Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
| Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
|---|---|---|---|---|---|---|---|---|---|
| subfamily_MTMR10_pd | Subfamily MTMR10 | 37-155 | 1e-28 | 92.2 | In-house | 174-305 (380) | alignment | ||
Range on Protein: 37-155
Range on HMM: 174-305/380.0
FAFDYARVVHKTKDTHSSSSSSSQDVI------------PTYFNPRDWQKELDRLGVNQKQWRVTEANQHFLLCDSLPPYIVVPYNISDDTLE-YAAGLH
.|.|....|...|.......|...|.. |.|.. ...|..... .|.............. ..|..|.........|..|| ... ..
tasdavktvvekkrsvilqesegrDlscvvaSLaqlmldphyrtisGfqsliqkewvaaghpfldrlghikpseksespvfllFldcvdqlleqfpseFe
FKNRLPVWCWSHSVIGVSLTRGSLPDEDRLEA
|........|..|..|. ||. . .| ||.|
FtetfLialwdsshsgifltflfnseeqrlka
|
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| Myotub-related | Myotubularin-like phosphatase domain | 36-148 | 7.1e-24 | 77.2 | Pfam-A | 2-103 (353) | alignment | ||
Range on Protein: 36-148
Range on HMM: 2-103/353.0
LFAFDYARVVHKTKDTHSSSssssqdviptyfNPRDWQKELDRLGVNQKQ-WRVTEANQHFLLCDSLPPYIVVPYNISDDTLEYAAGLHFKNRLPVWCWS
|.|| | . ..||...| . .|..||. |||..... ||....|... ||.| | ...|| .|||..|. .| |.||||...
lyafsykakkselkdkkdsl............kiedlekeykrlglssskawriskvNenYelcesYPaklivPksisdeelkkvakfrskkRlPvlsyr
HSVIGVSLTRGSLP
| |..|.| | |
hkengavlvRssqp
|
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| Myotub-related | Myotubularin-like phosphatase domain | 36-148 | 7.1e-24 | 77.2 | In-house | 2-103 (353) | alignment | ||
Range on Protein: 36-148
Range on HMM: 2-103/353.0
LFAFDYARVVHKTKDTHSSSssssqdviptyfNPRDWQKELDRLGVNQKQ-WRVTEANQHFLLCDSLPPYIVVPYNISDDTLEYAAGLHFKNRLPVWCWS
|.|| | . ..||...| . .|..||. |||..... ||....|... ||.| | ...|| .|||..|. .| |.||||...
lyafsykakkselkdkkdsl............kiedlekeykrlglssskawriskvNenYelcesYPaklivPksisdeelkkvakfrskkRlPvlsyr
HSVIGVSLTRGSLP
| |..|.| | |
hkengavlvRssqp
|
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| 0040695 | (Phosphotyrosine protein) phosphatases II | 65-148 | 2.8e-22 | 73.0 | In-house | 6-89 (388) | alignment | ||
Range on Protein: 65-148
Range on HMM: 6-89/388.0
TYFNPRDWQKELDRLGVNQKQWRVTEANQHFLLCDSLPPYIVVPYNISDDTLEYAAGLHFKNRLPVWCWSHSVIGVSLTRGSLP
. . .|. .|| |||.. . ||.. |... ||.|.|...|||. |||..|...| |.|.||....|. | .|.| | |
egwslydilrelkrlglgldlwrisivNenyelcpsYPallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqp
|
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| subfamily_Dicty-MTMR1-like_pd | Subfamily Dicty-MTMR1-like | 70-148 | 5e-19 | 60.7 | In-house | 19-98 (404) | alignment | ||
Range on Protein: 70-148
Range on HMM: 19-98/404.0
RDWQKELDRLGVNQK-QWRVTEANQHFLLCDSLPPYIVVPYNISDDTLEYAAGLHFKNRLPVWCWSHSVIGVSLTRGSLP
| ..| |||.... .||....|... ||.. | ..||| .|||. |. .| |.|.|| .| | ....|| | |
ydaeeEykRlgikseseWriskinsdyelcetYPkllvvPesisDeelkkvasfRskgRiPvlswrhrsknstitRssqp
|
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| subfamily_MTMR1_pd | Subfamily MTMR1 | 71-148 | 5.7e-17 | 54.1 | In-house | 11-89 (389) | alignment | ||
Range on Protein: 71-148
Range on HMM: 11-89/389.0
DWQKELDRLGVNQK-QWRVTEANQHFLLCDSLPPYIVVPYNISDDTLEYAAGLHFKNRLPVWCWSHSVIGVSLTRGSLP
| ..||.|||. .. .||.|. |... |||. |. .||| ..||..|. .| .. |.|||| .| . . ...| | |
dpeaelerlgllneklWritklnkkyelcdtYpavlvvpkvvsdedlkkvaafrskgRlPvlswlnkenqavilrasqp
|
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| subfamily_MTMR5_pd | Subfamily MTMR5 | 73-147 | 1.1e-16 | 52.7 | In-house | 11-92 (483) | alignment | ||
Range on Protein: 73-147
Range on HMM: 11-92/483.0
QKELDRLGVN-------QKQWRVTEANQHFLLCDSLPPYIVVPYNISDDTLEYAAGLHFKNRLPVWCWSHSVIGVSLTRGSL
.. .|||.. ....|..|.|... .|.| | |||| ..|||... | . .||||| .| |. . | |..
vqdykRlGlgalngaskrgkfrisevNkkytvcrsYPalivvPsevsddsiarvakcfrqnRlPvvtWrhernkalLiRsgg
|
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| subfamily_MTMR3_pd | Subfamily MTMR3 | 68-149 | 1.3e-16 | 53.4 | In-house | 25-107 (442) | alignment | ||
Range on Protein: 68-149
Range on HMM: 25-107/442.0
NPRDWQKELDRLGVN-QKQWRVTEANQHFLLCDSLPPYIVVPYNISDDTLEYAAGLHFKNRLPVWCWSHSVIGVSLTRGSLPD
. ..|..||| . ...||....|..| || | | ..|| |.||.|. .| .|||. | | | |.| | |.
aeeklkeeverlGfdlkeawrisdvnsdfklCssyPkklivPksitdddlkkvasfrslkrlPavvwrhkkngavlarcsqPe
|
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| subfamily_MTMR9_pd | Subfamily MTMR9 | 65-148 | 2.8e-15 | 48.3 | In-house | 13-96 (393) | alignment | ||
Range on Protein: 65-148
Range on HMM: 13-96/393.0
TYFNPRDWQKELDRLGVNQKQWRVTEANQHFLLCDSLPPYIVVPYNISDDTLEYAAGLHFKNRLPVWCWSHSVIGVSLTRGSLP
. .. | ..|. .| . ...||... |..| .| | |. ..|| .|.|..|. | . |.|| .. |. . | | | |
dgysafdrenefaklisasdewRissvNknfkvcasypesvivPkaiddeelkasaafreggrfPvLsylhketkavllrssqp
|
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| subfamily_MTMR6_pd | Subfamily MTMR6 | 67-148 | 2.6e-12 | 38.7 | In-house | 19-100 (397) | alignment | ||
Range on Protein: 67-148
Range on HMM: 19-100/397.0
FNPRDWQKELDRLGVNQKQWRVTEANQHFLLCDSLPPYIVVPYNISDDTLEYAAGLHFKNRLPVWCWSHSVIGVSLTRGSLP
.. |...|. |.|| ...| .|..|... |||. | ..|| ... ..| .. . |.|||| . | .. | | |
wklldlkaeytrmgvpnekwtltdlnkdyelcdtyprelyvPksatkevlvgsskfrskgrlPvlsylhkeneaaicrcsqp
|
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| subfamily_pats1_pd | Subfamily pats1 | 74-138 | 1.1e-08 | 26.0 | In-house | 13-76 (691) | alignment | ||
Range on Protein: 74-138
Range on HMM: 13-76/691.0
KELDRLGVNQKQ-WRVTEANQHFlLCDSLPPYIVVPYNISDDTLEYAAgLHFKNRLPVWCWSHSVI
.| .||... . |||.| .. |.. |. |.|| .||. | . . . ..|| .||.
iegqrlkldldkdwrvveflsrd.lseiyPkrilvPklvsdellvsyv.rkrsskiPvlswsnqnn
|
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| subfamily_Ank-MTMR1_pd | Subfamily Ank-MTMR1 | 82-148 | 2.3e-07 | 21.9 | In-house | 38-104 (405) | alignment | ||
Range on Protein: 82-148
Range on HMM: 38-104/405.0
NQKQWRVTEANQHFLLCDSLPPYIVVPYNISDDTLEYAAGLHFKNRLPVWCWSHSVIGVSLTRGSLP
.. |.||. |... .| | . .|| . | || .. | |.| | |..| | |
sncywkvtsinkeykmcssyssslvvlskaldkdlekifsfrskgripslswkdpssnasisrcsqp
|
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