Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
| Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
|---|---|---|---|---|---|---|---|---|---|
| 0040695 | (Phosphotyrosine protein) phosphatases II | 572-967 | 5.2e-69 | 226.7 | In-house | 6-387 (388) | alignment | ||
Range on Protein: 572-967
Range on HMM: 6-387/388.0
TYFNPRDWQKELDRLGVNQKQWRVTEANQHFLLCDSLPPYIVVPYNISDDTLEYAAGLHFKNRLPVWCWSHSVTGVSLTRGSLP-----------DEDRL
. . .|. .|| |||.. . ||.. |... ||.|.|...|||. |||..|...| |.|.||....|. .| .|.| | | ||. |
egwslydilrelkrlglgldlwrisivNenyelcpsYPallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplvglllsrsledekll
EAP------------------------------------------------------------------------------------DPRSCLSLASDIV
|| ...|.|| ||
eailkllpnlskllivdlrpklnalanralgggvenedaypnaeliflnipnihvvreslqklldaclnvpdslnllslleesgwldliklilelavliv
KTLCEKRTSCVLLDQNDRDLACVISSLVQIMADPHYRTISGFESLVQKEWVAMGHPFMTRSGLITDAPsneelVPDGQAPVFVLFCDCVWQLTVQFPSAF
| | . .|... . ...|. ...|||.|.. ||.|||. || .|..|||...||.|..|.|. . ... .|||.|| ||||||. |||.||
klldlgnssvlvhcsdgwdrtsqlssLaqllldPyYRTleGFqvLiekeWlsfghkfadRlghlesei.....dskefsPvFllFLdcvwqLlrqfPtaF
QFTPSFLVKFVSLTASSIYSNFVFDSAKARVEASNHSKRSSYyvsqsvdlqgshsdaekyegplvsawgkWRSSLT---AeetenWLNPFYYIFGsgdah
.|.. .|. .. . |.....|.|.| | |.|.| .....| |. | .|||.| .
eFnerlLlfLadhlyscrfgtFlfnsekerlelsvsertlsl............................wsyllsrkse.....flnplYdpss.....
neftftgnllpfessvfnllfsdmlpdktsggnfglysdqplplslssheltperaeqvslhsisssspSPLLLPNTAMPSLVFWVDYFFRFIP
. .|||.. ...|..| .|..|..|
.....................................................................levllpslsvldlllWleyylrwlp
|
|||||||||
| subfamily_MTMR10_pd | Subfamily MTMR10 | 666-967 | 2.8e-62 | 202.7 | In-house | 169-379 (380) | alignment | ||
Range on Protein: 666-967
Range on HMM: 169-379/380.0
RSCLSLASDIVKTLCEKRTSCVLLDQNDRDLACVISSLVQIMADPHYRTISGFESLVQKEWVAMGHPFMTRSGLITDAPSNEElvpdgqaPVFVLFCDCV
| |||.|||.|||..||..|..| ....|||.||..||.|.|.||||||||||.||.||||||.||||..| | |......|. |||.||.|||
rlclstasdavktvvekkrsvilqesegrDlscvvaSLaqlmldphyrtisGfqsliqkewvaaghpfldrlghikpsekses.......pvfllFldcv
WQLTVQFPSAFQFTPSFLVKFVSLTASSIYSNFVFDSAKARVEASNHSKrssyyvsqsvdL----------QGSHSDAEKYEGPLVSawGKWRSSLTAEE
.||. ||||.|.||..||........|.|...|.|.|...|..|...|. . . . | |. .| .. .|
dqlleqfpseFeFtetfLialwdsshsgifltflfnseeqrlkavvsss...........plliakselkendllkdeldyrqglya..eiiksirrlaa
TENWLNPfyyifgsgdahneftftgnllpfessvfnllfsdmlpdktsggnfglysdqplplslssheltperaeqvslhsisssspsPLLLPNTAMPSL
....|. .. | . .| .
aksylrs.................................................................................eiirPllqipdi
VFWVDYFFRFIP
| . ..|..|
qlWdeCYlRWvP
|
|||||||||
| Myotub-related | Myotubularin-like phosphatase domain | 667-808 | 2.4e-42 | 137.9 | Pfam-A | 215-352 (353) | alignment | ||
Range on Protein: 667-808
Range on HMM: 215-352/353.0
SCLSLASDIVKTLCEKRTSCVLLDQNDRDLACVISSLVQIMADPHYRTISGFESLVQKEWVAMGHPFMTRSGLItdapSNEELVPDGQAPVFVLFCDCVW
| |. . .||.. .. .| .. .. .| .....||.|.. ||.||||.||..||.|||...||.| |.| .... . ..|||..|.|||.
slLkasalvvklveseessVlvhcsdGwDrtaqvvslaqllldpyyRtieGfqvLvekeWlsfGhkFaeRvghl....kenkksskesspvFlqFlDcvy
QLTVQFPSAFQFTPSFLVKFVSLTASSIYSNFVFDSAKARVE
||. |||.||.|. ||.|.| . |. . .|...| | | |
qllrqfptaFeFneefLiklvehlyscqfgtFLlnsekeree
|
|||||||||
| Myotub-related | Myotubularin-like phosphatase domain | 667-808 | 2.4e-42 | 137.9 | In-house | 215-352 (353) | alignment | ||
Range on Protein: 667-808
Range on HMM: 215-352/353.0
SCLSLASDIVKTLCEKRTSCVLLDQNDRDLACVISSLVQIMADPHYRTISGFESLVQKEWVAMGHPFMTRSGLItdapSNEELVPDGQAPVFVLFCDCVW
| |. . .||.. .. .| .. .. .| .....||.|.. ||.||||.||..||.|||...||.| |.| .... . ..|||..|.|||.
slLkasalvvklveseessVlvhcsdGwDrtaqvvslaqllldpyyRtieGfqvLvekeWlsfGhkFaeRvghl....kenkksskesspvFlqFlDcvy
QLTVQFPSAFQFTPSFLVKFVSLTASSIYSNFVFDSAKARVE
||. |||.||.|. ||.|.| . |. . .|...| | | |
qllrqfptaFeFneefLiklvehlyscqfgtFLlnsekeree
|
|||||||||
| subfamily_MTMR1_pd | Subfamily MTMR1 | 668-815 | 5.7e-39 | 126.5 | In-house | 197-339 (389) | alignment | ||
Range on Protein: 668-815
Range on HMM: 197-339/389.0
CLSLASDIVKTLCEKRTSCVLLDQNDRDLACVISSLVQIMADPHYRTISGFESLVQKEWVAMGHPFMTRSGLitdapSNEELVPDGQAPVFVLFCDCVWQ
|. | ||... ...|| .. .. | . || ... |..||||.||| |..|||...||.| .| | .... .. ..|||. |.|||||
ilagavkivekvetektsvlvhcsdGWDRtaqltsLamlllDsyyRtieGfevliekeWlsfGHkfkeRlgh.....gdknssdaersPvFlqfiDcvwq
LTVQFPSAFQFTPSFLVKFVSLTASSIYSNFVFDSAKARVEASNHSKR
|| |||.||.|. .||. .. |... .|.|.| |.||... ..|
ltrqfptAFefneefLitlldhlysclfGtflfnsekervkekvkekt
|
|||||||||
| subfamily_Dicty-MTMR1-like_pd | Subfamily Dicty-MTMR1-like | 672-820 | 3e-37 | 120.7 | In-house | 211-353 (404) | alignment | ||
Range on Protein: 672-820
Range on HMM: 211-353/404.0
ASDIVKTLCEKRTSCVLLDQNDRDLACVISSLVQIMADPHYRTISGFESLVQKEWVAMGHPFMTRSGLitdapsNEELVPDGQAPVFVLFCDCVWQLTVQ
. .||... ....|... . | . .|||.|...||.||||.||..|..|||. .|| |..|.| ..| | ..|.|. | |||.||| |
skriveliekekssvlvhcsdgwDrtsqlsslsqllldpyyrtiegFivliekewlsfGhkfaqRigq......ttekssdersPiflqFidcvyqltkq
FPSAFQFTPSFLVKFVSLTASSIYSNFVFDSAKARVEASNHSKRSSYYV
||. |.| .||.| . |. . .|..|| | |... ... | .
fptsFeFnekflikildalyscrfgtFLydsekeRqqnnlaketvslWa
|
|||||||||
| subfamily_MTMR9_pd | Subfamily MTMR9 | 668-819 | 4.6e-37 | 120.0 | In-house | 202-349 (393) | alignment | ||
Range on Protein: 668-819
Range on HMM: 202-349/393.0
CLSLASDIVKTLCEKRTSCVLLDQNDRDLACVISSLVQIMADPHYRTISGFESLVQKEWVAMGHPFMTRSGLITDAPSNEELvpdgQAPVFVLFCDCVWQ
|..| ....| |. .. |. ... | .....||.|.. ||..||. |||.|...||. |||| .| .. .. ...| ..|||.|| |||.|
lleaalvvaqcldeegapvvvhgeeGlDatlqvtsLaqlildpdaRtvrgfealiereWiqaGHPFasRaskvaaketkkkl....sgpvfllFLDcvyq
LTVQFPSAFQFTPSFLVKFVSLTASSIYSNFVFDSAKARVEASNHSKRSSYY
. ||| .| | ..|. . . || ...|. |... | |. ..| | .
ilsqfpasFEFneelLillfehsyssqfgtflcdneaerkelklkkktvslw
|
|||||||||
| subfamily_MTMR5_pd | Subfamily MTMR5 | 670-811 | 3.4e-33 | 107.2 | In-house | 284-419 (483) | alignment | ||
Range on Protein: 670-811
Range on HMM: 284-419/483.0
SLASDIVkTLCEKRTSCVLLDQ-NDRDLACVISSLVQIMADPHYRTISGFESLVQKEWVAMGHPFMTRSGLITDAPSNeelvpdGQAPVFVLFCDCVWQL
|.. .| | . . | ||. . .|. .|||.|.. ||.|||. ||. ||.|||.|.|| | || ... | | | ||||. | |||.|.
qlsgavv.dlldlqgssvlvslEdGwdvtaqvsslaqllldpyYRtleGFkvLveKEWLafGHrFtkrsnqtlsaqss......gfaPvFlqFLDcvhqv
TVQFPSAFQFTPSFLVKFVSLTASSIYSNFVFDSAKARVEASN
. ||| || | .| . | . |..|| . |.|..
srqfPlafefndfylkflayhsvsnrfrtfllDseyerlesgl
|
|||||||||
| subfamily_MTMR3_pd | Subfamily MTMR3 | 672-814 | 4.7e-31 | 101.0 | In-house | 258-395 (442) | alignment | ||
Range on Protein: 672-814
Range on HMM: 258-395/442.0
ASDIVKTLCEKRTsCVLLDQ-NDRDLACVISSLVQIMADPHYRTISGFESLVQKEWVAMGHPFMTRSGLITDAPSNEElvpdgQAPVFVLFCDCVWQLTV
| .|... .. ||. . | . | .| ... ||.|||. ||. ||..||...|| |. |.| . ..| ..|||. . |.| ||.
avkvveavdkegr.pvlvhCsdGWdrttqivalakllldpyyrtleGfkvlvereWldfGhkfadrcghgenvddane.....rcPvflqwldavhqlqr
QFPSAFQFTPSFLVKFVSLTASSIYSNFVFDSAKARVEASNHSK
|||..|.|. .||||.| | |... |...|.|.| | . ...
qfPtsfefneaflvklvqhtysclfGtflansekereeekvker
|
|||||||||
| subfamily_MTMR6_pd | Subfamily MTMR6 | 669-818 | 2.7e-30 | 97.9 | In-house | 209-351 (397) | alignment | ||
Range on Protein: 669-818
Range on HMM: 209-351/397.0
LSLASDIVKTLCEKRTSCVLLDQNDRDLACVISSLVQIMADPHYRTISGFESLVQKEWVAMGHPFMTRSGLITDAPsnEELvpdgqAPVFVLFCDCVWQL
| . | |.. |...|... . | .. . || ... ||.|||| || |..|||...|| | .|.||. ... |. .|.| | .|||||
ldasifiakavaeegasvlvhcsdGwdrtaqvcslasllldpyyrtikGflvliekewlsfGhkfsercGlldeds..kev.....sPiftqflecvwql
TVQFPSAFQFTPSFLVKFVSLTASSIYSNFVFDSAKARVEASNHSKRSSY
. ||| ||.| .||... |. . .|. .. |.| .. . . |
leqfpkafefnerfllelhdhvyscqfGtflgncekdrrdlklkertksl
|
|||||||||
| subfamily_MTMR10_pd | Subfamily MTMR10 | 544-662 | 3.3e-27 | 87.2 | In-house | 174-305 (380) | alignment | ||
Range on Protein: 544-662
Range on HMM: 174-305/380.0
FAFDYARVVHKTKDTHSSSSSSSQDVI------------PTYFNPRDWQKELDRLGVNQKQWRVTEANQHFLLCDSLPPYIVVPYNISDDTLE-YAAGLH
.|.|....|...|.......|...|.. |.|.. ...|..... .|.............. ..|..|.........|..|| ... ..
tasdavktvvekkrsvilqesegrDlscvvaSLaqlmldphyrtisGfqsliqkewvaaghpfldrlghikpseksespvfllFldcvdqlleqfpseFe
FKNRLPVWCWSHSVTGVSLTRGSLPDEDRLEA
|........|..|..|. ||. . .| ||.|
FtetfLialwdsshsgifltflfnseeqrlka
|
|||||||||
| subfamily_Ank-MTMR1_pd | Subfamily Ank-MTMR1 | 684-820 | 1.7e-25 | 81.6 | In-house | 234-363 (405) | alignment | ||
Range on Protein: 684-820
Range on HMM: 234-363/405.0
TSCVLLDQNDRDLACVISSLVQIMADPHYRTISGFESLVQKEWVAMGHPFMTRSGLItdaPSNEElvpdGQAPVFVLFCDCVWQLTVQFPSAFQFTPSFL
| .. . | . |.|| ||. ||.|||| ||. |..|||...|| | | | . | ||| ..|.| | ||..|| ||| |.||||.|
nsilvhcsdgwdrtpqitsltqilldpyyrtivgfqvliekewlsfghkfslrlghl...pgnee....erspifqqfldccfqllsqfpllfeftpsll
VKFVSLTASSIYSNFVFDSAKARVEASNHSKRSSYYV
. | | |. . | ||. . | | .
lfisdnihsckygtflnncekdrvqdqvktktisiws
|
|||||||||
| Myotub-related | Myotubularin-like phosphatase domain | 543-655 | 3.2e-23 | 75.0 | Pfam-A | 2-103 (353) | alignment | ||
Range on Protein: 543-655
Range on HMM: 2-103/353.0
LFAFDYARVVHKTKDTHSSSssssqdviptyfNPRDWQKELDRLGVNQKQ-WRVTEANQHFLLCDSLPPYIVVPYNISDDTLEYAAGLHFKNRLPVWCWS
|.|| | . ..||...| . .|..||. |||..... ||....|... ||.| | ...|| .|||..|. .| |.||||...
lyafsykakkselkdkkdsl............kiedlekeykrlglssskawriskvNenYelcesYPaklivPksisdeelkkvakfrskkRlPvlsyr
HSVTGVSLTRGSLP
| .|..|.| | |
hkengavlvRssqp
|
|||||||||
| Myotub-related | Myotubularin-like phosphatase domain | 543-655 | 3.2e-23 | 75.0 | In-house | 2-103 (353) | alignment | ||
Range on Protein: 543-655
Range on HMM: 2-103/353.0
LFAFDYARVVHKTKDTHSSSssssqdviptyfNPRDWQKELDRLGVNQKQ-WRVTEANQHFLLCDSLPPYIVVPYNISDDTLEYAAGLHFKNRLPVWCWS
|.|| | . ..||...| . .|..||. |||..... ||....|... ||.| | ...|| .|||..|. .| |.||||...
lyafsykakkselkdkkdsl............kiedlekeykrlglssskawriskvNenYelcesYPaklivPksisdeelkkvakfrskkRlPvlsyr
HSVTGVSLTRGSLP
| .|..|.| | |
hkengavlvRssqp
|
|||||||||
| subfamily_Dicty-MTMR1-like_pd | Subfamily Dicty-MTMR1-like | 578-655 | 3.1e-18 | 58.1 | In-house | 20-98 (404) | alignment | ||
Range on Protein: 578-655
Range on HMM: 20-98/404.0
DWQKELDRLGVNQK-QWRVTEANQHFLLCDSLPPYIVVPYNISDDTLEYAAGLHFKNRLPVWCWSHSVTGVSLTRGSLP
| ..| |||.... .||....|... ||.. | ..||| .|||. |. .| |.|.|| .| | .....|| | |
daeeEykRlgikseseWriskinsdyelcetYPkllvvPesisDeelkkvasfRskgRiPvlswrhrsknstitRssqp
|
|||||||||
| subfamily_MTMR1_pd | Subfamily MTMR1 | 578-655 | 2.8e-16 | 51.8 | In-house | 11-89 (389) | alignment | ||
Range on Protein: 578-655
Range on HMM: 11-89/389.0
DWQKELDRLGVNQK-QWRVTEANQHFLLCDSLPPYIVVPYNISDDTLEYAAGLHFKNRLPVWCWSHSVTGVSLTRGSLP
| ..||.|||. .. .||.|. |... |||. |. .||| ..||..|. .| .. |.|||| .| . .. ...| | |
dpeaelerlgllneklWritklnkkyelcdtYpavlvvpkvvsdedlkkvaafrskgRlPvlswlnkenqavilrasqp
|
|||||||||
| subfamily_MTMR5_pd | Subfamily MTMR5 | 581-654 | 3.9e-16 | 50.9 | In-house | 12-92 (483) | alignment | ||
Range on Protein: 581-654
Range on HMM: 12-92/483.0
KELDRLGVN-------QKQWRVTEANQHFLLCDSLPPYIVVPYNISDDTLEYAAGLHFKNRLPVWCWSHSVTGVSLTRGSL
.. .|||.. ....|..|.|... .|.| | |||| ..|||... | . .||||| .| |. .. | |..
qdykRlGlgalngaskrgkfrisevNkkytvcrsYPalivvPsevsddsiarvakcfrqnRlPvvtWrhernkalLiRsgg
|
|||||||||
| subfamily_MTMR3_pd | Subfamily MTMR3 | 576-656 | 1e-15 | 50.5 | In-house | 26-107 (442) | alignment | ||
Range on Protein: 576-656
Range on HMM: 26-107/442.0
PRDWQKELDRLGVN-QKQWRVTEANQHFLLCDSLPPYIVVPYNISDDTLEYAAGLHFKNRLPVWCWSHSVTGVSLTRGSLPD
. ..|..||| . ...||....|..| || | | ..|| |.||.|. .| .|||. | | .| |.| | |.
eeklkeeverlGfdlkeawrisdvnsdfklCssyPkklivPksitdddlkkvasfrslkrlPavvwrhkkngavlarcsqPe
|
|||||||||
| subfamily_MTMR9_pd | Subfamily MTMR9 | 572-655 | 9.4e-15 | 46.6 | In-house | 13-96 (393) | alignment | ||
Range on Protein: 572-655
Range on HMM: 13-96/393.0
TYFNPRDWQKELDRLGVNQKQWRVTEANQHFLLCDSLPPYIVVPYNISDDTLEYAAGLHFKNRLPVWCWSHSVTGVSLTRGSLP
. .. | ..|. .| . ...||... |..| .| | |. ..|| .|.|..|. | . |.|| .. |. |. | | | |
dgysafdrenefaklisasdewRissvNknfkvcasypesvivPkaiddeelkasaafreggrfPvLsylhketkavllrssqp
|
|||||||||
| subfamily_pats1_pd | Subfamily pats1 | 695-736 | 4.4e-12 | 37.2 | In-house | 414-456 (691) | alignment | ||
Range on Protein: 695-736
Range on HMM: 414-456/691.0
DLAC-VISSLVQIMADPHYRTISGFESLVQKEWVAMGHPFMTR
.| |||| |...||.|||. || |..|||. |.|| .
eldlasisslaqvlsdPfyrtldGfkvliekewlsyGfPfski
|
|||||||||
| subfamily_pats1_pd | Subfamily pats1 | 745-819 | 9.3e-12 | 36.1 | In-house | 543-617 (691) | alignment | ||
Range on Protein: 745-819
Range on HMM: 543-617/691.0
SNEELVPDGQAPVFVLFCDCVWQLTVQFPSAFQFTPSFLVKFVSLTASSIYSNFVFDSAKARVEASNHSKRSSYY
. || . .|.|| | | |||| .|| |.| |.|. .| . || . ||... || ..| .. |..
essilvnrsfsPifvqfldlvwqlqkefPfhfefneslllllvkesfssrfGnflyseakrdserkvlkrsksiw
|
|||||||||
| subfamily_MTMR6_pd | Subfamily MTMR6 | 574-655 | 2e-11 | 35.8 | In-house | 19-100 (397) | alignment | ||
Range on Protein: 574-655
Range on HMM: 19-100/397.0
FNPRDWQKELDRLGVNQKQWRVTEANQHFLLCDSLPPYIVVPYNISDDTLEYAAGLHFKNRLPVWCWSHSVTGVSLTRGSLP
.. |...|. |.|| ...| .|..|... |||. | ..|| ... ..| .. . |.|||| . | . .. | | |
wklldlkaeytrmgvpnekwtltdlnkdyelcdtyprelyvPksatkevlvgsskfrskgrlPvlsylhkeneaaicrcsqp
|
|||||||||
| Death | Death domain | 25-99 | 2.6e-08 | 21.6 | Pfam-A | 12-81 (83) | alignment | ||
Range on Protein: 25-99
Range on HMM: 12-81/83.0
TSDWRKFGSVAGLRYNTLNIIQENKTKVEDRFEECLACWLRRedkvdSKGKPSWRRLADILEELGDKALADKIRS
..||..... || ..... |... ...... | | | | . . . ..|...|..|| .|.|..|
gkdWkeLarkLglsedeideiesenprlreqtyelLqlWeqr.....egknatlgaLleaLrklgrrdaaekles
|
|||||||||
| subfamily_pats1_pd | Subfamily pats1 | 581-650 | 1.3e-07 | 22.4 | In-house | 13-81 (691) | alignment | ||
Range on Protein: 581-650
Range on HMM: 13-81/691.0
KELDRLGVNQKQ-WRVTEANQHFlLCDSLPPYIVVPYNISDDTLEYAAgLHFKNRLPVWCWSHSVTGVSLT
.| .||... . |||.| .. |.. |. |.|| .||. | . . . ..|| .||. ||
iegqrlkldldkdwrvveflsrd.lseiyPkrilvPklvsdellvsyv.rkrsskiPvlswsnqnnksslf
|
|||||||||
| DUF3584 | Protein of unknown function (DUF3584) | 981-1102 | 1.6e-06 | 13.0 | Pfam-A | 816-941 (1201) | alignment | ||
Range on Protein: 981-1102
Range on HMM: 816-941/1201.0
QLQSKLVKEVRKLKEALNDLELERGEQTSDFSRFIREIMKARDEE-KRLRKLKRDAS--HEIARRMsAFITMSSEDEDCDRSLDKLNSPVGSVHDKAKTL
. . .| .....|...|..|| |......| . .....|.|. |.| .|. . .. ... |.. .. ..|. . .... .. . . .| | |
eerpalkeqleelessleeleqelarlikdlklerkklekerkalekqldqldeelrklrdelskl.aelkldknaeqaegevserlaaleelkrkrkrl
PAKLDDSLSKFADEL--HNNGEFAKRF
... |..| | |. |.|. .
seavkkalerfkgvlkdhsgselaetw
|
|||||||||
| subfamily_Ank-MTMR1_pd | Subfamily Ank-MTMR1 | 589-655 | 2e-06 | 18.8 | In-house | 38-104 (405) | alignment | ||
Range on Protein: 589-655
Range on HMM: 38-104/405.0
NQKQWRVTEANQHFLLCDSLPPYIVVPYNISDDTLEYAAGLHFKNRLPVWCWSHSVTGVSLTRGSLP
.. |.||. |... .| | . .|| . | || .. | |.| | . |..| | |
sncywkvtsinkeykmcssyssslvvlskaldkdlekifsfrskgripslswkdpssnasisrcsqp
|
|||||||||