Gene PTPDC1 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily PTPDC1
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP013_AA protein Get Run
AqueP013_AA_118-282 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPDC1_pd Subfamily PTPDC1 106-288 4.1e-89 291.8 In-house 2-182 (182) alignment 
Range on Protein: 106-288
Range on HMM: 2-182/182.0
RWRKEEtgVAFDGLYSHWVTDNILAMARPSTQLFTQYKLLDQFKESGINAVINLQTAGEHAHCGPPQENSGFTYKPEDLMRQNIYYYNYPLPDYSTFSVE
||..||  .|..||||.|||..|||.||||.. ...|||||.||||||.||||||..||||.|| ..|.|||.|..|.||.|.||.||....||...|.|
rwseee..qaikGlystWvtedilalarpsqeaideyklldkfkesgikavinLqekgehasCGagleesGfsYdlealmeqgiyvynfgwkDygvasle

NMLDVVKVIDFSCLNGRIAIHCHAGLGRTGSVIACYLVYSQRIGAEEAITKVRDKRPDSIQSRSQIELVVQFSLFLLSLWNLY
..||.|||..|.. .|..|.|||||||||| .|||||||..|. ||.||..||.|||.|||.|.|.|||..|.|||..|...|
riLdivkvvafalqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvkefalfliplrkvy
0046846 (Phosphotyrosine protein) phosphatases II 116-282 3.1e-36 120.1 In-house 7-173 (176) alignment 
Range on Protein: 116-282
Range on HMM: 7-173/176.0
FDGLYSHWVTDNILAMARPSTQLF----TQYKLLDQFKESGINAVINLQTAGEHAHCGPPqensgftYKPEDLMRQNIYYYNYPLPDYSTFSVENMLDVV
...|.......|.....|| .       | .. |...|| ||.||.||..  |..... |       . ...|.. .| |...| ||... . | .|...
gldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcp.......nywpeleklgiqylhlpwpDhgvpdlelllell

KVIDFSCLNG-RIAIHCHAGLGRTGSVIACYLVYS-QRIGAEEAITKVRDKRP-DSIQSRSQIELVVQFSLFLL
. |.    .| ....||.||.|||| ..|.||... . . .|||. .||..||  ..|...|.. . .| |.||
efirealkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellll
PTEN_1 105-280 2.2e-35 117.3 In-house 10-191 (196) alignment 
Range on Protein: 105-280
Range on HMM: 10-191/196.0
SRWRKEETGVAFDGLYSHWVTDNILAMARPSTQlFTQYKLLDQFKESGINAVINLQTAGEHAHCGPPQEN--SGFTYKPEDLMRQNIYYYNYPLPDYSTF
.. . ..| ..  .. . .....  |..|| .| ..  .|. .. ..  . . ||.  | ....    |   ||..| .|. ..... |...| .|. . 
kknlalptelldltyitsriiamgkapsrpllq.eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgap

SVENMLDVVKVIDFSCL----NGRIAIHCHAGLGRTGSVIACYLVYSQRIGAEEAITKVRDKR-PDSIQSRSQIELVVQFSLF
| . ..|..|... ..|    .. ...||.|||||.| |.|.||.|...  |.||.  ||.|| | ...|.|| .|. .|. .
slselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfael
0038934 (Phosphotyrosine protein) phosphatases II 120-278 1.8e-34 114.4 In-house 12-173 (194) alignment 
Range on Protein: 120-278
Range on HMM: 12-173/194.0
YSHWVTDNILAMARPSTQLFTQYklLDQFKESGINAVINLQTAGEHA-HCGPPQENSGFTYKPEDLMRQNIYYYNYPLPDYST----FSVENMLDVVKVI
.....|....|...|... ...|  .....  ... .... ..  .  ..     |....| ||.... .|.|...| ||. |      . . ||.|...
vgdiitgrfiafkvPlsgsldky..ieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdef

DFSCLNGRIAIHCHAGLGRTGSVIACYLVYSQRIGAEEAITKVRDKRPDSIQSRSQIELVVQFS
   . .| .|.||.||||||| ..|.||.|.... |||||  .|.|||..|......| .... 
lnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkry
0043147 (Phosphotyrosine protein) phosphatases II 119-284 6.6e-33 109.2 In-house 13-163 (172) alignment 
Range on Protein: 119-284
Range on HMM: 13-163/172.0
LYSHWVTDNILAMARPstQLFTQYKLLDQFKESGINAVINLQTAgehahcgppqensgfTYKPEDLMRQNIYYYNYPLPDYSTFSVENMLDVVKVIDF--
|. ....|...|.  |    .|  . ....|| ||....|| .                .| ||.|.|..| |. .| ||..... | .|.... ||   
ldlyyipdrfiatqgp..lrntladfwrmlkelgithivnltel...............lydpellerlgiqylylpwpDhgvpllellleflefidell

-SCLNGRIAIHCHAGLGRTGSVIACYLVYsQRIGAEEAITKVRDKRPDSIQSRSQIELVVQFSLFLLSL
  . .|....||.||.|||| ..|.||.. ... .|||.  ||.||| ..|. ||. .. .|. .|| |
alspggpvlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfeklllll
0041856 (Phosphotyrosine protein) phosphatases II 117-282 7.8e-33 109.0 In-house 15-171 (182) alignment 
Range on Protein: 117-282
Range on HMM: 15-171/182.0
DGLYSHWVTDNILAMARPSTQLF--------TQYKLLDQFKESGINAVINLQtagehahcgppqensGFTYKPEDLMRQNIYYYNYPLPDYSTFSVENML
 .........|......|.|.          | .. |...|| ||....||                .. | ||.|.|..| |...| ||....... .|
hsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt...............eelywpellerlgiqylylpwpDhgvpdldell

DVVKVIDFscLNGRIAIHCHAGLGRTGSVIACYLVYSQRIGAEEAITKVRDKRPDSIQSRSQIELVVQFSLFLL
| .. .     .|....||.||.||||...|.||........|||.  || .|| .... .|. .. .. |.||
dfieevle..eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallell
0044763 (Phosphotyrosine protein) phosphatases II 115-284 9.5e-32 105.4 In-house 17-173 (178) alignment 
Range on Protein: 115-284
Range on HMM: 17-173/178.0
AFDGLYSHWVTDNILAMARPStqlftqYKLLDQFKESGINAVINLQTAGEHAHCGppqensgftYKPEDLMRQNIYYYNYPLPDYSTFS-VENMLDVVKV
..|... ........... |.       . |...|| ||....|| .  |. ...         . |..... .| |...|.||.....  | .|..|. 
rsdyinaseilpglylgslpp......addlellkelgithivnlteelelgflk.........cdpywpeeagiqylhipipDhgvpdllehflefvef

IDFS--CLNGRIAIHCHAGLGRTGSVIACYLVYSQRIGAEEAITKVRDKRPdSIQSRSQIELVVQFSLFLLSL
|.      .|....||.||.||.|...|.||...... .||||  || .||  .....|.. . .| |.||. 
ieealdekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllke
0036282 (Phosphotyrosine protein) phosphatases II 122-280 1.6e-30 101.4 In-house 13-168 (174) alignment 
Range on Protein: 122-280
Range on HMM: 13-168/174.0
HWVTDNILAMARPSTqlftqykLLDQFKESGINAVINLQTAGEHAHCGPPQENSGftyKPEDLMRQNIYYYNYPLPDYSTFSVENMLDVVKVIDFSCLN-
...|....|.. | .        ....|| ||..|..| .  |  ... ..  .    ..||| | .| |. .| ||....... .|..|| ..  ... 
syitprliagqgpla.......fwemlkelgittvvmlleekelglykcinywpe...lredlerlgiqylylpwpDhgvpdlsillefvkfveealsed

--GRIAIHCHAGLGRTGSVIACYLVYSQRI-GAEEAITKVRDKR---PDSIQSRSQIELVVQFSLF
  | ...||.||.|||| ..|.||.. . . ....|.  || .|   | ..|. ||.. . .|. .
pggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekl
0042113 (Phosphotyrosine protein) phosphatases II 122-282 3e-28 94.3 In-house 48-243 (245) alignment 
Range on Protein: 122-282
Range on HMM: 48-243/245.0
HWVTDNILAMARPSTQlfTQYKLLDQFKESGINAVINLQTAGEHAHCGPPQEN--------SG--------------------FTYKPEDLMRQNIYYYN
...|....|.. |...  |  . . ...| ||.....| .  |. ... .|           .                     |....|  |..| |. 
yritpkfiatqgPlpe..tvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhy

YPLPDYSTFS-VENMLDVVKVIDFSCL---NGRIAIHCHAGLGRTGSVIACYLV-----YSQRIGAEEAITKVRDKRPDSIQSRSQIELVVQFSLFLL
.| ||... . .| .||... ..  .    ||....||.||.|||| .||.||.     . ... .|||. ..|..|| ..|. ||.. . .. |.||
lpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
0037934 (Phosphotyrosine protein) phosphatases II 122-281 6.6e-28 93.3 In-house 40-241 (243) alignment 
Range on Protein: 122-281
Range on HMM: 40-241/243.0
HWVTDNILAMARPSTQLFTQ--YKLLDQFKESGINAVINLQTAGEHAHCGPPQENSG---------------------------FTYKPEDLMRQNIYYY
..||... |.  | .. . .  .. .. ..| ||.....| .  |. ... .|  .|                             ....|| |..| |.
iyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyh

NYPLPDYSTFS-VENMLDVVKVID----------FSCLNGRIAIHCHAGLGRTGSVIACYLVYSQ-RIGAEEAITKVRDKRPD-SIQSRSQIELVVQFSL
 .| ||... . .|..|| .. .               .|....||.||.|||| .||.||.... ....|||. ..|..||  ..|..||.. . .. |
ylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeall

FL
.|
el
0048076 (Phosphotyrosine protein) phosphatases II 145-281 1.7e-27 91.2 In-house 22-142 (145) alignment 
Range on Protein: 145-281
Range on HMM: 22-142/145.0
LDQFKESGINAVINLqtagehahcgppqensgfTYKPEDLMRQNIYYYNYPLPDYSTFSV-ENMLDVVKVIDFSCL-NGRIAIHCHAGLGRTGSVIACYL
|...|. || .|.||                  |. .|.| |..| |...|.||.....  | .|.... |.     .|....||.||.||||...|.||
lellkdlgittvlnl..................tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaayl

VYSQRIGAEEAITKVRDKRPDSIQSRSQIELVVQFSLFL
...... .|||. .|| .|| .... .|.. . .| | |
mlllgvsleealelvrsqrpgavpnpgqlrflyefelel
0049260 (Phosphotyrosine protein) phosphatases II 143-278 4.4e-27 90.1 In-house 24-146 (152) alignment 
Range on Protein: 143-278
Range on HMM: 24-146/152.0
KLLDQFKESGINAVINLQTAGEHAHCGPPQENsgftykpedlmrqniYYYNYPLPDYSTFSVENMLDVVKVID---FSCLNGRIAIHCHAGLGRTGSVIA
. ....|| ||.....| .  | .... .|                  |...| ||... . . .|. .  ..       .|....||.||.|||| ..|
dfwrmlkelgittivmltellelgklkceqyi...............qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlva

CYLVYsQRIGAEEAITKVRDKRPDSIQSRSQIELVVQFS
.||.. ... .|||.  || ||| .... .|.... .|.
aylml.lgvsleeavalvrekRpgavpnpgqlrflyefe
0039614 (Phosphotyrosine protein) phosphatases II 120-283 5e-27 90.6 In-house 84-290 (297) alignment 
Range on Protein: 120-283
Range on HMM: 84-290/297.0
YSHWV-----------TDNILAMARPSTQlfTQYKLLDQFKESGINAVINLQTAGEHAH-------------------CGPPQENSGFT-----YKPEDL
 | ..           |....|.  |...  | .. .  ..| |......| .  |. .                   .   ....|.|      .... 
dsdYinAsyvdgydlltrkfIatqgPlpe..tvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnnge

MRQNIYYYNYPLPDYSTF-SVENMLDVVKVIDFSC----LNGRIAIHCHAGLGRTGSVIACYLV-----YSQRIGAEEAITKVRDKRPDSIQSRSQIELV
 |.   .  .. ||...  |.| .|.... ..  .     .|....||.||.||||..||.||.     . ... ..||. ..| .|| ..|. ||.. .
srtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrfl

VQFSLFLLS
 .. |.||.
ydallellk
0045098 (Phosphotyrosine protein) phosphatases II 141-283 8.2e-27 89.7 In-house 77-273 (278) alignment 
Range on Protein: 141-283
Range on HMM: 77-273/278.0
QYKLLDQFKESGINAVINLQTAGEHA--HCGPPQENSG-----------------------------FTYKPEDLMRQNIYYYNY-PLPDYSTFSVE---
  . .....| ||.....| .  | .  .| ..  ..|                             .|...|||.  ......| | ||... | .   
vadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilk

NMLDVVKVIDFSC---------------LNGRIAIHCHAGLGRTGSVIACYLVYSQ---RIGAEEAITKVRDKRPD-SIQSRSQIELVVQFSLFLLS
 .|.... |.  .                .|....||.||.|||| ..|.||....   .. ..||....| .||  ..|. .|.. . .| | ||.
sflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelll
0040439 (Phosphotyrosine protein) phosphatases II 122-281 9.8e-27 89.6 In-house 50-245 (249) alignment 
Range on Protein: 122-281
Range on HMM: 50-245/249.0
HWVTDNILAMARPSTQlfTQYKLLDQFKESGINAVINLQTAGEH--AHCGPPQENSGFT----------------------------YKPEDLMRQNIYY
 .......|.  | ..  | .. .....| ||.....| .  |.   .| .   ..|..                            |..|... . |.|
yyikrrfiatqgPlpe..tvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqy

YNYPlpDYSTF-SVENMLDVVKVIDFSC----LNGRIAIHCHAGLGRTGSVIACYLV-----YSQRIGAEEAITKVRDKRPDSIQSRSQIELVVQFSLFL
.. |  |...  |.| .|| .. ..  .     .|....||.||.|||| .||.||.     . ... .|||. ..|..|| ..|. .|.. . .. |.|
tdwp..dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
0048179 (Phosphotyrosine protein) phosphatases II 145-277 4.6e-26 86.7 In-house 22-140 (144) alignment 
Range on Protein: 145-277
Range on HMM: 22-140/144.0
LDQFKESGINAVINLQTAGEHAHCGPPqensgftykpedlmrqNIYYYNYPLPDYSTFSV-ENMLDVVKVIDFSCL-NGRIAIHCHAGLGRTGSVIACYL
|...|. ||..||||..  |.......                .| |...|.||.....  | .|.... |.     .|....||.||.||||...|.||
lellkklgittvinlteeyepeflere................giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaayl

VYSQRIGAEEAITKVRDKRPDSIQSRSQIELVVQF
.. ... .|||.  || .|| ......|.. . ..
mkklglsleealalvrsrrpgavpnpgqlrfLley
0045450 (Phosphotyrosine protein) phosphatases II 122-281 2.4e-25 85.3 In-house 103-303 (307) alignment 
Range on Protein: 122-281
Range on HMM: 103-303/307.0
HWVTDNILAMARPSTQlfTQYKLLDQFKESGINAVINLQTAGEHAH----CGPPQENSGFTYK--------------------------PEDLMRQNIYY
........|.  |  .  | .. . ...| |......| .  |...       |.|.. .||.                          ...  |. ...
ydlkrkfIatqgPlpe..tvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthf

YNYPLPDYSTF-SVENMLDVVKVIDFSC----LNGRIAIHCHAGLGRTGSVIACYLVYSQR--------IGAEEAITKVRDKRPDSIQSRSQIELVVQFS
. .  ||...  |.| .|| .. ..  .     .|....||.||.||||..||.||...|.        . ..||. ..|..|| ..|. .|.. . .. 
hytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeal

LFL
|.|
lel
0043336 (Phosphotyrosine protein) phosphatases II 122-281 3e-25 84.6 In-house 84-276 (278) alignment 
Range on Protein: 122-281
Range on HMM: 84-276/278.0
HWVTDNILAMARPSTQlfTQYKLLDQFKESGINAVINLQTAGEHAH--------------------CGPPQENSGFT---------YKPEDlmRQNIYYY
..|.....|.  |...  | ..    ..| |.. ...| .  |. .                    .   ......|         ...|   |.   |.
ynvprkfiatqgPlpe..tvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdges..rtvthyh

NYPLPDYSTF-SVENMLDVVKVIDFSC--LNGRIAIHCHAGLGRTGSVIACYLV-----YSQRIGAEEAITKVRDKRPDSIQSRSQIELVVQFSLFL
 .. ||...  |.. .|| .|...  .   || ...||.||.|||| .||.||.     . ... .|||. ..| .|| ..|. ||.. . .. |..
ylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
0051082 (Phosphotyrosine protein) phosphatases II 122-274 1e-24 82.3 In-house 9-145 (151) alignment 
Range on Protein: 122-274
Range on HMM: 9-145/151.0
HWVTDNILAMARPSTqlftqyKLLDQFKESGINAVINLQTAGEHAHCGPPQENSGftykpedlmrqnIYYYNYPLPDYSTFSV----ENMLDVVKVIDFs
..||....... |.         |...|| ||....|| .  |...|  . .. |            | ....|..| .....    . .|.......  
syvtgglyrsggpla......dflellkelgiktivnlrseeergycpeylpelg............ievlhipildwpdpglplsfdavleflellld.

CLNGRIAIHCHAGLGRTGSVIACYLVYsQRIGAEEAITKVRDKRPDSIQSRSQIELV
. || ...||.||.|||| ..|.||.. ... .|||.  .| ||| ..|.  |. ..
kkngpvlvHCsaGkgRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfq
0040438 (Phosphotyrosine protein) phosphatases II 123-291 2.1e-24 81.8 In-house 83-285 (317) alignment 
Range on Protein: 123-291
Range on HMM: 83-285/317.0
WVTDNILAMARPSTQlfTQYKLLDQFKESGINAVINLQTAGEHA---------------------HCGPPQEnsgftykpedlmRQNIYYYNYPL-----
. .....|.  |  .  | .. .  ..| |.. ...| .  |                       ..   .|             ..| ... ..     
nlkrkfIatqgPlpn..tvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee............lagitlrtlevedlgd

--------------PDYSTF-SVENMLDVVKVIDFS--CLNGRIAIHCHAGLGRTGSVIACYLV-----YSQRIGAEEAITKVRDKRPDSIQSRSQIELV
              ||...  | . .|| .. .. .    .| ...||.||.||||..||.||.     . ... .|||. ..| .|| ..|. .|.. .
sesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrfl

VQFSLFLLSLWNLYPTL
 .. |..|   . .. .
ydalleylkrkltlepa
0049772 (Phosphotyrosine protein) phosphatases II 157-279 1.4e-23 79.5 In-house 167-277 (314) alignment 
Range on Protein: 157-279
Range on HMM: 167-277/314.0
InlqtagehahcgppqensGFTYKPEDLMRQNIYYYNYPLPDYSTFSVENMLDVVKVIDFSCLNGRIAIHCHAGLGRTGS-VIACYLVYSQRIGAEEAIT
                   . .| ||.. |..| |...|.||.|. . | .......|.    .|....||.|| ||||. |.|.||.. ... .|||. 
k..................eelydpelferlgikylripvpDgsaplledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleeale

KVRDKRP-----DSIQSRSQIELVVQFSL
 || |||      .|..  | | . ...|
dvrlkRpinpnpgfieqleqyefileall
0051429 (Phosphotyrosine protein) phosphatases II 121-281 6.2e-23 77.3 In-house 16-224 (272) alignment 
Range on Protein: 121-281
Range on HMM: 16-224/272.0
SHWVTDN-ILAMARPSTQLFTQYKLLdqfKESGINAVINLQTAGEHAHCGPPQENsgftykpedlmrQNIYYYNYPLPDYSTFSV---------------
 ..| .. ......|..    ... |   || ||.....| .  |..... ...             ..| |...|..|.|....               
grvvkpgrlyrsggplpltaadfwrl...kelgiktivdLrseeErgrlkcdryw............pgirylhlpilddsaptilygalrvtllseell

-------------------------------------ENMLDVVKVIDFsclNGRIAIHCHAGLGRTGSVIACYLVYsQRIG--------------AEEA
                                     | .|......     .|.. .||.|| .||| |.|..|.. ....              .|||
ldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld...ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleea

ITKVRDKRPDSIQSRSQIELVVQFSLFL
. ..|..|| ..|.  |.. . .. | |
veelraqrpgavqteeqylflyeallel
0046845 (Phosphotyrosine protein) phosphatases II 182-285 7.9e-21 70.1 In-house 161-277 (284) alignment 
Range on Protein: 182-285
Range on HMM: 161-277/284.0
EDLMRQNIYYYNYPLPDYSTF-SVENMLDVVKVIDFS----CLNGRIAIHCHAGLGRTGSVIACYLVYSQ--------RIGAEEAITKVRDKRPDSIQSR
..  |. ....  . ||...  |.|..|. .. .. .      .| |..||.||.|||| .||..|...|        .. ..||. ..|..|| ..|. 
tgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtl

SQIELVVQFSLFLLSLW
.|...| .. |..|.|.
eqyrfvyealleylklk
0047943 (Phosphotyrosine protein) phosphatases II 181-279 1.3e-19 66.2 In-house 161-269 (273) alignment 
Range on Protein: 181-279
Range on HMM: 161-269/273.0
PEDLMRQNIYYYNYPLPDYSTF-SVENMLDVVKVIDFSCL----NGRIAIHCHAGLGRTGSVIACYLV-----YSQRIGAEEAITKVRDKRPDSIQSRSQ
  .  |. .... .. ||...  |.| .|. .....  .     || ...||.||.||||..||..|.     . ... ..||. ..|..|| ..|. .|
gtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeq

IELVVQFSL
.... .. |
yrflyeall
0050432 (Phosphotyrosine protein) phosphatases II 184-284 4.3e-19 64.4 In-house 195-301 (308) alignment 
Range on Protein: 184-284
Range on HMM: 195-301/308.0
LMRQNIYYYNYPLPDYSTFS-VENMLDVVKVIDFSCLNGRIAIHCHAGLGRTGSVIACYLV-----YSQRIGAEEAITKVRDKRPDSIQSRSQIELVVQF
 .|.   ..    ||... . .| .|| .. .. |. .| |..||.||.|||| .||..|.     . ... ..||. |.| .|| ..|. .| ... . 
esrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyra

SLFLLSL
 |..|.|
lleylkl
subfamily_DSP23_pd Subfamily DSP23 123-281 5.6e-19 63.2 In-house 7-145 (148) alignment 
Range on Protein: 123-281
Range on HMM: 7-145/148.0
WVTDNILAMARPSTQLFTQYklLdqfKESGINAVINLQTagehaHCGPPQENSgftykPedlmrqNIYYYNYPLPDYSTFSVENMLDVVKVIDFSC-LNG
||. .. |.| |..    .|  |    . |.  .. | .     .. |. | .     |      |. ...  ..||   ..|.. . |.|.. .   | 
wvssrlaalalprlpdqyry..l...ldlgvrylvslte.....egrphveat.....p......nltlvrlriddyhppaleqvvefvrvveeaeekne

RIAIHCHAGLGRTGSVIACYLVYSQRIGAEEAITKVRDKRPDSIQSRSQIELVVQFSLFL
 ...||  | ||||...|||||  ... | |||..|| .|| |...  | .|| ..  |.
avsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsvetveqeklvrdyetfi
0036941 (Phosphotyrosine protein) phosphatases II 187-288 1.1e-18 63.0 In-house 142-283 (297) alignment 
Range on Protein: 187-288
Range on HMM: 142-283/297.0
QNIYY--------------------------YN-YPLPDYSTFS-VENMLDVVKVIDFSC----LNGRIAIHCHAGLGRTGSVIACYLV--------YSQ
.....                          .     ||... . .. .|| .. ..  .     .|.. .||.||.||.|..||..|.        . .
lsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeg

RIGAEEAITKVRDKRPDSIQSRSQIELVVQFSLFLLSLWNLY
..   ||. |.|..|| ..|. .| . . .. |.||   ...
gvdileavkklReqRpgavqtleqyrflyeallellkkkltk
subfamily_CDC14_pd Subfamily CDC14 124-272 2.7e-18 60.9 In-house 176-315 (328) alignment 
Range on Protein: 124-272
Range on HMM: 176-315/328.0
VTDNILAMARPSTQ--LFTQY------KLLDQFKESGINAVINLQTAgehahcgppqensgfTYKPEDLMRQNIYYYNYPLPDYSTFSVENMLDVVKVID
| | .||.| | ..  |  .|      |||. |.. ....|. |                   |. .    . . ...    | || | . .   .....
vPdkflalagPhnkskledgyplhaPeklleyfrknnvttvvrLnkk...............lYdakkftdaGfdhkDlffiDGstPsdaivkkfleiae

FSclNGRIAIHCHAGLGRTGSVIACYLVYSQRIGAEEAITKVRDKRPDSIQSRSQIE
 .  .| ||.||.|||||||..|||||..  |. |.|||. .|  || |. .  |  
ka..eGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGsvigpqqkf
0051299 (Phosphotyrosine protein) phosphatases II 181-276 7.2e-18 60.5 In-house 177-280 (288) alignment 
Range on Protein: 181-276
Range on HMM: 177-280/288.0
PEDLMRQNIYYYNYPLPDYSTFS-VENMLDVVKVIDFS--CLNGRIAIHCHAGLGRTGSVIACYLV-----YSQRIGAEEAITKVRDKRPDSIQSRSQIE
...  |. . .. .  ||... . .| .|| .. .. .    .| ...||.||.|||| .||..|.     . ... ..||. ..| .|| ..|. .|..
gdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyr

LVVQ
.| .
fvye
subfamily_PTPMT1_pd Subfamily PTPMT1 180-281 1.5e-16 55.3 In-house 72-168 (171) alignment 
Range on Protein: 180-281
Range on HMM: 72-168/171.0
KpedlmrqNIYYYNYPLPDYS-TFSVENMLDVVKVIDFSCLNG-RIAIHCHAGLGRTGSVIACYLVYSQRIGAEEAITKVRDKRPDSIQSRSQIELVVQF
        .. ..... .|.  . ..|.... |..|.    .| |. .||.|| ||.....||||......  |||.. ...||.     . | ... ..
l.......gveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqey

SLFL
  .|
eekl
0048567 (Phosphotyrosine protein) phosphatases II 185-283 1.7e-16 54.9 In-house 16-140 (157) alignment 
Range on Protein: 185-283
Range on HMM: 16-140/157.0
MRQNIYYYNYPLPDYSTFSVENML------------DVVKVIDF-----------SCLNGRIAIHCHAGL---GRTGSVIACYLVYSQRIGAEEAITKVR
.  . ....  |...  ||... |            ..  ...|           .  ...||.||.|||   |||. .|.|||.. ... .||||  .|
yfallprlpkslynalyFsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplr

DKRPDSIQSRSQIELVVQFSLFLLS
  ||.|.  | .  |.  ..| || 
ivrpgsvpfrdasyllslynltlld
DSPc Dual specificity phosphatase, catalytic domain 145-271 4.6e-15 50.7 Pfam-A 11-124 (133) alignment 
Range on Protein: 145-271
Range on HMM: 11-124/133.0
LDQFKESGINAVINLQTAGEHAhcgppqensgftykpEDLMRQNIYYYNYPLPDY-STFSVENMLDVVKVID-FSCLNGRIAIHCHAGLGRTGSVIACYL
|.. .. ||..|||...  ...                .   ..| | ..|. |  .|  .. . ..|..|. .   ......|| ||. |....|..||
lalleklgitlvinvtkevpnn...............naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYl

VYSQRIGAEEAITKVRDKRPDSIQSRSQI
 ..... ..||.  |...|.   .. ...
mktknlslneAyefvkerrskispnagfl
DSPc Dual specificity phosphatase, catalytic domain 145-271 4.6e-15 50.7 In-house 11-124 (133) alignment 
Range on Protein: 145-271
Range on HMM: 11-124/133.0
LDQFKESGINAVINLQTAGEHAhcgppqensgftykpEDLMRQNIYYYNYPLPDY-STFSVENMLDVVKVID-FSCLNGRIAIHCHAGLGRTGSVIACYL
|.. .. ||..|||...  ...                .   ..| | ..|. |  .|  .. . ..|..|. .   ......|| ||. |....|..||
lalleklgitlvinvtkevpnn...............naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYl

VYSQRIGAEEAITKVRDKRPDSIQSRSQI
 ..... ..||.  |...|.   .. ...
mktknlslneAyefvkerrskispnagfl
PTPc_motif_SM00404 146-268 7.8e-14 46.7 In-house 21-127 (140) alignment 
Range on Protein: 146-268
Range on HMM: 21-127/140.0
DQFKESGINAVINLQTAGEHAhcgppqensgftykpedLMRQNIYYYNYPLPD-YSTFSVENMLDVVKVIDFSCLNG-RIAIHCHAGLGRTGSVIACYLV
.. |. || .|||...  .                      ... . ..|| |  ..  .. .  |...|. .  .| .. .|| ||. |....|..|| 
allkklgithvinvteevslt.................kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlm

YSQRIGAEEAITKVRDKRpDSIQSR
... . ..||.  |...| ..|. .
ryrqlslaeayefvkerR.piispn
subfamily_PTEN_pd Subfamily PTEN 110-271 4.5e-11 38.1 In-house 14-169 (184) alignment 
Range on Protein: 110-271
Range on HMM: 14-169/184.0
EETGVAFDglySHWVTDNILAMARPSTQLFTQYK--------LLDQFKeSGINAVINLQTAGehahcgppqensgfTYKPEDLmRQNIYYYnyPLPDYST
.| |.  |     ..|.||.||. |...| . |.        .|.. . ..   ..||..                .|. ... ....  |  |. |  .
kedgldLD...lsyiteniiamgyPaeklealyRnsledvvkflekkh.kdhykiynlrser..............kydskkf.dgrvavy..pfdDhnp

FSVENMLDVVKVIDFSC---LNGRIAIHCHAGLGRTGSVIACYLVYSQRIGAE-EAI---TKVRDKRPDSIQSRSQI
 ..| . ..|. |.       .  ...||.|| |||| .|..||..|. .  . ||.   ...| |   ...  ||.
pplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvtiPsqr
subfamily_CDKN3_pd Subfamily CDKN3 189-277 4.9e-11 36.6 In-house 100-191 (202) alignment 
Range on Protein: 189-277
Range on HMM: 100-191/202.0
IYYYNYPLPDYSTFSVENMLDVVKVIDFSCLNGR-IAIHCHAGLGRTGSVIACYLVY-SQRIGAEEAITKVRDKRP-DSIQSRSQIELVVQF
.  . ||..|  . .. . |.... .  .  ..|   .||. ||||.  |||| |.| .. |  ..|| |.|| .   .||.  | . . .|
livhhypiadglvpdiasclkileelrinlkayrktlvhcygglgrsslviaclllylddtiepkdaidklrdlkgsraiqtvkqynylsef
PTPc_DSPc_SM00012 205-275 1.5e-10 36.5 In-house 20-100 (105) alignment 
Range on Protein: 205-275
Range on HMM: 20-100/105.0
ENMLDVVKVIDFSCL----NGRIAIHCHAGLGRTGSVIACYLVYSQ------RIGAEEAITKVRDKRPDSIQSRSQIELVV
...|.... .. .      .. . .||.|| |||| ..| .....|      ..  .. . ..|..|| ..|.  |   . 
dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly
subfamily_DSP3_pd Subfamily DSP3 187-261 6.3e-10 32.9 In-house 61-138 (162) alignment 
Range on Protein: 187-261
Range on HMM: 61-138/162.0
QNIYYYNYPLPDYSTFSVENMLD-VVKVIDFSCL--NGRIAIHCHAGLGRTGSVIACYLVYSQRIGAEEAITKVRDKR
 .| |.  .. |  .| ...  . ..| || .    .|.. .||..|. |   ..  ||. .... . |||..||.||
leikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkR
subfamily_RNGTT_pd Subfamily RNGTT 208-268 7.4e-10 32.8 In-house 101-161 (189) alignment 
Range on Protein: 208-268
Range on HMM: 101-161/189.0
LDVVKVIDFSCLNGRIAIHCHAGLGRTGSVIACYLVYSQRIGAEEAITKVRDKRPDSIQSR
  .|.       .  |..||. |  ||| .|..|||  . ...|.|..  .  ||  |   
iklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiyke
subfamily_DSP1_pd Subfamily DSP1 186-262 8e-10 33.0 In-house 59-137 (163) alignment 
Range on Protein: 186-262
Range on HMM: 59-137/163.0
RQNIYYYNYPLPDYSTFSVENML-DVVKVIDF-SCLNGRIAIHCHAGLGRTGSVIACYLVYSQRIGAEEAITKVRDKRP
..   |.. .| | ..  .  .. .|.. ||     ||.. |||.||. |  ...  ||. ..|.  ||| . |...|.
edlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRs
DSPc_SM00195 197-281 1.5e-09 32.9 In-house 169-261 (263) alignment 
Range on Protein: 197-281
Range on HMM: 169-261/263.0
PDYSTF-SVENMLDVVKVIDFSCL--NGRIAIHCHAGLGRTGSVIACYLVYSQR-----IGAEEAITKVRDKRPDSIQSRSQIELVVQFSLFL
|| ..  | ...|....... |    .| | .||.||.||||....  ...|.      .  .| ....|..|| ..|.. |   ...  |..
pdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 197-281 1.5e-09 32.9 In-house 169-261 (263) alignment 
Range on Protein: 197-281
Range on HMM: 169-261/263.0
PDYSTF-SVENMLDVVKVIDFSCL--NGRIAIHCHAGLGRTGSVIACYLVYSQR-----IGAEEAITKVRDKRPDSIQSRSQIELVVQFSLFL
|| ..  | ...|....... |    .| | .||.||.||||....  ...|.      .  .| ....|..|| ..|.. |   ...  |..
pdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
subfamily_DSP12_pd Subfamily DSP12 219-263 2.9e-09 31.5 In-house 79-125 (155) alignment 
Range on Protein: 219-263
Range on HMM: 79-125/155.0
L--NGRIAIHCHAGLGRTGSVIACYLVYSQRIGAEEAITKVRDKRPD
|  .| . .||.||. |  .... ||......  |.|. .|..|.|.
leeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkpe
subfamily_DSP19_pd Subfamily DSP19 212-262 4.6e-09 30.8 In-house 80-131 (152) alignment 
Range on Protein: 212-262
Range on HMM: 80-131/152.0
KVIDFSC-LNGRIAIHCHAGLGRTGSVIACYLVYSQRIGAEEAITKVRDKRP
. |. .   .|.. .||.||  |. ||.  ||. ....  |||...||..||
dFieearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearp
subfamily_Laforin_pd Subfamily Laforin 147-262 5.5e-09 29.2 In-house 32-152 (183) alignment 
Range on Protein: 147-262
Range on HMM: 32-152/183.0
QFKESGINAVINLQTAGEHA-HC-GPPQENSGFTYKPEDLMRQ-NIYYYNYPLPDYSTFSVENML-DVVKVIDFSCLNG-RIAIHCHAGLGRTGSVIACY
..|. || |||.|||. .   .. |  . |  .      | ..  . |   |..| || |  ..| . | ..     .| .. .|| ||.||. ...  .
dlksegitavislqtesdivknssgiyrynenlpitlkklykeeglayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgf

LVYSQRIGAEEAITKVRDKRP
| |            .  |||
lqyvlgwslakvqyfllakrp
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 214-278 8.9e-09 29.5 In-house 213-283 (305) alignment 
Range on Protein: 214-278
Range on HMM: 213-283/305.0
IDFSCLNGRIAIHCHAGLGRTGSVIACYLVYSQR-----IG-AEEAITKVRDKRPDSIQSRSQIELVVQFS
..   . | |..|| ||.||||||.    .  |      |  ..  . |.|..| .|||.  |  .| |  
ekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvi
Y_phosphatase Protein-tyrosine phosphatase 202-276 1.4e-08 29.8 Pfam-A 150-231 (235) alignment 
Range on Protein: 202-276
Range on HMM: 150-231/235.0
FSVENMLDVVKVIDFSC--LNGRIAIHCHAGLGRTGSVIACYLVYSQRIG-----AEEAITKVRDKRPDSIQSRSQIELVVQ
 |....||... .  |    .| . .|| || ||||...|  .. .|          ... ..| .|| ..|| .| . ...
espkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflyk
Y_phosphatase Protein-tyrosine phosphatase 202-276 1.4e-08 29.8 In-house 150-231 (235) alignment 
Range on Protein: 202-276
Range on HMM: 150-231/235.0
FSVENMLDVVKVIDFSC--LNGRIAIHCHAGLGRTGSVIACYLVYSQRIG-----AEEAITKVRDKRPDSIQSRSQIELVVQ
 |....||... .  |    .| . .|| || ||||...|  .. .|          ... ..| .|| ..|| .| . ...
espkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflyk
subfamily_PRL_pd Subfamily PRL 178-272 2.1e-08 28.3 In-house 45-140 (151) alignment 
Range on Protein: 178-272
Range on HMM: 45-140/151.0
TYKPEDLMRQNIYYYNYPLPDYSTFS---VENMLDVVKVIDFSCLNGRIAIHCHAGLGRTGSVIACYLVySQRIGAEEAITKVRDKRPDSIQSRsQIE
||. | | ...|   .... | .. .   ||. |...|       .  .|.|| |||||.  ..|  |.  . .  |.|.  .|.|| ..| |. |..
tydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalali.eaGmkyedavefirekrrgainsk.qlk
subfamily_DSP8_pd Subfamily DSP8 217-266 7.4e-08 26.1 In-house 90-138 (159) alignment 
Range on Protein: 217-266
Range on HMM: 90-138/159.0
SCLNGRIAIHCHAGLGRTGSVIACYLVYSQRIGAEEAITKVRDKRpDSIQ
   |||. .|..||  |  .|. .|..   ... .|| . |..||  .|.
ksengrvlvhvlaGisrsatvaiayimktlemsldeayrfvkekr.ptis
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 196-276 9.3e-08 26.6 In-house 152-236 (250) alignment 
Range on Protein: 196-276
Range on HMM: 152-236/250.0
LPDYSTfSVENMLDVVKVIDFSCLNGRIAIHCHAGLGRTGSVIACYLV-----YSQRIGAEEAITKVRDKRPDSIQSRSQIELVVQ
 |.. | .| ..|. |.  .  . |. . ..| || ||.|. || . |      .. .   . | ..| .||....|..|   | .
vPevat.avLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvye
subfamily_DSP10_pd Subfamily DSP10 184-262 2.4e-07 24.8 In-house 54-134 (159) alignment 
Range on Protein: 184-262
Range on HMM: 54-134/159.0
LMRQNIYYYNYPLPDYSTFSVENMLDV-VKVID-FSCLNGRIAIHCHAGLGRTGSVIACYLVYSQRIGAEEAITKVRDKRP
   ... |   |. | |.  ...  .. .. |.     . |. .||.||. |  .|.  ||.. ...  ..|   |..|||
feeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekrp
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 203-276 2.5e-07 25.1 In-house 196-274 (318) alignment 
Range on Protein: 203-276
Range on HMM: 196-274/318.0
SVENMLDVVKVIDFSCLNGRIAIHCHAGLGRTGSVIACYlVYSQRIGAEEA------ITKVRDKRPDSIQSRSQIELVVQ
|. ...  |. .. .. .| |..|| || ||||  ||   .  .|| ||.       ....|..|.  .| ..| |.. .
slldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavd.illerikaealvDvfqtvkqlreqrnlmvqtedqyefiyd
subfamily_PTPN12_pd Subfamily PTPN12 191-276 3.5e-07 24.4 In-house 174-271 (290) alignment 
Range on Protein: 191-276
Range on HMM: 174-271/290.0
YYNYP-LPDYST-FSVENMLDVVKVIDFSCL--NGRIAIHCHAGLGRTGSVIACYLVYSQRI--------GAEEAITKVRDKRPDSIQSRSQIELVVQ
 ..|   ||  .  |....|.... .       .  ...|| || |||| .||  .|...             . ....| .|.  .|.. | ||| .
qfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvyk
CDKN3 Cyclin-dependent kinase inhibitor 3 (CDKN3) 183-254 5.5e-07 20.9 Pfam-A 94-168 (168) alignment 
Range on Protein: 183-254
Range on HMM: 94-168/168.0
DLMRQ-NIYYYNYPLPDYSTFSVENMLDVVKVIDFSCLNGR-IAIHCHAGLGRTGSVIACYLVY-SQRIGAEEAI
|| .|  |  . .|..|  |  .   |.... .     | |   |||. ||||.  | || |.| |. |  |.||
dlyqqygivthhhpiadggtpdiascleimeelatclknyrktlihcygglgrsclvaaclllylsdsispeqai
CDKN3 Cyclin-dependent kinase inhibitor 3 (CDKN3) 183-254 5.5e-07 20.9 In-house 94-168 (168) alignment 
Range on Protein: 183-254
Range on HMM: 94-168/168.0
DLMRQ-NIYYYNYPLPDYSTFSVENMLDVVKVIDFSCLNGR-IAIHCHAGLGRTGSVIACYLVY-SQRIGAEEAI
|| .|  |  . .|..|  |  .   |.... .     | |   |||. ||||.  | || |.| |. |  |.||
dlyqqygivthhhpiadggtpdiascleimeelatclknyrktlihcygglgrsclvaaclllylsdsispeqai
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 202-276 6e-07 24.0 In-house 205-284 (298) alignment 
Range on Protein: 202-276
Range on HMM: 205-284/298.0
FSVENMLDVVKVIDFSCLNGRIAIHCHAGLGRTGSVIACYLVY-----SQRIGAEEAITKVRDKRPDSIQSRSQIELVVQ
 || ..|. |.     . |  . ..| || ||.|. || . |      .| .   ...  .| ||| ..|...|   . .
tsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiye
subfamily_DSP11_pd Subfamily DSP11 220-267 7.1e-07 23.3 In-house 116-163 (178) alignment 
Range on Protein: 220-267
Range on HMM: 116-163/178.0
NGRIAIHCHAGLGRTGSVIACYLVYSQRIGAEEAITKVRDKRPDSIQS
.  |..||  |. ||| .|  ||.  . . .|.|| .  . |  |.. 
dkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhsler
subfamily_PTPN13_pd Subfamily PTPN13 197-282 8.5e-07 23.5 In-house 177-269 (273) alignment 
Range on Protein: 197-282
Range on HMM: 177-269/273.0
PDYSTFS-VENMLDVVK-VIDFSCLNGRIAIHCHAGLGRTGSVIACYLVY-----SQRIGAEEAITKVRDKRPDSIQSRSQIELVVQFSLFLL
||... |  ...| .|. |  .   .| |..|| ||.||.|..|. . |       . .  .| . |.|..|   .|.. |  .| .  | .|
PdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_DSP15_pd Subfamily DSP15 149-262 1.1e-06 22.8 In-house 24-120 (151) alignment 
Range on Protein: 149-262
Range on HMM: 24-120/151.0
KESGINAVINLQTagehahcgppqensgftykPEDLMRQNIYYYNYPLPDYSTFSVENMLD-VVKVIDFSCLNG-RIAIHCHAGLGRTGSVIACYLVYSQ
||  |  .....                     .  ....| |  ... | .   ......  |..|  . |..  . .|| ||. |   ... ||.   
keknithilsvhd...................nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtvt

RIGAEEAITKVRDKRP
 .. ..|.. .. .| 
elnwrdalevikaaRs
subfamily_PTPRA_pd Subfamily PTPRA 207-277 1.2e-06 22.6 In-house 213-290 (330) alignment 
Range on Protein: 207-277
Range on HMM: 213-290/330.0
M---LDVVKVIDFSCLNgRIAIHCHAGLGRTGSVIACYLVY-----SQRIGAEEAITKVRDKRPDSIQSRSQIELVVQF
|   |  || ..    .  | .|| || ||||. |.   |       ...   |.. ..| .||. .|.  | |.. . 
mlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykv
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 220-274 1.2e-06 22.9 In-house 221-280 (325) alignment 
Range on Protein: 220-274
Range on HMM: 221-280/325.0
NGRIAIHCHAGLGRTGSVIACYLVYSQRIG-----AEEAITKVRDKRPDSIQSRSQIELV
 . | .|| ||.||||  |. | .  . |        . . |.| .||. ...  |  |.
stpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyili
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 207-276 1.3e-06 22.6 In-house 183-258 (270) alignment 
Range on Protein: 207-276
Range on HMM: 183-258/270.0
MLDVVKVIDFSCLNG-RIAIHCHAGLGRTGSVIA-----CYLVYSQRIGAEEAITKVRDKRPDSIQSRSQIELVVQ
||  |.    .  ..  . .|| ||.|||| .||     . |  ....   . |...| .|.. .|   |.|.. .
mlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflyk
subfamily_DSP6_pd Subfamily DSP6 187-263 2.4e-06 21.2 In-house 58-136 (158) alignment 
Range on Protein: 187-263
Range on HMM: 58-136/158.0
QNIYYYNYPLPDYSTFSVENML-DVVKVIDFSCLN-GRIAIHCHAGLGRTGSVIACYLVYSQRIGAEEAITKVRDKRPD
... |.. |. |  .  . ... . .. || .  .   . .||.||. |.  |. .||. .. .  ..|   |......
gelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlaylmkklalslndaydlvkkrksn
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 147-280 2.9e-06 20.9 In-house 110-234 (392) alignment 
Range on Protein: 147-280
Range on HMM: 110-234/392.0
QFKESGINAVINLQTAGehahcgppqensgftyKPEDLMRQNIY-YYNYPLPD--YSTFSVENMLDVVKViDFSCLNGRIAIHCHAGLGRTGSVIACYLV
|.. . |  | .|. .                 | .|      . . ..|  |    | |. ...  ||. ||      . ||| ||.|||| ||.   |
qenvttiamvtklkegd................kgddartvaqfhftewPdkdvpkhtssllkfikevka.dfGqythpliihcsagvgrtgvvisidsv

YS-----QRIGAEEAITKVRDKRPDSIQSRSQIELVVQFSLF
 .     . .   . .|..| |||  .|.. |  ..    | 
vahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 187-276 3.7e-06 21.2 In-house 161-262 (274) alignment 
Range on Protein: 187-276
Range on HMM: 161-262/274.0
QNIYYYNYP-LPDYST-FSVENMLDVVKVIDFSCLN-----GRIAIHCHAGLGRTGSVIACYLVYSQ-----RIGAEEAITKVRDKRPDSIQSRSQIELV
.....| |.  ||  .  .....||.|. .. |  .     . . .|| ||.||||  ||  .   |      .   . ....| .|   .|...| ||.
rsvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyeli

VQ
 .
hr
subfamily_LRR-DSP_pd Subfamily LRR-DSP 214-264 5.1e-06 19.8 In-house 191-241 (263) alignment 
Range on Protein: 214-264
Range on HMM: 191-241/263.0
IDFSCLNGRIAIHCHAGLGRTGSVIACYLVYSQRIGAEEAITKVRDKRPDS
|.    .| . .|| ||. |. ... .||.  ||.  .||.  |  |||  
ieeGrkkGGvlvhcraGvsrsstlvisylmkkqrlkfkealdlvikkrpri
subfamily_Tensin_pd Subfamily Tensin 178-253 5.6e-06 19.0 In-house 59-137 (189) alignment 
Range on Protein: 178-253
Range on HMM: 59-137/189.0
TYKPEDLMRQNIYYYNYPLPDYSTFSVENMLDVVKVIDF---SCLNGRIAIHCHAGLGRTGSVIACYLVYSQRIGAEEA
. |  |. . |    ..  ||  . |.| .  ..| .|    . ..  ...||. | ||.| |...|. ||.   ...|
sekrydisklnkkvldfGWPdllaPsleklcsicksldsWlkadpqnvvvvhckGgkgrigvvvsaymkyskisasada
subfamily_PTPRB_pd Subfamily PTPRB 194-270 5.9e-06 20.5 In-house 192-273 (293) alignment 
Range on Protein: 194-270
Range on HMM: 192-273/293.0
YPLPDYSTFSVENMLDVVKVIDFSCLNGRIAIHCHAGLGRTGSVIACYLVYS-----QRIGAEEAITKVRDKRPDSIQSRSQ
.  |. ..  .. .  | ..|. .. .. | .|| ||.||||  ||   . .     . .     ....| .|   .|. .|
hgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekq
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 184-267 6.2e-06 19.8 In-house 48-132 (148) alignment 
Range on Protein: 184-267
Range on HMM: 48-132/148.0
LMRQNIYYYNYPLPDYSTFSVENML-DVVKVIDFSCLNG-RIAIHCHAGLGRTGSVIACYLVYSQRIGAEEAITKVRDKRPDsIQS
|  . | |.. .| |   . .  .  |... ..    .| |. .|.. |  |   .   .|.  .|.  .||.  |..||.  .. 
ldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkrvslkealalvkskrry.vdp
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 190-263 6.5e-06 19.6 In-house 57-134 (154) alignment 
Range on Protein: 190-263
Range on HMM: 57-134/154.0
YYYNYPLPDYSTFSVENMLDV-VKVIDFSC---LNGRIAIHCHAGLGRTGSVIACYLVYSQRIGAEEAITKVRDKRPD
 | |  | |   | . . ||   . || .     |... .|...|. |. ...  ||. ...|   .|.  ..| |. 
eylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaallisylmdklkislslalellkdsryi
subfamily_DSP14_pd Subfamily DSP14 201-262 6.5e-06 20.2 In-house 62-125 (157) alignment 
Range on Protein: 201-262
Range on HMM: 62-125/157.0
TFSVENMLDVV--KVIDFSCLNGRIAIHCHAGLGRTGSVIACYLVYSQRIGAEEAITKVRDKRP
. .. . .| |  |. . .  .|.. .|| ||  |  |.   ||.  ...  .|| . |...||
eaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylmkyeklsLreayklvksaRp
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 203-277 6.8e-06 20.3 In-house 193-274 (288) alignment 
Range on Protein: 203-277
Range on HMM: 193-274/288.0
SVENMLDVVKVIDFSCL--NGRIAIHCHAGLGRTGSVIACYLVY-----SQRIGAEEAITKVRDKRPDSIQSRSQIELVVQF
| ...|.... .. .     |.| .|| ||.||||  ||   .      .. |   ....|.| .|.  .|  .| | . . 
skapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyev