house 85-236 (237) alignment
Range on Protein: 721-869
Range on HMM: 85-236/237.0
IKCHEYWPADYNPVTYGSIQVSVQALQQYDHWVIREFSISQ---GDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTASDRPIVAHCSAGVG
.|||.|||   .| .|| . ||..  ...  . .| . .|.     |.| . ||.| ||||.|||..| ..| | . . .  .. .   | . |||||||
lkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvg

RTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVM
||| .. .| ...  .|.  .||.  .  .  .| ...||. ||.|||. ..
rtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 721-874 7.6e-34 112.0 In-house 126-280 (287) alignment
Range on Protein: 721-874
Range on HMM: 126-280/287.0
IKCHEYWPADYNpVTYGSIQVSVQALQQYDHWVIREFSISQGD---EIRKLTQYHFMSWPDHG-VPDKTWTMLDFVRTVREaiQKTASDRPIVAHCSAGV
 .|..||| . . |..|  ....   ........|.. . . .   . ....||.. .|...| |...   .| . . ...  |.  .. .|| |||..|
evcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemykt..qrkrgntsivvhCsdtv

GRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRR
||.....| .  ..  ...  ||.| .. ..|.|. ..||| .||.|| . |.  |  
GrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleylds

subfamily_PTPN23_pd Subfamily PTPN23 721-874 1.6e-32 107.5 In-house 123-282 (288) alignment
Range on Protein: 721-874
Range on HMM: 123-282/288.0
IKCHEYWPADY-NPVTYGSIQVSVQALQQYDHWVIREFSIS--QGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVRE--AIQKTASDRPIVAHCSAG
 |...|||.|  ..|..| ..|...  .. ...| |.....  . |......  ...|||..|||.   |.|.|.  |..    ..  |. |.| |||||
pkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaG

VGRTGTYIALDRLMQAMQEN-DYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRR
|||||..  .   .......   .||  ..  .| || .|||...|. |  | |.   ||
vgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 721-874 3.8e-26 86.6 In-house 115-268 (283) alignment
Range on Protein: 721-874
Range on HMM: 115-268/283.0
IKCHEYWPADyNPVTYGSIQVSVQALQQYDHWVIREFSISQG---DEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVreAIQKTASDRPIVAHCSAGVG
|||  ||| .   . ||   |...     . ..|.|. . .     .   |. | .  | . |      ... | . .  . |.   . ||| |||.|.|
ikCsqyWPkr.GsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvi..slqteskkgPivvhCstgiG

RTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRR
||...||.   .. .. .  .|.| ..  || ||  .|||  || ..|| |..    
rtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalc

0049260 (Phosphotyrosine protein) phosphatases II 721-866 5.2e-26 86.6 In-house 49-144 (152) alignment
Range on Protein: 721-866
Range on HMM: 49-144/152.0
IKCHEYWpadynpvtygsiqvsvqalqqydhwvirefsisqgdeirkltQYHFMSWPDHGVPDKTWTMLDFVRTVREAiqKTASDRPIVAHCSAGVGRTG
.||..|.                                          ||... |||||||| .  .|.... ....  .  .. |.. ||||||||||
lkceqyi..........................................qylhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtg

TYIALDRLMqamqenDYIDIFGIICEMRMQRNHMVQTEKQYIFIHE
|..|.. ..        .... ..  .|..|...|... |..|..|
tlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

0044763 (Phosphotyrosine protein) phosphatases II 721-872 1.3e-23 78.9 In-house 64-171 (178) alignment
Range on Protein: 721-872
Range on HMM: 64-171/178.0
IKCHEYWPADYNpvtygsiqvsvqalqqydhwvirefsisqgdeirklTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQktASDRPIVAHCSAGVGRTG
.||..||| ...                                     ||... .||||||| .. .|.||. ..||..   ...|.. ||||||||.|
lkcdpywpeeag....................................iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaGvgRsg

TYIALDRLMQAmqendYIDIFGIICEMRMQRNhMVQTEKQYIFIHECVMDLL
| .|.. ...       .... .| ..|..|. .|... |. ...|. . ||
tlvaaylmkkl.....glsleeaielvrerRp.ivpnpgqlrqLyefelrll

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 721-869 2.5e-23 77.3 In-house 120-274 (287) alignment
Range on Protein: 721-869
Range on HMM: 120-274/287.0
IKCHEYWPADYNPVTYGSIQVSV--QALQQYDhWVIREFSISQ--GDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVR---EAIQKTASDRPIVAHCS
 ||..|||    |.  |   | .  .  .. . . .| . . .  . | | . |....||||....  .  .. ||  |.   |. ....   |.| |..
lkcykywPerevPmrvGGysvvlldydikePe.ygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhdd

AGVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVM
.|.||.|...|.  |.. ...   .|.  ..  .|..|. .||.  |. .. | ..
vGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv

subfamily_PTPRA_pd Subfamily PTPRA 722-877 4.1e-47 155.7 In-house 142-300 (330) alignment
Range on Protein: 722-877
Range on HMM: 142-300/330.0
KCHEYWPADyNPVTYGSIQVSVQALQQYDHWVIREFSIS-QGDE-----IRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTASdrPIVAHCSAG
||. ||| .   |||| |.|.|.  .   .. .|.| .  ..|.      | ..|.|| |||| ||| ..  ||.... |..  |..|.  ||| |||||
kcaqywPde.GlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag..pivvhcsaG

VGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRRGEE
||||||.|.|| ... .. .  .|.|... ..|.|| .||||..|| ||.. ...    |. 
vGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdt

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 722-870 2.6e-46 153.4 In-house 139-289 (319) alignment
Range on Protein: 722-870
Range on HMM: 139-289/319.0
KCHEYWPADYNpVTYGSIQVSVQALQQYDHWVIREFSISQ---GDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTASDRPIVAHCSAGVGR
|| .||| . . ....  .|.|..... . .|.|.. .|.     .|||.||.||. |||.|||| .  .. .|. ||   .|    ..|| ||||||||
kcsqywplkiv.ikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGr

TGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMD
||.||.|| |.. |.|.. .|.. .. ..| |||..||   || ||.  ...
tGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 722-881 2.9e-46 153.0 In-house 130-292 (305) alignment
Range on Protein: 722-881
Range on HMM: 130-292/305.0
KCHEYWPADYNP-VTYGSIQVSVQALQQYDHWVIREFSISQ---GDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAiQKTASDRPIVAHCSAGVG
||. |||   .  . .|...| ..  ...  ...|...||.    .| | ..||.. .|||||||... ..|.... |... ||   . |.. |||||||
kCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkd.qkkdkgvpllVhCsagvg

RTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRRGEEEDTG
|||..||.|  .. ... . .|.|... ..| .|  |||| .|| |.|. . .|.  |. .  |
RtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiig

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 722-870 9.8e-46 151.5 In-house 103-253 (284) alignment
Range on Protein: 722-870
Range on HMM: 103-253/284.0
KCHEYWPADYNpVTYGSIQVSVQALQQYDHWVIREFSISQ---GDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTASDRPIVAHCSAGVGR
|| .||| . . ....  .|.|..... . .|.|.. .|.     .|||..|.||. |||.|||| .  .. .|. ||   .|    ..|| ||||||||
kcsqywplkiv.ikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgr

TGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMD
||.||.|| |.. |.|.. .|.. .. ..| |||..||   || ||.  ...
tgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 722-872 2e-43 143.4 In-house 92-242 (250) alignment
Range on Protein: 722-872
Range on HMM: 92-242/250.0
KCHEYWPADyNPVTYGSIQVSVQALQQYDHWVIREFSISQGDEIRK--LTQYHFMSWPDHGVPDKTWTMLDFVRTVReAIQKTASDRPIVAHCSAGVGRT
..|.|||.. .. .||...||.   ...  ...|.. .|.  .  .  . |.||..||| |||... ..|.... |. | |. | ..|.. .|||||||.
tyhqywPve.kaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvq.asqqqagnaPvivqCsaGvgrs

GTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLL
|..||.| ... ....  .|.| .|  .| .| |.|....||.|..| ..  |
Gafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkal

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 722-873 2.1e-43 143.4 In-house 114-269 (274) alignment
Range on Protein: 722-873
Range on HMM: 114-269/274.0
KCHEYWPADYNP---VTYGSIQVSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTASD-RPIVAHCSAGVG
||..|.| . .     .|| ... |.   . ... .|......  . |... | . .|||| .||.. |.||.|. |.|. ....    |.| |||||.|
kCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiG

RTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLR
||| .|| .  .. ..|.  .|...|.|..|..|  ||||..|| .||. ..  |.
rtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk

subfamily_Ptp69D_pd Subfamily Ptp69D 722-877 2.8e-41 136.6 In-house 132-291 (307) alignment
Range on Protein: 722-877
Range on HMM: 132-291/307.0
KCHEYWPADyNPVTYGSIQVSVQALQQYDHWVIREFSISQGD-------EIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTasDRPIVAHCSA
||. ||| . . | ||.| | .   .. ....|||...|. .       . ||..|||...|.|  ||. . ..|.... |||  ..     ||| ||||
kcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln..rsPivvhCsa

GVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRRGEE
||||.|...||| |.| ....| .||| .....| ||| .||  .||.|..  ..|    |. 
GvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdt

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 722-876 8e-41 135.0 In-house 133-283 (315) alignment
Range on Protein: 722-876
Range on HMM: 133-283/315.0
KCHEYWPADynPVTYGSIQVSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREaiQKTASDRPIVAHCSAGVGRTGT
|. .||| .   |.|| | |. .  ...... .| .|.  ||.||.. |.|. |||| |||  | ......|||.    .|.|  .|| |||||||||||
kaekywpdk..kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkq..hhtnsvgaivvhcsaGvGrtGt

YIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRRGE
.|.|| ... .. .. ||.. .|  .| .| .|||. .|| ||.. ... .  |.
fitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgd

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 722-874 9.6e-39 128.3 In-house 132-286 (297) alignment
Range on Protein: 722-874
Range on HMM: 132-286/297.0
KCHEYWPaDYNPVTYGSIQVSVQALQQYDHWVIREFSISQGD--EIRKLTQYHFMSWPDHGVPD--KTWTMLDFVRTVREAIQKTASDrPIVAHCSAGVG
||  ||. |   .|.|.. | ......    . ||.....|.    | . ||.|..|||. |.   .. ..|...  ||.  ...|.  |.. ||.||||
kcaryWs.dkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.PllvhclaGvG

RTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRR
||| ....|  .  ..... .||||..  .| .| ..|||..|| |... |.. |  
rtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlealls

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 722-888 4.2e-37 123.0 In-house 131-304 (325) alignment
Range on Protein: 722-888
Range on HMM: 131-304/325.0
KCHEYWPAD-YNPVTYGSIQVSVQALQQYDHWVIREFSISQG--DEIRKLTQYHFMSWPDHGVPDKTWTMLD---FVRTVREAIQK-TASDRPIVAHCSA
.|  ||| .  . .|.|...|........  .| | . . |    | | . |....||.| ||. .  |..     | .| | ..  | .  ||. ||||
rcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsa

GVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRRGEEEDTGESIYVNL
||||||..|.|  ... . |.  .|||| .  .| .|  ||.|  |||.|.|.... .  |. .    |.  .|
GvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeakl

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 722-875 3.9e-34 112.8 In-house 127-282 (439) alignment
Range on Protein: 722-875
Range on HMM: 127-282/439.0
KCHEYWPADYNpVTYGSIQVSVQALQQYDHWVIREFSIS----QGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTASdRPIVAHCSAGVG
. . |||.| . | || | | |.   .  ..||| | .     ...  | . |.|...|||. || ..  .|||.|..  | .|     |.| |||||||
esykywpsdae.vcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeey.gpvvvhcsagvG

RTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRRG
|||| ||||  .. .. .. .|| ||.  .| ||..|||.  ||.||...|.. .  |
rtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyG

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 722-870 7.8e-33 108.6 In-house 92-238 (239) alignment
Range on Protein: 722-870
Range on HMM: 92-238/239.0
KCHEYWPADYnpVTYGSIQVSVQALQQYDHWVIREFSISQG--DEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAiqKTASDRPIVAHCSAGVGRT
|||.|||       |  ..|...  . .  ..|| | .||    | | . ||||  |||.|||. . ..| . | . .        || | |||||||||
kchqywpdst..skycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkd..slpgarpwvihcsagvgrt

GTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMD
|... .| ...  ...  .|||  .  .| .| ||||| .||.||| .|..
gaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 722-869 9.7e-33 108.3 In-house 93-238 (239) alignment
Range on Protein: 722-869
Range on HMM: 93-238/239.0
KCHEYWPADYnpVTYGSIQVSVQALQQYDHWVIREFSISQG--DEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAiqKTASDRPIVAHCSAGVGRT
|||.|||       |  ..|...  . .  ..|| | .||    | | . ||||  |||.|||. . ..| . | . .        || | |||||||||
kchqywpdst..skycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkd..slpgarpwvihcsagvgrt

GTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVM
|... .| ...  ...  .|||  .  .| .| ||||| .||.||| .|.
gaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl

0036282 (Phosphotyrosine protein) phosphatases II 722-866 7.7e-32 105.8 In-house 53-164 (174) alignment
Range on Protein: 722-866
Range on HMM: 53-164/174.0
KCHEYWPAdynpvtygsiqvsvqalqqydhwvirefsiSQGDEIRKLTQYHFMSWPDHGVPDKTWtMLDFVRTVREAIQKtASDRPIVAHCSAGVGRTGT
||. |||                                . |. |   ||... |||||||| .  .|.||. |.||...  ...|.. |||||||||||
kcinywpe..............................lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGt

YIALDRLMQAMQeNDYIDIFGIICEMRMQRNHMVQTEKQYIFIHE
 .|...... .  ....|.. .. |.|.|| .||||. ||.|...
lvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy

0046846 (Phosphotyrosine protein) phosphatases II 722-872 1.2e-27 92.2 In-house 64-173 (176) alignment
Range on Protein: 722-872
Range on HMM: 64-173/176.0
KCHEYWPADYNPVTygsiqvsvqalqqydhwvirefsisqgdeirkltQYHFMSWPDHGVPDKtWTMLDFVRTVREAIQKTasdRPIVAHCSAGVGRTGT
||. |||  ...                                    ||... ||||||||    .|.... .|||...    .|.. |||||.|||||
kcpnywpeleklgi..................................qylhlpwpDhgvpdl.elllellefirealkeg...gpvlVHCsaGigRtgt

YIALDrlmqAMQENDYIDIFGIICEMRMQRN-HMVQTEKQYIFIHECVMDLL
..|..     .. .  .... .....|.||  ..|||..|| |..|... ||
lvaay....llelekglsveealalvreqRplgavqtpeQyrflyefellll

subfamily_CG7180_pd Subfamily CG7180 722-870 1e-26 88.2 In-house 125-288 (296) alignment
Range on Protein: 722-870
Range on HMM: 125-288/296.0
KCHEYWPADYnPVTYGSIQVSVQALQQYDHWVIREFSISQG------------DEIRKLTQYHFMSWPD-HGVPDKTWTMLDFVRTVREAIQKT---ASD
....||| .     || | | .   .|| . .||.| . .              | | ......  |.  . ||  | ......| ||  ..|.      
mypsywpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpee

RPIVAHCSAGVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMD
 |.| ..| |..|.| |.|.|  .. ..... .|.|. .  .| .|...|.. ..| .| . . .
gPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlle

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 722-872 4.1e-22 73.2 In-house 126-293 (301) alignment
Range on Protein: 722-872
Range on HMM: 126-293/301.0
KCHEYWPA-DYNPVTYGSIQVSVQALQQYDHWVIREFS-----------------ISQGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTa
||..|||  . .  ..| ..| ..  | |  .|||...                 ...  . ....|..  .||..||     |.|  .  |  . ||  
kceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqki.

SDRPIVAHCSAGVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLL
.  |.| |||..|.|.|.|....  .   . .  .|.|...  .| ..  .|.| .||..|.. .   |
gggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 722-871 2e-17 57.8 In-house 122-268 (281) alignment
Range on Protein: 722-871
Range on HMM: 122-268/281.0
KCHEYWPADY-NPVTYGSIQVSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVReaiqktASDRPIVAHCSAGVGRTG
|| ||.| .    . .  . || .        |   . .|   | | .|.. .  |||  ||. .  ||  .| .|      |   | | ||||||||.|
kcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkir......arstppvihcsagvgrsg

TYIALDRLMQAMQEN-DYIDIFGIICEMRM-QRNHMVQTEKQYIFIHECVMDL
| .|..  .|...      ||  |.  .|.  |   ||| .||..| . ..|.
tlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 722-871 1.6e-11 38.9 In-house 112-258 (290) alignment
Range on Protein: 722-871
Range on HMM: 112-258/290.0
KCHEYWPADYN-PVTYGSIQVSVQALQQYDHWVIREFSISQGDEIR-KLTQYHFMSWPDHGVPDKTWTMLDFVRTVReaiqktASDRPIVAHCSAGVGRT
 | .| |   .  .... ..|. .   . |   .||  .  .||   ..| . . .| .  |...| |.|. ...|.      ||. |.. ||  |. | 
aCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk......asktpvivHcvdGiSrs

GTYIALDRLMQAMQ-ENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDL
 .  |..  .| .   .. . .  .. ..| ||.......... |.   .. |
AalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivll

0041856 (Phosphotyrosine protein) phosphatases II 723-874 2.3e-29 97.7 In-house 67-173 (182) alignment
Range on Protein: 723-874
Range on HMM: 67-173/182.0
CHEYWPadynpvtygsiqvsvqalqqydhwvirefsisqGDEIRKLTQYHFMSWPDHGVPDkTWTMLDFVRTVREaiqktaSDRPIVAHCSAGVGRTGTY
.. |||                                  .. |  .||....|||||||| . ..|||...|.|      ...|.. |||||||||||.
eelywp.................................ellerlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtl

IALDrLMQAMqenDyIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRR
.|.. ||  .   . .... .....|..|..||.|. ||.|.. ....||..
vaay.lmkkl...g.vsleeavklvrsrRpgmvitpnqyfflqlallellll

0051082 (Phosphotyrosine protein) phosphatases II 723-868 2.6e-23 77.7 In-house 49-149 (151) alignment
Range on Protein: 723-868
Range on HMM: 49-149/151.0
CHEYWPADYnpvtygsiqvsvqalqqydhwvirefsisqgdeiRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREaiqktASDRPIVAHCSAGVGRTGTY
|.||.|.                                    ..........|||.|.|. . ..|.|.. ...      .. |.. |||||.||||| 
cpeylpelg..................................ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtl

IALDRLMQAmqendyIDIFGIICEMRMQRNHMVQTEKQYIFIHECV
.||.....       .... .. |.|..| ..||.. |..|.. ..
valylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfal

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 723-865 1.9e-16 54.7 In-house 132-274 (301) alignment
Range on Protein: 723-865
Range on HMM: 132-274/301.0
CHEYWPADY-NPVTYGSIQVSVQALQQY--DHWVIREFSISQG---DEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREaiqktaSDRPIVAHCSAGV
|.|| | .  . .  |  .. ..  ..   .. . |.. .       . | .| | ...|.|.|||     . |..  |..      |..||| |||||.
ceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk......sekPivvhcsaGi

GRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIH
||. ..|. . | .... .  |..   . ..| .| . |||..|  .. 
Grsvafigteylareveadptieltealkhlrehrwngvqtnsqlywmt

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 726-865 2.3e-12 41.5 In-house 50-197 (199) alignment
Range on Protein: 726-865
Range on HMM: 50-197/199.0
YWPADY-NPVTYGSIQVSVQALQQYDHWVIREFSI----SQGDEIRKLTQYHFMSWPDHGVPDKTwTMLDFVRTVREAIQKT--ASDRPIVAHCSAGVGR
|||.       |||. |.....     ..|  . .    .     |....| | || ..  |. .  .. || . ||  .|     | |.. ||| | | 
ywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgf

TGTYIALDRLMQAMQEN--DYIDIFGIICEMRMQRNHMVQTEKQYIFIH
|| ..|||  ... .|     .|.| .   .|  |  .. . ..| ||.
tgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 726-865 2.3e-12 41.5 In-house 49-196 (198) alignment
Range on Protein: 726-865
Range on HMM: 49-196/198.0
YWPADY-NPVTYGSIQVSVQALQQYDHWVIREFSI----SQGDEIRKLTQYHFMSWPDHGVPDKTwTMLDFVRTVREAIQKT--ASDRPIVAHCSAGVGR
|||.       |||. |.....     ..|  . .    .     |....| | || ..  |. .  .. || . ||  .|     | |.. ||| | | 
ywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgf

TGTYIALDRLMQAMQEN--DYIDIFGIICEMRMQRNHMVQTEKQYIFIH
|| ..|||  ... .|     .|.| .   .|  |  .. . ..| ||.
tgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

0048076 (Phosphotyrosine protein) phosphatases II 741-871 1.8e-29 97.7 In-house 20-142 (145) alignment
Range on Protein: 741-871
Range on HMM: 20-142/145.0
VSVQALQQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKtasDRPIVAHCSAGVGRTGTYIALDRLMQamqeNDyIDI
.... |...... .  ..  . .. |. .||....|||||||| . ..|.|.. ..||...   ..|.. |||||||||||..|.. ...    .. ...
ldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke...ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsl

FGIICEMRMQRNHMVQTEKQYIFIHECVMDL
. .. ..|.|| ..|... |..|..|... |
eealelvrsqrpgavpnpgqlrflyefelel

0048179 (Phosphotyrosine protein) phosphatases II 742-866 4.7e-27 89.9 In-house 21-139 (144) alignment
Range on Protein: 742-866
Range on HMM: 21-139/144.0
SVQALQQYDHWVIREFSISQGDEIRKLT--QYHFMSWPDHGVPDKTWTMLDFVRTVREAIQktaSDRPIVAHCSAGVGRTGTYIALDRLMqamqENDyID
... |...... .  .. .   |  . .  ||....|||||||| .  .|.|.. ..||..   ...|.. |||||||||||..|.....    ... ..
dlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaaylmk....klg.ls

IFGIICEMRMQRNHMVQTEKQYIFIHE
.. .. ..|..| ..|... |..|..|
leealalvrsrrpgavpnpgqlrfLle

subfamily_ptpA1_pd Subfamily ptpA1 743-831 3.4e-14 47.4 In-house 162-255 (418) alignment
Range on Protein: 743-831
Range on HMM: 162-255/418.0
VQALQQYDHW-VIREFSISQGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTV--REAIQKTASDR--PIVAHCSAGVGRTGTYIALDRLMQA
|. .|. ..  . |.  ..   | | .|||..  |||| .||.|  . ......  |.     .|||  ||. |||||||||||. .   .|. 
veviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkk

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 744-873 2.1e-20 67.7 In-house 155-277 (312) alignment
Range on Protein: 744-873
Range on HMM: 155-277/312.0
QALQQYDHWVIREFSISQGDEiRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVReaiqKtaSDRPIVAHCSAGVGRTGTYIALDRLMQAMQENDYIDIFGI
.. ..  | |..    . |.|  || .| . ||||||.||   | | .. .|.    |    .|..|||||||||||| . .. .. |..     ..  .
kskdkithrvlkvvvkatgqe.sklnhyqwaswpdhgmpdscdtalrllsavk....k..dkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkds

ICEMRMQRNHMVQTEKQYIFIHECVMDLLR
   .| .|   |..  ||..   ||...| 
fvllrkdrarsvrvfpqyvyalrcvlefly

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 746-872 1.9e-27 90.7 In-house 122-237 (392) alignment
Range on Protein: 746-872
Range on HMM: 122-237/392.0
LQQYDhwvirefsisQGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVReaIQKTASDRPIVAHCSAGVGRTGTYIALDRLMQAMQENDYIDIFGIIC
|.. |          .||. |  .|.||  |||..|| .| ..| |.. |.  ..     .|.. ||||||||||  |..| ..   ..   .|.| .. 
lkegd..........kgddartvaqfhftewPdkdvpkhtssllkfikevk..adfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvt

EMRMQRNHMVQTEKQYIFIHECVMD-LL
..| .| .||||..|| ||. .|.. ||
nirrkrpymvqtkeqyafiygavledll

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 747-868 1.2e-09 32.3 In-house 152-275 (303) alignment
Range on Protein: 747-868
Range on HMM: 152-275/303.0
QQYDHWVIREFSISQGDEIRKLTQYHFMSWPDHGVPDK-TWTMLDFVRTVREAIQKTASDRPIVAHCSAGVGRTGTYIALDRL-MQAMQENDYIDIFGII
.  | ||..  |.|.||    |  .|. .||   .| . .  ..  .  ..  ..| .  .| |    .|.||.||.  ..   .   .|.  .|.   .
elgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkcl

CEMRMQRNHMVQTEKQYIFIHECV
  .|  | | ||   |. ...  .
envrngrlhavqnlsqfsvvytll

subfamily_PTPDC1_pd Subfamily PTPDC1 757-870 2.8e-10 34.9 In-house 71-174 (182) alignment
Range on Protein: 757-870
Range on HMM: 71-174/182.0
FSISQGDEIRKLTQYHFMSWPDHGVPDKTwTMLDFVRTVREAIQKTasdrPIVAHCSAGVGRTGTYIALDrLMQAMQendyIDIFGIICEMRMQRNHMVQ
|| .. .  ..   .. ..|.|.||.  . ..|| |. |  |.|.      .  || || ||||  ||   |. | .    ..    |  .| .| . .|
fsYdlealmeqgiyvynfgwkDygvasle.riLdivkvvafalqeg....kvavhChaGlGrtGvliacy.lvyakr....ltaekaiklvrskrpksiq

TEKQYIFIHECVMD
| .|  ...|  . 
treqvelvkefalf

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 758-876 9e-28 91.8 In-house 81-198 (440) alignment
Range on Protein: 758-876
Range on HMM: 81-198/440.0
SISQGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVREAiQKTASDRPIVAHCSAGVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQT
|  .| | | | |||. .|||.|||  .  .| ... | |. |. |.. |.. |||||.||||  ||.| ...  . .| |||| .|  || .| .||||
syingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnes.qekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqt

EKQYIFIHECVMDLLRRGE
 .|| |.||.|.. |  |.
peqyafvheavlegllcgd

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 761-874 2.2e-24 80.7 In-house 181-289 (305) alignment
Range on Protein: 761-874
Range on HMM: 181-289/305.0
QGDEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVReaiqktASDRPIVAHCSAGVGRTGTYIALDRLMQAMQENDYIDI-FGIICEMRMQRNHMVQTEK
 | . || |.||.. ||| |||    ..|...   |      .|  ||| |||||.||||. . |. ... . . . |.    |.  .| |||  .||..
pgekarkvthyhwidwpdrgvpaadlailellekar......pskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtda

QYIFIHECVMDLLRR
||.|.|. ... .|.
qylfvhqvilnyfrk

0043147 (Phosphotyrosine protein) phosphatases II 762-867 1.6e-27 91.7 In-house 59-156 (172) alignment
Range on Protein: 762-867
Range on HMM: 59-156/172.0
GDEIRKLTQYHFMSWPDHGVPdKTWTMLDFVRTVREAIqKTASDRPIVAHCSAGVGRTGTYIALDRLMqamqenDYIDIFGIICEMRMQRNHMVQTEKQY
 .. |   ||....|||||||  .  .|.|.. ..|..    .. |.. ||||||||||| .|.. ..        .... .....|..|...||.. ||
ellerlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqy

IFIHEC
.|....
rflyyf

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 763-872 8.7e-20 65.9 In-house 168-271 (288) alignment
Range on Protein: 763-872
Range on HMM: 168-271/288.0
DEIRKLTQYHFMSWPDHGVPDKTWTMLDFVRTVreaiqkTASDRPIVAHCSAGVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYI
.|   . . |.  |.|.|||..  . | ..  .       . ..||| |.||||||||| |     ..... .|.. |  .. ..| .| . .|||.||.
eekvivkilhlleWdddgvPenylsplrllevl......kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqyl

FIHECVMDLL
..| ||.. |
yvhrcvleel

PTEN_1 763-852 5.4e-10 34.4 In-house 89-175 (196) alignment
Range on Protein: 763-852
Range on HMM: 89-175/196.0
DEIRKLTQYHFMSWPDHGVPDKTwTMLDFVRTVREAIQKTASDRPIVAHCSAGVGRTGTyIALDRLMQAMQeNDYIDIFGIICEMRMQRN
.....  .|. ....|||.|.    ..|... . |....  . . .. || ||.||.|| ..   ||....  .. . . ...|.|....
effksgveylhfpieDhgapsls.elfdicksfiewllsdpngnvVlVHCkaGlgRsGt.vvaayLmykgk.ltadeAlelvrekRppga

0049772 (Phosphotyrosine protein) phosphatases II 766-874 7.4e-21 70.6 In-house 178-282 (314) alignment
Range on Protein: 766-874
Range on HMM: 178-282/314.0
RKLTQYHFMSWPDHGVPdKTWTMLDFVRTVREAiqktASDRPIVAHCSAGVGRTGTYIALDRLMQAMQendyIDIFGIICEMRMQRN-----HMVQTEKQ
|   .|. . .||...|  .  ...|.. ..||      ..|.. ||.||.|||||..... || ...    ...  .. ..|..|      ..... .|
rlgikylripvpDgsap.lledfdeflefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleq

YIFIHECVMDLLRR
|.||.|.....|..
yefilealleylkf

PTPc_DSPc_SM00012 768-869 1.9e-36 119.8 In-house 2-104 (105) alignment
Range on Protein: 768-869
Range on HMM: 2-104/105.0
LTQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKTASDRPIVAHCSAGVGRTGTYIALDRLMQAMQEN-DYIDIFGIICEMRMQRNHMVQTEKQYIFIHE
...||...|||||||...  .|...| |..  .| .|  |.| |||||||||||..||| |.| .... . .||| |..|.|.||..||||| ||.|...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

CVM
...
all

0038934 (Phosphotyrosine protein) phosphatases II 769-865 8.9e-10 34.0 In-house 80-170 (194) alignment
Range on Protein: 769-865
Range on HMM: 80-170/194.0
TQYHFMSWPDHGVPDKTWTMLDFVRTVREAIQKtASDRPIVAHCSAGVGRTGTYIALdrlmqAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIH
 .|. . .||.|..  . ..|.|.. | | ...  ..  .. || ||.||||| .|      .. .   ..    |  .|. |...... ...  ..
ieylklpfpddgtvPsleillrfldlvdeflne.dpggvvaVHCkaGlgRtGtlvaa.....YLiyrlgmsaeeAialfrekRpgaipnqdyleall

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 770-870 2.2e-16 54.6 In-house 219-342 (350) alignment
Range on Protein: 770-870
Range on HMM: 219-342/350.0
QYHFMSWPDHGV---PDKTWTMLD----FV-RTVREAIQKTASDRPIVAHCSAGVGRTGTYIALDRLMQ------AMQE----NDYI----D-IFGIICE
| ..  |.| ..   | .  ..|.    ..   . |   ..|   ||. |||||||||||...|| |..       ...     |.     | |. |. |
qlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivne

MRMQRNHMVQTEKQYIFIHECVMD
.| ||  |||. .|.|||.|... 
lrkqrismvqnldqfifiYeallf

subfamily_PTEN_pd Subfamily PTEN 770-864 3.6e-07 25.3 In-house 81-172 (184) alignment
Range on Protein: 770-864
Range on HMM: 81-172/184.0
QYHFMSWPDHGVPdKTWTMLDFVRTVREAIQKTAsDRPIVAHCSAGVGRTGTYIALdRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFI
. . .   ||  | .   . ..|..... ...   .. .| || || ||||. |.   |..... ..  ..  .  |.|.. .. |.   |  ..
rvavypfdDhnpp.plelleeivediekwleedk.knvvvvHCkaGkGRtGvliva.yllkslllekaeealelfaeaRtknkkgvtiPsqrRYv

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 771-869 6.6e-17 55.9 In-house 193-285 (302) alignment
Range on Protein: 771-869
Range on HMM: 193-285/302.0
YHFMSWPDHGVPDKTWTMLDFVRTVrEAIQKTasdrpIVAHCSAGVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVM
 .| .||||| |... | || ..   |. .|.     .. ||||||||||| .|.   .|  ....  |.  |.. .|  |   ||.|.| |..  || 
lafsawpdhGapkeaytaldilkfc.esykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvt

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 771-871 3.6e-12 40.3 In-house 186-284 (302) alignment
Range on Protein: 771-871
Range on HMM: 186-284/302.0
YHFMSWPDHGVPDKTWTMLDFVRTVreAIQKTASDRPIVAHCSAGVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMD
|..  |... ||.|  ..   .  |    .|. .| ..|     |.|| |. ..|   .. .|...   |  |.  .| || ..|.. |||.... ... 
yvltnWkqkkvpvkyaeliktaakv..fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialll

L
.
y

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 774-872 1.6e-16 55.1 In-house 175-270 (285) alignment
Range on Protein: 774-872
Range on HMM: 175-270/285.0
MSWPDHGVPDKTWTMLDFVRTVREAIQKtasDRPIVAHCSAGVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLL
  |||.  |. .  |... . |..   |   ..||. ||||||||| |.. .|     . ||  |... |. |||  | . ||.  |..|..  .|. .
pwwpdqlapedarpmielykwvkkvnpk...ekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 794-870 6.6e-20 66.2 In-house 181-257 (267) alignment
Range on Protein: 794-870
Range on HMM: 181-257/267.0
TVREAIQKTASDRPIVAHCSAGVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMD
 .    |    .||.| .||.||||.||.. .|  .. .....  |||  . ..| ||  .|.|  .||.||| . .
gilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae

subfamily_eak_pd Subfamily eak 794-875 4.7e-08 26.8 In-house 226-308 (332) alignment
Range on Protein: 794-875
Range on HMM: 226-308/332.0
TVREAIQKTASDRPIVaHCSAGVGRTGTYIALDRLMQAM---QENDYiDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRRG
|..  |    |  ||.  .. |  |.|... .| |.. .   ..| |  .  .|  .. .|.| | ...|. ||.| |.| |.| 
tlkkyihtppsfapii.qsarGsaraGvfvvidllirlidnkkknly.svedlilkvkskrihsvlvalqhsfiyeivldyllrr

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 800-871 1.6e-10 34.8 In-house 260-343 (349) alignment
Range on Protein: 800-871
Range on HMM: 260-343/349.0
QKTASDRPIVAHCSAGVGRTGTYIALDRLMQ--AMQENDYID----------IFGIICEMRMQRNHMVQTEKQYIFIHECVMDL
 .|.   ... ||||| ||||... || |..   . .|..            |. |. |.| ||  |||  .|.|.|.|...  
ldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLky

subfamily_CG42327_pd Subfamily CG42327 803-868 1.9e-13 44.8 In-house 245-311 (319) alignment
Range on Protein: 803-868
Range on HMM: 245-311/319.0
ASDRPIVAHCSAGVGRTGTYIALDRLMQAMQEN-DYIDIFGIICEMRMQRNHMVQTEKQYIFIHECV
 |  |.| ||| ||||||. || |  .. ..|.   .||  ..  .| .| . |.| .|| ||.  .
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 804-870 5.9e-11 36.8 In-house 227-293 (297) alignment
Range on Protein: 804-870
Range on HMM: 227-293/297.0
SDRPIVAHCSAGVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMD
 . ... ||||||||.|  .  | ... .. .   |.  |.  .| ||  .||| .|. .... |. 
rnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 809-875 3.3e-15 50.2 In-house 2-68 (69) alignment
Range on Protein: 809-875
Range on HMM: 2-68/69.0
VAHCSAGVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRRG
| |||.| |||||.||.   |  .. .  .|||  .  ||  |  ||  | .|||||. ... |. |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 809-875 1.6e-14 48.0 In-house 1-67 (69) alignment
Range on Protein: 809-875
Range on HMM: 1-67/69.0
VAHCSAGVGRTGTYIALDRLMQAMQENDYIDIFGIICEMRMQRNHMVQTEKQYIFIHECVMDLLRRG
| |||.| |||||.||.   |  .. .  .|||  .  ||  |  ||  | .|.|||. ... |. |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG